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Lizards at US Army installation are stress eating during flyovers, shows study
Lizards may be small, with only a single hearing bonelet compared to our three, and without earflaps, but their hearing is typically good. Most lizards can hear frequencies between 100 and 5,000 Hz (although they are most sensitive between 400 and 1,500 Hz), compared to between 20 and 20,000 Hz in humans. So how do lizards react to noise pollution?



We worked alongside the CAS folks to contribute to this textbook, Modern Meat. All credit to Kris and his team over at CAS for this multi-year effort. If you're thinking about getting into the space or reading from folks doing the work, this is a great place to start.

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If you're wondering what AI will do to your job, look no further than the translation industry
Is this article about Entrepreneurship?

As a translator by trade who since moved on to greener pastures, I feel like I've seen the developments regarding generative AI before. Something very similiar happened a few years back, when neural networks lead to a big jump in the quality of machine translation output. Jobs in the translation industry have not been the same since, although the downward trend actually started a bit earlier than that.

I think it all began with the introduction of CAT (computer-aided translation) tools in the early 90s. These dissect texts into small chunks, often on the sentence level, and save them together with their translations in a database. If a similar segment shows up in a later text, the software fetches the previous translation and suggests using all or part of it, potentially saving the translator time and increasing their productivity.

Translators could now translate more text in less time, and for freelancers, this could also translate (ha) into higher income. But big translation agencies had something different in mind: They would use the productivity boost to lower their prices and undercut the competition in the hopes of attracting more customers.

Obviously, competing companies would do the same, so the rates translators could realistically ask for entered a downward spiral. When neural networks and translation tools like DeepL arrived, there already wasn't much left to disrupt.

A translator's income is now laughably low even in my home country Germany, where the profession has traditionally been highly regarded. Your only chance at making a decent living in the industry is to be a very skilled freelancer who offers additional services that are not as easily automated or if you start your own translation agency and pay other translators pennies instead.

Most employed translators now work as low-paid project managers, coordinating the translation process between the clients and a pool of freelancers instead of translating anything themselves. Those who actually do translate texts often have to pre-translate them using DeepL or similar tools and then try to salvage the results.

The combined household income of two people working in the translation industry often won't even get them into the middle class. Instead of increasing prosperity, technological progress destroyed it.

I think something similar will happen to other industries due to the proliferation of AI-based tools, but maybe I'm comparing apples with oranges? I'm interested to hear what others think about this example. Maybe there's some hope after all.

As a sidenote, I do think that some of the damage to the translation industry could have been mitigated if the translators would have actually fought back instead of just accepting the terms dictated by the big agencies. Unions in Germany are still comparatively strong, and there's a huge trade union that would have helped translators fight for better working conditions if they had been willing to become members. But alas, I don't know a single one who did, apart from myself.

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Capitalism is all about the free market, which means the level of innovation depends on demand and supply. And when there's high demand, companies get into fierce competition with each other, which is why we get new and improved products like the iPhone every year. But it's important to note that the middle class makes up the majority of buyers in this system. So, if AI takes over middle class jobs, these buyers won't have the same purchasing power, and that could cause a drop in innovation and profits for big companies .

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Fish diversity documented in Switzerland's rivers
In a major survey of Swiss rivers and streams, more than 50 different fish species were recorded. For the first time, more than one species was also found in the case of smaller types of fish such as the bullhead. In Progetto Fiumi, riverine fish were surveyed using standardized methods and both morphological and genetic characteristics were analyzed. Particularly high diversity was seen in large lowland rivers—where, however, near-natural reaches are rare.
How people move in front of an artwork can impact their experience
Is this article about Art?
A recent study led by University of Vienna psychologists has shed light on the impact of viewers' movements and positioning when looking at art. By tracking participants' movements, the researchers found that these movements could be clustered into four distinct groups, each associated with different art experiences. The study highlights the importance of considering physical engagement and bodily experience in the components of emotional and cognitive experiences of artworks.
Study finds COVID-19 pandemic increased, but also polarized, trust in science
Is this article about Biopharma Industry?
Research by the Milner Center for Evolution at the University of Bath, U.K., along with colleagues at Universities of Oxford and Aberdeen, finds that trust in scientists has hugely increased overall since the COVID-19 pandemic, but that attitudes have also become more polarized. The study also found that people were more likely to take the COVID-19 vaccine if their trust in the science had increased.
Is this article about Water Industry?
Membrane separation technology has become one of the most effective methods for water treatment, owing to its advantages of high separation efficiency, convenient operation and low-energy consumption. The membranes prepared from graphene oxide (GO) have received extensive attention for their high water permeability which is attributable to rapid water transport in the atomically smooth sp2 regions (non-oxidized regions) of their membrane channels.
In a major survey of Swiss rivers and streams, more than 50 different fish species were recorded. For the first time, more than one species was also found in the case of smaller types of fish such as the bullhead. In Progetto Fiumi, riverine fish were surveyed using standardized methods and both morphological and genetic characteristics were analyzed. Particularly high diversity was seen in large lowland rivers—where, however, near-natural reaches are rare.
Is this article about Agriculture?
A large portion of the nearly 200 million tons of single-use plastic produced globally ends up discarded as waste. The eventual breakdown of this plastic into microplastics—0.1–1000 µm-sized particles—is a cause for concern. Humans are exposed to microplastics not only through food consumption but also via inhalation, and their occurrence in the bloodstream and organs has already been documented.
Scientists shed light on how macrophages interact with microplastics
Is this article about Agriculture?
A large portion of the nearly 200 million tons of single-use plastic produced globally ends up discarded as waste. The eventual breakdown of this plastic into microplastics—0.1–1000 µm-sized particles—is a cause for concern. Humans are exposed to microplastics not only through food consumption but also via inhalation, and their occurrence in the bloodstream and organs has already been documented.
Dissecting the circadian clock in real time
As our bodies and minds continue to adjust to the recent time change, debates continue around society about whether to make daylight saving time a permanent fixture, eliminate it or stay with the current semi-annual clock adjustment.
Why flexible franchises win in financial markets
Is this article about Retail?
If you've stayed at a brand-name hotel or eaten at a fast food restaurant recently, it's more likely than not that you've supported a franchised company. Franchising is a distribution strategy where a larger company, the franchisor, licenses the rights to its brand, products, and procedures to a smaller establishment, the franchisee, in return for an initial fee and ongoing share of sales revenues.
Is this article about Neuroscience?


photosynthesis has evolved by repurposing enzymes found in C plants. Compared with the ancestral C state, accumulation of C cycle proteins is enhanced. We used de-etiolation of C Gynandropsis gynandra and C Arabidopsis thaliana to understand this process. C gene expression and chloroplast biogenesis in G. gynandra were tightly coordinated. Although C and C photosynthesis genes showed similar induction patterns, in G. gynandra , C genes were more strongly induced than orthologs from A. thaliana . In vivo binding of TGA and homeodomain as well as light-responsive elements such as G- and I-box motifs were associated with the rapid increase in transcripts of C genes. Deletion analysis confirmed that regions containing G- and I-boxes were necessary for high expression. The data support a model in which accumulation of transcripts derived from C photosynthesis genes in C leaves is enhanced because modifications in cis allowed integration into ancestral transcriptional networks.
Is this article about Cell?


Vaccines and drugs have helped reduce disease severity and blunt the spread of 
severe acute respiratory syndrome
 coronavirus 2 (SARS-CoV-2). However, ongoing virus transmission, continuous evolution, and increasing selective pressures have the potential to yield viral variants capable of resisting these interventions. Here, we investigate the susceptibility of natural variants of the main protease [M pro ; 3C-like protease (3CL pro )] of SARS-CoV-2 to protease inhibitors. Multiple single amino acid changes in M pro confer resistance to nirmatrelvir (the active component of Paxlovid). An additional clinical-stage inhibitor, ensitrelvir (Xocova), shows a different resistance mutation profile. Importantly, phylogenetic analyses indicate that several of these resistant variants have pre-existed the introduction of these drugs into the human population and are capable of spreading. These results encourage the monitoring of resistance variants and the development of additional protease inhibitors and other antiviral drugs with different mechanisms of action and resistance profiles for combinatorial therapy.


 (GBM) is the most common and aggressive primary brain 
. Despite multimodal treatment including surgery, radiotherapy, and chemotherapy, median patient survival has remained at ~15 months for decades. This situation demands an outside-the-box treatment approach. Using magnetic carbon nanotubes (mCNTs) and precision magnetic field control, we report a mechanical approach to treat chemoresistant GBM. We show that GBM cells internalize mCNTs, the mobilization of which by rotating magnetic field results in cell death. Spatiotemporally controlled mobilization of intratumorally delivered mCNTs suppresses GBM growth in vivo. Functionalization of mCNTs with anti-CD44 antibody, which recognizes GBM cell surface–enriched antigen CD44, increases mCNT recognition of cancer cells, prolongs mCNT enrichment within the tumor, and enhances therapeutic efficacy. Using mouse models of GBM with upfront or therapy-induced resistance to temozolomide, we show that mCNT treatment is effective in treating chemoresistant GBM. Together, we establish mCNT-based mechanical nanosurgery as a treatment option for GBM.


The blueprints of developing organs are preset at the early stages of embryogenesis. Transcriptional and epigenetic mechanisms are proposed to preset developmental trajectories. However, we reveal that the competence for the future cardiac fate of human embryonic stem cells (hESCs) is preset in pluripotency by a specialized mRNA translation circuit controlled by 
. RBPMS is recruited to active ribosomes in hESCs to control the translation of essential factors needed for cardiac commitment program, including Wingless/Integrated (WNT) signaling. Consequently, RBPMS loss specifically and severely impedes cardiac mesoderm specification, leading to patterning and morphogenetic defects in human cardiac organoids. Mechanistically, RBPMS specializes mRNA translation, selectively via 3′UTR binding and globally by promoting translation initiation. Accordingly, RBPMS loss causes translation initiation defects highlighted by aberrant retention of the EIF3 complex and depletion of EIF5A from mRNAs, thereby abrogating ribosome recruitment. We demonstrate how future fate trajectories are programmed during embryogenesis by specialized mRNA translation.


