Archaeologists uncover oldest known projectile points in the Americas
Oregon State University archaeologists have uncovered projectile points in Idaho that are thousands of years older than any previously found in the Americas, helping to fill in the history of how early humans crafted and used stone weapons.
How Many Republicans Died Because the GOP Turned Against Vaccines?
On his prime-time Fox News show, Tucker Carlson has regularly questioned the safety of vaccines, inviting guests who have called for the shots to be " withdrawn from the market ." Breaking down the cost of vaccine hesitancy would be simple if we could draw a causal relationship between Republican leaders' anti-vaccine messaging and the adoption of those ideas by Americans, and then from those ideas to deaths due to non-vaccination.
El Niño Is Coming—and the World Isn't Prepared
Global heating will set the stage for extreme weather everywhere in 2023. The consequences are likely to be cataclysmic.
LATEST
Deadly winter blizzard leaves US in pre-Christmas deep freeze
A fearsome winter storm that pummelled the United States with blinding snow and powerful Arctic winds left about a million customers without power Saturday as thousands of cancelled flights stranded travelers making last-minute dashes for Christmas.
Shackleton's Ship Found After a Century-Long Search
Scientists finally located the 107-year-old shipwreck, deep within the Weddell Sea.
How Cities Choose and Relocate Those Massive Christmas Trees
Ever wonder where the huge Christmas tree at Rockefeller Plaza or other cities comes from? One person usually chooses the tree, and it takes a lot of effort to get it there.
Why Does Marijuana Cause Panic Attacks in Some People?
Several different factors can cause marijuana-induced panic attacks. How it's consumed and the amount are two main reasons.
It's Rare, But a Lioness Can Grow a Mane
A lioness at the Topeka Zoo and others at least two other zoos — as well as a handful living in the wild — have grown manes. Why?
Scientists Grow First Plants in Lunar Soil
Good news for future long-term, off-world missions.
Narcissistic Personality Disorder: Main types and brain differences
submitted by /u/SnooGuavas4889 [link] [comments]
The W boson gave particle physicists a major shock in 2022
Physicists are still puzzled by a new measurement of a fundamental particle called the W boson, which doesn't agree with our existing understanding of the universe
2022 SkS Weekly Climate Change & Global Warming News Roundup #51
sts say Arctic warming could be to blame for blasts of extreme cold by Scott Dance, Climate, Washington Post, Dec 23, 2022 Sat, Dec 24, 2022 The right-wing groups behind renewable energy misinformation by David Roberts, Volts, Dec 23, 2022 Exxon's bad reputation got in the way of its industry-wide carbon capture proposal by Nicholas Kusnetz, Inside Climate News/Ars Technica, Dec 23, 2022 NASA:
Relationship between institutional intensive care volume prior to the COVID-19 pandemic and in-hospital death in ventilated patients with severe COVID-19
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26893-6
Applying fuzzy qualitative comparative analysis to identify typical symptoms of COVID-19 infection in a primary care unit, Rio de Janeiro, Brazil
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26283-y
Geochemical signatures of sedimentary and diagenetic processes in the trace fossil Rosselia from the Pliocene in Taiwan
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26772-0
A Nightmare Face Is Haunting AI Art, And There's A Reason We Shouldn't Look Away
The future of art needn't be so terrifying.
hey guys i have just started researching Greta thunberg, and im wanting to know more about the current climate situation.
I am wanting to know which points she makes are either disputed or agreed to, from people from both sides of the conversation. I think her platform is important to our future, but i think her solutions are just not feasible, or even possible. I have watched a few documentaries about climate change, and she seems to in line with what was said in those documentaries. I would like to do my part, by
What social conventions might and will change when Gen Z takes power of the goverment?
I believe once when Gen Z or late millenials take power social norms and traditions that have been there for 100s of years will dissapear.
5,700 years of sea-level change in Micronesia hint at humans arriving much earlier than we thought
Sea levels in Micronesia rose much faster over the past 5,000 years than previously thought, according to our new study published today in Proceedings of the National Academy of Sciences.
