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nyheder2019november11

Fingerprint test can distinguish between those who have taken or handled heroin

A state-of-the-art fingerprint detection technology can identify traces of heroin on human skin, even after someone has washed their hands — and it is also smart enough to tell whether an individual has used the drug or shaken hands with someone who has handled it.

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Lower IQ, family history tied to treatment-resistant schizophrenia

Those with a family history of schizophrenia and men with lower IQ are more likely to struggle with treatment resistant schizophrenia than others with the mental disorder, according to a new study. The researchers say the findings could be important in efforts to design novel drug treatments that improve cognition.

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Associations between childhood maltreatment and offending behaviors later in life

Children who experience maltreatment, such as neglect or physical or sexual abuse, are more likely to engage in delinquent and offending behaviors in adolescence and young adulthood, according to a new study.

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Women with preeclampsia may be at greater risk for cardiac conditions later in life

Women who have gestational hypertension or preeclampsia in at least one pregnancy will have higher cardiovascular risk than women without such a history, and that this elevated risk persists at least into their 60s.

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Dose of medication more likely to put patients with pemphigus into remission

Researchers compare a lymphoma-dose regimen of rituximab to a rheumatoid arthritis regimen for the treatment of pemphigus.

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Injectable, flexible electrode could replace rigid nerve-stimulating implants

By electrically stimulating nerves, neuromodulation therapies can reduce epileptic seizures, soothe chronic pain, and treat depression and a host of other health conditions without the use of conventional drugs like opioids. Now, biomedical engineers have made a significant advance that could dramatically reduce the cost of neuromodulation therapy, increase its reliability and make it much less in

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Fingerprint test can distinguish between those who have taken or handled heroin

A state-of-the-art fingerprint detection technology can identify traces of heroin on human skin, even after someone has washed their hands — and it is also smart enough to tell whether an individual has used the drug or shaken hands with someone who has handled it.

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New catalyst efficiently produces hydrogen from seawater

Seawater is one of the most abundant resources on earth, offering promise both as a source of hydrogen and of drinking water in arid climates. Now researchers have reported a significant breakthrough with a new oxygen evolution reaction catalyst that, combined with a hydrogen evolution reaction catalyst, achieved current densities capable of supporting industrial demands while requiring relatively

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Injectable, flexible electrode could replace rigid nerve-stimulating implants

By electrically stimulating nerves, neuromodulation therapies can reduce epileptic seizures, soothe chronic pain, and treat depression and a host of other health conditions without the use of conventional drugs like opioids. Now, biomedical engineers have made a significant advance that could dramatically reduce the cost of neuromodulation therapy, increase its reliability and make it much less in

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Google Is Slurping Up Health Data—and It Looks Totally Legal

Tech giants can access all of your personal medical details under existing health privacy laws. The question is how else that data might get used.

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New catalyst efficiently produces hydrogen from seawater

Seawater is one of the most abundant resources on earth, offering promise both as a source of hydrogen and of drinking water in arid climates. Now researchers have reported a significant breakthrough with a new oxygen evolution reaction catalyst that, combined with a hydrogen evolution reaction catalyst, achieved current densities capable of supporting industrial demands while requiring relatively

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New understanding of antibiotic synthesis

Researchers have made important strides in understanding the functioning of enzymes that play an integral role in the production of antibiotics and other therapeutics.

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Scientists study impact of sediments and nutrients from Conowingo Dam on Chesapeake Bay

A new study examines the influences of a river dam on the fate of sediments and nutrients on an estuary, using the Conowingo Dam and the Chesapeake Bay as a case study.

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Anticoagulant benefits for atrial fibrillation decrease with age

The net clinical benefit of anticoagulants for atrial fibrillation (AF) — one of the most important causes of irregular heartbeats and a leading cause of stroke — decreases with age, as the risk of death from other factors diminishes their benefit in older patients, according to a new study.

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What do we know about the gut microbiota in Parkinson's disease?

Since the discovery that the gut microbiome may play a role in the development of Parkinson's disease (PD), this fresh scientific approach has produced varying results. Scientists compare results of current research and provide recommendations to increase the comparability and utility of these studies with a view towards improving patient outcomes.

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Miniature fanged 'deer' rediscovered tiptoeing through Vietnam's coastal forests

Biologists have rediscovered a species lost to science since 1990 called a silver-backed chevrotain — a deer-like species that is the size of a rabbit, has a silver sheen, and has been hanging on in a region of Vietnam ravaged by poaching by snares.

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New particle analysis technique paves way for better air pollution monitoring

A new technique for continuously monitoring both the size and optical properties of individual airborne particles could offer a better way to monitor air pollution.

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Hurricanes have become bigger and more destructive for USA

A new study shows that hurricanes have become more destructive since 1900, and the worst of them are more than 3 times as frequent now than 100 years ago. A new way of calculating the destruction unequivocally shows a climatic increase in the frequency of the most destructive hurricanes that routinely raise havoc on the North American south- and east coast.

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Prey-size plastics are invading larval fish nurseries

Researchers revealed that many larval fish species from different ocean habitats are ingesting plastics in their preferred nursery habitat.

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The Uber CEO's Mistaken Notion of What a Mistake Is

Attention Dara Khosrowshahi: The killing of a woman in Arizona by your company's self-driving car is not a "mistake."

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Embracing failure will help us fund climate-saving technology

submitted by /u/Splenda [link] [comments]

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Lower IQ, family history tied to treatment-resistant schizophrenia

Those with a family history of schizophrenia and men with lower IQ are more likely to struggle with treatment resistant schizophrenia than others with the mental disorder, according to a study by researchers at Karolinska Institutet in Sweden published in the journal Molecular Psychiatry. The researchers say the findings could be important in efforts to design novel drug treatments that improve co

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Arctic Blast Hitting The US Predicted to Break Hundreds of Weather Records

Coldness extremes that have never been documented.

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CRISPR: More than just for gene editing?

Researchers have converted the CRISPR 'recognition induced enzymatic signal' to an electrical signal, which was then used to detect the biomarkers for viruses such as HPV or parvo. They hope the end result could be a new 'universal biosensing' point-of-care medical device — similar to the existing commercial blood-glucose sensor — that rapidly and accurately detects those viruses and more.

