Henrietta Lacks' hometown will build statue of her to replace Robert E. Lee monument
A statue of the woman, whose cells were taken without her consent and became integral in several major medical breakthroughs, will be built in Roanoke, Va. (Image credit: Matt Gentry/The Roanoke Times via AP)
A Field at a Crossroads: Genetics and Racial Mythmaking
As their research is twisted to fuel racist claims, many geneticists are weighing the societal risks of their work
Novel spatial-omics technology enables investigation of diseases at their early stages
How can you trace a single diseased cell in an intact brain or a human heart? The search resembles looking for a needle in a haystack. The teams of Ali Ertürk at Helmholtz Munich and LMU Munich and Matthias Mann at the Max Planck Institute of Biochemistry in Martinsried near Munich have now developed a new technology named DISCO-MS that solves the problem. DISCO-MS uses robotics technology to obta
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New immersive story map brings to life world's longest mule deer migration
For the first time, researchers have published a geonarrative revealing the record-breaking journey of Deer 255, whose story illustrates the challenges and opportunities for conserving migratory mule deer herds across the changing American West.
Multidecadal oscillations not to be confused with reduced warming, says study
Over the last century, sea surface temperatures in the North Atlantic have oscillated over periods of a few decades. These oscillations have not been limited to the ocean. Corresponding variations have been observed in the Arctic sea-ice cover, in ocean currents and in the air up to the stratosphere, more than ten kilometers above the ground.
Generating human-like neural networks via cellular reprogramming
A study published in the journal Stem Cells Reports reveals that a cellular reprogramming methodology allows the creation of neural networks that reproduce unique characteristics of human cells—different to those obtained from rodent cells—with temporary dynamics similar to human brain development.
The peculiar history of thornapple, the hallucinogenic weed that ended up in supermarket spinach
The agent that contaminated baby spinach, prompting the recent national recall, has been revealed. It's a weed, not deliberate misadventure or a chemical contaminant.
Police gun violence is glorified on screen, but more armed and aggressive policing doesn't actually make us safer
American popular culture dominates international markets. Among its most enduringly successful products are police dramas and movies. Many of these feature frequent and overwhelmingly positive depictions of police gun violence—a popular example, and a favorite at this time of year, is Die Hard.
Indonesia's 'blue carbon credits' are crucial for global climate mitigation. Here's how to help them flourish
Indonesia's mangroves and seagrass are one of the key to global climate mitigation efforts, as they store around 17% of the world's "blue carbon".
Generating human-like neural networks via cellular reprogramming
A study published in the journal Stem Cells Reports reveals that a cellular reprogramming methodology allows the creation of neural networks that reproduce unique characteristics of human cells—different to those obtained from rodent cells—with temporary dynamics similar to human brain development.
The peculiar history of thornapple, the hallucinogenic weed that ended up in supermarket spinach
The agent that contaminated baby spinach, prompting the recent national recall, has been revealed. It's a weed, not deliberate misadventure or a chemical contaminant.
Nej, Claus Thomsen, min leder var ikke udokumenteret, og det er ikke synd for Kühnau
I en kommentar kritiserede den lægefaglig direktør på Aarhus Universitetshospital for nylig Dagens Medicins dækning af amputationssagen, der startede i Region Midtjylland og senere blev landsdækkende. Den kritik svarer Dagens Medicins chefredaktør på her.
Research linking soot in Antarctic ice exclusively with early Māori fires was flawed—there were other sources elsewhere
When a recent study implicated forest fires set by early Māori in a hemisphere-wide rise in emissions, it ignited controversy.
Viewpoint: To attain global climate and biodiversity goals, we must reclaim nature in our cities
The climate and biodiversity crises we have been experiencing for the past few decades are inseparable. The scientific research presented at the back-to-back international summits on climate and biodiversity held in Sharm El-Sheikh in Egypt and in Montréal, Canada, respectively, has made this abundantly clear.
Should you answer a call to crowdfund our under-resourced teachers?
In an episode of Abbott Elementary, the sitcom about a group of teachers in an under-resourced Philadelphia school, novice teacher Janine takes to TikTok. The joke is that she needs to use TikTok to fundraise to get her classroom much needed school supplies.
How to make the perfect pavlova, according to chemistry experts
The pavlova is a summer icon; just a few simple ingredients can be transformed into a beautifully flavored and textured dessert.
Squirrelpox outbreak detected in north Wales: Without a vaccine, the disease will keep decimating red squirrels
Concerns over the spread of squirrelpox have increased after a sick red squirrel was found in Bangor, Wales, in late November.
Biodiversity treaty: UN deal fails to address the root causes of nature's destruction, say professors
A major biodiversity conference, recently concluded in Montreal, Canada, was billed as the event that will decide the "fate of the entire living world." All well then that the meeting closed with what has been hailed as a "historic" breakthrough: a deal to protect 30% of all land and water on Earth by 2030.
Why are most rocks on Earth much younger than the planet itself?
The rocks on Earth are not all the same age. In fact, most are significantly younger than the planet itself. The oldest sections of the oceanic crust are thought to be 200 million years old—a blink of an eye in the planet's billion-year lifespan. What is going on here?
Finding hidden regularities in nature: Researchers apply deep learning to X-ray diffraction
X-ray diffraction (XRD) is an experimental technique to discern the atomic structure of a material by irradiating it with X-rays at different angles. Essentially, the intensity of the reflected X-rays becomes high at specific irradiation angles, producing a pattern of diffraction peaks. An XRD serves as a fingerprint for a material since each substance produces a unique pattern.
Fe3O4@Glycerol-Cu as a novel heterogeneous magnetic nanocatalyst for the green synthesis of 2-amino-4H-chromenes
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26769-9 Fe 3 O 4 @Glycerol-Cu as a novel heterogeneous magnetic nanocatalyst for the green synthesis of 2-amino-4 H -chromenes
Viewpoint: To attain global climate and biodiversity goals, we must reclaim nature in our cities
The climate and biodiversity crises we have been experiencing for the past few decades are inseparable. The scientific research presented at the back-to-back international summits on climate and biodiversity held in Sharm El-Sheikh in Egypt and in Montréal, Canada, respectively, has made this abundantly clear.
Squirrelpox outbreak detected in north Wales: Without a vaccine, the disease will keep decimating red squirrels
Concerns over the spread of squirrelpox have increased after a sick red squirrel was found in Bangor, Wales, in late November.
Biodiversity treaty: UN deal fails to address the root causes of nature's destruction, say professors
A major biodiversity conference, recently concluded in Montreal, Canada, was billed as the event that will decide the "fate of the entire living world." All well then that the meeting closed with what has been hailed as a "historic" breakthrough: a deal to protect 30% of all land and water on Earth by 2030.
The Year in Comments
Every Quanta article, video and podcast has its own backstory. By the time it arrives on your screen, our staff has nurtured it through weeks (and sometimes months) of careful work: research, reporting, writing, editing, art direction, animation, filming, recording, fact-checking, copy editing and web production. Then it's my turn. My job is to engage with Quanta's audience and facilitate… Sour
How Vera C. Rubin telescope could halve interference from satellites
A telescope at the Vera C. Rubin Observatory could cut satellite interference in its images by half by sacrificing about 10 per cent of the time spent observing the night sky
Polar vortex is set to drive record cold temperatures in the US
An intense winter storm is expected to bring wind chills as low as -70°F (-57°C) to parts of the US
California's carbon offsetting may actually be increasing emissions
The state's ambitious plan to be carbon-neutral by 2045 relies on carbon offsets through the state's forests. But scientists say it may be causing more harm than good
The Child Tax Credit Was a Little Too Subtle
W hy doesn't anyone care about the expanded child tax credit? A $100 billion policy—effective, important, elegantly designed, competently managed, and noncontroversial—is gone, at least for now. And nobody, save for a few politicians and wonks, seems to have noticed or to care. [ Annie Lowrey: Cash for kids comes to the United States ] The expanded child tax credit (CTC) provided no-strings-attac
Novel spatial-omics technology enables investigation of diseases at their early stages
How can you trace a single diseased cell in an intact brain or a human heart? The search resembles looking for a needle in a haystack. The teams of Ali Ertürk at Helmholtz Munich and LMU Munich and Matthias Mann at the Max Planck Institute of Biochemistry in Martinsried near Munich have now developed a new technology named DISCO-MS that solves the problem. DISCO-MS uses robotics technology to obta
Ulrich Fredberg: Karkirurgisagen fra Midtjylland er indiskutabelt en skandale
Den største af de mange skandaler i karkirurgiskandalen i Region Midtjylland er, at den øverste administrative og politiske ledelse var tonedøve og valgte at ignorere alle de mange faglige advarsler, skriver Ulrich Fredberg, overlæge og regionsrådsmedlem for Venstre.
Physical fitness a demographic watershed
Sedentary behavior, a large waist circumference, and advanced age: These factors are clearly associated with inferior physical fitness among people aged 50 to 64. In a study with over 5,000 participants, investigating the correlations in detail, major fitness disparities are shown.
'To save our pets, we need to know our neighbors': Lessons from the Marshall Fire
More than 1,000 pets perished in the Marshall Fire, many of them trapped inside their homes as guardians who had left for the day desperately tried to devise a plan to free them, according to new CU Boulder research.
Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35541-6 The development of 3d-metal-catalyzed β-C–H bond activation via 4-membered metallacycles remains an elusive challenge. Here, the authors report a Ni-Al bimetal-catalyzed β-C(sp3)–H bond activation of formamides via 4-membered nickelacycles.
Ongoing research explores impacts, solutions after Marshall Fire
On Dec. 30, 2021, a quick-moving, grass-fueled wildfire in suburban Boulder County became the costliest wildfire in Colorado history. It burned 6,000 acres, destroyed more than 1,000 homes and damaged thousands of others.
'To save our pets, we need to know our neighbors': Lessons from the Marshall Fire
More than 1,000 pets perished in the Marshall Fire, many of them trapped inside their homes as guardians who had left for the day desperately tried to devise a plan to free them, according to new CU Boulder research.
High-energy X-rays leave a trace of destruction in bone collagen
A team of medical researchers has analyzed damage by focused high energetic X-rays in bone samples from fish and mammals at BESSY II. With a combination of microscopy techniques, the scientists could document the destruction of collagen fibers induced by electrons emitted from the mineral crystals. X-ray methods might impact bone samples when measured for a long time they conclude.
New X-ray imaging technique to study the transient phases of quantum materials
The use of light to produce transient phases in quantum materials is fast becoming a novel way to engineer new properties in them, such as the generation of superconductivity or nanoscale topological defects. However, visualizing the growth of a new phase in a solid is not easy, due in-part to the wide range of spatial and time scales involved in the process.
How the Hera asteroid mission will phone home
This is the antenna that will transmit back the first close-up images of the distant Dimorphos asteroid since its orbit was shifted by a collision with NASA's DART spacecraft.
Rewriting the textbook on gene regulation: It's the big picture that counts
A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation. During transcription, information stored in DNA is copied into messenger RNA (mRNA). Then during translation, the ribosomes assemble proteins one amino acid at a time based on the instruction specified on the mRNA.
Tomb of 'Jesus' midwife' excavated, revealing remarkable courtyard and oil lamps
Archaeologists in Israel have discovered new artifacts and carvings from the Cave of Salome, a place of pilgrimage for early Christians who thought that it was the burial place for Salome, the supposed midwife of Jesus.
Could more acidic air keep viruses from spreading?