Tony Beets' Risky Bulldozer Repairs! | Gold Rush
Stream Gold Rush on discovery+: https://www.discoveryplus.com/show/gold-rush #GoldRush #Discovery #discoveryplus Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitter.com/Discovery From: Discover
These Were the Top 10 Most-Read Singularity Hub Stories of 2022
They can contribute to lung problems like cancer and COPD, as well as heart disease and other health issues." A Spinal Cord Implant Allowed Paralyzed People to Walk in Just One Day By Shelly Fan "Michel Roccati never thought he'd walk again, much less swim, cycle, or paddle a kayak.
Synergistic effects of defocus-incorporated multiple segments and atropine in slowing the progression of myopia
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-25599-z
Planet spiralling into star may offer glimpse into Earth's end
For the first time astronomers have identified a planet that is spiralling towards a cataclysmic collision with its ageing sun, potentially offering a glimpse into how Earth could end one day.
Molecular polariton electroabsorption
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35589-4 The authors investigate whether strong light-matter coupling can alter the nonlinear optical response of molecules inside a microcavity. Focusing on electroabsorption as a model third order nonlinearity, they find that apparent discrepancies between experiment and classical transfer matrix modeling arise fro
Weekend reads: UCSF apologizes for prison research; top judge in Mexico accused of plagiarism; peer review under scrutiny
W ould you consider a donation to support Weekend Reads, and our daily work ? Thanks in advance. The week at Retraction Watch featured: That paper with the 'T' error bars was just retracted Retraction Watch grows again, thanks to a $250,000 grant from the WoodNext Foundation The top 10 retraction stories of 2022 Contamination leads to swift retraction for Science paper on the origins of Omicron i
Mystery Nevada fossil site could be ancient maternity ward
Scientists have uncovered new clues about a curious fossil site in Nevada, a graveyard for dozens of giant marine reptiles. Instead of the site of a massive die-off as suspected, it might have been an ancient maternity ward where the creatures came to give birth.
Mystery Nevada fossil site could be ancient maternity ward
Scientists have uncovered new clues about a curious fossil site in Nevada, a graveyard for dozens of giant marine reptiles. Instead of the site of a massive die-off as suspected, it might have been an ancient maternity ward where the creatures came to give birth.
Russians Hacked JFK Airport Taxi Dispatch in Line-Skipping Scheme
Plus: An offensive US hacking operation, swatters hacking Ring cameras, a Netflix password-sharing crackdown, and more.
Responses to salinity in the littoral earthworm genus Pontodrilus
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26099-w
Dietary supplement mislabelling: case study on selected slimming products by developing a green isocratic HPLC method for their quality control
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-24830-1
Highly active and stable OER electrocatalysts derived from Sr2MIrO6 for proton exchange membrane water electrolyzers
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35631-5 While water splitting offers a renewable means to produce H2 fuel, most electrolyzers rely on scarce elements to function. Here, authors study low-content Iridium catalysts derived from mixed oxides for proton exchange membrane water electrolysis anodes without compromising activity and durability.
Stranded Dolphins Show Signs of Alzheimer's Disease in Their Brains
They may have lost their way.
25 breathtaking images of the northern lights
Auroras paint the skies in eerie hues of green and blue in these stunning images of the northern lights.
Moore's Law for Everything
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Chinese scientists say they have successfully tested a method of inducing hibernation states in primates that may be useful for humans on long journeys in space
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This Christmas, It's 'Firmageddon' as Climate Change Hits Oregon
More than a million acres of state forest contain trees that have succumbed to stressors exacerbated by a multiyear drought
How Long Until Alaska's Next Oil Disaster?
Oil Cook Inlet Alaska
Photographs by Acacia Johnson Stephen Payton has spent a lot of time planning for disaster. The environmental program coordinator for the Seldovia Village Tribe in Southcentral Alaska and a board member of the Seldovia Oil Spill Response Team, he's helped organize countless drills with volunteers, preparing to respond to an oil spill in nearby Cook Inlet. Over and over, he's practiced setting out
How the French Do Christmas
My first true Christmas in France, 12 years ago, almost didn't happen. The day before flying to meet my fiancée in Paris, I'd gone to a Walgreens near my parents' house in central New Jersey to get a flu shot. Though I trust the science, and had been assured this was impossible, within 24 hours of getting jabbed I was convulsing on my mother's couch with one of the severest fevers and respiratory
New sensor uses MRI to detect light deep in the brain
Using a specialized MRI sensor, engineers have shown that they can detect light deep within tissues such as the brain.
