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nyheder2019marts09

Study confirms horseshoe crabs are really relatives of spiders, scorpions

Blue-blooded and armored with 10 spindly legs, horseshoe crabs have perhaps always seemed a bit out of place.

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Facebook tager kampen op mod anti-vaccinebudskaber

Det sociale medie vil begrænse spredningen og fjerne sider med fejlinformation.

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Københavnske hestedrosker skal have taxameter

Med det nye mekaniske apparat skulle det være slut med al strid med kusken om betalingen. Ingeniøren forklarede i 1895 om dets konstruktion og funktion.

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6 signs you’re in an emotionally strong relationship

One of the most important yet underappreciated parts of a happy, fulfilling relationship is emotional strength — but what does that really mean? Research shows that emotional strength primarily comes down to maintaining a healthy perspective , a trait that's ever more important within the context of romantic relationships, where opportunities for miscommunication and unhealthy habits can be plent

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Looking for Nemo

Kids movies shape the way we look at the world long after we leave the theater — Read more on ScientificAmerican.com

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A New Drug Might, Possibly, Have Cured the Flu

Flu Season Influenza kills as many as 650,000 people per year and sickens many more — and even if you get your annual vaccine, you can still catch a flu strain it doesn’t protect against. That’s why doctors are excited about a new experimental treatment that could provide broad protection against many strains of the flu, according to NPR , even at levels of infection that are currently deadly. Th

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New NASA Measurements: Milky Way Galaxy Is “On the Beefier Side”

Dad Bod NASA performed a new measurement of the mass of the Milky Way galaxy using the Hubble and Gaia space telescopes. Not only do the new measurements show that our home galaxy is bigger than many of its peers, but also that the overwhelming majority of that weight is invisible dark matter — opening up tantalizing mysteries about what comprises the portions of the Milky Way we can’t see. “The

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Ny gådefuld spækhuggerart fanget på video

Forskere har ledt efter underart af spækhuggeren i årtier. Nu er arten fanget på video, og den lever måske udbredt ved Antarktis.

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HQ jumping to Daylight Savings

Happy Saturday! This is your twice-yearly reminder that HQ is about to switch timezones, and thus some events may happen slightly differently for players in some countries than they did over the winter. Tomorrow, 3/10 , we will ignore 2:00 AM Eastern Standard Time and zip right to 3:00 AM Eastern Daylight Time . Certain competition event notifications automatically display times according to your

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Bizarre Malware Is Disabling Safety Systems at Industrial Plants

Deadly Malware The world has grown accustomed to malware that steals your credit card information or demands bitcoin to access your files. But a new hacker tool is targeting the safety systems at industrial plants around the world, according to a fascinating investigation in the MIT Technology Review — the same safety systems, ominously, that protect nuclear power stations and water treatment fac

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Japanese PS4 owners can now remap "X" and "O" button functionality

Remote Play on iOS is the flagship feature of Sony’s latest firmware update for the PlayStation 4. Buried within the release notes, however, is a minor change that could be a godsend for non-Japanese …

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Automation For The People? Ohio Valley At High Risk For Job Losses

submitted by /u/gone_his_own_way [link] [comments]

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2019 SkS Weekly Climate Change & Global Warming News Roundup #10

A chronological listing of news articles posted on the Skeptical Science Facebook Page during the past week, i.e., Sun, Mar 3 through Sat, Mar 9, 2019 Editor's Pick Adults won’t take climate change seriously. So we, the youth, are forced to strike. Editor’s note: The authors are the lead organizers of US Youth Climate Strike , part of a global student movement inspired by 16-year-old climate acti

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How Facebook stands to profit from its 'privacy' push

At first glance, Mark Zuckerberg's new "privacy-focused vision " for Facebook looks like a transformative mission statement from a CEO under pressure to reverse years of battering over its surveillance practices and privacy failures.

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What Facebook's 'privacy vision' really means

Mark Zuckerberg's abrupt Wednesday declaration of a new "privacy vision " for social networking was for many people a sort of Rorschach test.

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Wanted: More pastures for West's overpopulated wild horses

If you ever wished to gaze at a stomping, snorting, neighing panorama of Western heritage from your living-room window, now could be your chance.

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Wanted: More pastures for West's overpopulated wild horses

If you ever wished to gaze at a stomping, snorting, neighing panorama of Western heritage from your living-room window, now could be your chance.

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UK lords call for central 'Digital Authority' to help regulate internet

The UK govenment's demand for stricter regulation of internet companies is only growing louder. A report from a House of Lords committee has called for the creation of a central …

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Tesla Investors Sue Elon Musk For Twitter “Misstatements”

Mr. Musk A group of Tesla investors is suing CEO Elon Musk for what they say has been erratic behavior on Twitter that they say could harm the electric car company and its shareholders. “Mr. Musk has continually disregarded all efforts to rein in his material misstatements on social media,” said Michael Barry, the director of the law firm handling the suit, in a statement obtained by CNET . “He h

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Gender equality in STEM is possible. These countries prove it

There should be no shortage of inspirational role models for young girls dreaming of a career in science. Women have been responsible for some of the most important scientific breakthroughs that shaped the modern world, from Marie Curie's discoveries about radiation, to Grace Hopper's groundbreaking work on computer programming, and Barbara McClintock's pioneering approach to genetics. But too of

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Jordan Peele’s Us turns a political statement into unnerving horror

Welcome to Cheat Sheet, our breakdown-style reviews of festival films, VR previews, and other special-event releases. This review comes from the 2019 SXSW Interacti ve Festival. When …

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Doctor Tells Man He’s Going to Die via Telepresence Robot

Terminal Diagnosis A California family is outraged that a doctor told their elderly relative that his lungs were failing that that he was going to die imminently — via a telepresence robot. “You might not make it home,” the doctor at Kaiser Permanente Medical Center told the patient, according to local television channel KTVU , which broke the story. The patient, Ernest Quintana, died two days af

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Residents Are Furious About Google’s Drone Delivery Service

Project Wing Google parent company Alphabet is gearing up to launch what the Australian Broadcasting Corporation reports will be the world’s first commercial drone delivery service, which will fall under its Project Wing arm. But Alphabet may be in for a fight before the delivery program takes flight in Australia by this coming June, according to the ABC — because local residents are furious abou