High-sensitivity organic photodetectors (OPDs) with strong near-infrared (NIR) photoresponse have attracted enormous attention due to potential applications in emerging technologies. However, few organic semiconductors have been reported with photoelectric response beyond ~1.1 μm, the detection limit of silicon detectors. Here, we extend the absorption of organic small-molecule semiconductors to below silicon bandgap, and even to 0.77 eV, through introducing the newly designed quinoid-terminals with high Mulliken-electronegativity (5.62 eV). The fabricated photodiode-type NIR OPDs exhibit detectivity ( ) over 10 12 Jones in 0.41 to 1.2 μm under zero bias with a maximum of 2.9 × 10 12 Jones at 1.02 μm, which is the highest for reported OPDs in photovoltaic-mode with response spectra beyond 1.1 μm. The high in 0.9 to 1.2 μm is comparable to those of commercial InGaAs photodetectors, despite the detection limit of our OPDs is shorter than InGaAs (~1.7 μm). A spectrometer prototype with a wide measurable region (0.4 to 1.25 μm) and NIR imaging under 1.2-μm illumination are demonstrated successfully in OPDs.


Controlled tissue growth is essential for multicellular life and requires tight spatiotemporal control over cell proliferation and differentiation until reaching homeostasis. As cells synthesize and remodel extracellular matrix, tissue growth processes can only be understood if the reciprocal feedback between cells and their environment is revealed. Using de novo–grown microtissues, we identified crucial actors of the mechanoregulated events, which iteratively orchestrate a sharp transition from tissue growth to maturation, requiring a myofibroblast-to-fibroblast transition. Cellular decision-making occurs when fibronectin fiber tension switches from highly stretched to relaxed, and it requires the transiently up-regulated appearance of tenascin-C and tissue transglutaminase, matrix metalloprotease activity, as well as a switch from α5β1 to α2β1 integrin engagement and epidermal growth factor receptor signaling. As myofibroblasts are associated with wound healing and inflammatory or fibrotic diseases, crucial knowledge needed to advance regenerative strategies or to counter fibrosis and cancer progression has been gained.


Intrinsic dual-emission (DE) of gold nanoclusters in the near-infrared (NIR) are fascinating for fundamental importance and practical applications, but their synthesis remains a formidable challenge and sophisticated excited-state processes make elucidating DE mechanisms much more arduous. Here, we report an all-alkynyl–protected gold nanocluster, Au20 , showing a prolate Au 12 tri-octahedral kernel surrounded by two Au (CZ-PrA) dimers, four Au(CZ-PrA) monomers, and two CZ-PrA − bridges. Au20 exhibits distinguished photophysical properties including NIR DE at 820 and 940 nm, microsecond radiative relaxation, and 6.26% photoluminescent quantum yield at ambient environment in nondegassed solution. Combining systematic studies on steady/transient spectroscopy and theoretical calculation, we identified two triplet charge transfer (CT) states, ligand-to-kernel and kernel-based CT states as DE origins. Furthermore, this NIR DE exhibits highly independent and sensitive response to surrounding environments, which well coincide with its mechanism. This work not only provides a substantial structure model to understand a distinctive DE mechanism but also motivates the further development of NIR DE materials.


Magnetocardiography (MCG), which uses high-sensitivity magnetometers to record magnetic field signals generated by electrical activity in the heart, is a noninvasive method for evaluating heart diseases such as arrhythmia and ischemia. The MCG measurements usually require the participant keeping still in a magnetically shielded room due to the immovable sensor and noisy external environments. These requirements limit MCG applications, such as exercise MCG tests and long-term MCG observations, which are useful for early detections of heart diseases. Here, we introduce a movable MCG system that can clearly record MCG signals of freely behaving participants in an unshielded environment. On the basis of optically pumped magnetometers with a sensitivity of 140 fT/Hz 1/2 , we successfully demonstrated the resting MCG and the exercise MCG tests. Our method is promising to realize a practical movable multichannel unshielded MCG system that nearly sets no limits to participants and brings another kind of insight into the medical diagnosis of heart disease.


Cell state plasticity is carefully regulated in adult epithelia to prevent cancer. The aberrant expansion of the normally restricted capability for cell state plasticity in 
 is poorly defined. Using genetically engineered and carcinogen-induced mouse models of intestinal neoplasia, we observed that impaired differentiation is a conserved event preceding cancer development. Single-cell RNA sequencing (scRNA-seq) of premalignant lesions from mouse models and a patient with hereditary polyposis revealed that cancer initiates by adopting an aberrant transcriptional state characterized by regenerative activity, marked by Ly6a (Sca-1), and reactivation of fetal intestinal genes, including Tacstd2 (Trop2). Genetic inactivation of Sox9 prevented adenoma formation, obstructed the emergence of regenerative and fetal programs, and restored multilineage differentiation by scRNA-seq. Expanded chromatin accessibility at regeneration and fetal genes upon Apc inactivation was reduced by concomitant Sox9 suppression. These studies indicate that aberrant cell state plasticity mediated by unabated regenerative activity and developmental reprogramming precedes cancer development.


Following peripheral nerve injury, extracellular adenosine 5′-triphosphate (ATP)–mediated purinergic signaling is crucial for spinal cord microglia activation and 
neuropathic pain
. However, the mechanisms of ATP release remain poorly understood. Here, we show that volume-regulated anion channel (VRAC) is an ATP-releasing channel and is activated by inflammatory mediator sphingosine-1-phosphate (S1P) in microglia. Mice with microglia-specific deletion of 
 (also known as Lrrc8a), a VRAC essential subunit, had reduced peripheral nerve injury–induced increase in extracellular ATP in spinal cord. The mutant mice also exhibited decreased spinal microgliosis, dorsal horn neuronal hyperactivity, and both evoked and spontaneous neuropathic pain–like behaviors. We further performed high-throughput screens and identified an FDA-approved drug dicumarol as a novel and potent VRAC inhibitor. Intrathecal administration of dicumarol alleviated nerve injury–induced mechanical allodynia in mice. Our findings suggest that ATP-releasing VRAC in microglia is a key spinal cord determinant of neuropathic pain and a potential therapeutic target for this debilitating disease.
Is this article about Circular Economy?


With the fast-growing accumulation of electronic waste and rising demand for rare metals, it is compelling to develop technologies that can promotionally recover targeted metals, like gold, from waste, a process referred to as urban mining. Thus, there is increasing interest in the design of materials to achieve rapid, selective gold capture while maintaining high adsorption capacity, especially in complex aqueous-based matrices. Here, a highly porous metal-organic framework (MOF)–polymer composite, BUT-33–poly( para -phenylenediamine) (PpPD), is assessed for gold extraction from several matrices including river water, seawater, and leaching solutions from CPUs. BUT-33–PpPD exhibits a record-breaking extraction rate, with high Au 3+ removal efficiency (>99%) within seconds (less than 45 s), a competitive capacity (1600 mg/g), high selectivity, long-term stability, and recycling ability. Furthermore, the high porosity and redox adsorption mechanism were shown to be underlying reasons for the material's excellent performance. Given the accumulation of recovered metallic gold nanoparticles inside, the material was also efficiently applied as a catalyst.
Is this article about Biopharma Industry?


Immune checkpoint inhibitors (ICIs) can reinvigorate T cells to eradicate tumor cells, showing great potential in combating various types of 
. We propose a delivery strategy to enhance tumor-selective ICI accumulation, which leverages the responsiveness of platelets and platelet-derivatives to coagulation cascade signals. A fused protein tTF-RGD targets tumor angiogenic blood vessel endothelial cells and initiates the coagulation locoregionally at the tumor site, forming a "cellular hive" to recruit anti–
 antibody (aPD-1)–conjugated platelets to the tumor site and subsequently activating platelets to release aPD-1 antibody to reactivate T cells for improved immunotherapy. Moreover, on a patient-derived xenograft breast cancer model, the platelet membrane–coated nanoparticles can also respond to the coagulation signals initiated by tTF-RGD, thus enhancing the accumulation and antitumor efficacy of the loaded chemotherapeutics. Our study illustrates a versatile platform technology to enhance the local accumulation of ICIs and chemodrugs by taking advantage of the responsiveness of platelets and platelet derivatives to 


During influenza virus entry, the hemagglutinin (HA) protein binds receptors and causes membrane fusion after endosomal acid activation. To improve vaccine efficiency and pandemic risk assessment for currently-dominant H3N2 influenza viruses, we investigated HA stability of 6 vaccine reference viruses and 42 circulating viruses. Recent vaccine reference viruses had destabilized HA proteins due to egg-adaptive mutation HA1-L194P. Virus growth in cell culture was independent of HA stability. In ferrets, the vaccine reference viruses and circulating viruses required a relatively stable HA (activation and inactivation pH < 5.5) for airborne transmissibility. The recent vaccine reference viruses with destabilized HA proteins had reduced infectivity, had no airborne transmissibility unless reversion to HA1-P194L occurred, and had skewed antigenicity away from the studied viruses and circulating H3N2 viruses. Other vaccine reference viruses with stabilized HAs retained infectivity, transmissibility, and antigenicity. Therefore, HA stabilization should be prioritized over destabilization in vaccine reference virus selection to reduce mismatches between vaccine and circulating viruses.
Is this article about Neuroscience?


The catalytic dearomative cycloaddition of bicyclic heteroaromatics including benzofurans and indoles provides rapid access to functionalized heterocyclic molecules. Because of the inherent stereoelectronic differences, the furan or pyrrole nucleus is more prone to dearomative cycloaddition than the benzene ring. Here, we realized a geometry-based differentiation approach for achieving C6-C7 and C7-C7a regioselectivity. The rotationally restricted σ bond at C7 position respectively placed the C6-C7 and C7-C7a sites of benzofurans or indoles in an optimal spatial orientation toward the axially chiral heterodiene, thus affording two enantioenriched polycyclic compounds from a single racemic heterobiaryl atropisomers. Calculation results of density functional theory interpreted the mechanism of this parallel kinetic resolution. The bioactivity of the dearomatized products was evaluated in cancer cell lines with certain compounds exhibiting interesting biological activities.
Is this article about Food Science?


We introduce a cost-effective, robust high-throughput–compatible plasma depletion method enabling in-depth profiling of plasma that detects >1300 proteins per run with a throughput of 60 samples per day. The method has been fully validated by processing >3000 samples with no apparent batch effect at a cost for the depletion step of ~$2.5 per sample.


The serine palmitoyltransferase (SPT) complex catalyzes the first and rate-limiting step in sphingolipid biosynthesis in all eukaryotes. ORM/ORMDL proteins are negative regulators of SPT that respond to cellular sphingolipid levels. However, the molecular basis underlying ORM/ORMDL-dependent homeostatic regulation of SPT is not well understood. We determined the cryo–electron microscopy structure of Arabidopsis SPT-ORM1 complex, composed of LCB1, LCB2a, SPTssa, and ORM1, in an inhibited state. A ceramide molecule is sandwiched between ORM1 and LCB2a in the cytosolic membrane leaflet. Ceramide binding is critical for the ORM1-dependent SPT repression, and dihydroceramides and phytoceramides differentially affect this repression. A hybrid β sheet, formed by the amino termini of ORM1 and LCB2a and induced by ceramide binding, stabilizes the amino terminus of ORM1 in an inhibitory conformation. Our findings provide mechanistic insights into sphingolipid homeostatic regulation via the binding of ceramide to the SPT-ORM/ORMDL complex that may have implications for plant-specific processes such as the hypersensitive response for microbial pathogen resistance.