Ron Johnson's "vaccine round table" does little to actually help patients.
Sen. Ron Johnson held a roundtable discussion earlier this month regarding COVID-19 vaccine injuries. It featured a cast of antivax grifter and typical antivax talking points that we've come to know since the pandemic hit. This antivax propaganda exercise helps no one other than the antivaccine movement. The post first appeared on Science-Based Medicine .
Why All The Colors of The Rainbow Doesn't Include Black, Brown, And Gray
Color us surprised.
TikTok's Dream Worlds Thrived in a Nightmare Year
From "shifting" into fantasy to visiting virtual taverns, the video-sharing platform offered escape from harsher realities.
Transformative Businesses Are Born in Tough Times
What with war, layoffs, and climate collapse, it's easy to be pessimistic—but downturns often breed the most enduring companies.
Eating Too Much Salt Could Cause Stress Levels to Rise
Holiday feasts tend to be salt-heavy—but early animal experiments are finding that overindulging in the condiment could take an emotional toll.
Amazon Has Conquered Christmas—but Its Reign May Be Ending
The retail giant mastered the mince pie and shoved its way into the holidays. But, it's also had to cut back on its private-label products after poor sales.
The 15 Best Movies of 2022—and Where to Watch Them
Yes, Top Gun: Maverick made the list. Yes, we're as surprised as you are.
Sacral neuromodulation for overactive bladder using the InterStim and BetterStim systems
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26267-y
Arf1 facilitates mast cell proliferation via the mTORC1 pathway
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26925-1
Impairment in novelty-promoted memory via behavioral tagging and capture before apparent memory loss in a knock-in model of Alzheimer's disease
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26113-1
A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26792-w
Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35632-4 Experimental microsurgery techniques are powerful for studying embryonic development but require highly trained operators to achieve reproducible results. Here they develop a high precision robotic micromanipulation platform to systematically perturb the physical structure of the developing zebrafish embryo,
How the Christmas tree tradition came to be
Whether as palm branches gathered in Egypt in the celebration of Ra or wreaths for the Roman feast of Saturnalia, evergreens have long served as symbols of the perseverance of life during the bleakness of winter, and the promise of the sun's return.
The Arctic and Antarctic saw record warmth and ice melt in 2022
The sea ice around Antarctica shrank to the smallest area ever recorded in early 2022, and there were exceptionally high temperatures at both poles
How do smelling salts work?
Smelling salts are found in Victorian novels to rouse fainting women and on the sports field to possibly help athletes. But how do they work?
Cre AI tives: Your Go-To Destination for AI Resources
Welcome to Cre AI tives, a comprehensive database of AI-related resources. Our goal is to make it easy for you to find and access the tools, books, courses, and other materials you need to learn about and work with artificial intelligence. Whether you're a beginner or an experienced practitioner, we hope you'll find something useful on our site. We're always adding new content, so be sure to chec
Effect of external magnetic field and doping on electronic and thermodynamic properties of planer and buckled silicene monolayer
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26353-1
Sperm morphology and performance in relation to postmating prezygotic isolation in two recently diverged passerine species
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26101-5
Overlapping states of AWGS muscle dysfunction and inverse feasibility of ADL recovery by rehabilitation in older inpatients
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26622-z
Improved β-cell function leads to improved glucose tolerance in a transgenic mouse expressing lipoprotein lipase in adipocytes
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26995-1
Functional characterization of ABCA4 genetic variants related to Stargardt disease
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26912-6
Impact of volume status on sarcopenia in non-dialysis chronic kidney disease patients
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-25135-z
American prejudice during the COVID-19 pandemic
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-26163-5
Consciousness alteration in focal epilepsy is related to loss of signal complexity and information processing
Scientific Reports, Published online: 24 December 2022; doi:10.1038/s41598-022-25861-4
Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35504-x Imaging non-repetitive loci in living cells remains challenging. Here, the authors engineered an inducible system whereby biomolecular assemblies can be guided to specific genomic loci by a nuclease-defective Cas9, allowing the simultaneous imaging and manipulation of the loci.
