# News2023March16-Titles

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A new process that lets scientists chemically cut apart and stitch together nanoscopic layers of two-dimensional materials—like a tailor altering a suit—could be just the tool for designing the technology of a sustainable energy future. Researchers from Drexel University, China and Sweden, have developed a method for structurally splitting, editing and reconstituting layered materials, called MAX
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## LATEST

Steps were taken in Canada to reduce the use of Bisphenol A (BPA), a toxic chemical linked to prostate and breast cancer, commonly found in plastics, the lining of food cans, water bottles, and paper receipts.
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A cytokinin-mediated, proliferation-based mechanism is involved in the generation and maintenance of cell-type specific tissue boundaries during vascular development in Arabidopsis roots. Specifically, the HANABA-TARANU transcription factor forms a feed-forward loop to cytokinin signaling, which in turn regulates the position and frequency of cell proliferation of proto-vascular cells such that me
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A recent study makes it clear: Countries like Sweden that can link data from different areas — such as the labor market and health care — have a decisive advantage when it comes to setting targeted actions.
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Once inside the cells, the virus integrates its genome into the cellular genome and establishes persistent infections…. The role of the structure and organization of the host genome in HIV-1 infection is not well understood.
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The Fourth Industrial Revolution is driving exponential growth in data transmission, and cost-effective, ultrafast, and compact optical communication technologies are urgently needed to manage the exploding data transmission volume. Vortex beams, which exhibit a swirling shape around the axis of propagation, have the potential to increase the amount of information that can be stored at the same fr
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Very Bad Scientists are reeling from the discovery of "plastic rocks" on a remote volcanic island off of the Brazilian coast — a troubling sign, experts told Reuters , of just how deeply plastic pollution has embedded itself into Earth's geological patterns. The rocks, dubbed "plastiglomerates" — a molten mixture of sediment and debris, held together by melted plastic — have been discovered at a
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In the Crapper Virgin Orbit's financial woes have apparently deepened to the point that it has reportedly had to furlough its staff while looking for new money. In a regulatory filing , the Richard Branson-owned satellite launch outfit conceded that it is trying to "conserve capital" while it "conducts discussions with potential funding sources and explores strategic opportunities." That effort,
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A team of graduate students and researchers from the University of Miami is navigating through the northern Atlantic Ocean on an international research voyage to learn more about how the ocean is changing through time.
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'Miniature shredders' are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism.
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In organic solar cells, carbon-based polymers convert light into charges that are passed to an acceptor. Scientists have now calculated how this happens by combining molecular dynamics simulations with quantum calculations and have provided theoretical insights to interpret experimental data.
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I'm in the music tech field and came across this blog not too long ago: https://melodystudio.net/2023/02/18/ai-for-creating-music/ Seems to be a product that uses AI in songwriting. As someone who wants to go to grad school for this stuff, I know that AI is being incorporated into a lot of technology such as chord identification, but I suppose this product is a bit closer to the creative side of
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It's been said that GPT LLMs aren't sentient or intelligent, as they only react to external prompts by a human, But, considering that currently, the following technologies exist: Boston Dynamics style ambulatory robots like Spot or Atlas with onboard sensors and cameras and an advanced capacity to navigate a real life environment; GPT-4, a multimodal AI that can handle text and image prompts and
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As a scruffy gray-and-brown wolf stood in a grassy Idaho clearing, it fixed its gaze straight ahead. Another dark wolf trotted down a muddy dirt road. A third stepped over gravelly terrain, its mouth open as it panted in the sun. Motion-triggered cameras, placed by the Idaho Department of Fish and Game, snapped photos of the wild animals along trails. Later, the agency would use those photos to he
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The scientific nonprofit that tracks the white shark population in Cape Cod waters identified 55 sharks never before documented in the area during its most recent research season, but experts say that's no reason for tourists who flock to the vacation hotpsot every summer to be afraid of going in the water.
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As a scruffy gray-and-brown wolf stood in a grassy Idaho clearing, it fixed its gaze straight ahead. Another dark wolf trotted down a muddy dirt road. A third stepped over gravelly terrain, its mouth open as it panted in the sun. Motion-triggered cameras, placed by the Idaho Department of Fish and Game, snapped photos of the wild animals along trails. Later, the agency would use those photos to he
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There is currently a large dependence on coal for power generation. As coal-fired plants cause environmental and health hazards, technologies such as swirl flow and air staging have been proposed to mitigate the pollutants in their emissions. However, it is unclear how effective these technologies are in reducing the environmental costs of these plants. Now, researchers have provided insights on t
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The androgen receptor is a key transcriptional factor for the proper sex development — especially in males — and the physiological balance of all the tissues that express this receptor. The androgen receptor is involved in several pathologies and syndromes, such as the spinal and bulbar muscular atrophy or androgen insensitivity syndrome, among others, for which there is no specific treatment. R
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Excavations led by researchers from the University of Gothenburg show that the coveted metal copper and a sheltered location turned the Cypriot village of Hala Sultan Tekke into one of the most important trade hubs of the Late Bronze Age. The researchers' study published in the Journal of Archaeological Science: Reports confirms the importance of the Bronze Age city in the first period of internat
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In a study published in the journal Science China Life Sciences, Miichthys miiuy in teleost was taken as the research object to explore whether lncRNA can play a regulatory role in the process of teleost resisting susceptible pathogenic Vibrio infection. And the researchers found that the expression of lncRNA TARL was up-regulated in the spleen tissue of M. miiuy stimulated by LPS.
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Japan has declared carbon neutrality by 2050 as a government target to reduce net greenhouse gas emissions to zero by 2050. In order to substantially reduce CO2 emissions, it is important not only to control CO2 emissions through existing processes, but also to develop innovative processes to utilize CO2 as a resource for production of fuels and chemicals. The core of these efforts is technology t
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The western chimpanzees of Guinea are threatened by mining activities. Using a novel genetic approach, UZH researchers and an international team have collected information on population size and community structure of the endangered species. These data provide an important baseline to assess the impact of mining.
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In a study published in the journal Science China Life Sciences, Miichthys miiuy in teleost was taken as the research object to explore whether lncRNA can play a regulatory role in the process of teleost resisting susceptible pathogenic Vibrio infection. And the researchers found that the expression of lncRNA TARL was up-regulated in the spleen tissue of M. miiuy stimulated by LPS.
