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Nature Communications, Published online: 09 March 2023; doi:10.1038/s41467-023-36993-0 Arboviruses and symbiotic viruses can be paternally transmitted by male insects to their offspring, but the mechanism remains largely unknown. Here, the authors identify the sperm-specific serpin protein HongrES1 of the leafhopper Recilia dorsalis as a mediator of paternal transmission of the reovirus rice gall
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Nature Communications, Published online: 09 March 2023; doi:10.1038/s41467-023-36929-8 Quantum sensors based on NV centers in diamond are well established, however the sensitivity of detection of high-frequency radio signals has been limited. Here the authors use nanoscale field-focusing to enhance sensitivity and demonstrate ranging for GHz radio signals in an interferometer set-up.
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Millennia ago, early humans walked out of Africa and spread across the world in a way that few other species have. In this eBook, we examine how and why this happened, tracing insights from genome analyses as well as studies of footprints, tools, cave art and oral histories. We also look at the forces driving current human migration and where our journey might take us in the future.
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I've heard several times that a true holodeck is hundreds of years from development, but what about having one in a vr headset? As far as the capabilities, since a basic version of this already exists, it would need to have the ability to fully control the environment to anything you could imagine (I would think you would need a suitable AI to be able to map environments out based on specified pa
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The film Everything Everywhere All at Once has enjoyed critical acclaim and awards success. Ahead of the Oscars, where it’s tipped to sweep the board, Ian Sample speaks to theoretical physicist and philosopher Sean Carroll about why we seem to be drawn to the idea of multiple worlds, and what the science says about how the multiverse might actually work Clips: Everything Everywhere All at Once (A
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The film Everything Everywhere All at Once has enjoyed critical acclaim and awards success. Ahead of the Oscars, where it’s tipped to sweep the board, Ian Sample speaks to theoretical physicist and philosopher Sean Carroll about why we seem to be drawn to the idea of multiple worlds, and what the science says about how the multiverse might actually work. Help support our independent journalism at
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To better understand what I mean. Sooner or later grocery stores won't even need people anymore. Factories will have no need for people. Same thing with truck driving. So many things will be taken over with automation. So, right now I'm only 24 years old. But what type of world will I be living in when I'm 45? 50? Obviously we can't predict the future perfectly. But are there any particular skill
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Much of the progress made in understanding the scope of bird deaths from building and window collisions has come as the result of citizen science, according to a newly published study. But the study also concludes that such grassroots efforts need more buy-in from government and industry, and better funding so they can keep a foot on the gas in their efforts to reduce bird-window collisions.
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A commonly used scientific method to analyze a tiny amount of DNA in early human embryos fails to accurately reflect gene edits, according to new research. Although gene editing technologies hold promise in preventing and treating debilitating inherited diseases, the new study reveals limitations that must be overcome before gene-editing to establish a pregnancy can be deemed safe or effective.
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Kari Lake, who’s still trying to overturn her November election loss in Arizona, is one of four women Trump is considering for VP, according to a new report from Axios. Lake is flirting with another possibility too. But first, here are three new stories from The Atlantic . A view of American history that leads to one conclusion Arnold Schwarzenegger’s last act Prepare for the textpocalypse. Seein
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Pandemic resulted in ‘minimal’ changes in symptoms, according to review led by McGill University researchers Covid-19 may not have taken as great a toll on the mental health of most people as earlier research has indicated, a new study suggests. The pandemic resulted in “minimal” changes in mental health symptoms among the general population, according to a review of 137 studies from around the w
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In the first step toward understanding how dogs—and perhaps humans—might adapt to intense environmental pressures such as exposure to radiation, heavy metals, or toxic chemicals, researchers have found that two groups of dogs living within the Chernobyl Exclusion Zone, one at the site of the former Chernobyl reactors, and another 16.5 km away in Chernobyl City, showed significant genetic differenc
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While more businesses continue to shift to remote work, some well-known CEOs remain steadfast against the movement. Naresh Khatri, an associate professor of health management and informatics in the School of Medicine at the University of Missouri, said the success of shifting to remote work depends on the flexibility of the organization to adjust to individual employees and the technology availabl
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In the first step toward understanding how dogs—and perhaps humans—might adapt to intense environmental pressures such as exposure to radiation, heavy metals, or toxic chemicals, researchers have found that two groups of dogs living within the Chernobyl Exclusion Zone, one at the site of the former Chernobyl reactors, and another 16.5 km away in Chernobyl City, showed significant genetic differenc
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Ninety-nine percent of the global population — practically everyone in the entire world — is exposed to harmful air pollutants known as PM 2.5, according to a massive study recently published in the journal The Lancet Planetary Health . Conversely, it found that only 0.001 percent of the global population live in areas with levels of PM 2.5 below the safe threshold recommended by the World Health
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Doublethink We're closer than ever to a dystopian future in which corporations can read our thoughts without our permission — and a leading legal theorist thinks we should head that eventuality off before it becomes a reality. In an interview with The Guardian , Duke Law professor and brain-hacking "neurotechnology" critic Nita Farahany said that although brain-computer interface tech "can’t lite
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Among a group of coworkers, one employee can sometimes emerge as an informal leader, a go-to person to solve problems and answer questions. As a result, most managers assign that employee the most important tasks and the best opportunities for professional development and growth.
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The NISAR Earth science mission has moved a step closer to its 2024 launch. Its science payload of two radar systems, one built by NASA and the other by the Indian Space Research Organization (ISRO), recently completed the journey from NASA's Jet Propulsion Laboratory in Southern California to ISRO's U R Rao Satellite Center in Bengaluru, India. Soon, teams at the facility will combine the radar s
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In our family, my aunt Burnette was the designated photographer. Or at least that was what I thought when, as a child, I’d page through the family photo albums at her home. Her beautiful portraits—of my cousins, grandparents, aunts, uncles, and great-grandparents in southeastern Wisconsin—captured silly faces, warm cuddles, flawless stunting. She documented the fact of us. I wasn’t aware at the t
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Remember that dystopian, Big Box VR shopping video? It was dull and boring and filled me with dread. How would you make this more fun? (assuming the tech is there, which feels increasingly likely given the acceleration in the space with Oculus Pro and Samsung re-entering the hardward game) My idea, as gleaned from this short video , is a gamified experience. One where Supermarket Sweep meets Twis
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Need access to blocked social media accounts or confidential information? I'm a professional hacker ready to help. I can restore any social media account and find the information you need. Contact me through my Instagram account hacktech_48. submitted by /u/RedreLife [link] [comments]
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Rice is one of the most important crops in the world and constitutes the primary food source for over half of Earth's population. Protecting rice plantations from disease is therefore an essential endeavor in modern agriculture. Of the many pathogens that can infect rice plants, the bacterium Xanthomonas oryzae, which is responsible for bacterial blight (BB), is among the worst. Hundreds of millio
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University of Central Florida researcher Debashis Chanda, a professor in UCF's NanoScience Technology Center, has drawn inspiration from butterflies to create the first environmentally friendly, large-scale and multicolor alternative to pigment-based colorants, which can contribute to energy-saving efforts and help reduce global warming.