An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35620-8 How glial cells like astrocytes shape complex brain functions remains unclear. Here, the authors identified an astrocyte-mediated excitatory signaling loop between neurons and their own dendritic signal integration that supports spatial memory.
The 10 biggest scientific breakthroughs of 2022
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2022 gave us many reasons to be encouraged about our future
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"Electric Cars: Not Necessarily the Future of Transportation"
Ford Electric EV Tesla
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Do you smell what I smell? How scents linked to Christmas have changed
While oranges and cloves moved from medicine cabinet to kitchen, rosemary fell out of festive fashion in England The waft of pine trees and cinnamon biscuits may mean it is beginning to smell a lot like Christmas, but the odours that conjure up yuletide today may not always have had such joyful connotations, research has revealed. Experts studying records of smells described in texts dating as fa
Quantifying the role of variability in future intensification of heat extremes
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35571-0 Heat extremes have been growing at staggering rates with global warming. This study shows that temperature variability is key to explaining the highly heterogeneous trajectories of future extremes and their rapid intensification in many regions.
A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35604-8 Efferocytosis describes the engulfment and clearance of apoptotic cells by phagocytes. Here the authors identify in primary mouse macrophage WDFY3 as a regulator for efferocytosis, in which c-terminal WDFY3 is sufficient to modulate degradation while full-length WDFY3 is required to modulate the uptake of ap
Centrifugal multimaterial 3D printing of multifunctional heterogeneous objects
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35622-6 Multimaterial 3D printing using digital light processing (DLP) is challenging because multimaterial switching methods require direct contact onto the printed part to remove residual resin. Here, the authors report a DLP-based centrifugal multimaterial 3D printing method to generate large-volume heterogeneous
'Epic' winter storm wallops US, leaving 1 mn without power
More than a million US power customers were in the dark Friday as a "bomb cyclone" winter storm walloped the country, closing highways, grounding flights and causing misery for Christmas travelers.
Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen Agrobacterium tumefaciens
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35607-5 Some bacteria use the muropeptide transporter AmpG for uptake and recycling of cell wall fragments that are released during cell growth and division. Here, Gilmore & Cava show that the plant pathogen Agrobacterium tumefaciens, which lacks an AmpG homologue, uses a different type of transporter for the same f
A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine function in children with newly diagnosed type 1 diabetes
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35544-3 Based on preclinical studies, gamma aminobutyric acid (GABA) and immunization for the enzyme that produces GABA glutamate decarboxylase (GAD) could be a potential therapy for type 1 diabetes. Here the authors report that in a placebo-controlled, double blind trial in children with new onset type 1 diabetes o
Vinder af Videnskabens top-5: Dansk teknologi central i udforskningen af Mars
PLUS. Hvert år udpeger Ingeniøren årets bedste danske forskningsresultater.
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35641-3 Combining high-speed AFM, single molecule recognition force spectroscopy, and molecular dynamics simulations Zhu, Canena, Sikora et al. characterize the interaction dynamics of the trimeric spike protein of SARS-CoV-2 wt, and delta and omicron variants with its entry receptor ACE2. While delta variant increa
Country diary: Starry-eyed, watching the lights in the dark | Amy-Jane Beer
Welburn, North Yorkshire: The moon is yet to appear, but the night is vivid with something larger than life The sun has stalled. Solstice is from the Latin Sol and sistere, meaning to stand still. In December, the hiatus is around our star's southernmost rising and setting points, and appears to last about two weeks to the naked-eye observer. In the northern hemisphere, it brings us the shortest
Vind hovedpræmien på 5000,- | Hvor mange jodtabletter skal man spise for at forhindre optagelse af radioaktivt jod?
Deltag i Ingeniørens Julequiz om årets tech-historier og vind flotte præmier!
