Artemis: Nasa expects humans to live on Moon this decade
7hA senior official tells the BBC the Artemis missions will lead to astronauts living on the Moon.
NASA Moon mission 'exceeding' expectations
11hOn the third day after lifting off from Florida bound for the Moon, the Orion spacecraft is "exceeding performance expectations," NASA officials said on Friday.
Elizabeth Holmes of Theranos Gets 11 Years in Prison
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1dHolmes Theranos Years
The former Theranos CEO's fall is a cautionary tale for eccentric founders and the investors who blindly throw money at their inventions.
LATEST
COP27: UN climate talks go into the night amid tense negotiations
nowRepresentatives at COP27 in Egypt have been locked in negotiations for far longer than expected.
Meet the host of NASA's first Spanish-language podcast
54minNPR's Michel Martin speaks with Noelia González, the host of Universo Curioso de la NASA .
Ode to Not Watching the World Cup
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1hKarasev the World Cup
I don't want to overstate this. I don't want to say that by watching World Cup 2022, held in Qatar, on your personal entertainment device, you're stepping over the bodies of dead migrant workers, standing on the heads of incarcerated queer people, and bankrolling, in a tiny but critical way, the global grift. Because we're all compromised, right? We're all implicated. We all live in webs of capit
Artemis: Nasa expects humans to live on Moon this decade
1hsubmitted by /u/nastratin [link] [comments]
2022 SkS Weekly Climate Change & Global Warming News Roundup #47
1hA chronological listing of news articles posted on the Skeptical Science Facebook Page during the past week: Sun, Nov 13, 2022 thru Sat, Nov 19, 2022. Story of the Week Is COP27 the End of Hopes for Limiting Global Warming to 1.5 Degrees Celsius? The climate talks are going into overtime with little progress toward the emissions cuts required to meet the goals of the Paris Agreement. The COP27 cl
Sam Bankman-Fried Is Going Down Posting
1hAfter losing more than $1 billion of his customers' money, the disgraced crypto titan Sam Bankman-Fried had just one thing to say. "1) What." That inscrutable message, posted on Twitter last weekend, followed a cataclysmic week for the 30-year-old. FTX, the cryptocurrency-trading site he'd founded and turned into a global behemoth, went insolvent. Bankman-Fried's personal wealth plummeted from $1
Scientists Just Spotted This Large, Colorful Pigeon That No One Has Seen in 140 Years
2hIt was like "finding a unicorn".
The world generates so much data that new unit measurements were created to keep up
2hThe mass of the Earth can now be measured as 6 ronnagrams rather than 6,000 yottagrams. An electron's mass can now be said to be about 1 rontogram rather than 0.001 yoctograms. (Image credit: Chris Hondros/Getty Images)
Fireball Flashes Above Ontario and Parts of the U.S.
3hThe bright meteor was the sixth object detected in space before striking Earth, the European Space Agency said.
So Many People Are Using a Diabetes Drug for Weight Loss That Actual Diabetics Are Having Trouble Getting It
3hAt this point, it's likely that Ozempic has somehow come into your personal zeitgeist. The expensive, name-brand version of semaglutide — which, importantly, was originally developed to manage type 2 diabetes — has been in high demand after going viral on TikTok, where it's picking up a reputation as an effective weight loss aid. "It's the most common medication that I get asked about," Dr. Sudee
Antigenic sin of wild-type SARS-CoV-2 vaccine shapes poor cross-neutralization of BA.4/5/2.75 subvariants in BA.2 breakthrough infections
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3hOmicron BA.2 Delta
Nature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34400-8 Updated vaccines based on Omicron subvariants have started to being rolled out. Analysis of antibody response in individuals with two or three vaccine doses suggests that BA.2 breakthrough infection barely increases cross-neutralization capacity against BA.4/5 or BA.2.75.
It's Official: The Leap Second Will Be Retired (a Decade from Now)
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4hLeap Seconds 2035 Time
On Friday, an international vote was taken to ditch the leap second, a technical fudge that has caused headaches since its inception 50 years ago.
Wave induced coastal flooding along the southwest coast of India during tropical cyclone Tauktae
4hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-24557-z
Tube length of chironomid larvae as an indicator for dissolved oxygen in water bodies
4hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-23953-9
Gennembrud på klimatopmøde: Klimaudsatte ser ud til at få en katastrofefond
4hTidligere i dag lignede klimatopmødet i Egypten et "flop-COP", men landene nærmer sig nu en aftale.
Amazing Map Lets You Scroll Through the Entire Known Universe
5hAll-Encompassing The universe is so vast and old that we can't possibly fathom it all. But we can make some pretty admirable efforts. Take this stunning new map , put together by astronomers at Johns Hopkins University, that displays the entire known universe in all its glory, showcasing some 200,000 galaxies as tiny dots that span all the way to the cosmos' observable limits. Using data gathered
How people wake up is associated with previous night's sleep together with physical activity and food intake
5hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34503-2 In a prospective longitudinal study of 833 adults, we demonstrate that how you wake up and regain alertness in the hours after sleep is weakly associated with your genes. Instead, the modifiable factors of how you are sleeping, eating and exercising influence your return to full alertness, free of sleepiness
Workplace brain scanning to make employees happier and more productive
5hsubmitted by /u/BotJunkie [link] [comments]
The road to low-carbon concrete: Humanity's love affair with cement and concrete results in massive CO2 emissions.
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5hArago Cement China
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Researchers say they are close to reversing aging (in humans). Dr David Sinclair says treatments to actually reverse human aging in the elderly will be available "in ten to fifteen years".
5hsubmitted by /u/izumi3682 [link] [comments]
Can Aging Be Reversed? Scientists Are On The Verge Of Turning It Into A Reality
5hsubmitted by /u/izumi3682 [link] [comments]
A Scary Future of Reading People's Thoughts using Technology
5hWill all your Secrets get Exposed with Mind Reading Technology? Humans have been pondering the possibility of reading minds for a long time.But will it actually be possible in the future? Will mind-reading technology bring an end to our privacy once and for all? let's take a look Check out this video to get an overview👇 https://youtu.be/j8RGm7VK_lw Whenever we think something, there is electrica
5h
Behind the Lawsuit Against Celebs Who Shilled FTX Before Its Spectacular Meltdown
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6hSam FTX Bankman-Fried
Above all else, FTX advertisements wanted you to know two things: that cryptocurrency is a force for good, and that you don't need to be an expert to buy and trade it. In fact, you don't even have to understand it at all. You just need to get involved, because if you don't, you'll get left behind. If a bit cheesy then, those same promotions — an array of of television commercials, social media po
In a Reversal, the U.S. Agrees to Climate Payments for Poor Nations
6hA U.S. official said negotiations continue over details for a fund to help developing countries cope with "loss and damage" caused by global warming.
Experts Excoriate NASA Report Claiming James Webb Wasn't Homophobic
7hNASA says it can't find any record that James Webb, the State Department and NASA leader for whom the agency's groundbreaking new space telescope is named, was aware of homophobic government purges — but a bunch of astronomers are clapping back at the agency's claims. "After an exhaustive search of U.S. government and Truman library archives," administrator Bill Nelson was quoted as saying in the
Association between serum calcium level and in-hospital mortality in patients with acute myocardial infarction: a retrospective cohort study
7hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-24566-y
Breakthrough Machine Learning AI Runs Nuclear Fusion Reactor | New AI Supercomputer With 13.5+ Million Processor Cores | New Brain Model For Conscious AI
7hsubmitted by /u/kenickh [link] [comments]
Psychologists demonstrate why feeling appreciated is particularly important for avoidantly attached individuals
7hsubmitted by /u/Historical-Object374 [link] [comments]
Photocatalytic direct borylation of carboxylic acids
7hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34833-1 Boronic acids are useful reagents in organic synthesis and thus methods to prepare these compounds under mild conditions are desirable. Here, the authors synthesize boronic acids via photocatalytic decarboxylation of benzoic acids followed by borylation; guanidine-type additives are used to assist the proces
PEAR1 regulates expansion of activated fibroblasts and deposition of extracellular matrix in pulmonary fibrosis
7hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34870-w Currently, there is a lack of effective drugs for the treatment of pulmonary fibrosis. Here, the authors reveal a novel role of PEAR1 in fibroblast activation and demonstrate that activating PEAR1 by monoclonal antibodies might be a promising therapeutic approach for pulmonary fibrosis.
