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End 'colonial' approach to space exploration, scientists urge
 
 
 
 

Focus should shift away from seeking to exploit discoveries on other planets, researchers say

Humans boldly going into space should echo the guiding principle of Captain Kirk's Star Trek crew by resisting the urge to interfere, researchers have said, stressing a need to end a colonial approach to exploration.

Nasa has made no secret of its desire to mine the moon for metals, with China also keen to extract lunar resources – a situation that has been called a new space race.

Continue reading…
 
 
 

TODAY

 
 

Nature Communications, Published online: 04 March 2023; doi:10.1038/s41467-023-36758-9

Salmonella typhimurium translocates numerous effectors via its type III secretion system. Here, Göser et al. present a characterisation of selected proteins and their dynamic interaction with Salmonella-containing vacuoles and – induced filaments.
 
 
 
Multiplexed analysis of EV reveals specific biomarker composition with diagnostic impact
 
 
 
 

Nature Communications, Published online: 04 March 2023; doi:10.1038/s41467-023-36932-z

Multiplexed analyses of near single 
EVs
 is currently challenging. Here the authors report the method MASEV, multiplexed analysis of EVs, to interrogate thousands of individual EVs during 5 cycles of multi-channel fluorescence staining for 15 EV biomarkers.
 
 
 
 
 

Nature Communications, Published online: 04 March 2023; doi:10.1038/s41467-023-36964-5

Cyanobacteria mutants with improved tolerance to combined high light and high temperature (HLHT) are rarely reported. Here, the authors use a hypermutation system for adaptive laboratory evolution and identify a mutant with improved HLHT tolerance by enhancing expression of shikimate kinase.
 
 
 
 
Is this article about Food Science?
 
Obese fruit flies are the experimental subjects in a Nature Communications study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels.
 
 
 
 
Is this article about Food Science?
 
Obese fruit flies are the experimental subjects in a Nature Communications study of the causes of muscle function decline due to obesity. In humans, skeletal muscle plays a crucial role in metabolism, and muscle dysfunction due to human obesity can lead to insulin resistance and reduced energy levels.
 
 
 
Structural basis of HIV-1 maturation inhibitor binding and activity
 
 
 
 

Nature Communications, Published online: 04 March 2023; doi:10.1038/s41467-023-36569-y

HIV maturation inhibitors such as bevirimat (BVM) interfering with Gag processing are emerging as alternative anti-retroviral drug candidates. Here, the authors report structures of assemblies of HIV-1 Gag fragments spanning the CA C-terminal domain and SP1 region bound to BVM.
 
 
 
 
 

Nature Communications, Published online: 04 March 2023; doi:10.1038/s41467-023-36939-6

Fast-growing bamboo still need advanced processing before being fabricated into sustainable structural materials. Here, the authors develop high-performance TiO2 reinforced densified bamboo via in situ hydrothermal synthesis and reveal the flexural failure mechanism of the composite.
 
 
 
 
 

Nature Communications, Published online: 04 March 2023; doi:10.1038/s41467-023-36968-1

RECQ4
 mutations contribute to multiple developmental diseases and tumorigenesis. Here the authors describe how a highly oncogenic RECQ4 mutation alters the control of DNA synthesis, leading to abnormal DNA content and cell growth.
 
 
 
 
 

Nature Communications, Published online: 04 March 2023; doi:10.1038/s41467-023-36895-1

Although the role of FGFs in 
cardiovascular disease
 has attracted extensive attention, the potential role of 
FGF18
 in pathological 
cardiac hypertrophy
 remains unknown. Here, the authors show the cardioprotective effect of FGF18 is mediated by maintaining redox homeostasis through FYN/Nox4 signaling.
 
 
 
 
Is this article about Energy?
 

Nature Communications, Published online: 04 March 2023; doi:10.1038/s41467-023-36917-y

Reducing energy loss of sub-cells is critical for high performance tandem organic solar cells. Here, the authors design and synthesize an ultra-narrow bandgap acceptor through replacement of terminal thiophene by selenophene in the central fused ring, achieving efficiency of 19% for tandem cells.
 
 
 
AI replacing its own creators before other jobs
 
 
 
Is this article about Advertising?
 

Okay I've seen many people say AI will replace web devs and programmers. Subsequently it will replace it's own creators, Computer Scientists/ML Engineers.

What I don't understand is that how will other jobs not be replaced as well. Isn't it a paradox? Like if AI replace Computer Scientists, then it means AI must be creative and super smart => If AI is creative and smart, then it can evolve alone and become better => If AI evolves alone, then no job is safe.

In case the AI is not smart enough to replace other jobs, then wouldn't we need Computer Scientists again? The cycle goes on…

My question comes from a discussion with a graphic designer and a Mechanical Engineer. They were saying AI will replace Computer Scientists way before many other jobs, so their jobs (Graphic Design and Mechanical Engineering) are safer than Computer Scientists. How would this be possible?

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It's happened to anyone with a cell phone — dropped calls or dead air because suddenly there is no service available. Or worse, the location pin drops on the navigation app. 
Researchers
 are looking at ways to improve cell phone connectivity and localization abilities by examining 'smart' surfaces that can bounce signals from a tower to customers to improve the link. A smart surface involves installing reflective elements on windows or panels on buildings in dense urban environments.
 
 
 
 
 
A new study finds that high school students identify more with math if they see their math teacher treating everyone in the class equitably, especially in racially diverse schools. While the relationship between teacher equity and math identity was evident across races, there was an interesting exception. Black students, in general, had strong math identities, regardless of their teacher's actions.  Learning about the factors that affect student math identity is important because a student's attitude towards the subject influences the courses that they take as well as their future career selections. This study suggests that teachers may have a larger role to play in helping students develop a positive math identity than previously recognized.
 
 
 
 
 
It's happened to anyone with a cell phone — dropped calls or dead air because suddenly there is no service available. Or worse, the location pin drops on the navigation app. 
Researchers
 are looking at ways to improve cell phone connectivity and localization abilities by examining 'smart' surfaces that can bounce signals from a tower to customers to improve the link. A smart surface involves installing reflective elements on windows or panels on buildings in dense urban environments.
 
 
 
 
 
More than 350 former NFL players were studied on average 29 years after their playing careers ended. Retirees who experienced concussion symptoms during their playing careers were found to perform worse on a battery of cognitive tests. When comparing the retired players to more than 5,000 men who did not play football, cognitive performance was generally worse for former players, with older players performing worse.
 
 
 
Fighting friction to protect machinery
 
 
 
 
Moving parts in mechanical come into regular contact, leading to wear and tear. Now, researchers have developed a contact control system, driven by artificial intelligence, to greatly reduce contact between damaged parts.
 
 
 
Acid glia in REM sleep: Stronger acid response in epileptic mice
 
 
 
 
Changes in our REM sleep patterns could potentially be used to diagnose the severity of epilepsy, a new study has suggested. Researchers showed that astrocytes — star-shaped glial cells that control the local ionic and metabotropic environment of the brain — exhibit an acid response with REM sleep in mice. They theorize that the acid response could be the underlying drive for specific information processing and generating plasticity during sleep.
 
 
 
Destroying the superconductivity in a kagome metal
 
 
 
Is this article about Energy Industry?
 
A recent study has uncovered a distinct disorder-driven superconductor-insulator transition. This first electric control of superconductivity and quantum Hall effect in a candidate material for future low-energy electronics has promise to reduce the rising, unsustainable energy cost of computing.
 
 
 
 
Is this article about Smart Cities?
 
Some cities only last a century or two, while others last for a thousand years or more. Often, there aren't clear records left behind to explain why. Instead, archaeologists piece together clues from the cities' remains to search for patterns that help account for why certain places retained their importance longer than others.
 
 
 
Merrick Garland Is No Pushover
 
 
 
 

This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here.

Many critics of Donald Trump concluded long ago that Attorney General Merrick Garland was not equal to the challenge of holding the former president accountable. It might be time for them to reassess.

First, here are three new stories from The Atlantic:


Deliberate Aggression

No one would mistake Merrick Garland for a firebrand. When President Joe Biden nominated him to lead the Justice Department, the former federal judge cited Edward Levi, the attorney general who restored faith in the department after Watergate, as a role model. But Garland faced a potentially more complicated charge than Levi: Whereas Richard Nixon had resigned, been pardoned, and withdrawn from the national stage, Garland had to rebuild the DOJ while also delivering accountability for Trump, who remains unrepentant and is running to return to office.

As weeks turned to months and we passed the one-year mark of Biden's term, Garland's apparently slow pace on the second task rattled observers who worry that Trump will end up facing little punishment for attempting to steal the election and inciting an insurrection—and that he might even return to the White House. But deliberation is not the same as inaction. The first sign that Garland was not as disengaged as he might have seemed came when the FBI executed a warrant at Mar-a-Lago in August, seeking government records—some highly sensitive—that Trump had allegedly improperly taken. And the more we learn, the more aggressive Garland's approach looks.

This week, The Washington Post reported on how the surprise August search was the culmination of a running disagreement between the FBI and Justice Department prosecutors. (All of them ultimately report to Garland.) Some of the FBI officials were reluctant to push Trump too hard and wanted to ask him for permission or to slow-walk the process. My colleague Adam Serwer notes the irony that the bureau, which Trump and Republicans have portrayed as implacably politically opposed to him, was actually quite eager to protect him. But backed by Garland, who personally approved the search, the prosecutors ultimately won the day.

Separately, the Justice Department argued in a court filing yesterday that Trump can be liable for actions of the mob that stormed the Capitol on January 6, 2021. A group of Capitol Police officers and members of the House of Representatives have sued the former president for physical and psychological damage from the riot. Trump's lawyers contend that he cannot be held liable for inciting the riot because he was acting as president at the time, which confers immunity. But the Justice Department disagreed.

"Speaking to the public on matters of public concern is a traditional function of the Presidency, and the outer perimeter of the President's Office includes a vast realm of such speech," government attorneys wrote in the filing. "But that traditional function is one of public communication. It does not include incitement of imminent private violence."

While all of this happens, the criminal investigations into Trump's actions around the 2020 election and the Mar-a-Lago documents are moving swiftly. After Trump announced his presidential campaign in November, Garland appointed Jack Smith, a former Justice Department lawyer, to oversee the probes, and Smith has demonstrated an aggressive streak. In the past month, he has subpoenaed Ivanka Trump, Jared Kushner, and former Vice President Mike Pence. CNN also reports that Smith "is locked in at least eight secret court battles" related to the Trump investigations. (Garland also appointed a special counsel to look into classified documents found in one of Biden's houses and a former office space. He has said that the DOJ can handle an investigation into Hunter Biden, the president's son, internally.)

My colleague Franklin Foer saw all of this coming in an October profile of the attorney general. He wrote that Garland did not seem to relish the position in which he found himself, but that the very qualities that worried Garland's naysayers—his institutionalism, caution, and fastidiousness—were the ones that would likely lead him to indict Trump. "I've reached the conclusion that his devotion to procedure, his belief in the rule of law, and in particular his reverence for the duties, responsibilities, and traditions of the U.S. Department of Justice will cause him to make the most monumental decision an attorney general can make," Frank wrote.

What the attorney general has not managed to do so far is depoliticize public perceptions of the department. By all reports, he's returning a greater professionalism to the department after some of the lowlights of the Trump presidency, but the Mar-a-Lago search and other investigations have made the DOJ a subject of greater political strife. Despite his painstaking approach to the Trump investigations, Garland was grilled by Republicans during a Senate Judiciary Committee hearing this week, and accused (unconvincingly) of conducting a witch hunt against conservatives. An indictment of Trump would only exaggerate complaints of bias from the right.

There is, to be fair, a big gap between investigating and indicting. Trump is clearly upset about how things are going. He issued an angry comment after the DOJ's filing yesterday, and last month released a long, unusual statement, replete with very un-Trumpian footnotes, that I wrote was a preview of the legal strategy he might use if charged with crimes connected to the insurrection. The strategy might work, either as a defense or at least as a deterrence to charges. And, as I reported in January, any case against Trump would also have to move fast, with the goal of concluding before January 20, 2025, when a Republican president could take office and shut it down.

But whatever ultimately happens to Donald Trump, what we've seen over the past month should be enough to put to rest the idea that Garland is letting the former president off easy. Perhaps the Trump years made us forget that the Justice Department can get things done without messy public drama.

Related:


Today's News

  1. The former South Carolina lawyer Alex Murdaugh was convicted of murdering his wife and son, and was sentenced to life in prison.
  2. Merrick Garland made an unannounced trip to Ukraine, according to a Justice Department official. It is his second trip to the country since Russia first invaded.
  3. The storm system that damaged parts of the central U.S. this week is now headed toward New England.

Dispatches

Explore all of our newsletters here.


Evening Read

An illustration of Jeeves from "Ask Jeeves" hatching out of an egg
 
 
Matt Chase / The Atlantic. Source: Getty.

The Vindication of Ask Jeeves

By Charlie Warzel

It was a simpler time. A friend introduced us, pulling up a static yellow webpage using a shaky dial-up modem. A man stood forth, dressed in a dapper black pinstriped suit with a red-accented tie. He held one hand out, as if carrying an imaginary waiter's tray. He looked regal and confident and eminently at my service. "Have a Question?" he beckoned. "Just type it in and click Ask!" And ask, I did. Over and over.

With his steady hand, Jeeves helped me make sense of the tangled mess of the early, pre-Google internet. He wasn't perfect—plenty of context got lost between my inquiries and his responses. Still, my 11-year-old brain always delighted in the idea of a well-coiffed man chauffeuring me down the information superhighway. But things changed.

Read the full article.

More From The Atlantic

Read. Go down the Judy Blume rabbit hole. Our senior editor Amy Weiss-Meyer, who recently wrote a profile of Blume, has a guide to get you started.

And these six memoirs are some of the finest of the form.

Watch. In theaters, Creed III makes an old franchise feel fresh.

And these 20 biopics are actually worth spending time with.

Listen. Jazz just lost Wayne Shorter, one of its all-time greats—and one of the greatest composers the United States has ever produced, David wrote yesterday. Spend some time with Shorter's music this weekend.

Play our daily crossword.


P.S.

Reading news about the train derailment last month in East Palestine, Ohio, has gotten me thinking about disaster songs, one of my favorite niches in the folk-music tradition. Consider the engineer Casey Jones. The U.S. endured several huge wrecks in 1900, but the only one most people might have heard of is the single-fatality crash that claimed Jones's life—because a folk song about him provided him a sort of immortality. Singers have memorialized deadly railroad catastrophesmining disastersstorms, and even the sinking of the Titanic, but if songs like this are being written today, the music industry as it has come to exist precludes any path for them to achieve the same permanence. East Palestine's misfortune is more likely to be recorded in documentary films, whose dominance my colleague Megan Garber described in her great recent cover story. Both media mix fact and fiction to grab an audience; perhaps we can call disaster songs the infotainment of their era.

— David

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Isabel Fattal contributed to this newsletter.

 
 
 
Stop assuming business as usual when talking about future
 
 
 
 

Quick definition for those who don't know: "business as usual" in this context means thinking that the future will look largely the same as today with some generational improvements – faster computers, thinner smartphones, more efficient planes, SUVs which now take two lanes instead of one etc. Basically it's a viewpoint stemming from the assumption that no big change will take place in the foreseeable future.

Let me bring up some general examples from comments on this sub first [square brackets contain general topic] (brackets contain explanations when needed):

  • [lifespan extension] I don't want to work for 200 years before retiring.
  • [lifespan extension] I just want to be healthy longer but I don't want to live longer. (user saying this assumes that death coping like "death is natural part of life" etc. is natural and that they'll want to die at eg. age of 80 and not be allowed to)
  • [automation] How can I live if there is no way for me to make money because there is no jobs?
  • [automation] My job is too hard to be automated.
  • [generative AI] AI will kill human creativity. (user assumes that human creativity will disappear if there is no monetary incentive)
  • [generative AI] I will always recognise AI art.

All of those are statements are short sighted when looking at the whole picture and disappointing when considering that this is supposed to be future focused sub. I am not saying that I am better at predicting future than you or that you should be blindly optimistic (some may classify my critique as something stemming from optimism, I consider myself a realist) but being blindly pessimistic or ignorant of many things changing simultanously isn't the way either.

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When will we have AI lawyers? Humans are far too risky.
 
 
 
 

Thinking about convivted lawyer Alex Murdaugh, a pillar of his community. Stole from 30-50 clients to get high, among other crimes.

https://www.nytimes.com/article/murdaugh-murders-alex-paul.html

Point is, I trust AI way more than humans. Why would I trust a lawyer to handle my finances in an orderly fashion? Worst case, I am disabled or dead, I get robbed.

We should sue for right of costumized AI Software that can represent clients in courts legally. Of course, once the technology is further developed.

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YESTERDAY

Prime Minister of European Country Names AI as Advisor
 
 
 
 
Meet Ion, Romania's "new honorary advisor," who is worryingly in charge of surveilling and interpreting the opinions of its citizens.
 
 

Bot Bureaucrat

Both the rapidly increasing ubiquity and the power of AI can feel terrifying, but at least AIs aren't running the world yet, right?

Well, maybe not the world, but how about Romania? The country's prime minister Nicolae Ciuca has just announced an AI assistant called "Ion" as the government's "new honorary advisor."

