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nyheder2019august28

What Happens When You Don’t Pay a Hospital Bill

Updated at 9:10 a.m. ET on August 29, 2019. On March 8, 2011, Joclyn Krevat, an occupational therapist in New York, was sitting at her computer when she received a most unusual LinkedIn request. The wording was the familiar: “I’d like to add you to my professional network.” The sender was familiar, too, but not for the reason Krevat expected. It was from a debt collector. Karen Pollack, the head

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VGP generates largest number of high-quality genomes of iconic and endangered species

The Vertebrate Genomes Project (VGP) and collaborators are announcing the second data set of the largest number (101) of chromosomal-level genome assemblies of vertebrates towards completing Phase 1 of the VGP, which includes one representative species per vertebrate order or ~260 species. These 101 genomes, most finished or in their final stages of assembly, demonstrate the success of the VGP in

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Children who have afternoon school breaks are fitter but need a supportive environment

Afternoon breaks were once a common feature of nearly all primary school timetables. But, as schools have sought to dedicate more time to teaching and learning, and limit poor behaviour, these short play times have been cut down and, in many cases, eliminated altogether.

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Social media in a repressive society

Social media is affecting all our lives in ways we are only just beginning to recognize, whether it is the simple, but constant preoccupation many people have with sharing their digital lives or connecting with friends and family to the outpourings of politicians that are the vanguard of modern propaganda that seems to win elections. In what we might refer to as repressive societies, social media

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Isotopes in poop show where secretive jaguars hunt

How do you follow a predator so elusive that its nickname is "shadow cat"?

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Smarter experiments for faster materials discovery

A team of scientists from the U.S. Department of Energy's Brookhaven National Laboratory and Lawrence Berkeley National Laboratory designed, created, and successfully tested a new algorithm to make smarter scientific measurement decisions. The algorithm, a form of artificial intelligence (AI), can make autonomous decisions to define and perform the next step of an experiment. The team described th

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Science wages a battle against the swine sector's costliest virus

People who work in the swine sector have declared war on what is known as Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), responsible for millions in losses, not only in Spain, but throughout the world. Although it was discovered in the 90s, in recent years the sector has faced the emergence of new, more virulent strains that have, in some instances, devastated farms' entire pig popul

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Emergency medicine for our climate fever | Kelly Wanser

As we recklessly warm the planet by pumping greenhouse gases into the atmosphere, some industrial emissions also produce particles that reflect sunshine back into space, putting a check on global warming that we're only starting to understand. Climate activist Kelly Wanser asks: Can we engineer ways to harness this effect and further reduce warming? Learn more about the promises and risks of "clou

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VGP generates largest number of high-quality genomes of iconic and endangered species

The Vertebrate Genomes Project (VGP) and collaborators are announcing the second data set of the largest number (101) of chromosomal-level genome assemblies of vertebrates towards completing Phase 1 of the VGP, which includes one representative species per vertebrate order or ~260 species. These 101 genomes, most finished or in their final stages of assembly, demonstrate the success of the VGP in

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Isotopes in poop show where secretive jaguars hunt

How do you follow a predator so elusive that its nickname is "shadow cat"?

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Science wages a battle against the swine sector's costliest virus

People who work in the swine sector have declared war on what is known as Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), responsible for millions in losses, not only in Spain, but throughout the world. Although it was discovered in the 90s, in recent years the sector has faced the emergence of new, more virulent strains that have, in some instances, devastated farms' entire pig popul

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Energy-efficient solar photochemistry with luminescent solar concentrators

The sun is the most sustainable energy source available on our planet and could be used to power photochemical reactions. In the journal Angewandte Chemie, scientists present a widely applicable, cost-effective photomicroreactor. It is based on luminescent solar concentrators, which harvest, convert, and make photons available for chemical reactions. Thus, the researchers were able to synthesize v

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What if we ran society not based on the market but on evidence?

Following the successful Brexit campaign, Dominic Cummings—the then campaign director of Vote Leave—published a series of blog posts describing how the campaign was run and what his plans were for a successful civil service. The last of these posts was released on June 26 2019, just before he became the special advisor to the current prime minister, Boris Johnson. The idea this post resurrects is

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Skapandet av en bra broiler – här är rasen Plymouth Rocks släktträd

Hönsrasen White Plymouth Rock har varit central för utvecklingens av dagens moderna broilers. Men hur gick det egentligen till när denna ras avlades fram? Genomik är ett kraftfullt verktyg för att studera släktskapet mellan individer och populationer. Forskare vid Uppsala universitet, T he Livestock Conservancy och Virginia Tech i USA har i en ny studie som publiceras i den vetenskapliga tidskrif

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Eero’s routers get a cheaper $2.99 monthly subscription for added security features

Eero is adding a cheaper tier of service to its premium subscription with the introduction of the $2.99-per-month Eero Secure plan. It offers the same security, site filtering, and …

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Married people are less likely to develop dementia

Married people are less likely to experience dementia as they age, according to new research. On the other hand, divorcees are about twice as likely as married people to develop dementia, the study indicates, with divorced men showing a greater disadvantage than divorced women. The researchers analyzed four groups of unmarried individuals: divorced or separated, widowed, never married, and cohabi

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More rain yet less water expected for up to 250 million people along the Nile

An increase in the frequency of hot and dry years could impact the water and food supplies for hundreds of millions of people in the Upper Nile region toward the end of the century.

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How blood sugar levels affect risks in type 1 diabetes

A major new study on the association between blood glucose levels and risks of organ impairment in people with type 1 diabetes can make a vital contribution to diabetes care, in the researchers' view.

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Cell biology: Potential drop signals imminent danger

Misfolded proteins must be promptly eliminated as they can form toxic aggregates in cells. Biologists have studied how this process is triggered in mitochondria and identified a general alarm signal that activates it.

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Exercise to Sleep Better (and Vice Versa!)

If you’re not sleeping well, you may not be reaching your life goals, let alone your fitness goals — Read more on ScientificAmerican.com

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Enhancing sustainability of fracking via innovations in wastewater management

Researchers from the Texas A&M Energy Institute and the Artie McFerrin Department of Chemical Engineering are leading a major initiative to reduce the amount of water needed in the natural gas extraction process, and to treat wastewater so that it is safe for reuse. Since the early 2000s, hydraulic fracturing has been the main natural gas extraction process in the United States. The effectiveness

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Molecular big data, a new weapon for medicine

Being able to visualize the transmission of a virus in real-time during an outbreak, or to better adapt cancer treatment on the basis of the mutations present in a tumor's individual cells are only two examples of what molecular Big Data can bring to medicine and health globally.

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More rain yet less water expected for up to 250 million people along the Nile

An increase in the frequency of hot and dry years could impact the water and food supplies for hundreds of millions of people in the Upper Nile region toward the end of the century.

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Here’s what would follow US-Russia nuclear war

If the United States and Russia waged an all-out nuclear war, much of the land in the Northern Hemisphere would be below freezing in the summertime, with the growing season slashed by nearly 90% in some areas, according to a new study. Indeed, death by famine would threaten nearly all of the Earth’s 7.7 billion people, says coauthor Alan Robock, a professor in the environmental sciences departmen

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Gaia untangles the starry strings of the Milky Way

Rather than leaving home young, as expected, stellar 'siblings' prefer to stick together in long-lasting, string-like groups, finds a new study of data from ESA's Gaia spacecraft.

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AI learns to model our Universe

Researchers have successfully created a model of the Universe using artificial intelligence, reports a new study.

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Model: Drastic ash tree dieback in U.K. unless breeding program instituted

Matthew Evans, a biology professor at the University of Hong Kong, has created a computer model that shows the likely impact of dieback disease on ash trees in the U.K. In his paper published in the journal Royal Society Open Science, he describes the model and what he believes resource managers can do to reduce the loss of trees.

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Sea level rises mean some towns must now decide to abandon or defend

Rising sea levels mean that a managed retreat for coastal communities is no longer a case of if, but when and how

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SpaceX’s Starhopper Aces Test Flight to Almost 500 Feet

One Big Hop SpaceX’s Starhopper finally launched itself some 150 meters (492 feet) into the air Tuesday evening at the company’s Boca Chica test facility in Texas. The company’s 20-meter Starship test vehicle, lovingly nicknamed “R2D2’s Dad,” by SpaceX CEO Elon Musk, reached its FAA-approved maximum height, flew sideways, and gently made its way down to a landing nearby. “One day Starship will la

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Model: Drastic ash tree dieback in U.K. unless breeding program instituted

Matthew Evans, a biology professor at the University of Hong Kong, has created a computer model that shows the likely impact of dieback disease on ash trees in the U.K. In his paper published in the journal Royal Society Open Science, he describes the model and what he believes resource managers can do to reduce the loss of trees.

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Law enforcement 'use of force' study moves forward

In 2017, University of Alabama researchers began studying responses and brain activity of law enforcement officers in virtual "shoot/don't shoot" situations. Their goal was to address incidents of the officers' use of force by using neural data to help improve police training and officer selection.

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The role of GABA neurons in the central circadian clock

The research team led by Dr. Daisuke Ono and Prof. Akihiro Yamanaka of the Graduate School of Medicine, Nagoya University, along with collaborators, has revealed that inhibitory neurons (GABAergic neurons) of the central circadian clock in the suprachiasmatic nucleus (SCN) refine circadian output rhythms.

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Smarter experiments for faster materials discovery

A team of scientists have designed, created, and successfully tested a new algorithm to make smarter scientific measurement decisions. The algorithm, a form of artificial intelligence (AI), can make autonomous decisions to define and perform the next step of an experiment.

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Signal blocks stem cell division in geriatric brain

Scientists have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation. According to the researchers, the gene regulator Id4 controls whether stem cells remain in a state of rest or enter cell division. The results may be relevant for treating neurodegenerative disease in human brains.

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Europe warming faster than expected due to climate change

Climate change is increasing the number of days of extreme heat and decreasing the number of days of extreme cold in Europe, posing a risk for residents in the coming decades, according to a new study.

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Could marriage stave off dementia?

Dementia and marital status could be linked, according to a new study that found married people are less likely to experience dementia as they age.

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Isotopes in feces show where secretive jaguars hunt

To track secretive jaguars in the forested mountains of Belize, biologists turned to geology and feces analysis. Researchers discovered that jaguar scat reveals where the big cats were hunting in the mountains of Belize. It's a powerful technique for wildlife conservation.

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High-protein bedtime snacks no problem for active women

In a study of women weight lifters, nutrition scientists showed that protein consumption before bed compared to protein consumption during the day does not disturb overnight belly fat metabolism or whole-body fat burn.

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Newly discovered giant planet slingshots around its star

Astronomers have discovered a planet three times the mass of Jupiter that travels on a long, egg-shaped path around its star. If this planet were somehow placed into our own solar system, it would swing from within our asteroid belt to out beyond Neptune. Other giant planets with highly elliptical orbits have been found around other stars, but none of those worlds were located at the very outer re

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The role of GABA neurons in the central circadian clock

The research team led by Dr. Daisuke Ono and Prof. Akihiro Yamanaka of the Graduate School of Medicine, Nagoya University, along with collaborators, has revealed that inhibitory neurons (GABAergic neurons) of the central circadian clock in the suprachiasmatic nucleus (SCN) refine circadian output rhythms.

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Devices that will elevate your watching to 4K Ultra Blu-Ray

BluRay players can help you get the most of out your 4K TV. (Wang John via Unsplash/) Right up front, let’s get the basics out of the way: The differences between 1080p and 4K are relatively minute, and depend more on TV size and seating distance than it does the actual hardware. If you are seated within five feet of a 60-inch TV (not the most likely of scenarios), you’ll see the difference. Simi

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Researchers develop better method to remove toxic dyes from wastewater

Using specially created nanofiber webs allows sunlight to decay the dyes safely, inexpensively and easily.

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Entangling photons generated millions of miles apart

A team of researchers with members from China, Germany, the U.K. and the U.S. has found a way to entangle photons generated millions of miles apart. In their paper published in the journal Physical Review Letters, the researchers describe this feat and how it might be used to study properties of the sun.

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Wind mystery inside gas giant Saturn begins to unravel

A new study argues that Saturn's interior flows like honey due to its magnetic field, which may help solve the mystery of why the planet's powerful winds stop 8,500km inside the giant gas planet.

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Visions of the future: Five dark warnings from the world of classic science fiction

Science fiction is brimming with visions of the future and the many wondrous things the human race can achieve. But it is full of warnings too—and we should be careful to take heed of some of the big messages that are more relevant now than they ever were before.

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Smarter experiments for faster materials discovery

A team of scientists from the US Department of Energy's Brookhaven National Laboratory and Lawrence Berkeley National Laboratory designed, created, and successfully tested a new algorithm to make smarter scientific measurement decisions. The algorithm, a form of artificial intelligence (AI), can make autonomous decisions to define and perform the next step of an experiment. The team described the

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Ranking cities around the world by transportation accessibility

A trio of researchers at the Polytechnic University of Turin has ranked the major cities of the world by transportation accessibility to highlight inequality in major urban areas. In their paper published in the journal Royal Society Open Science, Indaco Biazzo, Bernardo Monechi and Vittorio Loreto describe their study and explain what it shows.

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Pavlov's classical conditioning inspires materials scientists

Researchers have successfully trained a material to respond to an originally neutral stimulus, a gel that can be taught to melt without needing heating. Their work, recently published in Nature Communications, was inspired by the concept of classical conditioning in behavioural psychology, better known as Pavlov's dog experiment.

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Rare Caribbean gecko given highest level of protection under CITES

The Union Island gecko, found only in St Vincent & the Grenadines, is to be listed under Appendix I of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES).

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Birds of a feather flock together, but only in similar climates

One might assume that birds of flight are cosmopolitan travelers, and bird species should be distributed far and wide, spread across long distances—continents even. However, a study led by Alex White, Ph.D., a former University of Chicago graduate student now at National Museum of Natural History in Washington, D.C, shows that a bird has strong ties to the climate patterns of its habitat. As a res

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Unusual mucous-like substance found buried within seafloor sediment

When Friederike Gründger and her team cracked open the long, heavy cylinders of black sediment drawn from the ocean floor, they were surprised to find pockets of yellowish-green slime buried within two of the samples. The average person may not consider the appearance of such unseemly goo as a cause for celebration, but the biologists knew that this slime, otherwise known as biofilm, was a highly

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Europe warming faster than expected due to climate change

Climate change is increasing the number of days of extreme heat and decreasing the number of days of extreme cold in Europe, posing a risk for residents in the coming decades, according to a new study.

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Engineers develop bone-like metal foam that can be 'healed' at room temperature

For 6,000 years, humans have been making things from metal because it's strong and tough; a lot of energy is required to damage it. The flip side of this property is that a lot of energy is required to repair that damage. Typically, the repair process involves melting the metal with welding torches that can reach 6,300 °F.

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Rare Caribbean gecko given highest level of protection under CITES

The Union Island gecko, found only in St Vincent & the Grenadines, is to be listed under Appendix I of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES).

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Birds of a feather flock together, but only in similar climates

One might assume that birds of flight are cosmopolitan travelers, and bird species should be distributed far and wide, spread across long distances—continents even. However, a study led by Alex White, Ph.D., a former University of Chicago graduate student now at National Museum of Natural History in Washington, D.C, shows that a bird has strong ties to the climate patterns of its habitat. As a res

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The Trump Administration Sides With Nurses Who Object to Abortion

Under Donald Trump, departments across the executive branch have made religious freedom a clear priority , and nowhere has that agenda been more prominent than at the Department of Health and Human Services, or HHS. This morning, HHS officials will announce a new notice of violation, alleging that a major university medical center in Vermont forced a nurse to violate her conscience by assisting w

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What's private depends on who you are and where you live

Citizens and policymakers around the world are grappling with how to limit companies' use of data about individuals—and how private various types of information should be. But anthropologists like me know that cultures vary widely in their views of what is private and who is responsible for protecting privacy. Just like online privacy, real-world privacy can vary from person to person and situatio

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Possible Detection of a Black Hole So Big It ‘Should Not Exist’

Black hole physicists have been excitedly discussing reports that the LIGO and Virgo gravitational-wave detectors recently picked up the signal of an unexpectedly enormous black hole, one with a mass that was thought to be physically impossible. “The prediction is no black holes, not even a few” in this mass range, wrote Stan Woosley , an astrophysicist at the University of California, Santa Cruz

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Shameless thief or good forest citizen? Weka bring hidden benefits to New Zealand forests

Weka are often portrayed as little more than sandwich-stealing scallywags. The large, brown flightless bird's tendency to be curious and gobble any food available (whether it be an unwatched biscuit, penguin egg or endangered gecko) also makes them troublesome for conservationists. However, a new study by University of Canterbury and Department of Conservation researchers has found that these char

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Cluster and XMM-Newton pave the way for SMILE

A joint European-Chinese spacecraft, SMILE is currently scheduled for launch in 2023. It will be placed in a highly inclined, elliptical orbit around Earth, which will take it as far as 120 000 km from our planet.

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Scientists forecasted late May tornado outbreak nearly four weeks before it ripped through U.S.

A team of scientists reports that they accurately predicted the nation's extensive tornado outbreak of late May 2019 nearly four weeks before it began.

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Protecting the Amazon requires changing policy and eating less beef

The Amazon forests of Brazil, Peru, and Bolivia are burning to death. The Amazon, which covers 2.1 million square miles, is often referred to as the "lungs of the planet" because it's thought to produce 20 percent of the oxygen in our planet's atmosphere, and take in 17 percent of the carbon dioxide stored by the world's trees.

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Shameless thief or good forest citizen? Weka bring hidden benefits to New Zealand forests

Weka are often portrayed as little more than sandwich-stealing scallywags. The large, brown flightless bird's tendency to be curious and gobble any food available (whether it be an unwatched biscuit, penguin egg or endangered gecko) also makes them troublesome for conservationists. However, a new study by University of Canterbury and Department of Conservation researchers has found that these char

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Bones pulled from the La Brea Tar Pits show the perils of being a picky eater

Narrow rows of shallow gray bins tower to the ceiling. Resting inside are the jaw bones of saber-toothed cats and ancient coyotes that perished in the La Brea Tar Pits as many as 40,000 years ago.

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Climate change in a coastal county: Think global, act hyperlocal

Of all the communities across the United States wrestling with climate change, few face its effects day to day like the strand of coastal islands that make up Dare County.

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Fresh water found in the Norwegian Sea

The discovery was made at 800 meters below the surface in two small canyons on the continental slope outside Lofoten archipelago.

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A PoEM on breast cancer metastasis

When breast cancer cells spread through the body, they do so mainly through the lymph system that normally removes excess fluid and waste products from our tissues. Now, scientists from the group of Professor Massimiliano Mazzone (VIB-KU Leuven Center for Cancer Biology) identified a novel subset of immune cells, called Podoplanin-expressing macrophages (PoEMs), that change the tissues near a tumo

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Isotopes in poop show where secretive jaguars hunt

To track secretive jaguars in the forested mountains of Belize, the University of Cincinnati turned to geology and poop. Researchers discovered that jaguar scat reveals where the big cats were hunting in the mountains of Belize. It's a powerful technique for wildlife conservation.

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Science wages a battle against the swine sector's costliest virus

A research team at the University of Córdoba has compared the behavior of two different strains of the Porcine Reproductive and Respiratory Syndrome Virus, to expedite the production of an effective vaccine in the future.

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AI learns to model our Universe

An international team has used AI to create a 3D simulation of the Universe.

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High-protein bedtime snacks no problem for active women

In a study of women weight lifters, nutrition scientists at FSU showed that protein consumption before bed compared to protein consumption during the day does not disturb overnight belly fat metabolism or whole-body fat burn.