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A new forensic science study sheds light on how the bones of infants and children decay. The findings will help forensic scientists determine how long a young person's remains were at a particular location, as well as which bones are best suited for collecting DNA and other tissue samples that can help identify the deceased. "Crimes against children are truly awful, and all too common," says Ann
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Researchers have created soft robots that can seamlessly shift from walking to swimming or from crawling to rolling. Most animals can quickly transition from walking to jumping to crawling to swimming if needed without reconfiguring or making major adjustments. But most robots can't. "We were inspired by nature to develop a robot that can perform different tasks and adapt to its environment witho
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In the News story "Research gets a boost in final 2023 spending agreement" (23 December 2022, p. 1263), Science News Staff describe the large increase in the US National Institutes of Health's (NIH's) budget for the coming year. They do not mention that, despite the increase, NIH has not raised the annual cap of $500,000 on R01-equivalent budgets in more than 25 years (1). NIH should increase the 1h The Kunming-Montreal Global Biodiversity Framework (GBF) includes four goals and 23 targets to halt biodiversity loss and restore natural ecosystems by 2030 (1). The list includes goals to reduce pollution from sources such as plastics and nutrients (Target 7) but overlooks sediment—a key driver of poor water quality that threatens freshwater and marine ecosystems. To conserve aquatic environments 1h HomeScienceVol. 379, No. 6637Mitigate diseases to protect biodiversityBack To Vol. 379, No. 6637 Full accessLetter Share on Mitigate diseases to protect biodiversityAmadeus Plewnia, Philipp Böning, and Stefan Lötters [email protected]Authors Info & AffiliationsScience16 Mar 2023Vol 379, Issue 6637p. 1098DOI: 10.1126/science.aad2059 PREVIOUS ARTICLEAchieving cognitive libertyPreviousNEXT ARTICLESe… 1h America's science, technology, and innovation ecosystem is a powerful engine for progress, but it was conceived in the last century for last century's goals. Today, the nation's aspirations have never been bigger: robust health and ample opportunity for … 1h 67 Automated CEO To all the CEOs out there who might be interested in — or already are — replacing their employees with autonomous, AI-powered robots: sorry, but as The Hustle reports , the numbers are in… and it looks like it actually makes the most sense to put your job on the proverbial chopping block instead. And frankly? It makes a lot more sense than you might think. It's no secret that chie 1h A new study links an outbreak of highly pathogenic avian influenza with the deaths of more than 330 New England harbor and gray seals along the North Atlantic coast in June and July 2022. The outbreak was connected to a wave of avian influenza in birds in the region, the researchers report. HPAI is more commonly known as bird flu, and the H5N1 strain has been responsible for about 60 million poul 1h Steps were taken in Canada to reduce the use of Bisphenol A (BPA), a toxic chemical linked to prostate and breast cancer, commonly found in plastics, the lining of food cans, water bottles, and paper receipts. But in many cases, it has been replaced with similar hormone disrupting chemicals, like Bisphenol S (BPS). A new study shows that every day Canadians are exposed to BPS in the fresh foods th 1h While research has long established disparities in health outcomes among individuals living with sickle cell disease (SCD), few studies have quantified these gaps. A new study finds that the average life expectancy of publicly insured patients living with SCD is roughly 52.6 years. In contrast, the CDC reports that the average life expectancy in the United States is 73.5 years for men and 79.3 yea 1h The western chimpanzees of Guinea are threatened by mining activities. Using a novel genetic approach, researchers have collected information on population size and community structure of the endangered species. These data provide an important baseline to assess the impact of mining. 1h The future of wireless communications is set to take a giant leap with the advent of sixth-generation (6G) wireless technology. A research team has invented a groundbreaking tunable terahertz (THz) meta-device that can control the radiation direction and coverage area of THz beams. By rotating its metasurface, the device can promptly direct the 6G signal only to a designated recipient, minimizing 1h Geneticists have written new chapters in the reconstruction of pre-colonial Americas history after using DNA from the indigenous Ashaninka people from Amazonian Peru. They have discovered previously unexpected levels of genetic variation in this group and uncovered a strong hint that these people were involved in a South-to-North migration that led to the transition from an archaic to ceramic cult 1h "Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study by the University of Bonn now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism. 1h 37 Public finally able to see 3D remains of plesiosaur discovered on Lyme Regis beach 16 years ago At first when Raffle the dog began scratching at something on the beach at Lyme Regis, Tracey Barclay thought he had probably found a boring old stick or stone. But when she looked closer, Barclay realised Raffle had happened upon something much more interesting – the remains of a plesiosaur, a marine 1h Approximately 52 million square kilometers of the earth surface is made by arid zones, defined as areas where the total amount of rainfall is balanced by evaporation from the surface and natural transpiration of plants. The "right balance" between atmospheric precipitation and water evaporation is essential for soil productivity, a balance that climate change is constantly modifying, with dramatic 1h "Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required. The exact structure of these shredders differs from cell type to cell type, a study by the University of Bonn now shows. For example, cancer cells have a special variant that can supply them particularly effectively with building blocks for their energy metabolism. 1h The media have a powerful influence on how people view and treat different groups based on gender and ethnicity, as news stories shape people's stereotypes, beliefs, and ultimately behaviors in areas such as education, family, and politics. It is, therefore, essential to understand how the media, and in particular news outlets, depict different groups and whether stereotypes drive these depictions 1h Nature, Published online: 16 March 2023; doi:10.1038/d41586-023-00823-6 Universities and science employers must adopt practices to diversify their research workforce and move beyond simply hiring members of under-represented groups, finds the US National Academies of Sciences, Engineering, and Medicine. 1h Nature, Published online: 16 March 2023; doi:10.1038/d41586-023-00762-2 Technical "tour de force" allows researchers to trace the family tree of crucial brain cells. 1h Plant movement has long fascinated many researchers. Legumes are a group of plants famous for exhibiting various leaf movements, including "nyctinastic movement," in which the leaves open in the day and close at night. Similar plant movements include blue light-induced and touch-sensitive movements, such as in sensitive plants like Mimosa pudica. 2h In a new study, astronomers describe how extraterrestrial life has the potential to exist on distant exoplanets inside a special area called the 'terminator zone,' which is a ring on planets that have one side that always faces its star and one side that is always dark. 2h The sex hormone estrogen has a negative impact on heartbeat regulation, according to an experimental study. Estrogen impact seems to interact with hereditary changes causing a heart disease disturbing the heart's rhythm, while other endogenous substances may have a protecting effect. 