Human value–based decisions are notably variable under uncertainty. This variability is known to arise from two distinct sources: variable choices aimed at exploring available options and imprecise learning of option values due to limited cognitive resources. However, whether these two sources of decision variability are tuned to their specific costs and benefits remains unclear. To address this question, we compared the effects of expected and unexpected uncertainty on decision-making in the same reinforcement learning task. Across two large behavioral datasets, we found that humans choose more variably between options but simultaneously learn less imprecisely their values in response to unexpected uncertainty. Using simulations of learning agents, we demonstrate that these opposite adjustments reflect adaptive tuning of exploration and learning precision to the structure of uncertainty. Together, these findings indicate that humans regulate not only how much they explore uncertain options but also how precisely they learn the values of these options.


MYCN amplification in neuroblastoma leads to aberrant expression of MYCN oncoprotein, which binds active genes promoting transcriptional amplification. Yet, how MYCN coordinates transcription elongation to meet productive transcriptional amplification and which elongation machinery represents MYCN-driven vulnerability remain to be identified. We conducted a targeted screen of transcription elongation factors and identified the super elongation complex (SEC) as a unique vulnerability in MYCN -amplified 
. MYCN directly binds EAF1 and recruits SEC to enhance processive transcription elongation. Depletion of EAF1 or AFF1/AFF4, another core subunit of SEC, leads to a global reduction in transcription elongation and elicits selective apoptosis of MYCN -amplified neuroblastoma cells. A combination screen reveals SEC inhibition synergistically potentiates the therapeutic efficacies of FDA-approved BCL-2 antagonist ABT-199, in part due to suppression of MCL1 expression, both in MYCN -amplified neuroblastoma cells and in patient-derived xenografts. These findings identify disruption of the MYCN-SEC regulatory axis as a promising therapeutic strategy in neuroblastoma.
Is this article about Political Science?


Previous studies have highlighted how African genomes have been shaped by a complex series of historical events. Despite this, genome-wide data have only been obtained from a small proportion of present-day ethnolinguistic groups. By analyzing new autosomal genetic variation data of 1333 individuals from over 150 ethnic groups from Cameroon, Republic of the Congo, Ghana, Nigeria, and Sudan, we demonstrate a previously underappreciated fine-scale level of genetic structure within these countries, for example, correlating with historical polities in western Cameroon. By comparing genetic variation patterns among populations, we infer that many northern Cameroonian and Sudanese groups share genetic links with multiple geographically disparate populations, likely resulting from long-distance migrations. In Ghana and Nigeria, we infer signatures of intermixing dated to over 2000 years ago, corresponding to reports of environmental transformations possibly related to climate change. We also infer recent intermixing signals in multiple African populations, including Congolese, that likely relate to the expansions of Bantu language–speaking peoples.
Is this article about Weather?


Arc-continent collision in Southeast Asia during the Neogene may have driven global cooling through chemical weathering of freshly exposed ophiolites resulting in atmospheric CO removal. Yet, little is known about the cause-and-effect relationships between erosion and the long-term evolution of tectonics and climate in this region. Here, we present an 8-million-year record of seawater chemistry and sediment provenance from the eastern Indian Ocean, near the outflow of Indonesian Throughflow waters. Using geochemical analyses of foraminiferal shells and grain size–specific detrital fractions, we show that erosion and chemical weathering of ophiolitic rocks markedly increased after 4 million years (Ma), coincident with widespread island emergence and gradual strengthening of Pacific zonal sea-surface temperature gradients. Together with supportive evidence for enhanced mafic weathering at that time from re-analysis of the seawater 87 Sr/ 86 Sr curve, this finding suggests that island uplift and hydroclimate change in the western Pacific contributed to maintaining high atmospheric CO consumption throughout the late Neogene.
Is this article about Neuroscience?


We show that a binary oncolytic/helper-dependent adenovirus (CAdVEC) that both lyses tumor cells and locally expresses the proinflammatory cytokine IL-12 and PD-L1 blocking antibody has potent antitumor activity in humanized mouse models. On the basis of these preclinical studies, we treated four patients with a single intratumoral injection of an ultralow dose of CAdVEC (NCT03740256), representing a dose of oncolytic adenovirus more than 100-fold lower than used in previous trials. While CAdVEC caused no significant toxicities, it repolarized the tumor microenvironment with increased infiltration of CD8 T cells. A single administration of CAdVEC was associated with both locoregional and abscopal effects on metastases and, in combination with systemic administration of immune checkpoint antibodies, induced sustained antitumor responses, including one complete and two partial responses. Hence, in both preclinical and clinical studies, CAdVEC is safe and even at extremely low doses is sufficiently potent to induce significant tumor control through oncolysis and immune repolarization.


Protein filaments are used in myriads of ways to organize other molecules within cells. Some filament-forming proteins couple the hydrolysis of nucleotides to their polymerization cycle, thus powering the movement of other molecules. These filaments are termed cytomotive. Only members of the actin and tubulin protein superfamilies are known to form cytomotive filaments. We examined the basis of cytomotivity via structural studies of the polymerization cycles of actin and tubulin homologs from across the tree of life. We analyzed published data and performed structural experiments designed to disentangle functional components of these complex filament systems. Our analysis demonstrates the existence of shared subunit polymerization switches among both cytomotive actins and tubulins, i.e., the conformation of subunits switches upon assembly into filaments. These cytomotive switches can explain filament robustness, by enabling the coupling of kinetic and structural polarities required for cytomotive behaviors and by ensuring that single cytomotive filaments do not fall apart.
Companies Are Paying Bonkers Salaries for People Good at ChatGPT
While the rest of the world is concerned about ChatGPT coming to take their jobs, some companies are paying six figures to people who are really good at it.

Six Figures

While the rest of the world is rightfully concerned about 


 coming to take their jobs, some companies are offering six-figure salaries to a select few who are great at wringing results out of next-gen AI chatbots.

As Bloomberg reports, some companies are offering salaries of up to a sizzling $335,000 per annum for so-called "prompt engineer" positions. In essence, these are supposed to be ChatGPT wizards who are so good at the tech that they can train other people on how to use it more effectively.

Albert Phelps, one of these lucky prompt engineers who works at a subsidiary of the Accenture consultancy firm in the UK, told Bloomberg that the job entails being something of an "AI whisperer," regardless of educational background, with folks who have degrees as disparate as history, philosophy, or English.

"It's wordplay," he said. "You're trying to distill the essence or meaning of something into a limited number of words."

Phelps himself, at only 29, studied history before beginning a career in financial consulting and ultimately pivoting to AI. On a given day at his job, the youthful AI wizard and his colleagues will write about five different prompts and have 50 individual interactions with large language models like ChatGPT.

Growth Market

While there's been a proliferation of low-hanging fruit gigs — there's even a freelance prompt engineer marketplace similar to Fiverr called PromptBase, where people sell their prompt-writing skills for $3-10 a pop — those who get particularly good at writing prompts can draw huge salaries.

Just take it from Mark Standen, the owner of an AI, automation, and machine learning staffing business in the UK and Ireland, who told Bloomberg that prompt engineering is "probably the fastest-moving IT market I've worked in for 25 years."

"Expert prompt engineers can name their price," Standen said, noting that while the jobs start at the pound sterling equivalent of about $50,000 per year in the UK, there are candidates in his company's database looking for between $250,000 and $360,000 per year.

The Bloomberg report notes that naturally, there's no way to know when or if the bubble will burst on this newly-created title, but all the same, earning a six-figure salary to write chatbot prompts, even for just a year or two, sounds a lot better than losing your job to AI.

More on chatbots: That Startup Run by ChatGPT Doesn't Seem to Be Doing So Great

The post Companies Are Paying Bonkers Salaries for People Good at ChatGPT appeared first on Futurism.

Goldman Sachs Salivates at AI's Potential to Mass Fire Workers
Is this article about Future of Work?
Goldman Sachs wants you to replace your costly human labor force with generative AI. Look on the bright side, though: huge savings.
Goldman Sachs

 wants their customers to know that they should be very excited about generative AI — because generative AI tools could let 'em fire human workers and replace them with AI en masse. Hooray!

"The recent emergence of generative artificial intelligence (AI) raises whether we are on the brink of a rapid acceleration in task automation that will drive labor cost savings and raise productivity," reads a new Goldman Sachs economic report, published over the weekend.

"Despite significant uncertainty around the potential of generative AI," it continues, "its ability to generate content that is indistinguishable from human-created output and to break down communication barriers between humans and machines reflects a major advancement with potentially large macroeconomic effects."

Translation? While the future of generative AI is still up in the air, right now, its output is already comparable, in the bank's eyes, to the output of enormously costly human labor. Replace humans with machines, and you no longer have to pay for livelihoods — just subscription fees.

Perhaps most chillingly, the Goldman Sachs report describes generative AI as a "disruption" to the "labor market." And sure, it may well be, but the term "disruption" is usually used to describe significant changes within certain industries, particularly when something new replaces and upends something old. Goldman Sachs is seemingly speaking to the concept of human jobs altogether — a presumably less manageable workforce shift.

In other words, a significant disruption indeed, and one that will cause a significant amount of pain for the masses in turn.

"Using data on occupational tasks in both the US and Europe, we find that roughly two-thirds of current jobs are exposed to some degree of AI automation, and that generative AI could substitute up to one-fourth of current work," reads the report. "Extrapolating our estimates globally suggests that generative AI could expose the equivalent of 300 [million] full-time jobs to automation." Gulp.

The report did throw us peasants a bone, echoing a common refrain heard among AI optimists: that AI will replace jobs, but that human society has always adjusted to new technologies over time. Laborers flock to different jobs, and at the same time, new jobs are created, in the short term as well as in the long run. Look how far we've come since the birth of the computer, after all.

"The good news," reads the report, "is that worker displacement from automation has historically been offset by creation of new jobs, and the emergence of new occupations following technological innovations accounts for the vast majority of long-run employment growth."

Historically speaking, it's a fair point — but one, we gotta say, that definitely dissociates a bit from the immediate pain that eliminating an estimated 300 million jobs will cause. There's also the reality that those who repeat that line — OpenAI CEO Sam Altman included in that line-up — have little to offer in terms of what those generative AI-created roles might look like, and when we might expect to see them crop up.