"Hello. You gave me life. I am Ion. Now, my role is to represent you. Like a mirror," Ion said while introducing itself at a press conference, as quoted by The Washington Post.

 

Voice of the People

With a mirror-like, monolithic body and a somber, deep voice, you'd be forgiven for comparing Ion to HAL 9000 from the sci-fi classic "2001: A Space Odyssey." But instead of being in charge of a mere spaceship, Ion is responsible for gauging the sentiments of an entire country.

"Ion will do, through artificial intelligence, what no human can: listen to all Romanians and represent them before the government of Romania," Ciuca said.

And by listen, Ciuca really does mean listen. The AI will crawl social media to collect citizens' opinions and grievances, and then amalgamate and interpret these back to the government as policy ideas, who, at least in theory, will use the feedback to inform their decisions.

Concerned citizens can also interact with Ion directly by using a provided web portal if they're really eager to get their point across.

Call for Transparency

The process that Ion uses to pick out social media posts, categorize them, and then formulate policies is about as transparent as its steely, mirrored exterior — that is to say, not very transparent at all.

For critics, that's something to worry about. If Ion's workings aren't transparent, how can its citizens, whom it practically surveils, know it isn't being biased? Could it single those with dissenting opinions out and glean their real identities?

In short, it's a thorny, ethical nightmare waiting to unfold.

"Romanians should be informed and explained how this AI tool selects important posts, and on what criteria," demanded Kris Shrishak, an expert on AI regulation at the Irish Council for Civil Liberties, in an interview with the WaPo. "This should be explained to the public."

Besides, how good are AIs at gauging human opinions, wants, desires, and feelings? If Microsoft's Bing AI chatbot is any indicator, probably not very.

More on AI: Bank of America Obsessed With AI, Says It's the "New Electricity"

The post Prime Minister of European Country Names AI as Advisor appeared first on Futurism.

 
 
 
Dippy the Dinosaur: Understanding the Famed Diplodocus
 
 
 
 
Following its arrival in Coventry, U.K., Dippy the Dinosaur drew over 10,000 visitors in its first week on display. The opening marked the beginning of Dippy's three-year stay at the Herbert Art Gallery and Museum. Dippy is a Diplodocus, or more specifically, a Diplodocus fossil. Diplodocuses were gigantic dinosaurs that lived in the Late Jurassic Period, about 161 to 145 million years ago. The behemoth fossil itself is over 85 feet long and likely weighed between 22,000 to 30,000 pounds when alive. Read More: Meet Ceratosaurus, The Great Horned Beast Of The Jurassic Period What is a Diplodocus? Diplodocuses were giant dinosaurs, like the brontosaurus, and were some of the largest creatures to exist at the time. While Dippy was just over 85 feet long, the Diplodocus could actually grow up to 92 feet in length, according to current fossil records. However, Dippy was near the peak of a Diplodocus' possible weight since the max weight of a Diplodocus was around 30,000 pounds. This is much lighter than other dinosaurs of a similar size. For example, an Apatosaurus of the same length would have weighed twice as much as a Diplodocus. Much like other large dinosaurs, the Diplodocus achieved its extreme size as an herbivore. It had pencil-like teeth that it used to strip the leaves off low-growing plants and with an extremely long neck, it had plenty of plants to choose from. Researchers have found nearly every Diplodocus fossil in the Morrison Formation in the western U.S. This suggests that Diplodocuses likely stuck to one area during their time on Earth. Additionally, Diplodocus fossils are often found in similar areas to both Allosaur and Stegosaurus fossils. A Famous Fossil The original fossil that Dippy the Dinosaur is based on was discovered in the state of Wyoming in 1899. Andrew Carnegie purchased the fossil to have as a centerpiece in his museum in Pittsburgh. The actual fossil of Dippy remains on display there today. In 1905, a cast of Dippy was gifted to the Natural History Museum in London and remained there for over 100 years before beginning a tour of the U.K. in 2017. While it may seem like Dippy is one complete cast, it is made up of the remains of five different Diplodocuses. There are 10 other fossil casts like Dippy around the world, including ones in Paris, Madrid, Berlin and even La Plata, Argentina.
 
 
 
What Is the Default Mode Network?
 
 
 
 
You might be the laziest person on the planet, but your brain never rests. So what does it get up to when you're more or less checked out? In the 1930s, Hans Berger, a German psychiatrist who had recently invented the electroencephalogram (EEG), suggested that our brains are always active, even when we don't seem to be doing much with them. Few people took the idea seriously at the time (maybe because Berger had spent much of his career trying to prove telepathy, or perhaps because he was just ahead of his time). Some 40 years later, in the 1970s, researchers confirmed that blood flow to the brain, a useful proxy for brain activity, varies depending on what you're doing. Modern Brain Imaging Still, it was difficult to learn much about which regions of the brain are active during various activities until the advent of modern brain imaging technology, such as positron emission tomography (PET) scans and magnetic resonance imaging (MRI). However, by the turn of the century, scientists were using these technologies to study the brain.  Read More: How Magnetic Brain Scans Could Reveal Brain Age Researchers noticed that when study subjects were resting in the scanner, not doing any particular task (perhaps they were in the control group or just waiting for the experiment to get underway), their brains showed interesting activity patterns. The researchers found that certain brain regions show lower activity levels when we're paying attention to some task but jump into action when we're not engaged in any specific mental task. Berger was right that the brain is always active; in fact, it turns out that it is very active indeed, even during those periods when it was previously thought to be resting. Default Mode Network In 2001, a team led by Marcus Raichle, a neuroscientist at Washington University, published the first of a series of papers describing the phenomenon and giving a name to this network of brain areas: the Default Mode Network (DMN). Read More: Why We Experience Self-Doubt And How to Curb Those Feelings The brain areas involved in the DMN seem to be mostly: the medial prefrontal cortex, the posterior cingulate cortex, part of the inferior parietal lobe, and sometimes, maybe, the middle temporal lobe. Maybe? Yes, scientists are still working to pinpoint which parts of the brain are involved in the DMN. In fact, it may be that there are several DMNs and different combinations of areas that network for different purposes. Brain DMN One thing all these brain areas have in common is that they play a role in the inner voice. The brain's DMN kicks in when we're daydreaming, reminiscing, or thinking about, say, that text your sister sent this morning, what you're having for dinner, noticing that it's getting kind of hot in the room, wondering what your cat is thinking when it looks at you like that, wondering what your sister meant by that text she sent this morning — you know, all those seemingly random thoughts that meander through your mind when you're not focused on anything else. Meanwhile, areas of the brain that are responsible for things like attention, working memory and decision-making take a breather. Why Is the DMN Important Since the DMN was discovered, scientists have been working to better understand what it is, what it does, and why it's important. Though it's early days in understanding or even completely defining the DMN, the concept has already spawned some fascinating research. Some are focused on the role the DMN — and changes to its patterns — plays in dementia. Other research looks at the DMN in autism and certain types of psychosis. Some researchers are examining how addiction changes the DMN. The role of the DMN in post-traumatic stress disorder (PTSD) is yet another area of research. Perhaps one of the most interesting ideas about the DMN is that it plays a role in the construction of the self. The brain regions involved in autobiographical memory and ideas about the self are part of the DMN. Many of the ideas that float around the mind during this "downtime" have to do with our personal lives and our sense of who we are. So it's possible that when your brain isn't doing anything that seems important, it's actually quite busy making all the connections that make you feel like you. Read More: Study Suggests Brain Processes Information like Ocean Waves
 
 
 
Does Melatonin Cause Dementia?
 
 
 
 
The use of melatonin supplements has spiked significantly in the U.S. in recent years, prompting calls for more research into the effects of long-term melatonin supplementation in humans. That's because relatively little research has been done concerning how taking melatonin pills on a regular basis affects overall health. Particularly in aging populations with Alzheimer's or 
dementia
. Melatonin support has also been recommended for those who are blind and struggle with a regular sleep schedule. Synthetic versions of this hormone are frequently sold over the counter as a sleep aid, and research indicates that it likely impacts various aspects of health and wellness. The limited evidence available is also mixed on whether it benefits people who are struggling with sleep. A research letter published in JAMA last year drew attention to roughly a five-fold increase in people taking melatonin in the U.S. between 1999 and 2018. The findings by a team of researchers in Beijing and the Mayo Clinic in Rochester, Minnesota cited data from a National Health and Nutrition Examination Survey. They called for more research on this topic in the science community. Melatonin Melatonin is a natural hormone that our brains produce, generally increasing when we're exposed to the dark (at night) and decreasing during daylight. Thus, it plays a dynamic role in regulating sleep and circadian rhythms in humans and other mammals.  Melatonin and Sleep The physiological production of this hormone typically declines in someone as they age, which might impact sleep patterns. That's where oral supplements of melatonin offer potential promise and have been prescribed to populations with dementia and those struggling with sleep.  But the precise way that melatonin regulates sleep is not fully understood. For example, in its natural state, it doesn't have a sedating effect. In fact, in nocturnal animals, the natural chemical is active and associated with wakeful states rather than sleep.  Read More: The Importance of Sleep for Your Body Other Uses for Melatonin Beyond sleep, melatonin also has proven to be a potent immunomodulatory hormone and antioxidant, with properties that seem to reduce blood pressure, upregulate bone cell proliferation and inhibit bone resorption, according to a detailed review published early this year in Clinical Interventions in Aging. Is Melatonin Safe? Because of these many functions, and some adverse effects with melatonin in limited trials, that review suggested that "melatonin should thus be considered a medication, albeit a relatively safe one, rather than a harmless dietary supplement." The Mayo Clinic deems melatonin supplements as "generally safe" when treated as a sleeping pill and used under a doctor's supervision. But because the FDA defines the hormone as a dietary supplement, the product gets little oversight and regulation in the U.S., compared to over-the-counter medicine and prescription drugs.  Melatonin and Alzheimer's  Because both aging and dementia often impact the sleep cycle in aging populations, some have turned to melatonin to help treat symptoms of Alzheimer's and other fatal neurodegenerative diseases. In this arena, too, the results are mixed based on limited clinical trials. One of the major dilemmas is assessing the long-term effects and possible risks of taking supplemental melatonin with the potential immediate benefits of managing symptoms, such as insomnia. Read More: There's a New FDA-Approved Drug to Treat Alzheimer's Long Term Side Effects "Some studies have found neuroprotective effects of melatonin itself, but there are also concerns over the long-term health consequences of melatonin," says Yue Leng, an epidemiologist at the University of California San Francisco. Just this year, Leng published a study that compared the potential risk of dementia associated with various sleep medications based on the race of participants. Inadequate Evidence That work indicated that frequent use of sleep medications seems to be associated with an increased risk of dementia in white older adults. However, the scope of the research was unable to pinpoint any associations between dementia risk and melatonin specifically, due to the small sample of participants who reported using it.  "The effects of melatonin use on dementia risk is a controversial topic," Leng says. "More research is needed to examine both the short-term and long-term effects of melatonin on sleep and cognition in older adults." Read More: Understanding How Dementia Causes Death Does Melatonin Cause Dementia? Similarly, a 2016 Cochrane review identified a significant lack of evidence and research regarding sleep medication for people with dementia. Based on limited trials that have been done, the researchers in that review found no evidence that melatonin had a significant impact — adverse or beneficial — to those with dementia. They also found no significantly improved sleep in those who took melatonin. But this was based on limited data, with only four trials at the time involving 222 participants. Dementia and Sleep That same review found some evidence to support the use of a low dose of trazodone (prescription drug) to treat sleep issues in people with dementia, and no evidence for any effect of the sleeping pill ramelteon (prescription drug) on patients with mild to moderate Alzheimer's dementia. This was also based on limited evidence. The report ultimately concluded that much more research is needed in this field. "This is an area with a high need for pragmatic trials, particularly of those drugs that are in common clinical use for sleep problems in dementia," the researchers write. "Systematic assessment of adverse effects is essential." Read More: The 4 Main Types of Dementia
 
 
 
The Refreshing Spray of the Ocean Is Loaded With Sewage Bacteria, Scientists Find
 
 
 
Is this article about Tech & Scientific Innovation?
 
There's nothing like ocean spray gently caressing your face as you take a beachside stroll — quite literally, because it's actually full of bacteria. 
 
 

Grody Byproducts

There's nothing quite like ocean spray gently caressing your face as you take a beachside stroll. But unfortunately, your face may be getting battered with sewage bacteria in the process.

According to a new paper published in the journal Environmental Sciences & Technology, ocean spray samples from San Diego's Imperial Beach contained bacteria from sewage spillover — and those bacteria end up in the air people near the beach breathe, too.

There are real health risks associated with bacteria that come from sewage runoff as they are more likely to include pathogens such as E. Coli, salmonella, and the infamous, gastrointestinal issues-inducing norovirus.

It's still unclear, however, if bacteria found by the researchers are actually making people sick in the area.

"Are they potentially infectious? Some are pathogens and some are not," Prather told The Guardian. "That's something we're working on now."

Feel the Ocean

To put it plainly, this stuff is pretty gross — and it may be getting into the lungs of folks who live near coastal waters, especially those who swim in them.

"Once pollutants become airborne that just means so many more people can be exposed to those pollutants," explained Kim Prather, the principal investigator on the study out of UC San Diego's Scripps Institution of Oceanography, in an interview with the city's Union-Tribune newspaper. "It extends well beyond just people going to the beach or getting in the water."

Tijuana Syndrome

In their research, the team was able to link the bacteria to the Tijuana River just over the border in Mexico using air and water samples in and around the river and beach respectively.

They made a shocking discovery: the river sewage runoff could account for up to a whopping 76 percent of the bacteria at Imperial Beach.

While there's already an established body of work about airborne oceanic bacteria in general, this study is the first of its kind to establish a link to a known sewage source, UC San Diego professor and paper co-author Robert Knight told the Union-Tribune.

"It was a complete shock to find how much of microbes in the air were traceable back to sewage," Knight told the newspaper. "We had no idea that effect would be so strong."

With this seemingly strong link established in their research, the UCSD team plans to take DNA samples of lifeguards and surfers to see if they can gauge if there's a measurable impact to respiratory health as well.

"Now that we know this is a real phenomenon," Knight added, "we need to find out what are the impacts to human health."

More on gross byproducts: Residents Blame Horrid Black Fungus on Whiskey Facility

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Why Is Biden Attacking Democracy?
 
 
 
Feedly AI found 1 Regulatory Changes mention in this article
  • The bill is meant to streamline and update D.C.'s criminal code; the city council passed it unanimously, despite Mayor Muriel Bowser's opposition.
 

Give President Joe Biden democracy, self-rule, and statehood for Washington, D.C. But not yet.

Yesterday, Biden announced that he would not veto Congress's override of a new criminal code for D.C. passed by its city council. "I support D.C. Statehood and home-rule—but I don't support some of the changes D.C. Council put forward over the Mayor's objections—such as lowering penalties for carjackings," Biden tweeted. "If the Senate votes to overturn what D.C. Council did—I'll sign it."

If you support self-rule for jurisdictions only so long as they do not make choices you oppose, you do not actually support self-rule. The bill is meant to streamline and update D.C.'s criminal code; the city council passed it unanimously, despite Mayor Muriel Bowser's opposition. Bowser said she agreed with "95 percent" of the bill, excepting some of its lower maximum penalties for certain crimes and its expansion of jury trials to include misdemeanors, arguing that the latter would overburden the system.

[Anne Applebaum: A real place deserves real rights]

The changes to the city's criminal code are, as Slate's Mark Joseph Stern writes, much less dramatic than advertised. For example, the bill "lowers penalties for carjacking" in the sense that it changes the maximum sentence from a never-imposed 40 years to 24, which is still a very long time, and to which years can be added based on other potential offenses associated with the same crime. Some Senate Democrats are expected to vote to overturn the D.C. law, an indication of just how seriously they take their own rhetoric about democracy. One need not believe that the changes are a good idea to find this appalling. That's how democracy works: Sometimes the people make the wrong choice. The virtue of the system is that they make it, and it is not made for them.

Unfortunately, this is just the latest episode in a long history of the federal government's contempt for D.C.'s right to govern itself. In the 1870s, the city became a haven for the newly emancipated after the Civil War, and extended suffrage rights to all regardless of race. But as Reconstruction ended, the city became the fiefdom of outright white supremacists who plundered it for profit and exploited its Black residents. In 1890, the former Confederate general, plantation owner, and Democratic senator John Tyler Morgan of Alabama took to the Senate floor to explain why D.C. could not be allowed to govern its own affairs.  

Now, the historical fact is simply this, that the negroes came into this District from Virginia and Maryland and from other places; I know dozens of them here now who flocked in from Alabama … They came in here and they took possession of a certain part of the political power of this District. There was but one way to get out—so Congress thought, so this able committee thought—and that was to deny the right of suffrage entirely to every human being in the District and have every office here controlled by appointment instead of by election … in order to get rid of this load of negro suffrage that was flooded in upon them.

As the reporters Tom Sherwood and Harry Jaffe wrote in Dream City, their history of Washington, D.C., "It's impossible to dismiss the fact that raw discrimination against blacks was for years at the root of Congress's relationship with the District of Columbia."