2h For a functioning brain to develop from its embryonic beginnings, so much has to happen and go exactly right with exquisite precision, according to a just-so sequence in space and time. It's like starting with a brick that somehow replicates and differentiates into a hundred types of building materials that also replicate, while simultaneously self-assembling into a handsome skyscraper replete wit 2h 300+ Moneymaking While OpenAI is soaking up the limelight after releasing ChatGPT and its next-generation GPT-4 language model, this week , Elon Musk, who was a co-founder of the company, hasn't shied away from expressing his disdain (or horror) over its newfound direction and success. And he's not done with his groaning and moaning about the company, replying to a Twitter user who mocked its pivot to 2h 96 Enter the Multiverse With the outstanding question of " what caused the Big Bang " continuing to puzzle physicists, one of the world's most respected academics in the field has proposed a devilishly simple bargain: that we're living in a multiverse — and he'd be willing to bet his dog's life on it. In a piece for The Conversation , Cambridge cosmologist and astrophysicist Martin Rees noted that e 2h 45 Key industries — including some that the White House is backing through other policies — are lobbying to water down the first major new rules in a generation on chemicals that pose risks to humans. 2h The largest genome of any insect, seven times the size of the human genome, was recently discovered in a grasshopper. In a study published in PLOS ONE, researchers from the German Leibniz Institute for the Analysis of Biodiversity Change (LIB) and the Czech Academy of Sciences prove wrong the idea of insect genomes being comparatively small and less complex. 2h Of all the advanced technologies currently under development, one of the most fascinating and frightening is brain-computer interfaces . They're fascinating because we still have so much to learn about the human brain, yet scientists are already able to tap into certain parts of it. And they're frightening because of the sinister possibilities that come with being able to influence, read, or hija 2h Scientists revealed the discovery of a relict glacier near Mars' equator. Located in Eastern Noctis Labyrinthus at coordinates 7° 33' S, 93° 14' W, this finding is significant as it implies the presence of surface water ice on Mars in recent times, even near the equator. This discovery raises the possibility that ice may still exist at shallow depths in the area, which could have significant impli 2h Nature, Published online: 16 March 2023; doi:10.1038/s41586-023-05799-x Spatial optimizations of high-resolution data from China on crop-specific yields, harvested areas, environmental footprints and farmer incomes shows that crop switching can enhance environmental sustainability and farmer incomes, and contribute substantially towards China's agricultural sustainable development targets. 2h Nature, Published online: 16 March 2023; doi:10.1038/d41586-023-00816-5 Researchers are excited about the AI — but frustrated about the secrecy over its underlying engineering. 2h We all experience it: that desire to do something wrong just for the sake of it. Whether it's walking on manicured grass or sticking your finger in a friend's ice cream, psychologist Paul Bloom invites us to see the clever, creative and beautiful side of these minor impulses to do bad. He dives into the psychology behind this all-too-human condition — and proposes that it helps make our world a l 2h Visenter och älgar har fört en tynande tillvaro i Centraleuropa men de skulle kunna göra comeback, visar en studie. Men ett myller av motorvägar och stängsel kan ställa till bekymmer för de vandrande bjässarna – och är de välkomna tillbaka? Inlägget dök först upp på forskning.se . 3h 100+ Waitlist Begone The floodgates have officially opened. According to Windows Central , Microsoft's chatty, AI-powered search feature — you know, the one that tried to break up a New York Times writer's marriage , named its enemies , and threatened users that provoked it, among a few other things — is now open for general use. The feature was formerly available to just a limited number of users, wh 3h Producing meat pollutes and requires a lot of space and resources (water, grains…). To protect the planet, we must therefore find new sources of protein. One of the solutions is to replace, at least partially, meat by insects. 3h Shallow lakes can take on two alternative stable states, according to a theory on ecological equilibrium in the study of inland waters (limnology). This paradigm has now been called into question by a study conducted by the Helmholtz Centre for Environmental Research (UFZ) and Aarhus University (Denmark) and published in the journal Nature Communications. 3h Using an RNA sensor, MIT engineers have designed a new way to trigger cells to turn on a synthetic gene. Their approach could make it possible to create targeted therapies for cancer and other diseases, by ensuring that synthetic genes are activated only in specific cells. 3h 95 Even as the riot of January 6, 2021, was unfolding, and Americans could see a mob of Trump supporters storming the Capitol in an effort to overturn the 2020 presidential election, Trumpists were telling people not to believe their own eyes. They said the rioters were harmless tourists , they claimed the riot itself was an inside job by the FBI , they insisted that antifa was responsible, and they 3h Nature, Published online: 16 March 2023; doi:10.1038/d41586-023-00821-8 Bad mentors can go absent, sap your energy or embroil you in their paranoia. Here are five tips for tackling a toxic relationship. 3h The androgen receptor is a key transcriptional factor for the proper sex development—especially in males—and the physiological balance of all the tissues that express this receptor. The androgen receptor is involved in several pathologies and syndromes, such as the spinal and bulbar muscular atrophy or androgen insensitivity syndrome, among others, for which there is no specific treatment. 3h A new study is providing an unprecedented examination of oxygen loss on coral reefs around the globe under ocean warming. Led by researchers at UC San Diego's Scripps Institution of Oceanography and a large team of national and international colleagues, the study captures the current state of hypoxia—or low oxygen levels—at 32 different sites, and reveals that hypoxia is already pervasive on many 3h A new study is providing an unprecedented examination of oxygen loss on coral reefs around the globe under ocean warming. Led by researchers at UC San Diego's Scripps Institution of Oceanography and a large team of national and international colleagues, the study captures the current state of hypoxia—or low oxygen levels—at 32 different sites, and reveals that hypoxia is already pervasive on many 3h The androgen receptor is a key transcriptional factor for the proper sex development—especially in males—and the physiological balance of all the tissues that express this receptor. The androgen receptor is involved in several pathologies and syndromes, such as the spinal and bulbar muscular atrophy or androgen insensitivity syndrome, among others, for which there is no specific treatment. 3h After almost a decade of effort, scientists at RIKEN have determined the structure of a key transporter protein that helps plants gather iron from soil. This finding could guide the development of new high-potency fertilizers that will help plants extract iron from iron-deficient soils. 3h Air pollution is a major public health problem: The World Health Organization has estimated that it leads to over 4 million premature deaths worldwide annually. Still, it is not always extensively measured. But now an MIT research team is rolling out an open-source version of a low-cost, mobile pollution detector that could enable people to track air quality more widely. 3h 200+ What movie do these emojis describe? That prompt was one of 204 tasks chosen last year to test the ability of various large language models (LLMs) — the computational engines behind AI chatbots such as ChatGPT. The simplest LLMs produced surreal responses. "The movie is a movie about a man who is a man who is a man," one began. Medium-complexity models came closer, guessing The Emoji Movie. Sourc 4h 35 Stiff Competition SpaceX's broadband-beaming Starlink satellites may soon be facing some stiff competition, because Amazon has been working on a satellite network of its own called Project Kuiper. This week, the company revealed its newly designed terminals that can connect customers to the internet from essentially anywhere in the world. But there's one huge catch: while SpaceX has sent over 3,5 4h Nature Communications, Published online: 16 March 2023; doi:10.1038/s41467-023-36972-5 While reflective pavement has been proposed and applied in pilot projects, its actual cooling performance remains unclear. Here, authors assessed the cooling potential of reflective pavement in Phoenix, AZ, using multiple heat metrics, reflectivity measures, and literature to provide a set of implementation gui 4h Whiplash vs Monsoon full fight! #discoveryplus #battlebots Stream Full Episodes of Battlebots https://www.discoveryplus.com/show/battlebots About Battlebots: Next-generation robots from all over the globe trade blows to reign supreme. The series highlights the design and build of each robot, bot-builder backstories and the pursuit of the BattleBots championship. Subscribe to Discovery: https://ww 4h Scientists at the Department of Energy's Oak Ridge National Laboratory have confirmed that bacteria-killing viruses called bacteriophages deploy a sneaky tactic when targeting their hosts: They use a standard genetic code when invading bacteria, then switch to an alternate code at later stages of infection. 