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The Atlantic Politics Daily: Rural America Isn't a Monolith

It's Monday, November 11. We're watching: Representative Peter King becomes the 18th GOP House member to forego reelection in 2020. And after a two-year pause, President Trump will announce his picks for the National Medal of Arts—which include one of his biggest fans. In today's newsletter : ❖ Breaking down the tropes of rural America. ❖ Plus , two fascinating family histories that intersect wit

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Ethnic minority women face more barriers to seeing their GP

Women from ethnic minority backgrounds report around twice as many barriers than white women to seeking help for potential cancer symptoms, according to new research funded by Cancer Research UK.

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Use of locum doctors rising despite limited evidence on quality and safety

There is little hard evidence to support the widely held perception that locum doctors present a greater risk of causing harm to patients, according to new research published by the Journal of the Royal Society of Medicine.

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Newborn baby hiccups could be key to brain development

Each time a newborn baby hiccups, it triggers a large wave of brain signals which could help the baby learn how to regulate their breathing, finds a new UCL-led study published in Clinical Neurophysiology.

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Common anti-inflammatory may increase risk of diabetes

A commonly prescribed anti-inflammatory may increase the risk of diabetes after just one week of treatment, according to new findings presented at The Society for Endocrinology Annual Conference. Healthy men given doses of the drug comparable to those used to treat inflammatory disorders had changes in markers of blood sugar metabolism associated with an increased risk of developing diabetes.

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Fingerprint test can distinguish between those who have taken or handled heroin

A state-of-the-art fingerprint detection technology can identify traces of heroin on human skin, even after someone has washed their hands — and it is also smart enough to tell whether an individual has used the drug or shaken hands with someone who has handled it.

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Vitamin B12 deficiency linked to obesity during pregnancy

Vitamin B12 deficiency impairs fat metabolism and may be associated with obesity during pregnancy, according to findings presented at the Society for Endocrinology annual conference. Pregnant women with low levels of vitamin B12 had metabolic markers indicative of increased fat production and reduced breakdown, which suggests that low vitamin B12 levels could predispose pregnant women to obesity.

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New insights into cause and treatments for aggressive form of breast cancer

Potential environmental risk factors and new targets for treating an aggressive form of breast cancer have been identified, according to new data presented at the Society for Endocrinology annual conference in Brighton. The study suggests that exposure to common chemicals in our everyday environment may increase the risk of developing a difficult to treat type of breast cancer and highlights strat

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New fossil pushes back physical evidence of insect pollination to 99 million years ago

A new study co-led by researchers in the U.S. and China has pushed back the first-known physical evidence of insect flower pollination to 99 million years ago, during the mid-Cretaceous period.

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UK teen almost died from severe lung failure linked to vaping

Doctors treating a teenager in the UK for severe lung failure say it was likely caused by an allergic reaction to e-cigarettes

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Middle-aged muscle mass linked to future heart disease risk

The amount of lean muscle a healthy person has in middle age is linked to their future risk of heart disease, suggests research in the Journal of Epidemiology & Community Health.

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Degenerative eye condition (AMD) to affect 77 million Europeans by 2050

The leading cause of irreversible blindness and severely impaired eyesight — age-related macular degeneration, or AMD for short- – is expected to affect 77 million Europeans by 2050, reveal the latest calculations, published online in the British Journal of Ophthalmology.

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Life-threatening lung inflammation linked to vaping in 16-year-old

The fluid in e-cigarettes may cause a potentially life threatening lung inflammation in those who are susceptible, warn doctors in the Archives of Disease in Childhood after treating a teenage boy with respiratory failure linked to vaping.

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A Baby Fish Crisis, the Terrible Microsoft Surface Pro X, and More News

Catch up on the most important news from today in two minutes or less.

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E.P.A. to Limit Science Used to Write Public Health Rules

A new agency rule would restrict the science that can be used in drafting health regulations by requiring researchers to turn over confidential health data.

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Maya Lin to Conjure Dying Trees to Make a Point

Her public art installation at Madison Square Park, opening in June, will focus on the so-called ghost forests that have died off because of climate change.

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Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

Nature, Published online: 12 November 2019; doi:10.1038/s41586-019-1755-5

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Author Correction: Forearc carbon sink reduces long-term volatile recycling into the mantle

Nature, Published online: 12 November 2019; doi:10.1038/s41586-019-1756-4

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Vaping harms more than just your lungs

Most research on e-cigarettes have focused on lung health, but new results show there are also risks to the cardiovascular system. Over the past few months, we've heard a lot about the health impacts of e-cigarettes, but much of the research has focused on the outbreak of acute lung illnesses. The Food and Drug Administration and the Centers for Disease Control continue to actively investigate th

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Can the Shape of Your Face Predict Your Propensity for Violence?

Modern scientists revive a crude form of biological determinism — Read more on ScientificAmerican.com

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How the Nile River Has Stayed In One Place for 30 Million Years

The Nile River seen at sunrise. (Credit: Kirsty Bisset/Shutterstock) Thousands of years ago, ancient Egyptians built their agricultural systems around the dependable movement of the Nile. Those rhythms date back much further than any human relative has been alive, scientists now find. New research shows that the Nile has kept about the same course for its entire 30-million-year existence. This is

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Study investigates a critical transition in water that remains liquid far below 0 °C

The theoretical model proposed by Brazilian researchers can be applied to any system in which two energy scales coexist.

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Women with preeclampsia may be at greater risk for cardiac conditions later in life

Women who have gestational hypertension or preeclampsia in at least one pregnancy will have higher cardiovascular risk than women without such a history, and that this elevated risk persists at least into their 60s.

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Penn uncovers dose of medication more likely to put patients with pemphigus into remission

Researchers from Penn compare a lymphoma-dose regimen of rituximab to a rheumatoid arthritis regimen for the treatment of pemphigus.

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Project to answer last wishes spreads successfully

Six years ago the initial Three Wishes Project began at St. Joseph's Healthcare Hamilton, when hospital staff asked patients or their families how they might honour the life and dignity of those dying in the intensive care unit. Staff would then help families by implementing these wishes. Now a study with three additional hospital intensive care unit sites in Toronto, Vancouver and Los Angeles, Ca

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ACP issues policy recommendations aimed at mitigating the rising costs of prescription drugs

In two new policy papers, the American College of Physicians (ACP) calls for changes aimed at mitigating the rising cost of prescription drugs. The papers provide recommendations to improve transparency in industry and government, examine the role of the Pharmacy Benefit Manager (PBM), and address issues in public health plans that create barriers to care. Both papers are published in Annals of In

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Google Chrome To Call Out Slow-Loading Websites With This New Feature

Google Chrome has been focused on speed since the very beginning, with the browser aiming to open and load pages as fast as possible. Google now wants to let users know when a web page they …

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New understanding of antibiotic synthesis

Researchers at McGill University's Faculty of Medicine have made important strides in understanding the functioning of enzymes that play an integral role in the production of antibiotics and other therapeutics. Their findings are published in Science.