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Could marriage stave off dementia?

Dementia and marital status could be linked, according to a new Michigan State University study that found married people are less likely to experience dementia as they age.

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Signal blocks stem cell division in the geriatric brain

Scientists from Basel have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation. According to the researchers, the gene regulator Id4 controls whether stem cells remain in a state of rest or enter cell division. The results were published in "Cell Reports" and may be relevant for treating neurodegenerative disease in human bra

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You’ll Hail Your First Flying Taxi Within a Decade

Not too long ago, the notion of flying cars was most comfortably categorized alongside fusion power—a classic tech vision that seemed forever stuck just over the horizon. Then around five years ago something shifted. Flying cars suddenly appeared plausible again. And not just “roadable planes” or “personal helicopters.” The renewed vision was a flying car (or taxi) for the masses, no pilot’s lice

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Test for organic produce detects food fraud

A new method can determine whether an “organic” piece of produce is legit or fraudulently labeled. By looking at fertilizer for organic plants, the method provides a deeper, more accurate portrayal of whether eco-labelled produce is indeed organic. According to experts, imported organic fruits and vegetables are susceptible to food fraud. Increased consumer demand and higher profits for producers

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Not All Of Those Compounds Are Real. Again.

The Nrf2 pathway has been a hot area of research for some years now, particularly in oncology. It’s a basic-leucine-zipper transcription factor that under normal conditions stays mostly out in the cytosol, where it’s under tight regulatory control. Under cellular stress, though, it heads into the nucleus and fulfills its transcription-factor destiny, in particular setting off a range of genes cod

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Lego offers instructions for visually impaired builders

All Lego sets come with visual instructions that indicate where builders should place each piece. But such guidance isn't accessible for the blind. The Lego Foundation today announced …

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LG, Panasonic, and Vizio introducing 'Filmmaker Mode' that shows movies as they were intended

The mode will automatically disable any motion smoothing features a TV may have, which is often enabled as a default setting. The much-maligned feature involves the creation of artificial frames …

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Self-Driving Racecars Are Edging Up Toward Human Records

Fast & FurAIous A self-driving racecar league called the Roborace motorsport competition is in its first competitive season, and teams are already hot on the trail of human-set records. In a race last month, one team programmed the electric, self-driving car to handle an obstacle course so well that it finished just 12 seconds behind the current record for any driver, biological or robotic, accor

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Millennials, think you're digitally better than us? Yes, according to science

Legend has it that millennials, specifically the 'Net Generation,' masterfully switch from one technology to the next. They claim that it's easy and that they can do it better than older generations. Research, so far, hasn't proven this claim. A new study provides some of the first results on whether or not "Net Genners" are developing greater digital literacy than generations before them, and i

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How blood sugar levels affect risks in type 1 diabetes

A major new study on the association between blood glucose levels and risks of organ impairment in people with type 1 diabetes can make a vital contribution to diabetes care, in the researchers' view.

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Cell biology — Potential drop signals imminent danger

Misfolded proteins must be promptly eliminated as they can form toxic aggregates in cells. Ludwig-Maximilians-Universitaet (LMU) in Munich biologists have studied how this process is triggered in mitochondria and identified a general alarm signal that activates it.

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Unusual mucous-like substance found buried within seafloor sediment

The location and microbial composition of recently found biofilms are challenging beliefs about methane diffusion.

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How your brain remembers motor sequences

Researchers at the National Institute of Information and Communications Technology (NICT), Japan, and Western University, Canada, have succeeded in visualizing how information is represented in a widespread area in the human cerebral cortex during a performance of skilled finger movement sequences. The results uncovered the first detailed map of cortical sequence representation in the human brain.

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Europe warming faster than expected due to climate change

Climate change is increasing the number of days of extreme heat and decreasing the number of days of extreme cold in Europe, posing a risk for residents in the coming decades, according to a new study.

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Italy's Stromboli volcano erupts anew, spewing fiery lava

The Stromboli volcano has erupted, spewing fiery chunks of lava onto the tiny Italian island and alarming residents and tourists.

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Recognising intersex people opens access to fundamental rights in Kenya

Kenya has become the first country in Africa to collect data on intersex people in its national census which runs to the end of August. Intersex refers to people born with physical characteristics that do not fit the typical definitions of male or female. Boniface Ushie responds to questions on the context and significance of Kenya's decision.

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Organ-on-a-chip: 3-D self-rolled biosensor array to electrically interrogate electrogenic cells

Cell to cell communication plays an important role in coordinating the function of biological systems. Three-dimensional (3-D) spheroids (cell aggregates) allow biologists to explore cellular communication during tissue development and drug discovery since their 3-D architecture can mimic in vivo microenvironments in the lab. Cellular electrophysiology is an existing signaling technique to study e

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Become a portrait mode pro

A blurred background means a ton of likes. (Allef Vinicius via Unsplash/) Portrait mode photos are everywhere these days. Some shots look great, others… don’t. So if you want your pics to really stand out, there are certain techniques you need to know. Since it was introduced with the iPhone 7 Plus in September 2016, some kind of portrait mode has been available on most flagship phones, including

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Organ-on-a-chip: 3-D self-rolled biosensor array to electrically interrogate electrogenic cells

Cell to cell communication plays an important role in coordinating the function of biological systems. Three-dimensional (3-D) spheroids (cell aggregates) allow biologists to explore cellular communication during tissue development and drug discovery since their 3-D architecture can mimic in vivo microenvironments in the lab. Cellular electrophysiology is an existing signaling technique to study e

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Teen Climate Activist Greta Thunberg Arrives In New York After Sailing The Atlantic

The 16-year-old Swedish activist chose sailing over flying to attend a United Nations climate summit. She's inspired young people around the world to protest for more climate action. (Image credit: Mary Altaffer/AP)

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Sex robots increase the potential for gender-based violence

Sex robots made headlines after American comedian Whitney Cummings brought out her very own lookalike robot for her Netflix special called Can I Touch It? RealBotix, the company that made Cummings' robot, says that since the special, there has been a wave of demand for their robots.

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Meet the Guy Tesla Fired, Who Now Fixes Roadsters

Repairing Roadsters Carl Medlock started working as a territory manager for Tesla in 2009, back when the company only produced one type of car: Roadsters. By the time the company laid him off in 2013, it has already stopped making the vehicles, and today, Roadster owners often have little recourse but to seek out a specialist if something goes wrong with their car. And for many, Medlock is that s

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Simple solutions to soundproof your apartment

Soundproofing gear to help manage your (and your neighbor's) noise. (Haley Powers via Unsplash/) You’ve just moved into a new apartment—exciting! But there's one little issue. You can hear the doors slam. The cars on the outside street are louder than you’d thought. What’s that buzzing sound? There are endless external noises like this, especially if you’re in a big city. It’s probably impractica

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Probiotic use can lead to major economic and health savings related to flu-like illnesses

General probiotic use in the US could save the health care payer and the economy around $1.4 billion in medical bills and lost productivity due to acute respiratory tract infections (RTIs), a new study found. The researchers developed an economic model to estimate the cost savings by simulating a population representative of the national demographics. The savings included the averted cost of antib

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Millennials, think you're digitally better than us? Yes, according to science

Legend has it that millennials, specifically the 'Net Generation,' masterfully switch from one technology to the next. They claim that it's easy and that they can do it better than older generations. Research, so far, hasn't proven this claim. A new study provides some of the first results on whether or not "Net Genners" are developing greater digital literacy than generations before them, and if

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Start-ups must be aware of star employee pitfalls

The presence of both a star inventor and founder within a company has a positive effect on the firm's performance, but when you have both of them together on a team, the outcomes can become diminished.

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The reality behind cannabidiol’s medical hype

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02524-5 The cannabis compound known as CBD is being touted as a treatment for a variety of conditions. But the substance’s uncertain legal status is stalling serious investigation.

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Regulators need to rethink restrictions on cannabis research

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02531-6 Policy changes are needed to support crucial work in the United States, says Jahan Marcu.

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The professionalization of cannabis growing

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02527-2 As the wave of legalization advances, a budding industry is adopting the high standards of consumer-product makers to meet regulatory requirements.

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Cannabis research round-up

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02532-5 Highlights from laboratory studies and clinical trials.

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Spørg Fagfolket: Påvirker klimaforandringerne DMI’s vejrmodeller?

En læser vil gerne vide, om vejrets forandringer forårsager bøvl med DMI’s vejrmodeller. Det svarer DMI selv på.

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Climate explained: How emissions trading schemes can help us shift to a zero carbon future

Every tonne of emissions causes damages and a cost to society. In traditional market transactions, these costs are ignored. Putting a price on emissions forces us to face at least some of the cost of the emissions associated with what we produce and consume, and it influences us to choose lower-emission options.

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Fitbit Announces Versa 2 Smartwatch With Alexa

Product render of Fitbit Versa 2 inbox and Special Edition family. The design is cleaner and more refined, and there's support for voice commands …

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Under pressure: Balloons for particle acceleration

Balloons can help make a space perfect for a party. Now they also can help when it comes to accelerating particles to near the speed of light.

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Researchers calculating the scientific value of trees in one lush neighborhood

Perhaps more than anywhere else in Miami, the streets of Coconut Grove are dappled with sunlight and shadow. Look overhead and you'll see why.

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Researchers calculating the scientific value of trees in one lush neighborhood

Perhaps more than anywhere else in Miami, the streets of Coconut Grove are dappled with sunlight and shadow. Look overhead and you'll see why.

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Six pro audio interfaces for home recording

Record a full band at home. (Wes Hicks via Unsplash/) There once was a time when music recording was synonymous with pricey studio rates, gigantic mixing consoles, and finicky tape machines, but those days are long gone. It’s now easier and more affordable than ever to record a full band or ensemble at home. The prevalence of computers and the rise of microprocessing technology have ushered in a

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Fitbit Premium, Versa 2, Aria Air: Pricing, Specs, Details

The company’s new offerings include two fitness-tracking products, a subscription service for personalized health advice, and lots and lots of partnerships.

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Big Ag Is Sabotaging Progress on Climate Change

Opinion: Grim as the UN’s latest climate report is, it doesn’t confront the dangerous, government-hijacking power of agribusiness.

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Flint, Newark, and the Persistent Crisis of Lead in Water

The contaminated water in Flint and Newark is not unusual, and some experts think they know where the next "next Flint" will be.

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Pregnant women of color experience disempowerment by health care providers

A new study finds that women of color perceive their interactions with doctors, nurses and midwives as being misleading, with information being 'packaged' in such a way as to disempower them by limiting maternity healthcare choices for themselves and their children.

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Newly discovered giant planet slingshots around its star

Astronomers have discovered a planet three times the mass of Jupiter that travels on a long, egg-shaped path around its star. If this planet were somehow placed into our own solar system, it would swing from within our asteroid belt to out beyond Neptune. Other giant planets with highly elliptical orbits have been found around other stars, but none of those worlds were located at the very outer re

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Star laws: What happens if you commit a crime in space?

NASA is reportedly investigating what could be the first ever alleged crime in space. Astronaut Anne McClain has been accused of accessing her estranged spouse's bank account via the internet while on board the International Space Station (she denies the accusation).

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Astronomers detect an ultracompact X-ray binary using OGLE

Polish astronomers have detected a new ultracompact X-ray binary as part of the Optical Gravitational Lensing Experiment (OGLE). The newly found binary, designated OGLE-UCXB-01, is an unusual periodic variable object with a relatively short orbital period. The finding is reported in a paper published August 22 on the arXiv pre-print server.

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Cannabis

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02523-6 A field in flux.

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Weighing the dangers of cannabis

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02530-7 As interest builds in the potential health benefits from the plant, accumulating evidence confirms that taking the drug also carries risks.

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Can cannabis go green?

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02526-3 With its demand for water, land and artificial lighting, cannabis growing can leave a large environmental footprint. But heightened awareness could make cultivation more benign.

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Working out with weed

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02529-0 Scientists investigate the counter-intuitive connections between exercise and cannabis.

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The bioengineering of cannabis

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02525-4 Genetic modification could enable industrial-scale production of cannabinoids that have pharmaceutical potential.

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Cannabis’s chemical synergies

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02528-1 The notion of an ‘entourage effect’ that magnifies the drug’s effects is intriguing but lacks solid evidence.

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Car mounts that keep your phone handy and secure

Never look at your lap to reference Google Maps again. (Dan Gold via Unsplash/) We spend a lot of time on our phones and in our cars—often simultaneously. But in 20 states, it's illegal to use a handheld cell phone while driving , and 48 states have banned texting while behind the wheel. Still, in certain states like California, it's legal to use your phone "hands-free" if it's mounted securely t

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Nuclear winter would threaten nearly everyone on Earth

If the United States and Russia waged an all-out nuclear war, much of the land in the Northern Hemisphere would be below freezing in the summertime, with the growing season slashed by nearly 90 percent in some areas, according to a new study. Indeed, death by famine would threaten nearly all of the Earth's 7.7 billion people, according to the research.

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Is the Mathematical World Real?

Philosophers cannot agree on whether mathematical objects exist or are pure fictions — Read more on ScientificAmerican.com

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Boris Johnson Is Suspending Parliament. What’s Next for Brexit?

With two months to go before Britain is due to exit the European Union, the country is mired in political dysfunction; its political leaders agree on little, if anything; and the terms on which Britain will leave the EU are yet to be agreed on. Now, then, seems like the perfect time for Boris Johnson to up the stakes even further. The prime minister went to the queen today to request that Parliam

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Conservatives make the best investors, according to study

When it comes to investing, conservatives may have a built-in advantage, according to a study by business scholars at Rice University, the University of North Carolina (UNC) at Chapel Hill, the University of Texas at San Antonio (UTSA), the University of Bath and Southern Methodist University (SMU).

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Drottningen – från landsmor till idealbild

Ulrika Elonora av Danmark, Lovisa Ulrika av Preussen, Sofia Magdalena av Danmark och Josefina av Leuchtenberg. Trots stora politiska förändringar under 1600-, 1700- och 1800-talen tycks drottningrollen påverkas förvånansvärt lite under den tidsperioden. – Det går sällan att knyta bilden av drottningarna till ett specifikt styre. Drottningens funktion i samhället, och i förlängningen hela monarkin

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Oranga Tamariki baby removals "racialised, regionalised, antenatal and coercive"

Newly analyzed figures from Oranga Tamariki show the number of babies being taken from their parents are overwhelmingly Māori, hail mostly from four distinct North Island regions, and are more frequently than ever removed by legal order before birth.

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'Green peas' provide clues to the early days of the universe

It is probable that primordial galaxies triggered the period in the history of the universe known as "cosmic reionization." The Geneva-based astronomer Anne Verhamme has succeeded in demonstrating this by studying green pea galaxies. In recognition of this work, the SNSF will award her this year's Marie Heim-Vögtlin prize on 16 September 2019.

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New, fundamental limit to 'seeing and believing' in imaging

Answers to big questions increasingly require access to the realm of the very small.

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New antimicrobial coating could be key in fight against hospital-acquired infections

Scientists at the University of Birmingham have created an antimicrobial coating for steel surfaces which has proven to rapidly kill bacteria that cause some of the most common hospital-acquired infections.

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Scientists call for infiltration to be better incorporated into land surface models

Soil scientists can't possibly be everywhere at once to study every bit of soil across the planet. Plus, soils are constantly changing.

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Parental burnout can lead to harmful outcomes for parent and child

When the daily stress of parenting becomes chronic it can turn into parental burnout, an intense exhaustion that leads parents to feel detached from their children and unsure of their parenting abilities, according to new research. This type of burnout can have serious consequences for both parent and child, increasing parental neglect, harm, and thoughts about escape.

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Using artificial intelligence to track birds' dark-of-night migrations

Researchers have unveiled a machine learning system called 'MistNet' to extract bird data from the radar record and to take advantage of the treasure trove of bird migration information in the decades-long radar data archives.

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Popular pain medication associated with greater risk of hypoglycemia

As the opioid tramadol has grown in popularity so too have documented cases of adverse effects. In a new study, researchers show that patients who take tramadol are at greater risk for hypoglycemia, abnormally low blood sugar.

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Turbocharging the body's natural killer cells to defeat cancer

Natural Killer (NK) cells have long been the soldiers of the immune system that prevents the growth and spread of cancers, and subduing this army of cells is one of the key ways that tumours take hold. Researchers have discovered a protein that prevents NK cells from doing their job fighting cancer. Importantly the study reveals that blocking this protein turbo charges the immune system to fight o

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Jupiter shows its true stripes

There's a reason why Jupiter's stripes are only skin deep.

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VIDEO: Gør regnstatistikken bedre – inddrag vejrradar

Nedbørsstatistik spiller en central rolle i klimasikringplaner og forsikringsvurderinger. Den bør derfor være præcis – og det er den ikke, når den kun baseres på punktmålinger fra landjorden. Radardata bør også indgå, fastslår Envidan i dette videosynspunkt.

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UK police are using AI to spot spikes in Brexit-related hate crimes

The UK police are monitoring hundreds of thousands of Twitter posts every day to try to predict spikes in hate crime in the run up to the UK's exit from the European Union

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Water microdroplets spontaneously make hydrogen peroxide

Water microdroplets spontaneously produce hydrogen peroxide, research finds. The discovery could pave the way for greener ways to produce the molecule, a common bleaching agent and disinfectant, says Richard Zare, professor in natural science and of chemistry at Stanford University. “Water is one of the most commonly found materials, and it’s been studied for years and years and you would think t

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Google is shutting down another service – CNET

Google Hire will close in September 2020.

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Harvard Student Has Visa Cancelled Following Social Media Posts

In case you didn’t know, if you’re planning on applying for a visa to enter the US, whether it be for work, study, or holiday, you will need to submit your social media information …

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Microsoft Surface Pro 6 Deal: $270 Off Right Now

Microsoft's laptop-tablet hybrid is as cheap as we've seen it.

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Best Running Clothes for Hot Days: Shorts, Shirts, and Gear

It's incredibly hot this year. If you're going for a run, be sure to wear the right clothes and stay hydrated. Here's how we do it at WIRED.

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Why Denying Migrants Flu Shots Is a Dangerous, Foolish Move

Putting folks at higher risk of infectious disease by holding them in cramped, unhygienic camps is a public health travesty. It’s also probably illegal.

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Seeds travel

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02522-7 Plotting a route.

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Image of the Day: Liquid Compartments

Membraneless organelles appear highly sensitive to ion concentrations in their environment.

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'Dangerous' AI offers to write fake news

submitted by /u/trot-trot [link] [comments]

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Kontroversiel psykiater må igen arbejde som psykiater – med forbehold

Styrelsen for Patientsikkerhed har ophævet psykiater Lars Søndergårds virksomhedsindskrænkning og skærpede tilsyn. Ifølge lektor i sundhedsjura betyder det, at han atter må arbejde som psykiater i Danmark – dog i en stækket udgave.

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Gluten Update

Non-celiac gluten sensitivity remains controversial, but the research continues.

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Amazon fires: Forest loss challenges Paris climate ambition

Fossil fuel burning is the big issue but continued forest cover loss will make climate targets harder to achieve, say scientists.