4h Engineers have figured out why some particles, like microplastics, get concentrated and aerosolized by bursting bubbles, while others don't. When a bubble pops, it can concentrate and aerosolize any particles stuck on it. That's a major concern when the particles it carries are potentially hazardous: bubbles caught in a crashing wave can send vaporized microplastics into the air where they might 4h Last week, recuperating from some dental work, I spent a lot of time as a potato. No, not a couch potato but a video-game potato. With a machine gun. Actually, six machine guns, to be precise. What I'm saying is that, like more than 1 million other people, I was playing Brotato , one of the year's most unlikely video-game hits. In terms of basic gameplay, Brotato is exactly what it sounds like: a 4h A new forensic science study sheds light on how the bones of infants and juveniles decay. The findings will help forensic scientists determine how long a young person's remains were at a particular location, as well as which bones are best suited for collecting DNA and other tissue samples that can help identify the deceased. 4h We add some of the CMIP6 models to the updateable MSU comparisons. After my annual update , I was pointed to some MSU-related diagnostics for many of the CMIP6 models (24 of them at least) from Po-Chedley et al. (2022) courtesy of Ben Santer . These are slightly different to what we have shown for CMIP5 in that the diagnostic is the tropical corrected-TMT (following Fu et al., 2004 ) which is a b 4h Nature, Published online: 15 March 2023; doi:10.1038/d41586-023-00814-7 An entomologist's love letter to the humble larval life stage of dazzling butterflies and moths. Plus, how heartbeats shape our perception of time and what the Silicon Valley Bank collapse means for science. 4h It's not like we needed one more hack to understand how bad of a data-storage solution centralized servers are. Every year we see way more than 20 headlines about hackers gaining access to users' sensitive data and information. So why do these tech companies still store data the same exact way? Why do they still keep every email you send and receive if they're locking up our data in a wooden box 4h Cells harvested from your own muscles could one day improve or even save your life if you are suffering from muscle loss after disease or an injury. The implantation of muscle cells offers an incredibly promising treatment for conditions such as muscular dystrophy, heart failure and incontinence. 4h The Ashaninka are the most numerous Indigenous people living in the rainforests of Peru and Brazil where they inhabit a crucial area between the Andes and sources of the Amazon River. And yet, despite the size of the population and their importance in the past and present, their genetic history has remained understudied. 4h If you had to choose between trusting your eyes, your ears, or your common sense, which would you choose? I made this choice not long ago when I was scrolling through instagram and came across a video that made me doubt my senses. I rewatched it 3 times thinking, "How is this even real?" It […] 5h New research establishes a link between Western diets high in fat and sugar and the development of non-alcoholic fatty liver disease, the leading cause of chronic liver disease. The research has identified the western diet-induced microbial and metabolic contributors to liver disease, advancing understanding of the gut-liver axis, and, in turn, the development of dietary and microbial interventio 5h 500+ Bad Precedent OpenAI released its hotly-anticipated GPT-4 on Tuesday, providing a 98-page " technical report " on the latest iteration of its large language model (LLM). But despite the lengthy documentation and the company's not-for-profit roots, OpenAI has revealed extremely little information about how its latest AI actually works — which has experts worried, Venture Beat reports . OpenAI, how 5h Nature Communications, Published online: 16 March 2023; doi:10.1038/s41467-023-37159-8 Many patients with hypopharyngeal carcinoma (HPC) do not respond to first-line combination therapy. Here, the authors analyse the tumour and the tumour microenvironment of HPC patients treated with combination therapy using single-cell RNA-seq, and train a classifier to distinguish responders based on cell type 5h Nature Communications, Published online: 16 March 2023; doi:10.1038/s41467-023-37197-2 Previous demonstrations of quantum interference in solids have mainly been limited to intra-layer transport within single conductors. Zhu et al. report a new type of inter-layer quantum interference in graphene-based double-layer devices, due to interference between carrier diffusion paths across the constituen 5h The year is 1959. Speleologists descend a 17-meter shaft to explore the depths of Mairs Cave in the southern Flinders Ranges. Some 55 meters into the main chamber, they find fossils scattered throughout a boulder pile. Among these fossils are a claw and part of a wing bone that appear to have come from a large eagle. 5h A team of oceanographers at the University of Bologna and The Inter-Institute Center for Research on Marine Biodiversity has found, via a seven-year study, that artificial reefs may provide a unique opportunity to study new ways to protect natural coral reefs. Their paper is available in the open-access journal PLoS ONE. 5h In order to deliver cancer therapeutics to tumor cells, the cells' membranes must be overcome. A team of researchers have discovered a simple way to achieve this using lipid nanoparticles containing the reagent EDTA (ethylenediaminetetraacetic acid). As the team report in the journal Angewandte Chemie, an unusual mechanism of action of EDTA is responsible for this useful effect. 5h 91 A team of chemists at Purdue University, working with a pair of colleagues from the University of Kentucky, has developed a way to make PBDF, a type of transparent conducting material, at an easily synthesized scale. In their paper published in Journal of the American Chemical Society, the group describes their new technique and possible applications. 5h The risk of death rises among older adults with Alzheimer's or other dementia in the months following exposure to a hurricane, a new study shows. Previous studies of hurricanes have shown general increases in mortality but little has been known about how mortality following hurricane exposure may differ among older adults living with dementia. Their increased risk could be due to disruption of no 6h Modern gender norms and biases in Europe have deep historical roots dating back to the Middle Ages and beyond, research finds. The findings—published in the Proceedings of the National Academy of Sciences —highlight why gender norms have remained stubbornly persistent in many parts of the world despite significant strides made by the international women's rights movement over the last 100-150 yea 6h Scientific Reports, Published online: 16 March 2023; doi:10.1038/s41598-023-31512-z Perovskite solar cells must overcome the long-term stability problem in order to be put into practical use. Materials science, through the development of synthetic chemistry, materials characterization and device engineering can contribute to improvements in stability and scalability towards enabling large scale p 6h 42 To understand how cells behave, researchers also need to understand the molecules that make them work. "If someone wants to know how the kidney functions, they have to know what's going on inside the kidney cells," says Yang Liu, Ph.D., assistant professor of pathology. "This is defined by the protein activity." 6h Nature Communications, Published online: 16 March 2023; doi:10.1038/s41467-023-37170-z The upstream metabolism of tryptophan has been described as a metabolic node in glioblastoma. Here the authors show that the downstream metabolism of tryptophan, resulting in the accumulation of quinolinate in glioblastoma, contributes to pro-tumorigenic immune suppressive activation of macrophages. 