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Nyheder2022juli09

Synthetic phosphoethanolamine-modified oligosaccharides reveal the importance of glycan length and substitution in biofilm-inspired assemblies
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31633-5 The phosphoethanolamine modified cellulose in E. colibiofilms has revealed that polysaccharide functionalization alters the biofilm properties. Here, the authors show a model system to explore the role of phosphoethanolamine and other unnatural modifications on the properties of the biofilm-inspired assemblies.
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LATEST

Autonomous Vehicle Attacked by Furious Pedestrian
Way to Go People in Tempe, Arizona apparently really hate Waymo's autonomous, self-driving vehicles — so much so that a pedestrian attacked a vehicle with at least one passenger inside earlier this week. A pedestrian ran out in front of the vehicle in the early morning hours on Tuesday while it was in self-driving mode, the Verge reported on Thursday . Waymo spokesperson Nick Smith told the pub t
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Get the Party Going This Summer with These Essentials
Summer is a time to relax, but if you're set on hosting shindigs for your friends and family, it can become a tad stressful. If you need some summer entertaining help, we've compiled a list of some of the best summer entertaining products, from sound systems and ice holders to drink additions and flatware. Whether you're looking for something small and simple, like an ice tray, to something grand
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Scientists Quantum Entangle Two Atoms Over 20 Miles Apart
Quantum computing just got one step closer. Well, actually just about 20 miles closer, but the point stands. A group of researchers in Germany published a new study earlier this week in the journal Nature . The team described how they broke the distance record for entangling two atoms that were 20.5 miles apart, meaning that one of the biggest requirements for quantum computing and safe data tran
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Long Covid: what we know about it and how best to treat it
Symptoms can persist for weeks but work on causes and treatments is still developing. Here's what we know so far Much has been written about long Covid. Sufferers describe troubling ongoing symptoms on social media that persist for weeks after infection. Meanwhile, research to find a cause continues and multiple theories have emerged. So what do we now know about long Covid, the risk of getting i
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Pregnant Woman Fights Traffic Ticket, Claiming Unborn Fetus Count as Passenger After Roe Reversal
Ridin' Solo A pregnant woman driving in Texas received a traffic ticket this week because officers claimed she was improperly using the HOV lane, which is designated for cars with more than one passenger. The woman is pregnant, and fighting her ticket because she says her unborn child counts as a passenger. "An officer peeked in and asked, 'Is there anybody else in the car?'" the woman told The D
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Smart Pet Door Uses Facial Recognition to Keep Strange Animals Out
Open Says Me A smart pet door that claims to recognize your pets — and only your pets — just closed its Kickstarter campaign and is headed to production. Most pet doors are basically just small holes cut into the bottom of a regular door with a plastic flap covering. The problem is that flap offers equal opportunity for wildlife, stray animals and other people's pets t o wander in your home and c
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When it comes to banter, men are in their element. But that is no foundation for lasting friendship
How lack of intimacy – and effort – can undermine male friendships Men have a friendship problem. You probably know this already, if only anecdotally – walk into any pub in the land and count the number of blokes sitting there drinking alone. Social scientists know this evidentially. Recent research by the mental health charity Movember , for example, suggests that one in three men have no close
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Programmable CRISPR-Cas9 microneedle patch for long-term capture and real-time monitoring of universal cell-free DNA
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31740-3 Real-time sensing of biomarkers via the use of wearable devices is a major aim of personalised medicine. Here, authors demonstrate an on-line wearable microneedle patch for real-time capture and monitoring of universal cell-free DNA.
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Best Android VPNs for 2022
Finding the best Android VPN can be tough when every service out there claims to be the most secure, the most private, and the fastest. We looked past the marketing claims to find out exactly which VPN providers will give you the best experience for your Android device. Like the service does for your computer at home or work, running a VPN on your Android hides your IP address, routing your traff
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Britain's electric dreams will never come true while China has a materials advantage | John Naughton
Rare earth elements hold the key to a carbon-free future, but a new report reveals the UK's shortcomings and vulnerabilities In his book Electrify: An Optimist's Playbook for Our Clean Energy Future , Saul Griffith, an American inventor, entrepreneur and engineer, sets out a plan for decarbonising the US: electrify everything. From now on, every time people replace a vehicle or renovate a buildin
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Freddy QUADRUPLES a Mine's Gold Haul! | Gold Rush: Freddy Dodge's Mine Rescue
Stream Gold Rush: Freddy Dodge's Mine Rescue on discovery+ ▶︎ https://www.discoveryplus.com/show/gold-rush-freddy-dodges-mine-rescue #GoldRush #discovery #MineRescue Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on
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Weekend reads: Retracted papers that keep getting cited; ivermectin retractions; publishing peer reviews
Would you consider a donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured: Japanese university recommends five retractions after investigating botany researcher 'Our deepest apology': Journal retracts 30 likely paper mill articles after investigation published by Retraction Watch Our list of retracted or withdrawn COVID-19 papers is up to
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Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31625-5 Understanding how our genes interact with the environment is critical to improving health. Using a large-scale discovery pipeline, here the authors investigate synergies between genetic variants and a broad range of environmental factors impacting cardiometabolic health.
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This Week's Awesome Tech Stories From Around the Web (Through July 9)
SPACE Rocket Lab Offers Next-Day Shipping to Space Devin Coldewey | TechCrunch "It wasn't long ago that orbital launches were something that took years of planning and months of tests and careful preparation. But Rocket Lab's new program will enable customers to show up at the launch site with their payload in the boot and have it in orbit 24 hours later. Premium next-day rates will apply, of cou
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Covid: one in 10 in England told to work despite signs of infection
A TUC survey has revealed that employees who may have the virus have been ordered into the workplace by bosses Nearly one in 10 workers with Covid symptoms are being pressured by managers to come into work, the Trade Union Congress (TUC) has claimed, as a new wave of coronavirus infections and hospitalisations sweeps across the country. Polling by the TUC reveals that 9% of employees displaying s
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Precision digital mapping of endogenous and induced genomic DNA breaks by INDUCE-seq
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31702-9 Understanding how DNA double strand breaks (DSBs) form and are repaired in the genome depends on their accurate measurement. Here the authors describe INDUCE-seq; a DSB-detection method that simultaneously measures physiological and induced breaks throughout the genome.
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Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31731-4 Compulsive alcohol drinking is a core feature of alcohol use disorder. Here the authors find that in rodents, neural signals in a key decision-making brain region (dmPFC) shift from behavioral control to alcohol seeking during compulsive alcohol drinking behaviour.
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Chromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31738-x Here the authors used single-molecule imaging and manipulation to study the mechanical effects of transcription factor Sox2 co-condensation with DNA and chromatin. They found that Sox2 condensates exert a high level of mechanical stress on DNA, but this stress is dramatically attenuated by nucleosomes assembled
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Make Birth Free
Immediately after the Supreme Court's decision in Dobbs came down, anti-abortion groups began distributing press releases celebrating their victory and vowing to get around to something the movement has politically neglected for the past several decades: helping mothers afford children . For so many millions already distraught by the ruling, the ready promises of help on the way came not so much
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In Praise of Pointless Goals
In July of last year, a grown man pulled on a giant bear costume and set out to walk across the country. Under the alias Bearsun , Jessy Larios, then 33, ambled from Los Angeles to New York, sweating and chafing and viewing the world through a mesh peephole. Larios told me that it was "kind of like carrying around your own prison," and that despite the costume's whimsical exterior, the interior e
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ADAMTS18+ villus tip telocytes maintain a polarized VEGFA signaling domain and fenestrations in nutrient-absorbing intestinal blood vessels
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31571-2 The molecular mechanisms ensuring the specialized structure of small intestinal villus tip blood vessels are incompletely understood. Here the authors show that ADAMTS18+ telocytes maintain a "just-right" level and location of VEGFA signaling on intestinal villus blood vessels, thereby ensuring the presence of e
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A Nodal enhanced micropeptide NEMEP regulates glucose uptake during mesendoderm differentiation of embryonic stem cells
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31762-x Fu et al. identify the highly conserved, transmembrane micropeptide, NEMEP, as a direct target of Nodal signaling, essential for mesendoderm differentiation. NEMEP interacts with the glucose transporters GLUT1/GLUT3 and promotes glucose uptake.