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Rice is one of the most important crops in the world and constitutes the primary food source for over half of Earth's population. Protecting rice plantations from disease is therefore an essential endeavor in modern agriculture. Of the many pathogens that can infect rice plants, the bacterium Xanthomonas oryzae, which is responsible for bacterial blight (BB), is among the worst. Hundreds of millio
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Making living cells blink fluorescently like party lights may sound frivolous. But the demonstration that it’s possible could be a step toward someday programming our body’s immune cells to attack cancers more effectively and safely. That’s the promise of the field called synthetic biology. While molecular biologists strip cells down to their component genes and molecules to see how they work…
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Suspicious that Richard is selling to his customers, Mike uses a drone to track down Richard's still sight. #discoveryplus #moonshiners Stream Full Episodes of Moonshiners https://www.discoveryplus.com/show/moonshiners About Moonshiners: Every spring, a fearless group of men and women venture deep into the woods of Appalachia, defying the law, rivals and nature itself to keep the centuries-old tr
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A group of gifted elementary school students has discovered that EpiPens, life-saving devices that inject epinephrine in the case of a severe allergic reaction, can turn poisonous after being launched into space — more evidence of the harrowing effects space radiation can have on the health of astronauts. The students helped researchers at the University of Ottawa in Canada investigate whether th
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I was standing in line for a tourist attraction in Tokyo when a small robot began addressing the crowd. The robot resembled Rosey from The Jetsons and was meant to amuse people while they waited. It babbled for a while, and then its eyes turned into two pink hearts. “I love everyone,” it announced. “Oh, really?” I responded sarcastically. I couldn’t help myself. “Everyone? That’s disingenuous.” Th
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On Aug. 3, 2019, only hours after a mass shooting in El Paso, Texas, which left 23 people dead, a familiar talking point reared its head: video games were to blame. The question of whether video games incite real-world violence among kids and teens has been sparking controversy — and headlines — for decades. But despite more than 20 years of investigation, researchers have failed to prove a causal
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Before and after the 2016 U.S. presidential election, Russia's Internet Research Agency purchased tens of thousands of Facebook ads in an effort to stoke division among Americans. Their effect on the election is hard to quantify. But their reach is undeniable.
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Looking at the night sky with the naked eye, we can only see an infinitesimal part of what the Universe contains, and the largest part cannot even be "seen". Radio wavelengths have gifted us some of the most fascinating astronomical sources: radio-loud active galactic nuclei in the centers of galaxies, which can produce jets that extend way farther out from the optical galaxy itself.
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The humble mussel and other faunal organisms often play an underappreciated yet important role in protecting and building coastal ecosystems, according to a new study. “As sea levels rise, coastal ecosystems have to adapt and evolve to changing conditions,” says lead author Sinéad Crotty, associate director of science at the Carbon Containment Lab at the Yale University School of the Environment.
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Rigid plastic is very useful, but difficult to recycle. At least it was, until the discovery of so-called vitrimers. Using those vitrimers, Researchers at Wageningen University & Research have laid the foundation for a new type of sustainable, hard plastic that is easy to deform and grows back together on its own. Although researchers only have a prototype so far, in the future it could be an exce
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Technology developments mean that older adults are increasingly at risk of digital exclusion. Moreover, it is more difficult for them to make use of the possibilities offered by technology in countries like Sweden, where the degree of digitalization is high. This is shown in a doctoral thesis on older adults and digitalization by Sofia Alexopoulou.
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Fertilizers are one of the main reasons that we are able to grow enough crops to feed the almost 8 billion humans living on Earth. Modern agriculture depends largely on nitrogen-based fertilizers, which significantly increase the yield of crops. Unfortunately, a great portion of these fertilizers are produced at an industrial level, consuming fossil fuel energy and causing nitrogen pollution.
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Fertilizers are one of the main reasons that we are able to grow enough crops to feed the almost 8 billion humans living on Earth. Modern agriculture depends largely on nitrogen-based fertilizers, which significantly increase the yield of crops. Unfortunately, a great portion of these fertilizers are produced at an industrial level, consuming fossil fuel energy and causing nitrogen pollution.
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Abstract Shifts in the position of the intertropical convergence zone (ITCZ) have great importance for weather, climate, and society. The ITCZ shifts have been extensively studied in current and future warmer climate; however, little is known for its migration in the past on geological time scales. Using an ensemble of climate simulations over the past 540 million years, we show that ITCZ migrati
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Abstract It is known that obstacles can hydrodynamically trap bacteria and synthetic microswimmers in orbits, where the trapping time heavily depends on the swimmer flow field and noise is needed to escape the trap. Here, we use experiments and simulations to investigate the trapping of microrollers by obstacles. Microrollers are rotating particles close to a bottom surface, which have a prescrib
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Abstract Large biases and uncertainties remain in real-time predictions of El Niño–Southern Oscillation (ENSO) using process-based dynamical models; recent advances in data-driven deep learning algorithms provide a promising mean to achieve superior skill in the tropical Pacific sea surface temperature (SST) modeling. Here, a specific self-attention–based neural network model is developed for ENS
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Abstract Mouse esophagus is lined with a stratified epithelium, which is maintained by the constant renewal of unipotent progenitors. In this study, we profiled mouse esophagus by single-cell RNA sequencing and found taste buds specifically in the cervical segment of the esophagus. These taste buds have the same cellular composition as the ones from the tongue but express fewer taste receptor typ
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Abstract All present commercial colors are based on pigments. While such traditional pigment-based colorants offer a commercial platform for large-volume and angle insensitiveness, they are limited by their instability in atmosphere, color fading, and severe environmental toxicity. Commercial exploitation of artificial structural coloration has fallen short due to the lack of design ideas and imp
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Abstract Lightweight and tough engineered materials are often designed with three-dimensional hierarchy and interconnected structural members whose junctions are detrimental to their performance because they serve as stress concentrations for damage accumulation and lower mechanical resilience. We introduce a previously unexplored class of architected materials, whose components are interwoven an
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Abstract Electrical stimulation is a promising method to modulate gastrointestinal disorders. However, conventional stimulators need invasive implantation and removal surgeries associated with risks of infection and secondary injuries. Here, we report a battery-free and deformable electronic esophageal stent for wireless stimulation of the lower esophageal sphincter in a noninvasive fashion. The
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Abstract Messenger RNA (mRNA) lipid nanoparticle (LNP) vaccines have emerged as an effective vaccination strategy. Although currently applied toward viral pathogens, data concerning the platform’s effectiveness against bacterial pathogens are limited. Here, we developed an effective mRNA-LNP vaccine against a lethal bacterial pathogen by optimizing mRNA payload guanine and cytosine content and an
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Abstract The mechanism(s) of how bacteria acquire tolerance and then resistance to antibiotics remains poorly understood. Here, we show that glucose abundance decreases progressively as ampicillin-sensitive strains acquire resistance to ampicillin. The mechanism involves that ampicillin initiates this event via targeting pts promoter and pyruvate dehydrogenase (PDH) to promote glucose transport a
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Abstract Autophagy is a critical process to maintain homeostasis, differentiation, and development. How autophagy is tightly regulated by nutritional changes is poorly understood. Here, we identify chromatin remodeling protein Ino80 and histone variant H2A.Z as the deacetylation targets for histone deacetylase Rpd3L complex and uncover how they regulate autophagy in response to nutrient availabil
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Abstract Ferroptosis has been realized in anticancer drug–induced acute cardiac/kidney injuries (ACI/AKI); however, molecular imaging approach to detect ferroptosis in ACI/AKI is a challenge. We report an artemisinin-based probe (Art-Gd) for contrast-enhanced magnetic resonance imaging of ferroptosis (feMRI) by exploiting the redox-active Fe(II) as a vivid chemical target. In vivo, the Art-Gd pro
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Abstract Lipofuscin is an autofluorescent (AF) pigment formed by lipids and misfolded proteins, which accumulates in postmitotic cells with advanced age. Here, we immunophenotyped microglia in the brain of old C57BL/6 mice (>18 months old) and demonstrate that in comparison to young mice, one-third of old microglia are AF, characterized by profound changes in lipid and iron content, phagocytic ac