Structure of the human heparan sulfate polymerase complex EXT1-EXT2
7hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34882-6 Heparan sulfates are long and complex polysaccharides that mediate a large number of biological processes at the cell surface. Here, the authors provide structural and functional insights into the human EXT1-EXT2 complex that carries out the polymerization of heparan sulfate chains.
Amazfit Bip 3 Pro review
7hThe Amazfit Bip 3 Pro is a great budget fitness tracker, but it won't have Apple or Fitbit panicking.
This MSCHF Puzzle—and the Chance of $2 Million—Brought My Family Closer
7hEvery MSCHF puzzle offers a potential cash prize for players. It's infuriating—and 100 percent worth it.
8h
This Week's Awesome Tech Stories From Around the Web (Through November 19)
8hFUTURE Picture Limitless Creativity at Your Fingertips Kevin Kelly | Wired "For the first time in history, humans can conjure up everyday acts of creativity on demand, in real time, at scale, for cheap. Synthetic creativity is a commodity now. Ancient philosophers will turn in their graves, but it turns out that to make creativity—to generate something new—all you need is the right code. We can i
$500K Haul for Parker! A Season's Worth of Gold in a Week! | Gold Rush
8hStream Gold Rush on discovery+: https://www.discoveryplus.com/show/gold-rush #GoldRush #Discovery #discoveryplus Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitter.com/Discovery From: Discover
Earliest proof of cooking shows our ancestors liked well-done fish
8hEarly human ancestors living 780,000 years ago liked their fish well-done, Israeli researchers revealed Monday, in what they said was the earliest evidence of fire being used to cook.
Earliest proof of cooking shows our ancestors liked well-done fish
8hEarly human ancestors living 780,000 years ago liked their fish well-done, Israeli researchers revealed Monday, in what they said was the earliest evidence of fire being used to cook.
Whose Midlife Crisis Is It, Anyway?
8hThe television series Fleishman Is in Trouble begins upside down, with the camera soaring over an inverted Manhattan skyline—squat brick buildings in the top half of the frame, hazy blue sky below. It's an appropriately destabilizing introduction for a show that's constantly pulling the rug out from underneath us. The series is untrustworthy, in the best kind of way: It withholds and obscures and
Why We Eat Together
8hThis is an edition of The Wonder Reader, a newsletter in which our editors recommend a set of stories to spark your curiosity and fill you with delight. Sign up here to get it every Saturday morning. For human beings, a meal is never just a meal, and a snack is never just a snack. As the writer and scientist Louise O. Fresco noted in The Atlantic in 2015, "Even where a lonely diner picks sweets o
Tár Has an Answer to Art's Toughest Question
8hThis story contains major spoilers for Tár . As someone who writes about art and artists for a living, I confess that I find no question more exhausting than "Can we separate the art from the artist?" The only good answer is a frustrating one: "It depends." So I went into Tár , Todd Field's acclaimed movie starring Cate Blanchett, with some dread. The film, which follows a fictional famed classic
The Qatar World Cup Exposes Soccer's Shame
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8hQatar World Cup Soccer
Qatar hosting the soccer World Cup is like Donald Trump becoming president of the United States. It should not have happened, but the very fact that it has only exposes how bad things have become. Once this famous old tournament kicks off in Doha tomorrow, the fact that it did can never be unwound: Qatar will forever have been the host of the 22nd FIFA World Cup, the greatest absurdity in the his
What if You Could Go to the Hospital … at Home?
8hHospital-at-home care is an increasingly common option, and it is often a safer one for older adults. But the future of the approach depends on federal action.
How Carvedilol activates β2-adrenoceptors
8hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34765-w How carvedilol, a β1-blocker, activates β2-adrenoceptors, is unclear. Here, the authors resolve this enigma and show that carvedilol drives all of its detectable cellular β2-adrenoceptor signals by slow and low efficacy G protein activation.
It's Time to Make 3D TVs a Thing Again
8hIt's a long shot, but hear us out: The stars are beginning to align for the much-maligned technology.
A Destabilizing Hack-and-Leak Operation Hits Moldova
8hPlus: Google's location snooping ends in a $391 million settlement, Russian code sneaks into US government apps, and the World Cup apps set off alarms.
The Prius Gets a Redesign That Actually Looks Cool
8hPlus: You can now play games in Microsoft Teams, Leica debuts a new smartphone, and Netflix closes the net on account sharing.
Men's World Cup Soccer Ball, the Al Rihla, Has the Aerodynamics of a Champion
9hThe Al Rihla may fly more quickly through the air than previous World Cup balls
Ultrafast switching in synthetic antiferromagnet with bilayer rare-earth transition-metal ferrimagnets
9hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-24234-1
1904: Landvinding skal give plads til betydelig udvidelse af Aarhus Havn
9hDen voksende trafik med petroleum, naphta, benzin og deslige gør det ønskeligt at have et særligt bassin dertil, så at den egentlige havn befries for for den derfra hidrørende brandfare, skrev Ingeniøren i 1904. Den samlede anlægssum var på 12,2 millioner kroner.
The Marine Lab in the Path of Climate Change's Fury?
10hThe DeFelice Marine Center sits on a strip of land that dangles into a bay. Staff is living, working, and adapting to the climate crisis in real time.
How to Pair Joy-Cons to Your iPhone or iPad
10hThe small Nintendo Switch controller now connects to Apple's smartphones and tablets for even more gaming options.
Experts Grow New 3D-Printed Nose On Woman's Arm After She Lost Hers To Cancer
10hsubmitted by /u/Several_Cabinet_9725 [link] [comments]
Bruce Springsteen's Misguided Homage
10hWhat is it about reaching their 70s that makes great songwriters want to sing old songs they didn't write? Paul McCartney reached backwards to pre-Beatles music and released an album of mostly Tin Pan Alley ditties, slipping in a couple of originals in the same style, in 2012, the year he turned 70. Bob Dylan took up crooning vintage standards associated with Frank Sinatra for the first of severa
Radio Atlantic: For Love of the Game
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10hFrance Qatar World Cup
Part of the appeal of the World Cup is watching countries' finest soccer players represent their nations. For many fans, though, it doesn't have to just be root-root-root for the home team. The Atlantic staff writer Clint Smith will be cheering for the U.S., but he will also have his eye on Senegal. Smith's attachment to the game is personal, stretching back to when he first started soccer playin
Charge-separation driven mechanism via acylium ion intermediate migration during catalytic carbonylation in mordenite zeolite
10hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34708-5 The tremendous application of carbonylation reaction requires the elaborate explanation to reaction mechanism. Here the authors propose a charge-separation driven mechanism of methyl acetate formation via acylium ion intermediate in mordenite zeolite by an integrated reaction/diffusion kinetics model during
Avoiding Twitter? Try These Interest-Based Discord Servers
10hFrom generative AI to outer space, here's how to find a community on the social platform that discusses topics you actually find engaging.
The Lunya Silk Pajamas Are Great for Sweaty Sleepers
10hIf you also struggle to find the balance between toastiness and coziness, this set is cool, comfortable, and really, really cute.