6h Nature Communications, Published online: 16 March 2023; doi:10.1038/s41467-023-37003-z Antimicrobial peptides (AMPs) are next-generation antibiotics that can be used to combat drugresistant pathogens. Here, the authors report efficient production of bioactive amidated AMPs by transient expression in Nicotiana benthamiana line expressing the mammalian enzyme peptidylglycine α-amidating mono-oxygen 6h Nature Communications, Published online: 16 March 2023; doi:10.1038/s41467-023-37127-2 Whether a species declines under the current biodiversity crisis could partly depend on its range size. Here, the authors use replicated metacommunity data to identify global patterns in the relationship between species' range size and changes in occupancy through time. 6h In a society that is chronically online, the term "fatphobic" is often used to describe certain public figures, pieces of media and industries. One example is Taylor Swift's video for "Anti-Hero." Another is a movie titled "The Whale," which opened late last fall to wide critical acclaim and details the struggles of an obese man played by Brendan Fraser, who was recognized with the Oscar for Best 6h A detailed "body scan" of Malaspina Glacier, one of Alaska's most iconic glaciers, revealed that its bulk lies below sea level and is undercut by channels that may allow ocean water to gain access, should its coastal barrier erode. This makes the glacier more vulnerable to seawater intrusion than previously thought and may cause it to retreat faster than predicted. 6h This is today's edition of The Download , our weekday newsletter that provides a daily dose of what's going on in the world of technology. These aircraft could change how we fly Some companies think it's time the aviation industry got a makeover, and many are betting it'll come in the form of eVTOLs: electric vertical take-off and landing vehicles. There are hundreds of companies working to bring 6h Nature Communications, Published online: 16 March 2023; doi:10.1038/s41467-023-36953-8 The authors combined optical traps and frequency combs to create new acoustic technology – a mechanical frequency comb. The generation of this comb does not require any precision control, making it uniquely positioned for sensing, metrology, and quantum technology. 7h Good spacesuits are deceptively difficult to design, even with today's technology. NASA is planning to return to the moon in 2025 (if all goes well) but the spacesuit the astronauts will wear is one piece to the puzzle they have not completed yet (the other being the lunar lander). In fact, NASA spent$420 million on spacesuit development but was unhappy with the results. They therefore contracte
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Cancer patients report heightened infection concerns, increased feelings of fear, and disrupted care during COVID-19. The findings are an update to a previous analysis of the effects of living with cancer during the pandemic. The new study appears in the journal Clinical Cancer Research . "The pandemic elicited a lot of uncertainty and dread and made people feel vulnerable," says Mustafa Khasraw,
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There is a reason you have not come across a unicorn fossil in a museum exhibit, let alone seen one in a zoo or heard an iconic grandfatherly voice detail their daily trepidations in a BBC documentary. The reason being—spoiler alert—we have not yet managed to capture one. However, it hasn't been for lack of trying. as documented by a research article in the Cambridge Archaeological Journal, Europe
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Robert Garcia, a 45-year-old former Long Beach, California, mayor and newly elected Democratic U.S. representative, is hardly the first openly gay member of Congress, but there's something unique and irreverent in how he has approached his first few months on the job. He's publicly celebrated drag culture, casually criticized Republican colleagues on Twitter, and paid tribute to Beyoncé on the Ho
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M ost Americans who have heard of the John Birch Society associate it with the political fringe—and rightly so. Founded in 1958 by a small band of anti–New Deal businessmen, the society rejected virtually the entire post–World War II, U.S.-led international order. Birchers urged the United States to get out of the United Nations, denounced the foreign-policy establishment as a communist cabal, an
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You should be mad about the chaotic and swift collapse of Silicon Valley Bank. If you are a customer of Silicon Valley Bank, you should be furious with its executives for their incompetent risk management and poor communications strategy. If you work in start-ups or the technology sector, you should be angry at the venture capitalists who spurred a bank run at SVB only to turn around and beg for
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A nti-immigration activists, a Los Angeles oil and natural-gas company, historic preservationists, and bird enthusiasts make for unlikely bedfellows. But in recent years, they've all embraced the power of decades-old environmental laws—not to protect the environment but to defend the status quo. Stick with me here. Signed into law in 1970, the National Environmental Policy Act and its state and l
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Foregen is a non-profit organization that aims to develop innovative non-surgical methods for restoring the foreskin. Male circumcision, which involves the removal of the foreskin, is a common practice in many cultures and religions around the world. However, it can lead to physical, sexual, and psychological complications, including decreased sensitivity, scarring, and trauma. Foregen's goal is
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what are some skills that WONT be replaced by AI? better start preparing. submitted by /u/Mysterious-Grand-787 [link] [comments]
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" How to Build a Life " is a column by Arthur Brooks, tackling questions of meaning and happiness. Click here to listen to his podcast series on all things happiness, How to Build a Happy Life . How are your New Year's resolutions going? Perhaps that's a sore subject. Resolutions usually fail , sometimes even in the first few months of the year (one study found that half dissolved after three mon
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An international panel of scientists have identified 100 of the most important questions facing plant science. The international initiative has identified key research priorities and highlights the importance of diversity, collaboration, and funding for plant research to tackle climate change, the biodiversity crisis and sustainable food production.
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Nature Communications, Published online: 16 March 2023; doi:10.1038/s41467-023-36724-5 The Tetrahymena ribozyme changes conformations to perform its self-splicing function. Here, the authors capture six structural snapshots of ribozyme during the second step of self-splicing from a single specimen, revealing the structural basis of how it promotes and coordinates self-splicing reactions.
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An international panel of scientists have identified 100 of the most important questions facing plant science. The international initiative has identified key research priorities and highlights the importance of diversity, collaboration, and funding for plant research to tackle climate change, the biodiversity crisis and sustainable food production.
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This article is from The Spark, MIT Technology Review's weekly climate newsletter. To receive it in your inbox every Wednesday, sign up here. This week I fell down a bit of a rabbit hole and developed a mild obsession with flying cars—or the version of them that's hot right now in Silicon Valley, at least. Some companies think it's time the aviation industry got a makeover, and many are betting i
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Rajivir Dahiya In June of 2020, officials from the Veterans Affairs Medical Center of San Francisco and the University of California, San Francisco, sent a letter to the journal Oncogene with the findings of an investigation of scientific misconduct: A paper the journal had published in 2007 contained "falsified data," and the officials recommended the journal "assess this paper for retraction."