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Scientists study impact of sediments and nutrients from Conowingo Dam on Chesapeake Bay

A new study examines the influences of a river dam on the fate of sediments and nutrients on an estuary, using the Conowingo Dam and the Chesapeake Bay as a case study.

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Study: Where one lives influences post-op care and rehab after hip replacement surgery

A study finds that the socioeconomic status of one's community influences where a patient receives postoperative care and rehabilitation after elective hip replacement surgery. An analysis of a large regional database found that patients in the least affluent communities were more likely to be discharged to an inpatient rehabilitation or skilled nursing facility rather than home care after hip rep

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Silver-Backed Chevrotain, With Fangs And Hooves, Photographed In Wild For First Time

Scientists say their goal was to rediscover a type of chevrotain that had been "lost to science" for nearly 30 years. Chevrotains are the world's smallest hoofed mammal, or ungulate. (Image credit: Southern Institute of Ecology/Global Wildlife Conservation/Leibniz Institute for Zoo and Wildlife Research/NCNP)

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'Ghost' footprints from Pleistocene era revealed by radar tech

Invisible footprints hiding since the end of the last ice age—and what lies beneath them—have been discovered by Cornell University researchers using a special type of radar in a novel way.

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Anders Beich: »Christian Freitag skal da have flere patienter!«

LÆGEDAGE: Differentiering i overenskomsten skal ikke kun handle om økonomi, men også antallet af patienter. Det foreslog Anders Beich, formand i DSAM, da ulighed i sundhed blev vendt under åbningsdebatten ved Lægedage i Bella Center.

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Research brief: Retinal imaging technology for early detection of Alzheimer's disease

Research update from the University of Minnesota Center for Drug Design on an early detection device for Alzheimer's disease.

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Drought-hit Zimbabwe to transfer thousands of animals

Zimbabwe's wildlife agency said Monday it would move hundreds of elephants and other animals in a dramatic bid to save them from a lethal drought.

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Redditor Claims They Fell In Love With OpenAI's Neural Network

Faking It When artificial intelligence startup OpenAI announced the creation of GPT-2 — an algorithm that churns out paragraphs of mostly coherent text in response to a prompt — it warned that people might mistake the AI's output for real news. What they didn't mention was the possibility that someone might mistake its output for real intimacy. But now, a lonely Redditor is claiming that they're

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Researchers find nature's backup plan for converting nitrogen into plant nutrients

Although nitrogen is essential for all living organisms—it makes up 3% of the human body—and comprises 78% of Earth's atmosphere, it's almost ironically difficult for plants and natural systems to access it.

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Drought-hit Zimbabwe to transfer thousands of animals

Zimbabwe's wildlife agency said Monday it would move hundreds of elephants and other animals in a dramatic bid to save them from a lethal drought.

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Mini Mercury skips across sun's vast glare in rare transit

Mini Mercury skipped across the vast, glaring face of the sun Monday in a rare celestial transit.

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Quake widely felt across Hawaii's Big Island, but no damage

A moderate earthquake has been felt across Hawaii's Big Island, but there are no immediate reports of damage.

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New particle analysis technique paves way for better air pollution monitoring

A new technique for continuously monitoring both the size and optical properties of individual airborne particles could offer a better way to monitor air pollution. It is especially promising for analyzing fine particulate matter measuring less than 2.5 microns (PM2.5), which can reach deep into the lungs and cause health problems.

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Det er svært at spotte den sjældne sygdom

Det er vigtigt at kunne finde den sjældne sygdom mellem et utal af velkendte sygdomme, da den kan være forbundet med stor komorbiditet. Men det er en svær disciplin, siger praktiserende læge.

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Hvem varetager allergi hvornår?

Med et stigende antal allergikere er det blevet en større udfordring for den praktiserende læge at vide, hvornår de selv skal varetage patienten, og hvornår de skal viderevisitere. Det vil praktiserende læge gøre op med.

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Apps kan støtte patienter og aflaste læger

Brugen af apps kan klæde patienter på til at tage ansvar for egen behandling og potentielt aflaste lægens arbejde. Men der er brug for politisk opbakning.

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Veterans 'Deprogram' War Through Dance

"Keep your fingers straight and off the trigger. Do not point the rifle at anyone you do not intend to shoot." That's Roman Baca, a U.S. marine and Iraq War veteran. But he's not speaking to the company of soldiers he led during his tour as a sergeant in Fallujah, Iraq . Here, Baca is instructing a company of ballet dancers. In the riveting short documentary Exit 12: Moved by War , directed by Mo

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Google Is Secretly Hoarding Your Medical Records

Google is secretly working with one of the biggest healthcare systems in the U.S. to collect and analyze personal health data from millions of Americans, The Wall Street Journal reports . The megacorporation is reportedly using the data to train machine learning algorithms to suggest changes to individuals' healthcare. It's a far-reaching project that has the potential to threaten the privacy of

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Accelerated evolution of oligodendrocytes in the human brain [Neuroscience]

Recent discussions of human brain evolution have largely focused on increased neuron numbers and changes in their connectivity and expression. However, it is increasingly appreciated that oligodendrocytes play important roles in cognitive function and disease. Whether both cell types follow similar or distinctive evolutionary trajectories is not known. We examined…

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Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice [Medical Sciences]

T cells expressing anti-CD19 chimeric antigen receptors (CARs) demonstrate impressive efficacy in the treatment of systemic B cell malignancies, including B cell lymphoma. However, their effect on primary central nervous system lymphoma (PCNSL) is unknown. Additionally, the detailed cellular dynamics of CAR T cells during their antitumor reaction remain unclear,…

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mRNA structure regulates protein expression through changes in functional half-life [Biophysics and Computational Biology]

Messenger RNAs (mRNAs) encode information in both their primary sequence and their higher order structure. The independent contributions of factors like codon usage and secondary structure to regulating protein expression are difficult to establish as they are often highly correlated in endogenous sequences. Here, we used 2 approaches, global inclusion…

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Superlattice-induced ferroelectricity in charge-ordered La1/3Sr2/3FeO3 [Physics]

Charge-order–driven ferroelectrics are an emerging class of functional materials, distinct from conventional ferroelectrics, where electron-dominated switching can occur at high frequency. Despite their promise, only a few systems exhibiting this behavior have been experimentally realized thus far, motivating the need for new materials. Here, we use density-functional theory to study…