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Mechanism of fertilization-induced auxin synthesis in the endosperm for seed and fruit development
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31656-y In flowering plants, fertilization triggers auxin synthesis in the endosperm to promote seed and fruit development. Here the authors show that an MADS-box transcription factor AGL62 is required to activate auxin synthesis in the endosperms of Fragaria vesca, a diploid strawberry, and Arabidopsis.
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Interchromosomal interaction of homologous Stat92E alleles regulates transcriptional switch during stem-cell differentiation
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31737-y Asymmetric inheritance of organelles, proteins and RNAs occurs during stem cell division. Here the authors show the strength of pairing of homologous Stat92E loci, a stem cell-specific gene, changes immediately after the asymmetric division due to asymmetric inheritance of new histones to one of the daughter cel
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Photonic-circuited resonance fluorescence of single molecules with an ultrastable lifetime-limited transition
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31603-x Single molecules can generate high-quality single photons for quantum technologies, but coupling to waveguides is difficult. Here, the authors show on-chip background-free resonance fluorescence generation and routing from single molecules with lifetime-limited transition and waveguide-aligned dipoles.
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Clinical characteristics and immune profile alterations in vaccinated individuals with breakthrough Delta SARS-CoV-2 infections
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31693-7 SARS-CoV-2 breakthrough infections in vaccinated individuals are a public health concern. Here, the authors analyse the clinical characteristics and profile immune alterations among vaccinated and non-vaccinated residents with Delta SARS-CoV-2 infection in Guangzhou.
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Low-dimensional assemblies of metal-organic framework particles and mutually coordinated anisotropy
Nature Communications, Published online: 09 July 2022; doi:10.1038/s41467-022-31651-3 Colloidal self-assembly is a powerful strategy for designing materials, and MOFs offer wide structural and functional diversity. Here, authors present the self-assembly of MOF microcrystals using depletion interactions to form low-dimensional MOF colloidal superstructures with anisotropic properties.
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Can you increase fluid intelligence?
I want to know because I want to make a huge scientific discovery or figure out something ingenious that might benefit myself. I know being intelligent is the best way to get their, but how do I increase fluid intelligence? submitted by /u/Icy_Blacksmith6028 [link] [comments]
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XML Sitemaps インストール方法と使い方を解説
XML Sitemaps はGoogle 、 Bing 向けのXMLサイトマップを自動生成できるWordPressプラグインです 。 検索エンジン向けのXMLサイトマップを自動生成して、XMLサイトマップを通知してブログの更新情報を検索エンジンに円滑に伝えることができます。 XML Sitemaps は検索エンジンに対してXMLサイトマップを生成して通知する機能のみです。インデックス登録の状況や詳細レポートを見たい場合は、Google Search Consoleに登録する必要があります。 XML Sitemaps の概要 まず、XML Sitemapsについて説明します。 XML Sitemaps が優れていること WordPressの記事データからXMLサイトマップを生成して「Google」および「Bing」の検索エンジンに対して通知できる。 検索エンジンに対して「XMLサイトマップ
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How society thinks about risk
From pandemics to nuclear energy — the world is full of risks. Psychologists have developed a new method of determining how risk is perceived within a society.
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Whole exome sequencing predicts whether patients respond to cancer immunotherapy
Immunotherapies, such as immune checkpoint inhibitors, have transformed the treatment of advanced stage cancers. Unlike chemotherapies that kill cancer cells, these drugs help the body's immune system to find and destroy cancer cells themselves. Unfortunately, only a subset of patients responds long-term to immune checkpoint inhibitors — and these treatments can come at a high cost and with side
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Electric vehicles pass the remote road test
A new study, which demonstrates that even the most rural areas of Australia are feasible for electric vehicles, provides new hope for how the technology could be spread around the most secluded locations in other parts of the world. The study found the vast majority of residents, or 93 per cent, could travel to essential services with even the lower-range of electric vehicles currently available o
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Narwhals show physiological disruption in response to seismic survey ship noise
The reaction of narwhals to the loud noise from seismic air guns used in oil exploration involves a disruption of the normal physiological response to intense exercise as the animals try to escape the noise. The overall effect is a large increase in the energetic cost of diving while a paradoxically reduced heart rate alters the circulation of blood and oxygen.
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Elon Musk Officially Giving Up on Buying Twitter
Giving Up Tesla CEO Elon Musk is officially trying to back out of his bid to buy Twitter for $44 billion , the BBC reports . That means he will either have to pay a $1 billion fine, as stipulated in the agreement — or take Twitter to court. In fact, Twitter is ready to do just that. "The Twitter Board is committed to closing the transaction on the price and terms agreed upon with Mr. Musk and pla
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exercises to wake up a numb brain
What are good exercises or books you would recommend to wake up a numb brain? I know some may be tempted to say "any book" but I am looking for something maybe more specific. With "numb brain" I mean a person that: * has stopped training the brain and * has trouble remembering stuff * or being enthusiastic about anything related to thinking * and maybe doesn't read anymore, * or solve riddles or
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Asteroid's Surface Like a "Plastic Ball Pit," Scientists Find
Big Surprise NASA's OSIRIS-REx spacecraft's original mission was to fly to the asteroid Bennu, where it was mean to briefly land on the body's presumably rocky surface, collect a small sample, and head back home. But while most of the mission miraculously went as planned — there was one major surprise along the way. When OSIRIS-REx tried to touch down on Bennu back in 2020, it astonishingly sank
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Horrifying Loan Scheme Allows People to Buy NFTs in Installments
The Humanity Cryptocurrency loans company Teller Finance is literally applying the logic of layaway to non-fungible tokens — because, apparently, the crypto community can sink even lower . As Decrypt reports , Teller Finance is launching its aptly-named "Ape Now, Pay Later" program — yes, we're cringing just as hard as you at that tagline — to allow users to give each other loans to buy NFTs on t
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America Endures
This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here . This is my last day writing The Atlantic Daily (for now!), and I'd like to thank you all for reading. I know it's something of an ask to allow the same fellow into your inbox every evening to opine ab
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Next-generation data centers within reach thanks to new energy-efficient switches
Data centers—dedicated spaces for storing, processing and disseminating data—enable everything from cloud computing to video streaming. In the process, they consume a large amount of energy transferring data back and forth inside the center. With demand for data growing exponentially, there is increasing pressure for data centers to become more energy efficient.
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Here's What to Expect From James Webb's First Images
Sneak Peek NASA just teased us with a list of the cosmic wonders captured by the James Webb telescope for its upcoming first images. And the images are bound to be a doozy, with the space agency claiming that the images will "reveal unprecedented and detailed views of the universe." Considering that scientists working on the project were literally moved to tears from what they saw, we're inclined
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Astronomers Haven't Been This Giddy in Years
About six months have elapsed since the most powerful space telescope in history bid farewell to Earth and took off into the darkness . In that time, the James Webb Space Telescope has deployed its gold-coated mirrors, turned on its instruments, and gotten the hang of operating 1 million miles from Earth. It has taken a good look around , and it's almost ready to show us what it has found: NASA i
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Man Loses Down Payment for House When Crypto Exchange Goes Bankrupt
That's Bad Crypto broker Voyager Digital is the latest Web3 titan to fall in the wake of an industry-wide crypto crash — and the ship isn't going down without its crew and passengers. The company has filed for bankruptcy — and most customers likely won't be getting their money back, either, Bloomberg reports . Take Telvin Hodo, for instance, a 29-year-old teacher who used Voyager to invest roughl
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Feds Reportedly Investigating Driverless Taxis After They Wreak Havoc in San Francisco
Crash Course The federal government is reportedly investigating self-driving taxi company Cruise after its second reported collision, which took place just after the company was granted a permit to begin charging for driverless rides. As Reuters reports , the National Highway Traffic Safety Administration (NHTSA) is investigating General Motors' Cruise driverless vehicle division following a June
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'CubeSats are not toys.' Tiny satellites' scientific output can pack a big punch
Orbiting several hundred kilometers above the planet are two satellites, each the size of a half-loaf of bread, measuring bursts of light-speed electrons that sometimes rain into the atmosphere. When researchers first launched them in 2015, they had hoped the little satellites would last 3 months before they malfunctioned. More than 7 years later, they are still transmitting information about the
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Metamorphic diamond from the northeastern margin of Gondwana: Paradigm shifting implications for one of Earth's largest orogens
Abstract We describe the first occurrence of diamond-facies ultrahigh pressure metamorphism along the Gondwana-Pacific margin of the Terra Australis Orogen. Metamorphic garnet grains from Ordovician metasediments along the Clarke River Fault in northeastern Queensland contain inclusions of diamond and quartz after coesite, as well as exsolution lamellae of rutile, apatite, amphibole, and silica.