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An army of hungry little sea urchins could save Hawaiian reefs

A diver holding urchins just 15 to 20 millimeters in width. The animals, native to Hawai’i, are known to eat at least five species of invasive algae. (Hawaii Division of Aquatic Resources/) There are a lot of stories of introduced species gone wrong. In Hawai'i, for example, the mongoose was initially brought in to control rats. But the effort missed a crucial point—mongooses feed in the daytime,

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Landsbygdsbor i rika länder allt fetare

– Klart oroande. Att svälten i världen minskar är givetvis i grunden väldigt positivt, men tyvärr verkar det som att länder på ekonomisk uppgång gärna tar efter det sämsta av den rika världens vanor, säger Stefan Söderberg, professor i kardiologi vid Umeå universitet och ansvarig för en av de svenska studier som ingår i den internationella studien. Män med stillasittande jobb och kulmage, är en k

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Red wine drinkers have more diverse gut bacteria than other drinkers

Drinking red wine may be better for your microbiome than drinking other types of alcohol, according to a study of 3000 people

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Vi læger skal tage ledelse på os

Vi har som læger brug for at lære, hvad moderne ledelse er. Derfor skal universiteterne lære de kommende læger, hvad ledelse i sundhedsvæsenet er, skriver ledende overlæge Inger Brødsgaard.

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Robert Mueller Wanted the Facts to Speak for Themselves–Bad Move

The former special counsel’s frequently one-word answers in his August testimony gave little more insight into the report than the misinformation that’s already out there — Read more on ScientificAmerican.com

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Farmers, researchers try to hold off deadly citrus greening long enough to find cure

In an orange grove outside Exeter, California, workers climb aluminum ladders to pick fruit with expert speed. California produces 80 percent of the nation's fresh oranges, tangerines and lemons, most of it in small Central California communities like these.

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This Google Play App's Ticking Malware Time Bomb Just Exploded Leaving 100 Million At Risk

There's trouble brewing in the Google Play Store… again. This time the threat comes from CamScanner, which for quite some time has been a popular app that allows Android users to create PDF …

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Facebook tightens rules for political ads ahead of US elections

Facebook said Wednesday it would tighten its rules for political ad spending ahead of the 2020 US elections, notably by requiring more information about who is paying for campaign messages.

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To Hunt Gravitational Waves, Scientists Had to Create the Quietest Spot on Earth

The largest physics detector on Earth hunts gravitational waves. But it needs to be really, really quiet to find them.

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Quantum Gravity Could Reverse Cause and Effect

Any theory of quantum gravity is going to have to grapple with some weird time stuff.

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Western Diamondback Rattlesnake

The western diamondback rattlesnake is the largest of the 32 known species of rattlesnakes found in North America. Here's how you can tell it's the western diamondback.

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Farmers, researchers try to hold off deadly citrus greening long enough to find cure

In an orange grove outside Exeter, California, workers climb aluminum ladders to pick fruit with expert speed. California produces 80 percent of the nation's fresh oranges, tangerines and lemons, most of it in small Central California communities like these.

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New study suggests U.S. land carbon sink may have been overestimated

A new study on agricultural land use calls into question conclusions made by previous studies that recent land-use changes have caused the United States to take up more carbon than it emits.

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Tight housing, immigration are shifting pressure onto Seattle's black neighborhoods, sociologist finds

A competitive housing market combined with the rapid rise of immigration is driving gentrification in Seattle's low-cost black neighborhoods, according to a new study by Stanford sociologist Jackelyn Hwang.

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Image: Raft of rubble

Captured by the Copernicus Sentinel-2 mission on 21 August 2019, this image features a huge raft of pumice rock drifting in the Pacific Ocean. The pumice is believed to have come from an underwater volcano near Tonga, which erupted on 7 August.

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Younger scientists need better support

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02561-0 Universities must accept that there will be consequences if early-career researchers are not properly supported.

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Amazon fires: South American countries to meet to discuss response

Brazil's President Bolsonaro also reveals he has accepted help from Chile, after rejecting a G7 offer.

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Lessons on parasitism from the curious Dicyemida

The incredible diversity of life forms on the planet led Charles Darwin to note, "From so simple a beginning, endless forms most beautiful and most wonderful have been, and are being, evolved." In order to gain a true understanding of the power and limitations of evolution to produce such "endless forms," it is important to study a variety of organisms from across the tree of life. Luckily, next-g

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No One's Happy With YouTube's Content Moderation Policies

YouTube faces dueling lawsuits from a conservative group and an LGBTQ+ group, both of which argue that the video site discriminates against them.

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Who's Burning the Amazon? Rampant Capitalism

Market forces and the administration of Jair Bolsonaro are supercharging the deforestation that's imperiling the world's biggest tropical rainforest.

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Lessons on parasitism from the curious Dicyemida

The incredible diversity of life forms on the planet led Charles Darwin to note, "From so simple a beginning, endless forms most beautiful and most wonderful have been, and are being, evolved." In order to gain a true understanding of the power and limitations of evolution to produce such "endless forms," it is important to study a variety of organisms from across the tree of life. Luckily, next-g

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Researchers develop new information tool to standardize clinical outreach to unsheltered homeless

Researchers from the street medicine team at the Keck School of Medicine of USC have developed "HOUSED BEDS," the first published tool designed specifically to help outreach teams clearly assess the situation of unsheltered homeless patients. This memory-prodding acronym can help clinicians ask high-yield questions and gather vital information necessary to providing quality care tailored to the ne

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16 inventions getting us off fossil fuels and into renewable energy

submitted by /u/bebesiege [link] [comments]

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Venomous Brown Recluse Spider Crawls into Woman's Ear

Susie Torres didn't expect that the strange 'swishing noise' she was hearing would turn out to have eight legs.

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Robert Mueller Wanted the Facts to Speak for Themselves–Bad Move

The former special counsel’s frequently one-word answers in his August testimony gave little more insight into the report than the misinformation that’s already out there — Read more on ScientificAmerican.com

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New Elevation Measure Shows Climate Change Could Quickly Swamp the Mekong Delta

The surprise revelation means 12 million Vietnamese may need to retreat — Read more on ScientificAmerican.com

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Förlossningsdepression påverkar föräldrarna i åratal

– Både mammor och pappor beskrev upplevelser av otillräcklighet som mest stressande, berättar Maude Johansson. Graviditetsproblem och/eller en traumatisk förlossning medverkade till depression och ångest hos mödrarna och påverkade också fäderna negativt. Maude Johansson har studerat förekomsten av PPD och föräldrastress hos båda föräldrarna 25 respektive 30 månader efter förlossningen, hos 700 mö

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New Elevation Measure Shows Climate Change Could Quickly Swamp the Mekong Delta

The surprise revelation means 12 million Vietnamese may need to retreat — Read more on ScientificAmerican.com

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SpaceX’s Starhopper has made its highest and final test flight

Starhopper, SpaceX’s prototype of the spacecraft the firm plans to use to bring humans to Mars, has made its last flight its highest ever at 150 metres up

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The pyrocene has begun: How to tackle a world of raging wildfires

Thousands of hectares of Arctic forest is on fire and the effects on human health and the climate could be terrible. Why did this happen and how can we respond?

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Use ancient remains more wisely

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02516-5 Researchers rushing to apply powerful sequencing techniques to ancient-human remains must think harder about safeguarding, urge Keolu Fox and John Hawks.

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The Boss Can Tell You to Show Up for a Trump Rally

When President Donald Trump arrived in western Pennsylvania this month to give a speech about energy policy at a Royal Dutch Shell plant, he had a ready-made audience composed of workers who, it turns out, were paid to be there. The company suggested that the event was simply a “training day” featuring an unusually prominent guest speaker, and offered that workers could take a day of paid time of

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The Gift of a Public Library

Andrew Carnegie was the force of Gilded Age philanthropy behind the building of public libraries. Along with other recognizable names who made their fortune in the late 1800s and early 1900s—Rockefeller, Ford, Mellon, Morgan, Stanford, Harriman, Heinz—Carnegie’s influence endures today largely because of the way he gave away the vast fortune he amassed. For about 35 years beginning in 1883 , Carn

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Cheering the Constitution’s Demise

“I can tell you this much,” the old-timer at the end of the bar said to me the other night while I waited to meet a friend for a Broadway show. “I don’t think that lady likes men very much.” We were at Sardi’s, and he was referring to Heidi Schreck, the writer and star of the one-act play I was about to see at the Helen Hayes Theater next door. What the Constitution Means to Me has enjoyed ecstat

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“I sincerely apologise:” UK cancer researcher calls for retraction of his work years after it’s flagged on PubPeer

A cancer researcher in England says he will be retracting a 2011 paper after acknowledging “unacceptable” manipulation of some of the figures in the article. Richard Hill, of the University of Portsmouth, this week agreed to retract the article, “DNA-PKcs binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death,” which appeared … Continue reading

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To Justify Using Weed, Pregnant Women Cling to an Old and Dubious Study

Twenty-five years ago, a graduate student published a study on cannabis use in pregnancy in rural Jamaica. One of her findings — that infants exposed to the drug did just fine — is widely cited on social media. But researchers say the study has limitations and should not be treated as evidence of safety.

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Why employees have the upper hand now more than ever before

Employee satisfaction, as a concept, didn't emerge until the rise of the industrial economy and unionization. If employees were unhappy, management could predict a strike and stoppage of work. Since then, the standard for management has been to consider employee engagement an accurate measure of satisfaction. Instead, research suggests the focus should be employee fulfillment: Do employees have t

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Ny smartphone kan skilles ad med en skruetrækker

Den hollandske mobilproducent Fairphone har netop lanceret den tredje generation af sin bæredygtige smartphone, som kan skilles ad i syv dele, og er fremstillet af 80 procent genanvendelige materialer.

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Has Kenya's plastic bag ban worked?

Plastic carrier bags were made illegal, so how has the government enforced the ban?

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How fire shaped humans, and forged the modern economy

If you rule out everything made by fire, we would not be left with much of an economy at all.

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Hackere kan tage kontrol over populært sikkerhedskamera

Usikker Weave-protokol gør Cam IQ fra Nest sårbart.

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Professor: Sociale medier skal stå til ansvar for krænkelser

Sociale medier kan gøres ansvarlige for at distribuere ulovligt materiale.

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Populær PDF-app fjernes fra Google Play efter malware-afsløring

Appen CamScanner downloadede og kørte regelmæssigt skadelig software.

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Hovedstaden vil løbende udvikle sundhedsaftale

Hovedstadens sundhedsaftale må ikke blive et pænt papir, men skal være en aftale, der bliver omsat til bedre forløb for borgerne, siger Sisse Marie Welling (SF), sundheds- og omsorgsborgmester i København og næstformand i Sundhedskoordinationsudvalget.

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Leverandører og ingeniører: Her kan det gå galt med EPS-beton

PLUS. Lav trykstyrke, fejlagtige blandingstider og manglende hærden kan føre til problemer, når letvægtsbetonen tages i brug på byggepladser.

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Popular pain medication associated with greater risk of hypoglycemia

As the opioid tramadol has grown in popularity so too have documented cases of adverse effects. In a new study, researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at UC San Diego show that patients who take tramadol are at greater risk for hypoglycemia, abnormally low blood sugar.

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New MRI computing technique can spot scar muscles of heart without damaging kidneys

3D MRI computing can measure strain in the heart using image registration method. Traditional method involves giving the patient a dose of gadolinium which can affect the kidney, researchers at WMG, University of Warwick have found.

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What makes a dictator, a guide to the apocalypse, and demythologizing language: Books in brief

Nature, Published online: 28 August 2019; doi:10.1038/d41586-019-02481-z Barbara Kiser reviews five of the week’s best science picks.

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Amazon: Vi har også oplevet brand i solpaneler fra Tesla

Amazon og Walmart vil sammen undersøge brande, der angiveligt skyldes defekte solcellepaneler fra Tesla.

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Beyond 30% Conversion Efficiency in Silicon Solar Cells: A Numerical Demonstration

Scientific Reports, Published online: 28 August 2019; doi:10.1038/s41598-019-48981-w

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Expression profiles of p53/p73, NME and GLI families in metastatic melanoma tissue and cell lines

Scientific Reports, Published online: 28 August 2019; doi:10.1038/s41598-019-48882-y

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Scientists Fertilize Eggs From the Last Two Northern White Rhinos

A mother and daughter are the only two northern white rhinoceroses left in the world. Their eggs were fertilized using sperm from males who have died.

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What’s Killing California’s Sea Otters? House Cats

The state’s beloved sea mammals have been plagued by the deadly Toxoplasma parasite. They’re catching it from feral and pet cats.

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Markedsføring af klinik møder kritik

I Lemvig har 7.000 borgere skulle tilmelde sig et nyt lægetilbud i august. Det har fået en af områdets lægeklinikker til at henvende sig direkte til borgerne i lokalavisens annoncespalter. Fremstødet har fået PLO til at klage til regionen.

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Praksis gør klar til at lægge arm

Overenskomstforhandlingerne nærmer sig. Regionerne har sat sit hold og PLO-Hovedstaden søsat den første OK21-spørgeskemaundersøgelse blandt sine medlemmer. Dagens Medicin har derfor spurgt de regionale PLO-formænd, hvilke emner der bør fylde mest.

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'Starhopper': SpaceX engine testbed makes minute-long jump

The Californian rocket company demonstrates its new methane-burning engine in Texas.

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Strengthening Cybersecurity with Artificial Intelligence

submitted by /u/MachineLearning001 [link] [comments]

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What are the real causes of Depression?

submitted by /u/BrainsandBehavior [link] [comments]

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Inhabilitet i Medicinrådets top

Set fra den kliniske slagmark tyder meget på, at aktuelle problemer skyldes, at formandsskabet i Medicinrådet også er ansat som sygehusdirektører med ansvar for den daglige drift og økonomi, skriver overlæge og professor.

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Respiratory ailments rise in Brazil as Amazon fires rage

Lingering smoke in the Amazon caused concern Tuesday among Brazilians who say that respiratory problems—particularly among children and the elderly—have increased as fires in the region rage.

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Slow boat to China: cargo ships urged to cut speed and pollution

Moving cargo ships into the slow lane, an idea French President Emmanuel Macron floated at the G7 summit in Biarritz, would be one way to cut maritime transport's giant carbon emissions footprint.

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Amazon fires a 'tipping point': forestry group chief

The fires tearing through the Amazon represent a "tipping point" for the health of the rainforest, the head of a top global forestry management body said Wednesday, urging the world to do more to save the trees.

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Can global matcha craze save Japan's tea industry?

From matcha ice cream to cake and chocolate, producers of traditional Japanese green tea are capitalising on growing global interest in its flavour—even as demand for the drink declines at home.

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Can global matcha craze save Japan's tea industry?

From matcha ice cream to cake and chocolate, producers of traditional Japanese green tea are capitalising on growing global interest in its flavour—even as demand for the drink declines at home.

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Archeologists find remains of 227 sacrificed children in Peru

Archeologists in Peru say the 227 bodies they have unearthed from a site used by the pre-Columbian Chimu culture is the biggest-ever discovery of sacrificed children.

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Scientists call for infiltration to be better incorporated into land surface models

Soil scientists can't possibly be everywhere at once to study every bit of soil across the planet. Plus, soils are constantly changing.

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Using artificial intelligence to track birds' dark-of-night migrations

On many evenings during spring and fall migration, tens of millions of birds take flight at sunset and pass over our heads, unseen in the night sky. Though these flights have been recorded for decades by the National Weather Services' network of constantly scanning weather radars, until recently these data have been mostly out of reach for bird researchers.

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Using artificial intelligence to track birds' dark-of-night migrations

On many evenings during spring and fall migration, tens of millions of birds take flight at sunset and pass over our heads, unseen in the night sky. Though these flights have been recorded for decades by the National Weather Services' network of constantly scanning weather radars, until recently these data have been mostly out of reach for bird researchers.

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ASU working to save Hawaiian coral reefs during onset of new ocean heatwave

July ended with the hottest recorded average temperature since people have been making daily readings. A huge chunk of Greenland has melted, Arctic seas have opened, and the diversity of life on Earth is threatened.

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Sundhedsstyrelsen godkender alle sundhedsaftalerne

Sundhedsstyrelsen vil følge erfaringerne med de nye sundhedsaftaler, som styrelsen netop har godkendt.

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Politisk sundhedsaftale på plads i Nordjylland: Nu skal tingene til at ske

Den nordjyske sundhedsaftale består af fem pejlemærker. Til september bliver der sat handling bag ordene, siger Per Møller (K) formand for Sundhed-, Ældre- og Handicapudvalget i Hjørring Kommune og næstformand for sundhedskoordinationsudvalget.

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Digitalt hjälpmedel halverar antalet vårddygn för hjärtsviktspatienter

Patienter med kronisk hjärtsvikt är ofta inlagda på sjukhus. Men genom att använda en läsplatta med ett särskilt program i hemmet kan antalet vårddygn minskas med drygt 50 procent.

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Researchers use epigenetics to determine the age of dolphins

Can you tell the difference between a young dolphin and an old one? Neither can scientists—not without pulling a tooth, sawing it in half and counting the growth layers like the rings of a tree.

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Researchers use epigenetics to determine the age of dolphins

Can you tell the difference between a young dolphin and an old one? Neither can scientists—not without pulling a tooth, sawing it in half and counting the growth layers like the rings of a tree.

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Træt af at læse? Din hjerne er lige så glad for lydbøger og podcasts

Hjernen aktiveres på samme måde, uanset om du læser eller hører ordene i en historie.

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The ISS Now Has Better Internet Than Most of Us After Its Latest Upgrade

submitted by /u/saiteja13427 [link] [comments]

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Germany’s Future Is Being Decided on the Left, Not the Far Right

CHEMNITZ, Germany—One year ago, violent anti-immigrant protests turned this German city near the Czech border into a worldwide symbol of racial intolerance. But on a recent summer evening, under the massive Karl Marx monument that served as a meeting point for far-right marchers back in 2018, hundreds of residents turned out to cheer on a politician with a very different message. Robert Habeck, t

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Nuclear winter would threaten nearly everyone on Earth

If the United States and Russia waged an all-out nuclear war, much of the land in the Northern Hemisphere would be below freezing in the summertime, with the growing season slashed by nearly 90 percent in some areas, according to a Rutgers-led study. Indeed, death by famine would threaten nearly all of the Earth's 7.7 billion people, said co-author Alan Robock, a Distinguished Professor in the Dep

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Parental burnout can lead to harmful outcomes for parent and child

When the daily stress of parenting becomes chronic it can turn into parental burnout, an intense exhaustion that leads parents to feel detached from their children and unsure of their parenting abilities, according to research published in Clinical Psychological Science, a journal of the Association for Psychological Science. This type of burnout can have serious consequences for both parent and c

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Scientists call for infiltration to be better incorporated into land surface models

Better simulating soil's processes helps better predict climate and land use effects

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Using artificial intelligence to track birds' dark-of-night migrations

Researchers at the University of Massachusetts Amherst and Cornell University have unveiled a machine learning system called 'MistNet' to extract bird data from the radar record and to take advantage of the treasure trove of bird migration information in the decades-long radar data archives.

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Waist size, not body mass index, may be more predictive of coronary artery disease

For years, women have been told that weight gain could lead to heart disease. A new study indicates that it is the location of the fat that matters most, with abdominal fat representing the greatest harm and not overall body mass index (BMI) when assessing risk for coronary artery disease (CAD). Results are published online today in Menopause, the journal of The North American Menopause Society (N

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What we don't know about prenatal opioid exposure

'Will the baby be OK?' In cases of prenatal opioid exposure, the answer is unclear. As part of a National Institutes of Health initiative to study the effects of a child's environment on his or her life outcomes, University of Utah developmental psychologist Elisabeth Conradt and her colleagues collected and reviewed 52 publications to identify what's known so far about how prenatal opioid exposur

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Sacklers Would Give Up Ownership of Purdue Pharma Under Settlement Proposal

The company is in discussions to resolve thousands of lawsuits. Participants in the talks value the plan at between $10 billion and $12 billion.

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Forsker: Data-profilering af arbejdsløse kan ikke både være effektiv og gennemsigtig

Det er svært at forene krav om gode spådomme med regler om gennemsigtighed og GDPR-lov, siger forsker om værktøj, som skaber dataprofiler af arbejdsløse.