We're all walking into a new technological unknown, and we can't expect AI innovators to have all of the answers. But still, it's hard to take Goldman Sachs' rosy "good news" outlook seriously when it tends to read more like an excuse to do something, like intentionally eradicate hundreds of millions of jobs, rather than a sound, substance-driven reason that goes beyond just keeping cash in a company's bank, as opposed to its workers' pockets.

And to that end, the Goldman Sachs report did round out that "good news" nugget with a sobering piece of economic wisdom: that while there might be an economic growth-inducing "productivity boom" driven by "the combination of significant labor cost savings, new job creation, and higher productivity for non-displaced workers," the "timing of such a boom is hard to predict."

So, you know, good stuff will happen for everyone, probably — just can't tell ya when!

None of this is all that surprising, given that most big employers out there are constantly looking to cut costs of all kinds, labor included. And elsewhere, technology, as mentioned above, has always changed industries, and with that, changed, eliminated, and created jobs.

But that takes time, and generative AI is moving at a lightning-fast pace, with an incredible amount of money behind it to boot. Only time will tell how quickly the "good news" that Goldman Sachs and others have promised will follow.

READ MORE: The Potentially Large Effects of Artificial Intelligence on Economic Growth [Goldman Sachs]

More on banks and generative AI: Bank of America Obsessed with AI, Says It's the "New Electricity"

The post Goldman Sachs Salivates at AI's Potential to Mass Fire Workers appeared first on Futurism.

OpenAI CEO: It's Not Funny That I'm Afraid of the AI We're Creating
Is this article about Tech?
The CEO of OpenAI has admitted that he's afraid of the artificial intelligence his company is ushering in — but he doesn't think you should laugh about it.

Be Afraid

The CEO of 


 has admitted repeatedly that he's scared of the tech his company is cooking up — but he doesn't think you should make fun of him for it.

"I think it's weird when people think it's like a big dunk that I say, I'm a little bit afraid," OpenAI CEO and noted doomsday prepper Sam Altman told podcaster Lex Fridman in an episode dropped this past weekend. "And I think it'd be crazy not to be a little bit afraid, and I empathize with people who are a lot afraid."

While Altman iterated during his Fridman show appearance that his concerns are primarily "disinformation problems or economic shocks" and not algorithmic "superintelligence," he has said a bunch of stuff recently that suggests that he's more than a little wigged out about AI.

Take, for instance, his recent comments to ABC News: "A thing that I do worry about is… [OpenAI is not] not going to be the only creator of this technology."

"There will be other people who don't put some of the safety limits that we put on it," Altman added.

Take Care

While it seems legit to worry about less-ethical competitors (which is kind of ironic given everything we know about OpenAI) or about the "potentially scary" AIs that will follow his company's current offerings, the comments he's referring to — when he told Fox News that it's a good thing that he has trepidations about what he's created — are pretty eyebrow-raising, even in spite of his attempts to downplay them.

"We've got to be careful here," Altman told the news network earlier in March. "I think people should be happy that we are a little bit scared of this."

While it certainly is good that there are concerns at the top of OpenAI about what may come of artificial intelligence, it doesn't exactly inspire confidence that the CEO has been repeatedly quoted saying he's scared of it — and no amount of couching language will change how weird or funny that is, because if we can't laugh while the world burns, then what else can we do?

More on AI feelings: CEO of OpenAI Says Elon Musk's Mean Comments Have Hurt Him

The post OpenAI CEO: It's Not Funny That I'm Afraid of the AI We're Creating appeared first on Futurism.

Cohesin is a ring-shaped protein that surrounds and moves around the DNA molecule, forming the loops. It is a crucial process for the cell. Understanding how cohesin works has been one of the challenges of molecular biology in recent decades. A study now published by researcher Ana Losada's group at The Spanish National Cancer Research Centre (CNIO) will serve to deepen our understanding of the disease known as 
Cornelia de Lange syndrome
COVID-19 causes chaos in infected cells' RNA, finds study
 disease (COVID-19) hijacks parts of infected cells' vital RNA machinery, thereby blocking important functions in the cells. These damaging changes in the RNA can likely be reversed, potentially leading to new drugs against COVID-19, University of Gothenburg researchers show.
Cohesin is a ring-shaped protein that surrounds and moves around the DNA molecule, forming the loops. It is a crucial process for the cell. Understanding how cohesin works has been one of the challenges of molecular biology in recent decades. A study now published by researcher Ana Losada's group at The Spanish National Cancer Research Centre (CNIO) will serve to deepen our understanding of the disease known as 
Cornelia de Lange syndrome
Corruption episodes haunt democracies for decades, study finds
Is this article about Politics?
The short-term effects of corruption are often obvious. Numerous sources, both in Russia and in the West, consider the military's endemic corruption one of the main reasons of the logistical problems, very low troop morale, and massive casualties of the Red Army in Ukraine. In late 2016, a corruption scandal cost the first woman elected head of state in an Asian country, South Korea's Park Geun-hye, impeachment.
Is this article about Social Engineering?

Nature Communications, Published online: 29 March 2023; doi:10.1038/s41467-023-37248-8

The SHANK3 gene is linked to autism spectrum disorder and Phelan McDermid syndrome, which have been associated with social memory deficits. Here, authors show activation of the hippocampal CA2-ventral 
 circuit in adult Shank3B knockout mice restores social memory.
Work isn't just about getting paid. Employment can provide a number of benefits for people in terms of health, well-being, social, economic and financial inclusion. It can also reduce reliance on government income supports. Arguably, work is even more important for people with disability, who are more likely to be in lower socioeconomic groups and socially isolated.
Stereotypes about senior employees can lead to premature retirements
Unproductive, inflexible, and less motivated… these are some of the most common stereotypes heard about senior employees. Even though the stereotypes are usually unfounded, they nevertheless influence how senior employees perceive themselves and their status in the workplace. And they thus become a key factor in many senior employees' retirement decisions, conclude University of Copenhagen researchers in a new study published in PLOS ONE.
If you look at where wombats deposit their poo, you realize they must be able to perform some surprising acrobatics. It has always amazed me to see wombat scats on top of grass tussocks or logs, because I've always wondered how the stocky creatures must have maneuvered themselves to put it there.
What is antisocial behavior? According researcher, no one really knows
Prime Minister Rishi Sunak has unveiled plans to crack down on antisocial behavior. The proposals include making offenders wear hi-vis jackets to wash police cars and clean up vandalism, within 48 hours of being served a court order. Offenders may have to do other unpaid work in their local communities.
Is this article about Climate?
When news about the climate is published, like the Intergovernmental Panel on Climate Change's latest report, frightening headlines like "final warning" or "now or never" are often the norm. Some activists call this approach "climate doomism", and are quick to criticize media publications and other influencers for it. Climate doomism is the view that humanity has lost the climate battle, and we feel nothing but helplessness and anxiety about it.
A method to make inorganic membranes on the surface of aqueous solutions
Is this article about Electronics?

Nature, Published online: 29 March 2023; doi:10.1038/d41586-023-00730-w

A generalizable technique has been developed to create diverse functional inorganic membranes on the surface of various aqueous solutions. The technique ensures that the air–liquid interface receives a continuous supply of floating particles, which then assemble dynamically to form continuous membranes.
A Collection of Cherry Blossoms
Is this article about Gardening?

Spring started a little more than a week ago, and the Northern Hemisphere has begun to warm; flowers and trees are blooming. Gathered below are some recent images of people enjoying themselves among groves of flowering cherry-blossom trees in Tokyo; Munich; Washington, D.C.; and more—signs of warmer days to come.

'Data project life cycle' approach proposed for preparing students
In the age of big data, information is everywhere. But it takes a skilled data interpreter and communicator to help people understand what information means and why it is important. To help ensure future journalists and communicators know how to find, make sense of and share data—and counter misinformation—two University of Kansas researchers have proposed a "data project life cycle" approach to preparing students.
High Blood Pressure May Cause Dementia, Scientists Say
A new study mapped how high blood pressure affects regions of the brain from over 30,000 patients, showing changes also linked to dementia.

Scientists have long been aware of a worrying link between 

high blood pressure

 and the onset of 



But now, in a new study published in the European Heart Journal, researchers have mapped how high blood pressure affects specific regions of the brain, unearthing the best evidence yet that the two conditions are indeed connected.

In fact, high blood pressure may even be a direct cause of brain dysfunction, they suggest.

"Our study has, for the first time, identified specific places in the brain that are potentially causally associated with high blood pressure and cognitive impairment," said study lead author Mateusz Siedlinski, a researcher at the Jagiellonian University Medical College, in a press release.

Siedlinski and his team parsed through MRI brain scans paired with genetic data from over 30,000 patients in the UK Biobank medical database.

By using Mendelian randomization, a technique that eliminates confounding factors by focusing on genes that could predispose a person to certain conditions, the team found that nine parts of the brain exhibited changes related to both higher blood pressures and a decline in cognitive function.

To eliminate any room for doubt, the researchers then double-checked their findings with a separate batch of patients in Italy.

"In our study, if a gene that causes high blood pressure is also linked to certain brain structures and their function, then it suggests that high blood pressure might really be causing brain dysfunction at that location, leading to problems with memory, thinking and dementia," explained study co-author Tomasz Guzik, a professor of cardiovascular medicine at the University of Edinburgh, in the release.

There is one nagging caveat, though: since most of the participants were white and middle-aged, the researchers note that it "might not be possible to extrapolate the findings to older people," according to the statement.

Nevertheless, of the parts they observed to be affected, the putamen and the anterior thalamic radiation were the most notable. The putamen, located in the front of the brain, is responsible for controlling movement and facilitating learning, while the latter is in charge of executive functions like planning tasks. Various regions of white matter, the tissue responsible for connecting different parts of the brain, were also found to be affected.

The researchers estimate that around 30 percent of the global population suffers from high blood pressure, which, based on their findings, puts a hefty helping of us at risk of dementia.

Troubling a find as it may be, it's no doubt a welcome clue in treating the condition, especially since the cause of its most devastating form, Alzheimer's disease, remains largely unknown.

"It has been known for a long time that high blood pressure is a risk factor for cognitive decline, but how high blood pressure damages the brain was not clear," said co-author Joanna Wardlaw, a neuroscientist at the University of Edinburgh, in the release.

"This study shows that specific brain regions are at particularly high risk of blood pressure damage, which may help to identify people at risk of cognitive decline in the earliest stages, and potentially to target therapies more effectively in future," she added.