Aerosols in indoor air can vary in acidity, and the acidity determines how long viruses remain infectious in the air, research finds. Viruses such as SARS-CoV-2, influenza, and others travel from person to person by "hitchhiking" on aerosols. An infected person expels the finely dispersed particles when they cough, sneeze, or just exhale. Someone else can then inhale them. It's not clear how long
1 thing can help holiday parties boost well-being
Making an intentional effort to recognize positive life events and achievements while gathering for food and drink at holiday parties will leave you and others feeling more socially supported, according to new research The study finds that celebrations with three conditions—social gathering, eating or drinking, and intentionally marking a positive life event—will increase perceived social support
Probe could find whether Saturn's moon hosts life
The mystery of whether microbial alien life might inhabit Enceladus, one of Saturn's 83 moons, could be solved by an orbiting space probe, according to a new study. In a new paper in the Planetary Science Journal , the researchers map out how a hypothetical space mission could provide definite answers. When Enceladus was initially surveyed in 1980 by NASA's Voyager 1 spacecraft, it looked like a
Experimental study of an asymmetric valveless pump to elucidate insights into strategies for pediatric extravascular flow augmentation
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26524-0
Rewriting the textbook on gene regulation: It's the big picture that counts
A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation. During transcription, information stored in DNA is copied into messenger RNA (mRNA). Then during translation, the ribosomes assemble proteins one amino acid at a time based on the instruction specified on the mRNA.
Africa's path to clean mobility — driven by motorcycles | Adetayo Bamiduro
A lack of infrastructure in parts of Africa has made unregulated, gas-powered motorcycle taxis widespread — a system that gets people where they need to be, but heavily pollutes the air and excludes drivers from the formal economy. TED Fellow and entrepreneur Adetayo Bamiduro offers his vision for a cleaner, more equitable future, where an electric motorcycle service helps green Africa's transpor
Energy crisis: The five challenges for 2023
How will the map of global energy change? Will sky-high energy prices boost renewables? How will the industrial landscape shift? What will the lasting economic impacts be? How will the energy crisis affect climate action? These are the five crucial questions that researchers around the world will be asked to focus on in 2023. It will be up to them to find adequate answers to support government act
Mosquitoes highly resistant to insecticides found in Vietnam and Cambodia
A team of researchers affiliated with multiple institutions in Japan, working with colleagues from Vietnam, Cambodia, Singapore, Taiwan, Indonesia and Ghana, has found evidence of mosquitoes that are highly resistant to common insecticides in both Vietnam and Cambodia.
Fewer infectious particles from children's lungs
Children exhale significantly fewer potentially infectious particles than adults — at least this is true for the small respiratory droplets that are predominantly produced in the lungs.
High-energy X-rays leave a trace of destruction in bone collagen
A team of medical researchers has analyzed damage by focused high energetic X-rays in bone samples from fish and mammals at BESSY II. With a combination of microscopy techniques, the scientists could document the destruction of collagen fibers induced by electrons emitted from the mineral crystals. X-ray methods might impact bone samples when measured for a long time they conclude.
Head trauma, PTSD may increase genetic variant's impact on Alzheimer's risk
Researchers concluded that PTSD, TBI, and a specific variant of the APOE gene showed strong associations with Alzheimer's Disease and related dementias (ADRD).
New cause of melting Antarctic ice shelves
Researchers have discovered a process that can contribute to the melting of ice shelves in the Antarctic. An international team of scientists found that adjacent ice shelves play a role in causing instability in others downstream. The study also identified that a small ocean gyre — a system of circulating ocean currents — next to the Thwaites Ice Shelf can impact the amount of glacial-meltwater
Cre AI tives – The largest database for AI related resources with over 1,200 resources and updated daily.
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The Year in Math
We can think of a mathematician as a kind of archaeologist, painstakingly brushing dust off the hidden structures of the world. But the structures mathematicians reveal are not only durable, but also inevitable. They could never have been any other way. They are also remarkably interconnected: Though each year the mathematical frontier continues to expand as new discoveries are made… Source
Mosquitoes highly resistant to insecticides found in Vietnam and Cambodia
A team of researchers affiliated with multiple institutions in Japan, working with colleagues from Vietnam, Cambodia, Singapore, Taiwan, Indonesia and Ghana, has found evidence of mosquitoes that are highly resistant to common insecticides in both Vietnam and Cambodia.
Auxin and jasmonic acid function synergistically during seed germination
Flowering plants proliferate through sexual reproduction and seed production. Seed germination and subsequent post-germinative growth are strictly regulated and require the precise coordination of multiple environmental and internal cues, including phytohormones. Abscisic acid (ABA) represses seed germination and post-germinative growth in Arabidopsis thaliana. Auxin and jasmonic acid (JA) stimula
Lost fish find their way, thanks to their 'ancient brain'
A zebrafish swims toward its intended target, but strong currents push it off course. Nevertheless, the tiny fish swims back to its original location, determined to finish its journey.
Findings refute '13 Reasons Why' suicide effect
Seasonal changes and other factors eliminate the apparent suicide contagion effect reported from the release of the first season of 13 Reasons Why, a study finds. The seasonal pattern of adolescent suicide also appears to follow the school year, with a decline in the summer months when youths are not in school—an association that has not received much attention in scholarly literature. The first
California earthquake puts early warning system to the test
As sensors picked up the first signs of a strong earthquake jolting the Northern California coast, an alert was blasted to 3 million smartphone users telling them to "drop, cover, hold on." It was hailed as the biggest test yet of the warning system since its public launch.
New tectonic plate model could improve earthquake risk assessment
New Zealand is no stranger to earthquakes. Scientists estimate that more than 20,000 occur each year, and the deadliest ones can shudder the entire nation.
Researchers discuss recent quantum computer wormhole model
Quantum Wormhole
A recent Nature publication continues to generate headlines over its findings that scientists from the California Institute of Technology developed a model of a traversable wormhole on the Google Sycamore quantum processing system.
Exploring formation of oligomers from reactions of hydroperoxide esters with Criegee intermediates
Hydroperoxide esters, formed in the reactions of carbonyl oxides (also called Criegee intermediates, CIs) with formic acid, play a crucial role in the formation of secondary organic aerosol (SOA) in the atmosphere.
Auxin and jasmonic acid function synergistically during seed germination
Flowering plants proliferate through sexual reproduction and seed production. Seed germination and subsequent post-germinative growth are strictly regulated and require the precise coordination of multiple environmental and internal cues, including phytohormones. Abscisic acid (ABA) represses seed germination and post-germinative growth in Arabidopsis thaliana. Auxin and jasmonic acid (JA) stimula
Meta-optics: The disruptive technology you didn't see coming
Robots and autonomous cars will have eyes that see much more than the human eye is capable of, a review of the growing field of meta-optics has found.
Experimentalists: Sorry, no oxygen required to make these minerals on Mars
When NASA's Mars rovers found manganese oxides in rocks in the Gale and Endeavor craters on Mars in 2014, the discovery sparked some scientists to suggest that the red planet might have once had more oxygen in its atmosphere billions of years ago.
Hunter-gatherer social ties spread pottery-making far and wide
Analysis of more than 1,200 vessels from hunter-gatherer sites has shown that pottery-making techniques spread vast distances over a short period of time through the transmission of social traditions.
Lost fish find their way, thanks to their 'ancient brain'
A zebrafish swims toward its intended target, but strong currents push it off course. Nevertheless, the tiny fish swims back to its original location, determined to finish its journey.
Rwandan tree carbon stock mapped from above
Researchers at University of Copenhagen have developed a method to map the carbon stock of individual trees by collaborating with Rwandan authorities and researchers. Together they have created a national inventory of tree-level carbon stocks in Rwanda.
Overshooting climate targets could significantly increase risk for tipping cascades
Temporarily overshooting the climate targets of 1.5–2 degrees Celsius could increase the tipping risk of several Earth system elements by more than 70% compared to keeping global warming in line with the United Nations Paris Agreement range, a new risk analysis study by an international team of researchers shows. This tipping risk increases even if in the longer term the global temperature would s
Huge 2,000-year-old Mayan civilization discovered in northern Guatemala
A team of researchers affiliated with multiple institutions in the U.S., working with a colleague from France and another from Guatemala, has discovered a very large 2,000-year-old Mayan civilization in northern Guatemala. In their paper published in the journal Ancient Mesoamerica, the group describes using LiDAR to conduct a survey of the area.
Can dogs smell time? Just ask Donut the dog
After decades of wondering, an NPR reporter finally figures out how her husband's family dog knew when the school bus would arrive everyday. She did some digging — and now it all makes scents. (Image credit: Lauren Gao for NPR)
Fatal Attraction: What is Sex and Love Addiction?
Have you ever been in love? Has it made you do crazy things? Whether it was sending your lover bundles of flowers, stalking their social media (or stalking them in person), or boiling a rabbit in a pot of water, we've all been there. We know that love is enthralling. It is potent enough in […]
Clay hydroxyl isotopes show an enhanced hydrologic cycle during the Paleocene-Eocene Thermal Maximum
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35545-2 Novel measurements of clay hydroxyl isotopic composition show an enhanced hydrological cycle during a period of intense global warming at the Paleocene-Eocene boundary 55.9 million years ago.
Slight compositional variation-induced structural disorder-to-order transition enables fast Na+ storage in layered transition metal oxides
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35597-4 In layered transition metal oxides as cathode active materials for Na-ion batteries, Na+ diffusion kinetics are impacted by Na+/vacancy ordering. Here, the authors suggest that the P2-type Na2/3Ni1/3Mn2/3O2 with large zigzag ordering exhibits high Na+ mobility and thus superior rate capability.
Automated simulation software creates a world map of polymer properties
A research team has published their method to create a comprehensive database of polymer properties, as well as experimental validation, in npj Computational Materials.
The Year in Physics
The year began right as the James Webb Space Telescope was unfurling its sunshield — the giant, nail-bitingly thin and delicate blanket that, once open, would plunge the observatory into frigid shade and open up its view of the infrared universe. Within hours of the ball dropping here in New York City, the sunshield could have caught on a snag, ruining the new telescope and tossing billions of…
A $3.5 Billion EV Battery Plant Will Be Built in South Carolina Next Year
Redwood South Carolina
As the world attempts to transition away from fossil fuels over the next several decades, critical minerals will likely be among the world's most sought-after commodities. The US isn't in a great position with respect to resources like cobalt, lithium, or graphite, all of which are needed for electric vehicles. China, meanwhile, controls 65 percent of the supply chains for battery-ready lithium c
Fossils give clues as to how turtles might respond to a warming planet
The distribution of ancient turtles from when the planet was warmer than today is helping scientists to anticipate how living turtles may respond to environmental change.
Photonic chip with record-breaking radio frequency dynamic range
Researchers at the University of Twente have developed a revolutionary programmable integrated microwave photonic filter with a record-breaking dynamic range. This represents a major breakthrough in the integration of functionality and performance in radio frequency photonic signal processors.
Study identifies new cause of melting Antarctic ice shelves
Researchers have discovered a process that can contribute to the melting of ice shelves in the Antarctic.
Fossils give clues as to how turtles might respond to a warming planet
The distribution of ancient turtles from when the planet was warmer than today is helping scientists to anticipate how living turtles may respond to environmental change.
Best Thermal Cameras for Phones (2022): Flir, Seek Thermal, Uni-T, Perfect Prime
These infrared imaging devices will show you how hot or cold the objects in the photo are.
Attila the Hun raided Rome due to starvation, not bloodlust, study suggests
The infamous barbarian's most devastating incursions took place in years with extremely dry summers.
Our Favorite Genetics Stories of 2022
This year's stories highlight the expanding versatility of genetic techniques and the increasing utility of such research in all life science fields.
Solutions for Optimizing Stem Cell Therapy Development
Discover how process knowledge is integral to stem cell workflow improvement and optimization.
Brain boost gets rats adjusted to hearing implants faster
Kickstarting the brain's natural ability to adjust to new circumstances, known as neuroplasticity, improves how effectively a cochlear implant can restore hearing loss, a new study in deaf rats shows. The researchers say the investigation may help explain why some implant recipients respond so much better to treatment than others. Unlike hearing aids, which amplify, balance, and sharpen incoming
How to Construct Buildings That Have a Positive Impact on Climate and Biodiversity
BetaPort Denmark
Making buildings part of a circular economy that minimizes the waste of materials could yield huge environmental rewards
Musk's Twitter Drama Isn't Over
Elon Musk now claims that he will step down as Twitter's CEO, contingent on him finding the right replacement. In just eight weeks, Musk has laid off large chunks of the workforce, asked those who remained to commit to being "extremely hardcore," unbanned previously suspended accounts, caused advertisers to flee the platform, kicked a number of journalists off the platform and then reinstated the
Helt ny type hybridtog i Europa: Kører på strøm, batteri og diesel
Den Italienske togoperatør Trenitalia og den japanske togproducent Hitachi Rail er klar med Europas første tri-mode tog, der kan skifte mellem at køre via køreledning, batteri eller diesel.