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Abstract Ecological conditions in the Amazon rainforests are historically favorable for the transmission of numerous tropical diseases, especially vector-borne diseases. The high diversity of pathogens likely contributes to the strong selective pressures for human survival and reproduction in this region. However, the genetic basis of human adaptation to this complex ecosystem remains unclear. Th
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Abstract Hydroxystilbenes are a class of polyphenolic compounds that behave as lignin monomers participating in radical coupling reactions during the lignification. Here, we report the synthesis and characterization of various artificial copolymers of monolignols and hydroxystilbenes, as well as low-molecular-mass compounds, to obtain the mechanistic insights into their incorporation into the lig
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Abstract Direct air capture (DAC) is important for achieving net-zero greenhouse gas emissions by 2050. However, the ultradilute atmospheric CO 2 concentration (~400 parts per million) poses a formidable hurdle for high CO 2 capture capacities using sorption-desorption processes. Here, we present a Lewis acid-base interaction–derived hybrid sorbent with polyamine-Cu(II) complex enabling over 5.0
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Abstract The polymerase-associated factor 1 complex (PAF1C) is a key, post-initiation transcriptional regulator of both promoter-proximal pausing and productive elongation catalyzed by RNA Pol II and is also involved in transcriptional repression of viral gene expression during human immunodeficiency virus–1 (HIV-1) latency. Using a molecular docking–based compound screen in silico and global seq
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Abstract Acne is an inflammatory skin disease mainly caused by Propionibacterium acnes , which can cause local inflammatory reactions and develop into chronic inflammatory diseases in severe cases. To avoid the use of antibiotics and to effectively treat the site of acne, we report a sodium hyaluronate microneedle patch that mediates the transdermal delivery of ultrasound-responsive nanoparticles
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Abstract Targeted transfection of siRNA to preosteoclasts features the potential of anti-osteoporosis, yet challenge arises from the development of satisfied delivery vehicles. Here, we design a rational core-shell nanoparticle (NP) composed of cationic and responsive core for controlled load and release of small interfering RNA (siRNA) and compatible polyethylene glycol shell modified with alend
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Abstract Clinical translation of stem cell therapies for heart disease requires electrical integration of transplanted cardiomyocytes. Generation of electrically matured human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) is critical for electrical integration. Here, we found that hiPSC-derived endothelial cells (hiPSC-ECs) promoted the expression of selected maturation markers
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Abstract Late recurrences of breast cancer are hypothesized to arise from disseminated tumor cells (DTCs) that reactivate after dormancy and occur most frequently with estrogen receptor–positive (ER + ) breast cancer cells (BCCs) in bone marrow (BM). Interactions between the BM niche and BCCs are thought to play a pivotal role in recurrence, and relevant model systems are needed for mechanistic i
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Abstract Mechanical stresses across different length scales play a fundamental role in understanding biological systems’ functions and engineering soft machines and devices. However, it is challenging to noninvasively probe local mechanical stresses in situ, particularly when the mechanical properties are unknown. We propose an acoustoelastic imaging–based method to infer the local stresses in so
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Abstract Shifting the focus of attention without moving the eyes poses challenges for signal coding in visual cortex in terms of spatial resolution, signal routing, and cross-talk. Little is known how these problems are solved during focus shifts. Here, we analyze the spatiotemporal dynamic of neuromagnetic activity in human visual cortex as a function of the size and number of focus shifts in vi
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Abstract Tumors use multiple mechanisms to actively exclude immune cells involved in antitumor immunity. Strategies to overcome these exclusion signals remain limited due to an inability to target therapeutics specifically to the tumor. Synthetic biology enables engineering of cells and microbes for tumor-localized delivery of therapeutic candidates previously unavailable using conventional syste
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Ships are the main modes of transport for global trade as they are efficient and effective. Improving the aerodynamic performance of ship could reduce fuel consumption and improve speed, further improving the economics of shipping. Recently, researchers from have demonstrated that flat plate bow covers on ships can reduce overall wind drag in ships by nearly 40%, which could lead to enormous fuel
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New research has found that olive fruit water, a by-product typically thrown away during olive oil production, could have exercise benefits. The study tested olive fruit water during exercise and found it had positive effects on several key markers of running performance.
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The success of shifting to remote work depends on a company’s flexibility to adjust to individual employees and the technology available to them, according to a new study. While more businesses continue to shift to remote work, some well-known CEOs remain steadfast against the movement. Offering remote work as an option to employees can serve as a powerful recruitment tool and one that can be eas
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Galaxy Brain Worried about the plausible BS — also known as machine " hallucination " — that Large Language Models (LLMs) are known for spitting out? Not to fear. According to one high-profile AI entrepreneur, machine hallucination doesn't exist… but alternate realities apparently do. "LLMs don't hallucinate," Stability.ai CEO Emad Mostaque — whose buzzy AI firm is in the throes of a fundraisin
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Fed Up Feds You'd better hope Tesla's Full Self-Driving feature is all CEO Elon Musk makes it out to be, because as a Tesla driver, you may suddenly find yourself deprived of a steering wheel while on the road. Following two accounts of Tesla vehicles exhibiting such a shocking lack of quality control, the National Highway Traffic Safety Administration (NHTSA) is now stepping in to launch an inve
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Relatively minor support with the application process is enough to help families with lower educational attainment secure childcare. A new study shows that mothers subsequently pursue more working hours and that the earnings gap between mothers and fathers becomes narrower. A causal link has now been demonstrated for the first time in the case of women with a relatively low school certificate who
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It can be tough on our bodies when we spring forward to daylight saving time. A sleep expert offers strategies to help you adjust. There are two kinds of people in this world: Those who love daylight saving time, and those who don’t . University of California, Davis Health sleep medicine expert Heinrich Gompf is not a big fan of the clock change—or at least not the way we currently do it in the U
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Gender diversity experts at the University of South Australia are urging governments to rethink their approach to gender targets as new research by UniSA scholars shows that they do not lead to expected improvements in gender equity for women in leadership. The study is published in the Australian Journal of Public Administration.
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A new global study, which takes a gender-sensitive approach, has found that a mother's educational status plays an increasingly important role in shaping their children's educational status, while the importance of the father's educational status has declined.
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Our solar system is suspended in a delicate balance of massive forces. Introduce a new terrestrial planet into that equation between Mars and Jupiter, and it could jettison the Earth out of the solar system and end life as we know it, according to a new study published in The Planetary Science Journal , findings that could help us identify other Earth-like exoplanets that can harbor life. Why Mar
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This week marked the passing of one month since a 7.8-magnitude earthquake struck near the Turkish city of Gaziantep on February 6, followed by dozens of powerful aftershocks. More than 50,000 deaths have been reported across southern Turkey and northwestern Syria. Rescue and recovery efforts have wound down, and the work of removing rubble and demolishing damaged buildings has begun. The United
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What if, in the end, we are done in not by intercontinental ballistic missiles or climate change, not by microscopic pathogens or a mountain-size meteor, but by … text? Simple, plain, unadorned text, but in quantities so immense as to be all but unimaginable—a tsunami of text swept into a self-perpetuating cataract of content that makes it functionally impossible to reliably communicate in any di
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Photographs by Ryan Pfluger A rnold Schwarzenegger nearly killed me. I had joined him one morning as he rushed through his daily routine. Schwarzenegger gets up by six. He makes coffee, putters around, feeds Whiskey (his miniature horse) and Lulu (his miniature donkey), shovels their overnight manure into a barrel, drinks his coffee, checks his email, and maybe plays a quick game of chess online.
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‘Cleanup is futile’ if production continues at current rate, amid rapid rise in marine pollution An unprecedented rise in plastic pollution has been uncovered by scientists, who have calculated that more than 170tn plastic particles are afloat in the oceans. They have called for a reduction in the production of plastics, warning that “cleanup is futile” if they continue to be pumped into the envi
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When physicists recently steered a tiny microparticle toward a cylindrical obstacle, they expected one of two outcomes to occur. The particle would either collide into the obstacle or sail around it. The particle, however, did neither.