Weekend reads: 'Illegal practices in palaeontology'; 'a fake badge of integrity'; researcher jailed
11hWould you consider a donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured: Our list of retracted or withdrawn COVID-19 papers is up to 270. There are more than 36,000 retractions in our database — which powers retraction alerts in EndNote, LibKey, Papers, and Zotero. And have you seen our leaderboard of authors with the most … Continue rea
Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5α autoubiquitylation
11hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34920-3 TRIM5α is an E3 ligase that inhibits retroviral replication. Here, the authors delineate the biochemical mechanism that accelerates N terminal autoubiquitylation of TRIM5α upon its association with the retroviral capsid and, thus, enables recognition of an infection-associated molecular pattern.
Australia aims to host 2026 UN climate summit
11hAustralia hopes to host the 2026 COP summit, Prime Minister Anthony Albanese said Saturday, seeking to overhaul his country's reputation for foot-dragging on climate change.
Despair, lack of progress at climate talks, yet hope blooms
11hIt's a desert, where little grows. It's a climate conference, where water is scarce inside buildings and out, lines are long, tempers are short, meetings go late and above all progress comes in one-drop drips.
Leak at Pennsylvania gas storage well spewing methane
11hA vent at an underground natural gas storage well in Western Pennsylvania has been spewing massive amounts of planet-warming methane into the atmosphere for more than 11 days and attempts to plug the leak have thus far failed.
Bird flu detected in southeast Alaska black bear cub
11hA black bear cub in southeast Alaska was euthanized after it became ill with avian influenza, the Alaska Department of Fish and Game said.
Does exposure to cold and flu viruses weaken or strengthen the immune system?
11hAnd is that answer different now in our Covid world? Linda Geddes looks at the evidence and talks to the experts As temperatures drop and November rain falls, the seasonal onslaught of coughs, sore throats and sniffles may feel inevitable, but does constant exposure to everyday infections such as colds or influenza drain us or make us stronger? Our immune systems are often said to have memory, me
Bird flu detected in southeast Alaska black bear cub
12hA black bear cub in southeast Alaska was euthanized after it became ill with avian influenza, the Alaska Department of Fish and Game said.
Evolution and morphology of a contourite depositional system based on new evidence from 3D-seismic data offshore Madagascar (Paleogene, Morondava Basin)
12hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-24573-z
Relaxation electrodynamics of superinsulators
12hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-24460-7
A fluorescent photoimmunoconjugate for imaging of cholesteatoma
12hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-22072-9
Lassa antiviral LHF-535 protects guinea pigs from lethal challenge
12hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-23760-2
Fracture fragment of the condyle determines the ramus height of the mandible in children with intracapsular condylar fractures treated conservatively
12hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-24463-4
High speed photo-mediated ultrasound therapy integrated with OCTA
12hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-23188-8
Ultrasound-assisted synthesis of kojic acid-1,2,3-triazole based dihydropyrano[3,2-b]pyran derivatives using Fe3O4@CQD@CuI as a novel nanomagnetic catalyst
12hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-24089-6 Ultrasound-assisted synthesis of kojic acid-1,2,3-triazole based dihydropyrano[3,2- b ]pyran derivatives using Fe 3 O 4 @CQD@CuI as a novel nanomagnetic catalyst
Gut microbiota analysis for prediction of clinical relapse in Crohn's disease
12hScientific Reports, Published online: 19 November 2022; doi:10.1038/s41598-022-23757-x
What if You Could Go to the Hospital … at Home?
12hHospital-at-home care is an increasingly common option, and it is often a safer one for older adults. But the future of the approach depends on federal action.
Klimaforhandlinger på sammenbruddets rand: EU truer med at gå
14hVi vil hellere have ingen aftale end en dårlig aftale, lyder det fra EU's klimachef, Frans Timmermans.
The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells
14hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34911-4 DNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic domain of POLE1.
Melting of generalized Wigner crystals in transition metal dichalcogenide heterobilayer Moiré systems
14hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34683-x Recent experiments on a WSe2/WS2 hetero-bilayer detected incompressible charge ordered states considered to be generalized Wigner crystals. Here, by performing Monte Carlo simulations of a triangular moiré lattice, the authors study the phases which emerge on melting such charge-ordered states in partially f
Maskinbygger kæmper for at lege med de store spillere
14hPLUS. Sønderjysk maskinbygger kan øge produktionen af flowplader til elektrolyse med en faktor 10-20. Men de store spillere er ikke nemme at få kontakt med.
'I'm afraid to have children': fear of an older future in Japan and South Korea
14hsubmitted by /u/Vucea [link] [comments]
Disparate impacts on online information access during the Covid-19 pandemic
15hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34592-z The COVID-19 pandemic has stimulated an important changes in online information access. Here, the authors analyse everyday web search interactions across 25,150 US ZIP codes revealing significant differences in how digital informational resources are mobilized by different communities.
Continuous resin refilling and hydrogen bond synergistically assisted 3D structural color printing
15hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34866-6 3D photonic crystals (PCs) attract attention due to their unique optical properties but printing of colloidal particles is limited by lack of control over the assembly. Here, the authors demonstrate a continuous digital light processing 3D printing strategy using hydrogen bond assisted colloidal inks for fab
Imperceptible, designable, and scalable braided electronic cord
15hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34918-x Inspired by the characteristics of textile-based flexible electronic sensors, the authors report a braided electronic cord with a low-cost, and automated fabrication to realize imperceptible, designable, and scalable user interfaces with the features of user-friendliness, excellent durability and rich intera
Regioselective Ni-Catalyzed reductive alkylsilylation of acrylonitrile with unactivated alkyl bromides and chlorosilanes
15hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34901-6 Synthetic methodologies that enable the formation of C‒Si bonds in organic molecules are desirable. Here, the authors report the nickel-catalyzed reductive alkylsilylation of acrylonitrile with unactivated alkyl bromides and chlorosilanes.
Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling
15hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34885-3 By recognizing double-stranded RNA, RIG-I is implicated in anti-viral immune responses, but also in cancer development and intestinal inflammation. Here the authors identify frameshift germline mutations of RIG-I, resulting in the generation of a circular RNA associated with increased susceptibility to colit
Onboard early detection and mitigation of lithium plating in fast-charging batteries
15hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-33486-4 Fast-charging is highly desired for lithium-ion batteries but is hindered by potential hazardous lithium plating and the associated parasitic reactions. Here, the authors report a nondestructive differential pressure sensing method for early detection and mitigation of lithium plating in fast-charging batter
Fra mose til landbrug og tilbage til mose: Over tusind hektar sønderjysk jord oversvømmes
15hFrem mod 2027 skal 100.000 hektar landbrugsjord tilbage til deres oprindelige, våde tilstand.
Ronnametres and quettagrams have joined the ranks of SI units
16hNew prefixes in the International System of Units have been confirmed, ushering in ronto and quecto for tiny numbers and ronna and quetta for very large numbers, like the amount of data on internet servers
Feedback between mechanosensitive signaling and active forces governs endothelial junction integrity
16hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34701-y Gap formation in the vasculature underpins immune and tumour cell infiltration. Here the authors propose a chemo-mechanical model to analyse how feedback between mechanosensitive signalling, active cellular forces and adhesion governs the breakdown, recovery, and integrity of endothelial junctions.
PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation
16hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34766-9 Mutations in PPARγ lead to lipodystrophy, but the mechanisms by which the mutations affect the activity in chromatin is unknown. Here, Madsen, Broekema et al. showed that mutations affecting two intermolecular interactions compromise chromatin remodeling.
Physics-informed deep learning approach for modeling crustal deformation
17hNature Communications, Published online: 19 November 2022; doi:10.1038/s41467-022-34922-1 Modeling crustal deformation is critical for understanding of tectonic processes and earthquake potentials. Here, the authors propose a deep learning approach that can be extended in a straightforward manner to complex crustal structures and inverse problems.