Although the Constitution grants Congress power over the seat of government, the long-standing hostility toward the very idea of home rule in D.C. stems from the belief that Black people are incapable of governing themselves. In most cases, the rationales for denying representation to residents of the capital of a nation ostensibly founded on the idea that taxation without representation is tyranny have shifted to become more partisan than overtly racist, but some of them remain essentially Morganist. In 2009 Tucker Carlson said D.C. was not "ready for democracy," because it had elected Marion Barry as mayor. Barry was an extremely common American type—a corrupt ethnic-machine politician who was simultaneously an effective practitioner of patronage politics. But he was also Black; the alchemy of racism ensures that the flaws that transform Irish machine politicians into beloved and colorful characters turn Black machine politicians into proof of Black inferiority.

This argument, though, has persisted even as the city's Black majority has become a plurality: D.C. cannot be allowed to govern itself, because its voters might make decisions that its overlords do not like. In some states, legislators who could not count to 20 without taking off their shoes make a show of passing idiotic and cruel legislation that violates their constituents' most basic rights, but no one ever suggests that the voters who elected them be denied democratic self-determination as a result. The people of Washington, D.C., have no less a right to govern their own affairs than the people of Texas or Florida.

[Read: D.C. statehood is more urgent than ever]

Far from proving that D.C. cannot govern itself, Congress's interference with the city illustrates the necessity of D.C. statehood, even as it exposes the underlying reasons that the dream of statehood remains remote. Without real federal representation, there is no one to stand up for the city's interests in Congress, and those who make decisions about the District's affairs are accountable to constituents elsewhere, who have no reason to defend the city's interests or autonomy. The Republican commitment to "local control" is entirely superficial; I grew up in D.C. and live in Texas, and it is very clear to me that the principle applies only to GOP-run jurisdictions, which are mysteriously always deemed fit for self-governance.

The ease with which the Democratic supporters of D.C. statehood have been manipulated into parroting the arguments of pundits and politicians who support disenfranchisement is pathetic, but unsurprising: Because D.C. residents are disenfranchised, it costs Democrats nothing to look tough on crime by disregarding home rule. After all, what are DC residents going to do, send a Republican to the Senate?

D.C. deserves statehood because its residents, who outnumber those of Wyoming and Vermont, have their own political and cultural identity and have the same right as every other American to determine their own fate. The city's residents should be able to govern themselves without interference from politicians looking to burnish their reputations with their performative contempt for the people who actually live and work there.

To those who say that D.C. statehood is simply a matter of naked partisan interest (as if the opposition to it is not), I would say that is also the reason we have two Dakotas. It was only a month ago that the Biden administration put out a statement urging Congress to "respect the District of Columbia's autonomy to govern its own local affairs." Until D.C. has the shield of statehood and federal representation, neither party has any reason to listen.

 
 
 
Scientists Scan Great Pyramid, Discover Hidden Corridor
 
 
 
 
 
 

Tunnel Vision

Researchers have discovered a 30-feet-long unfinished corridor not far from the main entrance to the Great Pyramid of Giza in Egypt, Reuters reports — a breathtaking revelation, especially given the fact that we've been scanning the 4,500-year-old structure with infrared rays since 2015.

As detailed in a new article published in the journal Nature this week, the discovery made by the international research project Scan Pyramids could shed light on how the 479-foot-tall pyramid was constructed, and why the corridor is flanked by a massive limestone structure.

The corridor is only roughly 23 feet away from the pyramid's main entrance, which is crowded by tourists around the clock.

Most tantalizingly, we still don't know where the newly discovered tunnel even leads to.

"We're going to continue our scanning so we will see what we can do… to figure out what we can find out beneath it, or just by the end of this corridor," said Mostafa Waziri, head of Egypt's Supreme Council of Antiquities, as quoted by Reuters.

Pretty Stoned

Researchers believe the corridor may have been built to redistribute the pyramid's weight around the main entrance. It was discovered using a tiny endoscope, using cosmic-ray radiography.

Many questions remain about the corridor's purpose, though.

"There are two large limestones at the end chamber, and now the question is what's behind these stones and below the chamber," Christian Grosse, Professor of Non-destructive Testing at the Technical University of Munich, told NPR.

The news comes after a giant void almost 100 feet in length was discovered by Scan Pyramids researchers back in 2017, the largest to have been discovered in the ancient structure in over a century.

This latest discovery could potentially force us to reevaluate what we know about how the giant structure was constructed many thousands of years ago — something that scientists still don't fully agree on, and a fascinating puzzle given its immense size and the ancient technology its builders had to rely on.

READ MORE: Hidden corridor discovered in Great Pyramid of Giza [Reuters]

More on the pyramids: Scientists Discover Egyptian Secret to Making the Pyramids

The post Scientists Scan Great Pyramid, Discover Hidden Corridor appeared first on Futurism.

 
 
 
Scientists Discover That Toilet Paper Contains Toxic "Forever" Chemicals
 
 
 
 
Our toilet paper contains toxic "forever" chemicals that have been associated with troubling health problems — and the government doesn't know what to do.
 
 

Forever After

As if we needed more shit to deal with.

Published in the American Chemical Society's journal Environmental Science & Technology this week is a new study suggesting that the toilet paper we use is full of per- and polyfluoroalkyl substances (PFAS), toxic "forever" chemicals that don't break down in landfills and therefore, well, last forever.

In recent years, PFAS — which, along with TP, are also found in the coating of nonstick cookware, waterproof clothing, and in some cosmetic and cleaning products — have made headlines as scientists discover more about how harmful they can be for both humans and the environment.

As the Centers for Disease Control and Prevention note in an advisory, recent studies have linked high levels of PFAS consumption with increased cholesterol and blood pressure levels, increased risk of kidney or testicular cancer, decreased vaccine response in children, and more.

In fact, the Environmental Protection Agency is, per the Associated Press, considering issuing restrictions on them.

Toilet Paper USA

Bringing it back around to the TP of it all, this new study is adding more fuel to the anti-PFAS fire after researchers at the University of Florida found that a specific type of these forever chemicals, known as disubstituted polyfluoroalkyl phosphates (diPAPs), are uber-common in both wastewater and in toilet paper, strongly suggesting a link between the two.

In the US and Canada, the ACS journal paper notes, toilet paper appears to result in four percent of the diPAP contamination in wastewater sludge — and that number is even higher in Europe, where it contributes to 35 percent of the "forever" chemicals in Swedish wastewater and up to a whopping 89 percent in France.

While these findings are indeed troubling, the CDC and other regulatory bodies have warned that more research needs to be conducted to figure out both how serious PFAS contamination really is and how best to handle it.

Even the EPA's potential regulation will focus more on removing the chemicals from water than on banning their use completely — and that process alone, critics told the AP, could cost billions of dollars.

In the meantime, it's clear enough that these chemicals are bad news, and it's up to the industry to self-regulate while the government catches up — though as we've learned from Big Oil, that process can take even more time.

More on toxic chemicals: Locals Near Ohio Toxic Train Crash Say They're Experiencing Weird Symptoms

The post Scientists Discover That Toilet Paper Contains Toxic "Forever" Chemicals appeared first on Futurism.

 
 
 
 
 

Abstract

Secretory pathway Ca 2+ /Mn 2+ ATPase 1 (SPCA1) actively transports cytosolic Ca 2+ and Mn 2+ into the Golgi lumen, playing a crucial role in cellular calcium and manganese homeostasis. Detrimental mutations of the ATP2C1 gene encoding SPCA1 cause Hailey-Hailey disease. Here, using nanobody/megabody technologies, we determined cryo–electron microscopy structures of human SPCA1a in the ATP and Ca 2+ /Mn 2+ -bound (E1-ATP) state and the metal-free phosphorylated (E2P) state at 3.1- to 3.3-Å resolutions. The structures revealed that Ca 2+ and Mn 2+ share the same metal ion–binding pocket with similar but notably different coordination geometries in the transmembrane domain, corresponding to the second Ca 2+ -binding site in sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA). In the E1-ATP to E2P transition, SPCA1a undergoes similar domain rearrangements to those of SERCA. Meanwhile, SPCA1a shows larger conformational and positional flexibility of the second and sixth transmembrane helices, possibly explaining its wider metal ion specificity. These structural findings illuminate the unique mechanisms of SPCA1a-mediated Ca 2+ /Mn 2+ transport.
 
 
 
 
 

Abstract

Researchers working with administrative crime data often must classify offense narratives into a common scheme for analysis purposes. No comprehensive standard currently exists, nor is there a mapping tool to transform raw descriptions into offense types. This paper introduces a new schema, the Uniform Crime Classification Standard (UCCS), and the Text-based Offense Classification (TOC) tool to address these shortcomings. The UCCS schema draws from existing efforts, aiming to better reflect offense severity and improve type disambiguation. The TOC tool is a machine learning algorithm that uses a hierarchical, multilayer perceptron classification framework, built on 313,209 hand-coded offense descriptions from 24 states, to translate raw descriptions into UCCS codes. We test how variations in data processing and modeling approaches affect recall, precision, and F1 scores to assess their relative influence on model performance. The code scheme and classification tool are collaborations between Measures for Justice and the Criminal Justice Administrative Records System.
 
 
 
 
 

Abstract

The 1986 Chernobyl nuclear disaster initiated a series of catastrophic events resulting in long-term and widespread environmental contamination. We characterize the genetic structure of 302 dogs representing three free-roaming dog populations living within the power plant itself, as well as those 15 to 45 kilometers from the disaster site. Genome-wide profiles from Chernobyl, purebred and free-breeding dogs, worldwide reveal that the individuals from the power plant and Chernobyl City are genetically distinct, with the former displaying increased intrapopulation genetic similarity and differentiation. Analysis of shared ancestral genome segments highlights differences in the extent and timing of western breed introgression. Kinship analysis reveals 15 families, with the largest spanning all collection sites within the radioactive exclusion zone, reflecting migration of dogs between the power plant and Chernobyl City. This study presents the first characterization of a domestic species in Chernobyl, establishing their importance for genetic studies into the effects of exposure to long-term, low-dose ionizing radiation.
 
 
 
 
 

Abstract

Anticipating food crisis outbreaks is crucial to efficiently allocate emergency relief and reduce human suffering. However, existing predictive models rely on risk measures that are often delayed, outdated, or incomplete. Using the text of 11.2 million news articles focused on food-insecure countries and published between 1980 and 2020, we leverage recent advances in deep learning to extract high-frequency precursors to food crises that are both interpretable and validated by traditional risk indicators. We demonstrate that over the period from July 2009 to July 2020 and across 21 food-insecure countries, news indicators substantially improve the district-level predictions of food insecurity up to 12 months ahead relative to baseline models that do not include text information. These results could have profound implications on how humanitarian aid gets allocated and open previously unexplored avenues for machine learning to improve decision-making in data-scarce environments.
 
 
 
 
Is this article about Semiconductors?
 

Abstract

Iontronic pressure sensors are promising in robot haptics because they can achieve high sensing performance using nanoscale electric double layers (EDLs) for capacitive signal output. However, it is challenging to achieve both high sensitivity and high mechanical stability in these devices. Iontronic sensors need microstructures that offer subtly changeable EDL interfaces to boost sensitivity, while the microstructured interfaces are mechanically weak. Here, we embed isolated microstructured ionic gel (IMIG) in a hole array (28 × 28) of elastomeric matrix and cross-link the IMIGs laterally to achieve enhanced interfacial robustness without sacrificing sensitivity. The embedded configuration toughens and strengthens the skin by pinning cracks and by the elastic dissipation of the interhole structures. Furthermore, cross-talk between the sensing elements is suppressed by isolating the ionic materials and by designing a circuit with a compensation algorithm. We have demonstrated that the skin is potentially useful for robotic manipulation tasks and object recognition.
 
 
 
 
Is this article about Biopharma Industry?
 

Abstract

Catheter-associated urinary tract 
infections
 (CAUTIs) account for 40% of hospital-acquired infections (HAIs). As 20 to 50% of hospitalized patients receive catheters, CAUTIs are one of the most common HAIs, resulting in increased morbidity, mortality, and health care costs. Candida albicans is the second most common CAUTI uropathogen, yet relative to its bacterial counterparts, little is known about how fungal CAUTIs are established. Here, we show that the catheterized bladder environment induces Efg1- and fibrinogen (Fg)–dependent biofilm formation that results in CAUTI. In addition, we identify the adhesin Als1 as the critical fungal factor for C. albicans Fg-urine biofilm formation. Furthermore, we show that in the catheterized bladder, a dynamic and open system, both filamentation and attachment are required, but each by themselves are not sufficient for infection. Our study unveils the mechanisms required for fungal CAUTI establishment, which may aid in the development of future therapies to prevent these infections.
 
 
 
 
Is this article about Wellbeing?
 

Abstract

Social evolution is tightly linked to dispersal decisions, but the ecological and social factors selecting for philopatry or dispersal often remain obscure. Elucidating selection mechanisms underlying alternative life histories requires measurement of fitness effects in the wild. We report on a long-term field study of 496 individually marked cooperatively breeding fish, showing that philopatry is beneficial as it increases breeding tenure and lifetime reproductive success in both sexes. Dispersers predominantly join established groups and end up in smaller groups when they ascend to dominance. Life history trajectories are sex specific, with males growing faster, dying earlier, and dispersing more, whereas females more likely inherit a breeding position. Increased male dispersal does not seem to reflect an adaptive preference but rather sex-specific differences in intrasexual competition. Cooperative groups may thus be maintained because of inherent benefits of philopatry, of which females seem to get the greater share in social cichlids.
 
 
 
 
 

Abstract

While nitro and amino alkenes are common in pharmaceuticals, pesticides, and munitions, their environmental fates are not well known. Ozone is a ubiquitous atmospheric oxidant for alkenes, but the synergistic effects of nitrogen-containing groups on the reactions have not been measured. The kinetics and products of ozonolysis of a series of model compounds with different combinations of these functional groups have been measured in the condensed phase using stopped-flow and mass spectrometry methods. Rate constants span about six orders of magnitude with activation energies ranging from 4.3 to 28.2 kJ mol −1 . Vinyl nitro groups substantially decrease the reactivity, while amino groups have the opposite effect. The site of the initial ozone attack is highly structure dependent, consistent with local ionization energy calculations. The reaction of the neonicotinoid pesticide nitenpyram, which forms toxic -nitroso compounds, was consistent with model compounds, confirming the utility of model compounds for assessing environmental fates of these emerging contaminants.
 
 
 
 
 

Abstract

During cotranslational translocation, the signal peptide of a nascent chain binds Sec61 translocon to initiate protein transport through the endoplasmic reticulum (ER) membrane. Our cryo–electron microscopy structure of ribosome-Sec61 shows binding of an ordered heterotetrameric translocon-associated protein (TRAP) complex, in which TRAP-γ is anchored at two adjacent positions of 28 ribosomal RNA and interacts with ribosomal protein L38 and Sec61α/γ. Four transmembrane helices (TMHs) of TRAP-γ cluster with one C-terminal helix of each α, β, and δ subunits. The seven TMH bundle helps position a crescent-shaped trimeric TRAP-α/β/δ core in the ER lumen, facing the Sec61 channel. Further, our in vitro assay establishes the cyclotriazadisulfonamide derivative CK147 as a translocon inhibitor. A structure of ribosome-Sec61-CK147 reveals CK147 binding the channel and interacting with the plug helix from the lumenal side. The CK147 resistance mutations surround the inhibitor. These structures help in understanding the TRAP functions and provide a new Sec61 site for designing translocon inhibitors.
 
 
 
 
 

Abstract

Alternative precursor messenger RNA splicing is instrumental in expanding the proteome of higher eukaryotes, and changes in 3′ splice site (3'ss) usage contribute to human disease. We demonstrate by small interfering RNA–mediated knockdowns, followed by RNA sequencing, that many proteins first recruited to human C* spliceosomes, which catalyze step 2 of splicing, regulate alternative splicing, including the selection of alternatively spliced NAGNAG 3′ss. Cryo–electron microscopy and protein cross-linking reveal the molecular architecture of these proteins in C* spliceosomes, providing mechanistic and structural insights into how they influence 3'ss usage. They further elucidate the path of the 3′ region of the intron, allowing a structure-based model for how the C* spliceosome potentially scans for the proximal 3′ss. By combining biochemical and structural approaches with genome-wide functional analyses, our studies reveal widespread regulation of alternative 3′ss usage after step 1 of splicing and the likely mechanisms whereby C* proteins influence NAGNAG 3′ss choices.
 
 
 
 
Is this article about Biopharma Industry?
 

Abstract

Gene expression is changed by disease, but how these molecular responses arise and contribute to pathophysiology remains less understood. We discover that β-amyloid, a trigger of Alzheimer's disease (AD), promotes the formation of pathological CREB3L2-ATF4 transcription factor heterodimers in neurons. Through a multilevel approach based on AD datasets and a novel chemogenetic method that resolves the genomic binding profile of dimeric transcription factors (ChIPmera), we find that CREB3L2-ATF4 activates a transcription network that interacts with roughly half of the genes differentially expressed in AD, including subsets associated with β-amyloid and tau neuropathologies. CREB3L2-ATF4 activation drives tau hyperphosphorylation and secretion in neurons, in addition to misregulating the retromer, an endosomal complex linked to AD pathogenesis. We further provide evidence for increased heterodimer signaling in AD brain and identify dovitinib as a candidate molecule for normalizing β-amyloid–mediated transcriptional responses. The findings overall reveal differential transcription factor dimerization as a mechanism linking disease stimuli to the development of pathogenic cellular states.
 