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A new analysis of crime statistics near hundreds of places of worship in Washington, D.C., shows that these sites are associated with higher levels of violent and property crime—even after accounting for other factors commonly linked with crime. James Wo of the University of Iowa, U.S., presents these findings in the open-access journal PLOS ONE on March 8, 2023.
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Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and in
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While the crowds swarm around Old Faithful to wait for its next eruption, a little pool just north of Yellowstone National Park's most famous geyser is quietly showing off its own unique activity, also at more-or-less regular showtimes. Instead of erupting in a towering geyser, though, Doublet Pool cranks up the bass every 20 to 30 minutes by thumping. The water vibrates and the ground shakes.
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NASA recently announced the discovery of a new, Earth-sized planet in the habitable zone of a nearby star called TOI-700. We are two of the astronomers who led the discovery of this planet, called TOI-700 e. TOI-700 e is just over 100 light years from Earth—too far away for humans to visit—but we do know that it is similar in size to the Earth, likely rocky in composition and could potentially sup
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About one-fifth of California’s Sierra Nevada conifer forests are a mismatch for the region’s warming weather, a new study shows. The study shows how these “zombie forests” are temporarily cheating death, likely to be replaced with tree species better adapted to the climate after one of the state’s increasingly frequent catastrophic wildfires. “Forest and fire managers need to know where their li
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According to the IEA , there are currently 18 direct air capture plants in operation around the world. They’re located in Europe, Canada, or the US, and most of them use the CO2 for commercial purposes, with a couple storing it away for all eternity. Direct air capture (DAC) is a controversial technology, with opponents citing its high cost and energy usage. Indeed, when you consider the amount o
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Researchers have identified a way to treat the area surrounding breast tumors that have spread to bone so that such tumors become vulnerable to attack by the body's immune system. When the researchers boosted the activity of certain immune cells, called T cells and macrophages, these immune cells worked together to clear metastatic breast tumors that had spread to the bones of mice.
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Scientists have made an important breakthrough in understanding what goes wrong in our bodies during the progression of inflammatory diseases and — in doing so — unearthed a potential new therapeutic target. The scientists have found that an enzyme called fumarate hydratase is repressed in macrophages, a frontline inflammatory cell type implicated in a range of diseases including lupus, arthriti
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A pilot trial tested the nasal administration of the drug Foralumab, an anti-CD3 monoclonal antibody. Investigators found evidence that the drug dampened the inflammatory T cell response and decreased lung inflammation in patients with COVID-19. Further analysis showed the same gene expression modulation in patients with multiple sclerosis, who experienced decreased brain inflammation, suggesting
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The Third International Summit on Human Genome Editing, a three-day conference organized by the Royal Society, the U.K. Academy of Medical Sciences, the U.S. National Academies of Sciences and Medicine and The World Academy of Sciences, was held this week in March 2023 at the Francis Crick Institute in London. Scientists, bioethicists, physicians, patients and others gathered to discuss the latest
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The Third International Summit on Human Genome Editing, a three-day conference organized by the Royal Society, the U.K. Academy of Medical Sciences, the U.S. National Academies of Sciences and Medicine and The World Academy of Sciences, was held this week in March 2023 at the Francis Crick Institute in London. Scientists, bioethicists, physicians, patients and others gathered to discuss the latest
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A large international team of space scientists has discovered that the detection of an exoplanet orbiting the star 40 Eridani was made in error. The group has published a paper on the arXiv pre-print server describing their reanalysis of the star and its exoplanet and how they discovered the error.
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One Falls, Another Rises As language-modeling AIs continue their rise to dominance, a new-old victim to the tech might be emerging: voice assistants. According to Microsoft CEO Satya Nadella, that is. As the scope and impact of Amazon's recent layoffs — which reportedly hit Amazon's Alexa division quite seriously — come further into focus, The Financial Times has revealed that in an interview las
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Stark Warning It feels safe to say that John Reed Stark, a former attorney for the US Securities and Exchange Commission, is not a fan of the cryptocurrency firm Binance . The crypto exchange — now the world's largest in terms of trading volume, as a direct result of former rival FTX's spectacular November collapse into bankruptcy — has faced mounting controversy in recent days as the result of a
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People who start playing tackle football at an early age or play for more than 11 years may have less white matter in their brain, potentially leading to poor impulse control and thinking problems, researchers report. The degenerative brain disease known as CTE, or chronic traumatic encephalopathy, has become a specter haunting football. “Just because you aren’t diagnosed with CTE doesn’t mean th
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Could robotic parents with their own set of DNA for the child could exist?, we’ve developed artificial wombs and soon designer babies so would it be possible to have a robotic parent? submitted by /u/malum68 [link] [comments]
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Imagine for a moment, that we are on a safari watching a giraffe graze. After looking away for a second, we then see the animal lower its head and sit down. But, we wonder, what happened in the meantime? Computer scientists have found a way to encode an animal's pose and appearance in order to show the intermediate motions that are statistically likely to have taken place.
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Do cesarean-born babies miss out on essential microbes? New evidence suggests that the answer may be 'no.' Researchers report that mothers are able to transfer microbes to their babies via alternative, compensatory routes. While cesarean-born babies do receive less of their mother's gut microbiome during birth, they make up for this by drinking their mother's microbes in breastmilk.
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In a historic achievement, researchers have created a superconducting material at both a temperature and pressure low enough for practical applications. 'With this material, the dawn of ambient superconductivity and applied technologies has arrived,' according to a team of mechanical engineers and physicists.
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Hello, hope your week is going well! If you have some time and are a non-student adult (18+ in age), please help us by taking this survey ( https://cornell.ca1.qualtrics.com/jfe/form/SV_5dvDESJ2ljohrZI ) about what you think, especially on health decision making. The survey takes about 35 minutes or less. We respect and want to hear ALL perspectives. Thank you very much for your help! This survey
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Bees—honey bees and wild bees alike—are in trouble. Wild bee populations may have declined by 23% across the United States, according to one 2015 study that modeled their abundance between 2008 and 2013. Another study found that 25% fewer bee species were spotted globally. Managed honey bees, on the other hand, have been seeing unsustainable colony losses for more than a decade.
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How do cells work in a normal state? How do they change when they cause disease? Do they react as desired to new drugs? Nowadays, anyone seeking answers to these—and other related—questions in the laboratory can hardly do without a special technique: single-cell RNA sequencing, or "scRNA-seq" for short. This technique provides an accurate picture of gene expression in a single cell at a specific p
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Bees—honey bees and wild bees alike—are in trouble. Wild bee populations may have declined by 23% across the United States, according to one 2015 study that modeled their abundance between 2008 and 2013. Another study found that 25% fewer bee species were spotted globally. Managed honey bees, on the other hand, have been seeing unsustainable colony losses for more than a decade.
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An international team of scientists led by Tomáš Pluskal from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) has introduced a new generation of software that enables scientists to analyze large volumes of data from mass spectrometry, a technique that separates chemicals by their weights.
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How do cells work in a normal state? How do they change when they cause disease? Do they react as desired to new drugs? Nowadays, anyone seeking answers to these—and other related—questions in the laboratory can hardly do without a special technique: single-cell RNA sequencing, or "scRNA-seq" for short. This technique provides an accurate picture of gene expression in a single cell at a specific p
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A wildfire can pump smoke up into the stratosphere, where the particles drift for over a year. A new MIT study has found that while suspended there these particles can trigger chemical reactions that erode the protective ozone layer shielding the Earth from the sun's damaging ultraviolet radiation.
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In July 2021, Kew in London experienced a month's rain in just three hours. Across the city, tube lines were suspended and stations closed as London experienced its wettest day in decades and flash floods broke out. Just under two weeks later, it happened again: intense downpours led to widespread disruption, including the flooding of two London hospitals.