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Tre dage i DSB’s gamle dieseltog giver dna-skader og nedsat lungefunktion

PLUS. De gamle ME-lokomotiver er efter planen endeligt udfaset i 2021. I mellemtiden siger DSB, at det er lykkedes at halvere antallet af ultrafine partikler.

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Altering an unhealthy gut microbiome could stave off chronic disease

New research in mice shows that turning an unhealthy microbiome into a healthy one may provide an alternative way to stave off cardiovascular disease.

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Opioid crisis: Johnson & Johnson ordered to pay $572 million

Johnson & Johnson has been ordered to pay the state of Oklahoma $572 million for downplaying the dangers and overselling the benefits of opioids. The state's lawyers argued that Johnson & Johnson had violated a public nuisance law, which concerns injuries to public health. The first federal trial in the opioid crisis is scheduled for October. It's likely that the Oklahoma verdict doesn't help dru

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Climate change is here. It's time to begin "managed retreats" according to scholars.

In a new Science article, three academics make the case for managed retreat due to climate change. Beginning the process now instead of waiting until it's too late will save money and lives. Indonesia is moving its capital from Jakarta to Borneo as the former city is sinking. None On January 23, 1973 one of the world's most active volcanoes began erupting on the Icelandic island of Heimaey. Home

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The number of new patents fighting climate change is plunging

submitted by /u/lughnasadh [link] [comments]

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UPS invests in autonomous trucking company

submitted by /u/thinkB4WeSpeak [link] [comments]

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Microplastics are found in Lake Tahoe's waters for first time ever

submitted by /u/solar-cabin [link] [comments]

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On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions [Letters (Online Only)]

We read with great interest the recent article by Kremer et al. showing that an envelope (ENV) protein encoded by human endogenous retrovirus type W (HERV-W) is present in myeloid cells in multiple sclerosis (MS) lesions, as detected by mouse monoclonal antibody GN-mAB_03 (3B2H4) directed against HERV-W ENV (1). Furthermore,…

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Reply to Ruprecht and Mayer: Unearthing genomic fossils in the pathogenesis of multiple sclerosis [Letters (Online Only)]

This Reply refers to the Letter by Ruprecht and Mayer titled “On the origin of a pathogenic HERV-W envelope protein present in multiple sclerosis lesions” (1). In their Letter, the authors confirm the specificity of the monoclonal antibody GN-MAb_03 (3B2H4) that we used to detect the pHERV-W ENV protein in…

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Take a deep breath: Multiecho fMRI denoising effectively removes head motion artifacts, obviating the need for global signal regression [Letters (Online Only)]

Power et al. (1) provide convincing evidence that multiecho independent components analysis (ME-ICA) effectively differentiates blood oxygen level-dependent (BOLD) from non-BOLD, or artifactual, signals in functional MRI (fMRI) data. Critically, ME-ICA removes spurious, distance-dependent effects caused by head motion in resting-state functional connectivity (RSFC) analyses, which have confounded

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SpaceX's Experimental Mars Rocket 'Starhopper' Just Passed Its Last Test

The company will now start testing a bigger prototype.

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'Fortnite' streaming star Ninja lands partnership with Adidas

Tyler “Ninja” Blevins, best known for being a massively popular streamer of the online video game 'Fortnite,' now has a deal with Adidas.

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E-cigarette ads may boost chance teens start vaping

Unregulated marketing of e-cigarettes may be associated with their growing popularity, according to a new study. E-cigarettes are the most popular tobacco product among teens and young adults today, surpassing cigarettes in 2014 with 4.9% of middle school students and 20.8% of high school students reportedly vaping. The study followed 2,288 teens and 2,423 young adults (ages 18-29) across metropo

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Confident conservatives beat risk-averse liberals at investing

When it comes to investing, conservatives may have a built-in advantage, according to a new study. A central tenet of long-term investing is to hold riskier investments such as stocks over holding cash or bonds, which are considered less risky. Through various studies that included more than 15,000 American adults, the researchers found that those who think like conservatives politically are more

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Johnson & Johnson’s Brand Falters Over Its Role in the Opioid Crisis

An Oklahoma court case highlights the health care giant’s role in the epidemic as a leading supplier of opioid ingredients.

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Philip Morris and Altria Are in Talks to Merge

With Altria’s investment in Juul, a combination of the tobacco giants would dominate the international market for e-cigarettes.

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Marine life is still struggling after the Deepwater Horizon oil spill

The lingering effects of the Deepwater Horizon oil spill have been extreme for deep sea creatures, with biodiversity still down years after the disaster

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Red wine benefits linked to better gut health, study finds

A study from King's College London has found that people who drank red wine had an increased gut microbiota diversity (a sign of gut health) compared to non-red wine drinkers as well as an association with lower levels of obesity and 'bad' cholesterol.

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Reply to Spreng et al.: Multiecho fMRI denoising does not remove global motion-associated respiratory signals [Letters (Online Only)]

In 2 human functional magnetic resonance imaging (fMRI) datasets (89 “ME” subjects; 12 “NA” subjects), we used signal decay properties to separate 2 kinds of signals: S0 artifacts, which were spatially specific, and T2* modulations, which occurred over the whole brain (1). We established that whole-brain (global) fMRI signals were…

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Idiosyncratic neural coding and neuromodulation of olfactory individuality in Drosophila [Neuroscience]

Innate behavioral biases and preferences can vary significantly among individuals of the same genotype. Though individuality is a fundamental property of behavior, it is not currently understood how individual differences in brain structure and physiology produce idiosyncratic behaviors. Here we present evidence for idiosyncrasy in olfactory behavior and neural responses…

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A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae [Microbiology]

Hypervirulent Klebsiella pneumoniae (hvKp) is globally disseminating as a community-acquired pathogen causing life-threatening infections in healthy individuals. The fact that a dose as little as 50 bacteria is lethal to mice illustrates the dramatic increase of virulence associated with hvKp strains compared with classical K. pneumoniae (cKp) strains, which require…

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Diverse conjugative elements silence natural transformation in Legionella species [Microbiology]

Natural transformation (i.e., the uptake of DNA and its stable integration in the chromosome) is a major mechanism of horizontal gene transfer in bacteria. Although the vast majority of bacterial genomes carry the genes involved in natural transformation, close relatives of naturally transformable species often appear not competent for natural…

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Measuring the probability of a financial crisis [Economic Sciences]

When financial firms are undercapitalized, they are vulnerable to external shocks. The natural response to such vulnerability is to reduce leverage, and this can endogenously start a financial crisis. Excessive credit growth, the main cause of financial crises, is reflected in the undercapitalization of the financial sector. Market-based measures of…

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Structural basis of Q-dependent antitermination [Biochemistry]

Lambdoid bacteriophage Q protein mediates the switch from middle to late bacteriophage gene expression by enabling RNA polymerase (RNAP) to read through transcription terminators preceding bacteriophage late genes. Q loads onto RNAP engaged in promoter-proximal pausing at a Q binding element (QBE) and adjacent sigma-dependent pause element (SDPE) to yield…

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A Rubisco-binding protein is required for normal pyrenoid number and starch sheath morphology in Chlamydomonas reinhardtii [Cell Biology]

A phase-separated, liquid-like organelle called the pyrenoid mediates CO2 fixation in the chloroplasts of nearly all eukaryotic algae. While most algae have 1 pyrenoid per chloroplast, here we describe a mutant in the model alga Chlamydomonas that has on average 10 pyrenoids per chloroplast. Characterization of the mutant leads us…

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Identifying roles for peptidergic signaling in mice [Neuroscience]

Despite accumulating evidence demonstrating the essential roles played by neuropeptides, it has proven challenging to use this information to develop therapeutic strategies. Peptidergic signaling can involve juxtacrine, paracrine, endocrine, and neuronal signaling, making it difficult to define physiologically important pathways. One of the final steps in the biosynthesis of many…

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Multiple sensory neurons mediate starvation-dependent aversive navigation in Caenorhabditis elegans [Neuroscience]

Animals demonstrate flexible behaviors through associative learning based on their experiences. Deciphering the neural mechanisms for sensing and integrating multiple types of sensory information is critical for understanding such behavioral controls. The soil nematode Caenorhabditis elegans avoids salt concentrations it has previously experienced under starvation conditions. Here, we identify a..

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Reflective prolate-spheroidal operators and the KP/KdV equations [Mathematics]

Commuting integral and differential operators connect the topics of signal processing, random matrix theory, and integrable systems. Previously, the construction of such pairs was based on direct calculation and concerned concrete special cases, leaving behind important families such as the operators associated to the rational solutions of the Korteweg–de Vries…

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Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines [Physics]

Calcium/calmodulin-dependent kinase II (CaMKII) plays a key role in the plasticity of dendritic spines. Calcium signals cause calcium−calmodulin to activate CaMKII, which leads to remodeling of the actin filament (F-actin) network in the spine. We elucidate the mechanism of the remodeling by combining computer simulations with protein array experiments and…

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Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice [Genetics]

CRISPR/Cas9-mediated genome editing technology enables researchers to efficiently generate and analyze genetically modified animals. We have taken advantage of this game-changing technology to uncover essential factors for fertility. In this study, we generated knockouts (KOs) of multiple male reproductive organ-specific genes and performed phenotypic screening of these null mutant mice…

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Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis [Immunology and Inflammation]

How pathogenic cluster of differentiation 4 (CD4) T cells in rheumatoid arthritis (RA) develop remains poorly understood. We used Nur77—a marker of T cell antigen receptor (TCR) signaling—to identify antigen-activated CD4 T cells in the SKG mouse model of autoimmune arthritis and in patients with RA. Using a fluorescent reporter…

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The nuclear receptor REV-ERB{alpha} modulates Th17 cell-mediated autoimmune disease [Immunology and Inflammation]

T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encoded by Nr1d1), a member of the nuclear hormone receptor…

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Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors [Cell Biology]

KIF1A is a kinesin family motor involved in the axonal transport of synaptic vesicle precursors (SVPs) along microtubules (MTs). In humans, more than 10 point mutations in KIF1A are associated with the motor neuron disease hereditary spastic paraplegia (SPG). However, not all of these mutations appear to inhibit the motility…

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Role of striatal {Delta}FosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates [Neuroscience]

Long-term dopamine (DA) replacement therapy in Parkinson’s disease (PD) leads to the development of abnormal involuntary movements known as l-Dopa–induced dyskinesia (LID). The transcription factor ΔFosB that is highly up-regulated in the striatum following chronic l-Dopa exposure may participate in the mechanisms of altered neuronal responses to DA generating LID….

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Mechanical stimulation activates Drosophila eggs via Trpm channels [Commentaries]

At fertilization, the terminally differentiated egg begins a new life as a totipotent zygote. Egg activation is an important process in this transformation to totipotency, as activation represents the time when immature oocytes develop from a state of cellular quiescence into one ready for embryogenesis. In PNAS, Hu and Wolfner…

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Selection on VPS13A linked to migration in a songbird [Evolution]

Animal migration demands an interconnected suite of adaptations for individuals to navigate over long distances. This trait complex is crucial for small birds whose migratory behaviors—such as directionality—are more likely innate, rather than being learned as in many longer-lived birds. Identifying causal genes has been a central goal of migration…

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Carbon-13 dynamic nuclear polarization in diamond via a microwave-free integrated cross effect [Physics]

Color-center–hosting semiconductors are emerging as promising source materials for low-field dynamic nuclear polarization (DNP) at or near room temperature, but hyperfine broadening, susceptibility to magnetic field heterogeneity, and nuclear spin relaxation induced by other paramagnetic defects set practical constraints difficult to circumvent. Here, we explore an alternate route to color-center–

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A cell-free DNA metagenomic sequencing assay that integrates the host injury response to infection [Systems Biology]

High-throughput metagenomic sequencing offers an unbiased approach to identify pathogens in clinical samples. Conventional metagenomic sequencing, however, does not integrate information about the host, which is often critical to distinguish infection from infectious disease, and to assess the severity of disease. Here, we explore the utility of high-throughput sequencing of…

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IFITM3 protects the heart during influenza virus infection [Microbiology]

Influenza virus can disseminate from the lungs to the heart in severe infections and can induce cardiac pathology, but this has been difficult to study due to a lack of small animal models. In humans, polymorphisms in the gene encoding the antiviral restriction factor IFN-induced transmembrane protein 3 (IFITM3) are…

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Ef-cd locus shortens rice maturity duration without yield penalty [Plant Biology]

The contradiction between “high yielding” and “early maturing” hampers further improvement of annual rice yield. Here we report the positional cloning of a major maturity duration regulatory gene, Early flowering-completely dominant (Ef-cd), and demonstrate that natural variation in Ef-cd could be used to overcome the above contradictory. The Ef-cd locus…

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The uric acid crystal receptor Clec12A potentiates type I interferon responses [Immunology and Inflammation]

The detection of microbes and damaged host cells by the innate immune system is essential for host defense against infection and tissue homeostasis. However, how distinct positive and negative regulatory signals from immune receptors are integrated to tailor specific responses in complex scenarios remains largely undefined. Clec12A is a myeloid…

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The expanded specificity and physiological role of a widespread N-degron recognin [Microbiology]

All cells use proteases to maintain protein homeostasis. The proteolytic systems known as the N-degron pathways recognize signals at the N terminus of proteins and bring about the degradation of these proteins. The ClpS protein enforces the N-degron pathway in bacteria and bacteria-derived organelles by targeting proteins harboring leucine, phenylalanine,…

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Generic language in scientific communication [Psychological and Cognitive Sciences]

Scientific communication poses a challenge: To clearly highlight key conclusions and implications while fully acknowledging the limitations of the evidence. Although these goals are in principle compatible, the goal of conveying complex and variable data may compete with reporting results in a digestible form that fits (increasingly) limited publication formats….

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Dynamical formation of a strongly correlated dark condensate of dipolar excitons [Physics]

Strongly interacting bosons display a rich variety of quantum phases, the study of which has so far been focused in the dilute regime, at a fixed number of particles. Here we demonstrate the formation of a dense Bose–Einstein condensate in a long-lived dark spin state of 2D dipolar excitons. A…

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Predictive shifts in free energy couple mutations to their phenotypic consequences [Biophysics and Computational Biology]

Mutation is a critical mechanism by which evolution explores the functional landscape of proteins. Despite our ability to experimentally inflict mutations at will, it remains difficult to link sequence-level perturbations to systems-level responses. Here, we present a framework centered on measuring changes in the free energy of the system to…

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Form III RubisCO-mediated transaldolase variant of the Calvin cycle in a chemolithoautotrophic bacterium [Microbiology]

The Calvin–Benson–Bassham (CBB) cycle assimilates CO2 for the primary production of organic matter in all plants and algae, as well as in some autotrophic bacteria. The key enzyme of the CBB cycle, ribulose-bisphosphate carboxylase/oxygenase (RubisCO), is a main determinant of de novo organic matter production on Earth. Of the three…

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Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration [Immunology and Inflammation]

Neutrophil migration is essential for inflammatory responses to kill pathogens; however, excessive neutrophilic inflammation also leads to tissue injury and adverse effects. To discover novel therapeutic targets that modulate neutrophil migration, we performed a neutrophil-specific microRNA (miRNA) overexpression screen in zebrafish and identified 8 miRNAs as potent suppressors of neutrophil…

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Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold [Physiology]

Ambient temperature influences the molecular clock and lipid metabolism, but the impact of chronic cold exposure on circadian lipid metabolism in thermogenic brown adipose tissue (BAT) has not been studied. Here we show that during chronic cold exposure (1 wk at 4 °C), genes controlling de novo lipogenesis (DNL) including…

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Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus [Immunology and Inflammation]

Excessive self-reactive and inadequate affinity-matured antigen-specific antibody responses have been reported to coexist in lupus, with elusive cellular and molecular mechanisms. Here, we report that the antigen-specific germinal center (GC) response―a process critical for antibody affinity maturation―is compromised in murine lupus models. Importantly, this defect can be triggered by excessive…

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Human cytomegalovirus induces and exploits Roquin to counteract the IRF1-mediated antiviral state [Microbiology]

RNA represents a pivotal component of host–pathogen interactions. Human cytomegalovirus (HCMV) infection causes extensive alteration in host RNA metabolism, but the functional relationship between the virus and cellular RNA processing remains largely unknown. Through loss-of-function screening, we show that HCMV requires multiple RNA-processing machineries for efficient viral lytic production. In.

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Large-scale identification and functional analysis of NLR genes in blast resistance in the Tetep rice genome sequence [Genetics]

Tetep is a rice cultivar known for broad-spectrum resistance to blast, a devastating fungal disease. The molecular basis for its broad-spectrum resistance is still poorly understood. Is it because Tetep has many more NLR genes than other cultivars? Or does Tetep possess multiple major NLR genes that can individually confer…

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Recurrent convergent evolution at amino acid residue 261 in fish rhodopsin [Evolution]

The evolutionary process that occurs when a species colonizes a new environment provides an opportunity to explore the mechanisms underlying genetic adaptation, which is essential knowledge for understanding evolution and the maintenance of biodiversity. Atlantic herring has an estimated total breeding stock of about 1 trillion (1012) and has colonized…

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Encounter complexes and hidden poses of kinase-inhibitor binding on the free-energy landscape [Biophysics and Computational Biology]

Modern drug discovery increasingly focuses on the drug-target binding kinetics which depend on drug (un)binding pathways. The conventional molecular dynamics simulation can observe only a few binding events even using the fastest supercomputer. Here, we develop 2D gREST/REUS simulation with enhanced flexibility of the ligand and the protein binding site….

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Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines [Genetics]

Telomerase is pathologically reactivated in most human cancers, where it maintains chromosomal telomeres and allows immortalization. Because telomerase reverse transcriptase (TERT) is usually the limiting component for telomerase activation, numerous studies have measured TERT mRNA levels in populations of cells or in tissues. In comparison, little is known about TERT…

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Activity-based ratiometric FRET probe reveals oncogene-driven changes in labile copper pools induced by altered glutathione metabolism [Chemistry]

Copper is essential for life, and beyond its well-established ability to serve as a tightly bound, redox-active active site cofactor for enzyme function, emerging data suggest that cellular copper also exists in labile pools, defined as loosely bound to low-molecular-weight ligands, which can regulate diverse transition metal signaling processes spanning…

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Prenatal exposure to organophosphate pesticides and functional neuroimaging in adolescents living in proximity to pesticide application [Psychological and Cognitive Sciences]

We have reported consistent associations of prenatal organophosphate pesticide (OP) exposure with poorer cognitive function and behavior problems in our Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS), a birth cohort of Mexican American youth in California’s agricultural Salinas Valley. However, there is little evidence on…

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Human pollution exposure correlates with accelerated ultrastructural degradation of hair fibers [Biophysics and Computational Biology]

Exposure to pollution is a known risk factor for human health. While correlative studies between exposure to pollutants such as polycyclic aromatic hydrocarbons (PAHs) and human health exist, and while in vitro studies help to establish a causative connection, in vivo comparisons of exposed and nonexposed human tissue are scarce….