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Metal-carbide eutectics with multiprincipal elements make superrefractory alloys
Abstract Materials with excellent high-temperature strength are now sought for applications in hypersonics, fusion reactors, and aerospace technologies. Conventional alloys and eutectic multiprincipal-element alloys (MPEAs) exhibit insufficient strengths at high temperatures due to low melting points and microstructural instabilities. Here, we report a strategy to achieve exceptional high-tempera
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Progerin modulates the IGF-1R/Akt signaling involved in aging
Abstract Progerin, a product of LMNA mutation, leads to multiple nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disorder. Progerin also accumulates during physiological aging. Here, we demonstrate that impaired insulin-like growth factor 1 receptor (IGF-1R)/Akt signaling pathway results in severe growth retardation and premature a
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Direct and indirect impacts of urbanization on vegetation growth across the world's cities
Abstract Urban environments, regarded as "harbingers" of future global change, may exert positive or negative impacts on urban vegetation growth. Because of limited ground-based experiments, the responses of vegetation to urbanization and its associated controlling factors at the global scale remain poorly understood. Here, we use satellite observations from 2001 to 2018 to quantify direct and in
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ECM-mimetic immunomodulatory hydrogel for methicillin-resistant Staphylococcus aureus–infected chronic skin wound healing
Abstract The treatment of difficult-to-heal wounds remains a substantial clinical challenge due to deteriorative tissue microenvironment including the loss of extracellular matrix (ECM), excessive inflammation, impaired angiogenesis, and bacterial infection. Inspired by the chemical components, fibrous structure, and biological function of natural ECM, antibacterial and tissue environment–respons
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Controlling and visualizing Dirac physics in topological semimetal heterostructures
Abstract A bulk crystal of cadmium arsenide is a three-dimensional Dirac semimetal, but, in a thin film, it can behave like a three-dimensional topological insulator. This tunability provides unique opportunities to manipulate and explore a topological insulator phase. However, an obstacle to engineering such tunability is the subtlety of transport-based discriminants for topological phases. In t
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Strong mode coupling-enabled hybrid photon-plasmon laser with a microfiber-coupled nanorod
Abstract Laser based on single plasmonic nanoparticle can provide optical frequency radiation far beyond the diffraction limit and is one of the ultimate goals of nanolasers, yet it remains a challenge to be realized because of the inherently high Ohmic loss. Here, we report the direct observation of lasing in microfiber-coupled single plasmonic nanoparticles enabled by strong mode coupling. We s
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Reward ameliorates depressive-like behaviors via inhibition of the substantia innominata to the lateral habenula projection
Abstract The lateral habenula (LHb) is implicated in emotional processing, especially depression. Recent studies indicate that the basal forebrain (BF) transmits reward or aversive signals to the LHb. However, the contribution of the BF-LHb circuit to the pathophysiology of depression still needs to be determined. Here, we find that the excitatory projection to the LHb from the substantia innomin
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Deep ocean microbial communities produce more stable dissolved organic matter through the succession of rare prokaryotes
Abstract The microbial carbon pump (MCP) hypothesis suggests that successive transformation of labile dissolved organic carbon (DOC) by prokaryotes produces refractory DOC (RDOC) and contributes to the long-term stability of the deep ocean DOC reservoir. We tested the MCP by exposing surface water from a deep convective region of the ocean to epipelagic, mesopelagic, and bathypelagic prokaryotic
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Rapid adaptive radiation of Darwin's finches depends on ancestral genetic modules
Abstract Recent adaptive radiations are models for investigating mechanisms contributing to the evolution of biodiversity. An unresolved question is the relative importance of new mutations, ancestral variants, and introgressive hybridization for phenotypic evolution and speciation. Here, we address this issue using Darwin's finches and investigate the genomic architecture underlying their phenot
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On the semantic representation of risk
Abstract What are the defining features of lay people's semantic representation of risk? We contribute to mapping the semantics of risk based on word associations to provide insight into both universal and individual differences in the representation of risk. Specifically, we introduce a mini-snowball word association paradigm and use the tools of network and sentiment analysis to characterize th
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Interrogating glioma-M2 macrophage interactions identifies Gal-9/Tim-3 as a viable target against PTEN-null glioblastoma
Abstract Genomic alteration can reshape tumor microenvironment to drive tumor malignancy. However, how PTEN deficiency influences microenvironment-mediated cell-cell interactions in glioblastoma (GBM) remains unclear. Here, we show that PTEN deficiency induces a symbiotic glioma-M2 macrophage interaction to support glioma progression. Mechanistically, PTEN -deficient GBM cells secrete high levels
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HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization
Abstract HP1 proteins traverse a complex and crowded chromatin landscape to bind with low affinity but high specificity to histone H3K9 methylation (H3K9me) and form transcriptionally inactive genomic compartments called heterochromatin. Here, we visualize single-molecule dynamics of an HP1 homolog, the fission yeast Swi6, in its native chromatin environment. By tracking single Swi6 molecules, we
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FIDELITY: A quality control system for droplet microfluidics
Abstract Droplet microfluidic systems have been widely deployed to interrogate biological and chemical systems. The major limitations of these systems are the relatively high error rates from critical droplet manipulation functions. To address these limitations, we describe the development of FIDELITY (Flotation and Interdigitated electrode forces on Droplets to Enable Lasting system IntegriTY),
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Coronapod: detecting COVID variants in sewage
Nature, Published online: 08 July 2022; doi:10.1038/d41586-022-01904-8 A new study is allowing researchers to detect SARS-CoV-2 variants in wastewater, up to two weeks before conventional surveillance
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Jawbone found in Spain could be oldest European human fossil
Paleontologists believe fragment is 1.4m years old, predating previous find at same site by 200,000 years A jawbone fragment discovered in northern Spain last month could be the oldest known fossil of a human ancestor found to date in Europe, Spanish paleontologists said on Friday. The researchers said the fossil found at an archaeological site on 30 June in the Atapuerca mountain range was about
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Functioning of antibodies in autoimmune encephalitis deciphered
Using a state-of-the-art method, researchers have succeeded for the first time at unraveling the effects of autoimmune antibodies, that are directed against the brain, in detail at the atomic level. To this end, they studied two antibodies that dock to so-called GABA-A receptors in one variant of autoimmune encephalitis. Their findings on the structural mechanisms are an important step towards the
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Online art viewing can improve well-being
Viewing art while visiting galleries and museums can have powerful effects on an individual's mood, stress and well-being. But does the same hold true for viewing art in digital space? A new study investigated whether engaging with art online also has this effect. Their conclusion: a short three-minute visit to an online art or cultural exhibition also shows significant positive effects on subject
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Molecules boosting plant immunity identified
Researchers have discovered natural cellular molecules that drive critical plant immune responses. These compounds have all the hallmarks of being small messengers tailored by plants to turn on key defense-control hubs. Harnessing these insights may allow scientists and plant breeders to design molecules that make plants, including many important crop species, more resistant to disease.