More on dementia: Paparazzi Won't Stop Harassing Bruce Willis Even Though He Has Dementia

The post High Blood Pressure May Cause Dementia, Scientists Say appeared first on Futurism.

Scientists discover hidden crab diversity among coral reefs
The Indo-West Pacific is the largest, most biodiverse marine ecosystem on Earth, and many of the species it supports have comparably wide ranges. Writing in The Origin of Species, Charles Darwin noted that "… many fish range from the Pacific into the Indian Ocean, and many shells are common to the eastern islands of the Pacific and the eastern shores of Africa, on almost exactly opposite meridians of latitude."
The Indo-West Pacific is the largest, most biodiverse marine ecosystem on Earth, and many of the species it supports have comparably wide ranges. Writing in The Origin of Species, Charles Darwin noted that "… many fish range from the Pacific into the Indian Ocean, and many shells are common to the eastern islands of the Pacific and the eastern shores of Africa, on almost exactly opposite meridians of latitude."
FTX Founder Suffers Personal Nightmare as Courts Cut Him Off From League of Legends
As a result of newly-tightened bail restrictions, Former FTX CEO Sam Bankman-Fried is no longer allowed to play his favorite videogame. Brutal.

Extra Grounded

Disgraced cryptocurrency exchange CEO Sam Bankman-Fried just moved into a new circle of personal house-arrest hell.

Until now, the former head of 


 has enjoyed a relatively cozy at-home arrest at his parent's $3.5 million-plus Palo Alto home, spending his days playing with his new guard dog, writing long-winded Substack posts about how FTX was actually still solvent at the time of his arrest, and so on.

Most importantly, he's been able to play the popular video game 

League of Legends

, his passion for which is, for lack of a better word, legendary. The former CEO has taken to Twitter a number of times to discuss his obsession with the cult-status game, and, according to lore, once played the game throughout the duration of a massively important pitch meeting with the investment firm Sequoia.

But sadly, it appears that his League of Legends days are officially over.

On Monday, prosecutors in the case against the former crypto wunderkind issued stricter bail requirements, which, among a number of other restrictions, bar the accused fraudster from playing any videogames that, like League of Legends, "permit chat or voice communication."


Flip Phone

The new court-issued guidelines also restrict the founder to the use of a single, court-issued laptop, on which Bankman-Fried is only allowed to browse "pre-approved" websites, a list that includes all ".gov" sites as well as YouTube, Wikipedia, and several blockchain-trackers. Most major news sites are also still on the table, as are food delivery services — a bright spot on a dark day for the Doordash-stanning Bankman-Fried.

His smartphone has also been taken and replaced with an Uncle Sam-approved flip phone. And though his parents, who are both Stanford professors, are allowed to keep and use their personal devices freely, their son is NOT to access them, and all visitors to the house have to agree to hand their devices over to security guards upon entering the home.

We'd be lying if we said we weren't a little bit bummed about the fact that SBF is no longer allowed on Substack, as we would have loved reading a rambling SBF newsletter about those new charges accusing him of spending $40 million to successfully bribe Chinese authorities — a revelation that we're sure has nothing to do with this newly-tightened government leash.

But allegations aside, Futurism is not on the government-approved list, so SBF likely won't be reading this anyways.

READ MORE: SBF Cut Off From His Favorite Toys Under New Proposed Bail Conditions [Gizmodo]

More on SBF: FTX's New CEO Says Company Did "Old Fashioned Embezzlement"

The post FTX Founder Suffers 

Personal Nightmare



 Cut Him Off From League of Legends appeared first on Futurism.

It's time to rethink what citizen science really is, say researchers
Is this article about Tech & Scientific Innovation?
Citizen science is a popular method of gathering data for natural and social scientists, with the number of projects and publications produced growing year by year. A typical citizen science project uses volunteers to gather data that would otherwise be unaffordable or inaccessible.
As a deadly tornado headed toward Rolling Fork, Mississippi, on March 24, 2023, forecasters saw the storm developing on radar and issued a rare "tornado emergency" warning. NOAA's Weather Prediction and Storm Prediction centers had been warning for several days about the risk of severe weather in the region. But while forecasters can see the signs of potential tornadoes in advance, forecasting when and where tornadoes will form is still extremely difficult.
Experiment finds gluon mass in the proton
Nuclear physicists may have finally pinpointed where in the proton a large fraction of its mass resides. A recent experiment carried out at the U.S. Department of Energy's Thomas Jefferson National Accelerator Facility has revealed the radius of the proton's mass that is generated by the strong force as it glues together the proton's building block quarks. The result was recently published in Nature.
Turbulence theory extended to complex atmospheric conditions
Turbulence plays an essential role in weather and climate, and correctly representing its effects in numerical models is crucial for accurate weather forecasts and climate projections. However, the theory describing the effect of turbulence has not changed since its conception in 1950s, despite the fact that it is not representative for the majority of the Earth's land surface, especially over mountains and polar regions. The Innsbruck meteorologist Ivana Stiperski has now extended the turbulence theory to complex atmospheric conditions. The researcher thus paves the way for the first generalized turbulence theory over complex terrain.
Scientists apply Raman quantitative 3D imaging to microbial monitoring
Microorganisms are important contributors to the deep-sea sulfur cycle. However, in-situ detection of deep-sea microorganisms faces great challenges due to the extreme complexity of the deep-sea environment, the difficulty of sampling, isolation and cultivation of microorganisms, and the lack of near real-time nondestructive monitoring methods for microbial sulfur metabolism.
"There's no doubt we can produce enough food for the world's population—humanity is strategic enough to achieve that. The question is whether—because of war and conflict and corruption and destabilization—we do," said World Food Program leader David Beasley in an interview with Time magazine earlier this year.
Microorganisms are important contributors to the deep-sea sulfur cycle. However, in-situ detection of deep-sea microorganisms faces great challenges due to the extreme complexity of the deep-sea environment, the difficulty of sampling, isolation and cultivation of microorganisms, and the lack of near real-time nondestructive monitoring methods for microbial sulfur metabolism.
Exclusive: Committee recommended pulling several papers by former Cornell med school dean
Augustine M. K. Choi

Following an investigation launched by 

Cornell University

, a committee recommended pulling several papers by lung-disease researcher Augustine M. K. Choi, who served as dean of Weill Cornell Medicine until this year, Retraction Watch has learned.

Choi's latest retraction, which brings him up to three so far,  came on March 15, when The Journal of Clinical Investigation pulled "UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis." The paper has been cited 178 times, according to Clarivate's Web of Science. 

The retraction notice reads: 

Cornell University, Harvard Medical School, and Brigham and Women's Hospital jointly notified the JCI that Figures 3A, 4D, 7B, and 8B and Supplemental Figures 4 and 7A are not reliable. In accordance with the institutional recommendations, the JCI is retracting this article.

Choi served as dean of Weill Cornell Medicine and provost of medical affairs at Cornell University from 2017 to 2022. He has been a professor of both medicine and genetic medicine at Weill Cornell Medical College since 2014. 

As we reported earlier, Choi had a paper retracted and then republished in 2015. Five years later, in 2020, he lost another article "due to inclusion of data that were published previously … and represent different results." That same year, commenters on PubPeer started flagging potential image problems in several of Choi's other publications.

Following the latest retraction, we reached out to Cornell, Harvard, and Brigham and Women's for comment on the recommendations the notice refers to. No one from Harvard replied and a spokesperson from Brigham and Women's declined to comment, deferring to Cornell. Joel M. Malina, Cornell University vice president for university relations, told us: 

In 2020, Cornell learned of data integrity inquiries involving research published out of Dr. Choi's laboratory. Cornell launched an independent investigation at that time, conducted by a committee of preeminent scientists from outside of Cornell and led by external counsel, which resulted in a detailed analysis of a number of publications and a thorough review of lab practices. The final report found that Dr. Choi did not commit research misconduct. The report made recommendations for retraction of several papers because certain figures were not reliable and, given the absence of original data, the scientific record could not be corrected. Retraction is consistent with academic norms in such circumstances.

Malina did not directly say whether Choi's leaving of his dean and provost positions was influenced by the investigation, but he said that Choi ultimately chose not to seek another term in these positions. Malina also highlighted the contributions Choi has made to Cornell, including his leadership during the pandemic and establishing a debt-free tuition plan for medical students. 

Choi did not respond to an email from Retraction Watch.

Like Retraction Watch? You can make a tax-deductible contribution to support our work, follow us on Twitter, like us on Facebook, add us to your RSS reader, or subscribe to our daily digest. If you find a retraction that's not in our database, you can let us know here. For comments or feedback, email us at


A gene drive is a gene drive: the debate over lumping or splitting definitions

Nature Communications, Published online: 29 March 2023; doi:10.1038/s41467-023-37483-z

We address a controversy over use of the term "gene drive" to include both natural and synthetic genetic elements that promote their own transmission within a population, arguing that this broad definition is both practical and has advantages for risk analysis.

Nature Communications, Published online: 29 March 2023; doi:10.1038/s41467-023-37463-3

The neural mechanisms underpinning ketamine's dissociative and antidepressant effects remain poorly understood. Here, the authors analyzed ketamine-induced brain dynamics with intracranial recordings in humans and found that ketamine engages different brain areas in distinct frequency-dependent patterns that may relate to its dissociative and antidepressant effects.
Study finds sulfate pollution impacts Texas gulf coast air
Sitting on the beach, taking in the breeze, you might think the sea air is better for you than its inland equivalent. But researchers at the University of Houston have found that the air along the Gulf of Mexico coast in Texas can be more polluted due to its highly processed and acidic chemical components of particulate matter, which are microscopic solid or liquid particles in the air.
How did the orchid mantis adapt and evolve?
Researchers from the Xishuangbanna Tropical Botanical Garden (XTBG) of the Chinese Academy of Sciences recently presented the first study systematically investigating basic biological traits of a classic conspicuous masquerader, the orchid mantis.
Is this article about Cell?
Climate projection requires an accurate understanding for the decomposition of soil organic carbon (SOC) and its response to warming. However, the wide array of organic molecules in the soil exhibits distinct chemical structures and kinetic properties, making it difficult to unravel the conundrum of SOC stability and response to warming.
Researchers synthesize N and P co-doping catalysts
Recently, the team from Institute of Solid State Physics, Hefei Institutes of Physical Science of the Chinese Academy of Sciences, made a breakthrough in the research of non-metallic heteroatom doping to regulate catalytic performance. The researchers synthesized N and P co-doping carbon-coated cobalt-based catalysts (Co@NPC) and explored the effect of heteroatom doping in the catalyst on the selective hydrogenation of cinnamaldehyde. The study was published in the Journal of Catalysis.
Is this article about Cell?
Climate projection requires an accurate understanding for the decomposition of soil organic carbon (SOC) and its response to warming. However, the wide array of organic molecules in the soil exhibits distinct chemical structures and kinetic properties, making it difficult to unravel the conundrum of SOC stability and response to warming.
"The Future of Humans: How Technology, Climate Change, and Demographic Shifts Could Shape Our Destiny"

Are you curious about what the future might hold for us? From advancements in technology and space exploration to shifts in social and environmental landscapes, futurology offers a glimpse into the possibilities that await us. Check out my link to explore the latest trends and predictions in futurology, and discover how they could shape our world in the coming years. With so much on the horizon, now is the perfect time to dive into this exciting field and prepare for what's to come. Don't miss out on the opportunity to expand your horizons and explore the potential of the future.