 
 
 
Is this article about Cell?
 

Abstract

Bovine pericardium (BP) has been used as leaflets of prosthetic heart valves. The leaflets are sutured on metallic stents and can survive 400 million flaps (~10-year life span), unaffected by the suture holes. This flaw-insensitive fatigue resistance is unmatched by synthetic leaflets. We show that the endurance strength of BP under cyclic stretch is insensitive to cuts as long as 1 centimeter, about two orders of magnitude longer than that of a thermoplastic polyurethane (TPU). The flaw-insensitive fatigue resistance of BP results from the high strength of collagen fibers and soft matrix between them. When BP is stretched, the soft matrix enables a collagen fiber to transmit tension over a long length. The energy in the long length dissipates when the fiber breaks. We demonstrate that a BP leaflet greatly outperforms a TPU leaflet. It is hoped that these findings will aid the development of soft materials for flaw-insensitive fatigue resistance.
 
 
 
 
Is this article about Tech & Scientific Innovation?
 

Abstract

Gene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare 
cancer
 cells. However, we now demonstrate that chemoresistant neuroblastoma cells emerge at a much higher frequency when the influence of noise is integrated across multiple components of an apoptotic signaling network. Using a JNK activity biosensor with longitudinal high-content and in vivo intravital imaging, we identify a population of stochastic, JNK-impaired, chemoresistant cells that exist because of noise within this signaling network. Furthermore, we reveal that the memory of this initially random state is retained following chemotherapy treatment across a series of in vitro, in vivo, and patient models. Using matched PDX models established at diagnosis and relapse from individual patients, we show that HDAC inhibitor priming cannot erase the memory of this resistant state within relapsed 
neuroblastomas
 but improves response in the first-line setting by restoring drug-induced JNK activity within the chemoresistant population of treatment-naïve tumors.
 
 
 
 
 

Abstract

Small extracellular vesicles (sEVs) play a critical role in cardiac cell therapy by delivering molecular cargo and mediating cellular signaling. Among sEV cargo molecule types, microRNA (miRNA) is particularly potent and highly heterogeneous. However, not all miRNAs in sEV are beneficial. Two previous studies using computational modeling identified miR-192-5p and miR-432-5p as potentially deleterious in cardiac function and repair. Here, we show that knocking down miR-192-5p and miR-432-5p in cardiac c-kit cell (CPC)–derived sEVs enhances the therapeutic capabilities of sEVs in vitro and in a rat in vivo model of cardiac 
ischemia
 reperfusion. miR-192-5p– and miR-432-5p–depleted CPC-sEVs enhance cardiac function by reducing fibrosis and necrotic inflammatory responses. miR-192-5p–depleted CPC-sEVs also enhance mesenchymal stromal cell–like cell mobilization. Knocking down deleterious miRNAs from sEV could be a promising therapeutic strategy for treatment of chronic 
myocardial infarction
.
 
 
 
 
Is this article about Neuroscience?
 

Abstract

There is widespread concern about misinformation circulating on social media. In particular, many argue that the context of social media itself may make people susceptible to the influence of false claims. Here, we test that claim by asking whether simply considering sharing news on social media reduces the extent to which people discriminate truth from falsehood when judging accuracy. In a large online experiment examining coronavirus disease 2019 (COVID-19) and political news ( = 3157 Americans), we find support for this possibility. When judging the accuracy of headlines, participants were worse at discerning truth from falsehood if they both evaluated accuracy and indicated their sharing intentions, compared to just evaluating accuracy. These results suggest that people may be particularly vulnerable to believing false claims on social media, given that sharing is a core element of what makes social media "social."
 
 
 
Jonathan Majors Is Enjoying His Villain Era
 
 
 
 
 
On the precipice of his biggest year yet—with starring roles in Ant-Man and the Wasp: Quantumania and Creed III—Majors is finally at peace.
 
 
 
Livestock farming: Additive to make slurry more climate-friendly
 
 
 
Is this article about Sustainability?
 
Livestock farming produces large quantities of greenhouse gases, especially methane, which is particularly harmful to the climate. Among other things, it escapes during the storage of animal excrement, the slurry. A study now shows that methane emissions can be reduced by 99 percent through simple and inexpensive means. The method could make an important contribution to the fight against climate change.
 
 
 
They're Dumping $30 Million of Funko Pops Directly Into a Landfill
 
 
 
 
The company behind Funko Pop! collectibles, vastly over-estimated demand and is dumping $30 million worth of figurines in a landfill, Kotaku reports.
 
 
Funko

 Popped

As if having the planet drown in a giant pile of plastic pollution wasn't enough.

The company behind Funko Pop collectibles, those small figurines that vaguely represent celebrities and fictional characters and which you likely ignore at your local GameStop, vastly over-estimated demand and is dumping $30 million worth of figurines in a landfill, Kotaku reports.

Funko had a disastrous earnings call earlier this week, causing its stock price to crater on Thursday, dropping by a stunning 25 percent in after-hours trading on Wednesday.

The company announced that it was sitting on a massive pile of unsold inventory, which increased 48 percent year over year.

"This includes inventory that the Company intends to eliminate in the first half of 2023 to reduce fulfillment costs by managing inventory levels to align with the operating capacity of our distribution center," a press release reads. "This is expected to result in a write down in the first half of 2023 of approximately $30 to $36 million."

In other words, considering each Funko Pop figurine averages around $8 to $11, they're dumping millions of figurines into the garbage.

PVC Pollution

The company was already facing financial turmoil last year, with its distribution center in Arizona overflowing with inventory to the point it had to rent shipping containers to store them all.

By November, the venture's stock had already cratered after it slashed its financial outlook for the rest of the year, Kotaku reports.

While some Funko Pop models have propped up a considerable speculators' market — two recent golden figurines sold for $100,000 in cash — the reality is that their value is unlikely to last forever, damning them to slowly decompose in landfills.

The figurines are made of polyvinyl chloride, better known as PVC, a petroleum-derived chemical that's made using vinyl chloride — a substance that may sound familiar, because it was all over the news last month following the disastrous train derailment in East Palestine, Ohio, which released copious amounts of the stuff into the surrounding environment and waterways.

READ MORE: Over $30 Million Worth Of Funkos Are Headed To The Landfill [Kotaku]

More on plastic pollution: Chevron's Jet Fuel Made From Plastic Very Likely to Cause Cancer, EPA Documents Say

The post They're Dumping $30 Million of Funko Pops Directly Into a Landfill appeared first on Futurism.

 
 
 
Scientists find signs of horse riding in ancient human remains
 
 
 
 
A new study of ancient human remains finds that horse riding may have been common as early as 4,500 to 5,000 years ago.

Researchers have found evidence of horseback riding in skeletal remains of people who lived about 5,000 years ago, adding to a body of research on when people first started using horses to get around.

(Image credit: Alan Crowhurst/Getty Images)

 
 
 
There's Something Odd About the Dogs Living at Chernobyl
 
 
 
 

In the spring of 1986, in their rush to flee the radioactive plume and booming fire that burned after the Chernobyl power plant exploded, many people left behind their dogs. Most of those former pets died as radiation ripped through the region and emergency workers culled the animals they feared would ferry toxic atoms about. Some, though, survived. Those dogs trekked into the camps of liquidators to beg for scraps; they nosed into empty buildings and found safe places to sleep. In the 1,600-square-mile exclusion zone around the power plant, they encountered each other, and began to reproduce. "Dogs were there immediately after the disaster," says Gabriella Spatola, a geneticist at the National Institutes of Health and the University of South Carolina. And they have been there ever since.

 

Spatola and her colleagues are now puzzling through the genomes of those survivors' modern descendants. In identifying the genetic scars that today's animals may have inherited, the researchers hope to understand how, and how well, Chernobyl's canine populations have thrived. The findings could both reveal the lasting tolls of radiation and hint at traits that have helped certain dogs avoid the disaster's worst health effects. The fates of dogs—bred and adapted to work, play, and lounge at our side—are tied to ours. And the canines we leave behind when crises strike could show us what it takes to survive the fallout of our gravest mistakes.

 

One of the key canine groups the team is focusing on is based at what's left of the power plant itself, and has likely weathered the highest levels of radiation of any dog population in the exclusion zone. The researchers are working to compare the genomes of those dogs with those of others living farther out, in Chernobyl City, a quasi-residential region about nine miles away that was evacuated after the blast, and in Slavutych, a less contaminated city roughly 30 miles out, where many power-plant workers settled after leaving their post.

 

The spatial differences are essential to the study's success. The region's landscape is "a patchwork of different radioactivity levels," says Timothy Mousseau, a biologist at the University of South Carolina who's been studying Chernobyl's wildlife for more than 20 years, and is co-advising Spatola's work. Which means that geographically distinct packs of dogs could, in theory, have distinct exposure histories, and distinct genetic legacies to show for it. The team's work is just beginning. But in the hundreds of blood samples that Spatola and her colleagues have analyzed from dogs in all three groups, they've already found evidence that the reactor-adjacent canines are different in at least some ways.

 

The animals that the team sampled in Chernobyl City and Slavutych, the researchers found, look a lot like dogs you'd find elsewhere. They've been born of mixtures of modern breeds: mastiffs, pinschers, schnauzers, boxers, terriers. But the power-plant population seems more stuck in the past. The dogs there are far more inbred, and still skew heavily German shepherd—a breed that has a long history in the region, a hint that the animals have largely kept to their ancestral roots, says Elaine Ostrander, a geneticist at the National Institutes of Health and another of Spatola's co-advisers. This pack might represent something like "a time capsule" from the disaster's worst days, says Elinor Karlsson, a genomics expert at the Broad Institute of MIT and Harvard. Perhaps this lineage of dogs has been stewing in the plant's radiation for a dozen generations or more. Some may even have inherited mutations caused by the explosion itself.

 

The long-ranging consequences of their exposures, though, aren't yet clear. Repeated, heavy doses of radiation—which can mutate DNA, seed cancers, and irreparably damage the structural integrity of cells—can be, without question, "extremely detrimental to life," says Isain Zapata, a biomedical researcher at Rocky Vista University. And over the decades, a wealth of studies has revealed serious health effects among some local animalsBirds have been found with tumors and unusually small brainsbank voles have battled cataracts and produced wonky, underperforming sperm. Even bees seem to struggle to reproduce. Still, not all creatures are equally susceptible to radiation; many have also avoided the region's most saturated zones. And in some parts of the exclusion zone, some of them appear to be flourishing on terrain now largely devoid of humans and their polluting, disruptive ways. In this landscape of possibilities, it's hard to say where the dogs of Chernobyl might fall: Domestic canines depend heavily on us, and may suffer more than other animals when we leave. But that dependence also means that dogs are also less likely to chow down on wild, radiation-contaminated food, and may be well positioned to take advantage of the ruins we leave behind—and to mooch more when we start to creep back.

 

[Read: The creatures that remember Chernobyl]

 

What the team finds next will be telling. Scientists have already spent decades scrutinizing canine genomes; a reference book for what's "typical" already exists, which makes detecting "when something's unusual" much easier, Karlsson told me. The researchers might uncover mutations and sickness in the power-plant pack—a sign that the dogs' genomes have been walloped by years of radiation, as those of some other animals apparently have. But Karlsson also thinks the team could find the opposite: hints of genetic traits that have kept the dogs alive under harsh conditions, such as a higher resistance to cancer. That, in turn, could bode well for us. Canine and human genomes are quite similar, and "domestic dogs have been a model for human cancer for a very long time," says Shane Campbell-Staton, an evolutionary biologist at Princeton who studies Chernobyl's wolves. Perhaps these dogs did not bend under pressure, but instead thrived.

 

One of the trickiest parts of the project will be figuring out which differences among the studied dog groups are attributable to radiation, rather than the ways in which the Chernobyl disaster completely remodeled the region and its ecosystems. Populations of plants, insects, birds, and mammals ebbed and flowed, affecting the availability of resources and the presence of predators. Humans came and left, sometimes bringing food, medical care, or more dogs. Generations of animals replaced each other, and populations mingled and mixed. Olena Burdo, a radioecologist at the Kiev Institute for Nuclear Research, has worked for years to try to parse these many variables in her work with bank voles. In the wild, it's usually easy to tell that differences between populations exist, she told me. It's just not always possible to pinpoint why.

 

Without perfect record-keeping of individual canines, the team can't prove that the modern dogs they're sampling are directly descended from 1980s dogs, either. Burdo told me she suspects that at least some of the power-plant dogs may be more transient than the researchers think. If the three dog populations under study are loose, amorphous, and constantly turning over, the researchers will have a tough time determining the effects of higher- or lower-dose radiation exposure through generations. The power-plant dogs—the purported high-radiation cohort—may not really be a lineage born of the facility's buildings after all.

 

But Ostrander is fairly convinced that the power-plant population has largely kept to itself. Life among the abandoned buildings is actually quite plush. Workers toss the dogs leftovers; tourists cheerfully sneak them snacks. And in recent years, veterinarians have banded together to provide the dogs medical care, vaccinations, and spay-and-neuter services. Beyond that, the canines may not need much. The pack seems to have grown more aloof and self-sufficient over the years, Spatola told me, and may even be behaviorally reverting to some of its wilder, wolfish roots. Left to fend for themselves when the reactor blew, this population of dogs—which started out as pets—has been transformed, perhaps by radiation, perhaps by human fallibility, into something less familiar, more strange, and entirely its own.

 
 
 
The Vindication of Ask Jeeves
 
 
 
Feedly AI found 1 Mergers and Acquisitions mention in this article
  • He and his former business partner David Warthen eventually sold Ask Jeeves to Barry Diller and IAC for just under $2 billion.
 

 

It was a simpler time. A friend introduced us, pulling up a static yellow webpage using a shaky dial-up modem. A man stood forth, dressed in a dapper black pinstriped suit with a red-accented tie. He held one hand out, as if carrying an imaginary waiter's tray. He looked regal and confident and eminently at my service. "Have a Question?" he beckoned. "Just type it in and click Ask!" And ask, I did. Over and over.

 

With his steady hand, Jeeves helped me make sense of the tangled mess of the early, pre-Google internet. He wasn't perfect—plenty of context got lost between my inquiries and his responses. Still, my 11-year-old brain always delighted in the idea of a well-coiffed man chauffeuring me down the information superhighway. But things changed. Google arrived, with its clean design and almost magic ability to deliver exactly the answers I wanted. Jeeves and I grew apart. Eventually, in 2006, 

Ask Jeeves

 disappeared from the internet altogether and was replaced with the more generic Ask.com.

 

Many years later, it seems I owe Jeeves an apology: He had the right idea all along. Thanks to advances in artificial intelligence and the stunning popularity of generative-text tools such as ChatGPT, today's search-engine giants are making huge bets on AI search chatbots. In February, Microsoft revealed its Bing Chatbot, which has thrilled and frightened early users for its ability to scour the internet and answer questions (not always correctly) with convincingly human-sounding language. The same week, Google demoed Bard, the company's forthcoming attempt at an AI-powered chat-search product. But for all the hype, when I stare at these new chatbots, I can't help but see the faint reflection of my former besuited internet manservant. In a sense, Bing and Bard are finishing what Ask Jeeves started. What people want when they ask a question is for an all-knowing, machine-powered guide to confidently present them with the right answer in plain language, just as a reliable friend would.

[Read: AI search is a disaster]

With this in mind, I decided to go back to the source. More than a decade after parting ways, I found myself on the phone with one of the men behind the machine, getting as close to Asking Jeeves as is humanly possible. These days, Garrett Gruener, Ask Jeeves's co-creator, is a venture capitalist in the Bay Area. He and his former business partner David Warthen eventually sold Ask Jeeves to Barry Diller and IAC for just under $2 billion. Still, I wondered if Gruener had been unsettled by Jeeves's demise. Did he, like me, see the new chatbots as the final form of his original idea? Did he feel vindicated or haunted by the fact that his creation may have simply been born far too early?

 

The original conception for Jeeves, Gruener told me, was remarkably similar to what Microsoft and Google are trying to build today. As a student at UC San Diego in the mid-1970s, Gruener—a sci-fi aficionado—got an early glimpse of ARPANET, the pre-browser predecessor to the commercial internet, and fell in love. Just over a decade later, as the web grew and the beginnings of the internet came into view, Gruener realized that people would need a way to find things in the morass of semiconnected servers and networks. "It became clear that the web needed search but that mere mortals without computer-science degrees needed something easy, even conversational," he said. Inspired by Eliza, the famous chatbot designed by MIT's Joseph Weizenbaum, Gruener dreamed of a search engine that could converse with people using natural-language processing. Unfortunately, the technology wasn't sophisticated enough for Gruener to create his ideal conversational search bot.

 

So Gruener and Warthen tried a work-around. Their code allowed a user to write a statement in English, which was then matched to a preprogrammed vector, which Gruener explained to me as "a canonical snapshot of answers to what the engine thought you were trying to say." Essentially, they taught the machine to recognize certain words and provide really broad categorical answers. "If you were looking for population stats for a country, the query would see all your words and associated variables and go, Well, this Boolean search seems close, so it's probably this." Jeeves would provide the answer, and then you could clarify whether it worked or not.

 

"We tried to discern what people were trying to say in search, but without actually doing the natural-recognition part of it," Gruener said. After some brainstorming, they realized that they were essentially building a butler. One of Gruener's friends mocked up a drawing of the friendly servant, and Jeeves was born.