Ultrafast and ultra-sensitive protein detection method allows for early disease diagnoses
Protein detection based on antigen–antibody reactions is vital in early diagnosis of a wide range of diseases. How to effectively detect proteins, however, has frequently bedeviled researchers. Osaka Metropolitan University scientists have discovered a new principle underlying light-induced acceleration of the antigen–antibody reaction, allowing for simple, ultrafast, and highly sensitive detectio
Collective circular dichroism by chiral plasmonic nanoparticles
Molecular chirality refers to the geometrical property of molecules with broken mirror symmetry. Characterizing molecular chirality and understanding their roles in physiochemical situations has been important in broad research scope such as, biology, chemistry, and pharmaceutics.
Direct observation of the electron and positron capture process
Positrons are anti-particles of electrons. At SuperKEKB B-Factory (SuperKEKB), they are produced in copious amounts and smashed into electrons at world-record luminosity. By studying the hundreds of decay patterns of B mesons and anti B mesons in these collisions, physicists investigate the secrets of matter and antimatter imbalance and traces of other exotic particles beyond the standard model. T
Ultrafast and ultra-sensitive protein detection method allows for early disease diagnoses
Protein detection based on antigen–antibody reactions is vital in early diagnosis of a wide range of diseases. How to effectively detect proteins, however, has frequently bedeviled researchers. Osaka Metropolitan University scientists have discovered a new principle underlying light-induced acceleration of the antigen–antibody reaction, allowing for simple, ultrafast, and highly sensitive detectio
Intracellular phase separation of globular proteins facilitated by short cationic peptides
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35529-2 Phase separation provides intracellular organisation via membraneless entities called biomolecular condensates. Here, the authors show that short, cationic peptide tags can drive biomolecular condensation of engineered proteins in E. coli through associative interactions with RNA.
The Brutal Alternate World in Which the U.S. Abandoned Ukraine
On the shortest day of the year, after 10 months of war, the Ukrainian president, Volodymyr Zelensky, finally left his country and came to Washington to thank Americans for their support. He went to the White House, where he appeared at a press conference. He went to Congress, where he handed a Ukrainian flag, signed by the defenders of Bakhmut, to the vice president and House speaker. He congrat
Male gender bias deters men from some career paths
Men are less likely to seek careers in early education and some other fields traditionally associated with women because of male gender bias in those fields, according to research published by the American Psychological Association.
AT2021fxu is a changing-look active galactic nucleus, observations find
By analyzing the data from NASA's Swift spacecraft and from the Neutron Star Interior Composition Explorer (NICER) onboard the International Space Station, astronomers have investigated an active optical transient known as AT2021fxu. Results of the study, published December 14 on the arXiv preprint server, deliver important insights into the nature of this transient, revealing that it is a changin
Kroppens egna budbärare kan förbättra cancerbehandling
Kroppen har ett system att utbyta information, celler emellan. Forskare tror sig nu ha nu hittat nya sätt att dra nytta av det systemet för att få bättre cancerbehandlingar. Inlägget dök först upp på forskning.se .
Textbooks are failing to cover climate change
College biology textbooks have done a poor job of incorporating material related to climate change, research finds. For example, the study found that most textbooks published in the 2010s included less information about climate change than they did in the previous decade—despite significant advances in our understanding of how climate change is influencing ecosystems and the environment. "In shor
Black patients have less access to safer heart surgeries
Black patients do not have the same level of access to new, safer heart surgery procedures as white patients, a new study suggests. Traditional heart surgery, which involves fully opening the chest and cutting through the breastbone, comes with a high risk of complications and a long recovery time. Newer minimally invasive procedures avoid a lot of that risk and can get people back on their feet
Does xenon gas improve athletic performance?
Were the Russians on to something in 2014 by huffing xenon gas? The post first appeared on Science-Based Medicine .
The New Era of Biofuels Raises Environmental Concerns
To realize the potential of biofuels, the industry needs to pay attention to how feedstock crops change soil carbon
Should we tax robots? – Study suggests a robot levy — but only a modest one — could help combat the effects of automation on income inequality in the U.S.
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Two Earth-mass exoplanets orbiting nearby star discovered
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Money Will Kill ChatGPT's Magic: "Bluntly put, we are going to inhabit the future that offers the most significant returns to investors."
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Genome Spotlight: Fishing cat (Prionailurus viverrinus)
A high-quality reference genome for this vulnerable feline may help scientists understand why they're so prone to transitional cell carcinoma in captivity.
Therabody Smart Goggles Review: Heat, Vibrations, and Massage
This wearable heats up, vibrates, and soothes sore eyes and temples. I don't want to take it off.
Nu har 11 ud af 12 partier sat navn på deres sundhedsordfører
Venstre er det seneste parti i rækken til at konstituere sig. Det betyder, at Dansk Folkeparti nu er det eneste parti i Folketinget, der mangler at finde sin kommende sundhedsordfører.
Teen nicotine vaping is 'on its way to becoming endemic'
Nicotine vaping is one of the most common types of substance use for teenagers in 2022, according to results of a new national study. Among 8th grade students, 7% vaped nicotine in the past 30 days in 2022, compared to 6% who used alcohol, and 5% who used cannabis. Among 10th graders, 14% vaped nicotine in the past 30 days, compared to 13.6% and 12% for alcohol and cannabis use, respectively. Amo
Oprydning i virus-navne: SSI vil gruppere corona-varianter på en ny måde
PLUS. Måske slut med BA.5 og BQ.1.1, for suppen af corona-varianter er blevet så stor, at SSI vil supplere overvågningen af virus-stamtræet med en ny opdeling.
Overturning Roe and Other Important Reproductive Health Stories of 2022
As the Supreme Court's Roe v. Wade reversal put reproduction into the political limelight, Scientific American explored a range of issues related to abortion and reproductive health
The Download: space exploration, and why we're hooked on hybrid cars
This is today's edition of The Download , our weekday newsletter that provides a daily dose of what's going on in the world of technology. What's next in space in 2023 We're going back to the moon—again—in 2023. Multiple uncrewed landings are planned for the next 12 months, spurred on by a renewed effort in the US to return humans to the lunar surface later this decade. Both private space compani
The Etymology of Unobtanium
The much-mocked wonder-rock from the 2009 blockbuster 'Avatar' doesn't have an atomic number, but engineers have used the actual word for decades
Overturning Roe and Other Important Reproductive Health Stories of 2022
As the Supreme Court's Roe v. Wade reversal put reproduction into the political limelight, Scientific American explored a range of issues related to abortion and reproductive health
To track drug resistance, test wastewater over 24 hours
A new study shows that composite samples taken over 24 hours at an urban wastewater plant give a much more accurate representation of the level of antibiotic-resistant genes (ARGs) in the water. According to the Centers for Disease Control and Prevention (CDC), antibiotic resistance is a global health threat responsible for millions of deaths worldwide. In the process, the researchers discovered
Can Misinformation Cause Cancer?
What are the known factors that increase the risk of getting cancer? Most people know about smoking, but can probably only guess at other factors, and are likely to endorse things that do not contribute to cancer risk. The known contributors to cancer risk include: smoking, consuming alcohol, low levels of physical activity, getting sunburnt as a child, family history of cancer, HPV infection, an
The Bittersweet Defeat of Mpox
The epidemic has largely subsided, but largely because queer men seem to have learned more from AIDS and Covid-19 than the authorities did.
Male and Female Stem Cells Derived from One Donor in Scientific First
Male Female Cells One
Studying otherwise identical XY, XX, X0, and XXY pluripotent stem cells will allow researchers to investigate sex-based differences in greater depth.
Umami gives plant-based menu a Christmas taste
Boosting the umami is key to pulling off a delicious and plant-based Christmas dinner, says a food engineer. Food scientist Charlotte Vinther Schmidt , postdoctoral researcher at the University of Copenhagen in the food science department, focuses on exploiting the umami taste potential of sustainable foods. Schmidt says it's key for dishes to have enough of the fifth basic taste: umami. Umami is
Compressed ultrahigh-speed single-pixel imaging by swept aggregate patterns
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35585-8 The authors present single-pixel imaging accelerated via swept aggregate patterns (SPI-ASAP), which combines a digital micromirror device with laser scanning for fast and reconfigurable pattern projection, and a lightweight reconstruction algorithm. They demonstrate real-time video streaming at 100 fps, and
Benchmarking tools for detecting longitudinal differential expression in proteomics data allows establishing a robust reproducibility optimization regression approach
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35564-z Longitudinal proteomics holds great promise for biomarker discovery, but the data interpretation has remained a challenge. Here, the authors evaluate several tools to detect longitudinal differential expression in proteomics data and introduce RolDE, a robust reproducibility optimization approach.
Dansk forskning går imod 30 år gammelt paradigme: Skove betyder meget lidt for klimaet
PLUS. CO2-indholdet i atmosfæren lå ikke meget højere, før verdens første skove voksede på Jorden, end det gør i dag. Det viser ny forskning fra Københavns Universitet.
No evidence for an association between alcohol consumption and Multiple Sclerosis risk: a UK Biobank study
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26409-2
Why EVs won't replace hybrid cars anytime soon
Toyota Electric Car
The end could be coming soon for cars as we know them. To limit global warming to 1.5 °C, the 2015 international Paris climate agreement set 2050 as a worldwide deadline to reach net-zero greenhouse-gas emissions. That means gas-powered vehicles will need to be largely off the road by then. And since cars typically have a lifetime of 15 to 20 years, reaching net zero in 2050 would likely mean no
A sneak peek at the biggest science news stories of 2023
What are you looking forward to reading about in 2023? Whether it is health, physics, technology or environment news, New Scientist will have you covered
Massive measles outbreak threatens India's goal to eliminate disease by 2023
Nature, Published online: 22 December 2022; doi:10.1038/d41586-022-04480-z Many children missed routine vaccinations during the COVID-19 pandemic and pockets of the country are still struggling to boost immunization rates.
Pigeon Neurons Use Much Less Energy Than Those of Mammals
Weirdly efficient neurons power birds' dense brains
The Year the NFT Died and Came Back to Life
Rarible The NFT 2022 Year
The market for non-fungible tokens took a nosedive this year. Now, die-hard evangelists think the key to success is finding different ways to use them.
Here Comes a Bomb Cyclone to Ruin Christmas
Winter Bomb Cyclone
The storm's scale and severity is unprecedented. Almost everyone in America, and a fair few in Canada, will feel its force.
Elevator-Pitch Horror Is Here to Stay
Unlike the elevated horror of years past, this new(ish) genre finds a catchy, goofy premise and sticks to it.
Stop Listening to Sleep Experts
There are no rules for achieving perfect slumber. In 2023, people should start paying attention to their own bodies.
To Rebuild Cities After War, Look to the Past
Post-conflict reconstruction projects should be focused on preserving heritage and restoring identity.
The Four-Day Work-Week Is (Almost) Here
The three-day weekend may soon be a reality—but only if policymakers can think of proper countermeasures against voltage drops.
Vertical Farming Has Found Its Fatal Flaw
Europe's energy crisis is forcing companies to switch strategies or close down. The industry's future hangs in the balance.
What Is Flipper Zero? The Hacker Tool Going Viral on TikTok, Explained
Don't be fooled by its fun name and Tamagotchi-like interface—this do-everything gadget is trouble waiting to happen and a whole lot more.
'Mind-boggling' alloy is Earth's toughest material, even at extreme temperatures
A metallic alloy of chromium, cobalt, and nickel is over 100 times tougher than graphene and gets even more resistant to damage at extremely low temperatures.