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[link] [comments]
Is capitalism REALLY going to disappear?

I see the argument of "robots will automate jobs so capitalism can't survive" a lot, and tbh i think it's a very weak argument. However i am open to being wrong and would more than welcome any counter arguments.

just because no one is working doesn't mean that capitalism will suddenly collapse. that makes 0 sense and i can't see why anyone would think that. To me it feels like wishful thinking or maybe just ignorance of reality. Companies will still sell products, bills will still have to be paid, money will still have to be exchanged (for example, for robotaxis). All of these will cost money and require capitalism in order to operate. And before anyone says "the government will provide everything" planned / government run economies don't work and history shows that, and if everything was run by the government that would basically stifle innovation and destroy the middle and upper classes.

In short, capitalism just ain't going anywhere, despite what some may want to believe.

submitted by /u/Phoenix5869
[link] [comments]
Using the Atacama Large Millimeter/submillimeter Array (ALMA), of which ESO is a partner, astronomers have discovered a large reservoir of hot gas in the still-forming galaxy cluster around the Spiderweb galaxy—the most distant detection of such hot gas yet. Galaxy clusters are some of the largest objects known in the universe and this result, published today in Nature, further reveals just how early these structures begin to form.
Huge Group Calls for Temporary Pause on AI More Advanced Than GPT-4
Feedly AI found 1 Regulatory Changes mention in this article
  • Last year, US president Joe Biden released a draft of an AI bill of rights, which would allow citizens to opt out of AI algorithms making decisions, but experts criticized the proposal for being toothless .
An open letter, signed by over 1,100 AI experts andCEOs, including SpaceX CEO Elon Musk, is calling for a six-month moratorium on "AI experiments."

An open letter, signed by over 1,100 artificial intelligence experts, CEOs, and researchers — including SpaceX CEO Elon Musk — is calling for a six-month moratorium on "AI experiments" that take the technology beyond a point where it's more powerful than OpenAI's recently released GPT-4 large language model.

It's a notable expression of concern by a veritable who's who of some of the most clued-in minds working in the field of AI today, including researchers from Alphabet's DeepMind and the "godfather of AI" Yoshua Bengio.

"AI systems with human-competitive intelligence can pose profound risks to society and humanity, as shown by extensive research and acknowledged by top AI labs," reads the letter, issued by the nonprofit organization Future of Life, adding that "advanced AI could represent a profound change in the history of life on Earth, and should be planned for and managed with commensurate care and resources."

"Unfortunately, this level of planning and management is not happening," the letter continues, "even though recent months have seen AI labs locked in an out-of-control race to develop and deploy ever more powerful digital minds that no one — not even their creators — can understand, predict, or reliably control."

The letter questions whether we should allow AI to flood the internet with "propaganda and untruth" and take jobs away from humans.

It also references OpenAI CEO Sam Altman's recent comments about artificial general intelligence, in which he argued that the company will use AGI to "benefit all of humanity," sentiments that were immediately slammed by experts.

The six-month pause the experts call for should be used to "develop and implement a set of shared safety protocols for advanced AI design and development that are rigorously audited and overseen by independent outside experts," they write.

"AI research and development should be refocused on making today's powerful, state-of-the-art systems more accurate, safe, interpretable, transparent, robust, aligned, trustworthy, and loyal," the letter reads.

That kind of concern is echoed by governments around the world, which are struggling to get ahead of the problem and address the regulation of AI in a meaningful way. Last year, US president Joe Biden released a draft of an AI bill of rights, which would allow citizens to opt out of AI  algorithms making decisions, but experts criticized the proposal for being toothless.

And it's not just governments. Musk, who helped found OpenAI in 2015 before leaving over ideological differences three years later, has repeatedly voiced concern over overly powerful AI.

"AI stresses me out," the billionaire told Tesla investors earlier this month, clarifying later that he's a "little worried" about it.

"We need some kind of, like, regulatory authority or something overseeing AI development," Musk added at the time. "Make sure it's operating in the public interest. It's quite dangerous technology. I fear I may have done some things to accelerate it."

With OpenAI, a company that transformed from a non-profit to a for-profit after Musk left, it's not a stretch to see the potential dangers of a profit-driven model of AI development.

Whether the company is acting in good faith or hunting multibillion-dollar deals with the likes of Microsoft to maximize profits remains as murky as ever.

And the danger of a runaway AI that does more harm than good is more prescient than one might think. The current crop of AI models, such as GPT-4, still have a worrying tendency to hallucinate facts and potentially mislead users, an aspect of the technology that clearly has experts spooked.

More on AI: Levi's Mocked for Using AI to Generate "Diverse" Denim Models

The post Huge Group Calls for Temporary Pause on AI More Advanced Than GPT-4 appeared first on Futurism.

Ornithine aminotransferase supports polyamine synthesis in pancreatic cancer

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05891-2

Pancreatic ductal adenocarcinoma cells show a specific dependency on 
ornithine aminotransferase
-mediated ornithine synthesis from glutamine, providing an opportunity to develop targeted therapies with minimal toxicity for this 
Structural basis for GSDMB pore formation and its targeting by IpaH7.8

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05832-z

The authors report the cryogenic electron microscopy structures of human 
 in complex with Shigella IpaH7.8 and the GSDMB pore, shedding light on the molecular mechanisms of Shigella IpaH7.8 recognition and targeting of GSDMs and GSDMB pore formation.
Mechanistic formulation of inorganic membranes at the air–liquid interface

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05809-y

By switching the nucleation preferences in aqueous systems of inorganic precursors to bias formation and growth at the air–liquid interface, the mechanistic formation of inorganic membranes from the floating-particle system is demonstrated.
An atlas of genetic scores to predict multi-omic traits
Is this article about Neuroscience?

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05844-9

A machine learning approach is used to analyse multi-omics (proteomics, metabolomics and transcriptomics) data, producing genetic scores for more than 17,000 biomolecular traits in human blood, and identifying possible associations with disease.
Programmable protein delivery with a bacterial contractile injection system
Is this article about Tech & Scientific Innovation?

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05870-7

The tail fibre of an extracellular contractile injection system (eCIS) from Photorhabdus asymbiotica recognizes targets expressed on eukaryotic host cells, and can be reprogrammed to target specific organisms and cell types for delivery of novel protein payloads.
Spatial multiomics map of trophoblast development in early pregnancy

Nature, Published online: 29 March 2023; doi:10.1038/s41586-023-05869-0

A multiomics single-cell atlas of the human maternal–fetal interface including the myometrium, combining spatial transcriptomics data with chromatin accessibility, provides a comprehensive analysis of cell states as placental cells infiltrate the uterus during early pregnancy.
Genome-based scores predict thousands of molecular traits in humans

Nature, Published online: 29 March 2023; doi:10.1038/d41586-023-00721-x

Genetic scores for predicting levels of several types of biomolecule have been developed and validated in people of diverse ancestries, and used to uncover insights into disease biology. An open resource to disseminate these scores, OmicsPred, will enable researchers to predict various molecular traits from genetic profiles in their own data sets.
Medieval Swahili people had both African and Asian ancestry
Is this article about Diversity & Inclusion?

Nature, Published online: 29 March 2023; doi:10.1038/d41586-023-00302-y

Analyses of ancient DNA from 80 individuals buried in medieval Swahili stone towns along the East African coast revealed that these individuals had both African and Asian ancestry. The findings suggest that in most cases, African women began having children with Asian men at least 1,000 years ago, at several locations along the coast.
Memristor devices denoised to achieve thousands of conductance levels

Nature, Published online: 29 March 2023; doi:10.1038/d41586-023-00724-8

The number of distinguishable conductance levels in memristor devices — electronic components that store information without power — has been limited by noise. An understanding of the source of the noise, and development of an effective denoising process, have now enabled 2,048 conductance levels to be achieved in memristors in large arrays fabricated in a chip factory.
Clues to the assembly of an infant galaxy cluster

Nature, Published online: 29 March 2023; doi:10.1038/d41586-023-00875-8

Galaxy clusters are among the largest objects in the Universe to be held together by their own gravity. Most of the ordinary matter in nearby galaxy clusters is associated with a diffuse, hot-gas component. The detection of this 'intracluster medium' in a distant protocluster of galaxies sheds light on the cluster's formation history.
Health benefits of growing up in cities have diminished globally
Is this article about Global Health?

Nature, Published online: 29 March 2023; doi:10.1038/d41586-023-00305-9

An unprecedented data set of the body measurements of 71 million children and adolescents reveals that, in most countries, growing up in cities no longer results in the height advantage seen in most of the world in the 1990s. However, in much of sub-Saharan Africa, the growth and development advantages of urban living have been amplified.
Piezoelectric effect in liquids observed for the first time
A pair of chemists at Michigan State University has observed the piezoelectric effect in liquids for the first time. In their paper published in The Journal of Physical Chemistry Letters, Md. Iqbal Hossain and G. J. Blanchard, describe accidently observing the property while studying ionic liquids.
Don't take batteries to the moon or Mars, 3D print them when you get there
When the Artemis astronauts and future explorers go to the moon and Mars, they'll need power. Lots of it. Of course, they'll use solar panels to generate the juice they need for habitats, experiments, rovers, and so on. But, they'll need batteries for power storage. Those things weigh a lot and cost a fortune to send up from Earth. So, why not simply 3D print their own when they get there?
Is this article about Weather?
The country of Turkey is still reeling from a 7.8 and a 7.5 magnitude earthquake and thousands of aftershocks that occurred in February, causing widespread destruction to infrastructure and human life. To aid response and recovery efforts, two researchers from the University of Alabama in Huntsville (UAH) Earth System Science Center (ESSC) are using Earth observations to help those on the ground in Turkey make informed decisions.
Next-generation aramid fiber with electrical conductivity
Is this article about Tech & Scientific Innovation?
Aramid fiber is known as "super fiber," or "golden silk," because even though its weight is equivalent to only 20% of the weight of steel, it is more than five times as strong and does not burn, even at 500°C. Aramid fiber is an essential material used in various applications such as body armor, fire-resistant clothing, fiber optic cable reinforcement, high-performance tires, and aerospace materials. The late Dr. Han-Sik Yun began researching aramid fiber at the Korea Institute of Science and Technology (KIST) in 1979 and secured independent source technology in 1984.
Magnon-based computation could signal computing paradigm shift
Like electronics or photonics, magnonics is an engineering subfield that aims to advance information technologies when it comes to speed, device architecture, and energy consumption. A magnon corresponds to the specific amount of energy required to change the magnetization of a material via a collective excitation called a spin wave.
Autism märks redan hos spädbarn – rörelser uppfattas annorlunda

Barn med autism har redan som bebisar en annorlunda aktivitet i hjärnan när de tittar på mönster och saker som rör sig. Kunskap om skillnaden kan leda till bättre förståelse av den tidiga utvecklingen vid autism.