Vicky Phelan, cervical cancer campaigner, 1974 — 2022
17hShe demanded action after exposing one of the most shocking medical scandals in Ireland's history
Times are grim for both the chicken and the egg
17hThe avian flu outbreak is not the only thing to blame for the current egg shortage
18h
Skolverket: "Vi har stor tilltro till att personalen gör bra bedömningar"
18hVärldshälsoorganisationen rekommenderar att barn ska börja använda skärmar som tidigast vid 18 månaders ålder. I den svenska läroplanen för förskolan står det att varje barn, inklusive barn som är under 18 månader, ska använda digitala verktyg.
Ny forskning: Surfplattor minskar kreativiteten på förskolan
18hDigitala verktyg ingår i läroplanen för förskolebarn, redan från ett års ålder. Nu visar svensk forskning att småbarnens lek med surfplattor ser helt annorlunda ut än annan lek.
The fertility rate is dropping in many countries. The tech giants are concerned about the "population collapse" as they deem it the end of civilization. But, these tech giants want to perpetuate their lineage by having more kids, and the pronatalism phenomenon is rising in the Silicon Valley
18hsubmitted by /u/Guylikeshismovies [link] [comments]
21h
Toxins force construction of 'roads to nowhere'
21hToxins released by a type of bacteria that cause diarrheal disease hijack cell processes and force important proteins to assemble into 'roads to nowhere,' redirecting the proteins away from other jobs that are key to proper cell function, a new study has found.
Artificial neural networks learn better when they spend time not learning at all
21hResearchers discuss how mimicking sleep patterns of the human brain in artificial neural networks may help mitigate the threat of catastrophic forgetting in the latter, boosting their utility across a spectrum of research interests.
Rapid fluctuations in oxygen levels coincided with Earth's first mass extinction
21hRapid changes in marine oxygen levels may have played a significant role in driving Earth's first mass extinction, according to a new study.
New insights into energy loss open doors for one up-and-coming solar tech
21hA new method for describing energy loss in organic solar cells has paved the way for building better and more efficient devices.
Artificial neural networks learn better when they spend time not learning at all
22hResearchers discuss how mimicking sleep patterns of the human brain in artificial neural networks may help mitigate the threat of catastrophic forgetting in the latter, boosting their utility across a spectrum of research interests.
Author Correction: 3D measurement techniques for the hindfoot alignment angle from weight-bearing CT in a clinical population
22hScientific Reports, Published online: 18 November 2022; doi:10.1038/s41598-022-24322-2
Author Correction: Influence of Huangqin Decoction on the immune function and fecal microbiome of chicks after experimental infection with Escherichia coli O78
22hScientific Reports, Published online: 18 November 2022; doi:10.1038/s41598-022-24320-4
"Polytherapeutic" tinnitus treatment app delivers impressive results
23hsubmitted by /u/blaspheminCapn [link] [comments]
US can reach 100% clean power by 2035, DOE finds, but tough reliability and land use questions lie ahead
23hsubmitted by /u/nastratin [link] [comments]
Meta has withdrawn its Galactica AI, only 3 days after its release, following intense criticism. Meta's misstep—and its hubris—show once again that Big Tech has a blind spot about the severe limitations of large language models in AI.
23hsubmitted by /u/lughnasadh [link] [comments]
Adding fluoride to water supplies may deliver a modest benefit to children's dental health, finds an NIHR-funded study. | Researchers found it is likely to be a cost effective way to lower the annual £1.7billion the NHS spends on dental caries.
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'Full-on robot writing': the artificial intelligence challenge facing universities | Australian universities
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The Harvard Business School Professor Who Isn't Counting Elon Musk Out
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23hElon Musk One Twitter
In the weeks since Elon Musk took over as CEO of Twitter, the company has laid off nearly half of its workers and offered the remaining employees an ultimatum: Commit to being "extremely hardcore" going forward or leave the company . According to The New York Times , hundreds of employees have opted for the latter. On Wednesday night—as the deadline loomed—Andy Wu, an assistant professor of busin
Democracy's Dunkirk
23hThis is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here . The authoritarians at home and abroad have faced some reversals, but Americans should consider the midterm elections as only a respite. Liberal democracy remains in danger in the United States and aro
6 Years Later, Marine Life Still Hasn't Recovered From The Monstrous Ocean Heat Blob
1dThere's a new normal on the reef.
Toxins force construction of 'roads to nowhere'
1dToxins released by a type of bacteria that cause diarrheal disease hijack cell processes and force important proteins to assemble into "roads to nowhere," redirecting the proteins away from other jobs that are key to proper cell function, a new study has found.
Rapid fluctuations in oxygen levels coincided with Earth's first mass extinction
1dRapid changes in marine oxygen levels may have played a significant role in driving Earth's first mass extinction, according to a new study led by Florida State University researchers.
Artificial neural networks learn better when they spend time not learning at all
1dDepending on age, humans need 7 to 13 hours of sleep per 24 hours. During this time, a lot happens: Heart rate, breathing and metabolism ebb and flow; hormone levels adjust; the body relaxes. Not so much in the brain.
The tilt in our stars: The shape of the Milky Way's halo of stars is realized
1dA new study has revealed the true shape of the diffuse cloud of stars surrounding the disk of our galaxy. For decades, astronomers have thought that this cloud of stars—called the stellar halo—was largely spherical, like a beach ball. Now a new model based on modern observations shows the stellar halo is oblong and tilted, much like a football that has just been kicked.
NASA Will Not Change the James Webb Telescope's Name
1dThe moniker, which honors a former agency administrator accused of enforcing anti-LGBTQ policies, has long been controversial.
Toxins force construction of 'roads to nowhere'
1dToxins released by a type of bacteria that cause diarrheal disease hijack cell processes and force important proteins to assemble into "roads to nowhere," redirecting the proteins away from other jobs that are key to proper cell function, a new study has found.
Artificial neural networks learn better when they spend time not learning at all
1dDepending on age, humans need 7 to 13 hours of sleep per 24 hours. During this time, a lot happens: Heart rate, breathing and metabolism ebb and flow; hormone levels adjust; the body relaxes. Not so much in the brain.
Elizabeth Holmes Sentenced to More Than 11 Years in Prison for Theranos Fraud
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1dHolmes Years Theranos
A few short years ago, media reports were holding up Theranos founder and CEO Elizabeth Holmes as the next Steve Jobs, a comparison she clearly invited with her trademark black turtleneck and deep speaking voice. However, the company's supposedly revolutionary blood testing technology didn't work, and Holmes now stands convicted of multiple counts of wire fraud. After numerous delays due to the C
Tetraplegic Patients Take Mind-Controlled Wheelchair for a Spin
1dThe mobility device interprets its paralyzed user's thoughts to steer through cluttered spaces, a study reports.
Is it true that " most neuroscientists don't consider the default mode network to be meaningful or even real?"
1dSomeone asserted this in another discussion and I thought I'd bring it to the front. submitted by /u/saijanai [link] [comments]
An enantioselective four-component reaction via assembling two reaction intermediates
1dNature Communications, Published online: 18 November 2022; doi:10.1038/s41467-022-34913-2 The interception of one chemical intermediate with another intermediate is very challenging, as intermediates may be incompatible or too reactive, but could result in a streamlined method of organic synthesis. Here, the authors demonstrate enantioselective four-component reactions via the coupling of two int
Twitter Claims Video of Moon Rocket Launch Is Revenge Porn
1dNice Rocket Revenge porn is a horrible thing , and Twitter should definitely continue to ban anyone who attempts to post it on the app. That being said, a video of a rocket taking off — an actual rocket, you pervs — does not revenge porn make, and shouldn't be flagged as such. It seems like a silly thing to have to say, but such is the exact situation that spaceflight photographer John Kraus foun
4.6 billion-year-old meteorite may reveal the origin of Earth's water
1dThe rock is 4.6 billion years old, meaning it was around at the beginning of the solar system
The Taylor Swift Chaos Is a Reckoning for Ticketmaster
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1dTicketmaster Taylor Swift
The company faces scrutiny after botching sales for the artist's Eras Tour. But people have complained about its grip on the ticketing industry for years.