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EU Warns That Current Drought Could Become "The Worst Ever" As Fires Spread
Inferno Last month, a historic heat wave ravaged Europe. Now, the continent's staring down the barrel of an ongoing drought amidst an onslaught of forest fires — and things aren't looking up. As reported by the The Associated Press , while addressing legislators on Thursday, EU commissioner Maroš Šefčovič warned that "the present drought in Europe could become the worst ever." And a drought — esp
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Brad Pitt Says He Has Prosopagnosia
Brad Pitt is one of the most recognizable faces in acting. But, as the Academy Award winning actor revealed in an interview with GQ last month, recognizing faces is something that Pitt himself seriously struggles with. While never officially diagnosed, Pitt believes he suffers from a neurological disorder known as prosopagnosia, or face blindness, a topic that started trending across the media la
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Potential energy surfaces of water mapped
Liquids are more difficult to describe than gases or crystalline solids. Researchers have now mapped the potential energy surfaces of water molecules in liquid water under ambient conditions. The work contributes to a better understanding of the chemistry of water and in aqueous solutions.
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How Charles Darwin got sexual selection wrong | Letter
The theory needs to be updated by incorporating recent genetic breakthroughs and viewing the process through a female lens, says Heather Remoff The question isn't whether or not we need a new theory of evolution ( The long read, 28 June ); it's why it has taken so long to bring the old one into the 21st century. Anchor bias, the difficulty of dislodging the first thing we learn about a topic, mak
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The Guardian view on maths and poetry: seeing the world another way | Editorial
Hours at a desk aren't necessarily the key to success – ask June Huh, the would-be poet who has won the Fields medal for mathematics June Huh, a poet manqué who says he struggles to do more than three hours' focused work a day, this week became one of the latest recipients of the highest honour in mathematics, the Fields medal . Rarely can a single sentence have contained so many apparent cultura
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Big drop for cancer screenings early in COVID pandemic
There were significant decreases in the number of screenings for breast, colorectal, and cervical cancers during the early phase of the COVID-19 pandemic, new research shows. The study in JAMA Oncology includes data included in medical journals worldwide from January 2020 into December 2021. It offers one point of evidence that the global pandemic widely affected cancer screening services. In 202
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Lesbian bars are vanishing but need for them isn't
Lesbian bars in the United States are vanishingly rare. Events that commemorate them show the value queer spaces have in communities, research shows. Back in the 1980s and 1990s, there were upwards of 200 bars that catered to lesbian, bisexual, and queer women across the United States; now, there are an estimated 21 lesbian bars left. Though the mass closures have left a void in many cities, lesb
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Research team classifies key gene for cell division for the first time
The gene KINETOCHORE NULL2 (KNL2) plays a major role in the incorporation of the histone CenH3 into the centromere of chromosomes and is thus important for cell division. This same gene is also important for the production of double haploids, with which the generation of homozygous lines for plant breeding can be accelerated quite considerably. An international research team led by the IPK Leibniz
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New study explores link between job losses and the health of young adults during the great recession
A new study published in the journal Health Economics is the first to comprehensively examine the impact of job losses during the U.S. Great Recession of 2008-09 on the mental health, physical health and the health behavior of young adults. Critically, researchers find young adults' living situation—whether they lived alone or with their parents—particularly affected whether they experienced negat
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Gestures can improve understanding in language disorders
When words fail, gestures can help to get the message across — especially for people who have a language disorder. An international research team has now shown that listeners attend the gestures of people with aphasia more often and for much longer than previously thought. This has implications for the use of gestures in speech therapy.
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Parkinson's disease: Copper leads to protein aggregation, study finds
Copper exposure in the environment and the protein alpha-synuclein in the human brain could play an important role in the pathogenesis of Parkinson's disease. Researchers were able to show how the protein takes on an unusual shape when exposed to large amounts of copper ions. The findings could help develop new strategies for the treatment of neurodegenerative diseases.
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Research team classifies key gene for cell division for the first time
The gene KINETOCHORE NULL2 (KNL2) plays a major role in the incorporation of the histone CenH3 into the centromere of chromosomes and is thus important for cell division. This same gene is also important for the production of double haploids, with which the generation of homozygous lines for plant breeding can be accelerated quite considerably. An international research team led by the IPK Leibniz
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NASA Furious at Russia's Ukraine Stunt on Space Station
Rising Tensions NASA has officially decried Russia for spreading anti-Ukraine propaganda on board the ISS earlier this week. On Monday, the Russian space agency took to Telegram to post images of ISS cosmonauts holding the flags of the Luhansk People's Republic and the Donetsk People's Republic — two separatist regions in Eastern Ukraine that only Russia and Syria recognize as independent territo
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Elon Musk Shreds Bill Gates for Supporting Hydrogen Power
Shots Fired There's nothing more Elon Musk than denouncing hydrogen power and ridiculing a billionaire foe in the same breath. Yesterday, the self-described sock aficionado and longtime hydrogen energy hater casually dismissed Microsoft founder Bill Gates' claim that hydrogen power is the " Swiss Army Knife of decarbonization " — by responding to another user's Gates-disparaging tweet with just a
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Electric vehicle buyers want rebates, not tax credits
Financial incentives play an important role in the widespread adoption of electric vehicles. New research, however, finds that not all financial incentives are created equal in the eyes of prospective car buyers, and the current federal incentive — a tax credit — is, in fact, valued the least by car buyers.
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Scientists use mini-kidney models to identify potential drugs for polycystic kidney disease
Scientists hsve generated simple kidney-like structures called organoids and used them to identify potential drugs to treat adult-onset polycystic kidney disease. To accelerate the quest for new treatments for ADPKD, researchers used pluripotent stem cells to grow organoids consisting of one or two structures resembling the kidney's filtering units, known as nephrons. To make the organoids useful
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Oceanographers develop new model to better predict barrier island retreat
Barrier islands protect the coastline from storms, storm surge, waves and flooding. They can act as a buffer between the ocean and beachfront property. As sea level rises, barrier islands retreat, or move closer toward the shore, which diminishes the buffer and protection. New information shows the retreat of coastal barrier islands will accelerate by 50 percent within a century, even if sea level
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Researchers build long, highly conductive molecular nanowire
Researchers announced today that they have built a nanowire that is 2.6 nanometers long, shows an unusual increase in conductance as the wire length increases, and has quasi-metallic properties. Its excellent conductivity holds great promise for the field of molecular electronics, enabling electronic devices to become even tinier.
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Scientists hijack bacteria to ease drug manufacturing
For more affordable, sustainable drug options than we have today, the medication we take to treat high blood pressure, pain or memory loss may one day come from engineered bacteria, cultured in a vat like yogurt. And thanks to a new bacterial tool, the process of improving drug manufacturing in bacterial cells may be coming sooner than we thought.
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Lazy Flossers Rejoice! Tiny Robot Shapeshifters Will Brush and Floss for You
If flossing is, in short, the bane of your existence, a group of researchers at the University of Pennsylvania might have an ingenious solution for you. The team has developed the ultimate no-hands dental care in the form of a swarm of shapeshifting microrobots , ready to treat and remove tooth decay-inducing bacteria and plaque from your filthy, unflossed teeth. In simple terms, the petite and m
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Genetically-enhanced biocontrols could help fight large invasive mammals
Invasive alien mammals can have catastrophic impacts on native flora and fauna, causing species extinctions and driving profound environmental change. Classical control methods such as poison baiting, trapping, or hunting are currently not feasible on a large scale, which is why researchers are looking for alternatives.
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Expanding chemical space by para-C−H arylation of arenes
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31506-x Biaryls are privileged structural motif used in the discovery and design of therapeutics with high affinity and specificity for a broad range of protein targets. Herein, the authors develop a robust strategy for para-C–H arylation of arenes with a range of (het)aryl iodides, including bioactive molecules.