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Elon Musk’s high-speed tunnel project is the big loser in Chicago’s race for mayor

If elected mayor of Chicago next month, former federal prosecutor Lori Lightfoot may pull the plug on Elon Musk’s proposal to build a high-tech rapid transit system in America’s …

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15-minute laser is best treatment for glaucoma patients, says study

Top surgeon hails fast procedure that saves a lifetime using eye drops Lasers should become the principal method in the UK for treating patients with the debilitating eye condition glaucoma. That is the stark conclusion of a three-year study published on Sunday. The report, which appears in the Lancet , says the laser technique – known as selective laser trabeculoplasty or SLT – should replace the

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Vært på Digitalt: Oprydningsguru bragte orden i min computer og mit liv

Radiovært fik kontrollen over sin hverdag tilbage med hjælp fra en digital Marie Kondo.

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Bill Gates Backed Startup Is Using CRISPR to Grow Lab Meat

Lookin CRISP You already knew about lab-grown meats, which are grown from animal cells instead of in a whole animal. And you probably know about CRISPR, the technology that lets scientists edit DNA with relative ease. Now, Business Insider reports , at least two startups are trying to combine lab grown meats and CRISPR to invent the next generation of lab-grown meat — and it could lead to futuris

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Geneva Motor Show Insanity: Knobs Made of Meteorite and More

The annual gathering is where high-end automakers show their stuff, and this year’s show included a Rolls-Royce offering that’s, well, (from) out of this world.

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Okay, Maybe Proofs Aren't Dying After All

Two experts argue that proofs are doing fine, contrary to a controversial 1993 prediction of their impending demise — Read more on ScientificAmerican.com

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Citrix Internal Network Ravaged By Foreign Hackers, 6TB Of Data Stolen

Citrix Systems said it is cooperating with the Federal Bureau of Investigation (FBI) to investigate a major data breach by international cyber criminals into the company's internal network. …

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NASA’s Stunning Image: Supersonic Shockwaves Smashing Together

Supersonic Flight NASA engineers have captured the first images of the interaction between shockwaves from a pair of flying supersonic aircraft — and they are stunning. “We’re seeing a level of physical detail here that I don’t think anybody has ever seen before,” senior research engineer Dan Banks said in a NASA press release . “Just looking at the data for the first time, I think things worked

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Study confirms horseshoe crabs are really relatives of spiders, scorpions

Blue-blooded and armored with 10 spindly legs, horseshoe crabs have perhaps always seemed a bit out of place.

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A Shocking Partner Reveal | Naked and Afraid

The survivalists are in for an early surprise when they learn they share the same sex as their partner. Stream Full Episodes of Naked and Afraid: https://www.discovery.com/tv-shows/naked-and-afraid/ Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Join us on Facebook: https://www.facebook.com/NakedandAfraid https://www.facebook.com/Discovery Follow us on Twitter: https://twitter.com/Naked

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Space Photos of the Week: The Moon Needs Sunscreen

Plus: Merging galaxies, a stymied InSight, and hydrated minerals.

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US Tracks Journalists, Chelsea Manning Goes to Jail, and More Security News This Week

A surprisingly common password, an NSA spy program winds down, and more security news this week.

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This Week’s Awesome Stories From Around the Web (Through March 9)

MEDICINE HIV Is Reported Cured in a Second Patient, a Milestone in the Global AIDs Epidemic Apoorva Mandavilli | The New York Times “Scientists have long tried to duplicate the procedure that led to the first long-term remission 12 years ago. With the so-called London patient, they seem to have succeeded.” GENE EDITING The Epic Legal Battle Over CRISPR’s Future Could Finally Be Over Nessa Carey |

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Houseplants Don’t Actually Clean the Air

When vine-curious Brooklynites walk into Tula Plants and Design —a small houseplant shop in Greenpoint with a vibrant Instagram presence and a profusion of leaves on every available horizontal surface—the employees know what questions to expect. There are two, according to Ariel Ries, an employee at the store. The first is, “Will this plant kill my pet?” The second is, “What kind of plants are be

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Weekend reads: Journal editor fired for homophobic comments; “three-parent baby” paper mega-correction; the Bette Midler journal club

Before we present this week’s Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured plagiarism by a priest; retraction of a creationist paper “published … Continue reading Weekend reads: Journal editor fired

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Precision drugs could unmask cancers to immune system and boost effects of immunotherapy

Precision cancer drugs called PARP inhibitors have a previously unknown ability to boost the immune system, and could help many more patients benefit from immunotherapy, a new study reveals.

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Horseshoe crabs are really relatives of spiders, scorpions

By analyzing troves of genetic data and considering a vast number of possible ways to examine it, scientists now have a high degree of confidence that horseshoe crabs do indeed belong within the arachnids.

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THOR wrangles complex microbiomes into a model for improving them

Researchers have developed a community they named THOR, three species of bacteria isolated from soybean roots and grown together. The complex community of microbes developed new behaviors together that couldn't be predicted from the individual members alone — they grew tougher structures known as biofilms, changed how they moved across their environment, and controlled the release of a novel anti

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New method of scoring protein interactions mines large data sets from a fresh angle

Researchers have created a novel way to define individual protein associations in a quick, efficient, and informative way. These findings show how the topological scoring (TopS) algorithm, can — by combining data sets — identify proteins that come together.

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Alzheimer's: How does the brain change over the course of the disease?

What changes in the brain are caused by Alzheimer's disease? How do these changes differ from those observed in the normal ageing process? Researchers explored these questions by analyzing over 4,000 MRI scans of healthy and diseased brains using the 'volBrain' platform. Their models reveal an early atrophy of the amygdala and hippocampus at age 40 in patients with Alzheimer's disease.

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VIDEO Sådan får du skovlen under rodet på din computer

Digitalt kaos kan være en stressfaktor i hverdagen. Kan svaret være en app?