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Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners [Biophysics and Computational Biology]

Histone variants fine-tune transcription, replication, DNA damage repair, and faithful chromosome segregation. Whether and how nucleosome variants encode unique mechanical properties to their cognate chromatin structures remains elusive. Here, using in silico and in vitro nanoindentation methods, extending to in vivo dissections, we report that histone variant nucleosomes are intrinsically…

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A single combination gene therapy treats multiple age-related diseases [Applied Biological Sciences]

Comorbidity is common as age increases, and currently prescribed treatments often ignore the interconnectedness of the involved age-related diseases. The presence of any one such disease usually increases the risk of having others, and new approaches will be more effective at increasing an individual's health span by taking this systems-level…

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RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis [Cell Biology]

Receptor-activity–modifying proteins (RAMPs) are single transmembrane-spanning proteins which serve as molecular chaperones and allosteric modulators of G-protein–coupled receptors (GPCRs) and their signaling pathways. Although RAMPs have been previously studied in the context of their effects on Family B GPCRs, the coevolution of RAMPs with many GPCR families suggests an expanded…

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Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain [Developmental Biology]

Microglia, the resident immune cells of the central nervous system, play an important role in the brain. Microglia have a special spatiotemporal distribution during the development of the cerebral cortex. Neural progenitor cells (NPCs) are the main source of neural-specific cells in the early brain. It is unclear whether NPCs…

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Challenging battles of plants with phloem-feeding insects and prokaryotic pathogens [Plant Biology]

For the past 4 decades, intensive molecular studies of mostly leaf mesophyll cell-infecting pathogens and chewing insects have led to compelling models of plant–pathogen and plant–insect interactions. Yet, some of the most devastating pathogens and insect pests live in or feed on the phloem, a systemic tissue belonging to the…

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Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma [Medical Sciences]

Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to immune-dependent and conventional therapeutic modalities. As a hallmark of glioblastoma (GBM), TAMCs are massively recruited to reach up to 50% of the brain tumor mass. Therefore, they have recently been…

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A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in Drosophila [Microbiology]

Coevolution of viruses and their hosts may lead to viral strategies to avoid, evade, or suppress antiviral immunity. An example is antiviral RNA interference (RNAi) in insects: the host RNAi machinery processes viral double-stranded RNA into small interfering RNAs (siRNAs) to suppress viral replication, whereas insect viruses encode suppressors of…

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An open challenge to advance probabilistic forecasting for dengue epidemics [Medical Sciences]

A wide range of research has promised new tools for forecasting infectious disease dynamics, but little of that research is currently being applied in practice, because tools do not address key public health needs, do not produce probabilistic forecasts, have not been evaluated on external data, or do not provide…

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Distinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakening [Pharmacology]

The majority of patients with insomnia are treated with hypnotic agents. In the present study, we evaluated the side-effect profile of an orexin receptor antagonist and γ-aminobutyric acid A (GABAA) receptor agonist on physical/cognitive functions upon forced awakening. This double-blind, randomized, placebo-controlled, cross-over study was conducted on 30 healthy male…

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Heightened levels and seasonal inversion of riverine suspended sediment in a tropical biodiversity hot spot due to artisanal gold mining [Ecology]

In recent years, rising gold prices have exacerbated the global proliferation of artisanal-scale gold mining (ASGM), with catastrophic consequences for human and ecological health. Much of this burgeoning industry has occurred in biodiversity hot spots, notably in the tropical forests of South America. While the loss of tropical forests and…

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Prey-size plastics are invading larval fish nurseries [Ecology]

Life for many of the world's marine fish begins at the ocean surface. Ocean conditions dictate food availability and govern survivorship, yet little is known about the habitat preferences of larval fish during this highly vulnerable life-history stage. Here we show that surface slicks, a ubiquitous coastal ocean convergence feature,…

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Probing the rice Rubisco-Rubisco activase interaction via subunit heterooligomerization [Biochemistry]

During photosynthesis the AAA+ protein and essential molecular chaperone Rubisco activase (Rca) constantly remodels inhibited active sites of the CO2-fixing enzyme Rubisco (ribulose 1,5-bisphosphate carboxylase/oxygenase) to release tightly bound sugar phosphates. Higher plant Rca is a crop improvement target, but its mechanism remains poorly understood. Here we used structure-guided mutagenesis..

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Unraveling driving forces explaining significant reduction in satellite-inferred Arctic surface albedo since the 1980s [Earth, Atmospheric, and Planetary Sciences]

The Arctic has warmed significantly since the early 1980s and much of this warming can be attributed to the surface albedo feedback. In this study, satellite observations reveal a 1.25 to 1.51% per decade absolute reduction in the Arctic mean surface albedo in spring and summer during 1982 to 2014….

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Feasting yeast and the sweetness of diversity [Commentaries]

The idea that a spreading species can lose genetic diversity goes back to early work by Ernst Mayr in 1942 on founder effects for introduced populations (1). Here, reduced diversity of a spreading population arises from the small number of individuals who are initially introduced into a region (founders). A…

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Correction for Gurrieri et al., Arabidopsis and Chlamydomonas phosphoribulokinase crystal structures complete the redox structural proteome of the Calvin-Benson cycle [Corrections]

PLANT BIOLOGY Correction for "Arabidopsis and Chlamydomonas phosphoribulokinase crystal structures complete the redox structural proteome of the Calvin–Benson cycle," by Libero Gurrieri, Alessandra Del Giudice, Nicola Demitri, Giuseppe Falini, Nicolae Viorel Pavel, Mirko Zaffagnini, Maurizio Polentarutti, Pierre Crozet, Christophe H. Marchand, Julien Henri, Paolo Trost, Stéphane D. Lemaire, France

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Metamaterials with engineered failure load and stiffness [Engineering]

Architected materials or metamaterials have proved to be a very effective way of making materials with unusual mechanical properties. For example, by designing the mesoscale geometry of architected materials, it is possible to obtain extremely high stiffness-to-weight ratio or unusual Poisson's ratio. However, much of this work has focused on…

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The in vivo endothelial cell translatome is highly heterogeneous across vascular beds [Genetics]

Endothelial cells (ECs) are highly specialized across vascular beds. However, given their interspersed anatomic distribution, comprehensive characterization of the molecular basis for this heterogeneity in vivo has been limited. By applying endothelial-specific translating ribosome affinity purification (EC-TRAP) combined with high-throughput RNA sequencing analysis, we identified pan EC-enriched

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Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation [Biochemistry]

Viruses have transformed our understanding of mammalian RNA processing, including facilitating the discovery of the methyl-7-guanosine (m7G) cap on the 5′ end of RNAs. The m7G cap is required for RNAs to bind the eukaryotic translation initiation factor eIF4E and associate with the translation machinery across plant and animal kingdoms….