Inlägget Autism märks redan hos spädbarn – rörelser uppfattas annorlunda dök först upp på

Researchers of Wageningen University & Research have identified a recent incursion of non-native iguanas on Saba, which form a major threat to the endemic melanistic iguana population. A promising study shows a new methodology with which non-native iguanas can be recognized and removed at an early stage for more effective protection of native populations.

Scientific Reports, Published online: 29 March 2023; doi:10.1038/s41598-023-32251-x

Retraction Note: The 
 axis promotes invasion and 
hepatocellular carcinoma
 via induction of epithelial-mesenchymal transition by targeting 
Researchers of Wageningen University & Research have identified a recent incursion of non-native iguanas on Saba, which form a major threat to the endemic melanistic iguana population. A promising study shows a new methodology with which non-native iguanas can be recognized and removed at an early stage for more effective protection of native populations.
Tree ring width predicted by machine learning
Tree rings are record books of annual growth, and the width of each ring is correlated to that year's environmental conditions. In a new study, Cameron Lee and Matthew Dannenberg use machine learning to demonstrate that ring width is well correlated with the types of air masses a tree experienced over the past year.
Examining why egg yolk was used in Old Masters' oil paints
A team of chemical engineers affiliated with several institutions in Europe has determined why Old Masters of the 16th, 17th, and early 18th centuries added egg yolk to their oil-based paints. In their study, reported in the journal Nature Communications, the group added fresh egg yolk to the types of oils used by Renaissance painters and tested them to see changes it made to their properties.
Lamborghini's Revuelto Is Its First Hybrid
Feedly AI has detected a Product Launch in this article
The 217-mph electrified Revuelto puts out 1,001 horsepower and boasts 13 driving modes, but it can manage only 8 miles on battery power alone.
An international team led by researchers from IRTA at the IBB-UAB and the University of Bergen have identified a unique set of genes that allows marine teleost fishes to hydrate their eggs so that they float and disperse for survival in the ocean. The discovered mechanisms shed new light on the evolution of this group of fishes, to which almost all modern marine fishes belong and whose ancestors ventured from freshwater to the saline domain.
Bacterial injection system delivers proteins in mice and human cells
Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals. The technology, described today in Nature, can be programmed to deliver a variety of proteins, including ones for gene editing, to different cell types. The system could potentially be a safe and efficient way to deliver gene therapies and cancer therapies.
How the ancestors of today's marine fishes conquered the oceans
An international team led by researchers from IRTA at the IBB-UAB and the University of Bergen have identified a unique set of genes that allows marine teleost fishes to hydrate their eggs so that they float and disperse for survival in the ocean. The discovered mechanisms shed new light on the evolution of this group of fishes, to which almost all modern marine fishes belong and whose ancestors ventured from freshwater to the saline domain.
The Gun
Is this article about Military?

the gun heard the first shot     the gun thought it was a bursting pipe    the
gun heard the second shot and the third      and the fourth      the gun real-
ized this was not a pipe           the gun's teacher told everyone to get on the
ground         the gun's teacher went to lock the door        the gun saw glass
break      and the teacher slump      and bleed      and fall silent      the gun
texted its parents        and said i love you        i'm so sorry for any trouble i've
caused all these years       you mean so much to me       i'm so sorry      the gun
thought it would never leave the classroom        the gun moved to a closet
filled with several other shaking guns       the gun texted its best friends in
the group chat to see if they were okay          the gun waited on a response
the gun received one     the gun did not receive another     the gun waited
for an hour    the gun heard the door kicked open    the gun was still    in
the closet   and didn't know who had entered the room   the gun thought
this was the end       the gun thought of prom and graduation and college
and children and all the things the gun would never have    the gun heard
more bullets   the gun heard he's down!   the gun climbed out of the closet
the gun put its hands on its head        the gun walked outside       the gun
saw the cameras    the gun hugged its sobbing mother   and cried into her
arms    the gun heard thoughts and prayers    the gun heard Second Amend-
    the gun heard lone wolf    the gun texted its friend again    the gun
waited for a message    the message never came

Inside the cozy but creepy world of VR sleep rooms
Is this article about Wellbeing?

Lo-fi chill music was playing in the distance. Shooting stars sliced through the sparkling galaxy overhead. I was defying physics, hovering in space, on my back. Relaxed, I yawned and stretched, my fist punching a pillow that I had forgotten about.

I was, of course, not in space. Physically, I was on a chaise in my home. Virtually, I was in one of many "sleep rooms" on the virtual-reality platform VRChat—virtual spaces where people can relax, and even sleep, with their headsets on. VR sleep rooms are becoming popular among people who suffer from insomnia or loneliness, offering cozy enclaves where strangers can safely find relaxation and company—most of the time.

Each VR sleep room is created to induce calm. Some imitate beaches and campsites with bonfires, while others re-create hotel rooms or cabins. Soundtracks vary from relaxing beats to nature sounds to absolute silence, while lighting can range from neon disco balls to pitch-black darkness. The opportunity to sleep in groups can be particularly appealing to isolated or lonely people who want to feel less alone.

That's the case for Mydia Garcia, who began social sleeping almost a year ago: "I'd go dancing [in VR] till 3 a.m., and I was tired but I didn't want to leave VR or my friends." Garcia and their friends would visit secluded worlds and then cuddle together, finding the experience therapeutic and bonding.

Likewise, Jeff Schwerd discovered sleep rooms during the pandemic and found an antidote to loneliness. He likes to snuggle with strangers and often uses full-body tracking, which allows avatars to move in sync with IRL bodies, to imitate the feeling of being cuddled and held. Schwerd says it makes him feel protected and so more able to sleep. He finds the atmosphere of sleep rooms relaxing, too.

"My favorite place to relax alone is this grassy hill with a campfire," he says. "I like hearing the sound of the fire."

The company is not the only reason people fall asleep in VR. Scott Davis uses VRChat sleep rooms multiple times a week to fight his insomnia. "It's so much easier to sleep in VR for me, and it has helped me get sleep more reliably," he says. "Normally, outside of VR, I need to be quite fatigued to fall asleep. But in VR, I can go and lie down and fall asleep faster, even if I'm not tired at first."

It's why he returns to sleep rooms. "I can feel confident that I am controlling my sleep as an insomniac," Davis says.

That feeling of control is a huge reason why VR can have a therapeutic effect for people with insomnia, says Massimiliano de Zambotti, a neuroscientist who researches sleep at the nonprofit SRI International.

"If you have insomnia, you go to bed and your brain starts spinning. You have worries and ruminations and your heart is racing. You're not relaxed and in an elevated state of arousal, which prevents you from falling asleep," de Zambotti says. "Neuroscientifically, VR works because you can modulate the environment you are in, but you have an anchor to reality and can feel safe enough to fall asleep."

The trouble is, what if the experience doesn't make you feel that way?

Feeling safe is crucial for relaxation and sleep, even if you are alone in your own bed at home. 

I entered a sleep room one day and immediately heard the voice of a child in my ear. The kid, who had a robot avatar, tried and failed to engage me and a medieval knight in conversation. (My avatar was a stick of butter with a tiny top hat, because why not?) Exasperated, the robot floated over to the corner where about seven avatars were peacefully lying together, seemingly asleep. The child's voice then taunted them: "I will kill you. I will literally kill you."

It's well known that the metaverse is full of underage users, and my journey through sleep rooms confirmed that kids pop up disturbingly often in these adult spaces. Another sleep room I visited was overrun with childlike voices speaking Spanish and French. I took an elevator up to a "roof" where I found a corner illuminated in red lights with plush, velvety couches. "Hi, I like your avi [avatar]," a kid's voice said behind me. I swiveled around to find another robot avatar talking to what appeared to be a scarecrow. "I like yours too," a man's voice said. "Wanna cuddle?" The child floated away and I followed suit, unnerved.

Schwerd told me that he'd seen kids in sleep rooms, too. "You definitely get underage people being a nuisance," he says. But he insisted that most sleep rooms were quiet and "respectful." 

As I roamed around, I mostly found this to be true. Some sleep rooms I stumbled into were empty and silent. Others had avatars nestled against each other, fast asleep. Still others had groups of avatars huddled together, awake but quiet, some whispering, others just relaxing. I often felt the need to mutter "Excuse me" and tiptoe, forgetting that since I was a drifting stick of butter in a room full of avatars, few would hear me or care.

I couldn't fall asleep in VR. I was extremely aware of my surroundings and found the headset on my face uncomfortable. But while I found some rooms to be disturbing, I did discover sleep rooms that were hushed and peaceful, places to simply sit and be. In the real world, I struggle to find quiet places to relax in, and if nothing else, virtual sleep rooms offered me space and time to lie back and stare at the stars.

As temps rise, preschoolers get less exercise outside
preschooler exercises outside, drinks water while sweaty

As the weather gets hotter, preschoolers get less exercise outside, research finds.

The findings, published last week in the Journal of the American Medical Association Pediatrics, may seem obvious to anyone who's watched their little ones wilt and turn red-faced on the playground. But researchers approached the question in a novel way: they used advanced wearable activity monitors to follow specific children in a specially designed laboratory school for studying child behavior and development.

"Given that we're seeing an increasing number of hot days," says Andrew Koepp, lead author of the paper and PhD candidate in human development and family sciences at the University of Texas at Austin, "it's important to understand how young children's activity changes so that we can take steps to make sure they are getting the physical activity they need to be healthy."

The study looked at children ages three to six who are enrolled at the Priscilla Pond Flawn Child and Family Laboratory School on campus. The study used digital wearable activity monitors on each child for a week in April 2022 as the children played on the school's partially shaded playground. Ambient air temperatures were between 72 degrees and 95 degrees Fahrenheit.