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Satellite launch company hunts for funding lifeline following failed attempt from UK soil Virgin Orbit has paused its operations and furloughed its workforce as it hunts for a funding lifeline. The satellite launch company, based in California, will put all work on hold for at least a week with just a skeleton team remaining at work. Continue reading…
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Come mating season, fishes off the California coast sing songs of love in the evenings and before sunrise. They vocalize not so much as lone crooners but in choruses, in some cases loud enough to be heard from land. It's a technique of romance shared by frogs, insects, whales, and other animals when the time is right.
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Open access notables Jeongmin Yun et al. tag increasing acidifcation as a root cause of changes in behavior of CO2 fluxes below the equator, in Enhanced seasonal amplitude of atmospheric CO2 by the changing Southern Ocean carbon sink . "The enhanced seasonal amplitude of atmospheric CO2 has been viewed so far primarily as a Northern Hemisphere phenomenon. Yet, analyses of atmospheric CO2 records
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Will it ever be possible to dramatically alter and improve the bone structure and facial features of really ugly people to the extent that they could become average or attractive? Could people change their faces to look like models or celebrities? Could faces be changed without surgery like invasive nanobots or gene therapies? Could AI be used to analyze facial flaws and even perform cosmetic sur
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I am not well versed in robotics so I was wondering for those of you who are knowledgable, does the advancement of robotics technology used in manufacturing or construction seem to be increasing (at the rate where we could see industry shifting advances within the next decade), or are we still a long ways away from seeing boston dynamics type robots being used in construction for example? submitt
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By "best", I mean that even though some journals provide authors the option of publishing under Open Access, they charge a lot of fees (more than $1000 or even$2000). And I doubt that the reviewers get anything more than 15-20% of the fees paid by the authors, with the rest of it going into the pockets of the publishing company itself. So, I'm looking for journals that (i) either charge minimal
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Ian Sample speaks to Guardian science correspondent Hannah Devlin about the latest developments and debates about gene editing to emerge from a summit at the Francis Crick Institute in London. The summit heard from the first person with sickle cell disease to be treated with a technique known as Crispr. He also hears from Prof Claire Booth about ensuring these cutting edge treatments are made avai
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Ian Sample speaks to Guardian science correspondent Hannah Devlin about the latest developments and debates about gene editing to emerge from a summit at the Francis Crick Institute in London. The summit heard from the first person with sickle cell disease to be treated with a technique known as Crispr . He also hears from Prof Claire Booth about ensuring these cutting edge treatments are made av
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In 1935, Erd\H{o}s proved the sums $f_k=\sum_n 1/(n\log n)$, over integers $n$ with exactly $k$ prime factors, are uniformly bounded, and in 1993 Zhang proved $f_k$ is maximized by the prime sum $f_1=\sum_p 1/(p\log p)$. According to a 2013 conjecture of Banks and Martin, the sums $f_k$ are predicted to decrease monotonically in $k$. In this article, we show the sums restricted to odd integers are
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Outfits for planned lunar expedition more streamlined and flexible than Apollo suits, and a better fit for women The big, puffy white moonsuits worn by Neil Armstrong and his fellow Apollo astronauts a half-century ago are out of fashion. Lunar haute couture now calls for something more form-fitting and comfortable for men and women. Nasa on Wednesday unveiled the first prototype for a newly desi
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Some projections show that widespread adoption of electric vehicles might require costly new power plants to meet peak loads in the evening. A new study shows that placing EV charging stations strategic ways and setting up systems to initiate charging at delayed times could lessen or eliminate the need for new power plants.
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Researchers shed light on the neural stem and progenitor cell (NSPC) microenvironment during development. Neurosphere formation from embryonic mouse forebrain NSPCs was significantly increased under low oxygen conditions, and VEGF-A was identified as a factor released by NSPCs to contribute to this effect. This study demonstrates that NSPCs appear to maintain their own niche and population under l
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Proteins are the heavy-lifters of biochemistry. These beefy molecules act as building blocks, receptors, processors, couriers and catalysts. Naturally, scientists have devoted a lot of research to understanding and manipulating proteins.
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Looking back in history, we've made predictions in the face of technology trends and high optimism before, only to be disappointed and wrong many times. With the rapid pace and progress of AI, will we see AGI and Singularity event in our life time? I did write an in-depth article on this topic and do believe we will see it sooner than most expect and agree with Kurzweil's predictions with his sup
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This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here. Yesterday, not four months after unveiling the text-generating AI ChatGPT, OpenAI launched its latest marvel of machine learning: GPT-4. The new large-language model (LLM) aces select standardized test
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This is an edition of Up for Debate, a newsletter by Conor Friedersdorf. On Wednesdays, he rounds up timely conversations and solicits reader responses to one thought-provoking question. Later, he publishes some thoughtful replies. Sign up for the newsletter here. Question of the Week I was overwhelmed by your responses to last week's question on cars! So for now, I'm going to hold off on a new q
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It's finally happened — scientists have brought about the birth of baby mice using stem cells from two males. As Agence France-Presse reports , a team of Japanese scientists used tail skin cells from two male mice to father a litter of seven babies. The research builds on the team's prior studies in which they were able to make eggs out of skin cells from a single female mouse and subsequently br
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Bad things happen to a human body in zero gravity. Just look at what happens to astronauts who spend time in orbit: Bones disintegrate. Muscles weaken. So does immunity. "When you go up into space," says Saïd Mekari, who studies exercise physiology at the University of Sherbrooke, in Canada, "it's an accelerated model of aging." Earthbound experiments mimicking weightlessness have revealed simila
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Just when you think she can't outdo herself, she does. Oscar-winning actress, Goop founder, and candlemaker Gwyneth Paltrow is back on the oversharing circuit once again, sending the internet ablaze this morning after admitting on a podcast — a Dear Media show called " The Art of Being Well ," of course — that the "weirdest" thing she's ever done for the sake of "wellness" is… rectal ozone ther
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Potential talents of children with characteristics of giftedness are not always seen in mainstream education. Children's drawings, however, can play a role in early detection of their needs and talents, argues psychologist Sven Mathijssen in his dissertation titled "Back to the drawing board: Potential indicators of giftedness in human figure drawings," which he defends on March 22, 2023.
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Under certain conditions, the fusion devices known as tokamaks can suffer a sudden loss of energy to the vessel walls. Researchers call this energy loss process a disruption. One cause is a magnetohydrodynamic (i.e., conducting plasma in a magnetic field) instability, or mode, coupling to the vacuum vessel.