How to Make the Most of Bad Gifts
" How to Build a Life " is a column by Arthur Brooks, tackling questions of meaning and happiness. Click here to listen to his podcast series on all things happiness, How to Build a Happy Life . A round the holidays, you can bet on seeing a car commercial in which a self-assured-looking husband takes his blindfolded wife out to the driveway, where she finds a brand-new luxury car with a massive b
Asus Breaks World Record by Overclocking Core i9-13900K to 9GHz
ASUS Intel Core 9GHz
Before Intel's new Raptor Lake chips launched, we were impressed that someone could get a Core i9-13900K up to 6.2GHz with a liquid chiller. Now that level of performance has been shattered by the overclocking team at Asus. The team has successfully taken a 13900K over 9GHz, breaking the world record for CPU clock speeds. This is the first time a CPU has been able to break the 9GHz barrier. The s
Pigeon Neurons Use Much Less Energy Than Those of Mammals
Weirdly efficient neurons power birds' dense brains
More than 150 'made-from-scratch' genes are in the human genome. 2 are totally unique to us.
Scientists pinpointed several "made-from-scratch" genes that humans developed after splitting off from chimps.
Author Correction: Application of 5-aminolevulinic acid-mediated Waterlase-assisted photodynamic therapy in the treatment of oral leukoplakia
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26542-y
The US Postal Service is finally getting EVs
USPS US Electric 2028
This article is from The Spark, MIT Technology Review's weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here. The US Postal Service is finally going electric. The USPS announced Tuesday that it plans to acquire at least 66,000 electric delivery vehicles between now and 2028, and all purchases after 2026 will be EVs. In total, the agency will invest nearly $10 billi
The Secret Life of Plant Killers
To take out invasives, the US relies on crews wielding hatchets, chainsaws, and herbicide. It's a messy, fun job—but it may not be enough to stop the spread.
Retraction Watch grows again, thanks to a $250,000 grant from the WoodNext Foundation
Dear Retraction Watch readers, we have some exciting news to share. The WoodNext Foundation has awarded The Center For Scientific Integrity, our parent 501(c)3 nonprofit, a two-year $250,000 grant that will allow us to add another editor. The WoodNext Foundation is the philanthropy of tech innovator and Roku CEO/founder Anthony Wood and his wife Susan, and its mission is "to advance human progres
SYNSPUNKT Ny chatbot er et kæmpe fremskridt inden for sprogteknologi
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Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35539-0
Reply to: A balanced measure shows superior performance of pseudobulk methods in single-cell RNA-sequencing analysis
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35520-x
A balanced measure shows superior performance of pseudobulk methods in single-cell RNA-sequencing analysis
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35519-4
Electrically conductive hybrid organic crystals as flexible optical waveguides
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35432-w The poor conductivity of organic crystals hinders their potential on applications in flexible electronics, wearable devices, and soft robotics. Here, Naumov et al. develop a hybrid organic crystal that shows enhanced electrical conductivity and fast mechanical deformation due to temperature change.
Astrocytes amplify neurovascular coupling to sustained activation of neocortex in awake mice
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35383-2 Neuronal activity increases local cerebral blood flow (CBF) to satisfy metabolic demand, yet the role of astrocytes in this phenomenon is controversial. Here, the authors show that astrocytes amplify CBF only when neuronal activity is sustained.
Atomic design of dual-metal hetero-single-atoms for high-efficiency synthesis of natural flavones
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35598-3 The preparation of single-atom catalysts still suffers from metal aggregation and pore collapsing during pyrolysis. Here the authors report a versatile medium-induced infiltration deposition strategy for the fabrication of a series of single-atom and hetero-single-atom catalysts.
Protective gold idols and 'rejuvenating' amulets found in ancient Egyptian burials
Archaeologists in Egypt have discovered about 20 ancient burials, some of which contain gold idols fashioned to look like the deities Isis, Bastet and Horus.
Nedtur for europæisk rumfart: Vega-raket fejler på sin 'kun' anden opsendelse
Vikaren for de russiske Soyuz-raketter nåede ikke i kredsløb inden den fejlede og førte til tabet af to satellitter.
What's next in space in 2023
We're going back to the moon—again—in 2023. Multiple uncrewed landings are planned for the next 12 months, spurred on by a renewed effort in the US to return humans to the lunar surface later this decade. Both private space companies and national agencies are set to make the 240,000-mile trek to our celestial neighbor, where they will test landing capabilities, look for usable water ice , and mor
World's biggest cultivated meat factory is being built in the US
US Believer Meats FDA
submitted by /u/tonymmorley [link] [comments]
The Metaverse: More Hype Than Substance?
submitted by /u/dogonix [link] [comments]
Uploading consciousness to quantum computers
This issue has been bothering me for a week. I think this will be possible in the future. It is thought that quantum computers will enter our lives in 2030 and a huge change will be made in the financial field. I think in 2035 or 2040 the rich (billionaires) will be able to load their consciousness into the universes they have created and live in the fantasy world they want there. In 2050, millio
Retraction Note: Enhancement of oxidation resistance via a self-healing boron carbide coating on diamond particles
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26781-z
Author Correction: Evaluation of heavy metal contamination in copper mine tailing soils of Kitwe and Mufulira, Zambia, for reclamation prospects
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26244-5
Magnitude of depression and its associated factors among patients with diabetes mellitus at public hospitals in Southwest Ethiopia, 2021
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26330-8
Application of Piszkiewicz model on the electron transfer reaction of dithionite ion and bis-(2-pyridinealdoximato)dioxomolybdate(IV) complex
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-24096-7
Single-cell RNA sequencing of immune cells in patients with acute gout
Single Cell RNA 1 3
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-25871-2
Effects of thickened carbonated cola in older patients with dysphagia
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-25926-4
'Major Trustee, Please Prioritize': How NYU's E.R. Favors the Rich
Dozens of doctors said the nonprofit hospital pressured them to give preferential treatment to donors, trustees and their families.
'Tripledemic' Rages On: Fever-Filled Weeks Lie Ahead
R.S.V. has probably peaked, but flu is still surging and Covid-19 cases are rising. Scientists are hopeful next winter will be better.
What Is the Polar Vortex? And Other Cold-Weather Climate Questions
As much of the United States plunges into a deep freeze, scientists continue to debate how rapid Arctic warming is playing a role.
We saw the supermassive black hole at the centre of our galaxy in 2022
Astronomers using the Event Horizon Telescope released a picture in May of Sagittarius A*, the black hole at the centre of the Milky Way
God jul och gott nytt år från oss på redaktionen!
Nu tar redaktionen vid Vetenskap & hälsa julledigt och återkommer den 9 januari. Tills dess önskar vi alla läsare – och lyssnare – en riktigt skön och avkopplande julledighet. Vi ses och hörs på det nya året!
Barn med utländsk bakgrund får mer sällan psykiatrisk behandling
Barn med utländsk bakgrund får inte lika ofta rekommenderade behandlingar för vissa psykiatriska diagnoser, som adhd och depression, jämfört med barn med svenskfödda föräldrar. Det visar forskning från Karolinska Institutet. Inlägget dök först upp på forskning.se .
Barn som förlorat en förälder döljer ofta sorgen
6 av 10 tonåringar som förlorat en förälder i cancer upplever att de inte kunnat sörja ordentligt. Istället har de bitit ihop och gett sken av att allt varit som vanligt. Inlägget dök först upp på forskning.se .
Internet fra rummet er på vej ud i verdens afkroge: Satellitter bliver de nye mobilmaster
PLUS. Tusindvis af nye satellitter sendes i kredsløb tæt på Jorden i disse år. Det vil betyde farvel til dyre og langsomme satellitforbindelser.
Author Correction: Iraq/Afghanistan war lung injury reflects burn pits exposure
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26538-8
Fish see in the dark thanks to extra layers of rod cells in their eyes
Visual tests in nocturnal coral fish reveal how multiple layers of rod cells at the back of the eye enable faster vision in low-light conditions
Daily briefing: T. rex didn't roar — it cooed
Nature, Published online: 20 December 2022; doi:10.1038/d41586-022-04555-x Researchers have never found fossils of dinosaurs' sound-producing organs. Plus, South Korea's lunar orbiter has arrived at the Moon and a historic global deal to save species.
Cheerful chatbots don't necessarily improve customer service
Imagine messaging an artificial intelligence (AI) chatbot about a missing package and getting the response that it would be "delighted" to help. Once the bot creates the new order, they say they are "happy" to resolve the issue. After, you receive a survey about your interaction, but would you be likely to rate it as positive or negative?
Men may not 'perceive' domestic tasks as needing doing in the same way as women, philosophers argue
Philosophers seeking to answer questions around inequality in household labor and the invisibility of women's work in the home have proposed a new theory—that men and women are trained by society to see different possibilities for action in the same domestic environment.
California quake occurred in very seismically active region
The big earthquake that rocked the far north coast of California on Tuesday originated in an area under the Pacific Ocean where multiple tectonic plates collide, creating the state's most seismically active region.
Managing precision and stabilizing local knowledge
In 1911, a meridian circle manufactured by A. Repsold & Söhne in Hamburg, Germany, was installed at the National Astronomical Observatory of Chile under the watch of Friedrich W. Ristenpart, a German astronomer and the observatory's director. The installation was an essential step in Ristenpart's goal of relocating the observatory to gain better sky visibility on the south side of Santiago. As a p
Historisk pessimism hos svenska hushåll
Inlägget dök först upp på forskning.se .
Creative arts and digitial interventions as potential tools in prevention and recovery from the mental health consequences of adverse childhood experiences
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35466-0 Adverse childhood experiences (ACEs) can harm mental health across the lifespan and reduce life expectancy. We provide a commentary of evidence on the health impacts, and how creative arts and digital interventions may support prevention and recovery.
Plasmonic imaging of the layer-dependent electrocatalytic activity of two-dimensional catalysts
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35633-3 Probing the localized electrocatalytic activity of heterogeneous electrocatalysts is crucial. Here, the authors propose a method of imaging the surface charge density and electrocatalytic activity of single two-dimensional electrocatalyst nanosheets.
Why Climate Science Shouldn't Forget to Factor in Brain Health
Scientists agree that climate change will compromise almost every aspect of global health. Why then isn't there more research on the extent of its neurological effects? In order to mitigate and prevent damage, we need to better understand what's in store for our brains.
Barnens rättigheter efter våld behöver stärkas
Inlägget dök först upp på forskning.se .
Huvudvärk förknippad med män visar sig drabba kvinnor hårdare
Klusterhuvudvärk, tidigare kallad Hortons huvudvärk, har länge beskrivits som en mansdominerad sjukdom. Nu visar ny forskning att kvinnor generellt påverkas mer i vardagen än män och oftare har en kronisk variant av den plågsamma huvudvärken. Inlägget dök först upp på forskning.se .
A Science Reporter Asks: 'Where Are the Aliens?'
Kenneth Chang, a Times science reporter, covers a broad range of topics, including nuclear fusion and the conditions favorable to life outside our solar system.
Skeptical Science New Research for Week #51 2022
Open accesss notables: Rabiya Ansari & Jennifer Landin survey climate pedagogy in 57 text books from a 49 year span and find a continuous if unsteady increase in coverage but with no sign of a systematic approach commensurate with the increasingly looming threat, in Coverage of climate change in introductory biology textbooks, 1970–2019 . King Canute's apocryphal object lesson on humility deliver
3D genome organization
Scientific Reports, Published online: 22 December 2022; doi:10.1038/s41598-022-26725-7 Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds and structures, including the nuclear lamina at the nuclear edge, and nucleoli located more internally within the nucleoplasm. Recently, great effort has b
Safeguarding genome integrity during gene-editing therapy in a mouse model of age-related macular degeneration
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35640-4 Undesired chromosomal translocations, vector integrations, and large deletions remain a problem for therapeutic gene editing in vivo. Here, the authors compare the CRISPR-Cas9TX variant with CRISPR-Cas9 and show elimination of chromosomal translocations and reduction of AVV integration when targeting Vegfa f
Modulating glycosphingolipid metabolism and autophagy improves outcomes in pre-clinical models of myeloma bone disease
Nature Communications, Published online: 22 December 2022; doi:10.1038/s41467-022-35358-3 Here, the authors show that the glycosylceramide synthesis inhibitor and FDA approved drug Eliglustat inhibits autophagic degradation of TRAF3 which is a key step for osteoclast differentiation and thereby improves myeloma bone lesions.