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Get Off My Lawn

Kati Lacker F or a long time I thought the problem was all in my head. When I was growing up, I knew that a certain kind of noise was one I needed to avoid. Food blenders in the kitchen, hair dryers in the bathroom, a vacuum cleaner whooshing around—all produced an intense whining sound that, given the specific wiring connections between my ears and my brain, kept me from thinking about anything

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A Fantasy Novel About Building a Big, Dumb Wall

Bestselling author David Baldacci's latest is about a town that builds a barrier to exclude "Outliers."

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The ABS of molecular engines

Peroxisomes are cell organelles that carry out a number of functions, including the degradation of cytotoxins. For this purpose, they require enzymes that have to be transported into peroxisomes via complicated machinery. Scientists have now detected an as-yet unknown transport step, thus gaining a better understanding of life-threatening diseases.

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Do Any Animals Know Their Grandparents?

Do any animals know their grandparents the way people do?

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Antarctica's Bizarre Green Icebergs Are More Than a Quirk of the Southern Ocean

Scientists think they know why some icebergs are emerald.

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What happens to freedom when time is money – with Martin Hägglund

Why hasn't technology given us more freedom? Why is faith in eternal life incompatible with real human progress? Why don't Universal Basic Income and other forms of redistribution solve the underlying problem? None What gets a wolf or a pigeon up in the morning? No offense to wolves or to pigeons, but it's probably not the desire to make the world a better place. As far as we know, humans are uni

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Satellite Photos Show Activity At North Korean Missile Sites

New photographs from commercial satellites are showing activity at a variety of sites related to North Korea's space and missile programs. It could be a sign the North is preparing a launch.

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Researchers Study Blast Injuries In Veterans

Researchers at the Boston VA are finding that exposure to blasts even without concussion can cause structural damage to the brain.

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After a close shave with murder, life in the Arctic helped me overcome debilitating fear

Isolation in Greenland helped stop constant worrying about my daughter’s safety In recent years I’ve often felt on top of the world, but I also know what it’s like to teeter on the edge of the precipice, unsure whether I could save myself. Six years ago, I was an author with two conspiracy thrillers under my belt; both were bestsellers in Denmark and my path as a writer seemed set. But a few shor

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The Curious Power of Giving Book Characters the Same Name

Did you register, dear viewer, that Downton Abbey had two characters named Thomas B: the malignant footman turned loyal butler Thomas Barrow, and the socialist chauffeur turned son-in-law Tom Branson? And if it did, did it bother you? Chances are the answer is no—unless you happen to be Benjamin Dreyer. Dreyer is an expert grammarian and influential arbiter of good writing, whether in the novels

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Best Snow Gear Deals: REI End-of-Season Sale and More

No matter what's happening on Game of Thrones, summer will be here soon. We have the deals to prove it.

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New Film Shows How Bellingcat Cracks the Web's Toughest Cases

*Truth in a Post Truth World* takes a closer look at a team of remarkably resourceful investigative journalists.

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The Best of the Physics arXiv (week ending March 9, 2019)

This week’s most thought-provoking papers from the Physics arXiv.

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Violence Propels Ebola Outbreak Toward 1,000 Cases

Surging conflict in the Democratic Republic of the Congo is hampering efforts to stamp out the virus — Read more on ScientificAmerican.com

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Philadelphia says no to totally cashless future

With an increasing number of US businesses no longer accepting cash, Philadelphia—the City of Brotherly Love—is taking a stand to protect the so-called "unbanked" and will force merchants to …

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Philadelphia says no to totally cashless future

With an increasing number of US businesses no longer accepting cash, Philadelphia—the City of Brotherly Love—is taking a stand to protect the so-called "unbanked" and will force merchants to accept greenbacks.

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US regulators clear path for genetically modified salmon

U.S. regulators on Friday gave the green light to salmon genetically modified to grow about twice as fast as normal, but the company behind it may face legal challenges before the fish can be sold domestically.

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Explorers to send 1st live video broadcast from ocean depths

Explorers are set to deliver the first live video broadcast from deep below an ocean's surface.

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US regulators clear path for genetically modified salmon

U.S. regulators on Friday gave the green light to salmon genetically modified to grow about twice as fast as normal, but the company behind it may face legal challenges before the fish can be sold domestically.

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Study confirms horseshoe crabs are really relatives of spiders, scorpions

Blue-blooded and armored with 10 spindly legs, horseshoe crabs have perhaps always seemed a bit out of place.

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The Last Place Big Tech Wants to Be Is on the Defense

Elizabeth Warren is coming for tech companies. And that means more time and money spent fighting regulation instead of funding innovation.

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Where Have All the Men Without College Degrees Gone?

In the late 1960s, almost all prime-working-age men, typically defined as 25 to 54, worked—nearly 95 percent . That figure had dipped to 85 percent by 2015—a decline most acutely felt among men without college degrees. The trend of men dropping out of the labor force, particularly non-college-educated men, has been building for more than six decades. It has been a slow withdrawal, but a steady on

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Do you guys believe we will make deep dive VR?

I was wondering abut your guys' opinion on deep dive VR, like if it is possible, how far along are we, or any companies invested in it submitted by /u/HeadLetterhead [link] [comments]

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Global Solar Installations Reached 104 Gigawatts In 2018

submitted by /u/bebesiege [link] [comments]

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Ugens debat: Kæmper alle elbiler sammen mod den fælles fjende?

Det Volvo-ejede bilmærke Polestar har præsenteret sin første rene elbil, Polestar 2. Med en rækkevidde på 500 km skal den fra næste år tage kampen op mod især Tesla Model 3. Mange læsere på ing.dk mente, at ‘kampen’ ikke står mellem elbilerne internt, men mellem el og forbrænding. Men at Tesla s…

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6 Reasons Paul Manafort Got Off So Lightly

Paul Manafort, the former campaign manager for President Donald Trump, entered Virginia federal court on Thursday facing a recommended sentence of 19 to 24 years, and left with a sentence of less than four years. Many people are outraged by what they see as an unreasonably lenient penalty for an unrepentant crook, and have accused United States District Judge T. S. Ellis of bias. Others have decr

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Bill Burns: ‘Chaos Serves Putin’s Interest’

William J. Burns, now the head of the Carnegie Endowment for International Peace, in Washington, D.C. is one of America’s most experienced and esteemed diplomats. During his three-decade career in the Foreign Service, he was the United States ambassador to Russia under George W. Bush and a deputy secretary of state under Barack Obama—only the second serving career diplomat ever to hold that posit

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Trilobites: Sometimes Wiping Out Badgers Helped. Sometimes It Didn’t. Why?