 

Pre-Google, Ask Jeeves exploded in popularity, largely because it allowed people to talk with their search engine like a person. Within just two years, the site was handling more than 1 million queries a day. A massive Jeeves balloon floated down Central Park West during Macy's 1999 Thanksgiving parade. But not long after the butler achieved buoyancy, the site started to lose ground in the search wars. Google's web-crawling superiority led to hard times for Ask Jeeves. "None of us were very concerned about monetization in the beginning," Gruener told me. "Everyone in search early on realized, if you got this right, you'd essentially be in the position of being the oracle. If you could be the company to go to in order to ask questions online, you're going to be paid handsomely."

[Read: The open secret of Google Search]

Gruener isn't bitter about losing out to Google. "If anything, I'm really proud of our Jeeves," he told me. Listening to Gruener explain the history, it's not hard to see why. In the mid-2000s, Google began to pivot search away from offering only 10 blue links to images, news, maps, and shopping. Eventually, the company began to fulfill parts of the Jeeves promise of answering questions with answer boxes. One way to look at the evolution of big search engines in the 21st century is that all companies are trying their best to create their own intuitive search butlers. Gruener told me that Ask Jeeves's master plan had two phases, though the company was sold before it could tackle the second. Gruener had hoped that, eventually, Jeeves could act as a digital concierge for users. He'd hoped to employ the same vector technology to get people to ask questions and allow Jeeves to make educated guesses and help users complete all kinds of tasks. "If you look at Amazon's Alexa, they're essentially using the same approach we designed for Jeeves, just with voice," Gruener said. Yesterday's butler has been rebranded as today's virtual assistant, and the technology is ubiquitous in many of our home devices and phones. "We were right for the consumer back then, and maybe we'd be right now. But at some point the consumer evolved," he said.

 

I've been fixated on what might've been if Gruener's vision had come about now. We might all be Jeevesing about the internet for answers to our mundane questions. Perhaps our Jeevesmail inboxes would be overflowing and we'd be getting turn-by-turn directions from an Oxford-educated man with a stiff English accent. Perhaps we'd all be much better off.

 

Gruener told me about an encounter he'd had during the search wars with one of Google's founders at a TED conference (he wouldn't specify which of the two). "I told him that we're going to learn an enormous amount about the people who are using our platforms, especially as they become more conversational. And I said that it was a potentially dangerous position," he said. "But he didn't seem very receptive to my concerns."

 

Near the end of our call, I offered an apology for deserting Jeeves like everyone else did. Gruener just laughed. "I find this future fascinating and, if I'm honest, a little validating," he said. "It's like, ultimately, as the tech has come around, the big guys have come around to what we were trying to do."

 

 

 

 
 
 
Is Bill Nye the Science Guy Really a Scientist?
 
 
 
 
In the spring of 1993, a 30-minute program called Bill Nye the Science Guy aired for the first time on KCTS-TV, a Seattle-based PBS affiliate. Within months, the show was being syndicated nationally, and what followed was life-changing for the show's titular host: six seasons, 100 episodes and substantial underwriting from the National Science Foundation and the U.S. Department of Energy. Bill Nye was suddenly famous — broadcast into the homes and schools of millions of children, to explain science in entertaining terms they could understand. His program won 19 Emmy Awards, spawned a video game and made him a household name in television-based science programming for decades to come. But is Bill Nye a scientist? Or, as his classic PBS show suggests, is he just a "science guy?" Young Bill Nye Nye was born in Washington D.C., in 1955, to parents with incredible World War II military stories. His mother, Jacqueline Jenkins, was a Navy codebreaker. His father, Edwin Nye, was an airstrip contractor who spent four years in a Japanese prisoner-of-war camp. Bill Nye's Education Fascinated simply by how things worked, Nye later attended Cornell University's Sibley School of Mechanical and Aerospace Engineering — graduating with a degree in mechanical engineering in 1977. He even took an astronomy course taught by Carl Sagan. After college, Nye was hired by Boeing and moved to the Seattle area. There, he invented a hydraulic resonance suppressor tube for the 747's horizontal stabilizer drive system. He also set his sights on the heavens, though unsuccessfully; he applied to NASA's astronaut program four times. Read More: 4 Things We Have Thanks to Carl Sagan When Did Bill Nye the Science Guy Start? Nye's path to being on television actually began with stand-up comedy, which he began doing after winning a Steve Martin look-alike contest in 1978. After splitting his days and nights between engineering and comedy for several years, Nye finally quit his job at Boeing to pursue comedy full-time in 1986. TV Persona He soon befriended comedians Ross Shafer and John Keister, who were both part of a new, half-hour sketch show on KING-TV called Almost Live. Nye became a writer and cast member for the show, where he worked until 1991. It's worth noting that he was also a volunteer "science explainer" at Seattle's Pacific Science Center during this time. It was on Almost Live that his "science guy" persona first graced the airwaves, with Nye doing classic science demonstrations while dressed in a lab coat and safety glasses. Audiences loved it — and he even won an Emmy from the Seattle chapter of the National Academy of Television Arts and Sciences. What Did Bill Nye Do? Though new episodes of the beloved PBS show quit airing in 1999, Nye has kept plenty busy as an ambassador for scientific learning. He's written eight children's books for elementary and middle school students, as well as three books for general audiences. He also publicly debated creationist Ken Ham in 2014, in a widely-publicized discussion of evolution versus creationism. On the air, Nye presented a season of The Eyes of Nye (a more adult science-based program) on KCTS in 2005, and three seasons of Netflix's Bill Nye Saves the World from 2016 to 2018. His latest program, Peacock's The End is Nye, focuses on human-made and natural calamities that could destroy civilization and how they can be mitigated. But even when a camera lens is absent, Nye has remained busy. Bill Nye the Scientist Nye helped develop the MarsDial — a sundial that was included on the Opportunity and Spirit Mars rovers. He was also vice president of the Planetary Society, the world's largest space interest group, from 2005 to 2010, and is currently its executive director. As for other organizations, Nye is a member of the Committee for Skeptical Inquiry, a non-profit that promotes scientific inquiry and critically reasoned investigation of claims, and an advisory council member of the National Center for Science Education. Additionally, Bill Nye holds patents as an inventor, including an improved toe shoe for ballerinas, a device to easily pick up a baseball, a water-based magnifier and a digital abacus that does math with only binary numbers. Read More: 5 Inventions That Were Discovered by Accident So, Is Bill Nye a Real Scientist? While Nye is absolutely an engineer, the Science Council defines a scientist as "someone who systematically gathers and uses research and evidence, to make hypotheses and test them, to gain and share understanding and knowledge." Systematic Approach They can be further defined, the council says, by how they get their information (i.e., statistics or data scientists), what they're trying to understand (i.e., an astronomer seeking to understand the stars) or where they apply their science (i.e., a food scientist working in the food industry). But all scientists, the Science Council concludes, are united by a "relentless curiosity and systematic approach to assuaging it." Though Nye may have spent more time on television than in formal lab settings, it would be hard to deny his legitimacy as a scientist — especially after taking into consideration all that he's accomplished and the profound influence he's had on a generation of younger scientists. Read More: The 10 Greatest Scientists of All Time
 
 
 
What Happens When Anxiety Turns to Anger
 
 
 
Is this article about Sleep?
 
It was a familiar scene in my office, where I practice as a clinical psychiatrist. The well-dressed woman sat across from me with a worried furrow between her brows. "Doctor, my husband and children say I get too angry," she said. "I have trouble controlling my temper. Do you think I have bipolar disorder?"  After a thorough evaluation, I concluded that my patient's verbal outbursts and tendency to throw dishes didn't stem from a severe mood disorder, but from uncontrollable anxiety. My patient was surprised. Perhaps you are, too.  Read More: What is Anxiety and How Can Worries Overpower Us? Anxiety has soared since the onset of the COVID-19 pandemic, with at least 40 million U.S. adults currently affected by at least one anxiety disorder, according to the Anxiety and Depression Association of America. As such, it's more important than ever to recognize possible consequences of these issues, and the possible causes behind them. One of the most misunderstood relationships is between anxiety and angry outbursts.  Understanding Anxiety Disorders Anxiety disorders come in different shapes and sizes. Nonetheless, all of the examples below can produce enough fear and angst to interfere with the sufferer's daily quality of life. Social anxiety disorder, sometimes called SAD, refers to fear of negative evaluation by others in social or performance situations. Obsessive-compulsive disorder, or OCD, features debilitating thoughts "running in a loop" that lead to unwanted repetitive actions. Generalized anxiety disorder is the tendency to worry uncontrollably about usual and common life circumstances. Panic disorder is felt in the body with symptoms like shortness of breath and a fast heartbeat.  When Anxiety Leads to Anger It's tempting to think of anxiety and anger as the opposite ends of a spectrum — that is, people who are fearful are anything but aggressive. But having an anxiety problem can actually increase the likelihood of angry outbursts. Both anger and anxiety involve some sort of emotional dysregulation and a perceived threat, according to psychiatrist Franklin Schneier, co-director of the Anxiety Disorders Clinic at New York State Psychiatric Institute. That threat activates a part of the brain called the amygdala, which serves as a center that processes both fearful and threatening stimuli. The result? "It's the classic fight or flight dilemma," says Schneier.    Read More: OCD, PTSD, Generalized Anxiety Disorder and More: What's the Difference? It seems logical that those with anxiety disorders would choose "flight," or avoidance of the threatening situation. But this isn't always the case. The presence of a threat is just as likely to produce irritability — or aggression. In fact, the bond between anxiety and anger can be so tight that it feels fitting to call the combination "anxry," like the informal word "hangry" used for anger as a result of being hungry.  But while fear and anger can be closely related, they are not the same emotion. Although anger can sometimes lead to anxiety, our focus here is on the opposite, where fear is the underlying emotion and aggression is the behavior.   Why Anxiety Can Lead to Anger Research backs up the claim that anxiety can lead to anger. Jesse Cougle, a professor of psychology at Florida State University, and his team studied the frequency of aggression across several different anxiety disorders, according to research published in the journal Depression and Anxiety. The researchers found elevated anger levels across all anxiety disorders.  There are several possible reasons for this link. For one, the very experience of anxiety is a type of emotional arousal that can be distressing. In other words, people with anxiety might have a tendency to overreact in general. "When someone cuts them off in traffic or when there's a perceived slight or an inconvenience — these can lead to anger because they're already in a distressed and aroused state," says Cougle.      Another possible cause might include the temptation to push aside the anxious feelings.  "When you avoid feelings you don't deal with them so well. Just avoiding anxiety — not acknowledging it because it's too scary — can result in the anger building up until it's uncontrollable and it explodes," says Schneier.    Read More: If Humans Are Social Creatures, Why Did Social Anxiety Evolve?  Take social anxiety. Those with SAD tend to avoid conflict and might go out of their way to appease others. But they also expect others to act in a negative way towards them. Feelings of rejection can lead to irritability or behaviors that are aggressive — the exact opposite of the timidity that one might expect of someone with social anxiety. For example, if you put a socially anxious teen in a setting where they can't judge another's intentions — like a high school dance — and when the teen returns home she lashes out at her parents for forcing her to go.   Another overlooked link between anxiety and anger involves lack of sleep.  People with anxiety disorders have difficulty falling and staying asleep. Overtime, this pent up fatigue can lead to an irritable outburst.   How to Treat Anxiety and Anger A 2021 study from researchers at Florida State University showed that reducing anxiety can have a beneficial effect on anger reduction. But which types of treatments work best?  One first line of defense is to be aware of negative emotions. It's important for the "anxry" sufferer to be aware of their thoughts — particularly spiraling, catastrophic thoughts. This is where cognitive-behavioral therapy (CBT) comes in. The therapist can help the patient view thoughts differently and adjust their behavior. "CBT approaches are useful for self-monitoring of anxious and angry thoughts and impulses," says Schneier. "[It's about] using the anger as information to either address the underlying conflict or calm oneself so it doesn't get out of hand."     Read More: Anxiety and Depression Relief, No Therapist Required Because people with "anxry" are more likely to drop out of treatment than those with anxiety alone, in some cases treatment should target both halves of the equation.  "We have treatments that are not focused on a single diagnosis. […] They are trying to reduce things like 'negative affectivity,' a broad construct that both anger and anxiety have in common," adds Cougle. "Mindful emotional awareness" (or, simply, the practice of mindfulness) is one of these therapies. This refers to the ability to feel the first signs of anger or anxiety in our body, and accept those feelings without judgement.   Of course anger is associated with many other disorders including depression, bipolar disorder and borderline personality disorder, to name a few. Teasing out underlying anxiety can be difficult — both for the sufferer caught in the heat of the moment, and for their loved ones. The consequences of "anxry" are often frightening, so seeking professional diagnosis and treatment can bring much needed relief.   
 
 
 
5 Times Radioactive Items Went Missing
 
 
 
 
Radioactive materials, also known as radionuclides, are chemicals in which the atom is unstable. As atoms try to restore balance, they break down and decay-causing the release of energy, known as radiation. Small amounts of radiation are all around us, including in everyday products such as microwaves and smoke detectors. Other uses include killing germs in food as well as helping diagnose and treat certain medical conditions. However, exposure to large amounts of radiation (by inhalation, absorption or ingestion) can be extremely harmful. Potentially dangerous radioactive material "goes missing" about 100 times a year worldwide. It might be lost or stolen. 1. Iridium-192: Michigan (2023) An inspection company in Ohio that does testing in the industrial and energy fields shipped Iridium-192 to a facility in Michigan. Almost 10 days later, the package had not yet arrived. While the material was radioactive, the inspection company assured the public that they used shipping safety precautions, that included secure and protective packaging. Someone would have needed to break open the container to access the radioactive material if found. A little over a week later, the package was located, and the public was assured it had always been within the carrier's control. 2. Dirty Bomb Material: Malaysia (2018) In 2018, the materials for a "dirty bomb" disappeared from the back of a pickup truck while being transported in Malaysia near Kuala Lumpur. The missing device was an industrial radiography unit used to locate cracks within metal. It was housed in a large metal tube that weighed 50 pounds. This was another case involving Iridium-192. In this situation, it was an undisclosed amount. Still, it was troubling, as the unknown amount of this radioactive isotope could cause harm within minutes to hours if handled. Iridium-192 could have fatal effects on someone within close exposure for hours to days. Unfortunately, the material was never found. 3. Soil Gauge: Alabama (2023) a Geotech engineering firm employee left behind or lost a device used to measure soil density and moisture. The Alabama Department of Public Health released a public statement asking for help locating the radioactive device and offered a reward.  The gauge was securely locked in a box, clearly labeled as radioactive materials, but the public was warned not to touch it. A member of the public found the device and returned it to its rightful owner. And neither the company nor the government disclosed the specific materials contained in the gauge. Read More: The Mysterious Radiation Bursts Threatening Aircrew 4. Plutonium and Cesium: Texas (2017) Two employees from Idaho's Department of Energy's National Lab picked up nuclear materials from a research lab in Texas. They brought radiation detectors and small amounts of plutonium and cesium to confirm they were retrieving the correct items. When the employees spent the night at a hotel along the way back, they (inexplicably) left the suitcases containing the sensors and the radioactive materials in their truck. The following day, they found the window smashed and the suitcases stolen. The event was not disclosed to the public by authorities. Nobody has been arrested for the theft, and the items have not been recovered. 5. Radioactive Capsule: Australia (2023) When a truck carrying a pea-sized radioactive capsule containing caesium-137 (cesium-137) arrived at a storage facility in Perth, Australia — the capsule was missing. The capsule was used for a density gauge in the mining industry. It's believed that the hardware holding the gauge together loosened during travel, and the capsule first fell out of the gauge — and then fell out of a space in the truck. The capsule was located by authorities who searched a stretch of highway almost 900 miles long. Found among pebbles about seven feet from the road, the capsule was verified using the serial number printed on it.
 
 
 
 
Is this article about Tech & Scientific Innovation?
 
Modifying inflorescences with higher grain capacity is vital for crop grain production. One recurring target is to select inflorescences with more branches or floral structures. Prominent examples include genes affecting floral identity or meristem determinacy, for which natural or induced variants profoundly change floral primordium number. Yet for temperate cereal crops, such as wheat and barley, excessive floral structures can result in a degeneration penalty due to the indeterminate nature of meristems. On the other hand, the manifestation of this reproductive potential can be accentuated by environmental fluctuations such as light, temperature and nutrition. Increasing the fraction of surviving florets/spikelets may thus improve grain yield in cereals.
 
 
 
 
Is this article about Tech & Scientific Innovation?
 
Modifying inflorescences with higher grain capacity is vital for crop grain production. One recurring target is to select inflorescences with more branches or floral structures. Prominent examples include genes affecting floral identity or meristem determinacy, for which natural or induced variants profoundly change floral primordium number. Yet for temperate cereal crops, such as wheat and barley, excessive floral structures can result in a degeneration penalty due to the indeterminate nature of meristems. On the other hand, the manifestation of this reproductive potential can be accentuated by environmental fluctuations such as light, temperature and nutrition. Increasing the fraction of surviving florets/spikelets may thus improve grain yield in cereals.
 
 
 
 
Is this article about Ecosystem Management?
 
Oil palm trees are the most productive oil crop and global demand is increasing. However, their productivity is due to conventional management practices including high fertilizer usage and herbicide application, resulting in severe environmental damage.
 