When temperatures were at 72 degrees, children engaged in moderate to vigorous physical activity (MVPA) for 27% of their outdoor play time. MVPA is defined as raising the heart rate to the point where a person can speak, but would have a hard time singing. When temperatures rose to 95 degrees, MVPA dropped to 21% of outdoor play time. Additionally, sedentary time, where children were sitting or still, rose on hotter days from 62% on play time at 72 degrees to 70% of playtime at 95 degrees.

The Centers for Disease Control recommends that children between the ages of three and five be physically active throughout the day, as physical activity improves young children's development, academic performance and learning, and helps build strong muscles and bones, contributes to healthy weight and blood sugar levels, and improves cardiovascular, lung, and mental health.

The sample at the laboratory school is made up of healthy, middle- and upper-income children, but, as laboratory school director Amy Bryan, an associate professor of practice in human development and family sciences, explains: "These effects would likely be amplified in more vulnerable children who had health issues or other risk factors for low activity, as would the impacts on their development."

Indoor play is not a reasonable substitute for outdoor play, says coauthor Liz Gershoff, a professor of human development and family sciences.

"Other research by our team has shown that children are much more physically active outside than inside," Gershoff notes. "This is likely in large part because classrooms have more expectations about behavior indoors than outdoors. There may be some indoor and air-conditioned settings that are conducive to physical activity, such as indoor gyms and play places, but those may not be available in all areas."

Because young children may be less aware of things such as the need to slow down and drink water, heat can be especially dangerous for them. Adults monitor children for signs of distress and take steps to keep kids safe.

Playgrounds may also have to change, Koepp says, by adding more features like shade sails, heat reducing materials, fans, misters, and water play areas. Play times may also have to move to earlier in the morning when it's cooler.

"A lot of policies are focused on stopping climate change, but in many ways, it's already here," says Koepp. "We need to start looking at policies, practices, and recommendations that recognize that, if we're going to limit the impacts on the next generation."

Coauthors are from the University of Texas Health Science Center. Houston School of Public Health Austin Campus also contributed to the research. The research had funding from the National Science Foundation, the National Academy of Education/Spencer Foundation, the Graduate School of The University of Texas at Austin, and the Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Source: UT Austin

The post As temps rise, preschoolers get less exercise outside appeared first on Futurity.

Bacterial injection system delivers proteins in mice and human cells
Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have harnessed a natural bacterial system to develop a new protein delivery approach that works in human cells and animals. The technology, described today in Nature, can be programmed to deliver a variety of proteins, including ones for gene editing, to different cell types. The system could potentially be a safe and efficient way to deliver gene therapies and cancer therapies.
Scientists solve mystery of cubic ice
Scientists from the Institute of Physics of the Chinese Academy of Sciences (CAS) have made a major breakthrough in the study of ice by confirming the formation of pure-phase cubic ice at low-temperature interfaces.
New paper investigates exoplanet climates
Inspired by the Milankovitch cycles that play a role in Earth's climate over time, new research at Florida Tech examines how these recurring orbital movements may affect the climate of exoplanets.
That Startup Run by ChatGPT Doesn't Seem to Be Doing So Great
Is this article about ESG?
A guy says he's growing a startup through ChatGPT's wisdom alone. But the company's website is seriously off — concerning, as he's accepting cash donations.

That startup being run by 


 is still going — but from the outside, it looks like kind of a mess.

To recap: about two weeks ago, self-described "AI soothsayer" Jackson Greathouse Fall took to Twitter to announce that he would be commencing what he described as the #HustleGPT challenge. Basically, Fall would ask ChatGPT to start a business, with only $100 to start. He'd get directions from ChatGPT on how to grow and scale the business, and act as the bot's "human liaison," to follow its bidding.

The project went viral, with AI bros calling it a "god mode" use of ChatGPT, and at first Fall was posting regular updates that gave a sense of momentum. But at this point, he hasn't posted a new update since last Wednesday — so we're starting to wonder what's going on with the project.

For one thing, even when he was still posting updates, progress was sounding iffy. His last update last week, for instance, claimed that the company — a sustainable e-commerce website called Green Gadget Guru that ChatGPT directed him to set up — had generated $130 in revenue. Sure, that would be something, but assuming that Fall was working eight-hour days on the project, it still means that as of that update, he'd been making less than $3 per hour. At that rate, it'd be a long road toward making good for his investors, who he said had contributed around $7,700, nevermind turning a profit.

In theory, a site like Green Gadget Guru could be roaring along by now. ChatGPT basically told Fall to spin Green Gadget Guru up as an affiliate marketing site, meaning it would recommend products and get a small kickback if anyone bought them. That's an extremely well-established niche, and all the tech exists to quickly fire up a new affiliate operation.

At first, it did sound like Fall was making concrete progress. He announced last week that he — sorry, ChatGPT — had hired two humans to help with the business: a content writer tasked with using ChatGPT to generate blog posts for the company website and a graphic designer who would use the text-to-image generator Midjourney to create the site's imagery.

Judging by the status of the Green Gadget Guru site, though, ChatGPT seems to be struggling severely. Frankly, it's a bit wretched. Seriously. Check it out yourself.

For one thing, despite Fall's talk of that human writer producing copy for the site, the only blog posts it's published so far — like this one, "Ten Eco Friendly Kitchen Gadgets" — contain only the "lorem ipsum" text that designers use to test a layout before it has any content. If you think about it, it's also a little strange that ChatGPT told Fall to hire a human writer at all. Why can't ChatGPT write the blogs and copy itself?

Another glaring issue is that there don't seem to be any actual products on the site. There are technically product categories, but for some reason all of them — Electronics, Home & Garden, Office Supplies, Personal Care, and Kitchen — are represented by the same picture of a green t-shirt. But nothing seems to happen when you click on them.

There is a "featured product," which the site lists with the amazingly generic title of "eco-friendly water bottle," but the so-called water bottle is similarly represented by a picture of a green tote bag, and there doesn't seem to be any way to actually buy it. ("It" being either the water bottle or the tote bag.)

Particularly weird is what we can't find on the site: a single affiliate link to any actual product. And that raises a further question: without them, how did the site generate that piddling $130 in revenue that Fall was talking about last week?

Fall didn't address that question when we asked, but he did write us a brief message addressing the status of Green Gadget Guru.

"AI directed website moving at human speed," he said. "Promise y'all will have more updates soon, I know everyone's waiting on the edge of their seats."

He also pointed us to a tweet in which he seemed to acknowledge that progress had been slow.

"I gotta be real with y'all, last week kicked my ass," it read. "I'm still learning how to context-shift multiple times a day and get all my work done."

"More GGG + HustleGPT progress threads tomorrow!!!" he added (no new thread appeared the next day.)

Other netizens, we should note, have their own misgivings about the ChatGPT-run Green Gadget Guru.

"The unfortunate reality is that HustleGPT kinda started as a grift. The guy didn't even fix up the website he took like $7,500 in investments for," tweeted Dave Craige, a #HustleGPT enthusiast and Green Gadget Guru pessimist. "We can turn that around! We can push for a radically better approach to ethics / money. We can do things completely different."

"Where did the revenue come from?" asked another netizen, in response to Fall's final thread about the project last week, wondering like we did: "how did the $130 in revenue come about??"

Are you involved with HustleGPT or the AI startup scene? Reach out:

Of course, starting up a company that actually makes money — especially with only $100 in startup costs — is hard. And it's difficult to believe that very many investors thought that a company run by an experimental chatbot was going to be a watertight financial decision. It's easy to imagine that for most of them, it was like buying a bit of Dogecoin just for the laughs.

Still, the virality of Fall's thread compared to the dubious results does illustrate the reality-clouding hype that's sweeping the AI space right now. In fact, it can kinda reek of web3-like grifting — a type of digital scammery made possible by the frothy, unbridled, and often unfounded hype around a new piece of gold rush tech. (Fall, according to his LinkedIn, was the cofounder of a blockchain company back when that market was red hot.)

It's worth mentioning that AI bros have already been pumping up Fall's work, celebrating the Green Gadget Guru's supposed $130 in revenue and calling it one of the "most incredible things" that's been done with GPT-4 — without addressing any of its glaring and obvious issues. If that's not the hype cycle in action, we don't know what it is.

That said, though, it's probably most likely that Fall just didn't expect his tweet to take off, and now has the unenviable job of watching ChatGPT try to run a company, a task that it doesn't seem quite ready for just yet.

The reality, of course, is that AI tech still has a lot of rough edges, and its business applications are consequentially still hazy. Its work often looks good on the surface, but there are frequently deep issues under the hood that still need to be worked out.

And honestly, who knows. Maybe Green Gadget Guru will become a runaway success with ChatGPT calling the shots. Maybe the chatbot, and Fall doing its bidding, just need a little more time to get it off the ground. We'll be watching.

In the meantime, if you have any questions, you can email Green Gadget Guru at its email address, which is currently listed as Best of luck.

More on HustleGPT: Man Starts Business with Only $100 by Doing What ChatGPT Tells Him

The post That Startup Run by ChatGPT Doesn't Seem to Be Doing So Great appeared first on Futurism.

Amazing Video Shows Avalanche Coming Straight Toward Cameraperson
Is this article about Weather?
An amazing video recorded by Thoams Farley shows a couple of skiers watching as a giant avalanche thunders through a snowy mountain valley.

Powder Cloud

An amazing video recorded by Thomas Farley, who was visiting a Utah ski resort earlier this week, shows a couple of skiers watching as a giant avalanche thunders through a snowy mountain valley — and then eventually inundates them, in a much-diminished form — in a powerful demonstration of the forces of nature at work.

"What the heck, bro," Farley exclaimed, watching the giant cloud approach at blistering speeds. "Here it comes, bro."

The video, which was taken on the outer edge of the Sundance Mountain Resort in Utah on Monday, cuts off just in time for the gigantic cloud of snow to engulf the incredulous group of skiers.


Off Property

Fortunately, despite the daunting end to the video, nobody appears to have gotten hurt.

"I checked to make sure I was not going to get hit and then got my phone out to film," Farley told Storyful. "The avalanche did not make it to the resort boundaries, but the massive powder cloud did. [It] kept us covered in a super thick cloud of snow for one or two minutes."

The resort's Twitter account later confirmed that the avalanche "happened off resort property and no one was hurt. We are very grateful for our amazing ski patrol and mountain operations crew who work tirelessly to make sure our slopes are safe."

"We remained open all day and hope you will join us tomorrow for more amazing skiing and boarding," the resort added in a follow-up.