Culling wildlife is one way to curb the spread of disease among domestic animals. A new study shows why its effects are often limited.

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The U-curve of happiness: Why old age is a time of psychological bliss

The U-curve of happiness shows that we humans are most content at the beginnings and ends of our lives. The famous midlife crisis is the trough of our happiness because it's a time when we have responsibility for people older and younger than us, and we grow aware that we may not fulfill the dreams of our youth. Children and people in their 80s are uniquely able to live in the moment and be happy

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Life-changing learning from Big Think: Be first, be early, be better.

Become a powerhouse thinker and doer. Sign up for Big Think Edge. Experts like Malcolm Gladwell, John Cleese, Sallie Krawcheck, Daniel Kahneman, Gretchen Rubin, Bryan Cranston + more, teach high-value skills that helped them succeed. Sign up now to receive a 20% discount limited to 1,000 early subscribers. None None None None None None Become a better you – personally and professionally Want to b

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Nobel-winner Paul Nurse on Brexit: ‘The UK is turning in on itself’

Scientists fear the UK has lost its way due to Brexit and research could suffer as a result, one of the country’s most respected scientists tells New Scientist

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Metal instead of paper?

Would it be possible to use very thin(not scraching) threads or shavings of different metals instead of papper tissues? For various applications like toiletpaper, or cosmetic pads, because it could be recycled much easier and faster. What do you think? submitted by /u/Alexander556 [link] [comments]

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I used to pretend my epilepsy didn’t exist. Like a no-deal Brexit, it’s a dangerous game | Hadley Freeman

I try to avoid writing about Brexit. But one question has become too pressing to ignore Like everyone else at this point, I have many questions about Brexit, starting with “why” and going from there. For example: are concerns about how Britain is going to cope merely “project fear”, as some Brexity folk still have it? Is it going to be like the blitz, as other Brexity people have promised enthusi

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Can AI become conscious? Bach, Escher and Gödel's 'strange loops' may have the answer

In 1979, a cult book by Douglas Hofstadter explored consciousness via a mathematical idea found in art and music. Now, in the AI revolution, that concept could solve a vital question This year is the 40th anniversary of the publication of one of the cult books of my generation: Gödel Escher Bach by Douglas Hofstadter . This Pulitzer prize-winning tome was essential reading in the 1980s for emergi

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Arsenic-munching caterpillars may ingest poison to prevent being eaten

Some caterpillars happily dine on arsenic-loaded leaves. Accumulating the poison in their bodies may be a tactic to ward of predators

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Her er fem våben, der kan restaurere koralrevene

PLUS. For at bevare korallerne som vigtige værn for fisk og mennesker, arbejder forskere på nye metoder til at holde dem i live.

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Genredigering og bakterieboost: Blege koralrev får farverne tilbage

PLUS. Forædling, genredigering og kunstig skygge kan blive nødvendige våben, hvis de farvestrålende koralrev skal klare klimaforandringerne.

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A library in Oslo Norway that won't be opened until 2114

submitted by /u/SchreiberBike [link] [comments]

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China’s new “Artificial SUN” will be completed this year

submitted by /u/boundtoreddit [link] [comments]

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‘Circular economy’ could save GCC cities $138bn over a decade

submitted by /u/thinkB4WeSpeak [link] [comments]

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World Science Festival Video March 8, 2019

submitted by /u/Nick-Conner [link] [comments]

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The Anonymous Decentralized Assassination Market

submitted by /u/Smith_421 [link] [comments]

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Tre forskningsprojekt för en grönare stålindustri

Stålindustrin är en av de största utsläpparna av koldioxid i Sverige. Helén Axelsson, energi- och miljödirektör på stålindustrins branschorganisation Jernkontoret, berättar om tre forskningsprojekt som jobbar mot en grönare stålverksamhet.

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Mot en klimatvänligare stålindustri

Stålindustrin i Sverige släpper ut störst mängd koldioxid av landets alla industrier. På Luleå tekniska universitet forskas det på hur man med biologiska metoder kan fånga in utsläppen och göra industrin miljövänligare.

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Global Health: Bit by Bit, Scientists Gain Ground on AIDS

The “London patient,” apparently cured of H.I.V. infection, has gotten all the attention. But other recently revealed advances are more likely to affect the immediate course of the AIDS epidemic.

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Interplay between DNA sequence and negative superhelicity drives R-loop structures [Genetics]

R-loops are abundant three-stranded nucleic-acid structures that form in cis during transcription. Experimental evidence suggests that R-loop formation is affected by DNA sequence and topology. However, the exact manner by which these factors interact to determine R-loop susceptibility is unclear. To investigate this, we developed a statistical mechanical equilibrium model…

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Intracellular cargo transport by single-headed kinesin motors [Cell Biology]

Kinesin motor proteins that drive intracellular transport share an overall architecture of two motor domain-containing subunits that dimerize through a coiled-coil stalk. Dimerization allows kinesins to be processive motors, taking many steps along the microtubule track before detaching. However, whether dimerization is required for intracellular transport remains unknown. Here, we…

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Lipoprotein lipase is active as a monomer [Medical Sciences]

Lipoprotein lipase (LPL), the enzyme that hydrolyzes triglycerides in plasma lipoproteins, is assumed to be active only as a homodimer. In support of this idea, several groups have reported that the size of LPL, as measured by density gradient ultracentrifugation, is ∼110 kDa, twice the size of LPL monomers (∼55…

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Divergent kinase regulates membrane ultrastructure of the Toxoplasma parasitophorous vacuole [Microbiology]

Apicomplexan parasites replicate within a protective organelle, called the parasitophorous vacuole (PV). The Toxoplasma gondii PV is filled with a network of tubulated membranes, which are thought to facilitate trafficking of effectors and nutrients. Despite being critical to parasite virulence, there is scant mechanistic understanding of the network’s functions. Here,…

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Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space [Biochemistry]

Over the last two decades, the number of gene/protein sequences gleaned from sequencing projects of individual genomes and environmental DNA has grown exponentially. Only a tiny fraction of these predicted proteins has been experimentally characterized, and the function of most proteins remains hypothetical or only predicted based on sequence similarity….