Future of Games
I've been thinking about the future of games, and how our culture recycles the format of games as technologies progress Examples: – Ancient / old board games (e.g., chess, risk) – Sports from the 19th/20th centuries (e.g., baseball, football) – Video games (e.g., fortnite) Does it really make sense for all 3 to evolve into the next tech eras? (E.g., life size chess board in VR, realistic fortnite
Topographic organization of eye-position dependent gain fields in human visual cortex
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35488-8 It is not fully understood how sensory ambiguity introduced by eye movements is resolved by the visual system. Here, the authors use an encoding model to capture gain modulation of visual responses in 7 T fMRI data.
Continuous cholinergic-dopaminergic updating in the nucleus accumbens underlies approaches to reward-predicting cues
Nature Communications, Published online: 24 December 2022; doi:10.1038/s41467-022-35601-x Nucleus accumbens cholinergic interneurons release acetylcholine and glutamate. Here, authors show that acetylcholine, rather than glutamate, is predominantly involved in updating dopamine dynamics mediating Pavlovian approach behaviours.
Jawbone Discovery Suggests Modern Mammals Originated in The Southern Hemisphere
Our origin story may have just been flipped on its head.
States are testing roads made from old plastic bags and ink cartridges
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The countries launching missions to the Moon and beyond in 2023
In 2023 several countries will launch missions to the Moon and beyond.
5 Extreme Times Tardigrades Proved Themselves to Be Incredibly Resilient
They can take it.
A Year of Botched Executions
This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here . This year, the state of Alabama botched three consecutive executions by lethal injection: One man died after three hours of apparent torture, while two others lived. "The state's incompetence," Elizab
Bird diversity increased in severely burned forests of Southern Appalachian mountains
A new study found bird diversity increased in North Carolina mountain forest areas severely burned by wildfire in 2016, reinforcing that while wildfire can pose risks to safety and property, it can be beneficial to wildlife. The study results could help forest managers better predict bird responses to wildfire, and manage forests to benefit birds.
Male gender bias deters men from some career paths
Men are less likely to seek careers in early education and some other fields traditionally associated with women because of male gender bias in those fields.
The Israeli Government Goes Extreme Right
Netanyahu Arab Israel
In 2015, an Israeli police investigation into Jewish extremism uncovered a wedding video that shocked the public. In the clip, a group of far-right revelers were captured celebrating by stabbing a picture of a Palestinian baby who had been murdered in a recent firebombing in the West Bank village of Duma, perpetrated by a settler extremist. The guests at this affair drew from the furthest reaches
Congress passes the FDA Modernization Act removing the animal testing requirement and allowing developers to use human-relevant tech. like organ chips in drug development
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All I want for Christmas is 400 GW of solar installed in 2023
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[December 2018] World's first no-kill eggs go on sale in Berlin
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Speak | Learn a Language by Speaking to an AI
Funded by OpenAi Speak.com " is creating an AI tutor that can have open-ended conversations with learners on any number of topics, providing real-time feedback on pronunciation, grammar, vocabulary, and more." submitted by /u/ECommerce_Developer [link] [comments]
Finding hidden regularities in nature: Researchers apply deep learning to X-ray diffraction
X-ray diffraction (XRD) is an essential technique to identify the structures and compositions of newly developed materials. However, XRD patterns consist of multiple peaks, and it is not always possible to judge which ones are relevant to describe the features of the material. Researchers have recently proposed a neural network that uses the auto-encoder technique to permit the in-depth analysis o
Remembering the Strange Dream of Lockdown New York
New York City in the early days of pandemic shutdowns was a horrible place to be. As fatal chaos unfolded in the hospitals, a gloriously noisy soundscape was replaced by terrifyingly constant sirens and the thrum of refrigerated morgue trucks. Anyone on the sidewalk, many of them essential workers who had no choice but to be there, moved away from other passersby in a fearful overshoot of the rec
Glassfrogs achieve transparency by packing red blood cells into mirror-coated liver
Glass Red Blood Cells
New research shows that glassfrogs — known for their highly transparent undersides and muscles — perform their 'disappearing acts' by stowing away nearly all of their red blood cells into their uniquely reflective livers. The work could lead to new avenues of research tied to blood clots, which the frogs somehow avoid while packing and unpacking about 90 percent of their red blood cells into the
Found! Lost puzzle piece involved in gene regulation revealed in search that began in water-loving, one-celled organism
After an intrepid, decade-long search, scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome — a rare genetic, neurocognitive disorder.