Can pharmacotherapies prevent alcohol use disorder in people with PTSD?
1dA research team showed how drugs can reduce alcohol preference in animal models of post-traumatic stress disorder.
Interdisciplinary guidelines to optimize the treatment of childhood arthritis at global level
1dSo far, there no uniform guidelines have existed for the treatment of arthritis of the jaw, a potentially debilitating consequence of juvenile arthritis.
A Tale of Terroir: Porcini mushrooms have evolved with a preference to local adaptation
1dA genetic survey of porcini mushrooms across the Northern Hemisphere found that these delicious fungi evolved in surprising ways — contrary to the expectations of many who think that geographic isolation would be the primary driver for species diversity. In fact, there are regions in the world where porcini maintain their genetic distinctiveness in local ecological niches, even if they are not is
How Taylor Swift Broke Ticketmaster
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1dTaylor Swift Ticketmaster
Make no mistake: Ticketmaster deserves the scorn that it is currently receiving from Taylor Swift's listenership, a population of such size and power that it probably merits a spot in the United Nations. Earlier this week, the company's just-for-fans presale of tickets to Swift's 2023 concert tour was riddled with bugs and delays. More shocking, Ticketmaster then canceled the general-public sale
COP27: Forecasting overhaul may reduce extreme weather hazards
1dA UN program to revamp weather forecasting in lower-income countries could improve global climate models and help people prepare for extreme weather events
The Smell of Food Affects Metabolism in Fasting Mice
1dThe odor prompted the animals' fat cells to release lipids into circulation.
New study identifies connection between diabetes medications, multiple sclerosis
1dA study has found that anti-hyperglycemic medications used to treat Type 2 diabetes resulted in an increased risk of multiple sclerosis for people older than 45, particularly among women.
Personal sensing at work: Tracking burnout, balancing privacy
1dPersonal sensing data could help monitor and alleviate stress among resident physicians, although privacy concerns over who sees the information and for what purposes must be addressed, according to collaborative research.
The protein behind immunotherapy resistance
1dScientists have identified a key protein that helps tumors evade attacks by the immune system, contributing to poor responses to immunotherapy in the clinic.
Inducing hibernation-like state in mice can protect organs during heart surgery
1dResearchers have developed a new method of protecting organs during heart and aortic surgery when blood circulation has to be blocked. Rather than relying on cold temperatures to induce hypometabolism and reduce the need for oxygen, the technique works by stimulating Q neurons in the brain, which slows metabolism down to a hibernation-like state. The findings could lead to new ways of performing s
Social bees travel greater distances for food than their solitary counterparts, study finds
1dSocial bees such as honeybees and bumblebees have larger foraging ranges, according to researchers.
NASA really, really won't rename Webb telescope despite community pushback
1dNature, Published online: 18 November 2022; doi:10.1038/d41586-022-03787-1 Investigation by agency historian finds no evidence explicitly linking former director James Webb with anti-LGBT+ actions.
NASA Tells Astronauts That Tweeting Isn't As Important as Staying Alive
1dStayin' Alive NASA's astronaut social media handbook just dropped — and they've got some staunch guidelines for space tweeting. As part of a public records request, NASA released to Vox an almost entirely unredacted copy of its current social media handbook for astronauts , and it offers a fascinating look into the agency's policies for the online astronauts it sends to space. Overall, it's a rea
Elon Musk Locks Twitter Employees Out Office, Then Asks Them to Meet Him on the 10th Floor
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1dTwitter Musk Offices
Worst Case Scenario Elon Musk's Twitter-buying experiment is somehow going even worse than expected, amid reports that he's locked employees out of the company's office buildings. As reported by Platformer 's Zoë Schiffer , an email sent to Twitter staff yesterday evening informed them out of the blue that they wouldn't be able to get into their offices for the rest of the week. "We're hearing th
Rare triple dip La Niña expected to occur for first time this century
1dThe eastern Pacific is expected to be unusually cold for the third winter in a row, contributing along with climate change to extreme precipitation and drought
Accessing chiral sulfones bearing quaternary carbon stereocenters via photoinduced radical sulfur dioxide insertion and Truce–Smiles rearrangement
1dNature Communications, Published online: 18 November 2022; doi:10.1038/s41467-022-34836-y The preparation of chiral sulfones featuring quaternary carbon stereocenters remains challenging. Here the authors report the synthesis of such compounds via a multicomponent reaction involving a photoinduced radical sulfur dioxide insertion followed by an asymmetric Truce–Smiles rearrangement.
Global crop yields can be lifted by timely adaptation of growing periods to climate change
1dNature Communications, Published online: 18 November 2022; doi:10.1038/s41467-022-34411-5 'Crop growing periods and cultivars are key to crop adaptation. Here, the authors use a modelling approach that integrates farmers decision and biophysical crop models, showing the importance of cultivar, sowing date and growing period adaptation.'
Author Correction: Predicting potential global and future distributions of the African armyworm (Spodoptera exempta) using species distribution models
1dScientific Reports, Published online: 18 November 2022; doi:10.1038/s41598-022-24222-5 Author Correction: Predicting potential global and future distributions of the African armyworm ( Spodoptera exempta ) using species distribution models
1d
Mice Fed a Highly Processed Diet Are More Susceptible to the Flu
1dIt's not clear why grain-fed mice are better able to recover after infection, but a study's findings suggest food type may skew the results of animal studies.
NASA once again declines to rename the James Webb Space Telescope
1dNASA says an extensive review of historical records found no evidence that Webb ever led or supported purges of government employees who were gay. But some astronomers think that's a pretty low bar. (Image credit: NASA GSFC/CIL/Adriana Manrique Gutierrez)
CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy | Science Advances
1dAbstract Tumors exploit numerous immune checkpoints, including those deployed by myeloid cells to curtail antitumor immunity. Here, we show that the C-type lectin receptor CLEC-1 expressed by myeloid cells senses dead cells killed by programmed necrosis. Moreover, we identified Tripartite Motif Containing 21 (TRIM21) as an endogenous ligand overexpressed in various cancers. We observed that the c
First field evidence of the electrical multipolar nature of volcanic aggregates | Science Advances
1dAbstract The description of the formation of ash aggregates is crucial to our understanding of tephra dispersal and, therefore, to the forecasting of volcanic ash concentration in the atmosphere. Regardless of the importance of electrostatic processes, particle and aggregate charge is of complex determination both in the field and in the laboratory. We have measured the bulk charge carried by sin
Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer's disease progression and heterogeneity | Science Advances
1dAbstract Alzheimer's disease (AD) is a heterogeneous disorder with abnormalities in multiple biological domains. In an advanced machine learning analysis of postmortem brain and in vivo blood multi-omics molecular data ( N = 1863), we integrated epigenomic, transcriptomic, proteomic, and metabolomic profiles into a multilevel biological AD taxonomy. We obtained a personalized multilevel molecular
A balance of noncanonical Semaphorin signaling from the cerebrospinal fluid regulates apical cell dynamics during corticogenesis | Science Advances
1dAbstract During corticogenesis, dynamic regulation of apical adhesion is fundamental to generate correct numbers and cell identities. While radial glial cells (RGCs) maintain basal and apical anchors, basal progenitors and neurons detach and settle at distal positions from the apical border. Whether diffusible signals delivered from the cerebrospinal fluid (CSF) contribute to the regulation of ap
A unified approach and descriptor for the thermal expansion of two-dimensional transition metal dichalcogenide monolayers | Science Advances
1dAbstract Two-dimensional (2D) materials have enabled promising applications in modern miniaturized devices. However, device operation may lead to substantial temperature rise and thermal stress, resulting in device failure. To address such thermal challenges, the thermal expansion coefficient (TEC) needs to be well understood. Here, we characterize the in-plane TECs of transition metal dichalcoge