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Point centromere activity requires an optimal level of centromeric noncoding RNA [Genetics]

In budding yeast, which possesses simple point centromeres, we discovered that all of its centromeres express long noncoding RNAs (cenRNAs), especially in S phase. Induction of cenRNAs coincides with CENP-ACse4 loading time and is dependent on DNA replication. Centromeric transcription is repressed by centromere-binding factor Cbf1 and histone H2A variant…

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Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts [Biophysics and Computational Biology]

Cancer evolution is predominantly studied by focusing on differences in the genetic characteristics of malignant cells within tumors. However, the spatiotemporal dynamics of clonal outgrowth that underlie evolutionary trajectories remain largely unresolved. Here, we sought to unravel the clonal dynamics of colorectal cancer (CRC) expansion in space and time by…

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Biphasic mechanosensitivity of T cell receptor-mediated spreading of lymphocytes [Immunology and Inflammation]

Mechanosensing by T cells through the T cell receptor (TCR) is at the heart of immune recognition. While the mechanobiology of the TCR at the molecular level is increasingly well documented, its link to cell-scale response is poorly understood. Here we explore T cell spreading response as a function of…

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Energy conservation by a hydrogenase-dependent chemiosmotic mechanism in an ancient metabolic pathway [Microbiology]

The ancient reductive acetyl-CoA pathway is employed by acetogenic bacteria to form acetate from inorganic energy sources. Since the central pathway does not gain net ATP by substrate-level phosphorylation, chemolithoautotrophic growth relies on the additional formation of ATP via a chemiosmotic mechanism. Genome analyses indicated that some acetogens only have…

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Evolution of the Pseudomonas aeruginosa quorum-sensing hierarchy [Microbiology]

The bacterial pathogen Pseudomonas aeruginosa activates expression of many virulence genes in a cell density-dependent manner by using an intricate quorum-sensing (QS) network. QS in P. aeruginosa involves two acyl-homoserine-lactone circuits, LasI-LasR and RhlI-RhlR. LasI-LasR is required to activate many genes including those coding for RhlI-RhlR. P. aeruginosa causes chronic…

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Mechanism for autoinhibition and activation of the MORC3 ATPase [Biochemistry]

Microrchidia 3 (MORC3) is a human protein linked to autoimmune disorders, Down syndrome, and cancer. It is a member of a newly identified family of human ATPases with an uncharacterized mechanism of action. Here, we elucidate the molecular basis for inhibition and activation of MORC3. The crystal structure of the…

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Online learning with an almost perfect expert [Computer Sciences]

We study multiclass online learning, where a forecaster predicts a sequence of elements drawn from a finite set using the advice of n experts. Our main contributions are to analyze the scenario where the best expert makes a bounded number b of mistakes and to show that, in the low-error…

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Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3 [Cell Biology]

Mitochondria generate most cellular energy and are targeted by multiple pathogens during infection. In turn, metazoans employ surveillance mechanisms such as the mitochondrial unfolded protein response (UPRmt) to detect and respond to mitochondrial dysfunction as an indicator of infection. The UPRmt is an adaptive transcriptional program regulated by the transcription…

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Crystal structure of human mitochondrial trifunctional protein, a fatty acid {beta}-oxidation metabolon [Biochemistry]

Membrane-bound mitochondrial trifunctional protein (TFP) catalyzes β-oxidation of long chain fatty acyl-CoAs, employing 2-enoyl-CoA hydratase (ECH), 3-hydroxyl-CoA dehydrogenase (HAD), and 3-ketothiolase (KT) activities consecutively. Inherited deficiency of TFP is a recessive genetic disease, manifesting in hypoketotic hypoglycemia, cardiomyopathy, and sudden death. We have determined the crystal

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GSAP modulates {gamma}-secretase specificity by inducing conformational change in PS1 [Neuroscience]

The mechanism by which γ-secretase activating protein (GSAP) regulates γ-secretase activity has not yet been elucidated. Here, we show that knockout of GSAP in cultured cells directly reduces γ-secretase activity for Aβ production, but not for Notch1 cleavage, suggesting that GSAP may induce a conformational change contributing to the specificity…

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Immunization of V{gamma}2V{delta}2 T cells programs sustained effector memory responses that control tuberculosis in nonhuman primates [Microbiology]

Tuberculosis (TB) remains a leading killer among infectious diseases, and a better TB vaccine is urgently needed. The critical components and mechanisms of vaccine-induced protection against Mycobacterium tuberculosis (Mtb) remain incompletely defined. Our previous studies demonstrate that Vγ2Vδ2 T cells specific for (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) phosphoantigen are unique

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Diversifying livestock promotes multidiversity and multifunctionality in managed grasslands [Sustainability Science]

Increasing plant diversity can increase ecosystem functioning, stability, and services in both natural and managed grasslands, but the effects of herbivore diversity, and especially of livestock diversity, remain underexplored. Given that managed grazing is the most extensive land use worldwide, and that land managers can readily change livestock diversity, we…

17h

Processing bodies control the selective translation for optimal development of Arabidopsis young seedlings [Plant Biology]

Germinated plant seeds buried in soil undergo skotomorphogenic development before emergence to reach the light environment. Young seedlings transitioning from dark to light undergo photomorphogenic development. During photomorphogenesis, light alters the transcriptome and enhances the translation of thousands of mRNAs during the dark-to-light transition in Arabidopsis young seedlings. About 1,500.