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The long-term effects on forests of more extreme climate events, plus other drivers of forest change, are highly uncertain. A new study of the tropical forests across Puerto Rico and the U.S. Virgin Islands (USVI), spanning 19 years, found that after Hurricane Maria in 2017, the total biomass of a fast-growing non-native species, the African tulip Tree (Spathodea campanulata), may again be overtak
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The long-term effects on forests of more extreme climate events, plus other drivers of forest change, are highly uncertain. A new study of the tropical forests across Puerto Rico and the U.S. Virgin Islands (USVI), spanning 19 years, found that after Hurricane Maria in 2017, the total biomass of a fast-growing non-native species, the African tulip Tree (Spathodea campanulata), may again be overtak
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from my time lurking in here is all groom and doom that AI and robots will make out obsolete in every single way imaginable. human phaseout is almost unpreventable in long run is really that bleak? is 3.5 billion years of evolution amounts so little? there has be something we can do, or are better than even a strong AI right? I hope at least there some value for humans. I can only come up with fe
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The highly contagious canine distemper virus is dangerous to dogs and wild life animals. It is also closely related to the equally highly contagious measles virus. Researchers at the University of Bern and the Zurich University of Applied Sciences have now for the first time determined the structure of the canine distemper virus "docking protein" and depicted it at molecular level. This lays the g
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Using solar energy to convert CO2 into synthetic fuels is currently one of the most promising technologies to achieve carbon neutrality with the embedment of sustainable energy into our modern economy. However, the efficiency of photocatalytic CO2 conversion is greatly limited due to the high thermodynamic stability of CO2 molecules and their multiple-electron-reduction process.
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Having examined the impact of various factors on cryptocurrency returns, HSE economists found that fluctuations in cryptocurrency prices can be better explained by equity market risks than by factors specific to the crypto market, suggesting greater linkages between cryptocurrency and equity markets than previously believed. The study is published in a special issue of International Finance Review
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The highly contagious canine distemper virus is dangerous to dogs and wild life animals. It is also closely related to the equally highly contagious measles virus. Researchers at the University of Bern and the Zurich University of Applied Sciences have now for the first time determined the structure of the canine distemper virus "docking protein" and depicted it at molecular level. This lays the g
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The rise in social entrepreneurship over the last 20 years denotes a major global economic and political movement. Social entrepreneurs generate substantial positive outcomes, but while they make up 2% or more of GDP in countries like Canada, Australia and the UK, many other societies have a shortage of them. A recent study from a special issue of the Strategic Entrepreneurship Journal (SEJ) sugge
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A new study published in Nature reports that a technology known as spatial omics can be used to map simultaneously how genes are switched on and off and how they are expressed in different areas of tissues and organs. This improved technology, developed by researchers at Yale University and Karolinska Institutet, could shed light on the development of tissues, as well as on certain diseases and ho
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Imagine a universe with extremely strong gravity. Stars would be able to form from very little material. They would be smaller than in our universe and live for a much shorter amount of time. But could life evolve there? It took human life billions of years to evolve on Earth under the pleasantly warm rays from the Sun after all.
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A new study published in Nature reports that a technology known as spatial omics can be used to map simultaneously how genes are switched on and off and how they are expressed in different areas of tissues and organs. This improved technology, developed by researchers at Yale University and Karolinska Institutet, could shed light on the development of tissues, as well as on certain diseases and ho
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So i recently launched a new site (my first ever site) that displays stories written by AI and updates them daily. There is also a merch store and users are able to order custom framed chronicles. Please let me know your opinions on the site / where i can improve submitted by /u/Sufficient-Yellow461 [link] [comments]
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For my Bachelor of Cognitive Science it is mandatory to have a semster abroad where we can go to an university or do an internship. I would love to get some practical experience in an internship, but I'm not quite sure where I can apply. Do you have ideas, companies, projects, own experiences… that could help me out? Thanks in advance 🙂 submitted by /u/Hiama7 [link] [comments]
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Venus appears to have volcanic activity, according to a new research paper that offers strong evidence to answer the lingering question about whether Earth's sister planet currently has eruptions and lava flows. Venus, although similar to Earth in size and mass, differs markedly in that it does not have plate tectonics. The boundaries of Earth's moving surface plates are the primary locations of v
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It may be better to let a mild fever run its course instead of automatically reaching for medication, new University of Alberta research suggests. Researchers found that untreated moderate fever helped fish clear their bodies of infection rapidly, controlled inflammation and repaired damaged tissue. Moderate fever is self-resolving, meaning that the body can both induce it and shut it down natural
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In a step forward for genetic engineering and synthetic biology, researchers have modified a strain of Escherichia coli bacteria to be immune to natural viral infections while also minimizing the potential for the bacteria or their modified genes to escape into the wild.
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Picture released of star in Sagitta constellation on the cusp of going supernova James Webb telescope gives a stunning look at galaxies far, far away The James Webb space telescope has captured the rare and fleeting phase of a star on the cusp of death. The observation was among the first made by the telescope following its launch in late 2021, but the picture was not released until this week. We
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Abstract Patterning is attractive for nanofabrication, electron devices, and bioengineering. However, achieving the molecular-scale patterns to meet the demands of these fields is challenging. Here, we propose a bubble-template molecular printing concept by introducing the ultrathin liquid film of bubble walls to confine the self-assembly of molecules and achieve ultrahigh-precision assembly up t
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Abstract Symbiotic cnidarians such as corals and anemones form highly productive and biodiverse coral reef ecosystems in nutrient-poor ocean environments, a phenomenon known as Darwin's paradox. Resolving this paradox requires elucidating the molecular bases of efficient nutrient distribution and recycling in the cnidarian-dinoflagellate symbiosis. Using the sea anemone Aiptasia, we show that dur
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Abstract Spin and valley indices represent the key quantum labels of quasi-particles in a wide class of two-dimensional materials and form the foundational elements of the fields of spintronics and valleytronics. Control over these degrees of freedom, therefore, remains the central challenge in these fields. Here, we show that femtosecond laser light combining optical frequency circularly polariz
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Abstract Discovering the secrets of diseases from tear extracellular vesicles (EVs) is well-recognized and appreciated. However, a precise understanding of the interaction network between EV populations and their biogenesis from our body requires more in-depth and systematic analysis. Here, we report the biological profiles of different-size tear EV subsets from healthy individuals and the origin