Astronomers Have Discovered The 'Poor Old Heart' of The Milky Way
The ghost of our galactic past.
Efforts to Hold Up The Leaning Tower of Pisa Are Going Better Than Expected
"Excellent health" for an 850 year old.
It's Official: NASA's Mars Lander Has Powered Down After 4 Years on Mars
So long and thanks for all the science.
Hydrogen heating trial treats us like guinea pigs – residents
UK Hydrogen 2026 Zero
An English town could be the first to turn off fossil fuel gas, but some residents aren't happy.
Hvem har Danmarksrekorden i affaldsimport?
Deltag i Ingeniørens Julequiz om årets tech-historier og vind flotte præmier!
The science of how to give better gifts
As Christmas approaches, many of us will have spent the last few weeks trying to pick out the perfect presents for friends, family and colleagues. For both giver and receiver, exchanging gifts can be filled with delight – or dread, as a smile slowly fades into a look of feigned enthusiasm. But what does science say about how to avoid unwanted gifts and unpleasant surprises? Ian Sample speaks to Ju
The science of how to give better gifts
As Christmas approaches, many of us will have spent the last few weeks trying to pick out the perfect presents for friends, family and colleagues. For both giver and receiver, exchanging gifts can be filled with delight – or dread, as a smile slowly fades into a look of feigned enthusiasm. But what does science say about how to avoid unwanted gifts and unpleasant surprises? Ian Sample speaks to J
Tre unika förmågor vi trodde bara människor hade
Santino är en av schimpanslegenderna som sköts ihjäl förra veckan på Furuviks djurpark. Han ingick i flera forskningsprogram som har lärt oss att schimpanser behärskar flera förmågor som vi förut trodde var unikt mänskliga.
Økonomisk indsprøjtning i Thulebasen går til vedligehold fremfor forsvar
PLUS. USA har indgået en kontrakt om at vedligeholde Thulebasen for milliarder af kroner.
Reportage fra Grundfos: På vej mod automatiseret metalprint i produktionen
PLUS. Parken af 3D-printere vokser hos Grundfos, der nu udvider med nyt område dedikeret til additive manufacturing.
Greenland's Glaciers Seem to Be Melting Much, Much Faster Than We Thought
We best prepare.
Zelensky Recalled Us to Ourselves
"So much in the world depends on you." Of all the many moving words in President Volodymyr Zelensky's speech to a joint meeting of the U.S. Congress, those eight may have been the most urgent and important. Zelensky came to Washington to speak for his nation. He came to Washington to ask for assistance. But above all, he came to Washington to recall Americans to themselves. He came to say, My emb
Gene therapy restored immune system in children with rare disorder
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Krispy Kreme CEO – Latest massive Robots to start frosting and packing doughnuts- The future is automation to save time and costs
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Stoicism & Artificial Intelligence: Embracing an Age of Unimaginable Change
submitted by /u/johngrady77 [link] [comments]
The Architecture Trends of 2023 According to ChatGPT, an AI-trained Model Bot
submitted by /u/aztroneka [link] [comments]
New Blood Test Accurately Predicts Alzheimer's Years Ahead of First Symptoms
A glimpse into the future.
Brain flexibility may hasten hearing improvements from cochlear implants
Kickstarting the brain's natural ability to adjust to new circumstances, or neuroplasticity, improves how effectively a cochlear implant can restore hearing loss, a new study in deaf rats shows. The investigation, researchers say, may help explain the extreme variation in hearing improvements experienced by implant recipients.
11 Times This Year When Politics Was Funny
This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here . Some very serious and unfunny things happened this year in American politics. Today, though, we are not going to talk about those things. Instead, we will examine a few of the times our elected leader
Cheerful chatbots don't necessarily improve customer service
Humans displaying positive emotions in customer service interactions have long been known to improve customer experience, but researchers wanted to see if this also applied to AI. They conducted experimental studies to determine if positive emotional displays improved customer service and found that emotive AI is only appreciated if the customer expects it, and it may not be the best avenue for co
Infant gene therapy is a breakthrough for Artemis-SCID patients
Ten young children born without functioning immune systems and lacking the ability to fight infections are on track for healthier lives thanks to a new gene therapy treatment.
Brain flexibility may hasten hearing improvements from cochlear implants
Kickstarting the brain's natural ability to adjust to new circumstances, or neuroplasticity, improves how effectively a cochlear implant can restore hearing loss, a new study in deaf rats shows. The investigation, researchers say, may help explain the extreme variation in hearing improvements experienced by implant recipients.
Digital detection of dementia: Using AI to identify undiagnosed dementia
Rising to meet the formidable challenge of the timely diagnosis of dementia, research scientists are conducting the Digital Detection of Dementia study, a real-world evaluation of the use of an artificial intelligence (AI) tool they developed for early identification of Alzheimer's disease and related dementias in primary care, the setting where most adults receive healthcare. Individuals identifi
Drinking 2 or more cups of coffee daily may double risk of heart death in people with severe hypertension
Drinking two or more cups of coffee a day was associated with twice the risk of death from cardiovascular disease among people with severe hypertension compared to non-coffee drinkers, in a study of more than 18,600 men and women in Japan.
Does Dual-N-Back training lead to transfer? Or do you just get better at the game itself?
Studies and anecdotal experiences welcome. submitted by /u/Warrior-Mentality [link] [comments]
Autism Can Make Sleep a Real Challenge. Here Are Some Handy Tips For Bedtime
You're not alone.
UK children with growth disturbance given access to weekly injections
Approval of growth hormone somatrogon fast-tracked by medicines watchdog, replacing need for daily jabs Thousands of children who fail to grow normally because of a hormone deficiency have been given access to a weekly injection for the condition after new guidance from the medicines watchdog. Children with the disorder, known as growth disturbance, have previously required daily injections of th
These Medications Don't Mix Well With Alcohol. An Expert Explains The Risks
Don't take the chance.
Nasal Vaccines Are Here
COVID-19 Vaccine Pfizer
Since the early days of the coronavirus pandemic, a niche subset of experimental vaccines has offered the world a tantalizing promise: a sustained slowdown in the spread of disease . Formulated to spritz protection into the body via the nose or the mouth—the same portals of entry most accessible to the virus itself—mucosal vaccines could head SARS-CoV-2 off at the pass, stamping out infection to
Christmas beetles: Scientists ask Australians for help finding missing festive bugs
Seen as a symbol of Christmas in Australia, the beetles seem to have gone missing in recent years.
Children born today will see literally thousands of animals disappear in their lifetime, as global food webs collapse
submitted by /u/mossadnik [link] [comments]
Do you think people will be able to create their own fantasy world in the future?
Is this possible. Let's say the powerful and rich people in the world will be able to create the fantasy world they want? Will different beings be able to create different places? Will they be able to feel it just like in the world? (smell, touch)? Will there be a destiny in the world they created? Will the creatures they create have intelligence and emotions? What is the earliest this will happe
Hotels say goodbye to daily room cleanings and hello to robots as workers stay scarce
submitted by /u/Gari_305 [link] [comments]
California invests $2.6 billion to build 90,000 EV chargers | There could be 250,000 chargers across the state by 2025.
submitted by /u/mossadnik [link] [comments]
Stem cell transplants may delay disability longer than some MS medications
In people with active secondary progressive multiple sclerosis (MS), hematopoietic stem cell transplants may delay disability longer than some other MS medications, according to a new study. The study involved autologous hematopoietic stem cell transplants, which use healthy blood stem cells from a person's own body to replace diseased cells.
Cluster headache may be more severe in women
While cluster headache is more common in men than in women, a new study suggests that the disorder may be more severe for women.
Climate impacts are increasing; textbooks aren't keeping pace
A new study finds biology textbooks have done a poor job of incorporating material related to climate change. For example, the study found that most textbooks published in the 2010s included less information about climate change than they did in the previous decade — despite significant advances in our understanding of how climate change is influencing ecosystems and the environment.
Metabolic hack makes ocean algae more resilient to 21st century climate change
Scientists provide clear evidence that marine phytoplankton are much more resilient to future climate change than previously thought.
Restoring biodiversity in deforested ranches one tree at a time
For decades, there has been a debate raging in conservation science: what is better when it comes to conservation or landscape rehabilitation: a single large or several small habitat areas?
Restoring biodiversity in deforested ranches one tree at a time
For decades, there has been a debate raging in conservation science: what is better when it comes to conservation or landscape rehabilitation: a single large or several small habitat areas?
Gene therapy restored immune system in children with rare disorder
Artemis-SCID Gene SCID
Ten children with the rare condition Artemis-deficient severe combined immunodeficiency had their immune systems either partially or fully restored with gene-replacement therapy
Neutron experiments reveal what maintains good function in bones
Around 500 million years ago, early vertebrates in the seas became fish, adopting an inner skeleton and a flexible spine based on a nanocomposite of fibers and mineral, known as bone material. This "invention" of evolution was so successful that the basic structure was also adopted for later vertebrates that lived on land.
To Grandmother's TikTok We Go
Nothing about Barbara Costello's favorite Christmas recipe is all that fancy. The overnight breakfast casserole she makes every year doesn't call for much more than eggs, milk, sausage, cheese, and bread thrown into a baking dish—a recipe she clipped from a local newspaper nearly 50 years ago. But in the years since Costello first cooked it, that humble casserole has become a hallmark of her grow
A Chatbot's Predictions for the Future of AI
This is an edition of Up for Debate, a newsletter by Conor Friedersdorf. On Wednesdays, he rounds up timely conversations and solicits reader responses to one thought-provoking question. Later, he publishes some thoughtful replies. Sign up for the newsletter here. Question of the Week To complete this week's question I had a conversation with OpenAI's chatbot, GPT-3 (which anyone can try ). "Ever
Heart health tip for older adults in 2023: Step it up a bit
The evidence-based health benefits of walking continue to accumulate, according to ongoing research by a physical activity epidemiologist.
At the edge of graphene-based electronics
Researchers developed a new graphene-based nanoelectronics platform compatible with conventional microelectronics manufacturing, paving the way for a successor to silicon.
In a 1st, baby's heart defect successfully treated with injected stem cells
Baby Stem Cells Heart
Doctors treated a baby's heart defect with donated stem cells.
NASA's Perseverance rover deposits first sample on Mars surface
A titanium tube containing a rock sample is resting on the Red Planet's surface after being placed there on Dec. 21 by NASA's Perseverance Mars rover. Over the next two months, the rover will deposit a total of 10 tubes at the location, called "Three Forks," building humanity's first sample depot on another planet. The depot marks a historic early step in the Mars Sample Return campaign.
Drying process could be key step in development of life
One-hundred fifty years ago, Charles Darwin speculated that life likely originated in a warm little pond. There, Darwin supposed, chemical reactions and the odd lightning strike might have led to chains of amino acids that, over time, became more and more complex until the beginnings of life emerged.
Biodiversity: One way to help countries stick to their commitments to restore nature
When a hydropower dam in Argentina threatened to wipe out the hooded grebe, a bird found nowhere else on Earth, a local fishing community turned to the law for help.
Temporary child-welfare placements target non-white children disproportionately
Nationwide, children who are removed from their homes by child protective services for fewer than 30 days are overwhelmingly Asian American, Black or Native American, raising questions about the impartiality of states' child welfare systems and policies, according to a Rutgers study.
Assembly begins on NASA's next tool to study exoplanets
Scientists have discovered more than 5,000 exoplanets, or planets outside our solar system. As technologies for studying these worlds continue to advance, researchers may someday be able to search for signs of life on exoplanets that are similar in size, composition, and temperature to Earth. But to do that they'll need new tools, like those being tested on the Coronagraph Instrument on NASA's Nan
Facial-Recognition Tech Gets Lawyer Booted From Radio City Music Hall
MSG Rockettes RCMH
Facial recognition technology is everywhere today, from airports to the phone in your pocket. One place you might not expect to encounter it is a popular concert venue like Radio City Music Hall in New York. However, Madison Square Garden Entertainment, the operator of this and other facilities, recently used facial recognition to single out and eject a woman from its famed Rockettes show. Her cr
Wildfire threats not commonly disclosed by US firms despite risk to economy
U.S. firms rarely report their wildfire risks in required federal filings and instead bury such risks in nonspecific risk disclosures, according to new research.