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Pollination of Cretaceous flowers [Evolution]

Insect pollination of flowering plants (angiosperms) is responsible for the majority of the world's flowering plant diversity and is key to the Cretaceous radiation of angiosperms. Although both insects and angiosperms were common by the mid-Cretaceous, direct fossil evidence of insect pollination is lacking. Direct evidence of Cretaceous insect pollination…

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Correction for Chen et al., Sugar starvation-regulated MYBS2 and 14-3-3 protein interactions enhance plant growth, stress tolerance, and grain weight in rice [Corrections]

PLANT BIOLOGY Correction for "Sugar starvation-regulated MYBS2 and 14-3-3 protein interactions enhance plant growth, stress tolerance, and grain weight in rice," by Yi-Shih Chen, Tuan-Hua David Ho, Lihong Liu, Ding Hua Lee, Chun-Hua Lee, Yi-Ru Chen, Shu-Yu Lin, Chung-An Lu, and Su-May Yu, which was first published October 8, 2019;…

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Correction for Huet et al., Capsid expansion of bacteriophage T5 revealed by high resolution cryoelectron microscopy [Corrections]

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for "Capsid expansion of bacteriophage T5 revealed by high resolution cryoelectron microscopy," by Alexis Huet, Robert L. Duda, Pascale Boulanger, and James F. Conway, which was first published October 2, 2019; 10.1073/pnas.1909645116 (Proc. Natl. Acad. Sci. U.S.A. 116, 21037–21046). The authors note that, due to…

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Quantification of the resilience of primary care networks by stress testing the health care system [Social Sciences]

There are practically no quantitative tools for understanding how much stress a health care system can absorb before it loses its ability to provide care. We propose to measure the resilience of health care systems with respect to changes in the density of primary care providers. We develop a computational…

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Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude [Anthropology]

Highland native Andeans have resided at altitude for millennia. They display high aerobic capacity (VO2max) at altitude, which may be a reflection of genetic adaptation to hypoxia. Previous genomewide (GW) scans for natural selection have nominated Egl-9 homolog 1 gene (EGLN1) as a candidate gene. The encoded protein, EGLN1/PHD2, is…

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Solvent fluctuations in the solvation shell determine the activation barrier for crystal growth rates [Engineering]

Solution crystallization is a common technique to grow advanced, functional crystalline materials. Supersaturation, temperature, and solvent composition are known to influence the growth rates and thereby properties of crystalline materials; however, a satisfactory explanation of how these factors affect the activation barrier for growth rates has not been developed. We…

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Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB [Evolution]

PdxB (erythronate 4-phosphate dehydrogenase) is expected to be required for synthesis of the essential cofactor pyridoxal 5′-phosphate (PLP) in Escherichia coli. Surprisingly, incubation of the ∆pdxB strain in medium containing glucose as a sole carbon source for 10 d resulted in visible turbidity, suggesting that PLP is being produced by…

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WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells [Cell Biology]

WEE1 kinase is a key regulator of the G2/M transition. The WEE1 kinase inhibitor AZD1775 (WEE1i) induces origin firing in replicating cells. We show that WEE1i induces CDK1-dependent RIF1 phosphorylation and CDK2- and CDC7-dependent activation of the replicative helicase. WEE1 suppresses CDK1 and CDK2 kinase activities to regulate the G1/S…

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Elovanoids counteract oligomeric {beta}-amyloid-induced gene expression and protect photoreceptors [Neuroscience]

The onset of neurodegenerative diseases activates inflammation that leads to progressive neuronal cell death and impairments in cognition (Alzheimer's disease) and sight (age-related macular degeneration [AMD]). How neuroinflammation can be counteracted is not known. In AMD, amyloid β-peptide (Aβ) accumulates in subretinal drusen. In the 5xFAD retina, we found early…

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Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1 [Medical Sciences]

p53 is the most frequently mutated gene in human cancers and mutant p53 has a gain of function (GOF) that promotes tumor progression and therapeutic resistance. One of the major GOF activities of mutant p53 is to suppress 2 other p53 family proteins, p63 and p73. However, the molecular basis…

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Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration [Cell Biology]

The human retinal pigment epithelium (RPE) and choroid are complex tissues that provide crucial support to the retina. Disease affecting either of these supportive tissues can lead to irreversible blindness in the setting of age-related macular degeneration. In this study, single-cell RNA sequencing was performed on macular and peripheral regions…

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QnAs with Sheng Yang He [QnAs]

Sheng Yang He has spent a distinguished career studying bacterial plant pathogens and the molecular mechanisms by which they lead to disease. A professor of plant biology at Michigan State University and a Howard Hughes Medical Institute investigator, He was elected to the National Academy of Sciences in 2015. He…

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Normalized US hurricane damage estimates using area of total destruction, 1900-2018 [Economic Sciences]

Hurricanes are the most destructive natural disasters in the United States. The record of economic damage from hurricanes shows a steep positive trend dominated by increases in wealth. It is necessary to account for temporal changes in exposed wealth, in a process called normalization, before we can compare the destructiveness…

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Multistable properties of human subthalamic nucleus neurons in Parkinson's disease [Neuroscience]

To understand the function and dysfunction of neural circuits, it is necessary to understand the properties of the neurons participating in the behavior, the connectivity between these neurons, and the neuromodulatory status of the circuits at the time they are producing the behavior. Such knowledge of human neural circuits is…

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Introgression drives repeated evolution of winter coat color polymorphism in hares [Evolution]

Changing from summer-brown to winter-white pelage or plumage is a crucial adaptation to seasonal snow in more than 20 mammal and bird species. Many of these species maintain nonwhite winter morphs, locally adapted to less snowy conditions, which may have evolved independently. Mountain hares (Lepus timidus) from Fennoscandia were introduced…

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Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering [Biochemistry]

Coat protein I (COPI)-coated vesicles mediate retrograde transport from the Golgi to the endoplasmic reticulum (ER), as well as transport within the Golgi. Major progress has been made in defining the structure of COPI coats, in vitro and in vivo, at resolutions as high as 9 Å. Nevertheless, important questions…