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Abstract Developing artificial symbionts beyond natural synthesis limitations would bring revolutionary contributions to agriculture, medicine, environment, etc. Here, we initiated a solar-driven multi-organism symbiont, which was assembled by the CO 2 fixation module of Synechocystis sp., N 2 fixation module of Rhodopseudomonas palustris , biofunctional polypeptides synthesis module of Bacillus
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Abstract ESCRT-III family proteins form composite polymers that deform and cut membrane tubes in the context of a wide range of cell biological processes across the tree of life. In reconstituted systems, sequential changes in the composition of ESCRT-III polymers induced by the AAA–adenosine triphosphatase Vps4 have been shown to remodel membranes. However, it is not known how composite ESCRT-II
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Abstract The aldol reaction is among the most powerful and strategically important carbon–carbon bond–forming transformations in organic chemistry. The importance of the aldol reaction in constructing chiral building blocks for complex small-molecule synthesis has spurred continuous efforts toward the development of direct catalytic variants. The realization of a general catalytic aldol reaction
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Abstract Motilin is an endogenous peptide hormone almost exclusively expressed in the human gastrointestinal (GI) tract. It activates the motilin receptor (MTLR), a class A G protein–coupled receptor (GPCR), and stimulates GI motility. To our knowledge, MTLR is the first GPCR reported to be activated by macrolide antibiotics, such as erythromycin. It has attracted extensive attention as a potenti
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Abstract Mutations of the androgen receptor (AR) associated with prostate cancer and androgen insensitivity syndrome may profoundly influence its structure, protein interaction network, and binding to chromatin, resulting in altered transcription signatures and drug responses. Current structural information fails to explain the effect of pathological mutations on AR structure–function relationshi
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Abstract In the past two decades, substantial advances have been made on the asymmetric alkyne functionalization by the activation of inert alkynes. However, these asymmetric transformations have so far been mostly limited to transition metal catalysis, and chiral Brønsted acid–catalyzed examples are rarely explored. Here, we report a chiral Brønsted acid–catalyzed dearomatization reaction of phe
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Abstract We use direct numerical simulations to study homogeneous and isotropic turbulent flows of dilute polymer solutions at high Reynolds and Deborah numbers. We find that for small wave numbers k , the kinetic energy spectrum shows Kolmogorov-like behavior that crosses over at a larger k to a novel, elastic scaling regime, E ( k ) ∼ k −ξ , with ξ ≈ 2.3. We study the contribution of the polyme
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Abstract Outer membrane vesicles (OMVs) play vital roles in bacterial communication both intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota–derived OMVs in the intestine remain poorly understood. Here, we report that OMVs released from Akkermansia muciniphila are able to (i) restore disturbed balance of the gut microbiota by selectively promoting the prol
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Abstract Immune checkpoint inhibitors (ICIs) enhance anticancer immunity by releasing repressive signals into tumor microenvironments (TMEs). To be effective, ICIs require preexisting immunologically "hot" niches for tumor antigen presentation and lymphocyte recruitment. How the mutational landscape of cancer cells shapes these immunological niches remains poorly defined. We found in human and mu
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Abstract The potato cyst nematode (PCN) causes extensive crop losses worldwide. Because the hatching of PCN requires host-derived molecules known as hatching factors (HFs), regulating HF production in host plants may help to control this harmful pest. Solanoeclepin A (SEA), isolated from potato, is the most active HF for PCN; however, its biosynthesis is completely unknown. We discovered a HF cal
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Abstract Artificial dry adhesives have exhibited great potential in the field of robotics. However, there is still a wide gap between bioinspired adhesives and living tissues, especially regarding the surface adaptability and switching ability of attachment/detachment. Here, we propose a sensing-triggered stiffness-tunable smart adhesive material, combining the functions of muscle tissues and sen
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Abstract Proteins destined for the secretory compartment of the cell are cotranslationally translocated into the endoplasmic reticulum. The majority of these proteins are N-glycosylated, a co- and posttranslational modification that ensures proper protein folding, stability, solubility, and cellular localization. Here, we show that the Please refer to original article for complete formulae. subun
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Abstract Estradiol (17 Please refer to original article for complete formulae. -E2) is implicated in higher arrhythmia risk of women with congenital or acquired long-QT syndrome (LQTS) compared to men. However, the underlying mechanisms remain poorly understood, and little is known about the impact of LQTS-associated mutations. We show that 17 -E2 inhibits the human cardiac Kv7.1/KCNE1 channel ex
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Abstract The cytoskeletal proteins tubulin and actin are the obligate substrates of TCP-1 ring complex/Chaperonin containing TCP-1 (TRiC/CCT), and their folding involves co-chaperone. Through cryo–electron microscopy analysis, we present a more complete picture of TRiC-assisted tubulin/actin folding along TRiC adenosine triphosphatase cycle, under the coordination of co-chaperone plp2. In the ope
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Abstract Van der Waals (vdW) stacking of two-dimensional (2D) materials to create artificial structures has enabled remarkable discoveries and novel properties in fundamental physics. Here, we report that vdW stacking of centrosymmetric 2D materials, e.g., bilayer MoS 2 (2LM) and monolayer graphene (1LG), could support remarkable second-harmonic generation (SHG). The required centrosymmetry break
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Abstract Sub-angstrom resolution imaging of porous materials like zeolites is important to reveal their structure-property relationships involved in ion exchange, molecule adsorption and separation, and catalysis. Using multislice electron ptychography, we successfully measured the atomic structure of zeolite at sub-angstrom lateral resolution for 100-nanometer-thick samples. Both lateral and dep
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Abstract Reactivation of the latent HIV-1 reservoir is a first step toward triggering reservoir decay. Here, we investigated the impact of the BAF complex inhibitor pyrimethamine on the reservoir of people living with HIV-1 (PLWH). Twenty-eight PLWH on suppressive antiretroviral therapy were randomized (1:1:1:1 ratio) to receive pyrimethamine, valproic acid, both, or no intervention for 14 days.
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Abstract Thermal fluctuations often impose both fundamental and practical measurement limits on high-performance sensors, motivating the development of techniques that bypass the limitations imposed by thermal noise outside cryogenic environments. Here, we theoretically propose and experimentally demonstrate a measurement method that reduces the effective transducer temperature and improves the m
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Hush Hush Meta-formerly-Facebook just laid off another 10,000 workers. But as Insider points out , CEO Mark Zuckerburg's latest announcement-slash-apology letter to his loyal Metamates, posted to Facebook on Tuesday, was missing one \$15 billion-plus phrase: the metaverse. The case of the missing metaverse wouldn't be such a big deal if Zuckerberg hadn't literally rebranded the entire company to f
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Rent the Runway From tuxes to spacesuits — these days, you can really rent anything. That's the deal for NASA's anxiously-awaited and long-overdue Artemis lunar mission , which, as Space.com notes , will see astronauts walking the Moon in suits designed and rented out by the space tourism company Axiom Space. The NASA contractor showed off a prototype of its brand new spacesuit today — a design c
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Nearly eight years after its historic Pluto flyby, NASA's New Horizons probe is getting ready for another round of observations made from the icy edge of the solar system—and this time, its field of view will range from Uranus and Neptune to the cosmic background far beyond our galaxy.
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