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Editorial Expression of Concern: Nanospherical arabinogalactan proteins are a key component of the high-strength adhesive secreted by English ivy [Editorial Expressions of Concern]

ENGINEERING PNAS is publishing an Editorial Expression of Concern regarding the following article: “Nanospherical arabinogalactan proteins are a key component of the high-strength adhesive secreted by English ivy,” by Yujian Huang, Yongzhong Wang, Li Tan, Leming Sun, Jennifer Petrosino, Mei-Zhen Cui, Feng Hao, and Mingjun Zhang, which was first published…

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In vivo evidence for a regulatory role of phosphorylation of Arabidopsis Rubisco activase at the Thr78 site [Plant Biology]

Arabidopsis Rubisco activase (Rca) is phosphorylated at threonine-78 (Thr78) in low light and in the dark, suggesting a potential regulatory role in photosynthesis, but this has not been directly tested. To do so, we transformed an rca-knockdown mutant largely lacking redox regulation with wild-type Rca-β or Rca-β with Thr78-to-Ala (T78A)…

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Mosquito bite prevention through graphene barrier layers [Engineering]

Graphene-based materials are being developed for a variety of wearable technologies to provide advanced functions that include sensing; temperature regulation; chemical, mechanical, or radiative protection; or energy storage. We hypothesized that graphene films may also offer an additional unanticipated function: mosquito bite protection for light, fiber-based fabrics. Here, we investigate…

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Spontaneous generation of hydrogen peroxide from aqueous microdroplets [Chemistry]

We show H2O2 is spontaneously produced from pure water by atomizing bulk water into microdroplets (1 μm to 20 µm in diameter). Production of H2O2, as assayed by H2O2-sensitve fluorescence dye peroxyfluor-1, increased with decreasing microdroplet size. Cleavage of 4-carboxyphenylboronic acid and conversion of phenylboronic acid to phenols in microdroplets…

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Allosteric modulation of {beta}-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice [Pharmacology]

Given the global epidemic in type 2 diabetes, novel antidiabetic drugs with increased efficacy and reduced side effects are urgently needed. Previous work has shown that M3 muscarinic acetylcholine (ACh) receptors (M3Rs) expressed by pancreatic β cells play key roles in stimulating insulin secretion and maintaining physiological blood glucose levels….

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LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells [Biophysics and Computational Biology]

The perception of sound relies on sensory hair cells in the cochlea that convert the mechanical energy of sound into release of glutamate onto postsynaptic auditory nerve fibers. The hair cell receptor potential regulates the strength of synaptic transmission and is shaped by a variety of voltage-dependent conductances. Among these…

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Optimism is associated with exceptional longevity in 2 epidemiologic cohorts of men and women [Medical Sciences]

Most research on exceptional longevity has investigated biomedical factors associated with survival, but recent work suggests nonbiological factors are also important. Thus, we tested whether higher optimism was associated with longer life span and greater likelihood of exceptional longevity. Data are from 2 cohorts, women from the Nurses’ Health Study…

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Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly [Neuroscience]

Giant ankyrin-G (gAnkG) coordinates assembly of axon initial segments (AISs), which are sites of action potential generation located in proximal axons of most vertebrate neurons. Here, we identify a mechanism required for normal neural development in humans that ensures ordered recruitment of gAnkG and β4-spectrin to the AIS. We identified…

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Hopanoid lipids may facilitate aerobic nitrogen fixation in the ocean [Environmental Sciences]

Cyanobacterial diazotrophs are considered to be the most important source of fixed N2 in the open ocean. Biological N2 fixation is catalyzed by the extremely O2-sensitive nitrogenase enzyme. In cyanobacteria without specialized N2-fixing cells (heterocysts), mechanisms such as decoupling photosynthesis from N2 fixation in space or time are involved in…

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Efficient genome-wide first-generation phenotypic screening system in mice using the piggyBac transposon [Genetics]

Genome-wide phenotypic screens provide an unbiased way to identify genes involved in particular biological traits, and have been widely used in lower model organisms. However, cost and time have limited the utility of such screens to address biological and disease questions in mammals. Here we report a highly efficient piggyBac…

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Chemoptogenetic damage to mitochondria causes rapid telomere dysfunction [Cell Biology]

Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer. Mitochondria are an important source of ROS; however, the spatiotemporal ROS events underlying oxidative cellular damage from dysfunctional mitochondria remain unresolved. To this end, we have developed and validated a chemoptogenetic approach that uses a mitochondrially targeted fluorogen-activating…

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Correction for Tananbaum et al., Riccardo Giacconi (1931-2018) [Corrections]

RETROSPECTIVE Correction for “Riccardo Giacconi (1931–2018),” by Harvey Tananbaum, Ethan J. Schreier, and Wallace Tucker, which was first published June 4, 2019; 10.1073/pnas.1902399116 (Proc. Natl. Acad. Sci. U.S.A. 116, 12587–12589). The authors note that on page 12587, right column, first full paragraph, line 4, “June 12, 1962” should instead appear…

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The GABA receptor GABRR1 is expressed on and functional in hematopoietic stem cells and megakaryocyte progenitors [Cell Biology]

GABRR1 is a rho subunit receptor of GABA, the major inhibitory neurotransmitter in the mammalian brain. While most investigations of its function focused on the nervous system, its regulatory role in hematopoiesis has not been reported. In this study, we found GABRR1 is mainly expressed on subsets of human and…

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Gold nanoshell-localized photothermal ablation of prostate tumors in a clinical pilot device study [Medical Sciences]

Biocompatible gold nanoparticles designed to absorb light at wavelengths of high tissue transparency have been of particular interest for biomedical applications. The ability of such nanoparticles to convert absorbed near-infrared light to heat and induce highly localized hyperthermia has been shown to be highly effective for photothermal cancer therapy, resulting…

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Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors [Immunology and Inflammation]

Deletion or Treg cell differentiation are alternative fates of autoreactive MHCII-restricted thymocytes. How these different modes of tolerance determine the size and composition of polyclonal cohorts of autoreactive T cells with shared specificity is poorly understood. We addressed how tolerance to a naturally expressed autoantigen of the central nervous system…

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Metamaterial architecture from a self-shaping carnivorous plant [Biophysics and Computational Biology]

As meticulously observed and recorded by Darwin, the leaves of the carnivorous plant Drosera capensis L. slowly fold around insects trapped on their sticky surface in order to ensure their digestion. While the biochemical signaling driving leaf closure has been associated with plant growth hormones, how mechanical forces actuate the…

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The joint influence of intelligence and practice on skill development throughout the life span [Psychological and Cognitive Sciences]

The relative importance of different factors in the development of human skills has been extensively discussed. Research on expertise indicates that focused practice may be the sole determinant of skill, while intelligence researchers underline the relative importance of abilities at even the highest level of skill. There is indeed a…

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Endogenous fluctuations in the dopaminergic midbrain drive behavioral choice variability [Psychological and Cognitive Sciences]

Human behavior is surprisingly variable, even when facing the same problem under identical circumstances. A prominent example is risky decision making. Economic theories struggle to explain why humans are so inconsistent. Resting-state studies suggest that ongoing endogenous fluctuations in brain activity can influence low-level perceptual and motor processes, but it…

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Positive selection in dNTPase SAMHD1 throughout mammalian evolution [Microbiology]

The vertebrate protein SAMHD1 is highly unusual in having roles in cellular metabolic regulation, antiviral restriction, and regulation of innate immunity. Its deoxynucleoside triphosphohydrolase activity regulates cellular dNTP concentration, reducing levels below those required by lentiviruses and other viruses to replicate. To counter this threat, some primate lentiviruses encode accessory…

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Therapeutic genome editing of triple-negative breast tumors using a noncationic and deformable nanolipogel [Engineering]

Triple-negative breast cancer (TNBC), which has the highest mortality rate of all breast cancer, is in urgent need of a therapeutic that hinders the spread and growth of cancer cells. CRISPR genome editing holds the promise of a potential cure for many genetic diseases, including TNBC; however, its clinical translation…

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Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling [Developmental Biology]

The adult mammalian heart has limited capacity for regeneration following injury, whereas the neonatal heart can readily regenerate within a short period after birth. To uncover the molecular mechanisms underlying neonatal heart regeneration, we compared the transcriptomes and epigenomes of regenerative and nonregenerative mouse hearts over a 7-d time period…

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Human-modified landscapes alter mammal resource and habitat use and trophic structure [Ecology]

The broad negative consequences of habitat degradation on biodiversity have been studied, but the complex effects of natural–agricultural landscape matrices remain poorly understood. Here we used stable carbon and nitrogen isotopes to detect changes in mammal resource and habitat use and trophic structure between preserved areas and human-modified landscapes (HMLs)…

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Watch StarHopper successfully tested by SpaceX with 150 meter hop.

submitted by /u/MontanaLabrador [link] [comments]

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StarHopper is about to launch! Come watch it live!

submitted by /u/FutureVisionPodcast [link] [comments]

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6D.ai aims to build a 3D map of the world using only smartphone cameras

submitted by /u/QuantumThinkology [link] [comments]

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Author Correction: A nano-mechanical instability as primary contribution to rolling resistance

Scientific Reports, Published online: 28 August 2019; doi:10.1038/s41598-019-48628-w

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Author Correction: Fingolimod-induced decrease in heart rate may predict subsequent decreasing degree of lymphocytes

Scientific Reports, Published online: 28 August 2019; doi:10.1038/s41598-019-48630-2

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Author Correction: Earth tectonics as seen by GOCE – Enhanced satellite gravity gradient imaging

Scientific Reports, Published online: 28 August 2019; doi:10.1038/s41598-019-48629-9

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Author Correction: Adenovirus-mediated suppression of hypothalamic glucokinase affects feeding behavior

Scientific Reports, Published online: 28 August 2019; doi:10.1038/s41598-019-48627-x

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The Atlantic Politics & Policy Daily: Bill and Joe’s Excellent Adventure

Were you forwarded this email? Sign yourself up here. We have many other free email newsletters on a variety of other topics. Browse the full list. What We’re Following Today It’s Tuesday, August 27. ‣ A federal judge blocked Missouri’s ban on abortions after eight weeks (the ban had been set to take place tomorrow). ‣ Tropical Storm Dorian is on the edge of hurricane status as it heads toward Pu

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Concentrated cannabis is much stronger than weed and it's gaining popularity—especially with teens

Nearly a quarter of all eighth, tenth, and twelfth grade students surveyed in Arizona had used cannabis concentrate at one point. The product has as much as three times the THC as marijuana. (Pixabay/) Recreational marijuana was legalized in Washington state in 2012, and saw over 44 million individual purchases of the drug by 2017. Typical cannabis flowers made up the bulk of those sales—but cann

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Is setting a deadline for eradicating malaria a good idea? Scientists are divided

Two upcoming reports disagree on the wisdom of setting 2050 goal for ending the disease

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IPCC's land report showed we're entering an era of damage control

The IPCC has published a new report on climate and land . The report includes chapters on land-climate interactions (land use changes are accelerating global warming, which is causing more extreme weather), desertification (deserts are expanding), land degradation (declining quality of soil, for example), and food security. The latter is a particularly critical topic, given our dependence on food

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Water harvester makes it easy to quench your thirst in the desert

In 2017, chemists demonstrated that a new MOF design could rapidly adsorb water from even dry air, allowing it to be condensed and collected for drinking. A second-generation MOF can now cycle through adsorption and desorption in 20 minutes, allowing continuous collection of more than a liter per day per kilogram of MOF using solar power. The new MOF is the basis of a planned microwave-sized devic

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Vaccine against deadly superbug Klebsiella effective in mice

Researchers have developed a vaccine that is effective, in mice, against hypervirulent strains of Klebsiella that can cause life-threatening infections in healthy adults.

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What Is HPV?

Most sexually active men and women will contract HPV at some point in their lives. So, yes, you should probably get the vaccine.

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A Hack to Steal a Tesla, a Yelp Overhaul, and More News

Catch up on the most important news from today in two minutes or less.

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New in the Hastings Center Report, July-August 2019

Bystander ethics and good samaritanism, the 'grueling carousel' of caring for a homeless patient during her 30th admission, quandaries of egg freezing, and more in the latest issue.

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Sea snail goo could help prevent colon cancer, study shows

The Australian sea snail secretes a purple goo that protects its eggs from the bacteria-rich marine environment. This goo contains a compound that appears to be remarkably effective at preventing colon cancer in mice. The ocean is a vast resource for potential cancer treatments, though it remains mostly untapped. None A purple goo that the Australian sea snail produces to protect its eggs contain

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Top-rated backpacks for a weekend outside

Packs that lead the pack. (Fabrizio Verrecchia via Unsplash/) Choosing a backpack for your next outdoor adventure is no easy task. With dozens of options available, narrowing down the best pack for you can take some serious research. What it really comes down to are the features that will be most important to you, based on the type of outdoor weekend you’re planning. If you’ll be doing a fast-pac

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Shock and thaw? Earth’s oldest asteroid impact may have helped lift the planet out of a deep freeze

Researchers say 2.23-billion-year-old Yarrabubba impact vaporized ice sheets, creating a steamy greenhouse

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These Researchers Want to Run a Cable From the Earth to the Moon

It would be much easier to escape Earth’s gravity if you could skip the energy-intensive rockets. That’s the idea behind the Spaceline, a newly-proposed type of space elevator that would link the Earth and the Moon in a bid drastically cut the cost of space travel. Described in research published to the preprint server ArXiv by researchers at Columbia University and Cambridge University, the Spac

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Vaccine against deadly superbug Klebsiella effective in mice

Researchers at Washington University School of Medicine in St. Louis and the biotech startup VaxNewMo have developed a vaccine that is effective, in mice, against hypervirulent strains of Klebsiella that can cause life-threatening infections in healthy adults.

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High-tech hiking socks to keep your feet dry

Best hiking socks for a long trek. (Nathan Dumlao via Unsplash/) Regular cotton socks won’t cut it when you’re going on long hikes or camping trips. Sweaty, wet feet lead to blisters, chafing, and irritation. Blisters, while banal, can immobilize you on the trail, so you need socks that can protect your feet, keep them dry, and last through many long days. Naturally wicking and odor absorbent mer

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Futurist Predicts Cyborgs Will Replace Humans on Earth

Step Aside When British futurist James Lovelock looks to the future, he doesn’t see humans ruling the Earth. “Our supremacy as the prime understanders of the cosmos is rapidly coming to end,” he wrote in his new book “Novacene,” according to NBC News . “The understanders of the future will not be humans but what I choose to call ‘cyborgs’ that will have designed and built themselves.” The Novacen

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Gold nanoparticles shown to be safe and effective treatment for prostate cancer

Bio-compatible gold nanoparticles designed to convert near-infrared light to heat have been shown to safely and effectively ablate low- to intermediate-grade tumors within the prostate, according to a new study.

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What on Earth Is Water Doing in Hawaii's Kilauea Volcano?

WIRED sits down with a geologist to learn how scientists might sample the newfound water—and why you shouldn’t panic and cancel your island getaway.

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A New Japanese Stem Cell Treatment Raises Hopes — And Ethical Questions

Stemirac is arguably the world’s most ambitious approved stem cell treatment and should have been a cause for celebration: a long-awaited breakthrough using modern biological tools to repair the body and a harbinger of more impressive medicines. Instead, the therapy has been met with heated debate.

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Water harvester makes it easy to quench your thirst in the desert

In 2017, UC Berkeley chemists demonstrated that a new MOF design could rapidly adsorb water from even dry air, allowing it to be condensed and collected for drinking. A second-generation MOF can now cycle through adsorption and desorption in 20 minutes, allowing continous collection of more than a liter per day per kilogram of MOF using solar power. The new MOF is the basis of a planned microwave-

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Electric foot massagers you probably deserve

After a long day on your feet, give your paws a bit of love. (Brina Blum via Unsplash/) We hold an immense amount of stress in our feet. Whether your job requires you to stand for hours on end or you suffer from chronic foot pain, the right electric foot massager can provide relief. Had a hard day at work and/or waiting in line at Disneyland? Kick off your shoes, pour a glass of wine, and turn on

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Lunch boxes that'll get you excited about leftovers

Clutch containers for your food. (Ella Olsson via Unsplash/) The midday meal should be a chance to relax and take your mind off of work for a little while. But when you order delivery or grab takeout, botched orders and long wait times can actually make your break more stressful. Bring exactly what you want, however you want it, with one of these stylish and functional lunch containers. Built to

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NASA Has Fired Up the Deep Space Atomic Clock

NASA has to rethink some tried-and-true approaches to spacecraft navigation as it eyes more distant targets. Spacecraft need extremely accurate location measurements to plan maneuvers, but the way we’ve been doing that can be painfully slow. That’s why NASA launched a new prototype atomic clock into orbit recently. This device could revolutionize space exploration, and the team just turned it on

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Microplastics are found in Lake Tahoe's waters for first time ever

Scientists have detected microplastic pollution in Lake Tahoe's deep blue waters for the first time. Now they are trying to determine its source and potential harm to the lake's flora and fauna.

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Scientists Say You Should Feed Insects to Your Dog or Cat

Worm Food Pet owners could soon trade in chicken and beef cat and dog foods for ones made from insects — a move that experts say could benefit both the environment and humanity. “There’s a really exciting future for the use of insect protein for companion animals,” Simon Doherty, president of the British Veterinary Association, told BBC News . “It’s a fantastic opportunity — looking at insects to

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Ny metode afslører om din kartoffel er økologisk eller ej

Forskere fra Københavns Universitet har udviklet en ny metode som skal hjælpe myndigheder og…

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NASA dangles $7 billion carrot for next moon landing

The agency that sent humans to the moon 50 years ago is offering $7 billion to take the first steps for a U.S. return to the lunar surface within five years.

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Amelia Earhart Expedition Ends With Potential Clues, but No Answers

Amelia Earhart standing in front of the Lockheed Electra in which she disappeared in July 1937. Born in Atchison, Kansas in 1897, Amelia Earhart did not begin flying until after her move to California in 1920. After taking lessons from aviation pioneer Neta Snook in a Curtiss Jenny, Earhart set out to break flying records, breaking the women altitude records in 1922. Earhart continually promoted

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Destructive Amazon Fires Do Not Threaten Earth's Oxygen, Expert Says

There is enough oxygen in the air to last for millions of years — Read more on ScientificAmerican.com

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Nuking hurricanes out of the sky 'doesn't make sense at all'

Can we hit them before they hit us? (NASA/) Every year, a handful of the wet weather events in the tropics swell into hurricanes . These monster storms crash into coastlines and can inflict billions of dollars of damage , earning their reputation as some of nature's scariest disasters. They have the potential to kill thousands and wreak ongoing environmental and economic chaos. So why not try to

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Who owns the brains in Moscow, Amunts lawyer’s version

Katrin Amunts and University of Düsseldorf deploy lawyers to silence whistleblowers. After I was threatened with lawsuit, this post replaces the previous one. Learn the truth of who owns the brains in Moscow.

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Brazil farmers deforesting Amazon 'to survive'

On his block of land deep in the Amazon rainforest, Aurelio Andrade says deforestation is the only way he and other farmers can survive in the remote region where fires are raging.

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Hackers Could Steal a Tesla Model S by Cloning Its Key Fob—Again

The same researchers who figured out how to clone a Tesla Model S key fob have done it again, cracking the replacement that was meant to fix the problem.

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Novel therapy studied for inherited breast cancer

Adding back a tiny molecule, microRNA 223-3p, to BRCA1-mutant cancer cells forces the cancer to die, researchers discovered. BRCA1-mutant cancer is the type of inherited cancer for which Angelina Jolie had preventive surgery in 2013.

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Enhancing materials for hi-res patterning to advance microelectronics

Scientists created organic-inorganic materials for transferring ultrasmall features into silicon with a high aspect ratio.

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Neurological brain markers might detect risk for psychotic disorders

People who may hear and see things that are not there could have symptoms of psychosis, better known as psychotic disorders. Now, researchers have found neurological markers in the human brain that can be used to detect people at-risk for developing psychotic disorders and to understand when this risk has been successfully treated.

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Using Wi-Fi like sonar to measure speed and distance of indoor movement

Researchers have developed a technique for measuring speed and distance in indoor environments, which could be used to improve navigation technologies for robots, drones — or pedestrians trying to find their way around an airport. The technique uses a novel combination of Wi-Fi signals and accelerometer technology to track devices in near-real time.