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The faba bean genome, which at 13 billion bases is more than four times the size of the human genome, has been sequenced for the first time and is published in Nature. This is an extraordinary technical achievement and crucial to efforts to breed beans with optimum nutritional content and sustainability of production.
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Gold disc represents first solid evidence of main Norse god being worshipped in fifth century Scandinavian scientists have identified the oldest known inscription referencing the Norse god Odin on part of a gold disc unearthed in western Denmark. Lisbeth Imer, a runologist with the National Museum in Copenhagen, said the inscription represented the first solid evidence of Odin being worshipped as
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A new global study, which takes a gender-sensitive approach, has found that a mother's educational status plays an increasingly important role in shaping their children's educational status, while the importance of the father's educational status has declined. Education expansion was expected to create greater social mobility around the world, but new global evidence from Lancaster University and
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Say Sorry After dragging an ex-Twitter employee and then deleting some of the evidence , Elon Musk has apologized to Haraldur Thorleifsson after disparaging him publicly in front of his over 100 million followers. The entire debacle began earlier this week when Thorleifsson, whose Ueno creative agency was acquired by Twitter in 2021 , tweeted at Musk asking if he'd been let go from the company be
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One of the great scientific projects of our time is the Search for Extraterrestrial Intelligence or SETI — the hunt for evidence of technologically advanced civilizations elsewhere in the galaxy. The current manifestation of this endeavor is the Breakthrough Listen Initiative, which uses radio telescopes to look for signals that cannot have a terrestrial origin. The big challenge in this effort is
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Tesla has shot to the top of the auto industry on the strength of its battery technology, but it still gets some basic “car things” wrong. The National Highway Traffic Safety Administration (NHTSA) has opened yet another investigation into the company following two reports of steering wheels coming off while being driven. The NHTSA says the inquiry includes 120,089 Model Y vehicles produced in th
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Sunflower sea stars may offer a way to keep hungry urchin populations in check and possibly help restore kelp forests, a new study shows. Your average sunflower sea star can munch through almost five purple sea urchins in a week, and they don’t seem to be picky about the quality of their food, the researchers report. That’s good news—and valuable data—for efforts to reintroduce these now-endanger
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A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response. Mitochondria are functional units of our cells that fulfill important tasks, i.e. chemical reactions, for the functioning of the cell. One of these tasks is the production of energy that is necessary for cell growth and reproduction.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-022-05675-0 Information from natural protein libraries was extracted and used to design heteropolymer ensembles as mixtures of disordered, partially folded and folded proteins, providing valuable guiding principles to synthetically realize protein properties.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-023-05781-7 Structural and biochemical studies of the Mycobacterium smegmatis hydrogenase Huc provides insights into how [NiFe] hydrogenases oxidize trace amounts of atmospheric hydrogen and transfer the electrons liberated via quinone transport.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-023-05789-z Biochemical and molecular dynamics studies show that the third intracellular loop of G protein-coupled receptors autoregulates the receptor activity and tunes the signalling specificity by controlling access to the G protein-binding site.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-023-05787-1 Effective anti-PD-1 immunotherapy is associated with the presence of polyclonal CD8+ T cells in the tumour and blood specific for a limited number of immunodominant mutations, which are recurrently recognized over time.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-023-05742-0 A nitrogen-doped lutetium hydride was synthesized under high-pressure high-temperature conditions and, following full recoverability, examination along compression pathways showed evidence of superconductivity at room temperature and near-ambient pressures.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-023-05770-w Fumarate metabolism regulates the innate immune response through a mechanism in which high levels of fumarate result in the generation of mitochondrial-derived vesicles and the release of mitochondrial DNA into the cytosol, which activates inflammatory pathways.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-022-05683-0 Comparison of model simulations with atmospheric observations from the Southern Hemisphere mid-latitudes following the 2020 Australian wildfires shows that the wildfire aerosol composition promotes stratospheric chlorine and ozone depletion chemistry.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-023-05788-0 A study finds T cells in areas of tau, not amyloid, pathology in Alzheimer’s disease brain and mouse models, with their presence correlating with neuronal loss and their depletion, or that of microglia, preventing neurodegeneration and cognitive decline.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-023-05743-z By analysing atomic-scale Pb–Pb Josephson junctions including magnetic atoms in a scanning tunnelling microscope, a new mechanism for diode behaviour is demonstrated, opening up new paths to tune their properties by means of single-atom manipulation.
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Nature, Published online: 08 March 2023; doi:10.1038/s41586-023-05802-5 A technique to detect the release of N-terminal fragments of Drosophila adhesion G-protein-coupled receptors (aGPCRs) provides insight into the dissociation of aGPCRs, and shows that receptor autoproteolysis enables non-cell-autonomous activity of aGPCRs in the brain.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00311-x The compatibility of a material with its environment is important for real-world applications. A framework has been developed to translate the amino-acid sequence of segments of proteins into engineered synthetic polymers, enabling the creation of ensembles of polymers with properties matching those of mixtures of proteins.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00599-9 A hydrogen-rich compound has taken the lead in the race for a material that can conduct electricity with zero resistance at room temperature and ambient pressure — the conditions required for many technological applications.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00425-2 A group of neuronal cells in the airways have been shown to detect chemicals, called prostaglandins, that are produced by immune cells during infection with a respiratory virus. Once stimulated, the neurons relay this signal to the brain. Mice in which the function of these neurons is impaired show less sickness behaviour aft
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00598-w Unexpected smoke-particle chemistry is shown to be the link between intense wildfires and stratospheric ozone loss. As the climate changes, more-frequent and more-intense fires might delay the recovery of the stratospheric ozone layer.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00461-y A high-quality reference genome has been generated for the broad bean (also known as the faba or fava bean). The sequence could be used to identify ways to increase yield, improve pest resistance and more.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00600-5 An analysis of mice carrying the protein tau — a hallmark of Alzheimer’s disease — reveals that immune cells collaborate to drive tau-mediated neurodegeneration, and that drugs already in use in the clinic can combat this decline.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00596-y Cellular organelles called mitochondria contain their own DNA and RNA. The molecule fumarate has now been found to trigger the release of these nucleic acids into the cytosol, aberrantly activating inflammation.
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A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response. Mitochondria are functional units of our cells that fulfill important tasks, i.e. chemical reactions, for the functioning of the cell. One of these tasks is the production of energy that is necessary for cell growth and reproduction.
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Creation of mammal with two biological fathers could pave way for new fertility treatments in humans Scientists have created mice with two biological fathers by generating eggs from male cells, a development that opens up radical new possibilities for reproduction. The advance could ultimately pave the way for treatments for severe forms of infertility, as well as raising the tantalising prospect
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What’s the most impressive fossil you ever saw? For most people — those who aren’t paleontologists — the answer would probably veer towards the A-list of ancient creatures: dinosaurs, pterosaurs and other long-extinct megafauna whose size and majesty have made them the showpieces of museums and the inspiration of film franchises for decades. But what if someone told you that you’ve been overlookin
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It sounds like a party trick: Add water to the clear, licorice-flavored ouzo liquor, and watch it turn cloudy. This 'ouzo effect' is an example of an easy way to make highly stable emulsions — or mixtures of liquids that don't like being together, like vinaigrettes — but nobody has yet fully understood how it works. Now, researchers report that the secret may lie in the unique structure of the e
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A team of researchers at the University of Rochester claim s to have achieved a "historic" breakthrough by creating a superconducting material at both room temperature and feasible levels of pressure — something that could potentially lay the groundwork for the mass adoption of the tech. "With this material, the dawn of ambient superconductivity and applied technologies has arrived," said Univers
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Last week, the leading American robotics firm Boston Dynamics made its official Paris Fashion Week debut , deploying its viral robodog, Spot , on French fashion label Coperni's runway. Yes, that Spot, the one that can dance , jump rope , and — oh yeah — is already being used by the US military to, among other things, patrol America's Southern border . To the credit of both Coperni — the same folk
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A research team from the Hong Kong University of Science and Technology (HKUST) has developed the world's most productive chemical synthesis, which could yield antibiotic anthracimycin and anthracimycin B that is 63 times more prolific than the current method. The breakthrough greatly advances the development of anthracimycin-based antibiotics to combat deadly bacteria infections caused by antibio
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PET—the plastic used to make bottles, for example—is ubiquitous in our natural environment. In a joint study, scientists from Leipzig University and the Helmholtz Centre for Environmental Research (UFZ) investigated the negative effects that tiny plastic PET particles can have on the metabolism and development of an organism. Their findings have now been published in the journal Scientific Reports
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In a packed talk on Tuesday afternoon at the American Physical Society’s annual March meeting in Las Vegas, Ranga Dias, a physicist at the University of Rochester, announced that he and his team had achieved a century-old dream of the field: a superconductor that works at room temperature and near-room pressure. Interest was so intense in the presentation that security personnel stopped entry to.