 
 
Developing nanoprobes to detect neurotransmitters in the brain
 
 
 
Is this article about Cell?
 
The animal brain consists of tens of billions of neurons or nerve cells that perform complex tasks like processing emotions, learning, and making judgments by communicating with each other via neurotransmitters. These small signaling molecules diffuse—move from high to low concentration regions—between neurons, acting as chemical messengers.
 
 
 
 
 
Though wildlife trafficking has been effectively disrupted since the first World Wildlife Day — established 50 years ago today via the 1973 Convention on International Trade in Endangered Species (CITES) of Wild Fauna and Flora — a newly published case study on one of the world's rarest tortoise species, the ploughshare tortoise, highlights how much room for improvement still exists.
 
 
 
Developing nanoprobes to detect neurotransmitters in the brain
 
 
 
 
Neurons perform numerous complex tasks by communicating with each other via small messenger molecules called neurotransmitters. Accurately detecting them is crucial to understanding the functioning of our brain. To this end, researchers have demonstrated that fluorescent nanoparticles imprinted with the molecular structure of a target neurotransmitter, immobilized on glass beads at a controlled surface density, can detect specific neurotransmitters based on their expansion during interaction with the target transmitters.
 
 
 
Fluorescent protein sheds light on bee brains
 
 
 
 
An international team of bee researchers has integrated a calcium sensor into honey bees to enable the study of neural information processing including response to odors. This also provides insights into how social behavior is located in the brain.
 
 
 
CNET's Post-AI Layoffs Apparently Gutted 50 Percent of Its News and Video Staff
 
 
 
Feedly AI found 1 Leadership Changes mention in this article
  • Remember, CNET's editor-in-chief Connie Guglielmo — who in a grim punchline is stepping down to become the company's VP of AI content strategy — defended the tech after a public outcry as a bid to free up journalists to do more interesting work.
 
Internal correspondence obtained Futurism alleges that CNET has gutted 50 percent of its news and video staff in its recent layoffs.
 
 

The full scope of CNET's layoffs after its disastrous foray into AI-powered journalism is coming further into focus — and frankly, things don't look too good.

According to internal correspondence Futurism obtainedCNET — which has maintained that the job cuts have absolutely nothing to do with their misfired AI, actually — gutted 50 percent of its news and video staff in the most recent culling.

That's a striking number, especially in light of the fact that CNET's owner, Red Ventures, very much appears like it's planning to start up its mystery AI machine once again.

Remember, CNET's editor-in-chief Connie Guglielmo — who in a grim punchline is stepping down to become the company's VP of AI content strategy — defended the tech after a public outcry as a bid to free up journalists to do more interesting work.

"The goal: to see if the tech can help our busy staff of reporters and editors with their job to cover topics from a 360-degree perspective," she wrote in January. "Will this AI engine efficiently assist them in using publicly available facts to create the most helpful content so our audience can make better decisions? Will this enable them to create even more deeply researched stories, analyses, features, testing and advice work we're known for?"

That clearly didn't work out so well, with the site's news operation now cut off at the knees. In an email to FuturismCNET neither confirmed nor denied the 50 percent figure.

"Out of respect of those leaving the CNET Group," a CNET spokesperson wrote in an email, "we will not be sharing specific details of yesterday's reorganization."

And according to a source familiar with the matter, CNET isn't the only Red Ventures publication to be hit with massive editorial layoffs. ZDNET, another Red Ventures-owned tech outlet, lost 35 percent of its editorial staff. And to that end, we wouldn't be surprised to learn that Red Ventures were rolling its editorial AI system out over at ZDNET, too.

Again, though, leaders at CNET and Red Ventures are chalking the layoffs up to reorganization. Their simultaneously ongoing AI saga, they say, is just a coincidence.

"Today's decision," a CNET spokesperson told Variety, "was not a reflection of the value or performance of our team members, the use of emerging technologies, or our confidence in the CNET Group's future."

In other words: "AI who?"

"To prepare ourselves for a strong future, we will need to focus on how we simplify our operations and our tech stack," Carlos Angrisano, president of financial services and the CNET Group at Red Ventures, wrote in a Thursday morning email to CNET staff, according to a report from The Verge, "and also on how we invest our time and energy."

Per the Verge, Angrisano's email additionally noted that the reorganization was part of a broader effort to focus on "consumer technology, home and wellness, energy, broadband, and personal finance" — indeed, an effort that CNET echoed in their statement to us, explaining that such are "categories where the CNET Group has a high degree of authority, relevance, differentiation and where we can make a large difference in the lives of our audience."

"We believe success in these focus areas will set the groundwork for future expansion," the statement continued, "and create the right conditions for a high-growth, sustainable business."

According to a current staffer, that makes perfect sense. Those content categories, they told the Verge, are where the SEO-hound that is Red Ventures is likely to bring in the most affiliate-link cash — even if the quality of the work suffers.

"But those sections are shadows of what they once were, particularly home," said the staffer, per the report. "If you want to do that section the right way, you don't sell off your Smart Home, get rid of its video team and cripple your editorial staff."

And as for "making a large difference in the lives" of its audience, let's hope that the information that CNET is publishing is actually right this time — otherwise, while the difference that the company makes is still bound to be a big one, it's also bound to be a bad one.

At the end of the day, we understand that everyone's got a bottom line. But there's a difference between bottom lines and rock bottoms, and if you have to stoop this far to ensure that your bottom line is taken care of, it's worth wondering if the road taken was worth it.

More on CNET cuts: CNET Says It's a Total Coincidence It's Laying off Humans after Publishing AI-Generated Articles

The post CNET's Post-AI Layoffs Apparently Gutted 50 Percent of Its News and Video Staff appeared first on Futurism.

 
 
 
Gen Z Is Apparently Baffled by Basic Technology
 
 
 
Is this article about Education?
 
Gen Z workers are entering the workforce with plenty of technological know-how, but plenty of glaring gaps as well, making navigating office life difficult.
 
 

Members of Gen Z are entering the workforce with certain types of technological know-how, from navigating the depths of the internet and using apps to editing photos on their smartphones.

But when it comes to using a scanner or printer — or even a file system on a computer — things become a lot more challenging to a generation that has spent much of their lives online, The Guardian reports, a counterintuitive result of workplaces still relying on technologies that were around long before they were born.

"There is a myth that kids were born into an information age, and that this all comes intuitively to them," Sarah Dexter, an associate professor of education at the University of Virginia, told the newspaper. "But that is not realistic. How would they know how to scan something if they've never been taught how to do it?"

For instance, 25-year-old New Yorker Garrett Bemiller admitted to The Guardian that he was stumped by a photocopy machine at his office.

"It kept coming out as a blank page, and took me a couple times to realize that I had to place the paper upside-down in the machine for it to work," he said.

Educators have already found that the latest generation of students is struggling with wrapping their minds around the concept of file folders and directories. Even astrophysics students had a hard time with the concept, as The Verge reported back in 2021.

After all, why dig around for a while when you can just use your computer's search functions? A quick Google search can easily get you to the answer you are looking for in a fraction of a second.

It's become such a commonplace discussion these days that tech company HP went as far as to give the phenomenon a name: "tech shame."

HP found that young people are ten times more likely to feel "tech shame" as compared to older colleagues, according to a November survey, the result of a basic misjudgment.

"The assumption is that because Gen Z and even millennials spend a considerable amount of time on technology that they are technology savvy," Debbie Irish, HP's head of UK and Ireland human resources, told WorkLife last year. "This is a huge misconception. Sadly, neither watching TikTok videos nor playing Minecraft fulfills the technology brief."

There's plenty of evidence that 

Gen Zers

 don't feel adequately prepared for office life. Last year, a LaSalle Network survey found recent graduates simply didn't possess the technical skills to successfully enter the workforce.

Then there's social media, which has set a high bar for accessibility.

"It takes five seconds to learn how to use TikTok," content creator Max Simon, who makes TikTok videos about corporate life, told The Guardian. "You don't need an instruction book, like you would with a printer."

"Content is so easy to access now that when you throw someone a simple curveball they'll swing and they miss," he added, "and that's why Gen Z can't schedule a meeting."

But for tech-savvy Gen Zers, the situation is quite different. They're still far more adaptable than their older colleagues and will frequently be tapped for help themselves.

That kind of trial and error and Google-assisted problem-solving has long gone over the heads of the older generations, which will only deepen the divide.

Besides, why are we still using scanners and printers in the year 2023? Perhaps employers should finally get with the times and say goodbye to that ancient tech.

READ MORE: 'Scanners are complicated': why Gen Z faces workplace 'tech shame' [The Guardian]

More on Gen Z: Gen Z Kids Apparently Don't Understand How File Systems Don't Work

The post Gen Z Is Apparently Baffled by Basic Technology appeared first on Futurism.

 
 
 
The world's first horse riders found near the Black Sea
 
 
 
Is this article about Animals?
 
Researchers have discovered evidence of horse riding by studying the remains of human skeletons found in burial mounds called kurgans, which were between 4,500 and 5,000 years old. The earthen burial mounds belonged to the Yamnaya culture. The Yamnayans had migrated from the Pontic-Caspian steppes to find greener pastures in today´s countries of Romania and Bulgaria up to Hungary and Serbia.
 
 
 
 
Is this article about Energy?
 
Livestock farming produces large quantities of greenhouse gases, especially methane, which is particularly harmful to the climate. Among other things, it escapes during the storage of animal excrement, the slurry. A study by the University of Bonn now shows that methane emissions can be reduced by 99% through simple and inexpensive means. The method could make an important contribution to the fight against climate change. The results have now been published in the journal Waste Management.
 
 
 
 
Is this article about Energy?
 
Livestock farming produces large quantities of greenhouse gases, especially methane, which is particularly harmful to the climate. Among other things, it escapes during the storage of animal excrement, the slurry. A study by the University of Bonn now shows that methane emissions can be reduced by 99% through simple and inexpensive means. The method could make an important contribution to the fight against climate change. The results have now been published in the journal Waste Management.
 
 
 
YouTubers Make 43-Inch Gaming Laptop Using Intel NUC, Plywood
 
 
 
 
 
 

Laptop manufacturers have focused on making systems thinner over the years. A pair of DIY YouTubers became unhappy with that trend and decided to go in the opposite direction. Just for fun and to see what it would look like, they built a monstrous 43-inch gaming laptop from scratch. The finished product looks like you'd expect a gaming laptop to look with LED lighting and a huge display. However, it's not the most practical computer, weighing 100 pounds.

The heart of the laptop is a 43-inch TV that was screwed into a plywood frame via its VESA mount. That type of wood was also used for the computer's base and is what makes the thing so darn heavy. Aluminum "arms" along the edges connect to custom-made hinges to allow it to open and close. The notebook shell is two inches deep, which was the primary limitation on what hardware could power it. The display also needed a power source, so they outfitted it with three batteries: one runs the display, one powers the computer, and the third is for the LEDs.

With the shell constructed, they did a dry run to see if it would boot and offer enough power to run games. Surprisingly, the portable batteries worked fine, with the host saying the system consumes around 260W under full load. Powering the monstrosity is an 

Intel

 NUC 11, according to HotHardware. This mini PC features a quad-core Intel Core i7-1165G7 Tiger Lake processor and an RTX 2060 GPU. Despite being only 1.65 inches tall, the NUC still has a decent amount of power. Its CPU even has a maximum boost clock of 4.7GHz. Plus, it has a Turing GPU and can handle light ray tracing.

With everything running smoothly, it was just a matter of custom printing 3D brackets to hold the parts in place. Then they had to polish it up to make it aesthetically pleasing. Finishing it off is a massive keyboard of unknown providence. However, it's proportional to the rest of the notebook and fits right in. There's also a built-in trackpad and tiny windows on the deck to let them monitor the batteries tucked inside.

 
 

The guts include three batteries, an Intel NUC, and a giant keyboard.

On the one hand, the project was a success, but it would be interesting to see if they could make it lighter by using more plastic instead of wood. However, that might not be rigid enough to keep the chassis from flexing. As the hosts note, you must put a pad on your legs to use it as a laptop. Also, its size requires two people to open the panel, so it's not practical.

The project is reminiscent of the world's biggest Xbox Series X. That was equally ridiculous as it was almost 7 feet tall and weighed over 250 pounds. Still, it was a legit Xbox and got certified by the Guinness Book of World Records. As far as we can tell, the 43-inch laptop has not been awarded any "world's largest" certifications. The couple says you can buy the "BFL laptop" for three easy payments of $999, although it's just a parody ad.

Now read:

 
 
 
Investing smartly in climate change adaptation
 
 
 
Is this article about Weather?
 
Until the world stops or slows our greenhouse gas emissions, we won't know just how severe climate change effects like sea level rise and extreme weather will be. A new framework could help communities when making often irreversible climate adaptation decisions under this uncertainty—so they're not spending so much that they're left servicing unnecessary debt, and not spending so little that they're left unprotected.
 
 
 
 
Is this article about Ecosystem Management?
 
Based on a new study, the carbon sequestration of suppressed spruces recovered during the following growth season after a selection harvesting. This is great news from the perspective of climate change. The prerequisites for practicing continuous cover forestry in fertile drained peatland forests are also good from the perspective of tree growth, as the slow stem diameter growth period, sc. "release effect" proved to be relatively short.
 
 
 
Researchers find HERC1 protein deficiency causes osteopenia
 
 
 
 
Bones remain healthy thanks to the fact that they are continuously remodeling, a process dependent on the balance between the activity of osteoblasts—cells that create bone tissue—and the osteoclasts, which reabsorb it. An imbalance between these two can disrupt bone homeostasis and lead to diseases such as 
osteopenia
, which is a loss of bone mass.
 
 
 
 
Is this article about Ecosystem Management?
 
Based on a new study, the carbon sequestration of suppressed spruces recovered during the following growth season after a selection harvesting. This is great news from the perspective of climate change. The prerequisites for practicing continuous cover forestry in fertile drained peatland forests are also good from the perspective of tree growth, as the slow stem diameter growth period, sc. "release effect" proved to be relatively short.
 
 
 
 
 
Bones remain healthy thanks to the fact that they are continuously remodeling, a process dependent on the balance between the activity of osteoblasts—cells that create bone tissue—and the osteoclasts, which reabsorb it. An imbalance between these two can disrupt bone homeostasis and lead to diseases such as 
osteopenia
, which is a loss of bone mass.
 
 
 
 
 
Many people choose to live with a cat for companionship. As a social species, companionship is something we often crave. But this cannot necessarily be said of our feline friends. Domestic cats evolved from a largely solitary species, defending their territory from other cats.
 
 
 
 
Is this article about Agriculture?
 
Biomass refers to biological organisms, including plants, that synthesize organic matter utilizing solar energy and animals that use these plants as food. Biomass also includes resources that can be converted into chemical energy. To achieve carbon neutrality by 2050, substantial efforts have been made worldwide to develop biorefinery technology that can replace fossil fuels with biofuels. However, the conventional biofuel production process involves the use of highly toxic solvents, which are mainly derived from petroleum causing environmental and economic concerns.
 
 
 
 
 
Elevated near-surface ozone pollutes many parts of the world, exerting consequential impacts on human health in ozone-prone regions, including southeastern China, the southeastern United States, and Europe. Key meteorological conditions, such as downward surface shortwave radiation, intensify ozone pollution, yet how these meteorological conditions or associated mechanisms respond to global warming remains unknown.
 
 
 
 
Is this article about Agriculture?
 
Biomass refers to biological organisms, including plants, that synthesize organic matter utilizing solar energy and animals that use these plants as food. Biomass also includes resources that can be converted into chemical energy. To achieve carbon neutrality by 2050, substantial efforts have been made worldwide to develop biorefinery technology that can replace fossil fuels with biofuels. However, the conventional biofuel production process involves the use of highly toxic solvents, which are mainly derived from petroleum causing environmental and economic concerns.
 
 
 
Insights into the evolution of the sense of fairness
 
 
 
 
A sense of fairness has long been considered purely human — but animals also react with frustration when they are treated unequally by a person. In a study with long-tailed macaques (Macaca fascicularis), researchers have now confirmed an alternative explanatory approach. A combination of social disappointment with the human experimenter and some degree of food competition best explains their behavior in an 'inequity aversion' experiment.
 
 
 
Scholars unify color systems using prime numbers
 
 
 
Is this article about Tech & Scientific Innovation?
 
Existing color systems, such as RGB and CYMK, are all text-based and require a large range of values to represent different colors, making them difficult to compute and time-consuming to convert. Recently, researchers made a breakthrough by inventing an innovative color system, called 'C235', based on prime numbers, enabling efficient encoding and effective color compression. It can unify existing color systems and has the potential to be applied in various applications, like designing an energy-saving LCD system and colorizing DNA codons.
 
 
 
The retention problem: Women are going into tech but are also being driven out
 
 
 
 
By 2029, there will be 3.6 million computing jobs in the U.S., but there will only be enough college graduates with computing degrees to fill 24% of these jobs. For decades, the U.S. has poured resources into improving gender representation in the tech industry. However, the numbers are not improving proportionately. Instead, they have remained stagnant, and initiatives are failing.
 