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Hepatocyte nuclear factor-1{beta} regulates Wnt signaling through genome-wide competition with {beta}-catenin/lymphoid enhancer binding factor [Developmental Biology]

Hepatocyte nuclear factor-1β (HNF-1β) is a tissue-specific transcription factor that is essential for normal kidney development and renal tubular function. Mutations of HNF-1β produce cystic kidney disease, a phenotype associated with deregulation of canonical (β-catenin–dependent) Wnt signaling. Here, we show that ablation of HNF-1β in mIMCD3 renal epithelial cells produces…

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Pubertal stress recalibration reverses the effects of early life stress in postinstitutionalized children [Physiology]

Nonhuman animal models reveal that the hypothalamic–pituitary–adrenocortical (HPA) axis calibrates to the harshness of the environment during a sensitive period in infancy. Humans exposed to depriving institutional care in infancy show reduced HPA axis responsivity, even years after they are placed in supportive, well-resourced families. This study examined whether puberty…

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Parallel evolution of ancient, pleiotropic enhancers underlies butterfly wing pattern mimicry [Evolution]

Color pattern mimicry in Heliconius butterflies is a classic case study of complex trait adaptation via selection on a few large effect genes. Association studies have linked color pattern variation to a handful of noncoding regions, yet the presumptive cis-regulatory elements (CREs) that control color patterning remain unknown. Here we…

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T6SS and ExoA of flesh-eating Aeromonas hydrophila in peritonitis and necrotizing fasciitis during mono- and polymicrobial infections [Cell Biology]

An earlier report described a human case of necrotizing fasciitis (NF) caused by mixed infection with 4 Aeromonas hydrophila strains (NF1–NF4). While the NF2, NF3, and NF4 strains were clonal and possessed exotoxin A (ExoA), the NF1 strain was determined to be phylogenetically distinct, harboring a unique type 6 secretion…

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Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures [Microbiology]

Sporadic colorectal cancer (CRC) is a result of complex interactions between the host and its environment. Environmental stressors act by causing host cell DNA alterations implicated in the onset of cancer. Here we investigate the stressor ability of CRC-associated gut dysbiosis as causal agent of host DNA alterations. The epigenetic…

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AI-generated fake content could unleash a virtual arms race

submitted by /u/transtwin [link] [comments]

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What will designer babies look like in the future?

submitted by /u/EcstadelicNET [link] [comments]

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[Serious] Does a post-ownership future seem scary or unrealistic to you?

I've seen discussions on here about a post-ownership society and other articles online about it, but how many of you genuinely think such a future is either scary or unrealistic? Could you imagine not owning anything – whether it be the clothes in your wardrobe, your car ( as a car enthusiast, the thought of future with no car ownership and it being verboten does seem slightly frightening and wor

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How to visit 10,000 stars in a million years: electrical sails.

submitted by /u/OliverSparrow [link] [comments]

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Testing 9 New Mini Cheetahs

submitted by /u/izumi3682 [link] [comments]

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Researchers find nature's backup plan for converting nitrogen into plant nutrients

Princeton University researchers have found that nature has developed a backup method for converting atmospheric nitrogen into the nutrient form critical to plant growth and soil fertility. The researchers report that the process known as nitrogen fixation can be carried out by the metal vanadium in ecosystems where the primary catalyst molybdenum is scarce. The study suggests that nature's capaci

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HSS experts share best practices for developing and implementing educational programs

At the 2019 ACR annual meeting in Atlanta, experts from the HSS Education Institute at Hospital for Special Surgery (HSS) presented their method for developing and implementing effective educational programs for diverse patients with rheumatic conditions.

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Finding common ground for scientists and policymakers on soil carbon and climate change

There is growing interest in the potential for soil carbon to mitigate climate change, brought into the public sphere at the 2015 United Nations Climate Change Conference (COP21) in Paris. France. There, the French government launched an international initiative, "4per1000," aimed at reducing greenhouse gas emissions by building soil carbon.

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How India's local recyclers could solve plastic pollution | Mani Vajipey

India has one of the world's highest rates of plastic recycling, thanks largely to an extensive network of informal recyclers known as "kabadiwalas." Entrepreneur Mani Vajipey discusses his work to organize their massive efforts into a collection system that could put India on the path to ending plastic pollution — and show the rest of the world how to do it, too.

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Climate change: Bigger hurricanes are now more damaging

The most damaging tropical cyclones are three times more frequent now than they were 100 years ago.

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New fossil pushes back physical evidence of insect pollination to 99 million years ago

Researchers have pushed back the first-known physical evidence of insect flower pollination to 99 million years ago, during the mid-Cretaceous period.

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Finding common ground for scientists and policymakers on soil carbon and climate change

Scientists argue that public debate about the role of soil carbon in battling climate change is undermining the potential for policymakers to implement policies that build soil carbon for other environmental and agricultural benefits.

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How two strains of one bacterium combine to cause flesh-eating infection

A new study used genetic analysis to reveal how two different strains of a single species of flesh-eating bacteria worked in concert to become more dangerous than either one strain alone. The work suggests that other difficult-to-treat infections may be polymicrobial and treating only one organism in a polymicrobial infection could be the cause of many secondary infections and chronic infections t

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'Ghost' footprints from Pleistocene era revealed by radar tech

Invisible footprints hiding since the end of the last ice age—and what lies beneath them—have been discovered by Cornell University researchers using a special type of radar in a novel way.

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How Crime Scene Analysts Collect and Preserve Fingerprints

A veteran analyst explains the work of gathering fingerprints that can link a suspect to a crime—even after it rains.

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How Many People Have to Die Before We're Done With Gender Reveals?

At least one human life has already been lost as a direct result of the widespread obsession with turning the sex of one's unborn child into an explosive (often literally) spectacle. In October, an Iowa woman was killed when her family inadvertently built a pipe bomb as part of their gender-reveal party—a gathering at which expectant parents dramatically and colorfully announce the sex of their b

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Powerful blenders for nutrient-packed smoothies, soups, and sauces

Love is blend. (Element5 Digital via Unsplash/) Eating blended fruits and vegetables allows you to digest all the nutrients and fibers that can be difficult to eat or digest. This is why so many active and healthy people swear by drinking smoothies every day. Of course, buying smoothies at a juice bar is expensive, and you can't guarantee you're getting the freshest ingredients. So why leave the

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New particle analysis technique paves way for better air pollution monitoring

A new technique for continuously monitoring both the size and optical properties of individual airborne particles could offer a better way to monitor air pollution.