17h

Cell-free gene-regulatory network engineering with synthetic transcription factors [Biophysics and Computational Biology]

Gene-regulatory networks are ubiquitous in nature and critical for bottom-up engineering of synthetic networks. Transcriptional repression is a fundamental function that can be tuned at the level of DNA, protein, and cooperative protein–protein interactions, necessitating high-throughput experimental approaches for in-depth characterization. Here, we used a cell-free system in combination with…

17h

Organic enantiomeric high-Tc ferroelectrics [Applied Physical Sciences]

For nearly 100 y, homochiral ferroelectrics were basically multicomponent simple organic amine salts and metal coordination compounds. Single-component homochiral organic ferroelectric crystals with high-Curie temperature (Tc) phase transition were very rarely reported, although the first ferroelectric Rochelle salt discovered in 1920 is a homochiral metal coordination compound. Here, we report…

17h

Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host [Microbiology]

Leishmania kinetoplastid parasites infect millions of people worldwide and have a distinct cellular architecture depending on location in the host or vector and specific pathogenicity functions. An invagination of the cell body membrane at the base of the flagellum, the flagellar pocket (FP), is an iconic kinetoplastid feature, and is…

17h

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner [Immunology and Inflammation]

Hemolytic diseases are frequently linked to multiorgan failure subsequent to vascular damage. Deciphering the mechanisms leading to organ injury upon hemolytic event could bring out therapeutic approaches. Complement system activation occurs in hemolytic disorders, such as sickle cell disease, but the pathological relevance and the acquisition of a complement-activating phenotype…

17h

On a two-truths phenomenon in spectral graph clustering [Statistics]

Clustering is concerned with coherently grouping observations without any explicit concept of true groupings. Spectral graph clustering—clustering the vertices of a graph based on their spectral embedding—is commonly approached via K-means (or, more generally, Gaussian mixture model) clustering composed with either Laplacian spectral embedding (LSE) or adjacency spectral embedding (ASE)….

17h

Earlier phenology of a nonnative plant increases impacts on native competitors [Ecology]

Adaptation to climate is expected to increase the performance of invasive species and their community-level impacts. However, while the fitness gains from adaptation should, in general, promote invader competitive ability, empirical demonstrations of this prediction are scarce. Furthermore, climate adaptation, in the form of altered timing of life cycle transitions,…

17h

Regulation of T cell expansion by antigen presentation dynamics [Biophysics and Computational Biology]

An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proliferation must be regulated to ensure an effective response to infection while avoiding immunopathology. Recent experiments in mice have demonstrated that the expansion…

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Human pregnancy zone protein stabilizes misfolded proteins including preeclampsia- and Alzheimer’s-associated amyloid beta peptide [Biochemistry]

Protein misfolding underlies the pathology of a large number of human disorders, many of which are age-related. An exception to this is preeclampsia, a leading cause of pregnancy-associated morbidity and mortality in which misfolded proteins accumulate in body fluids and the placenta. We demonstrate that pregnancy zone protein (PZP), which…

17h

Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory [Neuroscience]

Memory is stored in neural networks via changes in synaptic strength mediated in part by NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). Here we show that a cholecystokinin (CCK)-B receptor (CCKBR) antagonist blocks high-frequency stimulation-induced neocortical LTP, whereas local infusion of CCK induces LTP. CCK−/− mice lacked neocortical LTP and showed…

17h

Mechanisms for achieving high speed and efficiency in biomolecular machines [Evolution]

How does a biomolecular machine achieve high speed at high efficiency? We explore optimization principles using a simple two-state dynamical model. With this model, we establish physical principles—such as the optimal way to distribute free-energy changes and barriers across the machine cycle—and connect them to biological mechanisms. We find that…

17h

Spatially defined molecular emitters coupled to plasmonic nanoparticle arrays [Chemistry]

This paper describes how metal–organic frameworks (MOFs) conformally coated on plasmonic nanoparticle arrays can support exciton–plasmon modes with features resembling strong coupling but that are better understood by a weak coupling model. Thin films of Zn-porphyrin MOFs were assembled by dip coating on arrays of silver nanoparticles (NP@MOF) that sustain…

17h

Array atomic force microscopy for real-time multiparametric analysis [Biophysics and Computational Biology]

Nanoscale multipoint structure–function analysis is essential for deciphering the complexity of multiscale biological and physical systems. Atomic force microscopy (AFM) allows nanoscale structure–function imaging in various operating environments and can be integrated seamlessly with disparate probe-based sensing and manipulation technologies. Conventional AFMs only permit sequential single-point

17h

Regulatory control of Sgs1 and Dna2 during eukaryotic DNA end resection [Biochemistry]

In the repair of DNA double-strand breaks by homologous recombination, the DNA break ends must first be processed into 3′ single-strand DNA overhangs. In budding yeast, end processing requires the helicase Sgs1 (BLM in humans), the nuclease/helicase Dna2, Top3-Rmi1, and replication protein A (RPA). Here, we use single-molecule imaging to…

17h

Selective auxin agonists induce specific AUX/IAA protein degradation to modulate plant development [Plant Biology]

Auxin phytohormones control most aspects of plant development through a complex and interconnected signaling network. In the presence of auxin, AUXIN/INDOLE-3-ACETIC ACID (AUX/IAA) transcriptional repressors are targeted for degradation by the SKP1-CULLIN1-F-BOX (SCF) ubiquitin-protein ligases containing TRANSPORT INHIBITOR RESISTANT 1/AUXIN SIGNALING F-BOX (TIR1/AFB). CULLIN1-neddylation is requi

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Stretchable materials of high toughness and low hysteresis [Engineering]

In materials of all types, hysteresis and toughness are usually correlated. For example, a highly stretchable elastomer or hydrogel of a single polymer network has low hysteresis and low toughness. The single network is commonly toughened by introducing sacrificial bonds, but breaking and possibly reforming the sacrificial bonds causes pronounced…

17h

Applying modern coexistence theory to priority effects [Ecology]

Modern coexistence theory is increasingly used to explain how differences between competing species lead to coexistence versus competitive exclusion. Although research testing this theory has focused on deterministic cases of competitive exclusion, in which the same species always wins, mounting evidence suggests that competitive exclusion is often historically contingent, such…

17h

Light-triggered thermal conductivity switching in azobenzene polymers [Engineering]

Materials that can be switched between low and high thermal conductivity states would advance the control and conversion of thermal energy. Employing in situ time-domain thermoreflectance (TDTR) and in situ synchrotron X-ray scattering, we report a reversible, light-responsive azobenzene polymer that switches between high (0.35 W m−1 K−1) and low…

17h

Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice [Applied Biological Sciences]

Copper is a critical enzyme cofactor in the body but also a potent cellular toxin when intracellularly unbound. Thus, there is a delicate balance of intracellular copper, maintained by a series of complex interactions between the metal and specific copper transport and binding proteins. The gastrointestinal (GI) tract is the…

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Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells, Published online: 09 March 2019; doi:10.1038/s41598-018-37932-6 Author Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of hu

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Team discovers double helix structure in synthetic macromolecule

submitted by /u/lasercat_pow [link] [comments]

19h

Five stories from five years of spaceborne precipitation measurements

On February 27, 2014, a Japanese rocket launched NASA’s latest satellite to advance how scientists study raindrops from space. The satellite, the Global Precipitation Measurement (GPM) Core Observatory, paints a picture of global precipitation every 30 minutes, with help from its other international satellite partners. It has provided innumerable insights into Earth’s precipitation patterns, seve

19h

Bristol project aims to cut plastic waste from takeaways

A project in Bristol is trying to help takeaways solve their plastic container problem.