Evidence of horizontal gene transfer between human maternal microbiome and infant gut microbiome
Researchers have discovered a new mode of vertical mother-to-infant microbiome transmission, where microbes in the maternal gut shared genes with microbes in the infant gut during the perinatal period starting immediately before birth and extending thought the first few weeks after birth. This horizontal gene transfer allowed maternal microbial strains to influence the functional capacity of the i
Scientists identify neural circuit that enables self-localization in zebrafish
A multiregional brain circuit allows larval zebrafish to track where they are, where they've been, and how to get back to their original location after being displaced, researchers report. The results shed light on how vertebrates track their displacements to later return to previous locations.
Researchers use 3D bioprinting to create eye tissue
NIH Bioprinting Eye Tissue
Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team printed a combination of cells that form the outer blood-retina barrier–eye tissue that supports the retina's light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study de
MALAT1 modulates alternative splicing by cooperating with the splicing factors PTBP1 and PSF | Science Advances
Abstract Understanding how long noncoding RNAs (lncRNAs) cooperate with splicing factors (SFs) in alternative splicing (AS) control is fundamental to human biology and disease. We show that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a well-documented AS-implicated lncRNA, regulates AS via two SFs, polypyrimidine tract–binding protein 1 (PTBP1) and PTB-associated SF (PSF). MA
The transcription factor Zic4 promotes tentacle formation and prevents epithelial transdifferentiation in Hydra | Science Advances
Abstract The molecular mechanisms that maintain cellular identities and prevent dedifferentiation or transdifferentiation remain mysterious. However, both processes are transiently used during animal regeneration. Therefore, organisms that regenerate their organs, appendages, or even their whole body offer a fruitful paradigm to investigate the regulation of cell fate stability. Here, we used Hyd
Ionic-electronic halide perovskite memdiodes enabling neuromorphic computing with a second-order complexity | Science Advances
Abstract With increasing computing demands, serial processing in von Neumann architectures built with zeroth-order complexity digital circuits is saturating in computational capacity and power, entailing research into alternative paradigms. Brain-inspired systems built with memristors are attractive owing to their large parallelism, low energy consumption, and high error tolerance. However, most
Prostaglandin EP3 receptor–expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling | Science Advances
Abstract The bidirectional controller of the thermoregulatory center in the preoptic area (POA) is unknown. Using rats, here, we identify prostaglandin EP3 receptor–expressing POA neurons (POA EP3R neurons) as a pivotal bidirectional controller in the central thermoregulatory mechanism. POA EP3R neurons are activated in response to elevated ambient temperature but inhibited by prostaglandin E 2 ,
Freestanding epitaxial SrTiO3 nanomembranes via remote epitaxy using hybrid molecular beam epitaxy | Science Advances
Abstract The epitaxial growth of functional oxides using a substrate with a graphene layer is a highly desirable method for improving structural quality and obtaining freestanding epitaxial nanomembranes for scientific study, applications, and economical reuse of substrates. However, the aggressive oxidizing conditions typically used in growing epitaxial oxides can damage graphene. Here, we demon
Regulation of eIF4E guides a unique translational program to control erythroid maturation | Science Advances
Abstract Translation control is essential in balancing hematopoietic precursors and differentiation; however, the mechanisms underlying this program are poorly understood. We found that the activity of the major cap-binding protein eIF4E is unexpectedly regulated in a dynamic manner throughout erythropoiesis that is uncoupled from global protein synthesis rates. Moreover, eIF4E activity directs e
Symbiotic microbes aid host adaptation by metabolizing a deterrent host pine carbohydrate d-pinitol in a beetle-fungus invasive complex | Science Advances
Abstract The red turpentine beetle (RTB) is one of the most destructive invasive pests in China and solely consumes pine phloem containing high amounts of d -pinitol. Previous studies reported that d -pinitol exhibits deterrent effects on insects. However, it remains unknown how insects overcome d -pinitol during their host plant adaptation. We found that d -pinitol had an antagonistic effect on
Circulating hemopexin modulates anthracycline cardiac toxicity in patients and in mice | Science Advances