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Olfactory Attraction and Smell Dating

Smell Dating , an interactive exhibit by Tega Brain and Sam Lavigne at The Glass Room . A conceptual art installation, an extended olfactory performance piece, an elaborate participatory project , or an actual smell-based dating service? Smell Dating is all of these and more! How it works We send you a t-shirt You wear the shirt for three days and three nights without deodorant. You return the sh

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'Ghost' footprints from Pleistocene era revealed by radar tech

Invisible footprints hiding since the end of the last ice age — and what lies beneath them — have been discovered by researchers using a special type of radar in a novel way.

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Scientists find eternal Nile to be more ancient than previously thought

The Nile's unchanging path has been a geologic mystery because long-lived rivers usually move over time. Researchers have cracked the case by linking the river's flow to the movement of rock in the Earth's deep mantle. In the course of their investigation, they found the age of the Nile to be 30 million years — about six times as long as previously thought.

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Using mountains for long-term energy storage

The storage of energy for long periods of time is subject to special challenges. A researcher proposes using a combination of Mountain Gravity Energy Storage (MGES) and hydropower as a solution for this issue.

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Oxygen deficiency rewires mitochondria

Mitochondria burn oxygen and provide energy for the body. Cells lacking oxygen or nutrients have to change their energy supply quickly in order to keep growing. Scientists have now shown that mitochondria are reprogrammed under depleted oxygen and nutrients. Tumors of the pancreas may also use this reprogramming mechanism to keep growing despite reduced nutrient and oxygen levels. The researchers

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The pathway to Parkinson's takes a surprising twist

A new study finds that neurons affected in Parkinson's disease can shut down without fully dying, allowing them to also switch off neighboring cells. The findings might give scientists a better understanding of how the condition wrecks havoc in the brain, as well as ideas for new treatments.

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The Slow-Boil Revolt

Here is the unenviable calculation retired senior military officials must make in this politically unprecedented moment: Say nothing as norms shatter around you, and you're implicitly enabling a president who some of your former colleagues believe is threatening national security. Speak up, and you risk destroying the balance of power that protects American democracy. "For the U.S. military, bein

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More than half of males with lupus report feeling depressed, receive little support

HSS launched a nationwide survey to assess the needs of males with lupus. The researchers found that the illness has a significant impact on patients' physical and emotional health, yet they often do not receive support that could help them cope. More than 80% of respondents indicated that lupus limited their activities of daily living, mainly due to pain and fatigue.

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Wide-ranging gender disparities remain in pediatrics

Three commonly argued justifications for the persistent discrimination and gender bias that prevent women from rising to leadership positions in the field of pediatric medicine have been debunked by a Drexel University College of Medicine researcher and colleagues in a special article published in the November 2019 issue of the journal Pediatrics.

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Gold mining critically impairs water quality in rivers across Peruvian biodiversity hotspot

A Dartmouth study published in the Proceedings of the National Academy of Sciences finds that artisanal-scale gold mining is altering water clarity and dynamics in the Madre de Dios River watershed in Peru, a tropical biodiversity hotspot. Higher levels of suspended sediment were found in rivers near the mining sites. The elevated sediment levels contain mercury and other contaminants, which can p

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Prey-size plastics are invading larval fish nurseries

A new study by researchers at Arizona State University's Center for Global Discovery and Conservation Science (GDCS) and NOAA's Pacific Islands Fisheries Science Center has revealed that larval fish species from various ocean habitats are now being threatened by plastic pollution that infects their nursery habitats—at levels on average, eight times higher than those recently found in the Great P

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New fossil pushes back physical evidence of insect pollination to 99 million years ago

A study co-led by researchers at Indiana University and the Chinese Academy of Sciences has pushed back the first-known physical evidence of insect flower pollination to 99 million years ago, during the mid-Cretaceous period.

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Team plucks needle from genomic haystack, finding essential transcription factor binding sites

Using CRISPR/Cas9 knockout screens, a multi-institutional research team systematically interrogated the essentiality of more than 10,000 forkhead box protein A1 (FOXA1) and CTCF binding sites in breast and prostate cancer cells, finding that essential FOXA1 binding sites act as enhancers to orchestrate the expression of nearby essential genes.

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Understanding how strains of flesh-eating bacteria interact may be key to treatment

A new study from The University of Texas Medical Branch at Galveston performed in collaboration with the University of Maryland at College Park investigated the dynamics among these strains, which may lead to the development of new therapeutic interventions. The study is currently available in Proceedings of the National Academy of Sciences.

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Earliest evidence of insect-angiosperm pollination found in Cretaceous Burmese amber

Most of our food is from angiosperms, while more than 90% of angiosperms require insect pollination – making this pollination method hugely important. Nevertheless, scientists have long been unclear as to when insect pollination first appeared. Now, however, an international research group from China and the US has provided the earliest evidence of insect-angiosperm pollination — by analyzing a s

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Forecasting dengue: Challenges and a way forward

International collaboration is finding new ways to improve how scientists develop and test models to forecast dengue infection.

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New research explains how HIV avoids getting ZAPped

Humans have evolved dynamic defense mechanisms against the viruses that seek to infect our bodies — proteins that specialize in identifying, capturing and destroying the genetic material that viruses try to sneak into our cells.

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LSU Health research discovers potential new Rx target for AMD and Alzheimer's

Research led by Nicolas Bazan, M.D., Ph.D., Boyd Professor and Director of the Neuroscience Center of Excellence at LSU Health New Orleans School of Medicine, found a new mechanism by which a class of molecules his lab discovered may protect brain and retinal cells against neurodegenerative diseases like age-related macular degeneration and Alzheimer's.

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Stress testing the healthcare system

Austrian scientists can for the first time determine the resilience of the health care system in a region. Their model provides concrete answers to stakeholder questions such as: how important is a certain doctor for the functioning of primary care in my region? How many and which doctors' retirements can the system absorb? At what point can primary health care no longer be guaranteed for everyone

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Salmonella — how the body fights back

New research shows how our immune system fights back against Salmonella infection. A new study reveals how blood stem cells respond in the first few hours following infection — by acquiring energy from bone marrow support cells. It is hoped that the findings could help form new approaches to treating people with Salmonella and other bacterial illnesses.