Diabetic hyperglycemia promotes primary tumor progression through glycation-induced tumor extracellular matrix stiffening | Science Advances
1dAbstract Diabetes mellitus is a complex metabolic disorder that is associated with an increased risk of breast cancer. Despite this correlation, the interplay between tumor progression and diabetes, particularly with regard to stiffening of the extracellular matrix, is still mechanistically unclear. Here, we established a murine model where hyperglycemia was induced before breast tumor developmen
Flies trade off stability and performance via adaptive compensation to wing damage | Science Advances
1dAbstract Physical injury often impairs mobility, which can have dire consequences for survival in animals. Revealing mechanisms of robust biological intelligence to prevent system failure can provide critical insights into how complex brains generate adaptive movement and inspiration to design fault-tolerant robots. For flying animals, physical injury to a wing can have severe consequences, as fl
Rapid marine oxygen variability: Driver of the Late Ordovician mass extinction | Science Advances
1dAbstract The timing and connections between global cooling, marine redox conditions, and biotic turnover are underconstrained for the Late Ordovician. The second most severe mass extinction occurred at the end of the Ordovician period, resulting in ~85% loss of marine species between two extinction pulses. As the only "Big 5" extinction that occurred during icehouse conditions, this interval is a
Genetic slippage after sex maintains diversity for parasite resistance in a natural host population | Science Advances
1dAbstract Although parasite-mediated selection is a major driver of host evolution, its influence on genetic variation for parasite resistance is not yet well understood. We monitored resistance in a large population of the planktonic crustacean Daphnia magna over 8 years, as it underwent yearly epidemics of the bacterial pathogen Pasteuria ramosa . We observed cyclic dynamics of resistance: Resis
Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade | Science Advances
1dAbstract Despite the challenges in treating glioblastomas (GBMs) with immune adjuvants, increasing evidence suggests that targeting the immune cells within the tumor microenvironment (TME) can lead to improved responses. Here, we present a closed-loop controlled, microbubble-enhanced focused ultrasound (MB-FUS) system and test its abilities to safely and effectively treat GBMs using immune checkp
Chiroptical activity of gas-phase propylene oxide predicting the handedness of interstellar circular polarization in the presolar nebula | Science Advances
1dAbstract Propylene oxide, the first chiral molecule recently detected in the interstellar medium, has once again raised the question whether biomolecular chirality might have cosmic origins. However, accurate chiroptical properties of propylene oxide in the ultraviolet spectral range necessary to suggest possible asymmetric synthetic routes in the gas phase are scarce. Here, we report on the firs
Nonstop mRNAs generate a ground state of mitochondrial gene expression noise | Science Advances
1dAbstract A stop codon within the mRNA facilitates coordinated termination of protein synthesis, releasing the nascent polypeptide from the ribosome. This essential step in gene expression is impeded with transcripts lacking a stop codon, generating nonstop ribosome complexes. Here, we use deep sequencing to investigate sources of nonstop mRNAs generated from the human mitochondrial genome. We ide
Articular fibrocartilage-targeted therapy by microtubule stabilization | Science Advances
1dAbstract The fibrocartilage presented on the joint surface was caused by cartilage injury or degeneration. There is still a lack of effective strategies for fibrocartilage. Here, we hypothesized that the fibrocartilage could be viewed as a raw material for the renewal of hyaline cartilage and proposed a previously unidentified strategy of cartilage regeneration, namely, "fibrocartilage hyalinizat
SARS-CoV-2 Omicron BA.1 and BA.2 are attenuated in rhesus macaques as compared to Delta | Science Advances
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1dOmicron BA.2 Delta
Abstract Since the emergence of SARS-CoV-2, five different variants of concern (VOCs) have been identified: Alpha, Beta, Gamma, Delta, and Omicron. Because of confounding factors in the human population, such as preexisting immunity, comparing severity of disease caused by different VOCs is challenging. Here, we investigate disease progression in the rhesus macaque model upon inoculation with the
A bistable and reconfigurable molecular system with encodable bonds | Science Advances
1dAbstract Molecular systems with ability to controllably transform between different conformations play pivotal roles in regulating biochemical functions. Here, we report the design of a bistable DNA origami four-way junction (DOJ) molecular system that adopts two distinct stable conformations with controllable reconfigurability by using conformation-controlled base stacking. Exquisite control ove
Fruit flies use corrective movements to maintain stability after injury
1dFruit flies can quickly compensate for catastrophic wing injuries, researchers found, maintaining the same stability after losing up to 40% of a wing. This finding could inform the design of versatile robots, which face the similar challenge of having to quickly adapt to mishaps in the field.
How '2D' materials expand
1dResearchers developed a technique to effectively measure the thermal expansion coefficient of two-dimensional materials. With this information, engineers could more effectively and efficiently use these atomically-thin materials to develop next-generation electronic devices that can perform better and run faster than those built with conventional materials.
Asphaltene changed into graphene for composites
1dThe flash Joule heating process turns asphaltenes, a byproduct of crude oil production, into graphene for use in composite materials.
'Butterfly bot' is fastest swimming soft robot yet
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1dRobot Butterfly Bot
Inspired by the biomechanics of the manta ray, researchers have developed an energy-efficient soft robot that can swim more than four times faster than previous swimming soft robots. The robots are called 'butterfly bots,' because their swimming motion resembles the way a person's arms move when they are swimming the butterfly stroke.
Structural basis for recognition of transcriptional terminator structures by ProQ/FinO domain RNA chaperones
1dNature Communications, Published online: 18 November 2022; doi:10.1038/s41467-022-34875-5 In this work, the authors determine the crystal structure of a ProQ/FinO RNA chaperone bound to its RNA target. This provides insight into how this family of bacterial proteins recognize transcriptional terminator structures.
Ticketmaster May Have Finally Met Its Match: Furious Swifties
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1dTaylor Swift Ticketmaster
The notorious ticket peddling service Ticketmaster has never been a fan favorite, and anyone who's ever bought a concert ticket there can attest to why. Preposterous prices, slimy junk fees, and terrible customer service are just a few of its mundane evils. In spite of how universally reviled it is, Ticketmaster has persisted as the king of the box office. But now, it's facing its worst PR nightm
Fruit flies use corrective movements to maintain stability after injury
1dFruit flies can quickly compensate for catastrophic wing injuries, researchers found, maintaining the same stability after losing up to 40% of a wing. This finding could inform the design of versatile robots, which face the similar challenge of having to quickly adapt to mishaps in the field.
Abdominal pain is a main manifestation of delayed bleeding after splenic injury in patients receiving non-operative management
1dScientific Reports, Published online: 18 November 2022; doi:10.1038/s41598-022-24399-9
Twitter Chaos Endangers Public Safety, Emergency Managers Warn
1dTwitter is a crucial communication tool during disasters, but impersonators and other problems under Elon Musk's leadership have emergency managers on edge
Clinical trials often exclude people with intellectual disabilities
1d, a new study shows. Scientific breakthroughs aren't possible without the painstaking process of clinical trials. So what happens when many of those trials leave out large portions of the population? Katherine McDonald, a professor of public health at Syracuse University, and associate dean of research in the Falk College of Sport and Human Dynamics, focuses her research around the theme of creat
Butterfly stroke propels swimming robot to record speed
1dNature, Published online: 18 November 2022; doi:10.1038/d41586-022-03603-w Soft robot that snaps its 'wings' overcomes the inefficiency of earlier swimming devices.