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Better seizure control with ketogenic diet in infants with genetic epilepsy

Research shows that starting infants as young as 3 weeks old on the ketogenic diet is effective in treating epilepsy.

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Social media stress can lead to social media addiction

Social network users risk becoming more and more addicted to social media platforms even as they experience stress from their use. Research into the habits of 444 Facebook users revealed they would switch between activities such as chatting to friends, scanning news feeds and posting updates as each began to cause stress. This leads to an increased likelihood of technology addiction, as they use t

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How plants decide between growth or defense

During their daily quest for survival, plants need to strike a careful balance between growth and defence. Both functions are vital for their successful reproduction, however, most plants are not able to do both at the same time. The mechanisms behind this peculiar trade-off are little understood and it has often been hypothesised that restricted energy availability is the main limiting cause.

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Healthy habits ward off dementia — for select seniors

Nature, Published online: 27 August 2019; doi:10.1038/d41586-019-02555-y For a fortunate group, exercise and the right diet could protect against cognitive symptoms that develop with age.

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The World's First Space Crime May Have Occurred on the International Space Station Last Year

What happens when an alleged crime occurs in space? It starts with an investigation on Earth.

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Big Think Edge: Learn 3 new skills this week

In this week's trio of Big Think Edge videos, it's all about mastery, whether you want to be a master explainer, master presenter, or a master problem-solver. A great explanation can only come from a deep understanding of your topic, says Mihir Desai. Want your slide shows to excel? Nancy Duarte's got your strategy. That mind-boggling problem won't be so impossible to resolve once you distill it

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Ex-Uber Engineer Levandowski Charged With Trade-Secret Theft

Prosecutors say Anthony Levandowski took drawings and designs for self-driving technology from Google to Uber in 2016.

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The Middle East is already a cyberwar hotbed. Things just got worse.

A hacking group with links to Iran is the latest threat that makes the Persian Gulf one of the world’s most active theaters of cyberwar.

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Family-school engagement has specific perks for young students

Both elementary school children and middle school children are less likely to have concentration problems and behavioral issues at the end of a school year if their parents made a greater effort to be engaged with their schooling earlier in the year.

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Positives of climate change? Agricultural, economic possibilities for West Virginia

Researchers found that, between 1900 and 2016, maximum temperatures in West Virginia trended downward, average minimum temperatures ascended and annual precipitation increased. Even so, he predicts future climates in West Virginia will be more conducive to agricultural production.

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Astronomers find a golden glow from a distant stellar collision

Astronomers have re-examined data from a gamma-ray burst spotted in August 2016 and found new evidence for a kilonova — a turbocharged explosion that instantly forged several hundred planets' worth of gold and platinum.

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Computational approach speeds up advanced microscopy imaging

Researchers have developed a way to enhance the imaging speed of two-photon microscopy up to 5 times without compromising resolution. This record-fast imaging speed will allow scientists to observe biological phenomena that were previously too fleeting to image with current state-of-the-art advanced microscopy.

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The Amazon Is Not Earth’s Lungs

As tongues of flame lapped the planet’s largest tract of rain forest over the past few weeks, it has rightfully inspired the world’s horror. The entire Amazon could be nearing the edge of a desiccating feedback loop, one that could end in catastrophic collapse . This collapse would threaten millions of species, from every branch of the tree of life, each of them—its idiosyncratic splendor, its su

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Weird illusion makes you think fabric is moving faster than it is

Your skin is terrible at judging how fast different textured materials are moving, highlighting a strange quirk in how the brain encodes touch

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Børn rører sig for lidt: Her er spillene, der får dig op af sofaen

Børn mellem 11 og 15 bruger for meget tid bag skærmene, skriver Sundhedsstyrelsen.

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Researchers create breathalyzer that can detect marijuana

submitted by /u/QuantumThinkology [link] [comments]

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Researchers engineer antibodies that unlock body's regenerative potential

submitted by /u/QuantumThinkology [link] [comments]

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Global trade in baby elephants for zoos banned

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China Power figures show how much cheaper solar is than coal

submitted by /u/V2O5 [link] [comments]

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Computational approach speeds up advanced microscopy imaging

Researchers have developed a way to enhance the imaging speed of two-photon microscopy up to 5 times without compromising resolution. This record-fast imaging speed will allow scientists to observe biological phenomena that were previously too fleeting to image with current state-of-the-art advanced microscopy.

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AI Turned These Emojis Into Photorealistic Monstrosities

Artificial intelligence is really good at generating images of the human face — something algorithms can learn to do after studying thousands and thousands of headshots . That’s how we end up with AI-reconstructed portraits , stylistic AI-generated caricatures and anime portraits , and believable images of people who never actually existed. The latest iteration of this trend comes in the form of

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Social-Media Companies ‘Threaten Democracy’

Today social-media companies such as Facebook and Twitter are the gatekeepers of meaningful freedom of speech. This is problematic, the New York Law School professor Nadine Strossen argues, because these companies often self-regulate in ways that violate the First Amendment.

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A Glowing Clue in the Search for Alien Life

It takes more than four years for its light to reach us, but Proxima Centauri is one of our closest neighbors. The star orbits in the constellation Centaurus, visible in the Southern Hemisphere, but is itself too faint to see with the naked eye. Proxima isn’t like our sun; it is smaller, dimmer, and cooler. These suns are prone to frequent flares of ultraviolet radiation, which can be bad news fo

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New info on regulation of sense of smell with the help of nematodes

PIM kinases are enzymes that are evolutionarily well conserved in both humans and nematodes. The group has previously proven that PIM kinases promote the motility and survival of cancer cells, but now the group has shown that these enzymes also regulate the sense of smell.

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Jeffrey Epstein's influence in the science world is a symptom of larger problems | Kate Darling

In a system stacked against women, we must direct our harshest judgment at people and institutions who remain silent Many of us are reeling from the recent news that MIT’s Media Lab, where I work as a researcher, took funding from Jeffrey Epstein, the late financier who faced federal sex-trafficking charges. For me, the Epstein connections don’t stop there: Epstein had close ties to John Brockman

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Enhancing materials for hi-res patterning to advance microelectronics

Scientists created organic-inorganic materials for transferring ultrasmall features into silicon with a high aspect ratio.

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Novel therapy studied for inherited breast cancer

Adding back a tiny molecule, microRNA 223-3p, to BRCA1-mutant cancer cells forces the cancer to die, researchers at UT Health San Antonio discovered. BRCA1-mutant cancer is the type of inherited cancer for which Angelina Jolie had preventive surgery in 2013.

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'Vagina Bible' Tackles Health And Politics In A Guide To Female Physiology

Frustrated with online marketing sites that peddle needless "health aids" and fears, gynecologist and columnist Jen Gunter aims to dispel myths about the female body and restore power to patients. (Image credit: Meredith Rizzo/NPR)

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Mysterious Illness Linked to Lychees Kills Children in India

Malnourished kids who eat the fruit containing a naturally occurring toxin suffer from low blood sugar and symptoms of encephalopathy.

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DEA Announces Plan to Expand Researchers’ Access to Marijuana

The Drug Enforcement Administration is finally ready to make good on its promise to let more researchers grow marijuana — and patients across the nation could benefit from it. In 1968, the U.S. government agreed to let scientists at the University of Mississippi grow marijuana for research purposes. To this day, it’s still the only facility with such approval — which means, weirdly, that every si

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Surfing Teahupo‘o, as Seen From Above and Below

The 2019 Tahiti Pro, stop No. 7 of the World Surf League Men’s Championship Tour, is under way this week in Tahiti. Brian Bielmann, a photographer with Agence France-Presse, is on the scene, capturing images of the surfers amid the beauty and chaos churned up by the famous waves of Teahupo‘o reef. Collected below, some of Bielmann’s photos of practice sessions and competition runs, as seen from t

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Nanoparticles let cancer ‘leak’ from blood vessels. Is this a fix?

Scientists have discovered a control mechanism that regulates the traffic of cells and substances across blood vessels, which can affect cancer metastasis. Nanoparticles play a role in various biomedical applications, including the diagnosis and treatment of cancer. Drug releasing nanoparticles could be programmed to deliver drugs locally at the tumor site. However, recent studies have shown that

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Using Wi-Fi like sonar to measure speed and distance of indoor movement

Researchers have developed a technique for measuring speed and distance in indoor environments, which could be used to improve navigation technologies for robots, drones — or pedestrians trying to find their way around an airport. The technique uses a novel combination of Wi-Fi signals and accelerometer technology to track devices in near-real time.

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More Scientists, Institutions with Links to Jeffrey Epstein

Researchers continued to meet and accept funding from the wealthy donor even after he was convicted of sex crimes in 2008.

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Brain MRIs may reveal psychotic disorder risk

Neurological markers in the brain can help detect people at risk of developing psychotic disorders and indicate when this risk has been successfully treated, researchers say. People who may hear and see things that are not there could have symptoms of psychosis, better known as psychotic disorders. “Psychotic disorders like schizophrenia are often lifelong and disabling for individuals,” says Joh

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A.I. makes nylon production way more sustainable

A new method could make producing the precursor to nylon much more environmentally friendly, researchers report. The chemical and allied industries face challenges such as ready access to reliable energy supplies, waste reduction, water conservation, and energy efficiency. Organic electrosynthesis—an electricity-driven, energy-efficient process that can easily integrate with renewable energy sour

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Man Has 25% of His Skin Removed to Treat 'Flesh-Eating' Infection

A man in Florida has lost 25% of his skin after developing a life-threatening infection with flesh-eating bacteria.

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Puerto Rico mobilizes as potential hurricane approaches

Puerto Rico has mobilized thousands of federal agents ahead of what threatens to be the first hurricane to lash the US territory since it was ravaged by Maria in 2017, authorities said Tuesday.

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ZIKV infection induces robust Th1-like Tfh cell and long-term protective antibody responses in immunocompetent mice

Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11754-0 Here, the authors show that Zika virus (ZIKV) infection induces Th1-like Tfh cells that depend on T-bet for their development and are essential for class switching of ZIKV-specific IgG2c antibodies and maintenance of long-term neutralizing antibody responses.

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Dispersion relation of the collective excitations in a resonantly driven polariton fluid

Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11886-3 Owing to its driven-dissipative nature, and its solid-state environment, a resonantly driven polariton condensate can be accompanied by an incoherent reservoir of excitons. Stepanov et al. demonstrate that this situation strongly modifies the spectrum of collective excitations, which determines many quantum hy

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Micro-/nano-voids guided two-stage film cracking on bioinspired assemblies for high-performance electronics

Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11803-8 Metal film-based electronics usually fail via uncontrolled cracking at small strains. Here, the authors design a micro-/nano-structured surface with bundled flexible nanowires onto which a metal film can stretch more than a regular flat surface, retard penetrating cracks and remain sensitive.

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Highly active ruthenium metathesis catalysts enabling ring-opening metathesis polymerization of cyclopentadiene at low temperatures

Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11806-5 Due to the low ring strain and facile dimerization, ring-opening metathesis polymerization of cyclopentadiene, readily obtainable from petroleum feedstock, has not been realized. Here the authors show an ultrarapidly initiating trifluoromethanesulfonamide-based ruthenium catalyst enables it at low temperatures

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Priming mobilization of hair follicle stem cells triggers permanent loss of regeneration after alkylating chemotherapy

Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11665-0 Hair follicles (HFs) are sensitive to chemotherapy but recover from quiescent HF stem cells, although sometimes chemotherapy results in permanent loss. Here, Kim et al. establish a model of permanent chemotherapy-induced alopecia to uncover the underlying mechanisms depleting human HF stem cells.

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A stable zirconium based metal-organic framework for specific recognition of representative polychlorinated dibenzo-p-dioxin molecules

Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11912-4 The sensing of polychlorinated dibenzo-p-dioxins (PCDDs) is important for the environment and public health but challenging to achieve. Here the authors report a stable zirconium-based metal-organic framework for the selective sensing of two representative PCCDs based on the fluorescence quenching method.

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A short comment on statistical versus mathematical modelling

Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11865-8 While the crisis of statistics has made it to the headlines, that of mathematical modelling hasn’t. Something can be learned comparing the two, and looking at other instances of production of numbers.Sociology of quantification and post-normal science can help.

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Structure of a bound peptide phosphonate reveals the mechanism of nocardicin bifunctional thioesterase epimerase-hydrolase half-reactions

Nature Communications, Published online: 27 August 2019; doi:10.1038/s41467-019-11740-6 NocTE is a nonribosomal peptide synthetase thioesterase that completes the biosynthesis of pro-nocardicin G, the precursor for nocardicin β-lactam antibiotics. Here the authors provide mechanistic insights into NocTE by determining its crystal structures in the ligand-free form and covalently linked to a fluor

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Neurological brain markers might detect risk for psychotic disorders

People who may hear and see things that are not there could have symptoms of psychosis, better known as psychotic disorders. Now, researchers at the University of Missouri have found neurological markers in the human brain that can be used to detect people at-risk for developing psychotic disorders and to understand when this risk has been successfully treated.

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Turbocharging the body's natural killer cells to defeat cancer

Natural Killer (NK) cells have long been the soldiers of the immune system that prevents the growth and spread of cancers, and subduing this army of cells is one of the key ways that tumours take hold. Researchers have discovered a protein that prevents NK cells from doing their job fighting cancer. Importantly the study reveals that blocking this protein turbo charges the immune system to fight o

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How texture deceives the moving finger

The perceived speed of a surface moving across the skin depends on texture, with some textures fooling us into thinking that an object is moving faster than it is, according to a study published Aug. 27, 2019, in the open-access journal PLOS Biology by Sliman Bensmaia of the University of Chicago, and colleagues.

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Crows consciously control their calls

Crows can voluntarily control the release and onset of their calls, suggesting that songbird vocalizations are under cognitive control, according to a study published Aug. 27, 2019, in the open-access journal PLOS Biology by Katharina Brecht of the University of Tübingen, and colleagues.

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Great Barrier Reef expert panel says Peter Ridd misrepresenting science

Exclusive: Panel head Ian Chubb compares ‘roadshow of Dr Ridd’ to tobacco industry strategy defending smoking An expert panel led by the former chief scientist Ian Chubb has warned ministers that controversial scientist Peter Ridd is misrepresenting robust science about the plight of the Great Barrier Reef, and compared his claims to the strategy used by the tobacco industry to raise doubt about

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The Land Battle Behind the Fires in the Amazon

Over the past week, as fires have sent up enough smoke to darken the skies of São Paulo , the world has rallied concern for the fate of the Amazon. At the G7 summit, leaders pledged support and $20 million to help fight the fires, only to have that amount rejected by Brazilian President Jair Bolsonaro, who claims that the Amazon belongs to Brazil and that the country’s “sovereignty” is under thre

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White Claw Is What Happens When Being Cool Becomes Exhausting

Last week, the local police department in Portland, Maine, delivered a reminder to its community via Twitter: There are, in fact, laws when you’re drinking Claws. A few days later, cops in Kenosha, Wisconsin, did the same on Facebook . Authorities in Bath Township, Michigan, then took the warning one step further , eliciting more than 1,000 Facebook comments on a post that reminded people there a

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Ex-Google engineer accused of giving stolen self-driving car secrets to Uber

Prosecutors say Anthony Levandowski stole thousands of secret documents on Google's self-driving car technology before quitting the company — he later went on to …

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Facebook wants to keep you 'in-the-know' about emergencies, active shooters in your area

While Facebook isn't an actual news organization, its flexing its ability to reach users faster than local news channels in some time-sensitive cases.

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The genealogy of important broiler ancestor revealed

A new study examines the historical and genetic origins of the White Plymouth Rock chicken, an important contributor to today's meat chickens (broilers). Researchers have used genomics to study breed formation and the roots of modern broilers.

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Interactions discovered in cells insulating nerve pathways

Schwann cells form a protective sheath around nerve fibers and ensure that nerve impulses are transmitted rapidly. If these cells are missing or damaged, severe neurological diseases may occur as a result. Researchers have succeeded in demonstrating a complex interaction within Schwann cells which plays an important role for correct cell maturation.

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Land-use program fosters white-tailed deer populations in USA

A land-use program piloted in the United States is having a long-term positive impact on populations of white-tailed deer, according to new research.

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How to tell if you've found Mr. or Mrs. Right? For lemurs, it's in their B.O.

Many people turn to the Internet to find a Mr. or Ms. Right. But lemurs don't have to cyberstalk potential love interests to find a good match — they just give them a sniff. A study of lemur scents finds that an individual's distinctive body odor reflects genetic differences in their immune system, and that other lemurs can detect these differences by smell. The ability could help their offspring

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NASA camera captures Amazon fires

The Amazon fires were captured by the AIRS camera on the Aqua satellite. A movie clip released by NASA shows a huge cloud of CO drifting across the continent. Fortunately, carbon monoxide at this altitude has little effect on air quality. Infrared evidence Your browser does not support the video tag. You don't need eyes to see the massive fires raging in the Amazon. An infrared camera fitted on a

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Crows consciously control their calls

Crows can voluntarily control the release and onset of their calls, suggesting that songbird vocalizations are under cognitive control, according to a study published August 27 in the open-access journal PLOS Biology by Katharina Brecht of the University of Tübingen, and colleagues.

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Tattoo needles leave more than just ink

Metal particles find their way into the lymph nodes, study finds.

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Sometimes when we touch, the honesty is absent

Nerve-endings consistently misinterpret the speed of moving textiles. Barry Keily reports.

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Enlarged chamber increases risk of heart failure

New study fuels debate about the value of tests. Paul Biegler reports.

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Crows consciously control their calls

Crows can voluntarily control the release and onset of their calls, suggesting that songbird vocalizations are under cognitive control, according to a study published August 27 in the open-access journal PLOS Biology by Katharina Brecht of the University of Tübingen, and colleagues.

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It’s a tough diet, but it may have a place

Study suggests alternate-day fasting is effective and safe.

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Heading for the jungle? Pack a little graphene

It’s a two-pronged defence against mosquitoes, research shows.

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Keeping an eye on the eye

Map provides insights into the retina’s genetic code

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Prehistoric puma feces reveals oldest parasite DNA ever recorded

The oldest parasite DNA ever recorded has been found in the ancient, desiccated feces of a puma.

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Børn med ADHD har ekstra svært ved at koncentrere sig – men hvorfor?

Cirka to til tre procent af alle skolebørn i Danmark har ADHD, ifølge ADHD-foreningen.

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The Guardian view on the menopause at work: a healthy conversation | Editorial

From new employee entitlements to soap opera storylines, older women’s health needs a bigger profile Connected as it is with ageing, it is not surprising that the menopause has a bad reputation. Even for women who have generally found their periods to be a nuisance, the cessation of the monthly cycle of egg production often comes as a shock. As well as the psychological impact of what used to euph

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Edited genes are not ready to be inherited

DNA changes should benefit patients but not yet their descendants

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Newly discovered giant planet slingshots around its star

Astronomers have discovered a planet three times the mass of Jupiter that travels on a long, egg-shaped path around its star. If this planet were somehow placed into our own solar system, it would swing from within our asteroid belt to out beyond Neptune. Other giant planets with highly elliptical orbits have been found around other stars, but none of those worlds were located at the very outer re

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Scammers are targeting your calendar—here's how to stop them

Google recently published a video explaining what to do if you see spam in your Calendar. (Google/) Your Google calendar is a sacred, semi-private place full of scheduled meetings you’d rather not attend and appointments you’d probably like to skip. So when spam suddenly appears there—advertising something like “Your iPhone XS is ready for PickUp,” followed by a link—it’s jarring and invasive. Th

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Test Riders in Waymo’s Self-Driving Cars Won’t Stop Complaining

Everyone’s A Critic Waymo, the Alphabet-owned self-driving car company , is getting some critical reviews from its passengers in Phoenix and San Francisco. After reviewing records of over 10,500 rides in the company’s self-driving vehicles over the course of July and August, The Information found that a large number of passengers complained about the autonomous vehicles’ performance. While Waymo

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Microsoft is sending out invitations to a mysterious Surface event on October 2

Microsoft has several products in the works right now, including an entirely new Xbox console (dubbed "Project Scarlet" at the moment), an AirPod competitor, and possibly even a dual-screen …

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Scientists discover 'electron equivalents' in colloidal systems

Scientists tethered smaller particles in colloidal crystals to larger ones using DNA, allowing them to determine how the smaller particles filled in the regions surrounding the larger ones.