Neutron experiments reveal what maintains bones in good function
What keeps bones able to remodel themselves and stay healthy? A team has discovered clues to the key function of non-collagen protein compounds and how they help bone cells react to external load. The scientists used fish models to examine bone samples with and without bone cells to elucidate differences in microstructures and the incorporation of water. Using 3D neutron tomography they succeeded
Study links metabolism changes in certain brain cells to Huntington's disease
A research team has linked the mutation that causes Huntington's disease to developmental deficits in the brain's oligodendrocyte cells that are caused by changes in metabolism. They found that high doses of thiamine and biotin can restore normal processes.
Drying process could be key step in development of life
One-hundred fifty years ago, Charles Darwin speculated that life likely originated in a warm little pond. There, Darwin supposed, chemical reactions and the odd lightning strike might have led to chains of amino acids that, over time, became more and more complex until the beginnings of life emerged.
Researchers use quantum mechanics to see objects without looking at them
We see the world around us because light is being absorbed by specialized cells in our retina. But can vision happen without any absorption at all—without even a single particle of light? Surprisingly, the answer is yes.
Wildfire threats not commonly disclosed by U.S. firms despite risk to economy
Wildfires in the United States, especially in western states, increasingly pose a significant risk to entire communities, often destroying homes, businesses and lives. When wildfires sweep through a region, they also affect the economy as a whole, decreasing U.S. firms' values to stockholders when businesses incur physical damage, cause or experience supply chain issues, or lose employees.
What is an aftershock? Learn about the smaller earthquakes impacting Northern California.
Northern California residents awoke early Tuesday to a magnitude 6.4 earthquake that killed at least two people, damaged infrastructure and cut off power for tens of thousands.
Chile's ALMA observatory resumes work after cyberattack
Chile ALMA Cyberattack
The ALMA telescope in the Chilean Andes has resumed operations nearly two months after shuttering due to a cyberattack, the observatory said Wednesday.
Europe's access to space in jeopardy after Vega-C rocket failure
Flights of the new European Vega-C rocket have been suspended pending an investigation into an overnight launch failure, French firm Arianespace said Wednesday, leaving Europe with few avenues into space.
EXPLAINER: Arctic blast sweeps US, bomb cyclone possible
An arctic blast is bringing extreme cold, heavy snow and intense wind across much of the U.S. this week—just in time for the holidays.
NASA retires InSight Mars lander mission after years of science
NASA's InSight mission has ended after more than four years of collecting unique science on Mars.
Researchers discover 'dormant' magnetosome genes in non-magnetic bacteria
Magnetic bacteria can align their movement with the Earth's magnetic field thanks to chains of magnetic nanoparticles inside their cells. The blueprints for making and linking these magnetosomes are stored in the bacteria's genes.
Study finds anger over COVID-19 layoffs keeping hospitality workers from returning to jobs
Researchers at the University of Houston Conrad N. Hilton College of Global Hospitality Leadership say many skilled hospitality workers who were furloughed or laid off during the COVID-19 pandemic are angry and unlikely to return to the industry.
Researchers discover 'dormant' magnetosome genes in non-magnetic bacteria
Magnetic bacteria can align their movement with the Earth's magnetic field thanks to chains of magnetic nanoparticles inside their cells. The blueprints for making and linking these magnetosomes are stored in the bacteria's genes.
Study traces shared and unique cellular hallmarks found in 6 neurodegenerative diseases
A perplexing range of neurodegenerative diseases are known to attack distinct regions of the brain, causing severe cognitive and motor deficit. The combined impact of these (generally fatal) diseases has inflicted a devastating toll on society. New insights suggest many of these afflictions have their origin in a constellation of common processes, which play out in different ways as each disease d
Money Will Kill ChatGPT's Magic
Arthur C. Clarke once remarked, "Any sufficiently advanced technology is indistinguishable from magic." That ambient sense of magic has been missing from the past decade of internet history. The advances have slowed. Each new tablet and smartphone is only a modest improvement over its predecessor. The expected revolutions—the metaverse, blockchain, self-driving cars—have plodded along, always wit
The Atlantic Announces Hire of Yair Rosenberg as Staff Writer
Yair Rosenberg , who has been a contributing writer with The Atlantic and the author of the Deep Shtetl newsletter, is joining The Atlantic as a staff writer. Yair is best known for his coverage about the intersection of politics, culture, and religion, having covered national and international politics; online discourse in an age of disinformation and conspiracy; and the omnipresence of antisemi
Scientists highlight safe access to the outdoors with naming of new plant species
A new species of Australian bush tomato described from the Garrarnawun Lookout in Judbarra National Park provides a compelling example of the need to provide equal and safe access to natural places. Bucknell University postdoctoral fellow Tanisha Williams and biology professor Chris Martine led the study following a chance encounter with an unusual population of plants during a 2019 research exped
Scientists highlight safe access to the outdoors with naming of new plant species
A new species of Australian bush tomato described from the Garrarnawun Lookout in Judbarra National Park provides a compelling example of the need to provide equal and safe access to natural places. Bucknell University postdoctoral fellow Tanisha Williams and biology professor Chris Martine led the study following a chance encounter with an unusual population of plants during a 2019 research exped
how much does my undergrad major matter + should i transfer
i've become really interested in cognitive science but my current school doesn't have it as a major (i'm a freshman). i entered as a philosophy and economics double major, but now i'm going to drop the economics major and take neuro/psych/linguistics classes instead. i'm not sure if i should transfer schools to a different school though, my current qualms are a couple non-academic ones and also t
The 60-Second Podcast Takes a Short Break–but Wait, There's More
Scientific American's short-form podcast has been going for 16 years, 3 months, and 7 days, counting today, but it's time for us to evolve.
The physical intelligence of ant and robot collectives
Researchers took inspiration from ants to design a team of relatively simple robots that can work collectively to perform complex tasks using only a few basic parameters.
The 60-Second Podcast Takes a Short Break–but Wait, There's More
Scientific American's short-form podcast has been going for 16 years, 3 months, and 7 days, counting today, but it's time for us to evolve.
When it comes to disaster prevention policies, who can we trust?
A dilemma for policymakers: The world needs to start preparing for the weather-related disasters happening with increasing frequency and intensity due to climate change. World leaders are proposing measures to quickly reduce emissions and build resilience. Yet, many voters oppose spending on measures to prevent or mitigate disaster.
New fossil foot analysis reveals the surprising and varied lifestyles of dinosaur bird ancestors
Have you ever eaten chicken feet? If you haven't, you might be surprised to learn there's actually quite a bit of flesh down there. And scales too! They're wonderful—and informative—pieces of engineering.
Not all mushrooms are alike: How fine underground braids could remedy heavy metal contamination
Among domestic mushroom pickers in Germany it goes without saying that many edible mushrooms in our forests are still contaminated with radionuclides as a result of the 1986 Chernobyl nuclear disaster. Less well known is that mushrooms can also accumulate other heavy metals.
Non-inertial torques and the Euler equation
Classical mechanics is the framework for studying motion of objects under the influence of forces. Its domain of applicability is limited to the macroscopic world (i.e., not applicable in the atomic/subatomic world) and to motion of objects with speeds much smaller than the speed of light.
Constrained future brightening of solar radiation in China and its implication for solar power
Surface solar radiation (Rs) data is essential information for the development of solar power usage to mitigate the ongoing climate change. To meet China's carbon neutrality goal, China has invested and planned heavily in solar photovoltaic systems.
Large Hadron Collider ATLAS moves into top gear for Run 3
After over three years of upgrade and maintenance work, the Large Hadron Collider began its third period of operation (Run 3) in July 2022. Since then, the world's most powerful particle accelerator has been colliding protons at a record-breaking energy of 13.6 TeV. The ATLAS collaboration has just released its first measurements of these record collisions, studying data collected in the first hal
Disproportionately large amounts of carbon accumulate at the bottom of deep-sea trenches, research shows
The Earth's deep-sea trenches are some of the least explored places on Earth—as they are very difficult to access, are pitch black and the pressure is extremely high. Collecting samples and making reliable measurements of the processes that regulate the turnover of organic material in the deep is therefore difficult.
New fossil foot analysis reveals the surprising and varied lifestyles of dinosaur bird ancestors
Have you ever eaten chicken feet? If you haven't, you might be surprised to learn there's actually quite a bit of flesh down there. And scales too! They're wonderful—and informative—pieces of engineering.
Not all mushrooms are alike: How fine underground braids could remedy heavy metal contamination
Among domestic mushroom pickers in Germany it goes without saying that many edible mushrooms in our forests are still contaminated with radionuclides as a result of the 1986 Chernobyl nuclear disaster. Less well known is that mushrooms can also accumulate other heavy metals.
The physical intelligence of ant and robot collectives
Researchers took inspiration from ants to design a team of relatively simple robots that can work collectively to perform complex tasks using only a few basic parameters.
How nerve and vascular cells coordinate their growth
Nerve cells need a lot of energy and oxygen. They receive both through the blood. This is why nerve tissue is usually crisscrossed by a large number of blood vessels. But what prevents neurons and vascular cells from getting in each other's way as they grow? Researchers have identified a mechanism that takes care of this.
Climate-change content shrinks in US university textbooks
Nature, Published online: 21 December 2022; doi:10.1038/d41586-022-04487-6 Sections on climate change have become shorter and moved farther back in biology textbooks since the 2000s.
UK accelerates work on alternative to EU research programme
Rishi Sunak wants to speed up 'plan B' in place of British participation in Horizon Europe
Multi-heterointerfaces for selective and efficient urea production
A major impediment to industrial urea synthesis is the lack of catalysts with high selectivity and activity. Prof. Yuliang Li (Institute of Chemistry, Chinese Academy of Sciences) and coworkers reported a new catalyst system suitable for the highly selective synthesis of industrial urea by in-situ growth of graphdiyne on the surface of cobalt-nickel mixed oxides.
More than fun and games: Celebrations can increase perceived social support
Making an intentional effort to recognize positive life events and achievements while gathering for food and drink will leave you feeling more socially supported, new research shows.
Team develops graphene-based nanoelectronics platform
A pressing quest in the field of nanoelectronics is the search for a material that could replace silicon. Graphene has seemed promising for decades. But its potential has faltered along the way, due to damaging processing methods and the lack of a new electronics paradigm to embrace it. With silicon nearly maxed out in its ability to accommodate faster computing, the next big nanoelectronics platf
Social media may prevent users from reaping the creative rewards of profound boredom
People who turn to social media to escape from superficial boredom are unwittingly preventing themselves from progressing to a state of profound boredom, which may open the door to more creative and meaningful activity, a new study of the COVID pandemic shows.
The other paleo diet: Rare discovery of dinosaur remains preserved with its last meal
Microraptor was an opportunistic predator, feeding on fish, birds, lizards — and now small mammals. The discovery of a rare fossil reveals the creature was a generalist carnivore in the ancient ecosystem of dinosaurs.
Scientists discover a novel photophysical mechanism that has achieved record-breaking efficiency for organic photovoltaics
Organic photovoltaics (OPVs) are a promising, economical, next-generation solar cell technology for scalable clean energy and wearable electronics. But the energy conversion loss due to the recombination of photogenerated charge carriers in OPVs has hindered further enhancement of their power conversion efficiency (PCE). Recently, researchers from City University of Hong Kong (CityU) overcame this
Artificial intelligence tool predicts which patients with dystonia respond to Botox treatment with 96 percent accuracy
An artificial intelligence tool called DystoniaBoTXNet predicted which patients with dystonia would benefit from botulinum toxin injections with 96.3% accuracy. DystoniaBoTXNet could be a tool to aid clinical decision-making and address some of the issues patients with dystonia face with overtreatment and undertreatment with this first-line therapy.