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New twist in debate over whether bryozoans cropped up during Cambrian explosion or later A group of fossils previously thought to be of marine creatures may not be as ancient as first thought and could actually be of a type of seaweed, a study has found. Researchers say the potential of evolution to throw up novel body plans among animals did not end with the Cambrian explosion more than 500m yea
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A research team from the Hong Kong University of Science and Technology (HKUST) has developed the world's most productive chemical synthesis, which could yield antibiotic anthracimycin and anthracimycin B that is 63 times more prolific than the current method. The breakthrough greatly advances the development of anthracimycin-based antibiotics to combat deadly bacteria infections caused by antibio
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Scientists studying a nearby protostar have detected the presence of water in its circumstellar disk. The new observations made with the Atacama Large Millimeter/submillimeter Array (ALMA) mark the first detection of water being inherited into a protoplanetary disk without significant changes to its composition. These results further suggest that the water in our solar system formed billions of ye
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Sea ice in Antarctica shrank to the smallest area on record in February for the second year in a row, continuing a decade-long decline, the European Union's climate monitoring service said Tuesday.
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PET—the plastic used to make bottles, for example—is ubiquitous in our natural environment. In a joint study, scientists from Leipzig University and the Helmholtz Centre for Environmental Research (UFZ) investigated the negative effects that tiny plastic PET particles can have on the metabolism and development of an organism. Their findings have now been published in the journal Scientific Reports
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Smart toilets could detect disease early, but squeamishness and privacy concerns could impede their use. The smart toilet has the technology to interpret the data that’s dripped, dumped, or otherwise flushed to glean insights into health. Urine flow a bit light? That might indicate a problem with the prostate. Blood in the urine? That suggests a urinary tract or kidney infection. Different shapes
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Habitat split is a common event in the environment that occurs when different classes of natural habitats, such as forests and water, are disconnected. As a consequence, the movement of organisms between these environments is disrupted, which can be particularly harmful to species with both an aquatic and terrestrial life stage, like amphibians.
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A small team of psychologists from Oklahoma State University, the University of Texas at Austin and Hamilton College, all in the U.S., has found through a survey that people generally want their friends to be nice to them but also want their friends to be vicious in dealings with their enemies. The results are published in the journal Evolution and Human Behavior.
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The lockdowns at the beginning of COVID-19 pandemic reduced the spread of infection by an estimated 56%, a recent study has found. If all governors did not issue any lockdowns until April 23, 2020, the number of cases would have been five times higher by April 30, 2020, the study asserts.
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Habitat split is a common event in the environment that occurs when different classes of natural habitats, such as forests and water, are disconnected. As a consequence, the movement of organisms between these environments is disrupted, which can be particularly harmful to species with both an aquatic and terrestrial life stage, like amphibians.
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The oceans soak up carbon dioxide emissions, helping to limit global warming—but intense warming in the future could lessen that ability, leading to even more intense warming, scientists warn. For a new study, the researchers analyzed a climate simulation configured to a worst-case emissions scenario and found that the oceans’ ability to soak up carbon dioxide would peak by 2100, becoming only ha
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Midway through the Roman empire, an unnamed court official who answered to Emperor Tiberius stepped on a fish and changed the course of medical history. The electric torpedo fish, common to the Mediterranean, shocked the administrator, who noticed afterward that the gout pain in his leg had greatly subsided. Word reached Roman physician Scribonius Largus, who then famously recommended the shocks,
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Whether you're a jet setter or a nervous flier, if you sit and think about it hard enough, the fact that we have built machines that soar into the sky for thousands of miles with hundreds of people aboard is baffling. Even though it's common to have flight jitters — flying is one of the safest modes of transportation. Wrapping our heads around flying can actually be a bit challenging; however, Pro
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Black holes are absolutely silent, as they are creatures of pure gravity. But while black holes produce no sound of their own, they can generate sound waves in their environment. A Simple Black Hole Black holes are surprisingly simple objects. In the general theory of relativity, which is the framework we use to understand all things gravity, you only need three numbers to completely and totally d
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00659-0 Better prospects are needed in universities and industry to make the most of valuable talent.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00666-1 The government’s university endowment scheme is a ‘big moment’ for Japanese science, says Takahiro Ueyama.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00669-y A description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.
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Nature, Published online: 02 March 2023; doi:10.1038/d41586-023-00619-8 Widely used polymers called polyurethanes are difficult to recycle, but a chemical strategy allows them to be easily broken down into useful components.
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W hen I was in school , American history was taught as a series of triumphs over wrongs that belonged to the past. Slavery was evil, but the Civil War ended it; then the civil-rights movement ended segregation. The vote was extended to more and more Americans—starting with white men, then women, Black people, and finally even 18-year-olds—thus fulfilling the promise of democracy. There was no ato
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Why is the United States so exceptionally violent? In 2021, for example, more than 26,000 Americans were murdered—a homicide rate that would be unthinkable in the affluent market democracies of Europe and East Asia. There are any number of explanations for America’s outlier status, including deep-seated cultural characteristics and the prevalence of firearms. But we suggest a different, more pars
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Former NSYNC member Lance Bass grew up dreaming of becoming an astronaut and was planning on becoming an engineer — until a call from Justin Timberlake launched him on a very different trajectory, that is. But for a six-month hiatus from the legendary boy band in 2002 — which would later turn into the disbandment of the group — Bass dived straight back into that childhood dream. He spent that sum
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The urgency of the global transition to a net-zero economy, focused on solutions that enable the reduction of greenhouse gas emissions, cannot be overstated. As both the engine of global economic growth and substantial emissions generator, industry has a unique responsibility and opportunity to lead this process. And while the energy and petrochemicals sectors have understandably been a central f
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Researchers at Empa, ETH Zurich and the Politecnico di Milano are developing a new type of computer component that is more powerful and easier to manufacture than its predecessors. Inspired by the human brain, it is designed to process large amounts of data fast and in an energy-efficient way.
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(Credit: NASA) We know by now that climate change can’t be ignored . Now and then, though, we stumble upon a new reason to embrace climate change mitigation techniques with a renewed sense of urgency. This might be one of those times. An international team of researchers from the United States, United Kingdom, and Germany has found that positive feedback loops are actively exacerbating global cli
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Using NASA's Chandra X-ray observatory, astronomers have performed deep X-ray observations of a nearby active galaxy known as NGC 5728 and its active galactic nucleus (AGN). Results of the observational campaign, published March 1 on the pre-print server arXiv, deliver important information regarding the properties of this AGN and the emission from it.
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At an excavation site in northern Mexico, BYU archaeology students and professors recently discovered artifacts that have been buried for 1,000 years, including pottery sherds, hammer stones, maize kernels and—intriguing at a location 250 miles inland—a shell bead from the Pacific Ocean.