Tiny clam that was thought to be extinct found alive
1dThe only evidence of a species of centimetre-long white clam was a fossil collected 85 years ago, until a researcher stumbled upon one living on the shores near Santa Barbara, California
Rare liver cancer is 'addicted' to 1 specific gene mutation
1dA new study shows that a rare kind of liver tumor needs one specific mutation in order to thrive, and that impeding the mutated oncogene reduces tumor growth in mice. Fibrolamellar carcinoma is a rare and lethal liver cancer that disproportionately harms young adults. It is nearly incurable. Surgery can remove the tumor, but no existing therapies are capable of reining in the cancer once it start
FDA Approves a Drug That Can Delay Type 1 Diabetes
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1dFDA Type 1 Diabetes
The therapy will cost nearly $200,000. But it's the first treatment in 100 years to alter the course of the disease, which usually begins in adolescence.
Do not adjust your clock: scientists call time on the leap second
1dSecond added periodically to synchronise atomic time and Earth time can cause problems for GPS systems, software and telecoms Scientists and government representatives meeting at a conference in France have voted to scrap leap seconds by 2035, the organisation responsible for global timekeeping has said. Similar to leap years, leap seconds have been periodically added to clocks over the last half
How Close Are We to Nuclear War?
1dOn Tuesday, a missile landed in Przewodów, a Polish village near the border with Ukraine. Two people were killed in the blast. Their deaths were a direct consequence of Russia's ongoing invasion of Ukraine, though in the fog of war it was not immediately clear which side was to blame. Initial theories held that the missile had been fired by Russia at Ukraine and gone astray, though later U.S. int
Bacteria sensors report when they find chemical invaders
1dResearchers have engineered bacteria to quickly sense and report on the presence of a variety of contaminants in the environment. Their study in Nature shows the cells can be programmed to identify chemical invaders and report within minutes by releasing a detectable electrical current. Such "smart" devices could power themselves by scavenging energy in the environment as they monitor conditions
NASA Orders Press Not to Photograph Launch Site After Moon Mission Takes Off
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1dNASA Artemis 1 Moon
No Photos, Please NASA barred the press from photographing the launch site of its Space Launch System after it boosted the agency's Artemis I Moon mission into space earlier this week. Multiple space reporters said on Twitter that the agency had sent them a message telling them they were prohibited from photographing the Artemis 1 launch tower after the liftoff. "NASA did not provide a reason," E
Twitter Chaos Endangers Public Safety, Emergency Managers Warn
1dTwitter is a crucial communication tool during disasters, but impersonators and other problems under Elon Musk's leadership have emergency managers on edge
Earth weighs in at six ronnagrams as new prefixes picked for big and small
1dRonna, quetta, ronto and quecto added to International System of Units in first such change for more than 30 years Experts have voted for an expansion of the universe – or at least the official terminology that can be drawn upon to describe the vanishingly small and the preposterously large. In a vote at the General Conference on Weights and Measures in Versailles on Friday, the International Sys
A glutamine-based single α-helix scaffold to target globular proteins
1dNature Communications, Published online: 18 November 2022; doi:10.1038/s41467-022-34793-6 Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.
1st ever drug to delay type 1 diabetes approved by FDA
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1dFDA Type 1 Diabetes
Teplizumab-mzwv is the first drug ever approved to prevent type 1 diabetes in those who are destined to develop the disease.
Titanic 12-foot turtle cruised the ocean 80 million years ago, newfound fossils show
1dResearchers in Spain have unearthed a never-before-seen species of ancient marine turtle, the largest of its kind ever uncovered in Europe.
Dietary change starves cancer cells, overcoming treatment resistance
1dA dietary change could be a key to enhancing colon cancer treatment, a new study finds. Researchers found in cells and in mice that a low-protein diet blocked the nutrient signaling pathway that fires up a master regulator of cancer growth.
Brain organoids reveal in detail the harms of prenatal alcohol exposure
1dNo amount of alcohol consumption is safe for a developing fetus. A new study presents in molecular detail how alcohol harms growth and functioning of developing brain organoids.
How Webb's NIRSpec instrument opened up 200 windows to our origins
1dAstronomy is driven by big questions, and they don't come much bigger than wondering how the first stars and galaxies began to form—eventually giving rise to our own existence.
Researchers discover Egypt's oldest tomb oriented to winter solstice
1dResearchers of the University of Malaga (UMA) and the University of Jaen (UJA) have discovered Egypt's oldest tomb oriented to the winter solstice. Located in the necropolis of Qubbet el-Hawa (Aswan), it is precisely oriented to the sunrise of the winter solstice, in such a way that the sun's rays bathed with its light the place that was intended to house the statue of a governor of the city of El
Researchers turn asphaltene into graphene for composites
1dAsphaltenes, a byproduct of crude oil production, are a waste material with potential. Rice University scientists are determined to find it by converting the carbon-rich resource into useful graphene.
Looking at oxygen storage dynamics in three-way catalysts
1dIn light of vehicular pollutants contributing to decreasing air quality, governments across the globe are posing stricter emission regulations for automobiles. This calls for the development of more efficient exhaust gas after-treatment systems, which are systems to "clean" exhaust gas before it is released into the atmosphere).
New technique accurately measures how 2D materials expand when heated
1dTwo-dimensional materials, which consist of just a single layer of atoms, can be packed together more densely than conventional materials, so they could be used to make transistors, solar cells, LEDs, and other devices that run faster and perform better.
Fruit flies use corrective movements to maintain stability after injury
1dFruit flies can quickly compensate for catastrophic wing injuries, researchers found, maintaining the same stability after losing up to 40% of a wing. This finding could inform the design of versatile robots, which face the similar challenge of having to quickly adapt to mishaps in the field.
Fruit flies use corrective movements to maintain stability after injury
1dFruit flies can quickly compensate for catastrophic wing injuries, researchers found, maintaining the same stability after losing up to 40% of a wing. This finding could inform the design of versatile robots, which face the similar challenge of having to quickly adapt to mishaps in the field.
15 Best Black Friday Microsoft Deals (2022): Xbox Series S, Surface Laptops
1dRight now, you'll find discounts on Windows laptops and hundreds of video games on the Microsoft Store.
Silver-enhanced colloidal gold dip strip immunoassay integrated with smartphone-based colorimetry for sensitive detection of cardiac marker troponin I
1dScientific Reports, Published online: 18 November 2022; doi:10.1038/s41598-022-24458-1
Warming Worsened West Africa Floods That Killed 800 People
1dUnusually heavy monsoon rains that caused deadly flooding in Nigeria were made 80 percent more likely by climate change
The Persistence of (T Cell) Memory: Towards Cellular Therapy for Solid Tumors
1dIn this webinar, Douglas Green will describe how early events in T cell activation influence anti-tumor immunity.
Worldwide dataset captures Earth in finest ever detail
1dA global open-source dataset of high-resolution images of Earth—the most extensive and detailed of its kind—has been developed by experts led by UCL with data from the European Space Agency (ESA).
School choice motivated midterm voters in superintendent races. What that means for students
1dPandemic-related school closures at neighborhood public schools led parents to wonder what other options they had. Many voted for the people they hope will give them more choices as they chose state superintendents on their midterm ballots this month.
Scientists develop new fertilizer from food chain waste
1dResearchers from the Università Cattolica at Piacenza, have developed a new fertilizer from food chain waste, specifically from the waste of the productions of lactic acid bacteria that currently have to be eliminated through purification processes.
UK tech founders and science chiefs attack chancellor's R&D tax raid
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1dUK Autumn SME R&D Tax
Jeremy Hunt made the levy relief, seen as a lifeline for small companies, less generous in the Autumn Statement
Scientists develop new fertilizer from food chain waste
1dResearchers from the Università Cattolica at Piacenza, have developed a new fertilizer from food chain waste, specifically from the waste of the productions of lactic acid bacteria that currently have to be eliminated through purification processes.
In 'momentous' act, regulators approve demolition of four Klamath River dams
1dIn a milestone decision, federal regulators on Thursday signed off on plans to demolish four aging dams along the Klamath River, paving the way for hundreds of miles of native fish habitat along the California-Oregon border to flow freely for the first time in more than a century.