Abstract Anthracyclines such as doxorubicin (Dox) are effective chemotherapies, but their use is limited by cardiac toxicity. We hypothesized that plasma proteomics in women with breast cancer could identify new mechanisms of anthracycline cardiac toxicity. We measured changes in 1317 proteins in anthracycline-treated patients ( n = 30) and replicated key findings in a second cohort ( n = 31). An
Manganese-coordinated mRNA vaccines with enhanced mRNA expression and immunogenicity induce robust immune responses against SARS-CoV-2 variants | Science Advances
Abstract It is urgent to develop more effective mRNA vaccines against the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants owing to the immune escape. Here, we constructed a novel mRNA delivery system [IC8/Mn lipid nanoparticles (IC8/Mn LNPs)]with high immunogenicity, via introducing a stimulator of interferon genes (STING) agonist [manganese (Mn)] based on a newly s
ACTR5 controls CDKN2A and tumor progression in an INO80-independent manner | Science Advances
Abstract Epigenetic dysregulation of cell cycle is a hallmark of tumorigenesis in multiple cancers, including hepatocellular carcinoma (HCC). Nonetheless, the epigenetic mechanisms underlying the aberrant cell cycle signaling and therapeutic response remain unclear. Here, we used an epigenetics-focused CRISPR interference screen and identified ACTR5 (actin-related protein 5), a component of the I
An orbitofrontal cortex–anterior insular cortex circuit gates compulsive cocaine use | Science Advances
Abstract Compulsive drug use, a cardinal symptom of drug addiction, is characterized by persistent substance use despite adverse consequences. However, little is known about the neural circuit mechanisms behind this behavior. Using a footshock-punished cocaine self-administration procedure, we found individual variability of rats in the process of drug addiction, and rats with compulsive cocaine
Exposure to gun violence among the population of Chicago community violence interventionists | Science Advances
Abstract Gun violence is a leading cause of premature death and a driver of racial disparities in life expectancy in the United States. Community-based interventions are the foremost policy strategy for reducing gun violence without exacerbating harm associated with criminal justice approaches. However, little is known about the interventionist workforce. In 2021, we used a researcher-guided surv
Researchers use 3D bioprinting to create eye tissue
NIH Bioprinting Eye Tissue
Scientists used patient stem cells and 3D bioprinting to produce eye tissue that will advance understanding of the mechanisms of blinding diseases. The research team printed a combination of cells that form the outer blood-retina barrier–eye tissue that supports the retina's light-sensing photoreceptors. The technique provides a theoretically unlimited supply of patient-derived tissue to study de
Overshooting climate targets could significantly increase risk for tipping cascades
Temporarily overshooting the climate targets of 1.5-2 degrees Celsius could increase the tipping risk of several Earth system elements by more than 70 percent compared to keeping global warming in line with the United Nations Paris Agreement range, a new risk analysis study by an international team of researchers shows. This tipping risk increases even if in the longer term the global temperature
Hunter-gatherer social ties spread pottery-making far and wide
Analysis of more than 1,200 vessels from hunter-gatherer sites has shown that pottery-making techniques spread vast distances over a short period of time through social traditions being passed on.
Scientists find the earliest evidence of a dinosaur eating a mammal
Birdlike dinosaur "was not a picky eater," as evidenced by a rodent's foot found in its fossilized remains.
Penalties, corruption and legislation are failing to deter harmful gas flaring in Nigeria, study shows
Legislation is failing to end gas flaring in Nigeria which is harming and environment and people's health, a new study warns.
Software lets researchers create tiny rounded objects out of DNA. Here's why that's cool
Marvel at the tiny nanoscale structures emerging from research labs at Duke University and Arizona State University, and it's easy to imagine you're browsing a catalog of the world's smallest pottery.
Electrons on the run: On chirality, tunneling and light fields
Will an electron escaping a molecule through a quantum tunnel behave differently depending on the left- or right-handedness of the molecule?
Association of plasma cystatin C with all-cause and cause-specific mortality among middle-aged and elderly individuals: a prospective community-based cohort study
Scientific Reports, Published online: 23 December 2022; doi:10.1038/s41598-022-24722-4
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