Researchers develop new tool for studying multiple characteristics of a single cell
Single Cell RNA 1 3
Researchers have developed new software that integrates a variety of information from a single cell, allowing researchers to see how one change in a cell can lead to several others and providing important clues for pinpointing the exact causes of genetic-based diseases.
'Better picker-upper' absorbs three times more liquid than a paper towel
When it comes to kitchen spills, paper towels and rags do the job. But using a hydrogel — a gelatin-like material in the form of a dry sheet — researchers have crafted a better picker-upper that absorbs and holds about three times more water-based liquid. The method produces an absorbent, foldable, and cuttable 'gel sheet' that may one day find use in our kitchens or operating rooms to soak up l
Cracking the mystery behind a deadly brain cancer
Brain Cancer CSHL
Glioblastoma is a deadly brain cancer with a grim prognosis. Unlike most cancers, it still grows in the presence of the P53 protein. For decades, scientists have been unable to crack the case . . . until now. Scientists have discovered a protein known as BRD8 has gone rogue in glioblastoma, crippling P53. The finding could help turn this deadly cancer into a treatable disease.
Brain circuit that converts spatial goals to escape actions discovered
Researchers have revealed a brain mechanism that mice use to instinctively escape to shelter when faced with a threat. This is the first time that neuroscientists have been able to find such a clear link between spatial goals and actions.
Radiation damage to paternal DNA is passed on to offspring
Damage to the paternal genome of the nematode Caenorhabditis elegans cannot be repaired and is instead passed on to its offspring, while the female egg repairs or limits the damage.
Topological supermodes in photonic crystal fiber | Science Advances
Abstract Topological states enable robust transport within disorder-rich media through integer invariants inextricably tied to the transmission of light, sound, or electrons. However, the challenge remains to exploit topological protection in a length-scalable platform such as optical fiber. We demonstrate, through both modeling and experiment, optical fiber that hosts topological supermodes acro
Rapid assessment of adult abundance and demographic connectivity from juvenile kin pairs in a critically endangered species | Science Advances
Abstract The viability of spatially structured populations depends on the abundance and connectivity between subpopulations of breeding adults. Yet, for many species, both are extremely difficult to assess. The speartooth shark is a critically endangered elasmobranch inhabiting tropical rivers with only three adults ever recorded in Australia. Close-kin mark-recapture models, informed by sibling
Anomalously field-susceptible spin clusters emerging in the electric-dipole liquid candidate κ-(ET)2Hg(SCN)2Br | Science Advances
Abstract Mutual interactions in many-body systems bring about various exotic phases, among which liquid-like states failing to order due to frustration are of keen interest. The organic system with an anisotropic triangular lattice of molecular dimers, κ-(ET) 2 Hg(SCN) 2 Br, has been suggested to host a dipole liquid arising from intradimer charge-imbalance instability, possibly offering an unpre
Diabatic and adiabatic transitions between Floquet states imprinted in coherent exciton emission in monolayer WSe2 | Science Advances
Abstract Floquet engineering is a promising way of controlling quantum system with photon-dressed states on an ultrafast time scale. So far, the energy structure of Floquet states in solids has been intensively investigated. However, the dynamical aspects of the photon-dressed states under ultrashort pulse have not been explored yet. Their dynamics become highly sensitive to the driving field tra
Stabilized COre gene and Pathway Election uncovers pan-cancer shared pathways and a cancer-specific driver | Science Advances
Abstract Approaches systematically characterizing interactions via transcriptomic data usually follow two systems: (i) coexpression network analyses focusing on correlations between genes and (ii) linear regressions (usually regularized) to select multiple genes jointly. Both suffer from the problem of stability: A slight change of parameterization or dataset could lead to marked alterations of o
Nutrient uptake plasticity in phytoplankton sustains future ocean net primary production | Science Advances
Abstract Annually, marine phytoplankton convert approximately 50 billion tons of dissolved inorganic carbon to particulate and dissolved organic carbon, a portion of which is exported to depth via the biological carbon pump. Despite its important roles in regulating atmospheric carbon dioxide via carbon sequestration and in sustaining marine ecosystems, model-projected future changes in marine ne
Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system | Science Advances
Abstract The oral protease inhibitor nirmatrelvir is of key importance for prevention of severe coronavirus disease 2019 (COVID-19). To facilitate resistance monitoring, we studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from nirmatrelvir in cell culture. Resistant variants harbored combinations of substitutions in the SARS-CoV-2 main protease (Mpro). Reverse genetics
Dissecting the recruitment and self-organization of αSMA-positive fibroblasts in the foreign body response | Science Advances
Abstract The foreign body response (FBR) is a clinically relevant issue that can cause malfunction of implanted medical devices by fibrotic encapsulation. Whereas inflammatory aspects of the FBR have been established, underlying fibroblast-dependent mechanisms remain unclear. We here combine multiphoton microscopy with ad hoc reporter mice expressing α–smooth muscle actin (αSMA) protein to determ
Native holdup (nHU) to measure binding affinities from cell extracts | Science Advances
Abstract Characterizing macromolecular interactions is essential for understanding cellular processes, yet most methods currently used to detect protein interactions from cells are qualitative. Here, we introduce the native holdup (nHU) approach to estimate equilibrium binding constants of protein interactions directly from cell extracts. Compared to other pull-down–based assays, nHU requires les
Genomic imprinting-like monoallelic paternal expression determines sex of channel catfish | Science Advances
Abstract The X and Y chromosomes of channel catfish have the same gene contents. Here, we report allelic hypermethylation of the X chromosome within the sex determination region (SDR). Accordingly, the X-borne hydin-1 gene was silenced, whereas the Y-borne hydin-1 gene was expressed, making monoallelic expression of hydin-1 responsible for sex determination, much like genomic imprinting. Treatmen
Mechanically robust stretchable semiconductor metallization for skin-inspired organic transistors | Science Advances
Abstract Despite recent remarkable advances in stretchable organic thin-film field-effect transistors (OTFTs), the development of stretchable metallization remains a challenge. Here, we report a highly stretchable and robust metallization on an elastomeric semiconductor film based on metal-elastic semiconductor intermixing. We found that vaporized silver (Ag) atom with higher diffusivity than oth
Single "Swiss-roll" microelectrode elucidates the critical role of iron substitution in conversion-type oxides | Science Advances
Abstract Advancing the lithium-ion battery technology requires the understanding of electrochemical processes in electrode materials with high resolution, accuracy, and sensitivity. However, most techniques today are limited by their inability to separate the complex signals from slurry-coated composite electrodes. Here, we use a three-dimensional "Swiss-roll" microtubular electrode that is incor
3D morphable systems via deterministic microfolding for vibrational sensing, robotic implants, and reconfigurable telecommunication | Science Advances
Abstract DNA and proteins fold in three dimensions (3D) to enable functions that sustain life. Emulation of such folding schemes for functional materials can unleash enormous potential in advancing a wide range of technologies, especially in robotics, medicine, and telecommunication. Here, we report a microfolding strategy that enables formation of 3D morphable microelectronic systems integrated
Ultra-broadband all-optical sampling of optical waveforms | Science Advances
Abstract Optical-field sampling techniques provide direct access to the electric field of visible and near-infrared light. The existing methods achieve the necessary bandwidth using highly nonlinear light-matter interaction that involves ionization of atoms or generation of charge carriers in solids. We demonstrate an alternative, all-optical approach for measuring electric fields of broadband la
Tandem metalloenzymes gate plant cell entry by pathogenic fungi | Science Advances
Abstract Global food security is endangered by fungal phytopathogens causing devastating crop production losses. Many of these pathogens use specialized appressoria cells to puncture plant cuticles. Here, we unveil a pair of alcohol oxidase–peroxidase enzymes to be essential for pathogenicity. Using Colletotrichum orbiculare , we show that the enzyme pair is cosecreted by the fungus early during
TAp63 determines the fate of oocytes against DNA damage | Science Advances
Abstract Cyclophosphamide and doxorubicin lead to premature ovarian insufficiency as an off-target effect. However, their oocyte death pathway has been debated. Here, we clarified the precise mechanism of ovarian depletion induced by cyclophosphamide and doxorubicin. Dormant oocytes instead of activated oocytes with high PI3K activity were more sensitive to cyclophosphamide. Checkpoint kinase 2 (
Deep top-down proteomics revealed significant proteoform-level differences between metastatic and nonmetastatic colorectal cancer cells | Science Advances
Abstract Understanding cancer metastasis at the proteoform level is crucial for discovering previously unknown protein biomarkers for cancer diagnosis and drug development. We present the first top-down proteomics (TDP) study of a pair of isogenic human nonmetastatic and metastatic colorectal cancer (CRC) cell lines (SW480 and SW620). We identified 23,622 proteoforms of 2332 proteins from the two
Use of intercellular proximity labeling to quantify and decipher cell-cell interactions directed by diversified molecular pairs | Science Advances
1 3 Cell RNA Myelin
Abstract FucoID is an intercellular proximity labeling technique for studying cell-cell interactions (CCIs) via fucosyltransferase (FT)–meditated fucosyl-biotinylation, which has been applied to probe antigen-specific dendritic cell (DC)–T cell interactions. In this system, bait cells of interest with cell surface–anchored FT are used to capture the interacting prey cells by transferring a biotin
Interference of flagellar rotation up-regulates the expression of small RNA contributing to Bordetella pertussis infection | Science Advances
Abstract Bacterial small RNAs (sRNAs) posttranscriptionally regulate gene expressions involved in various biological processes, including pathogenicity. Our previous study identified sRNAs, the expression of which was up-regulated in Bordetella pertussis , the causative agent of whooping cough, upon tracheal colonization of the bacteria; however, their roles in bacterial infection remain unknown.
Triboelectric wetting for continuous droplet transport | Science Advances
Abstract Manipulating liquid is of great significance in fields from life sciences to industrial applications. Owing to its advantages in manipulating liquids with high precision and flexibility, electrowetting on dielectric (EWOD) has been widely used in various applications. Despite this, its efficient operation generally needs electrode arrays and sophisticated circuit control. Here, we develo
Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization | Science Advances
Abstract Extracellular matrix (ECM) interactions regulate both the cell transcriptome and proteome, thereby determining cell fate. Traumatic heterotopic ossification (HO) is a disorder characterized by aberrant mesenchymal lineage (MLin) cell differentiation, forming bone within soft tissues of the musculoskeletal system following traumatic injury. Recent work has shown that HO is influenced by E
Nanoparticle delivery of CD40 siRNA suppresses alloimmune responses by inhibiting activation and differentiation of DCs and macrophages | Science Advances
Abstract CD40 is an important costimulatory molecule expressed on antigen-presenting cells (APCs) and plays a critical role for APC activation, offering a promising therapeutic target for preventing allograft rejection. Here, we developed a biodegradable nanoparticle small interfering RNA delivery system (si CD40 /NPs) to effectively deliver CD40 siRNA (si CD40 ) into hematopoietic stem cells (HS
Crowder-directed interactions and conformational dynamics in multistimuli-responsive intrinsically disordered protein | Science Advances
Abstract The consequences of crowding on the dynamic conformational ensembles of intrinsically disordered proteins (IDPs) remain unresolved because of their ultrafast motion. Here, we report crowder-induced interactions and conformational dynamics of a prototypical multistimuli-responsive IDP, Rec1-resilin. The effects of a range of crowders of varying sizes, forms, topologies, and concentrations
Mechanisms of DNA opening revealed in AAA+ transcription complex structures | Science Advances
Abstract Gene transcription is carried out by RNA polymerase (RNAP) and requires the conversion of the initial closed promoter complex, where DNA is double stranded, to a transcription-competent open promoter complex, where DNA is opened up. In bacteria, RNAP relies on σ factors for its promoter specificities. Using a special form of sigma factor (σ 54 ), which forms a stable closed complex and r
GABA signaling triggered by TMC-1/Tmc delays neuronal aging by inhibiting the PKC pathway in C. elegans | Science Advances
Abstract Aging causes functional decline and degeneration of neurons and is a major risk factor of neurodegenerative diseases. To investigate the molecular mechanisms underlying neuronal aging, we developed a new pipeline for neuronal proteomic profiling in young and aged animals. While the overall translational machinery is down-regulated, certain proteins increase expressions upon aging. Among
Discovery of super–insecticide-resistant dengue mosquitoes in Asia: Threats of concomitant knockdown resistance mutations | Science Advances
Abstract Aedes aegypti (Linnaeus, 1762) is the main mosquito vector for dengue and other arboviral infectious diseases. Control of this important vector highly relies on the use of insecticides, especially pyrethroids. The high frequency (>78%) of the L982W substitution was detected at the target site of the pyrethroid insecticide, the voltage-gated sodium channel (Vgsc) of A. aegypti collected f
Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel | Science Advances
Abstract Salivary gland acinar cells are severely depleted after radiotherapy for head and neck cancer, leading to loss of saliva and extensive oro-digestive complications. With no regenerative therapies available, organ dysfunction is irreversible. Here, using the adult murine system, we demonstrate that radiation-damaged salivary glands can be functionally regenerated via sustained delivery of
How to Help People with Memory Loss Enjoy the Holidays
As we gather for holidays, asking people with memory loss about past holiday events and traditions affects well-being and feelings of closeness
Seven years of carbon-based electrochemical catalysts: Where we are and where we need to go
The abundant carbon on Earth might offer a rich, renewable resource for clean, sustainable energy. The technology—called carbon-based electrochemical catalysis—that could make green energy conversion possible exists, according to an international collaboration investigating recent advancements, but is not ready for broad application.