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Explainer: Role of the Amazon in global climate change

Fires across the Brazilian Amazon have sparked an international outcry for preservation of the world*s largest rainforest. Here's a look at the role the Amazon plays in regulating the world's climate:

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NASA finds Tropical Depression battling wind shear off the Carolina coast

Newly formed Tropical Depression 6 in the Atlantic Ocean may have just formed, but it did so under adverse atmospheric conditions. The depression is battling wind shear and it's apparent on imagery from NASA's Aqua satellite.

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Scientists discover 'electron equivalents' in colloidal systems

Atoms have a positively charged center surrounded by a cloud of negatively charged particles. This type of arrangement, it turns out, can also occur at a more macroscopic level, giving new insights into the nature of how materials form and interact.

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The positives of climate change? Research shows agricultural, economic possibilities

Depending on your side of the aisle, climate change either elicits doomsday anxiety or unabashed skepticism.

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Oldest parasite DNA yet recorded found in prehistoric puma poo

Coprolite reveals felines in southern Andes had roundworm 17,000 years ago, long before humans got there The compact, gnarled and knobbly specimen looks like a root of ginger. In fact, it’s 17,000-year-old puma poo, and it contains the oldest parasite DNA yet recorded. The team of researchers behind the discovery say the finding not only confirms that the felines were prowling around the Andes to

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Prenatal pesticide exposure linked to changes in teen's brain activity

Prenatal exposure to the organophosphate pesticides has been linked to poorer cognition and behavior problems in children. A new study is one of the first to use advanced brain imaging to reveal how exposure can actually change brain activity. Teenagers estimated to have higher levels of prenatal exposure to organophosphates showed altered brain activity compared to their peers while performing ta

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Scientists discover 'electron equivalents' in colloidal systems

Scientists tethered smaller particles in colloidal crystals to larger ones using DNA, allowing them to determine how the smaller particles filled in the regions surrounding the larger ones.

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Changing partners doesn't change relationship dynamics

New romances eventually follow patterns similar to old ones, according to a new study.

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Seeing it both ways: Visual perspective in memory

Think of a memory from your childhood. Are you seeing the memory through your own eyes, or can you see yourself, while viewing that child as if you were an observer?

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Gene linked to autism undergoes changes in men's sperm after pot use

A specific gene associated with autism appears to undergo changes in the sperm of men who use marijuana, according to new research. The gene change occurs through a process called DNA methylation, and it could potentially be passed along to offspring.

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Wild Bill's Deckhand Crushes His Hand | Deadliest Catch

The bone-breaking winter unleashes its fury on the Summer Bay. Stream Full Episodes of Deadliest Catch: https://go.discovery.com/tv-shows/deadliest-catch/ Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Join us on Facebook: https://www.facebook.com/DeadliestCatch https://www.facebook.com/Discovery Follow us on Twitter: https://twitter.com/DeadliestCatch https://twitter.com/Discovery From

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Social media stress can lead to social media addiction

Social network users risk becoming more and more addicted to social media platforms even as they experience stress from their use. Research into the habits of 444 Facebook users revealed they would switch between activities such as chatting to friends, scanning news feeds and posting updates as each began to cause stress. This leads to an increased likelihood of technology addiction, as they use t

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The genealogy of important broiler ancestor revealed

A new study examines the historical and genetic origins of the White Plymouth Rock chicken, an important contributor to today's meat chickens (broilers). Researchers at Uppsala University in Sweden, The Livestock Conservancy and Virginia Tech in the USA have used genomics to study breed formation and the roots of modern broilers.

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'Surrey swarm' earthquakes not caused by nearby oil extraction, says study

The series of 34 small earthquakes between April 2018 and May 2019 occurred within 10 km of two active oil extraction sites at Brockham and Horse Hill in Surrey.

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NASA analyzes Tropical Storm Dorian day and night

Tropical Storm Dorian was approaching the Leeward Islands when NASA-NOAA's Suomi NPP satellite passed overhead from space and snapped a visible image of the storm. When Suomi NPP came by again the satellite provided a night-time image from early morning on Aug. 27.

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The genealogy of important broiler ancestor revealed

A new study examines the historical and genetic origins of the White Plymouth Rock chicken, an important contributor to today's meat chickens (broilers). Researchers at Uppsala University in Sweden, The Livestock Conservancy and Virginia Tech in the USA have used genomics to study breed formation and the roots of modern broilers.

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NASA-NOAA satellite tracks tropical depression Podul across Philippines

Tropical Depression 13W, now named Podul, was crossing the Philippines from east to west as NASA-NOAA's Suomi NPP satellite provided a visible image of the storm.

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Never Trumpers Want a GOP Alternative. Most Republicans Don’t.

In 2012, an unknown candidate named Keith Judd registered a stunning 41 percent of the vote against then-President Barack Obama in the West Virginia Democratic primary. Neither man had even campaigned in the state leading up to the election, although Judd, at least, had a good excuse: He was incarcerated in a Texas prison at the time , serving a 17-year sentence for extortion. This year, Presiden

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Land-use program fosters white-tailed deer populations in USA

A land-use program piloted in the United States is having a long-term positive impact on populations of white-tailed deer, according to new research by University of Alberta biologists.

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How to tell if you've found Mr. or Mrs. Right? For lemurs, it's in their B.O.

Many people turn to the Internet to find a Mr. or Ms. Right. But lemurs don't have to cyberstalk potential love interests to find a good match—they just give them a sniff.

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Corruption among India's factory inspectors makes labour regulation costly

New research shows that 'extortionary' corruption on the part of factory inspectors in India is helping to drive up the cost of the country's labour regulations to business.

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Glacier-fed rivers may consume atmospheric carbon dioxide

Glacier-fed rivers in northern Canada may be consuming significant amounts of carbon dioxide from the atmosphere, according to new research.

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New breathalyzer can detect marijuana

A team has developed a breathalyzer device that can measure the amount of tetrahydrocannabinol (THC), the psychoactive compound in marijuana, in the user's breath. The breathalyzer was developed using carbon nanotubes, tiny tubes of carbon 100,000 times smaller than a human hair. Nanotechnology sensors can detect THC at levels comparable to or better than mass spectrometry, which is considered the

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Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission [Microbiology]

Transmission of Plasmodium falciparum involves a complex process that starts with the ingestion of gametocytes by female Anopheles mosquitoes during a blood meal. Activation of gametocytes in the mosquito midgut triggers “rounding up” followed by egress of both male and female gametes. Egress requires secretion of a perforin-like protein, PfPLP2,…

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Human GNPTAB stuttering mutations engineered into mice cause vocalization deficits and astrocyte pathology in the corpus callosum [Neuroscience]

Stuttering is a common neurodevelopmental disorder that has been associated with mutations in genes involved in intracellular trafficking. However, the cellular mechanisms leading to stuttering remain unknown. Engineering a mutation in N-acetylglucosamine-1-phosphate transferase subunits α and β (GNPTAB) found in humans who stutter into the mouse Gnptab gene resulted in…

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Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha [Pharmacology]

Folates are critical for central nervous system function. Folate transport is mediated by 3 major pathways, reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptor alpha (FRα/Folr1), known to be regulated by ligand-activated nuclear receptors. Cerebral folate delivery primarily occurs at the choroid plexus through FRα and PCFT;…

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Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors [Physiology]

Tactile information is detected by thermoreceptors and mechanoreceptors in the skin and integrated by the central nervous system to produce the perception of somatosensation. Here we investigate the mechanism by which thermal and mechanical stimuli begin to interact and report that it is achieved by the mechanotransduction apparatus in cutaneous…

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Arabidopsis BRUTUS-LIKE E3 ligases negatively regulate iron uptake by targeting transcription factor FIT for recycling [Plant Biology]

Organisms need to balance sufficient uptake of iron (Fe) with possible toxicity. In plant roots, a regulon of uptake genes is transcriptionally activated under Fe deficiency, but it is unknown how this response is inactivated when Fe becomes available. Here we describe the function of 2 partially redundant E3 ubiquitin…

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Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection [Microbiology]

In contrast to the importance of type II interferon-γ (IFN-γ) in control of toxoplasmosis, the role of type I IFN is less clear. We demonstrate here that TgIST, a secreted effector previously implicated in blocking type II IFN-γ signaling, also blocked IFN-β responses by inhibiting STAT1/STAT2-mediated transcription in infected cells….

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Alternative promoters drive human cytomegalovirus reactivation from latency [Microbiology]

Reactivation from latency requires reinitiation of viral gene expression and culminates in the production of infectious progeny. The major immediate early promoter (MIEP) of human cytomegalovirus (HCMV) drives the expression of crucial lytic cycle transactivators but is silenced during latency in hematopoietic progenitor cells (HPCs). Because the MIEP has poor…

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Learning active sensing strategies using a sensory brain-machine interface [Neuroscience]

Diverse organisms, from insects to humans, actively seek out sensory information that best informs goal-directed actions. Efficient active sensing requires congruity between sensor properties and motor strategies, as typically honed through evolution. However, it has been difficult to study whether active sensing strategies are also modified with experience. Here, we…

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Structure and dynamics of G protein-coupled receptor-bound ghrelin reveal the critical role of the octanoyl chain [Pharmacology]

Ghrelin plays a central role in controlling major biological processes. As for other G protein-coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to its receptor remain obscure. Using a combination of solution-state NMR and molecular modeling, we demonstrate that binding to the growth hormone secretagogue receptor…

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Akt phosphorylation of neuronal nitric oxide synthase regulates gastrointestinal motility in mouse ileum [Physiology]

Nitric oxide (NO) is a major inhibitory neurotransmitter that mediates nonadrenergic noncholinergic (NANC) signaling. Neuronal NO synthase (nNOS) is activated by Ca2+/calmodulin to produce NO, which causes smooth muscle relaxation to regulate physiologic tone. nNOS serine1412 (S1412) phosphorylation may reduce the activating Ca2+ requirement and sustain NO production. We developed…

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Regulation of photoprotection gene expression in Chlamydomonas by a putative E3 ubiquitin ligase complex and a homolog of CONSTANS [Plant Biology]

Photosynthetic organisms use nonphotochemical quenching (NPQ) mechanisms to dissipate excess absorbed light energy and protect themselves from photooxidation. In the model green alga Chlamydomonas reinhardtii, the capacity for rapidly reversible NPQ (qE) is induced by high light, blue light, and UV light via increased expression of LHCSR and PSBS genes…

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The catalytic core of DEMETER guides active DNA demethylation in Arabidopsis [Plant Biology]

The Arabidopsis DEMETER (DME) DNA glycosylase demethylates the maternal genome in the central cell prior to fertilization and is essential for seed viability. DME preferentially targets small transposons that flank coding genes, influencing their expression and initiating plant gene imprinting. DME also targets intergenic and heterochromatic regions, but how it…

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Phosphorylation-guarded light-harvesting complex II contributes to broad-spectrum blast resistance in rice [Plant Biology]

Environmental conditions are key factors in the progression of plant disease epidemics. Light affects the outbreak of plant diseases, but the underlying molecular mechanisms are not well understood. Here, we report that the light-harvesting complex II protein, LHCB5, from rice is subject to light-induced phosphorylation during infection by the rice…

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Dynamic regulation of chromatin topology and transcription by inverted repeat-derived small RNAs in sunflower [Plant Biology]

Transposable elements (TEs) are extremely abundant in complex plant genomes. siRNAs of 24 nucleotides in length control transposon activity in a process that involves de novo methylation of targeted loci. Usually, these epigenetic modifications trigger nucleosome condensation and a permanent silencing of the affected loci. Here, we show that a…

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Energy metabolism controls phenotypes by protein efficiency and allocation [Systems Biology]

Cells require energy for growth and maintenance and have evolved to have multiple pathways to produce energy in response to varying conditions. A basic question in this context is how cells organize energy metabolism, which is, however, challenging to elucidate due to its complexity, i.e., the energy-producing pathways overlap with…

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Correction for Piccardo et al., Radio frequency transmitter based on a laser frequency comb [Correction]

APPLIED PHYSICAL SCIENCES Correction for “Radio frequency transmitter based on a laser frequency comb,” by Marco Piccardo, Michele Tamagnone, Benedikt Schwarz, Paul Chevalier, Noah A. Rubin, Yongrui Wang, Christine A. Wang, Michael K. Connors, Daniel McNulty, Alexey Belyanin, and Federico Capasso, which was first published April 24, 2019; 10.1073/pnas.1903534116 (Proc….

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Correction for Wu et al., Wettability effect on nanoconfined water flow [Correction]

ENGINEERING Correction for “Wettability effect on nanoconfined water flow,” by Keliu Wu, Zhangxin Chen, Jing Li, Xiangfang Li, Jinze Xu, and Xiaohu Dong, which was first published March 13, 2017; 10.1073/pnas.1612608114 (Proc. Natl. Acad. Sci. U.S.A. 114, 3358–3363). The authors note that the reference to a previously published version of…

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Correction for Shpigler et al., Deep evolutionary conservation of autism-related genes [Correction]

EVOLUTION Correction for “Deep evolutionary conservation of autism-related genes,” by Hagai Y. Shpigler, Michael C. Saul, Frida Corona, Lindsey Block, Amy Cash Ahmed, Sihai D. Zhao, and Gene E. Robinson, which was first published July 31, 2017; 10.1073/pnas.1708127114 (Proc. Natl. Acad. Sci. U.S.A. 114, 9653–9658). The authors note that on…

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Correction for Yang et al., Leveraging abscisic acid receptors for efficient water use in Arabidopsis [Correction]

PLANT BIOLOGY Correction for “Leveraging abscisic acid receptors for efficient water use in Arabidopsis,” by Zhenyu Yang, Jinghui Liu, Stefanie V. Tischer, Alexander Christmann, Wilhelm Windisch, Hans Schnyder, and Erwin Grill, which was first published May 31, 2016; 10.1073/pnas.1601954113 (Proc. Natl. Acad. Sci. U.S.A. 113, 6791–6796). The authors wish to…

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In This Issue [This Week in PNAS]

How ocean eddies influence blue shark foraging Blue shark. Image courtesy of Tom Burns (photographer). Anticyclonic eddies, masses of water swirling clockwise in oceans’ pelagic zones, make up oceans’ internal weather systems and are generally considered nutrient deserts due to their low productivity. Powerful anticyclonic eddies draw warm water from…

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Do X-ray spectroscopies provide evidence for continuous distribution models of water at ambient conditions? [Physical Sciences]

Ambient water properties have been shown to require heterogeneity (1). Niskanen et al. (2) apply a linear relationship between the intensity of the 4a1 excitation in an electron energy loss spectroscopy gas-phase spectrum and the preedge in water and ice from X-ray Raman scattering to extract the number of hydrogen…

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Reply to Pettersson et al.: Why X-ray spectral features are compatible to continuous distribution models in ambient water [Physical Sciences]

“Ambient water properties have been shown to require heterogeneity” (1) is the imperative followed by Pettersson et al. (2) to relate X-ray spectroscopic findings to a heterogeneous or 2-phase model of ambient water. In ref. 3 we question this hypothesis based on quantitative X-ray spectroscopic evidence. We come to conclude…

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Scenarios where increased population size can enhance cumulative cultural evolution are likely common [Social Sciences]

Fay et al. (1) suggest that larger populations do not enhance cumulative cultural evolution (CCE), as working memory becomes taxed while consciously processing additional social models. This decrease in working memory leads to a reduction in high-fidelity copying. Results from a large study (n = 543) are largely consistent with…

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Reply to Martens: Various factors may enable large populations to enhance cumulative cultural evolution, but more evidence is needed [Social Sciences]

Martens (1) suggests that including model-based bias (e.g., prestige) in our experiment would have enhanced cumulative cultural evolution (CCE) in the larger populations reported in our paper (2). This is a plausible hypothesis, but not one our experiment was designed to test. Given the controversy around the relationship between population…

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Profile of Claire L. Parkinson [Profiles]

When people think of research at the National Aeronautics and Space Administration (NASA), sea ice may not be the first thing that comes to mind. Yet Claire Parkinson, a climate scientist at NASA’s Goddard Space Flight Center in Maryland, has spent 4 decades studying sea ice. Parkinson’s use of satellite…

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Ubiquitin in disguise unveils a cryptic binding site in 1.2-MDa anaphase-promoting complex/cyclosome [Biochemistry]

Ubiquitin serves as a protein modifier and pervasive signaling molecule in eukaryotes, regulating major events throughout the lifetime of a cell, including pathways used for synthesis, repair, and degradation. Aptly named for its ubiquitous presence in human cells, proteomics studies have revealed tens of thousands of sites in ∼5,000 substrates,…

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Unknown actor in adipose tissue metabolism hiding in plain sight [Immunology and Inflammation]

In PNAS Eom et al. (1) report that viperin (virus-inhibitory protein, endoplasmic reticulum-associated, interferon-inducible), which is best known as a nuclear factor κB-induced protein in macrophages involved in the innate immune response, has a heretofore unknown role in the adipocyte. In this paper, the authors investigate the possibility that viperin,…

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The crystal structure of human microsomal triglyceride transfer protein [Biochemistry]

Microsomal triglyceride transfer protein (MTP) plays an essential role in lipid metabolism, especially in the biogenesis of very low-density lipoproteins and chylomicrons via the transfer of neutral lipids and the assembly of apoB-containing lipoproteins. Our understanding of the molecular mechanisms of MTP has been hindered by a lack of structural…

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HuR counteracts miR-330 to promote STAT3 translation during inflammation-induced muscle wasting [Biochemistry]

Debilitating cancer-induced muscle wasting, a syndrome known as cachexia, is lethal. Here we report a posttranscriptional pathway involving the RNA-binding protein HuR as a key player in the onset of this syndrome. Under these conditions, HuR switches its function from a promoter of muscle fiber formation to become an inducer…

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A pathway linking translation stress to checkpoint kinase 2 signaling in Neurospora crassa [Biochemistry]

Checkpoint kinase 2 (CHK-2) is a key component of the DNA damage response (DDR). CHK-2 is activated by the PIP3-kinase-like kinases (PI3KKs) ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related protein (ATR), and in metazoan also by DNA-dependent protein kinase catalytic subunit (DNA-PKcs). These DNA damage-dependent activation pathways are…

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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site [Biochemistry]

Ubiquitin (Ub)-mediated proteolysis is a fundamental mechanism used by eukaryotic cells to maintain homeostasis and protein quality, and to control timing in biological processes. Two essential aspects of Ub regulation are conjugation through E1-E2-E3 enzymatic cascades and recognition by Ub-binding domains. An emerging theme in the Ub field is that…

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Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder [Biochemistry]

Second harmonic generation (SHG) is an emergent biophysical method that sensitively measures real-time conformational change of biomolecules in the presence of biological ligands and small molecules. This study describes the successful implementation of SHG as a primary screening platform to identify fragment ligands to oncogenic Kirsten rat sarcoma (KRas). KRas…

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Motility-limited aggregation of mammary epithelial cells into fractal-like clusters [Biophysics and Computational Biology]

Migratory cells transition between dispersed individuals and multicellular collectives during development, wound healing, and cancer. These transitions are associated with coordinated behaviors as well as arrested motility at high cell densities, but remain poorly understood at lower cell densities. Here, we show that dispersed mammary epithelial cells organize into arrested,…

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Nucleosome positions alone can be used to predict domains in yeast chromosomes [Biophysics and Computational Biology]

We use molecular dynamics simulations based on publicly available micrococcal nuclease sequencing data for nucleosome positions to predict the 3D structure of chromatin in the yeast genome. Our main aim is to shed light on the mechanism underlying the formation of chromosomal interaction domains, chromosome regions of around 0.5 to…

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Spreading of perturbations in myosin group kinetics along actin filaments [Biophysics and Computational Biology]

Global changes in the state of spatially distributed systems can often be traced back to perturbations that arise locally. Whether such local perturbations grow into global changes depends on the system geometry and the spatial spreading of these perturbations. Here, we investigate how different spreading behaviors of local perturbations determine…

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Mutation of external glutamate residue reveals a new intermediate transport state and anion binding site in a CLC Cl-/H+ antiporter [Biophysics and Computational Biology]

The CLC family of proteins are involved in a variety of physiological processes to control cellular chloride concentration. Two distinct classes of CLC proteins, Cl− channels and Cl−/H+ antiporters, have been functionally and structurally investigated over the last several decades. Previous studies have suggested that the conformational heterogeneity of the…

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Single-cell RNA-seq identifies a reversible mesodermal activation in abnormally specified epithelia of p63 EEC syndrome [Cell Biology]

Mutations in transcription factor p63 are associated with developmental disorders that manifest defects in stratified epithelia including the epidermis. The underlying cellular and molecular mechanism is however not yet understood. We established an epidermal commitment model using human induced pluripotent stem cells (iPSCs) and characterized differentiation defects of iPSCs derived…

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Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis [Genetics]

Unfolded protein response (UPR) of the endoplasmic reticulum (UPRER) helps maintain proteostasis in the cell. The ability to mount an effective UPRER to external stress (iUPRER) decreases with age and is linked to the pathophysiology of multiple age-related disorders. Here, we show that a transient pharmacological ER stress, imposed early…

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An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity [Immunology and Inflammation]

Dynamic small ubiquitin-like modifier (SUMO) linkages to diverse cellular protein groups are critical to orchestrate resolution of stresses such as genome damage, hypoxia, or proteotoxicity. Defense against pathogen insult (often reliant upon host recognition of “non-self” nucleic acids) is also modulated by SUMO, but the underlying mechanisms are incompletely understood….