19h

A Meal Fit for a King

A bitten bone shows how a young tyrannosaur fed. — Read more on ScientificAmerican.com

19h

Precision drugs could unmask cancers to immune system and boost effects of immunotherapy

Precision cancer drugs called PARP inhibitors have a previously unknown ability to boost the immune system, and could help many more patients benefit from immunotherapy, a new study reveals.

19h

What Happens When Galaxies Collide?

Galactic smash-ups can reignite or destroy galaxies — but which will it be? Astronomers using space- and ground-based telescopes to peer inside the mergers of nearby galaxies are hoping to learn more about these events and what they mean for the history and future of our universe. Mergers: Good or Bad? Galaxy mergers have built our universe into the place it is today. Over time, smaller galaxies c

19h

You Should Take Care of Your Lungs, They're Beautifully Complex

Lungs are remarkable organs that continuously achieve amazing feats, which they do so well that we take them for granted, except when their function is diminished. It all happens in a space inside your chest, divided in two and reduced by the presence of the heart, the great vessels and the esophagus. With Supreme Court Justice Ruth Bader Ginsburg having recently returned to the court after surger

19h

The Atlantic Daily: Revisiting the Case for Reparations

What We’re Following U.S. federal education law is overdue for an update —2008 was the last time lawmakers reauthorized the Higher Education Act, making this the longest stretch it’s gone without any tweaks. A lot is at stake , as a potential overhaul of the HEA could help rework the FAFSA (the Free Application for Federal Student Aid), as well as Pell Grants for low-income students, or ease regu

20h

Have 'sexual interludes' obscured the path to love?

We live in a world filled with ghosts. Perhaps you, reader, are among them. Indeed, for many on the hunt for love nowadays, dating is more of spectral phenomenon — A "Now you see me… now you don't" kind of thing — than it is a welcoming home. In America, in particular, — from the sun-scorched, white sand beaches of South Florida to the misty, evergreen woods of Juneau — there are many romantic va

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Citizen Science and March Mammal Madness

The 7th annual March Mammal Madness Tournament (MMM) is upon us! What is MMM, you ask? Only the most engaging, riveting, and scientifically accurate bracket-based tournament around! 82 contenders enter, but only one (or this year, perhaps two) will be the Champion! March Mammal Madness was created in 2013 by Dr. Katie Hinde. Fed up with other March Madness-themed games that relied on popularity or

21h

Crew Dragon Still Faces Crucial Tests Before NASA Certifies it Safe for Astronauts

Now that SpaceX’s Crew Dragon capsule has successfully landed back on Earth and completed its first full test flight, dubbed Demo-1, Elon Musk's rocket company must quickly turn its gaze to the next tests on its journey to put humans in space. SpaceX launched early on March 2, docked with the International Space Station, and returned home Friday morning, splashing down in the Atlantic Ocean at 8:4

21h

Tesla’s Quarter-Megawatt Supercharger Enables Fasts Model 3 Pit Stops

A nearly empty (empty on power) Model 3 may add 100 miles of range in 5 minutes at a SuperCharger 3 refueling station. The post Tesla’s Quarter-Megawatt Supercharger Enables Fasts Model 3 Pit Stops appeared first on ExtremeTech .

21h

SpaceX Crewed Dragon Test Flight Finishes With Perfect Splashdown

The Demo-1 mission successfully splashed-down in the Atlantic Ocean on March 8th, moving the Commercial Crew Program one step closer to flying humans into space. The post SpaceX Crewed Dragon Test Flight Finishes With Perfect Splashdown appeared first on ExtremeTech .

21h

Facebook just made some big privacy promises, and they all hinge on encryption

Technology Tech solutions are important, but so are a company's policies. Encryption is great, but in the world of privacy and security, other factors are important, too.

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A sky full of driverless flying cars in just a decade

submitted by /u/izumi3682 [link] [comments]

21h

The Atlantic Politics & Policy Daily: Shine On

What We’re Following Today It’s Friday, March 8 . ‣ President Donald Trump is visiting Alabama after tornadoes ripped through the state earlier this week, killing 23 people. Trump approved an emergency disaster declaration for the area on Tuesday. ‣ The House passed H.R. 1 , the “For the People Act,” a sweeping bill aimed at cracking down on lobbying, reforming the campaign-finance system, and ex

21h

21h

Oregon Parents Refuse Further Vaccination After Their Child Nearly Dies From Tetanus

It was the first case of tetanus in more than 30 years.

21h

WhiteSmoke uses artificial intelligence to correct your writing mistakes

Save 80 percent on lifetime proofreading. Save 80 percent on lifetime proofreading and get WhiteSmoke. It uses artificial intelligence to correct your writing mistakes.

22h

Is the keto diet safe for everyone? Probably not.

The keto diet might be a fad diet, but it's unique in that involves putting the body into an alternate and natural metabolic state. However, the diet likely isn't safe for everyone, particularly when it's implemented poorly. Children, pregnant women, breastfeeding women and those at risk for heart disease should understand the risks of the keto diet before experimenting with it. None People exper

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Gadget Lab Podcast: Former Googler Jessica Powell On How to Quit Your Tech Job

Former Google communications exec Jessica Powell joins this week’s Gadget Lab podcast to talk about Facebook’s manifestos, quitting Google, and why she absolutely refuses to get a brand-new phone.