Palau's Rock Islands harbor heat-resistant corals
Ocean warming is driving an increase in the frequency and severity of marine heatwaves, causing untold damage to coral reefs. Tropical corals, which live in symbiosis with tiny single-celled algae, are sensitive to high temperatures, and exhibit a stress response called bleaching when the ocean gets too hot.
Palau's Rock Islands harbor heat-resistant corals
Ocean warming is driving an increase in the frequency and severity of marine heatwaves, causing untold damage to coral reefs. Tropical corals, which live in symbiosis with tiny single-celled algae, are sensitive to high temperatures, and exhibit a stress response called bleaching when the ocean gets too hot.
How to Help People with Memory Loss Enjoy the Holidays
As we gather for holidays, asking people with memory loss about past holiday events and traditions affects well-being and feelings of closeness
Rapid evolution of spermatogenesis
Evolutionary pressure across male mammals to guarantee the procreation of their own offspring led to a rapid evolution of the testicle. Bioinformatic studies show that this pressure particularly accelerated the evolution of later stages of sperm formation.
Spatial lung cell atlas offers insights into disease and immune function
Researchers have genetically profiled nearly 200,000 cells from lungs, mapping their precise locations in tissue to discover an unexpected new immune niche in our airways
Carbon, soot and particles from combustion end up in deep-sea trenches
New research shows that disproportionately large amounts of carbon accumulate at the bottom of deep-sea trenches. The trenches may thus play an important role for deep-sea storage of organic material — and thus for the atmospheric Co2 balance.
What constitutes teacher expertise? New research points to the answer
Research has identified key characteristics and practices of expert teachers.
Acids help against airborne viruses
A new study shows that aerosols in indoor air can vary in acidity. This acidity determines how long viruses remain infectious in the air — with profound implications for virus transmission and strategies to contain it.
Cooking Pine Needles?? | Moonshiners
#shorts #discovery #moonshiners From: Discovery
Mars InSight lander sends bittersweet goodbye selfie after 4 years of revealing the Red Planet's mysteries
The robot that made 'Marsquake' a part of our vocabulary may finally be dead in the Martian dust.
Many mosquitoes are now insecticide-resistant in Vietnam and Cambodia
More than three-quarters of Aedes aegypti mosquitoes sampled in Vietnam and Cambodia were from strains that are extremely resistant to pyrethroid insecticides
Ask for payment before or after? The effects of timing in pay-what-you-want pricing
Researchers from Rollins College, University of Cambridge, and Harvard University published a new Journal of Marketing article that examines the timing effects of payment requests in pay-what-you-want pricing situations.
Covid: ongoing loss of smell may be caused by nasal cell destruction
Research into immune response sheds light on question of whether virus damages nose or brain Millions of people who lost their sense of smell after contracting Covid may have an ongoing, abnormal immune response that destroys cells in the nose, researchers say. Doctors analysed nasal tissue from Covid patients and found that those with long-term problems with their sense of smell had inflammation
US college biology textbooks failing to address climate crisis, study says
Coverage of climate crisis solutions is slim in textbooks, with many references moving to the back pages US college-level biology textbooks miss the mark on offering solutions to the climate crisis, according to a new analysis of books over the last 50 years. Fewer than three pages in a typical 1,000-page biology textbook from recent decades address climate change, according to the new study , de
Merry or scary? Santa's 'Ho ho ho' mirrors our own ambiguous relationship to laughter
Here it is again: the merry, festive Christmas season with its glitter balls, tinsel and the typical "Ho Ho Ho!" Holding onto his red belly, Santa grins and laughs at us from everywhere. Like Halloween pumpkins and clowns, Santa is one of our most popular cultural symbols associated with laughter.
Nvidia RTX Ada Titan Leaks Show Quad-Slot Monstrosity, Dual 16-pin Connectors
(Credit: Moores Law is Dead) When Nvidia launched its 40-series Ada Lovelace GPUs, it conspicuously revealed the 4090 does not use the full-fat AD102 silicon. Instead, it's a cut-down version, meaning Nvidia left some horsepower waiting in the wings just in case it needed it. We always figured that would be a 4090 Ti, launched when necessary to blunt an attack from AMD. Now it seems like the comp
A Drone Flew a Human Lung Across Toronto for Emergency Transplant
Big companies like Amazon and Walmart have recently been testing drone delivery , flying customers' orders to them through traffic-less skies. Given the volume of packages now circulating through the mail system every day (and the Amazon delivery vehicles constantly clogging up urban streets), it's important that companies find better ways to get goods to buyers. But while ferrying paper towels o
New insights into intrinsically disordered proteins and how they change shape within a cell
A collaboration of scientists from RMIT, ANSTO and the CSIRO has published pioneering research that brings new insights into intrinsically disordered proteins and protein regions (IDPs)/ (IDRs) and how they behave under various physiological processes.
Metabolic hack makes ocean algae more resilient to 21st century climate change
A study published in Science Advances by an international team of scientists provides clear evidence that marine phytoplankton are much more resilient to future climate change than previously thought.
New insights into intrinsically disordered proteins and how they change shape within a cell
A collaboration of scientists from RMIT, ANSTO and the CSIRO has published pioneering research that brings new insights into intrinsically disordered proteins and protein regions (IDPs)/ (IDRs) and how they behave under various physiological processes.
Climate impacts are increasing; textbooks aren't keeping pace
A new study from North Carolina State University finds that biology textbooks have done a poor job of incorporating material related to climate change. For example, the study found that most textbooks published in the 2010s included less information about climate change than they did in the previous decade—despite significant advances in our understanding of how climate change is influencing ecosy
Cross-cultural study examines maternal attitudes and infant development
Mothers in the samples from the U.K. and Uganda have different attitudes toward parenting, but while on a group level the experience and development of their infants sometimes aligns with parenting attitudes, surprisingly, it did not always show such variation, according to a new study published this week in the open-access journal PLOS ONE by Eve Holden and Katie Slocombe of University of York, U
Metabolic hack makes ocean algae more resilient to 21st century climate change
A study published in Science Advances by an international team of scientists provides clear evidence that marine phytoplankton are much more resilient to future climate change than previously thought.
Exploring perceptions of faces paired with fake news on Twitter
In experiments using made-up tweets, participants rated the trustworthiness of faces paired with positive news headlines more highly than faces paired with negative headlines.
What constitutes teacher expertise? New research points to the answer
In the largest ever review of teacher expertise, including data from over 1,000 teachers from around the world in primary and secondary school education, 73 features common to many expert teachers have been identified.
Image: Snowy Alps from Copernicus satellite
Snow cover is a vital source of water for industry, agriculture and human consumption. Records show that last winter's snow cover in the Alps was less than it has been since 2001. This Copernicus Sentinel-3 image captured on December 18, 2022 shows the wide-coverage of snowfall which hopefully bodes well for the coming year.
Photos: Argentina's World Cup Victory Celebration
Argentina World Cup
After Argentina's national football team beat France's 4–2 on penalties in Qatar, winning their third World Cup title, they returned to Buenos Aires to attend a victory celebration, planning to tour the streets of the city in an open bus. Millions of fans gathered in the streets and squares to cheer for their treasured team led by captain Lionel Messi. But the huge number of people exceeded expec
Nazca Lines: Mysterious geoglyphs in Peru
These huge earthen creations in a Peruvian desert depict animals, plants and fantastic creatures.
Government censorship and lack of accountability – Korea
First of all, I'd like to start by saying prayers to the people that were affected by the horrifying events in South Korea during Halloween, it truly was a frightening situation. After the disaster unfolded, the situation was incredibly tense in the country. The government was actively trying to silence all voices speaking out with regard to the tragedy that transpired on Halloween. This led many
Scientists Created Male and Female Cells from a Single Person
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Hydrogen is not the answer to energy crisis, Britain finds. New report found hydrogen is not yet ready for prime time. Lawmakers see hydrogen playing only a niche role in the energy transition. "It seems likely that any future use of hydrogen will be limited rather than universal."
submitted by /u/mafco [link] [comments]
Designer Babies and Lab Babies a solution to population collapse?
submitted by /u/Laserous [link] [comments]
Mid life career change – what to avoid with a view to AI/automation
I want this to be a more general discussion but i'll give some details. I'm 40. So, my window is 25 years. My main idea right now is social work. It would be cool if people could give a window for how long it would take for any listed career to reduce in number of jobs, or to become obsolete. Maybe that way it would be useful for people of varying ages. submitted by /u/throw1274637374 [link] [com
NASA's InSight lander has been declared dead after four years on Mars
Over the course of its time on Mars, the InSight lander measured 1319 marsquakes, but it has finally been overwhelmed with dust and its mission has come to an end
Astronomers spot stars in the most distant galaxies for the first time
Since it launched on December 25th, 2021, the James Webb Space Telescope (JWST) has taken the sharpest and most detailed images of the universe, surpassing even its predecessor, the venerable Hubble Space Telescope. But what is especially exciting are the kinds of observations we can look forward to, where the JWST will use its advanced capabilities to address some of the most pressing cosmologica
We could spread life to the Milky Way with comets. But should we?
Here's a thorny problem: What if life doesn't always appear on planets that can support it? What if we find more and more exoplanets and determine that some of them are habitable? What if we also determine that life hasn't appeared on them yet?
COVID hit companies hard. Why some kept their sustainability commitments, and others didn't
COVID-19 has had profound implications for the "role of business in society". One of them is the pandemic's effect on companies' sustainability strategies. These are efforts to avoid companies' harmful impacts on the environment and communities, and to enhance the positive impacts.
Author Correction: Stacking ensemble learning model to predict 6-month mortality in ischemic stroke patients
Scientific Reports, Published online: 21 December 2022; doi:10.1038/s41598-022-26732-8
The impact of treatment on the psychological burden of mothers of children with chronic hepatitis C virus infection: a multicenter, questionnaire survey
Scientific Reports, Published online: 21 December 2022; doi:10.1038/s41598-022-25519-1
Shoulder stretching versus shoulder muscle strength training for the prevention of baseball-related arm injuries: a randomized, active-controlled, open-label, non-inferiority study
Scientific Reports, Published online: 21 December 2022; doi:10.1038/s41598-022-26682-1
Unlimited energy from fusion became a more feasible prospect in 2022
Landmark confirmations of physics theory, including an energy production breakthrough at the end of the year, have turned fusion power stations into an engineering challenge rather than a physics one
Brain stimulation boosts hearing in rats with ear implants
Nature, Published online: 21 December 2022; doi:10.1038/d41586-022-04553-z Study identifies neurons that can improve sound perception, which could explain the variation in performance in people with cochlear devices.
WHO urges China to step up vaccinations after rise in Covid cases
Beijing asked to make more data available on disease severity, hospital admissions and occupancy rates
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