 
 
Three ways to prevent school shootings, based on research
 
 
 
 
In the months leading up to his 2012 attack that killed 26 people in Newtown, Connecticut, a 20-year-old man exhibited a cascade of concerning behaviors. He experienced worsening anorexia, depression and obsessive-compulsive disorder. His relationships deteriorated, and he became fixated on mass murders.
 
 
 
 
 
Visible light is just one part of the electromagnetic spectrum that astronomers use to study the universe. The James Webb Space Telescope was built to see infrared light, other space telescopes capture X-ray images, and observatories like the Green Bank Telescope, the Very Large Array, the Atacama Large Millimeter Array and dozens of other observatories around the world work at radio wavelengths.
 
 
 
 
 

Nature Communications, Published online: 03 March 2023; doi:10.1038/s41467-022-35611-9

The trifluoromethyl anion rapidly decomposes into difluorocarbene (:CF2) and fluorine ion, limiting its applicability in synthesis. Here, the authors report a strategy to generate and use the short-lived CF3- intermediate from stable CF3H gas via fast biphasic mixing in precisely customized flow dissolvers.
 
 
 
 
 
Though wildlife trafficking has been effectively disrupted since the first World Wildlife Day—established 50 years ago today via the 1973 Convention on International Trade in Endangered Species (CITES) of Wild Fauna and Flora—a newly published case study on one of the world's rarest tortoise species, the ploughshare tortoise, highlights how much room for improvement still exists.
 
 
 
 
 
Though wildlife trafficking has been effectively disrupted since the first World Wildlife Day—established 50 years ago today via the 1973 Convention on International Trade in Endangered Species (CITES) of Wild Fauna and Flora—a newly published case study on one of the world's rarest tortoise species, the ploughshare tortoise, highlights how much room for improvement still exists.
 
 
 
Pandemic pet boom has increased the demand for pet-friendly workplaces
 
 
 
 
About one in three Canadian households have adopted a pet since the start of the pandemic. Around one-third of these are first-time pet owners. These "pandemic pets," along with their pre-pandemic counterparts, have brought a great deal of comfort during the lockdown, with owners reporting a deepening of their bonds with their pets.
 
 
 
Tracing the history of grape domestication using genome sequencing
 
 
 
 
A large international team of scientists with various backgrounds has discovered that there were two domestication pathway events for grapes that led to their use in winemaking. In their paper published in the journal Science, the group describes conducting the largest-ever genome sequencing of grapevine varieties, mostly during pandemic lockdowns. Robin Allaby with the University of Warwick, has published a Perspectives piece in the same journal issue outlining the work done by the team.
 
 
 
 
 
A large international team of scientists with various backgrounds has discovered that there were two domestication pathway events for grapes that led to their use in winemaking. In their paper published in the journal Science, the group describes conducting the largest-ever genome sequencing of grapevine varieties, mostly during pandemic lockdowns. Robin Allaby with the University of Warwick, has published a Perspectives piece in the same journal issue outlining the work done by the team.
 
 
 
How fish evolved to walk
 
 
 
 
When you think about human evolution, there's a good chance you're imagining chimpanzees exploring ancient forests or early humans daubing wooly mammoths on to cave walls. But we humans, along with bears, lizards, hummingbirds and Tyrannosaurus rex, are actually lobe-finned fish.
 
 
 
 
 
About 25 million kilometers of new roads are expected to be built around the world by 2050. Along with power lines and railways, roads cut through the landscape everywhere, disrupting ecosystems. This linear infrastructure prevents animals from moving safely around their habitat. It also reduces access to the resources they need, like food, sufficient space and mating partners.
 
 
 
Bank of America Obsessed With AI, Says It's the "New Electricity"
 
 
 
 
The financial industry's response to AI has been bizarre at best, with Bank of America weighing in very much on the side of the bots. 
 
 

BofA AIs

The financial industry's response to artificial intelligence has been all over the place. Now, Bank of America is weighing in very much on the side of the bots.

In a note to clients viewed by CNBC and other outlets, BofA equity strategist Haim Israel boasted that AI was one of its top trends to watch — and invest in — for the year, and used all kinds of hypey language to convince its clients.

"We are at a defining moment — like the internet in the '90s — where Artificial Intelligence (AI) is moving towards mass adoption," the client note reads, "with large language models like ChatGPT finally enabling us to fully capitalize on the data revolution."

Taking the comparison further, Israel added that software like OpenAI's game-changing ChatGPT will become an essential commodity.

"If data is the new oil," the strategist predicted, "then AI is the new electricity."

Hot and Cold

With AI at the apparent forefront of its trend forecasting, the financial institution highlighted multiple big tech stocks in a separate list of stocks to watch — but BofA's apparent pro-AI obsession does not seem to be shared by some of its competitors.

Just last week, JP Morgan went so far as to ban employees from using ChatGPT at work, citing "compliance concerns" per CNN's reporting.

Though its stance wasn't as strict as its compatriot's, Morgan Stanley reportedly is also concerned with the downsides of AI, too.

"When we talk of high-accuracy task," Morgan Stanley analysts wrote in a note viewed by Insider last week, "it is worth mentioning that ChatGPT sometimes hallucinates and can generate answers that are seemingly convincing, but are actually wrong."

With AI making massive waves in the finance industry and everywhere else, it's not surprising that big banks are responding in different ways — though to be honest, these disparate reactions does suggest serious ambiguity in the new space.

More on ChatGPT and banks: Journalist Clones His Voice and Uses It to Break Into His Own Bank Account

The post Bank of America Obsessed With AI, Says It's the "New Electricity" appeared first on Futurism.

 
 
 
 
Is this article about Tech & Scientific Innovation?
 
Existing color systems, such as RGB and CYMK, are all text-based and require a large range of values to represent different colors, making them difficult to compute and time-consuming to convert. Recently, researchers made a breakthrough by inventing an innovative color system, called 'C235', based on prime numbers, enabling efficient encoding and effective color compression. It can unify existing color systems and has the potential to be applied in various applications, like designing an energy-saving LCD system and colorizing DNA codons.
 
 
 
How fish evolved to walk
 
 
 
 
When you think about human evolution, there's a good chance you're imagining chimpanzees exploring ancient forests or early humans daubing wooly mammoths on to cave walls. But we humans, along with bears, lizards, hummingbirds and Tyrannosaurus rex, are actually lobe-finned fish.
 
 
 
 
 
Technology nearly derailed the conclusion of the 2023 presidential elections in Nigeria. The Independent National Electoral Commission could not fulfill its promise to transmit election results from the polling units on its result viewing portal (IReV). This led to calls by some political parties for cancelation and fresh elections. The Conversation Africa asked political scientist Abiodun Fatai how Nigeria can improve its election digitization.
 
 
 
 
 
About 25 million kilometers of new roads are expected to be built around the world by 2050. Along with power lines and railways, roads cut through the landscape everywhere, disrupting ecosystems. This linear infrastructure prevents animals from moving safely around their habitat. It also reduces access to the resources they need, like food, sufficient space and mating partners.
 
 
 
 
 
HSBC has recently introduced what it calls a "more casual" uniform for its branch staff, including jumpsuits and jeans, "menopause-friendly" clothing, as well as "ethnic wear". The uniforms aim to make staff immediately visible to customers and also signal a clear corporate message of a friendly, approachable high street bank.
 
 
 
Study reveals link between selenium and COVID-19 severity
 
 
 
 
Chemists from the University of North Carolina at Greensboro released a study in the journal Antioxidants revealing a new basis for the link between dietary selenium and COVID-19 severity. Building on a previous study that identified a set of six host proteins potentially targeted by SARS-CoV-2, their study confirmed cleavage of three previously predicted protein target sites from selenoproteins, which have antioxidant and antiviral defensive roles.
 
 
 
 
 
Chemists from the University of North Carolina at Greensboro released a study in the journal Antioxidants revealing a new basis for the link between dietary selenium and COVID-19 severity. Building on a previous study that identified a set of six host proteins potentially targeted by SARS-CoV-2, their study confirmed cleavage of three previously predicted protein target sites from selenoproteins, which have antioxidant and antiviral defensive roles.
 
 
 
Learning how cells respond to stressful conditions
 
 
 
 
Developing approaches to protect human well-being in a changing climate will depend on a deeper understanding of how mammalian cells and organisms adapt to dramatic shifts in temperature and in the availability of food and water. To help build this knowledge base, Institute researchers are exposing cells from multiple types of mammals to a range of increased and decreased temperatures; then they are observing the mechanisms the cells may use to survive extreme conditions.
 
 
 
The dual face of photoreceptors during seed germination
 
 
 
 
Seed germination depends on light in many plants. But not always: Aethionema arabicum, a plant adapted to challenging environmental conditions, does it its own way. Here, the phytochromes, the receptors for red and far-red light, play an unexpected role in seed germination and time this process to the optimal season.
 
 
 
 
 
Developing approaches to protect human well-being in a changing climate will depend on a deeper understanding of how mammalian cells and organisms adapt to dramatic shifts in temperature and in the availability of food and water. To help build this knowledge base, Institute researchers are exposing cells from multiple types of mammals to a range of increased and decreased temperatures; then they are observing the mechanisms the cells may use to survive extreme conditions.
 
 
 
 
 
Seed germination depends on light in many plants. But not always: Aethionema arabicum, a plant adapted to challenging environmental conditions, does it its own way. Here, the phytochromes, the receptors for red and far-red light, play an unexpected role in seed germination and time this process to the optimal season.
 
 
 
This Week in Space: Stargates, Stardates, and the Leidenfrost Effect
 
 
 
Feedly AI found 1 Partnerships mention in this article
  • Undaunted, this week, the European Space Agency announced a joint effort to establish a timekeeping standard for the moon.
 
 
 
NASA astronauts Stephen Bowen and Warren "Woody" Hoburg by the crew access arm on the fixed service structure of Launch Complex 39A as fellow crewmates Roscosmos cosmonaut Andrey Fedyaev and UAE (United Arab Emirates) astronaut Sultan Alneyadi exit the elevator the floor below before boarding SpaceX's Dragon spacecraft atop the company's Falcon 9 rocket before the launch of NASA's SpaceX Crew-6 mission to the International Space Station, Wednesday, March 1, 2023, at NASA's Kennedy Space Center in Florida. NASA's SpaceX Crew-6 mission is the sixth crew rotation mission of the SpaceX Dragon spacecraft and Falcon 9 rocket to the International Space Station as part of the agency's Commercial Crew Program. Bowen, Hoburg, Roscosmos cosmonaut Andrey Fedyaev, and UAE (United Arab Emirates) astronaut Sultan Alneyadi launched at 12:34 a.m. EST from Launch Complex 39A at the Kennedy Space Center to begin a six month mission aboard the orbital outpost. Photo Credit: (NASA/Joel Kowsky)

 

(Credit: NASA)
Hello, readers, and welcome back. There's much ado about the moon this week and a ton of launches scheduled for March. The James Webb space telescope is seeing triple — and that's a good thing. Meanwhile, Hubble has been just as hard at work. Unfortunately, two NASA satellites are on the fritz. But we'll start today with news from Washington State of a very cool new way to manage space dust.

 

Frosty New Cleaning Spray Could Rid Space Suits of Moondust

In the most recent edition of Acta Astronautica, researchers from Washington State University report that a liquid nitrogen spray can rid space suits of moondust. Moondust is just like Mars dust: viciously sharp little shards of regolith that find their way inside everything. They're like packing peanuts or cursed space glitter. Worse than packing peanuts, moon dust is made of ultra-fine particles with the consistency of ground fiberglass.

"Moondust is electrostatically charged, abrasive and gets everywhere, making it a very difficult substance to deal with," said Ian Wells, first author of the report. "You end up with a fine layer of dust as a minimum just covering everything."

But the dust doesn't just cover everything. It does a great job wrecking everything it touches. Apollo astronauts tried to use brushes to clear their suits of the dust, but it was worse than nothing, clearing next to no dust and damaging the suits in the process. The grit destroyed seals in their space suits and caused the astronauts themselves to suffer from 'lunar hay fever.' Worse yet, experts believe longer exposure to moondust could cause a lunar 'black lung' syndrome. Since NASA is actively working to establish a long-term human presence on the moon, it's important to mitigate this threat. And that's where the liquid nitrogen comes in.

 
 

Astronaut Barbie gets really real. At least those plastic earrings are non-conductive. (Credit: WSU)

WSU researchers made one-sixth scale models of space suits, using Barbies to model them while they covered the suits in moondust. The researchers discovered that a spray of liquid nitrogen caused the moondust to "bead up and float away on the nitrogen vapor." Poetically, it's a phenomenon called the Leidenfrost effect. Here on Earth, you may have seen it in the way touchless car washes are gentler on a vehicle's finish than the kind that uses brushes. In the frigid vacuum on the lunar surface, liquid nitrogen might be the best way to clean that wretched dust off our next-gen space suits.

Cool.

'KaRIn' Instrument Knocks Out NASA's SWOT Satellite

Launched in December, the sea-gazing SWOT (Surface Water and Ocean Topography) satellite is a collaboration between space agencies of America, Canada, the UK, and France. According to NASA, it will take high-resolution measurements of the height of water in the world's oceans and freshwater bodies. That is — if it ever boots up again.

Once in orbit, the spacecraft started commissioning activities: the six-month "checkout period" before its scientific mission begins. This includes turning on all the satellite's science instruments, among them the main science instrument, the Ka-band Radar Interferometer (KaRIn). Engineers fully powered on the instrument in mid-January 2023, and everything looked great. The satellite sent back telemetry just fine — for a week. Then, one of the KaRIn instrument's subsystems shut down with no explanation. Naturally, it brought down the entire satellite and left the whole system pinwheeling.

In a statement, NASA officials said that mission engineers are "working systematically to understand the situation and to restore operations, performing diagnostics and working with a test bed that simulates the KaRIn instrument on Earth." The agency expects the satellite to finish its commissioning period in June, as originally scheduled, for the beginning of science operations in July.

IBEX Spacecraft Lapses Into Paralyzed 'Contingency Mode'

NASA's Interstellar Boundary Explorer (IBEX) spacecraft is suffering from a planned computer reset that went awry. Flight computer resets have happened before. However, NASA officials said, this time the IBEX team lost the ability to command the spacecraft altogether during what should have been a routine recovery after power cycling the computer.

 
 

Artist's rendering of the IBEX satellite. (Credit: NASA)

The spacecraft's flight software still is running, and its onboard systems appear to be functional. However, while uplink signals are reaching IBEX, it's not processing the commands it receives. The team also was unsuccessful in regaining control by power cycling and resetting hardware and software systems on the ground.

However, all is not lost. Even if NASA mission techs can't regain control of the computer, IBEX will perform an autonomous reset and power cycle on March 4. This affords another opportunity to get the spacecraft back to its primary mission: studying the boundary where our sun's solar wind gives way to the interstellar medium.

European Space Agency Moves to Establish a Lunar Time Zone

With multiple space agencies trying to establish a long-term human presence on the moon, it's important to be able to synchronize our various clocks. But timekeeping on the Moon is a fiddly thing, not unlike Star Trek's system of 'stardates,' which change depending on where you are in the galaxy. ExtremeTech's Adrianna Nine writes, "Clocks on the Moon run faster than what we consider normal here on Earth, gaining about 56 microseconds daily. This itself isn't consistent; how much faster these clocks run depends on their exact position on the Moon, causing organizations to wonder whether the Moon's time zone should be kept independent from Earth."

 
 

(Credit: Cristóbal Alvarado Minic/Wikimedia Commons)

Undaunted, this week, the European Space Agency announced a joint effort to establish a timekeeping standard for the moon. The common framework, LunaNet, will encapsulate "mutually agreed-upon standards, protocols, and interface requirements allowing future lunar missions to work together."

Archaeologists Find Gate Room Hidden Chamber Inside Great Pyramid of Giza

After years of painstaking work, scientists have used muon tomography to confirm the presence of a previously unknown chamber hidden behind the chevron blocks on the north face of the Great Pyramid of Giza. Thanks to the unique powers of the imaging method, scientists have now successfully mapped the space, and it appears to end in an upward-sloping corridor. They've even taken photos of it with an endoscopic imaging tool. Here's what you'd see if you peered down the corridor:

 
 

The scientists write:

Among these discoveries, a corridor-shaped structure has been observed behind the so-called Chevron zone on the North face, with a length of at least 5 meters. A dedicated study of this structure was thus necessary to better understand its function in relation with the enigmatic architectural role of this Chevron.

Muon imaging is ideal for investigating the Great Pyramid because it allows scientists to peer straight through solid rock. In this way, scientists can detect empty spaces that we otherwise wouldn't be able to find without dismantling the monument.

The scientists behind the study do not attempt to explain how the void was made or what its purpose might have been. However, fans of sci-fi may have some ideas. To quickly recap, we've discovered a mysterious space behind a chevon-shaped opening deep inside an Egyptian pyramid. There's an obvious explanation for this:

 
 

Chevron 1 encoded…

Reports of glowing-eyed "researchers" with imperious attitudes and strangely deep voices could not be confirmed at this time.

Launches and Landings

Three rockets may get their first taste of vacuum this month, one of them 3D-printed. ULA is going through last-minute tests before the inaugural flight of its Vulcan Centaur this spring. SpaceX is forging ahead with its next-gen Starlink satellites — and the company sent Crew-6 to the International Space Station in a striking midnight launch.