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Climate change is a global emergency challenging scientists, engineers, and industry experts from a wide array of disciplines to use their knowledge and skills in pursuit of solutions to protect our planet.
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Researchers from Fudan University, China Europe International Business School, and Peking University published a new Journal of Marketing article that examines how marketers can use different messaging to persuade individuals to contribute to a collective goal. The study addresses the specific question of the type of message—fact-based vs. affected-based—that is more effective in eliciting partici
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When researchers increased the heart rates of mice, the animals showed more anxious behavior. Standing on the edge of a precipice, losing your way in a dark forest, or running into a crush will quicken your pulse—a physical consequence of the anxiety you experience. The new findings offer evidence of the reverse: A faster heart rate can generate anxiety. When researchers artificially boosted an a
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For family members unexpectedly taking care of a relative's child during the opioid crisis, it can be difficult to navigate the legal waters of assuming custody. The process may be easier—and come with more support—if these caregivers have personal connections to local resource institutions, according to a study conducted by a Penn State faculty member.
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Kvinnor har bidragit till många samhällsförändringar, men deras insatser kan ha fallit i glömska. Det ville forskare ändra på genom att låta 2000 historiska kvinnor ta plats i ett lexikon. Inlägget dök först upp på forskning.se .
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It sounds like a party trick: Add water to the clear, licorice-flavored ouzo liquor, and watch it turn cloudy. This "ouzo effect" is an example of an easy way to make highly stable emulsions—or mixtures of liquids that don't like being together, like vinaigrettes—but nobody has yet fully understood how it works. Now, researchers report in ACS Central Science that the secret may lie in the unique s
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In places across the U.S., tree cover is shrinking—forests are burned by wildfires on the West Coast and drowned by rising sea levels along the East. From the ground, it's hard to assess the scale of the losses and the effects disappearing trees have on atmospheric carbon dioxide levels and climate change.
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Mary L. Rigdon, director of the University of Arizona Center for the Philosophy of Freedom and an associate professor in the Department of Political Economy and Moral Science, has spent years studying gender competitiveness and women's equity. Her work challenges traditional stereotypes and makes a compelling business and ethical case to close the wage gap between men and women.
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Short-distance migration, which accounts for the vast majority of migratory movements in the world, is crucial for climate change adaptation, according to new research. Contrary to common assumptions, most migratory movements are people moving short distances, largely due to economic, social and environmental factors, such as climate change.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00647-4 Innovative technology and a class of drugs called SGLT2 inhibitors could help more people with this common condition.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00649-2 Policies that prevent undocumented immigrants in the United States from receiving a donated organ are not only cruel and unfair, but also fail the cost-effectiveness test.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00650-9 When a transplant is out of reach, kidney failure leaves those without access to high-quality health care with few options.
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So I think it goes without saying that decentralized technology has utility that can improve the way some industries function. With the purpose decentralization serves coupled with your own experience, which industries could be overtaken by decentralized technology? submitted by /u/2anapqc [link] [comments]
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G rowing up as the adopted Korean daughter of white parents in a predominantly white community, I discovered early on that my presence was often a surprise, a question to which others expected answers. I soon learned how to respond to the curiosity of teachers at school, strangers at Sears, friends who had finally worked up the nerve to ask Who are your real parents? Why did they give you up? Are
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Billions of sea anemones adorn the bottom of the Earth's oceans — yet they are among the rarest of fossils because their squishy bodies lack easily fossilized hard parts. Now a team of paleontologists has discovered that countless sea anemone fossils have been hiding in plain sight for nearly 50 years. It turns out that fossils long-interpreted as jellyfish were anemones. To do so, a team of scie
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Humans may have arrived in North America earlier than once thought and encountered previously unrecognized challenges, according to new climate research. Jon Erlandson, an archaeologist and director of the University of Oregon Museum of Natural and Cultural History, helped develop the “kelp highway” hypothesis, which proposed that the first Americans followed a Pacific Coast route from Northeast
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This is today’s edition of The Download , our weekday newsletter that provides a daily dose of what’s going on in the world of technology. Sam Altman invested $180 million into a company trying to delay death When a startup called Retro Biosciences eased out of stealth mode in mid-2022, it announced it had secured $180 million to bankroll an audacious mission: to add 10 years to the average human
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This is Work in Progress, a newsletter by Derek Thompson about work, technology, and how to solve some of America’s biggest problems. Sign up here to get it every week . L ast week, Columbia University became the latest school to announce that it would no longer require SAT or ACT scores for undergraduate admissions. The school’s decision was “rooted in the belief that students are dynamic, multi
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Sign up for The Weekly Planet, The Atlantic’ s newsletter about living through climate change, here. For most people, discovering a frog living in your fence post would make you feel either kind of creeped out or kind of charmed. For one guy in Australia, it was a challenge: He decided to make it the sweetest pad possible. In a now-viral two-minute TikTok video , he designs and 3-D-prints his fro
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When Kate Winslet won an Academy Award in 2009, she started her acceptance speech by recounting breathlessly how she had practiced that moment in the bathroom mirror as a child, with a shampoo bottle as a prop statuette. “Well, it’s not a shampoo bottle now!” she said, as if trying to convince herself. The actor then sought out her father in the crowd by asking him to whistle, whipped toward the
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Den snabba tekniska utvecklingen ökar risken för att äldre hamnar på efterkälken. Det är extra tydligt i Sverige där allt mer i vardagslivet kräver digital kompetens, visar en avhandling som jämfört äldres situation i Sverige och Grekland. Inlägget dök först upp på forskning.se .
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Nature, Published online: 07 March 2023; doi:10.1038/d41586-023-00695-w Fifteen ESA missions are stalled after Vega rockets were grounded because of a launch failure. Plus, astrobiologists train AI to find life on Mars and what the earthquake in Turkey tells us about the science of seismic forecasting.
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Image: NASA (Credit: NASA) For untold eons, a comet has been drifting through space, paying a visit to Earth every 80,000 years or so. This time, astronomers were on the lookout and gave it a name: ​​C/2023 A3 (Tsuchinshan-ATLAS). It’s a clunky moniker, but you ought to remember it. Next year, this object could become one of the brightest in the night sky as it passes close to Earth. Astronomers
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Billions of sea anemones adorn the bottom of the Earth's oceans—yet they are among the rarest of fossils because their squishy bodies lack easily fossilized hard parts. Now a team of paleontologists has discovered that countless sea anemone fossils have been hiding in plain sight for nearly 50 years.
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BGI Group, which is said to have made multiple attempts to hack into Genomics England, was given £11m testing contract in 2021 UK politics live – latest news updates China’s leading genomics research company was given a Covid testing contract in the UK despite ministers knowing it had repeatedly sought to hack into the NHS’s genetic datacentre, a government minister has said. The BGI Group was ma
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China Report is MIT Technology Review’s newsletter about technology developments in China. Sign up to receive it in your inbox every Tuesday. As I often say, the American people and the Chinese people have much more in common than either side likes to admit. For example, take the shared concern about how much time children and teenagers are spending on TikTok (or its Chinese domestic version, Dou
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It was déjà vu last month when a university in Belgium stripped Egyptian physician Hatem Abu Hashim of his doctorate after he was found to have fabricated data in his thesis. Just weeks earlier, another Egyptian doctor, Ahmed Badawy, lost the PhD degree he had earned at a Dutch university in 2008. Abu Hashim and Badawy are both professors in the department of obstetrics and gynecology at Mansoura
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Nature Communications, Published online: 08 March 2023; doi:10.1038/s41467-023-36705-8 Living things rely on extremely sensitive molecular circuits. Here, authors uncover a universal structural limit on kinetic scheme sensitivity, with implications for gene regulation &the functions of condensates.