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Megathrust reflectivity reveals the updip limit of the 2014 Iquique earthquake rupture
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31448-4 The rupture area of the 2014 Iquique earthquake offshore northern Chile was spatially limited to a region where the plate boundary is non-reflective in seismic images, indicative of low fluid pressure. In contrast, north and updip of the rupture area, a coherent highly reflective plate boundary indicates excess
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Soil temperature drives nitric oxide emission
Nitric oxide (NO) is a major contributor to atmospheric pollution, and forest soil is an important source of NO emission. However, there are great uncertainties in global forest soil NO emission due to lack of high-frequency NO emission measurements.
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Admit It, Squirrels Are Just Tree Rats
Ben Dantzer had spent several frustrating days trying to capture a single squirrel when the epiphany arrived. Dantzer, a rodent researcher at the University of Michigan, was standing in the Canadian Yukon, scrutinizing the uncooperative squirrel, which was perched high in a spruce tree. Then, all of a sudden, he felt as though he was looking at an optical illusion: When he viewed the squirrel one
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Machine learning predicts gut microbe communities
A new computer model predicts the communities formed by human gut microbes, report researchers. The making of the model also suggests a route toward exploring the thousands of microbe species that may be present in human digestive systems. "Whenever we increase the number of species, we get an exponential increase in the number of possible communities," says Alfred Hero, professor of electrical e
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Former Japanese Prime Minister Assassinated With "Homemade Shotgun"
Improvised Firearm Former Japanese prime minister Shinzo Abe has died after being shot with a "homemade shotgun," Bloomberg reports . It's a highly unusual event — especially considering just how rare gun violence is in Japan. The country has some of the most strict gun laws in the world, requiring potential gun owners to go through extensive background checks and paperwork, including information
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Alzheimer's disease biomarkers can predict postoperative delirium
A new study in patients reveals that two newly identified plasma biomarkers of Alzheimer's disease can predict postoperative delirium, one of the most common postoperative complications in older patients. The findings indicate the potential overlap between the mechanisms that cause Alzheimer's disease and postoperative delirium.
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This Week in Space: NASA Blasts Russia's Use of the ISS For Anti-Ukrainian Propaganda
Hello and welcome back to This Week in Space. Unlike the temperature, this week the news has some major ups and downs. Ingenuity is experiencing some wear and tear on the surface of Mars, but this week we'll hear that a team of engineers is looking to bio-inspired designs that could sidestep Mars' two greatest hazards. After a brief dropout, NASA has regained radio contact with its CAPSTONE lunar
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Optical demonstration of quantum fault-tolerant threshold
Dealing with experimental errors, which could occur in every step of quantum circuits, is of great importance, especially in the implementation of quantum computation. Generally speaking, quantum error correction requires more qubits to accomplish the correction operation.
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New approach to transcriptomics reveals properties of 35 neuron subtypes in mice
A team of researchers from University College London, Columbia University and Oxford University has developed a new approach to conducting transcriptomics and has used it to reveal the properties of 35 neuron subtypes in mice. The group has published their research in the journal Nature. Hongkui Zeng and Saskia E. J. de Vries with the Allen Institute for Brain Sciences have published a News & View
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New approach to transcriptomics reveals properties of 35 neuron subtypes in mice
A team of researchers from University College London, Columbia University and Oxford University has developed a new approach to conducting transcriptomics and has used it to reveal the properties of 35 neuron subtypes in mice. The group has published their research in the journal Nature. Hongkui Zeng and Saskia E. J. de Vries with the Allen Institute for Brain Sciences have published a News & View
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In the pursuit of scientific truth, working with adversaries can pay off
Thomas Edison and Nikola Tesla, famous inventors both, were also, famously, rivals. Their heated relationship came to a head in what became known as the "war of the currents." Tesla favored alternating currents (AC) for the United States electrical system, Edison wanted direct currents, and, though AC ultimately won out, the rivalry never faded.
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Glaciers can mean the difference between life and death for salmon during heatwaves
As climate change continues to worsen, heatwaves like one that killed hundreds of people as it rolled across the Pacific Northwest last summer have become more common and more extreme. These heatwaves can lead to mass die-offs of fish in streams that become too warm for them. However, some salmon have found a surprising savior in this battle to survive: glaciers.
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Statistical analysis of radio-flaring brown dwarf population
Brown dwarfs are known as "failed stars," owing to the lack of central hydrogen burning. They bridge the gap between planets and stars. Some brown dwarfs are found to maintain kilogauss magnetic fields and produce flaring radio emissions, similar to aurora on magnetized planets in solar system, arousing astronomers' curiosities about their field properties and dynamics.
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Glaciers can mean the difference between life and death for salmon during heatwaves
As climate change continues to worsen, heatwaves like one that killed hundreds of people as it rolled across the Pacific Northwest last summer have become more common and more extreme. These heatwaves can lead to mass die-offs of fish in streams that become too warm for them. However, some salmon have found a surprising savior in this battle to survive: glaciers.
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What Happened to Michael Flynn?
M ichael Flynn faced the camera with brow creased and lips compressed. He hadn't been born yesterday, his expression said. He was not going to fall for trick questions. "General Flynn, do you believe the violence on January 6 was justified?" Representative Liz Cheney asked him in a video teleconference deposition for the January 6 committee. Flynn's lawyer pressed the mute button and switched off
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Potential energy surfaces of water mapped for the first time
Water is certainly the best-known liquid in the world. It plays a crucial role in all biological and many chemical processes. The water molecules themselves hardly hold any secrets. In school we learn that water consists of one oxygen atom and two hydrogen atoms. We even know the typical obtuse angle that the two O-H legs form with each other. In addition, we know when water boils or freezes and h
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How to write less but say more | Jim VandeHei
As the saying goes, less is more. The same goes for words. Listen as Politico and Axios co-founder Jim VandeHei shares what he's learned leading two media companies — and how to radically rethink the way you write to keep people's attention in a distracted digital world.