Relativity Space Schedules 'GLHF' Terran 1 Launch

Right now, Relativity Space's Terran 1 rocket is scheduled to lift off as early as March 8 (Wednesday) from Cape Canaveral. The methane-fueled rocket is mostly 3D-printed. Its mission, called "GLHF" (for "Good Luck, Have Fun"), is a test flight, which means it won't have an official payload — just sensors.

Relativity is working toward building another fully reusable rocket that will succeed Terran 1. The company is also collaborating with Impulse Space, trying to beat Elon Musk's SpaceX to Mars in their own miniature 'space race.'

JAXA Makes a Second Pass at H3 Rocket Launch

Japan's H3 satellite launcher may also make its first flight in March. The rocket was scheduled to launch in February, carrying an Earth-imaging satellite. However, things went pear-shaped during a Feb. 17 launch attempt when the rocket's side boosters failed to ignite. Spokespeople from the Japanese Aerospace Exploration Agency (JAXA) say that despite the launch failure, the rocket wasn't damaged. The agency intends to make another launch attempt next Friday (March 10).

SpaceX Starship Rocket Could Take Flight Within Weeks

SpaceX recently held a test fire of its simply-named Starship. During the test, 31 of its 33 Raptor engines fired, which Elon Musk says is entirely within the mission's margin of error. (Later, Musk said the engines had run at just half their expected thrust.) However, the FAA hasn't yet published its concurrence with Musk's opinions. SpaceX still needs to get the FAA's blessing in the form of a launch license before sending Starship to space.

 
 

Starship launches may cost as little as $2 million, which is 1,000 times less than the SLS. (Credit: SpaceX)

Gary Henry, senior advisor for national security space solutions at SpaceX, spoke to the issue during a panel discussion last week. "We hope to secure that license in the very near future," he said, for a launch attempt "probably in the month of March."

ULA Announces Target Date for Vulcan Centaur Launch

In a media briefing, ULA Chief Executive Tory Bruno announced a date for the long-awaited inaugural flight of the company's Vulcan Centaur rocket. Mission teams are running through a final series of tests of the rocket before its takeoff from Cape Canaveral's Space Launch Complex 41 'no earlier than' May 4.

 

ULA says the date depends on the outcome of these last tests of the rocket and its main engines. However, it's also constrained by launch windows for the rocket's payloads. In addition to Astrobotic's Peregrine lunar lander, the rocket will deploy a pair of prototype satellites for Amazon's upcoming Project Kuiper broadband constellation. It will also carry to orbit the remains of four U.S. presidents (Washington, Eisenhower, Kennedy, and Reagan) and other luminaries, including cast and crew from Star Trek, for space memorial company Celestis.

Good luck, folks. May the Fourth be with you.

Replacement Soyuz Docks With International Space Station

Finally! After weeks of scheduling bedlam, a replacement Soyuz capsule has arrived at the International Space Station.

In September, NASA astronaut Frank Rubio and Roscosmos cosmonauts Sergey Prokopyev and Dmitri Petelin flew to the ISS in a Soyuz capsule, MS-22. However, in mid-December, the capsule sustained a direct micrometeoroid strike to its external coolant loop. The impact destroyed the coolant system and left the capsule unfit to carry home the people it had carried to space.

Russia immediately set about launching a replacement Soyuz as fast as it could. But assorted problems, including a subsequent micrometeoroid impact to another Russian spacecraft (the Progress-82 cargo freighter docked to a different Russian module), ended up delaying that launch until last week.

The new capsule, Soyuz MS-23, will replace MS-22 as the ride home for Petelin, Prokpyev, and Rubio. However, for those watching the dates, the trio will be in orbit until this coming September — about double their expected stay.

Dazzling Midnight Launch Sends SpaceX Crew 6 to the International Space Station

After launching very early Thursday, the SpaceX Dragon capsule Endeavour docked with the ISS at 1:40 this morning, Eastern time.

 
 

Image: NASA/Joel Kowsky, via NASA HQ Flickr

The capsule is carrying the four members of SpaceX Crew-6: NASA astronauts Stephen Bowen and Warren Hoburg, along with Emirati Sultan Alneyadi and cosmonaut Andrey Fedyaev.

 

After Endeavour separated from its Falcon 9 rocket, an elated Hoburg radioed back to Earth: "Just want to say, as a rookie flyer, that was one heck of ride. Thank you!"

Hoburg added, "It's an absolute miracle of engineering, and I just feel so lucky that I get to fly on this amazing machine."

In a blog update, NASA did a complete roll call of the people currently aboard the station. The agency writes: "Crew-6 joins the Expedition 68 crew of NASA astronauts Frank Rubio, Nicole Mann, and Josh Cassada, as well as cosmonauts Anna Kikina, Dmitri Petelin, and Sergey Prokopyev, and JAXA astronaut Koichi Wakata." Until Crew-5 departs, there will be eleven people on the space station.

JWST Sees the Same Supernova 3 Times Through the Same Gravitational Lens

The James Webb space telescope is seeing triple — and that's a good thing. Thanks to gravitational lensing, the telescope has seized a rare opportunity to see the same supernova at three different times in its history, all in the same frame.

Gravitational lensing allows astronomers to take advantage of how massive objects like black holes and neutron stars 'bend' light by dragging in passing photons. Consequently, different photons from the same event can have paths of different lengths. This means they take different amounts of time to get to our telescopes — even though they're all traveling at the same speed. That lets an observer see through the same window into the life of a celestial object at different times in its history.

 

Now, between the telescope and the galaxy — which is River, and which is the Doctor?

Hubble Spies Cosmic Collision, 'Jellyfish Galaxy'

Not to be outdone by Webb and its fancy new mirrors, Hubble has been hard at work indeed. Recently, the telescope spied an epic cosmic collision of three separate galaxies…

 
 

A trio of merging galaxies in the constellation Boötes takes center stage in this image. (Credit: NASA/ESA)

…and a galactic seascape including a 'jellyfish galaxy' floating next to Cetus, the constellation of the Great Sea-Monster:

 

Skywatchers Corner

March though it may be, it's still cold out there and squelchy wherever it isn't icy. So this week, instead of sending you outside, I wanted to show you a time-lapse image of a planetary conjunction from last week, whose surpassing beauty stopped me in my tracks.

Over the winter, Jupiter and Venus have been slowly drifting together. Last Wednesday, the Moon slipped between the two planets in their close approach for just one night. This Wednesday, Jupiter and Venus entered conjunction, visible in the evening sky less than a degree apart. In a stunning ten-day photo collage titled "10 Days of Nearness," astrophotographer Soumyadeep Mukherjee of Dhanbad, India, captured the planets' graceful arc of approach against the rich pastels of the gathering dusk.

 
 

The Moon joins Venus and Jupiter in the second panel from left. Credit and copyright Soymyadeep Mukherjee, 2023, via Space.com

Mukherjee told Space.com that he's part of a group known as Astronomads Bangla, which "works towards popularizing astrophotography in India." H/t to Space for boosting the signal and to Mr. Mukherjee himself for the work of celestial art. For more, check out his portfolio on Instagram.

Feature image credit: NASA/Joel Kowsky

Now Read:

 
 
 
Small differences in mom's behavior may show up in child's epigenome
 
 
 
Is this article about Animals?
 
Adding evidence to the importance of early development, a new study links neutral maternal behavior toward infants with an epigenetic change in children related to stress response. Epigenetics are molecular processes independent of DNA that influence gene behavior. In this study, researchers found that neutral or awkward behavior of mothers with their babies at 12 months correlated with an epigenetic change called methylation, or the addition of methane and carbon molecules, on a gene called NR3C1 when the children were 7 years old. This gene has been associated with regulating the body's response to stress.
 
 
 
 
Is this article about Neuroscience?
 
A new study finds that high school students identify more with math if they see their math teacher treating everyone in the class equitably, especially in racially diverse schools. The study by researchers at Portland State University, Loyola University Chicago and the University of North Texas was published in the journal Sociology of Education. Dara Shifrer, associate professor of sociology at Portland State and former middle school math teacher, led the study.
 
 
 
 
Is this article about Agriculture?
 
A trio of climate scientists from Occidental College, Claremont Graduate University and the University of California, respectively, has found that after a 50-minute talk outlining the negative environmental impacts of raising and consuming meat, students ate on average 9% less meat over the following three years. In their paper published in the journal Nature Food, Andrew Jalil, Joshua Tasoff and Arturo Vargas Bustamante describe analyzing the eating habits of student volunteers.
 
 
 
Researchers reveal disturbances of Tonga volcanic eruption
 
 
 
 
Recently, a team led by Prof. Lei Jiuhou from University of Science and Technology of China (USTC) of the Chinese Academy of Sciences and the collaborators revealed the notable evidence of the dramatic thermospheric disturbances and global upper thermospheric perturbations of the Tonga eruption (January 15, 2022), and confirmed that the impact of volcanic eruption has outreached the ionosphere and creeps into the thermospheric density up to 500 km satellite orbiting altitudes. This study was published in Geophysical Research Letters.
 
 
 
 
 
Phosphorus (P) is a macronutrient essential for various biological processes in plants. Inorganic phosphate (Pi) deficiency modulates the signaling pathway of the phytohormone jasmonate (a fatty acid compound ubiquitous in the plant kingdom and crucial for various physiological processes) in Arabidopsis thaliana, but the underlying molecular mechanism currently remains elusive.
 
 
 
 
Is this article about Global Health?
 
Poor mental health among employees has an enormous impact on the global economy, costing companies about $1 trillion annually in lost productivity by some estimates—and the toll is only expected to rise. But as employers scramble to address mental health issues, their efforts could actually be backfiring.
 
 
 
Guy Launches News Site That's Completely Generated by AI
 
 
 
Is this article about Tech?
 
The "world's first" entirely AI-generated news channel is here, claiming to be the antidote to biased news. It's called NewsGPT, and we hate it.
 
 

The "world's first" entirely AI-generated news site is here. It's called NewsGPT, and it seems like an absolutely horrible idea.

The site, according to a press release, is a reporter-less — and thus, it claims, bias-free — alternative to conventional, human-created news, created with the goal of "[providing] unbiased and fact-based news to readers around the world."

"For too long," Alan Levy, NewsGPT's CEO, said in the release, "news channels have been plagued by bias and subjective reporting. With NewsGPT, we are able to provide viewers with the facts and the truth, without any hidden agendas or biases."

Okay. While we understand that a lot of folks out there are frustrated with the modern news cycle, there are about a million problems with what this guy is doing, the least of which being that there are some glaring transparency problems here — which is pretty incredible, given everything that he claims to be railing against.

First and foremost, while its title suggests that it might be using a version of OpenAI's GPT — the Large Language Model (LLM) that powers OpenAI's viral ChatGPT chatbot — Levy fails to ever actually disclose which AI program he's using to power NewsGPT. All the release says is that NewsGPT is powered by "state-of-the-art machine learning algorithms and natural language processing technology" that's allegedly "able to scan relevant news sources from around the world in real-time."

"It then uses this data," the press release reads, "to create news stories and reports that are accurate, up-to-date, and unbiased."

Great. Sure. But again: what is it? It matters! AI software doesn't just spring into existence. Models are conceptualized, built, and programmed by humans, and disclosing which humans are making the underlying tech seems like it should be pretty important to Levy's alleged mission.

When Futurism reached out to NewsGPT for comment, all a spokesperson said was that they're using a "combination of AI programs," which doesn't answer the question (they also bragged that "part of this email is written by AI," without specifying which part.)

Speaking of the underlying tech, we're not just concerned about who's building it. From ChatGPT to Bing Search to CNET's mystery AI journalism machine, language-generating AIs are notorious for the penchant to hallucinate — or, in other words, just make shit up. They don't know what words mean, they just predict what might come next in a sentence, even making up phony sources and numbers to support BS claims.

For its part, NewsGPT did admit to us that machine hallucinations "might" happen. But as they seem to frame it, machine hallucination isn't that big of a deal. It's only "fact-based" news, right?

"There are no human fact-checkers. Our news stories are generated 100 percent by AI. We are aware that 'AI hallucinations' might happen and that AI is far from a perfect technology," the company told us over email. "We are committed to learning fast and improving all the time to deliver the best AI news we can."

To that end, when it comes to, dunno, news, sources are extremely important. With the exception of an occasional in-text mention of where a specific figure may have come from, NewsGPT's articles overwhelmingly fail to link back to any of its references, offering alleged facts and figures, which have to come from somewhere — unless, of course, the machine makes them up — without mention of its origin.

Seems like an issue. But to NewsGPT, that, too, is just a growing pain.

"NewsGPT and AI are in hyper-growth phases," the firm said. "We are currently developing an AI 'best practice system' regarding sources and links."

But to that point, gotta say: if the tech is just scraping, paraphrasing, and regurgitating news found from other "relevant news sources" without giving credit, isn't that just… plagiarism? Of the human journalists that Levy says no one can trust? Who write for the companies that Levy says have "hidden agendas and biases"?

"By using the process of generative modeling, NewsGPT generates new and original stories," adding that their still-unspecified "AI model also looks for text that matches existing content too closely and actively tries to rectify this."

Sure. Again, though: we'll believe it when we see it. But considering that AI leaders at OpenAI, Microsoft, and Google haven't quite figured that piece out — or figured out any of these issues, really — we won't hold our breath.

We'd also be remiss not to mention that while human bias exists, machine bias certainly does too. Though Levy effectively markets NewsGPT as a faceless, apolitical ghost reporter, capable of finding and delivering only the facts, LLMs and similar tools are a mirror to humanity — often the worst parts of it — and not the antidote that folks like Levy promise it to be; the AI industry has yet to create a system that isn't riddled with deeply embedded bias.

At the end of the day, when it comes to news and journalism, generative AI programs may one day prove to have some helpful assistive qualities (Wired's approach, released this week, is notably respectable.) But as it stands, we've yet to see a miracle system that can safely and reliably deliver accurate and unbiased journalism without human intervention — and even with human involvement, these programs have failed time and again, a result of their own flaws as well as our own.

Anyway. Please don't get your news from NewsGPT.

More on AI journalism: CNET Hits Staff With Layoffs After Disastrous Pivot to AI Journalism

The post Guy Launches News Site That's Completely Generated by AI appeared first on Futurism.

 
 
 
Elon Musk's SpaceX Satellites Are Messing Up the Hubble Space Telescope
 
 
 
 
As private companies like SpaceX pour thousands of satellites into the sky, even the veteran Hubble is having trouble getting a clear look at the cosmos.
 
 

Humbling the Hubble

The poor ol' 

Hubble Space Telescope

 is already being overshadowed by its glorious successor, the James Webb. And now, seemingly unable to catch a break after thirty years of loyal service, the Hubble's having some trouble peering through an increasingly crowded sky.

According to a new study published in the journal Nature Astronomy, more and more images captured by Hubble are being tainted by satellites in orbit, which have drastically shot up in number since the telescope launched in 1990.

"We're going to be living with this problem. And astronomy will be impacted," Jonathan McDowell, an astronomer at the Harvard-Smithsonian Center for Astrophysics who was not involved in the study, told The New York Times.

"There will be science that can't be done," he added. "There will be science that's significantly more expensive to do. There will be things that we miss."

The Big Culprit

Many of these troublesome satellites are launched by a host of private companies. But the ones that draw the most ire belong to SpaceX, whose Starlink satellites are renowned for their bright, linear formations in the sky.

From 2009 to 2020, the odds of a satellite appearing in a Hubble image sat at 3.7 percent. But just one year later in 2021, that number dramatically shot up to 5.9 percent. The culprit for the increase, naturally, were the many Starlink satellites launched over that time period.  Since the study's cutoff in 2021, the amount of Starlink satellites in orbit has more than doubled to over 3,500.

When astronomers decried the Starlink satellites for obstructing ground-based telescopes, SpaceX founder and CEO Elon Musk, callously suggested that they simply "move telescopes to orbit."

But even if astronomer's were able to abide Musk's suggestion, which would be ridiculously expensive and wasteful, it still wouldn't solve the problem. Hubble, obviously, has always been in orbit over 300 miles above Earth, and if it's getting affected there, how far must astronomers across the globe go to accommodate Starlink's satellites?

"Not only do you have to put your telescopes in space, but you also have to put them above all the other traffic," McDowell said.

Invasion of the Satellites

Right now, the interference is only minor, and in most cases can be "readily removed using standard data reduction techniques, and the majority of affected images are still usable," a NASA spokesperson told NYT.

In years to come, though, that will almost certainly change. The study estimates that there could be up to 100,000 satellites encircling the planet by the 2030s. Starlink on its own wants to reach 42,000 in orbit.

"When will Hubble not be useful anymore?" asked study co-author Mark McCaughrean, an astronomer at the European Space Agency. "That might be 10 or 20 years away, but it's not inconceivable that there's a point at which you say, 'Let's not bother anymore.'"

More on space: Large, Mysterious Object Getting Sucked Into Milky Way's Supermassive Black Hole

The post Elon Musk's SpaceX Satellites Are Messing Up the Hubble Space Telescope appeared first on Futurism.

 
 
 
 
 
Phosphorus (P) is a macronutrient essential for various biological processes in plants. Inorganic phosphate (Pi) deficiency modulates the signaling pathway of the phytohormone jasmonate (a fatty acid compound ubiquitous in the plant kingdom and crucial for various physiological processes) in Arabidopsis thaliana, but the underlying molecular mechanism currently remains elusive.