22h

SpaceX’s Crew Dragon makes historic landing in Atlantic Ocean

Crew Dragon has successfully completed its six-day mission designed to test whether the capsule is fit to transport humans to the ISS. SpaceX and NASA collaborated on the mission, which signals an end of U.S. reliance on Russian spacecraft to transport astronauts to the space station. Boeing also is working with NASA to execute missions to the space station, and plans to conduct similar tests in

22h

Life-changing learning from Big Think: Be first, be early, be better.

Become a powerhouse thinker and doer. Sign up for Big Think Edge. Experts like Malcolm Gladwell, John Cleese, Sallie Krawcheck, Daniel Kahneman, Gretchen Rubin, Bryan Cranston + more, teach high-value skills that helped them succeed. Sign up now to receive a 20% discount limited to 1,000 early subscribers. None None None None None None Become a better you – personally and professionally Want to b

22h

What Happens Once Robots Become Film Directors?

AI is advancing at exponential rates and taking on increasingly complex tasks. This film, “More Human Than Human” , shows viewers just how far AI has come. The post What Happens Once Robots Become Film Directors? appeared first on Futurism .

22h

Essay: We Broke the Same Bone. My Recovery Was a Breeze, Hers an Ordeal. Why?

Fractures of the fifth metatarsal, in the foot, are common. But doctors treat them in a variety of ways.

22h

No One Is Taking Your Hamburgers. But Would It Even Be a Good Idea?

No, the Green New Deal doesn’t ban beef. And while cutting back on burgers can help your own health and the planet’s, getting rid of cows entirely is another question.

22h

Biologists have studied enzymes that help wheat to fight fungi

Scientists from I.M. Sechenov First Moscow State Medical University together with their Russian colleagues studied reaction of wheat plants to damage caused by pathogenic fungi. They examined activation of enzymes involved in cell death induced in response to infection. The research results and enzyme classification were published in the International Journal of Molecular Sciences.

22h

THOR wrangles complex microbiomes into a model for improving them

Researchers at the University of Wisconsin developed a community they named THOR, three species of bacteria isolated from soybean roots and grown together. The complex community of microbes developed new behaviors together that couldn't be predicted from the individual members alone — they grew tougher structures known as biofilms, changed how they moved across their environment, and controlled t

22h

The Family Weekly: America’s Dark History of Native American Assimilation Schools

(Courtesy of Bad River Historic Preservation Office and Mary Annette Pember) This Week in Family Two hundred years ago this week, Congress passed the Civilization Fund Act of 1819. It marked the start of an official government program that authorized Christian missionaries to set up boarding schools for Native Americans aimed at teaching them “good moral character.” In effect, the policy legalize

22h

Turn On Auto-Updates Everywhere You Can

Meltdowns like the Chrome zero day bug show why enabling auto-updates can be the wisest choice for many consumers.

22h

Seaweed Straw “Looks, Feels, and Acts Like Plastic,” Says Startup

Seaweed Sippers Every day, Americans use an estimated 500 million plastic straws — and the vast majority are ending up in landfills or oceans , where they’ll likely remain for hundreds of years. More and more locations are starting to ban these straws , but rather than asking people to live a straw-less existence, a startup called Loliware thinks we should provide them with an environmentally fri

22h

Zuckerberg Said to Have “Panic Chute” for Escape From Facebook HQ

Panic Chute A Business Insider investigation into Facebook’s security practices provides a riveting look at how the company protects its celebrity executives — but the strangest revelations were about the company’s extraordinary efforts to keep CEO Mark Zuckerberg safe. One persistent rumor exemplifies the company’s apparent paranoia: Workers at the social media giant claim that the company’s sec

22h

Study confirms horseshoe crabs are really relatives of spiders, scorpions

By analyzing troves of genetic data and considering a vast number of possible ways to examine it, University of Wisconsin-Madison scientists now have a high degree of confidence that horseshoe crabs do indeed belong within the arachnids.

22h

Why doesn't the heart shape look like an actual heart?

If our real hearts looked anything like the symbol that represents them, we'd all probably have a much harder time pumping blood through our bodies. The reason why the heart symbol looks nothing like the anatomical heart has its roots, oddly enough, in the economy of a Roman city called Cyrene. Cyrene's heart symbol became associated with love through a strange confluence of botany, philosophy, a

22h

Eyewire Release Report 3/8/2019

Happy Friday! To give you a comprehensive picture of everything new on Eyewire, here are all changes since the last report a few weeks ago. In Live Overview, Scythes who reap while completing will now have their floating icons update to the Scythe shape only once they’ve actually reaped the cube, not just because they entered Inspect Mode. This should allow the Complete icon shape to persist more

23h

Robot Barista, the only vid I found WO cringe inducing background music

submitted by /u/PrestonSteele1 [link] [comments]

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Scientists have chilled tiny electronics to a record low temperature

In a first, electronic chip temperatures dip below a thousandth of a degree kelvin.

23h

Late-blooming exercisers may get the same benefits as lifelong gym rats

Health It’s never too late to get active. If you weren’t active in your youth, it’s easy to feel like you’re starting off at a disadvantage.

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Police Arrest Vandal Who Trashed Tesla Supercharger

Supercharger Vandalism First, pickup truck owners started taking over Supercharger stations in apparent protest . Now a vandal has struck one of Tesla’s electric vehicles chargers. Last week, a 52 year-old man physically vandalized the charging cable and ports at all the docks of a local St. George, Utah’s Tesla Supercharger station, local news reports — the latest skirmish in a simmering culture

23h

LAMP instrument sheds light on lunar water movement

Using the Lyman Alpha Mapping Project (LAMP) aboard NASA's Lunar Reconnaissance Orbiter (LRO), scientists have observed water molecules moving around the dayside of the Moon. A paper describes how LAMP measurements of the atom-thick layer of sparse molecules helped characterize lunar hydration changes over the course of a day.

23h

Illuminating the genome

Researchers have developed a new molecular visualisation method, RNA-guided endonuclease — in situ labelling (RGEN-ISL) for the CRISPR/Cas9-mediated labelling of genomic sequences in nuclei and chromosomes.

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