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500-million-year-old fossilized brains of Stanleycaris prompt a rethink of the evolution of insects and spiders
Royal Ontario Museum revealed new research based on a cache of fossils that contains the brain and nervous system of a half-billion-year-old marine predator from the Burgess Shale called Stanleycaris. Stanleycaris belonged to an ancient, extinct offshoot of the arthropod evolutionary tree called Radiodonta, distantly related to modern insects and spiders. These findings shed light on the evolution
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500-million-year-old fossilized brains of Stanleycaris prompt a rethink of the evolution of insects and spiders
Royal Ontario Museum revealed new research based on a cache of fossils that contains the brain and nervous system of a half-billion-year-old marine predator from the Burgess Shale called Stanleycaris. Stanleycaris belonged to an ancient, extinct offshoot of the arthropod evolutionary tree called Radiodonta, distantly related to modern insects and spiders. These findings shed light on the evolution
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Brain halves 'talk' better during dreaming and running
A very fast brain rhythm helps the left brain and right brain communicate better while running—and even while dreaming—research in rodents shows. The fast rhythm linking the left and right halves of the brain has a new name: "splines," so-called because they visually resemble mechanical splines, the interlocking teeth on mechanical gears. Omar Ahmed, assistant professor of psychology at the Unive
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COVID-19 crisis increases pressure on social protection systems worldwide
Government measures against the coronavirus, in particular nationwide lockdowns, have at times suspended the mechanisms of the market economy. Through no fault of their own, many people found themselves without work or income overnight. A research team at the Max Planck Institute for Social Law and Social Policy has investigated how strongly and successfully social law has helped to secure livelih
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Positive socializing gives older adults more sense of purpose
Having positive social interactions is associated with a sense of purpose for older adults, which can fluctuate from day to day, according to new research. And although these findings apply to both working and retired adults, the research found that for better and for worse these interactions are more strongly correlated to purposefulness in people who are retired. "Specifically for our retired o
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Frequent occurrence of climate extremes in the Three Gorges region in 2021
As a key project for the governance and protection of the Yangtze River, the Three Gorges Hydropower Complex Project is the world's largest water conservancy and hydropower project, providing numerous benefits. In recent years, due to global warming, extreme climate events such as extreme precipitation, high temperatures and regional drought have occurred frequently, and these events themselves, a
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Photoinduced large polaron transport and dynamics in organic-inorganic hybrid lead halide perovskite
Organic-inorganic hybrid metal halide perovskites (MHPs) have attracted tremendous attention for optoelectronic applications. For example, cost-effective solar cells, solid-state lighting, memristors, and ultrafast spin switches in spintronics have recently been designed using MHPs. Despite the promise of the material, many questions remain regarding the nature and mobility of charge carriers in M
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Predicting the phase stability of soft matter
Soft matter is an important class of materials that typically consists of colloidal particles and/or polymers in a liquid medium. For certain compositions, these types of systems tend to (micro-)phase separate and unmix into coexisting phases that differ in composition, structure, and properties. Ph.D.-researcher Joeri Opdam developed theoretical methods to accurately predict the phase behavior of
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Understanding the calcium carbonate cycle in the North Pacific
Organic carbon and calcium carbonate are two critical components of the ocean's carbon cycle. Organic carbon originates mainly from phytoplankton photosynthesis, which is part of a complex biological pump. Calcium carbonate, meanwhile, largely derives from shell-building organisms like coccolithophores, foraminifera, and zooplankton (pteropods). Yet how or if the calcium carbonate cycle interacts
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New method for developing Pichia pastoris yeast strains with high productivity of useful proteins
A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris in order to increase its secretory production of useful proteins. Through a series of processes that involved combining gene disruptions and then serially cultivating the resulting multiple disruption strains, they develo
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New method for developing Pichia pastoris yeast strains with high productivity of useful proteins
A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris in order to increase its secretory production of useful proteins. Through a series of processes that involved combining gene disruptions and then serially cultivating the resulting multiple disruption strains, they develo
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Why can't we simply plant more trees to clean carbon dioxide from the air?
If we're to have any shot at meeting the climate targets set out in the Paris Agreement, scientists estimate that countries would need to remove billions of tons of CO2 from the atmosphere by mid-century. And that's just the start of things. We'd also have to continue removing increasing amounts every year thereafter.
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Can Sig Make Quota Before His Granddaughter's Birth? | Deadliest Catch
Stream Deadliest Catch on discovery+ ► https://www.discoveryplus.com/show/deadliest-catch #DeadliestCatch #Discovery #DiscoveryPlus Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitter.com/Disco
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Shinzo Abe Made the World Better
Updated at 12:54 p.m. ET on July 8, 2022 The Japan That Can Say No was the title of a once-famous book by a once-rising Japanese politician. Shinzo Abe, the former Japanese prime minister who was assassinated earlier today, bequeaths a much prouder legacy: a Japan that can—and does—say yes. Abe was more than the longest-serving prime minister in Japanese democratic history. Although he left offic
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There's Nothing Like a Great Takedown
There's something a little sexy about a well-executed negative review. Take Stanley Edgar Hyman's coyly lethal essay on Edmund Wilson in The Armed Vision . Hyman's first paragraphs feign modesty, dabble in flattery. His uncensored opinion gets a slow reveal—and when revealed, it's devastating. The careful dance is outlined in James Atlas's 1981 article for this publication; Atlas revels in the th
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Gene may explain forms of epilepsy with unknown cause
A new study may offer an explanation for cases of epilepsy that currently have no known cause. Epilepsy is a disorder that disrupts the normal pattern of electrical activity in the brain and often results in seizures. In many cases, the underlying cause is unknown, according to the National Institute of Neurological Disorders and Stroke. For the study in Molecular Neurobiology , the researchers s
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This AI Predicts Crime a Week in Advance—and Highlights Policing Bias
Efforts to use AI to predict crime have been fraught with controversy due to the potential to replicate existing biases in policing. But a new system powered by machine learning holds the promise of not only making better predictions but also highlighting these biases. If there's one thing that modern machine learning is good at, it's spotting patterns and making predictions. So, it's perhaps uns
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Dobbs Is No Brown v. Board of Education
Homer Plessy is being recognized more and more . In 1896, the light-skinned, French-speaking Louisianan gen de couleur was memorialized in what is considered one of the worst Supreme Court decisions in American history, Plessy v. Ferguson , which upheld Jim Crow segregation laws. The decision is second in infamy only to the Dred Scott decision, which upheld slavery and declared that Black men had
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Prospecting for interstellar oil
We have developed a new method to look for carbon compounds in space, akin to prospecting for oil on Earth. Our method is published in Monthly Notices of the Royal Astronomical Society.
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Shining a light on dark matter one particle at a time
University of Adelaide experts are trying to unlock the secrets of dark matter, which makes up 84% of the matter in the universe, but we know little about it. Researchers are using a new tool that could signal the existence of a new particle.
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Simulations show Antarctica's only insect is at risk due to global warming
A team of researchers affiliated with a host of institutions in the U.S., working with colleagues from the British Antarctic Survey, Natural Environment Research Council and the University of Johannesburg, has found evidence suggesting that warming temperatures could be putting the Antarctic midge at risk of extinction. They have published their results in the journal Functional Ecology.
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Simulations show Antarctica's only insect is at risk due to global warming
A team of researchers affiliated with a host of institutions in the U.S., working with colleagues from the British Antarctic Survey, Natural Environment Research Council and the University of Johannesburg, has found evidence suggesting that warming temperatures could be putting the Antarctic midge at risk of extinction. They have published their results in the journal Functional Ecology.
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Nanoparticle 'backpacks' restore damaged stem cells
Within a newborn's umbilical cord lie potentially life-saving stem cells that can be used to fight diseases like lymphoma and leukemia. That is why many new parents elect to store ("bank") their infant's stem cell-rich umbilical cord blood. But in the 6–15% of pregnancies affected by gestational diabetes, parents lack this option because the condition damages the stem cells and renders them useles
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New insights into the Earth's formation
Although the Earth has long been studied in detail, some fundamental questions still have to be answered. One of them concerns the formation of our planet, about whose beginnings researchers are still unclear. An international research team led by ETH Zurich and the National Center of Competence in Research PlanetS is now proposing a new answer to this question based on laboratory experiments and
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NASA mirrors on ESA pathfinder to enhance lunar navigation
NASA will supply the upcoming European Space Agency (ESA) Lunar Pathfinder satellite with an array of laser retroreflectors, mirrored devices that reflect light back at its source. The retroreflectors will validate navigation capabilities that will be critical to the Artemis missions and future lunar exploration.
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The Download: police misinformation in Minnesota, and borderless digital repression
This is today's edition of The Download , our weekday newsletter that provides a daily dose of what's going on in the world of technology. The secret police: A private security group regularly sent Minnesota police misinformation about protestors When US marshals shot and killed a 32-year-old Black man named Winston Boogie Smith Jr. in a parking garage in Minneapolis on June 3, 2021, the city was
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Paradox Basin groundwater isn't as old as previously thought
Roughly 6 million years after the Grand Canyon's formation, researchers have discovered that nearby Paradox Basin groundwater is much younger than it should have been at that depth. The methods used to reveal the basin's history could also help determine the age of other bodies of groundwater in the future, as humans continue to drill deeper wells for drinking water. The Paradox Basin, a deep dep
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Teacher bias shapes who gets special education
White students are more likely to receive special education for higher-status disabilities than are Black, Latinx, and Asian students, a new study of more than 2,000 Wisconsin public schools shows. Conversely, Black and Indigenous students are more likely to receive special education services for lower-status disabilities compared to white students. Additionally, boys are more likely to receive s
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Hidden in plain sight: Seven new species of showy tropical forest ferns
Researchers from the University of Turku have described seven new fern species from the rainforests of tropical America. Many of the species were uncovered as the byproduct of ecological research: the species diversity in tropical forests is still so poorly known that field trips and herbarium work keep discovering previously unknown species.