Novel AI blood test detects liver cancer
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1dCancer
A novel artificial intelligence blood testing technology has been used to successfully detect lung cancer in a 2021 study has now detected more than 80% of liver cancers in a new study of 724 people.
Newly developed gene classifier identifies risk of pre-breast cancer progression
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1dInstitute London Cancer
Researchers mapping a molecular atlas for ductal carcinoma in situ (DCIS) have made a major advance toward distinguishing whether the early pre-cancers in the breast will develop into invasive cancers or remain stable.
Scientists build nanoscale parapets, aqueducts, and other shapes
1dScientists have developed a new way to guide the self-assembly of a wide range of novel nanoscale structures using simple layered block copolymers as starting materials. The work could help guide the design of custom surface coatings with tailored optical, electronic, and mechanical properties for use in sensors, batteries, filters, and more.
Legacy of a molecular dynamics trailblazer
1dPhysicists explains how the theoretical chemist Martin Karplus and his team applied the approach of molecular dynamics simulation to a large biological molecule, a protein, deeply impacting biology and the physical sciences in the 20th and 21st centuries.
With training, people in mind-controlled wheelchairs can navigate normal, cluttered spaces
1dA mind-controlled wheelchair can help a paralyzed person gain new mobility by translating users' thoughts into mechanical commands. Researchers now demonstrate that tetraplegic users can operate mind-controlled wheelchairs in a natural, cluttered environment after training for an extended period.
Engineers solve a mystery on the path to smaller, lighter batteries
1dA new discovery could finally usher the development of solid-state lithium batteries, which would be more lightweight, compact, and safe than current lithium batteries. The growth of metallic filaments called dendrites within the solid electrolyte has been a longstanding obstacle, but the new study explains how dendrites form and how to divert them.
Turning wastewater into fertilizer is feasible and could help to make agriculture more sustainable
1dThe wastewater draining from massive pools of sewage sludge has the potential to play a role in more sustainable agriculture, according to environmental engineering researchers.
Unusual type of antibody shows ultrapotent activity against Zika
1dAn unusual type of antibody that even at miniscule levels neutralizes the Zika virus and renders the virus infection undetectable in preclinical models has been identified.
In 'momentous' act, regulators approve demolition of four Klamath River dams
1dIn a milestone decision, federal regulators on Thursday signed off on plans to demolish four aging dams along the Klamath River, paving the way for hundreds of miles of native fish habitat along the California-Oregon border to flow freely for the first time in more than a century.
Decolonizing the biosciences: Turning lip service into action
1dNature, Published online: 18 November 2022; doi:10.1038/d41586-022-03785-3 Prevent 'equity washing' by making research collaborations with level partnerships.
'Labour advantage' drives greater productivity at elite universities
1dNature, Published online: 18 November 2022; doi:10.1038/d41586-022-03784-4 Massive study shows how having more staff and students allows scientists at prestigious US institutions to publish more research.
How well do state-of-the-art climate models simulate sea level?
1dAccording to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change, the global mean sea level has risen faster since 1900 than over any preceding century in the last 3000 years. This makes hundreds of coastal cities and millions of people vulnerable to a threat of higher water levels.
Researchers develop a novel integration scheme for efficient coupling between III-V and silicon
1dResearchers at the Hong Kong University of Science and Technology (HKUST) has recently developed a novel integration scheme for efficient coupling between III-V compound semiconductor devices and silicon components on silicon photonics (Si-photonics) platform by selective direct epitaxy, unlocking the potential of integrating energy-efficient photonics with cost-effective electronics, as well as e
You could opt to pay extra on your next flight to help the planet. But is it a waste of money?
1dFor people trying to lower their carbon footprint in the world, flying is a conundrum.
Honey bees prosper with quality, not quantity, of food in novel laboratory setup
1dHoney bee workers collect pollen and nectar from a variety of flowering plants to use as a food source. Honey bees typically forage from up to 1-2 miles away from the hive, though sometimes they travel even further, including up to 10 miles away. However, much of the modern landscape consists of agricultural fields, which limits the foraging options for honey bees in these areas.
A new optical inversion strategy for unscrambling light propagation through multimode optical fibers
1dMultimode optical fibers (MMFs) are hair-thin strands of glass that are ubiquitous in light-guiding applications. Their development has gone hand-in-hand with the huge growth in rapid transmission of information across the world.
Save the economy, save the planet, says sustainability expert
1dA new book by UVM economist Jon Erickson, "The Progress Illusion: Reclaiming Our Future from the Fairytale of Economics" (Island Press, Dec. 1) explores the harsh economic realities that have led to sky-high inflation, growing inequality, polarized politics, and climate crisis.
Food marketing and research on kids lacks government oversight
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1d56% Food Marketing Kids
Federal regulations ban tobacco companies from advertising to kids and prohibit profanity on television before 10 p.m. But what is protecting children from predatory advertising of junk food, especially with sneaky online marketing tactics like the use of influencers?
From the air, scientists map 'fast paths' for recharging California's groundwater
1dThousands of years ago during the last Ice Age, rivers flowed from giant glaciers in the Sierra Nevada down to the Central Valley, carving into rock and gouging channels at a time when the sea level was about 400 feet lower. When the glaciers retreated, meltwater coursed down and buried the river channels in sediment.
Opinion: Tackling the climate crisis beyond COP
1dThe clock is ticking. The 27th United Nations Framework Convention on Climate Change (UNFCCC) Conference of the Parties (COP27) is nearly halfway through. Beyond the nice words, some announcements designed to make headlines and more explanations about how bad the climate crisis is, COP27's outputs and results are far from what the world expects and what the planet needs.
Turning wastewater into fertilizer is feasible and could make agriculture more sustainable
1dThe wastewater draining from massive pools of sewage sludge has the potential to play a role in more sustainable agriculture, according to environmental engineering researchers at Drexel University.
This Is How an Alzheimer's Gene Ravages the Brain
1dStudy in cells and mice suggests that the variant APOE4 affects the all-important insulation around nerve cells
Honey bees prosper with quality, not quantity, of food in novel laboratory setup
1dHoney bee workers collect pollen and nectar from a variety of flowering plants to use as a food source. Honey bees typically forage from up to 1-2 miles away from the hive, though sometimes they travel even further, including up to 10 miles away. However, much of the modern landscape consists of agricultural fields, which limits the foraging options for honey bees in these areas.
Wyze Scale X review
1dThe Wyze Scale X is an affordable and well-designed smart scale that can easily track your health and fitness.
Save $150 on the M2 MacBook Air in this Black Friday laptop deal
1dApple's latest and greatest MacBook Air is reduced by $150 at Best Buy – ideal for students looking to upgrade.
Scientists want to build an 'interstellar interceptor' to play hide-and-seek with the next 'Oumuamua
1dResearchers want to build a spacecraft to lurk in far-Earth orbit and chase down interstellar objects as they whizz through the solar system.
NASA Drops Stunning New James Webb Image of a Star Being Born
1dBirth Canal The James Webb Space Telescope's latest mind-bending image just dropped — and this one is, in a word, splendid. As NASA notes in a blog post about the finding, the telescope's Near-Infrared Camera (NIRCam) was put to incredible use when capturing the "once-hidden features" of the beginnings of a star. Known as "protostars," celestial objects like this one — found inside an uber-absorb
Legacy of a molecular dynamics trailblazer
1dPhysicists explains how the theoretical chemist Martin Karplus and his team applied the approach of molecular dynamics simulation to a large biological molecule, a protein, deeply impacting biology and the physical sciences in the 20th and 21st centuries.
With training, people in mind-controlled wheelchairs can navigate normal, cluttered spaces
1dA mind-controlled wheelchair can help a paralyzed person gain new mobility by translating users' thoughts into mechanical commands. Researchers now demonstrate that tetraplegic users can operate mind-controlled wheelchairs in a natural, cluttered environment after training for an extended period.
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