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Nature Communications, Published online: 08 March 2023; doi:10.1038/s41467-023-35908-3 Mutations in tRNA ligases, essential components of the translational machinery, are associated with Charcot-Marie-Tooth peripheral neuropathy, but the mechanistic details are not known. The authors report that the tyrosyl-tRNA synthetase is an evolutionary-conserved F-actin organizer, and dysregulation of this
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When a startup called Retro Biosciences eased out of stealth mode in mid-2022, it announced it had secured $180 million to bankroll an audacious mission: to add 10 years to the average human life span . It had set up its headquarters in a raw warehouse space near San Francisco just the year before, bolting shipping containers to the concrete floor to quickly make lab space for the scientists who
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Considering the growing number of apps which are operating on psychophysiology I've created simple, lightweight lib for calculating heart rate variability for flutter apps: https://github.com/Przemekeke/flutter_hrv The idea is to create a framework/package such as neurokit2 but integrated with smart devices in order to work on data collected by devices directly on that device. Any thoughts or com
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00641-w As generative AI models grow larger and more powerful, some scientists advocate for leaner, more energy-efficient systems.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00670-5 International Women’s Day can serve to bring hope, highlight progress, and inspire research communities to continue their efforts to push hard for true gender quality.
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Nature, Published online: 08 March 2023; doi:10.1038/d41586-023-00692-z Despite facing sociocultural and political barriers, vertebrate palaeontologist Khalafallah Salih returned home to train the next generation.
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In January 2022, Canada became among the few countries to explicitly offer psychedelics to patients with serious or life-threatening conditions. The policy change was supposed to create a fast-track for the drugs, which are still experimental. But critics say too many people are being left behind.
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Nature Communications, Published online: 08 March 2023; doi:10.1038/s41467-023-36805-5 How the brain builds memories from the complex, dynamic experiences that make up everyday life remains poorly understood. Here, the authors show that memories for lifelike events are supported by stable representations of people, contexts, and situations that can be flexibly recombined into unique, specific ins
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Många kvinnor är oförberedda på de obehag som klimakteriet ofta för med sig. Samtidigt är svensk klimakterievård otillräcklig – och ojämnt fördelad över landet. Barnmorskan Pernilla Ny, lärare och forskare vid Lunds universitet, sprider sin evidensbaserade kunskap så långt hon förmår.
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UK trial of first non-hormonal drug for condition may lead to ‘long overdue’ innovation in relieving often debilitating pain ‘Worse than childbirth’: women with endometriosis call for better treatments Women will be given a potential new treatment for endometriosis in a groundbreaking clinical trial that doctors hope will pave the way for the first new class of drug for the condition in 40 years.
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Nature Communications, Published online: 08 March 2023; doi:10.1038/s41467-023-36911-4 During Gq protein activation, the separated Gαq-GTP forms a stable complex with the ligand-activated hM3R and PLCβ. Here the authors demonstrate that a single M3 receptor FRET probe can display the real-time conformational dynamics of innate receptor by the downstream Gq protein cycle.
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Nature Communications, Published online: 08 March 2023; doi:10.1038/s41467-023-36948-5 The role of 3D genome organization is not well understood in the transcriptional regulation of dendritic cells. Here the authors show that activation of dendritic cells in vitro induces dynamic reprogramming of the chromatin looping and enhancer activity linked to changes in gene expression and implicates a rol
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Nature Communications, Published online: 08 March 2023; doi:10.1038/s41467-023-36947-6 Developing high-entropy environmental barrier coatings is challenged by the intricacy to form stable multicomponent materials. Here the authors report the phases of high-entropy β-RE2Si2O7 could be precisely designed by monitoring the entropy descriptor and the cationic radii on rare earth sites.
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Why are ultra-pessimistic comments that are just commenter's speculation with no linked sources(reputable or otherwise) to back up up their assertions are upvoted but my comments debunking these claims and statements with links to reputable sources are almost always downvoted? Where are all the rational people? Maybe it has something to do with this subreddit being constantly brigaded by members
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Researchers have developed a new 'camera' that sees the local disorder in materials. Its key feature is a variable shutter speed: because the disordered atomic clusters are moving, when the team used a slow shutter, the dynamic disorder blurred out, but when they used a fast shutter, they could see it. The method uses neutrons to measure atomic positions with a shutter speed of around one picoseco
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A research team has shed new light on the importance of plant roots for below-ground life, particularly in the tropics. Millions of small creatures toiling in a single hectare of soil including earthworms, springtails, mites, insects, and other arthropods are crucial for decomposition and soil health. For a long time, it was believed that leaf litter is the primary resource for these animals. Howe
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Fred buys a new bulldozer in an attempt to reach his 500 oz goal, but must find a solution once the bulldozer breaks. #discoveryplus #goldrush Stream Full Episodes of Gold Rush https://www.discoveryplus.com/show/gold-rush About Gold Rush: Motivated by a depressed economy, hard-working gold miners get to work both in America and across the globe in an attempt to strike it rich. Subscribe to Discov
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House Speaker Kevin McCarthy gave Fox News access to thousands of hours of video from the events of January 6, and Tucker Carlson’s effort to rewrite history isn’t just laughably incompetent; it’s already falling flat. But first, here are three new stories from The Atlantic . Barton Gellman: A troubling sign for 2024 “ I teach international relations. I think we’re making a mistake in Ukraine.” T
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This article was featured in One Story to Read Today, a newsletter in which our editors recommend a single must-read from The Atlantic , Monday through Friday. Sign up for it here. Elizabeth often met her husband, Mitch, after work at the same restaurant in Lower Manhattan. Mitch was usually there by the time she arrived, swirling his drink and joking with a waiter. Elizabeth and Mitch had been f
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From birth, animals can use their spontaneous preferences (predispositions that are not learned) to decide which stimuli to attend and approach. Previous research has shown how infants and newborn chicks, with no previous experience with animals, are spontaneously attracted by the movement of living organisms. Now, new findings demonstrate how the movement against gravity can be particularly good
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From birth, animals can use their spontaneous preferences (predispositions that are not learned) to decide which stimuli to attend and approach. Previous research has shown how infants and newborn chicks, with no previous experience with animals, are spontaneously attracted by the movement of living organisms. Now, new findings demonstrate how the movement against gravity can be particularly good
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Researchers have created software and hardware for a 4D printer with applications in the biomedical field. In addition to 3D printing, this machine allows for controlling extra functions: programming the material's response so that shape-changing occurs under external magnetic field, or changes in its electric properties develops under mechanical deformation. This opens the door to the design of s
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Researchers have created software and hardware for a 4D printer with applications in the biomedical field. In addition to 3D printing, this machine allows for controlling extra functions: programming the material's response so that shape-changing occurs under external magnetic field, or changes in its electric properties develops under mechanical deformation. This opens the door to the design of s
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The Phlegraean volcanic fields just west of Naples, Italy, are among the top eight emitters of volcanic carbon dioxide in the world. Since 2005, the Solfatara crater — one of many circular depressions in the landscape left by a long history of eruptions –has been emitting increased volumes of gas. Today it emits 4,000-5,000 tons of carbon dioxide each day, equivalent to the emissions from burnin
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Researchers describe a new manner of detecting microbial infection that intercepts pathogen-derived signals of growth to assess the relative threat of virulent bacteria. A nuclear hormone receptor in the nematode C. elegans senses a toxic metabolite produced by the bacterial pathogen Pseudomonas aeruginosa to activate innate immunity. These data reveal an ancient strategy that informs the origins
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Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer's disease in a mouse model, according to a new study. The results illuminate one pathway for entrance of peripheral immune cells into the brain, and may provide a new target for treatment of Alzheimer's disease.
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So today at my school, we were taught about speed reading. We have been tested at speed for like 700 words/minute but the test was full in english and my native language is polish. So if i could take and understand the test at the 700 words/minute in english, could i understand more in my native lan submitted by /u/klauiel [link] [comments]
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