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Hidden in plain sight: Seven new species of showy tropical forest ferns
Researchers from the University of Turku have described seven new fern species from the rainforests of tropical America. Many of the species were uncovered as the byproduct of ecological research: the species diversity in tropical forests is still so poorly known that field trips and herbarium work keep discovering previously unknown species.
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Web archive with astronomical photographic plates goes online
Lots of little dots with no apparent pattern: Where laypeople may just see milky gray photos sprinkled with what look like random crumbs, it is enough to make astronomers' hearts miss a beat. We are talking about historical photographic plates showing negatives of the night sky. Together with the Leibniz Institute for Astrophysics Potsdam and the universities of Hamburg and Tartu (Estonia), resear
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David Biello: Are we alone in the universe?
Are we alone in the universe? This hour, we travel the cosmos with TED science curator David Biello in search of extraterrestrial life, uncovering how it may look and how we'll know we've found it. (Image credit: Elizabeth Zeeuw / TED)
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Artificial intelligence folds RNA molecules
For the function of many biomolecules, their three-dimensional structure is crucial. Researchers are therefore not only interested in the sequence of the individual building blocks of biomolecules, but also in their spatial structure. With the help of artificial intelligence (AI), bioinformaticians can already reliably predict the three-dimensional structure of a protein from its amino acid sequen
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Artificial intelligence folds RNA molecules
For the function of many biomolecules, their three-dimensional structure is crucial. Researchers are therefore not only interested in the sequence of the individual building blocks of biomolecules, but also in their spatial structure. With the help of artificial intelligence (AI), bioinformaticians can already reliably predict the three-dimensional structure of a protein from its amino acid sequen
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Scientists shed light on the emergence of pathogenic bacteria
Pathogenic bacteria are highly specialized micro-organisms that are a leading cause of human, livestock and crop disease, resulting in significant health and economic loss worldwide. How these pathogens, which sometimes even live inside the cells of their hosts, once evolved is poorly understood. An international team of researchers has now found how bacterial pathogens evolved. Their work, publis
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Scientists shed light on the emergence of pathogenic bacteria
Pathogenic bacteria are highly specialized micro-organisms that are a leading cause of human, livestock and crop disease, resulting in significant health and economic loss worldwide. How these pathogens, which sometimes even live inside the cells of their hosts, once evolved is poorly understood. An international team of researchers has now found how bacterial pathogens evolved. Their work, publis
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Wild species support half of world's population, report finds
Sustainability is key to survival of billions of people, says UN study, which notes income from wild species incentivises conservation • Patrick Vallance: 'We need to change if we're to survive' Wild plants, animals, fungi and algae support half of the world's population but their future use is threatened by overexploitation, according to a new assessment by leading scientists. From the 10,000 kn
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Optimal acceleration voltage for near-atomic resolution imaging of layer-stacked 2D polymer thin films
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31688-4 High-resolution imaging of organic 2D materials using transmission electron microscopes is challenging. Here, the authors find the optimal electron acceleration voltage, and demonstrate 1.9 Å resolution, enabling detection of interstitial defects and functional groups in 2D polymer thin films.
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The Vasectomy Influencers
This article was featured in One Story to Read Today, a newsletter in which our editors recommend a single must-read from The Atlantic , Monday through Friday. Sign up for it here. "Men, it's on us now," someone said on Twitter just hours after Roe v. Wade was overturned , on June 24. "Either start wearing contraceptives or get a vasectomy." In the two weeks since, the suggestion that men can or
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Lipolysis regulates major transcriptional programs in brown adipocytes
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31525-8 β-Adrenergic signaling is a core regulator of brown adipocyte function. Here, the authors provide unbiased insight into the transcriptional network controlled by lipolysis in brown adipocytes, showing that lipolysis is required for much of the thermogenic gene program activated by β-adrenergic signals.
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Svar på debatindlæg om ME fra Saugstad og la Cour
Vi vil gerne opfordre til, at vi på tværs af fagligheder samarbejder om at forbedre behandlingen af CFS/ME, men dette indebærer ikke, at vi må gå på kompromis med god videnskabelig og klinisk praksis, skriver forfatterne bag artikel i Ugeskrift for Læger som svar på kritik.
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Danmarks syn på ME bør smides på historiens losseplads
I en nylig artikel i Ugeskrift for Læger afviser Per Fink, professor og cheflæge for Afdelingen for funktionelle lidelser på AUH, og medskribenter de seneste retningslinjer for ME fra britiske NICE som uvidenskabelige. Det er forståeligt, for NICE har placeret Finks forældede syn på ME på historiens losseplads, skriver norsk professor og dansk praktiserende læge.
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Why Illinois' Red-Flag Laws Didn't Stop the Highland Park Shooting
Late last month, Congress passed a bipartisan gun bill with a central component that aims to expand state red-flag laws. Less than two weeks later, the limitations of that effort became plain. With better luck, Robert Crimo III, who is alleged to have killed seven people and injured dozens at a Fourth of July parade in Highland Park, Illinois, could have been a poster child for red-flag laws. Law
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The Glaring Contradiction of Republicans' Rhetoric of Freedom
F or decades Republicans have marketed themselves as the party of freedom. During the 1990s and early 2000s, conservative activists took up the description of the GOP coined by the anti-tax activist Grover Norquist as the "leave us alone" coalition, so named because it consisted of voters whose stated aspiration was to live without government interference. At the height of the coronavirus pandemi
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Democrats Try to Build Back (A Bit) Better
President Joe Biden's economic agenda might be back from the dead. If the original proposal was Build Back Better, this is more like Build Back a Bit. Democrats this week took the first formal step toward reviving a stripped-down version of the nearly $2 trillion plan that Senator Joe Manchin killed late last year. Majority Leader Chuck Schumer asked the Senate parliamentarian to review a propose
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UK Covid cases rise by nearly 20% in a week
One in 25 people in England believed to have had the disease at the end of June Covid cases have risen almost 20% in a week, with one in 25 people in England thought to have had the disease at the end of June, official figures suggest, as a leading statistician said hospitalisations from the latest surge may be "topping off". According to the latest data from the Office for National Statistics ,
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Daily briefing: Pig-to-human transplant trials inch closer
Nature, Published online: 07 July 2022; doi:10.1038/d41586-022-01882-x Clinical trials for pig-to-human organ transplants might be on the horizon. Plus, what UK Prime Minister Boris Johnson's resignation means for science and how to organize a hybrid conference.
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dia-PASEF data analysis using FragPipe and DIA-NN for deep proteomics of low sample amounts
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31492-0 The dia-PASEF technology uses ion mobility separation to reduce signal interferences and increase sensitivity of mass spectrometry-based proteomics. The authors present algorithms and a software solution, which boost proteomic depth in dia-PASEF experiments by up to 83% compared to previous work, and are specifi
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Effectiveness and protection duration of Covid-19 vaccines and previous infection against any SARS-CoV-2 infection in young adults
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31469-z Here the authors estimate effectiveness of three COVID-19 vaccines in university students and find that 2-dose mRNA vaccines offer strong protection against general SARS-CoV-2 infection caused by delta, but protection substantially declines over 6 months. While previous infection protects against reinfection, va
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Got a Well-Adjusted Cat? Scientists Would Like to Hear From You
(Photo: Zeke Tucker/Unsplash) If you're looking for an excuse to rave about Fluffy, this might be your chance. Scientists are looking for cat owners for a new study focused on feline body language. Researchers at the University of California Davis' Animal Welfare Epidemiology Lab are looking for ways to help humans build positive relationships with cats. One way they hope to do that is by studyin
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Why the party is over for Britain's Research Excellence Framework
Nature, Published online: 08 July 2022; doi:10.1038/d41586-022-01881-y Many UK universities pop the champagne when they get the results of a national research-performance review. But burnt-out academics see no cause for celebration, say Richard Watermeyer and Gemma Derrick.