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IL-17 constrains natural killer cell activity by restraining IL-15-driven cell maturation via SOCS3 [Immunology and Inflammation]

Increasing evidence demonstrates that IL-17A promotes tumorigenesis, metastasis, and viral infection. Natural killer (NK) cells are critical for defending against tumors and infections. However, the roles and mechanisms of IL-17A in regulating NK cell activity remain elusive. Herein, our study demonstrated that IL-17A constrained NK cell antitumor and antiviral activity…

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Intrinsic expression of viperin regulates thermogenesis in adipose tissues [Immunology and Inflammation]

Viperin is an interferon (IFN)-inducible multifunctional protein. Recent evidence from high-throughput analyses indicates that most IFN-inducible proteins, including viperin, are intrinsically expressed in specific tissues; however, the respective intrinsic functions are unknown. Here we show that the intrinsic expression of viperin regulates adipose tissue thermogenesis, which is known to counter

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ARF6 and AMAP1 are major targets of KRAS and TP53 mutations to promote invasion, PD-L1 dynamics, and immune evasion of pancreatic cancer [Medical Sciences]

Although KRAS and TP53 mutations are major drivers of pancreatic ductal adenocarcinoma (PDAC), the incurable nature of this cancer still remains largely elusive. ARF6 and its effector AMAP1 are often overexpressed in different cancers and regulate the intracellular dynamics of integrins and E-cadherin, thus promoting tumor invasion and metastasis when…

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Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation [Medical Sciences]

Natural killer (NK) cells inhibit tumor development in mouse models and their presence in tumors correlates with patient survival. However, tumor-associated NK cells become dysfunctional; thus, stimulation of NK cells in cancer is emerging as an attractive immunotherapeutic strategy. In a mouse model of lung adenocarcinoma, NK cells localized to…

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iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition [Medical Sciences]

The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that regulates myriad genes instrumental in diverse cellular outcomes including growth arrest and cell death. Cell context-dependent p53 modulation is critical for this life-or-death balance, yet remains incompletely understood. Here we identify sequence signatures enriched in…

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Intermembrane transport: Glycerophospholipid homeostasis of the Gram-negative cell envelope [Microbiology]

This perspective addresses recent advances in lipid transport across the Gram-negative inner and outer membranes. While we include a summary of previously existing literature regarding this topic, we focus on the maintenance of lipid asymmetry (Mla) pathway. Discovered in 2009 by the Silhavy group [J. C. Malinverni, T. J. Silhavy,…

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Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe [Anthropology]

Archaeological evidence indicates that pig domestication had begun by ∼10,500 y before the present (BP) in the Near East, and mitochondrial DNA (mtDNA) suggests that pigs arrived in Europe alongside farmers ∼8,500 y BP. A few thousand years after the introduction of Near Eastern pigs into Europe, however, their characteristic…

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Ballistic thermal phonons traversing nanocrystalline domains in oriented polyethylene [Applied Physical Sciences]

Thermally conductive polymer crystals are of both fundamental and practical interest for their high thermal conductivity that exceeds that of many metals. In particular, polyethylene fibers and oriented films with uniaxial thermal conductivity exceeding 50 W⋅m−1⋅K−1 have been reported recently, stimulating interest into the underlying microscopic thermal transport processes. While…

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Hydrophobic catalysis and a potential biological role of DNA unstacking induced by environment effects [Biochemistry]

Hydrophobic base stacking is a major contributor to DNA double-helix stability. We report the discovery of specific unstacking effects in certain semihydrophobic environments. Water-miscible ethylene glycol ethers are found to modify structure, dynamics, and reactivity of DNA by mechanisms possibly related to a biologically relevant hydrophobic catalysis. Spectroscopic data and…

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Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics [Biochemistry]

The peptide natural product nisin has been used as a food preservative for 6 decades with minimal development of resistance. Nisin contains the unusual amino acids dehydroalanine and dehydrobutyrine, which are posttranslationally installed by class I lanthipeptide dehydratases (LanBs) on a linear peptide substrate through an unusual glutamyl-tRNA–dependent dehydration of…

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High stretchability, strength, and toughness of living cells enabled by hyperelastic vimentin intermediate filaments [Biophysics and Computational Biology]

In many developmental and pathological processes, including cellular migration during normal development and invasion in cancer metastasis, cells are required to withstand severe deformations. The structural integrity of eukaryotic cells under small deformations has been known to depend on the cytoskeleton including actin filaments (F-actin), microtubules (MT), and intermediate filaments…

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Prebiotic amino acids bind to and stabilize prebiotic fatty acid membranes [Biophysics and Computational Biology]

The membranes of the first protocells on the early Earth were likely self-assembled from fatty acids. A major challenge in understanding how protocells could have arisen and withstood changes in their environment is that fatty acid membranes are unstable in solutions containing high concentrations of salt (such as would have…

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Structural and functional analyses of photosystem II in the marine diatom Phaeodactylum tricornutum [Biophysics and Computational Biology]

A descendant of the red algal lineage, diatoms are unicellular eukaryotic algae characterized by thylakoid membranes that lack the spatial differentiation of stroma and grana stacks found in green algae and higher plants. While the photophysiology of diatoms has been studied extensively, very little is known about the spatial organization…

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Generalized size scaling of metabolic rates based on single-cell measurements with freshwater phytoplankton [Biophysics and Computational Biology]

Kleiber’s law describes the scaling of metabolic rate with body size across several orders of magnitude in size and across taxa and is widely regarded as a fundamental law in biology. The physiological origins of Kleiber’s law are still debated and generalizations of the law accounting for deviations from the…

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Controlling the material properties and rRNA processing function of the nucleolus using light [Biophysics and Computational Biology]

The nucleolus is a prominent nuclear condensate that plays a central role in ribosome biogenesis by facilitating the transcription and processing of nascent ribosomal RNA (rRNA). A number of studies have highlighted the active viscoelastic nature of the nucleolus, whose material properties and phase behavior are a consequence of underlying…

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Autophosphorylation is sufficient to release Mps1 kinase from native kinetochores [Biophysics and Computational Biology]

Accurate mitosis depends on a surveillance system called the spindle assembly checkpoint. This checkpoint acts at kinetochores, which attach chromosomes to the dynamic tips of spindle microtubules. When a kinetochore is unattached or improperly attached, the protein kinase Mps1 phosphorylates kinetochore components, catalyzing the generation of a diffusible “wait” signal…

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Nanoscale oxygen defect gradients in UO2+x surfaces [Chemistry]

Oxygen defects govern the behavior of a range of materials spanning catalysis, quantum computing, and nuclear energy. Understanding and controlling these defects is particularly important for the safe use, storage, and disposal of actinide oxides in the nuclear fuel cycle, since their oxidation state influences fuel lifetimes, stability, and the…

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Rainfall variations in central Indo-Pacific over the past 2,700 y [Earth, Atmospheric, and Planetary Sciences]

Tropical rainfall variability is closely linked to meridional shifts of the Intertropical Convergence Zone (ITCZ) and zonal movements of the Walker circulation. The characteristics and mechanisms of tropical rainfall variations on centennial to decadal scales are, however, still unclear. Here, we reconstruct a replicated stalagmite-based 2,700-y-long, continuous record of rainfall…

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A productivity collapse to end Earth’s Great Oxidation [Earth, Atmospheric, and Planetary Sciences]

It has been hypothesized that the overall size of—or efficiency of carbon export from—the biosphere decreased at the end of the Great Oxidation Event (GOE) (ca. 2,400 to 2,050 Ma). However, the timing, tempo, and trigger for this decrease remain poorly constrained. Here we test this hypothesis by studying the…

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Mesoscale eddies release pelagic sharks from thermal constraints to foraging in the ocean twilight zone [Ecology]

Mesoscale eddies are critical components of the ocean’s “internal weather” system. Mixing and stirring by eddies exerts significant control on biogeochemical fluxes in the open ocean, and eddies may trap distinctive plankton communities that remain coherent for months and can be transported hundreds to thousands of kilometers. Debate regarding how…

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Biomass losses resulting from insect and disease invasions in US forests [Ecology]

Worldwide, forests are increasingly affected by nonnative insects and diseases, some of which cause substantial tree mortality. Forests in the United States have been invaded by a particularly large number (>450) of tree-feeding pest species. While information exists about the ecological impacts of certain pests, region-wide assessments of the composite…

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Mapping the effects of drought on child stunting [Environmental Sciences]

As climate change continues, it is expected to have increasingly adverse impacts on child nutrition outcomes, and these impacts will be moderated by a variety of governmental, economic, infrastructural, and environmental factors. To date, attempts to map the vulnerability of food systems to climate change and drought have focused on…

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Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors [Genetics]

Gross Chromosomal Rearrangements (GCRs) play an important role in human diseases, including cancer. Although most of the nonessential Genome Instability Suppressing (GIS) genes in Saccharomyces cerevisiae are known, the essential genes in which mutations can cause increased GCR rates are not well understood. Here 2 S. cerevisiae GCR assays were…

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A dynamical motif comprising the interactions between antigens and CD8 T cells may underlie the outcomes of viral infections [Immunology and Inflammation]

Some viral infections culminate in very different outcomes in different individuals. They can be rapidly cleared in some, cause persistent infection in others, and cause mortality from immunopathology in yet others. The conventional view is that the different outcomes arise as a consequence of the complex interactions between a large…

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Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity [Medical Sciences]

Gastrointestinal (GI) syndrome is a serious side effect and dose-limiting toxicity observed in patients undergoing lower-abdominal radiotherapy. Previous mouse studies show that p53 gene dosage determines susceptibility to GI syndrome development. However, the translational relevance of p53 activity has not been addressed. Here, we used a knock-in mouse in which…

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MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers [Medical Sciences]

Defects in DNA repair give rise to genomic instability, leading to neoplasia. Cancer cells defective in one DNA repair pathway can become reliant on remaining repair pathways for survival and proliferation. This attribute of cancer cells can be exploited therapeutically, by inhibiting the remaining repair pathway, a process termed synthetic…

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Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage [Medical Sciences]

Trauma hemorrhage is a leading cause of death and disability worldwide. Platelets are fundamental to primary hemostasis, but become profoundly dysfunctional in critically injured patients by an unknown mechanism, contributing to an acute coagulopathy which exacerbates bleeding and increases mortality. The objective of this study was to elucidate the mechanism…

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Graphene-like monolayer monoxides and monochlorides [Physics]

Two-dimensional monolayer materials, with thicknesses of up to several atoms, can be obtained from almost every layer-structured material. It is believed that the catalogs of known 2D materials are almost complete, with fewer new graphene-like materials being discovered. Here, we report 2D graphene-like monolayers from monoxides such as BeO, MgO,…

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Race influences professional investors’ financial ȷudgments [Psychological and Cognitive Sciences]

Of the $69.1 trillion global financial assets under management across mutual funds, hedge funds, real estate, and private equity, fewer than 1.3% are managed by women and people of color. Why is this powerful, elite industry so racially homogenous? We conducted an online experiment with actual asset allocators to determine…

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News Feature: The quest for the sustainable city [Sustainability Science]

Cities have become epicenters for confronting climate change, harnessing renewable energy, and mitigating pollution. The city plans striving for sustainability are many. Easy solutions are few. On April 17, Los Angeles (LA) Mayor Eric Garcetti used his annual State of the City address (1) to announce a major update of…

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Impacts of climate change on future air quality and human health in China [Sustainability Science]

In recent years, air pollution has caused more than 1 million deaths per year in China, making it a major focus of public health efforts. However, future climate change may exacerbate such human health impacts by increasing the frequency and duration of weather conditions that enhance air pollution exposure. Here,…

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Land-use program fosters white-tailed deer populations in USA

A land-use program piloted in the United States is having a long-term positive impact on populations of white-tailed deer, according to new research by University of Alberta biologists.

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How to tell if you've found Mr. or Mrs. Right? For lemurs, it's in their B.O.

Many people turn to the Internet to find a Mr. or Ms. Right. But lemurs don't have to cyberstalk potential love interests to find a good match—they just give them a sniff.

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How it pays off for kids when parents get involved at school

Kids are less likely to have concentration problems and behavioral issues if their parents make a greater effort to engage with their schooling earlier in the year, according to new research. Parent involvement and support can be beneficial for students of all ages, but the new research shows that family-school involvement has specific perks for young students. After surveying more than 3,170 stu

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Computational approach speeds up advanced microscopy imaging

Researchers have developed a way to enhance the imaging speed of two-photon microscopy up to five times without compromising resolution. This record-fast imaging speed will allow scientists to observe biological phenomena that were previously too fleeting to image with current state-of-the-art advanced microscopy.

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Family-school engagement has specific perks for young students

With school in full swing, many parents might be considering how to get more involved with their child's schooling. Parent involvement and support can be beneficial for students of all ages, but new research shows that family-school involvement has specific perks for young students.

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NASA-NOAA satellite tracks tropical depression Podul across Philippines

Tropical Depression 13W, now named Podul, was crossing the Philippines from east to west as NASA-NOAA's Suomi NPP satellite provided a visible image of the storm.

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Better seizure control with ketogenic diet in infants with genetic epilepsy

Research shows that starting infants as young as 3 weeks old on the ketogenic diet is effective in treating epilepsy.

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NASA analyzes Tropical Storm Dorian day and night

Tropical Storm Dorian was approaching the Leeward Islands when NASA-NOAA's Suomi NPP satellite passed overhead from space and snapped a visible image of the storm. When Suomi NPP came by again the satellite provided a night-time image from early morning on Aug. 27.

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Prenatal pesticide exposure linked to changes in teen's brain activity

Prenatal exposure to the organophosphate pesticides has been linked to poorer cognition and behavior problems in children. A new study led by University of California, Berkeley, researchers is one of the first to use advanced brain imaging to reveal how exposure can actually change brain activity. Teenagers estimated to have higher levels of prenatal exposure to organophosphates showed altered bra

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Scientists discover 'electron equivalents' in colloidal systems

In new research outlined in a recent issue of Science, scientists tethered smaller particles in colloidal crystals to larger ones using DNA, allowing them to determine how the smaller particles filled in the regions surrounding the larger ones.

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Not in Gotham anymore

In her comic-book paper, neuroscientist and artist Ann Fink argues that healing trauma entails obligations to society. She examines the true tale of a psychiatrist and his traumatized patient: a police inspector and domestic abuser who tortures on behalf of a colonial power

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NASA finds Tropical Depression battling wind shear off the Carolina coast

Newly formed Tropical Depression 6 in the Atlantic Ocean may have just formed, but it did so under adverse atmospheric conditions. The depression is battling wind shear and it's apparent on imagery from NASA's Aqua satellite.

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5 reasons why NASA’s 2024 moon landing looks unlikely

The odds that NASA can accomplish its huge task in five years are looking longer and longer with each passing week.

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Streaks in aurora found to map features in earth's radiation environment

A special kind of streaked aurora has been found to track disturbances in near-Earth space from the ground. Known as structured diffuse aurora, it was recently discovered, with the help of NASA spacecraft and instruments, that these faint lights in the night sky can map the edges of the Van Allen radiation belts—hazardous concentric bands of charged particles encircling Earth.

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Mediating the trade-off—how plants decide between growth or defense

Grow or defend yourself—a decision plants need to make on a daily basis, due to their inability to do both simultaneously. For a long time, it was thought that the reason for the growth-defence trade-off might be a question of energy resources. When a plant is defending itself against pathogens, energy could simply be limited for the plant to be growing at the same time, and vice versa. A recent p

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Astronomers find a golden glow from a distant stellar collision

On August 17, 2017, scientists made history with the first direct observation of a merger between two neutron stars. It was the first cosmic event detected in both gravitational waves and the entire spectrum of light, from gamma rays to radio emissions.

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New information on regulation of sense of smell with the help of nematodes

PIM kinases are enzymes that are evolutionarily well conserved in both humans and nematodes. Led by Dr. Päivi Koskinen, a research group from the Department of Biology of the University of Turku in Finland has previously proven that PIM kinases promote the motility and survival of cancer cells, but now the group has shown that these enzymes also regulate the sense of smell.

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Researchers create breathalyzer that can detect marijuana

As recreational marijuana legalization becomes more widespread throughout the U.S., so has concern about what that means for enforcing DUI laws. Unlike a breathalyzer used to detect alcohol, police do not have a device that can be used in the field to determine if a driver is under the influence of marijuana. New research from the University of Pittsburgh is poised to change that.

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Biologists discover and name new fireworm species in Hong Kong waters

A group of biologists from Hong Kong Baptist University (HKBU) have discovered a new fireworm species in Hong Kong waters and named it Chloeia bimaculata. It is the fourth named species to be added to the fireworm genus Chloeia during the last century. The team also identified Chloeia parva as the fireworm species that caused the outbreak in Hong Kong last year. The discovery shows how little peop

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Mediating the trade-off—how plants decide between growth or defense

Grow or defend yourself—a decision plants need to make on a daily basis, due to their inability to do both simultaneously. For a long time, it was thought that the reason for the growth-defence trade-off might be a question of energy resources. When a plant is defending itself against pathogens, energy could simply be limited for the plant to be growing at the same time, and vice versa. A recent p

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