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Scientists Create Programmable Nanoparticle Toothbrush
The basic design of the toothbrush hasn't changed in a thousand years — sure, there are motors, different materials, and funky shapes, but they're all still sticks with bristles attached. A team from the University of Pennsylvania believes it's time to shake things up. In a new study, the researchers have shown that shapeshifting nanoparticles can successfully clean teeth, replacing all the manua
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Energy-selective confinement of fusion-born alpha particles during internal relaxations in a tokamak plasma
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31589-6 Confining plasma for fusion requires controlling many parameters. Here the authors report the existence of a narrow parameter space for the simultaneous confinement of energetic alpha particles and removal of slowed-down helium ash in a magnetically confined fusion plasma by using kinetic-magnetohydrodynamic hyb
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Pro-inflammatory cytokines mediate the epithelial-to-mesenchymal-like transition of pediatric posterior fossa ependymoma
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31683-9 The molecular mechanisms underlying ependymoma tumorigenesis remain poorly understood. Here, single cell analysis of posterior fossa primary tumours and distal metastases highlights the role of pro-inflammatory cytokines in promoting epithelial-to-mesenchymal-transition.
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The effect of COVID certificates on vaccine uptake, health outcomes, and the economy
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31394-1 Many countries introduced COVID certificates that were required to access public venues. Here, the authors analyse data from France, Germany, and Italy, and estimate that these policies led to increased vaccine uptake of 6-13 percentage points with subsequent beneficial impacts on health and economic outcomes.
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Digital repression across borders is on the rise
Khatab Alrawhani, a Yemen-born journalist and activist, thought he could escape the persecution that journalists were experiencing in the Middle East when he left the region. But it followed him. While studying in Washington, DC, in 2015, he published posts denouncing the Houthi coup, in which an armed faction overthrew the Yemeni government. His father was briefly arrested. Soon after, his broth
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Ny robot tager slæbet på slagteriet
Slagteriarbejde har længe været blandt de mest nedslidende jobs. En ny robot udviklet af Danish Crown bruger maskinlæring til at aflaste slagteriarbejdere med de tungeste arbejdsopgaver
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Många födda i slutet av 1800-talet fick aldrig barnbarnsbarn
Vilka omständigheter påverkar ifall släktlinjer dör ut? Forskare har undersökt varför nära hälften av män och kvinnor i Skellefteåregionen födda 1885–1899 aldrig fick några barnbarnsbarn, trots en hög befolkningstillväxt under perioden. Inlägget dök först upp på forskning.se .
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Temperature elevations can induce switches to homoclinic action potentials that alter neural encoding and synchronization
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31195-6 The intrinsic dynamics of neurons, in particular the generation action potentials, can impact neural network states and processes of encoding information. The authors demonstrate how the elevation of temperature induces a type of action potential dynamics that favors synchronization patterns in neural networks.
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Cation-selective two-dimensional polyimine membranes for high-performance osmotic energy conversion
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31523-w Two-dimensional (2D) membranes are emerging candidates for osmotic energy conversion but the trade-off between ion selectivity and conductivity remains the key bottleneck. Here, the authors demonstrate a fully crystalline imine-based 2D polymer membrane capable of combining excellent ionic conductivity and high
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The contribution of common regulatory and protein-coding TYR variants to the genetic architecture of albinism
Nature Communications, Published online: 08 July 2022; doi:10.1038/s41467-022-31392-3 Albinism is a rare disorder often caused by high-effect rare variants in the TYR gene. Here, the authors study a large albinism cohort and find that a common variant in the TYR promoter contributes to albinism by modifying the penetrance of other common variants, demonstrating a complex genetic architecture.
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Narwhals show physiological disruption in response to seismic survey ship noise
The reaction of narwhals to the loud noise from seismic air guns used in oil exploration involves a disruption of the normal physiological response to intense exercise as the animals try to escape the noise. The overall effect is a large increase in the energetic cost of diving while a paradoxically reduced heart rate alters the circulation of blood and oxygen.
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Narwhals show physiological disruption in response to seismic survey ship noise
The reaction of narwhals to the loud noise from seismic air guns used in oil exploration involves a disruption of the normal physiological response to intense exercise as the animals try to escape the noise. The overall effect is a large increase in the energetic cost of diving while a paradoxically reduced heart rate alters the circulation of blood and oxygen.
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Book Review: The Limits of Drug-Based Psychiatry
"The Mind and the Moon," by journalist Daniel Bergner, is both a moving account of his brother's long struggle with bipolar disorder and a deeply reported critique of the disease model of mental illness, which he argues has not come anywhere close to living up to its grand promises.
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One deep sea mine could send noise 500km across the ocean – report
Many deep-sea species – about which very little is known – are believed to use sound to navigate and communicate, as scientists call for limits on mining Noise pollution from proposed deep-sea mining could radiate through the ocean for hundreds of kilometres, scientists predict, creating a "cylinder of sound" from the surface to the sea bed. An analysis by scientists from Oceans Initiative in the
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Photos of the Week: Oil Wrestling, Flaming Bull, Gorgosaurus Sale
A tragic shooting at a Fourth of July parade in Illinois, a fishing contest in Uruguay, a hot-dog-eating contest in Coney Island, a scary Formula 1 crash in England, scenes from the ongoing conflict in Ukraine, an anti-government rally in Albania, flooding in El Salvador, the San Fermin festival's return to Pamplona, and much more
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Building blocks for RNA-based life abound at center of our galaxy
Nitriles, a class of organic molecules with a cyano group—that is, a carbon atom bound with a triple unsaturated bond to a nitrogen atom—are typically toxic. But paradoxically, they are also a key precursor for molecules essential for life, such as ribonucleotides, composed of the nucleobases or "letters" A, U, C, and G joined to a ribose and phosphate group, which together make up RNA. Now, a tea
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Dark matter: search for the invisible begins in an old gold mine
Scientists know that it makes up most of the universe's mass, but they don't know what it is … or exactly how to find it In a former gold mine a mile underground, inside a titanium tank filled with a rare liquified gas, scientists have begun the search for what so far has been unfindable: dark matter. Scientists are pretty sure the invisible stuff makes up most of the universe's mass and say we w
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Study examines memory in expert birdwatchers
According to a new study that examined memory in expert birdwatchers, having expert knowledge in a subject helps us memorize new information. This is because, while forgetting often happens when similar memories interfere with each other, expert knowledge provides a mental organizational structure, or scaffolding, that helps us keep new items that we want to learn distinct from each other. This re
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We Finally Know Why NASA Lost Contact With Moonbound Spacecraft
All Figured Out Scientists at NASA let out a huge sigh of relief yesterday when NASA was able to successfully restore contact with its CAPSTONE satellite after it unexpectedly plunged into radio silence on Monday. And fortunately for NASA scientists, CAPSTONE " is looking happy and healthy ." Now, thanks to their tireless efforts, we finally know what caused the dropout: a bad command and a softw
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Elon Musk Rivals Snatch Up Laid-Off Tesla Employees
Gold Rush One billionaire's " super bad feeling " about the global economy is another billionaire's hiring spree. In the wake of Tesla's latest round of widespread layoffs , several big tech companies — including both Microsoft and Amazon, led respectively by vocal Tesla CEO Elon Musk nemeses Bill Gates and Jeff Bezos — are snatching up ex-Tesla employees left and right, Business Insider reports
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Contrasting behaviour under pressure reveals the reasons for pyramidalization in tris(amido)uranium(III) and tris(arylthiolate) uranium(III) molecules
Nature Communications, Published online: 07 July 2022; doi:10.1038/s41467-022-31550-7 The reasons for which many low-coordinate complexes exhibit bent geometry, rather than a higher symmetry, are still under debate. Here, the authors use high-pressure crystallography to examine whether low-coordinate f-block molecules become more planar or pyramidal under pressure; which happens is dictated by th
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