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Prey-size plastics are invading larval fish nurseries

Larval fish of different fish species and ocean habitats are surrounded by and ingesting plastics in their preferred nursery habitat. Many of the world's marine fish spend their first days or weeks feeding and developing at the ocean surface. Unfortunately, new research has found that the same ocean processes that aggregate prey for larval fish also concentrated buoyant, passively floating plastic

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Hurricanes have become bigger and more destructive for USA; new study from the Niels Bohr Institute

A new study by researchers at the Niels Bohr Institute, University of Copenhagen, Aslak Grinsted, Peter Ditlevsen and Jens Hesselbjerg shows that hurricanes have become more destructive since 1900, and the worst of them are more than 3 times as frequent now than 100 years ago. A new way of calculating the destruction unequivocally shows a climatic increase in the frequency of the most destructive

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Prey-size plastics are invading larval fish nurseries

In a study to be published in the Proceedings of the National Academy of Sciences, researchers revealed that many larval fish species from different ocean habitats are ingesting plastics in their preferred nursery habitat.

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Study reveals how two strains of one bacterium combine to cause flesh-eating infection

A new study published in the Proceedings of the National Academy of Sciences used genetic analysis to reveal how two different strains of a single species of flesh-eating bacteria worked in concert to become more dangerous than either one strain alone. The work suggests that other difficult-to-treat infections may be polymicrobial and treating only one organism in a polymicrobial infection could b

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Diet, body clock, hormones, and metabolism: What's the link?

A new study of mice has shown how stress hormones control fat and sugar levels in a time dependent way and how a high calorie diet can alter this rhythm.

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A Satellite That Fires Fake Shooting Stars Is Ready to Launch

Night Light Astro Live Experiences, the company that wants to illuminate the night sky with artificial shooting stars , is nearly ready for its cosmic debut. The tiny satellite, ALE-2, will be launched into orbit on November 25, according to Space.com . After that, the company will run a few final tests before preparing for its first fake meteor shower in 2020. In other words, if all goes well, t

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Tiny magnetic building blocks are quadrupolar

An external magnetic field controls new cube-shaped magnetic building blocks that can form 2D shapes. If you've ever tried to put several really strong, small cube magnets right next to each other on a magnetic board, you'll know that you just can't do it. The magnets always arrange themselves in a column sticking out vertically from the magnetic board. Moreover, it's almost impossible to join se

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'Eater cells' may prevent even worse damage after heart attack

Boosting the activity of specific immune cells in the heart after a heart attack can protect against developing heart failure, according to research with mice. Patients with heart failure, an invariably fatal condition, tire easily and become breathless from everyday activities because the heart muscle has lost the ability to pump enough blood to the body. The study could lead to new therapies th

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150 Years of the Journal Nature

Nature is arguably the world's most prestigious scientific journal. Editor in chief Magdalena Skipper spoke with Scientific American's acting editor in chief Curtis Brainard about her… — Read more on ScientificAmerican.com

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Flesh-eating infection caused by two microbe strains discovered by doctors

Infection found in patient who required quadruple amputation after developing rare condition Doctors have discovered an aggressive flesh-eating infection that spreads around the body when two strains of microbe combine to overcome the host's defences. The infection was found in a patient who required a quadruple amputation after they developed necrotising fasciitis, a rare bacterial condition tha

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Fremtiden er digital

Elektronik er allerede en fast integreret del af lægepraksisserne, men i fremtiden vil en endnu større del af lægens arbejde være båret af IT. Elektronikken kan hjælpe lægen i det daglige arbejde, siger næstformand i PLO.

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Ice loss causing Arctic to reflect less heat

A loss of snow and ice cover are the main reasons for the reduction of the Arctic's albedo effect, not soot as had been previously thought.

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Paper Used in Creationist Teaching Retracted After 30 Years

Criticism of the paper first surfaced in 1994, and its author was accused of scientific misconduct.

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This amber-encased beetle may have been one of the first insects to pollinate flowers

Find pushes insect pollination back nearly 50 million years

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Baby Fish Feast on Microplastics, and Then Get Eaten

Fish larvae off the coast of Hawaii are mistaking tiny pieces of plastic for prey, an alarming finding with big implications for the oceanic food web.

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Meditation can help you make fewer mistakes

Here's some good news if you tend to make mistakes or are forgetful when in a hurry: Meditation may offer a way to make you less error-prone, researchers report. The researchers tested how open monitoring meditation—meditation that focuses awareness on feelings, thoughts, or sensations as they unfold in one's mind and body—altered brain activity in a way that suggests increased error recognition.

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Infant home visiting program linked to less child abuse

Family Connects, a nurse home visiting program for newborns and their parents, is linked to substantial reductions in child maltreatment investigations in children's earliest years, according to new research from Duke University. Program participants had 44 percent lower rates of child maltreatment investigations during children's first 24 months of life, compared with parents who did not receive

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Study reveals how two strains of one bacterium combine to cause flesh-eating infection

In recent years, scientists have found that serious infections that progress rapidly and resist treatment are often caused by multiple microbes interacting with one another. Very little is known about these so-called polymicrobial infections, but traditional diagnostic methods often misidentify them as monomicrobial, or single-microbe, infections.

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New research explains how HIV avoids getting ZAPped

Humans have evolved dynamic defense mechanisms against the viruses that seek to infect our bodies—proteins that specialize in identifying, capturing and destroying the genetic material that viruses try to sneak into our cells.

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Prey-size plastics are invading larval fish nurseries

New research shows that many larval fish species from different ocean habitats are ingesting plastics in their preferred nursery habitat.

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Gold mining critically impairs water quality in rivers across Peruvian biodiversity hotspot

A Dartmouth study finds that artisanal-scale gold mining is altering water clarity and dynamics in the Madre de Dios River watershed in Peru, a tropical biodiversity hotspot. Higher levels of suspended sediment were found in rivers near the mining sites, with increasing impacts as mining has become more widespread in the past two decades. The elevated sediment levels contain mercury and other cont

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Study reveals how two strains of one bacterium combine to cause flesh-eating infection

In recent years, scientists have found that serious infections that progress rapidly and resist treatment are often caused by multiple microbes interacting with one another. Very little is known about these so-called polymicrobial infections, but traditional diagnostic methods often misidentify them as monomicrobial, or single-microbe, infections.

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New research explains how HIV avoids getting ZAPped

Humans have evolved dynamic defense mechanisms against the viruses that seek to infect our bodies—proteins that specialize in identifying, capturing and destroying the genetic material that viruses try to sneak into our cells.

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Prey-size plastics are invading larval fish nurseries

New research shows that many larval fish species from different ocean habitats are ingesting plastics in their preferred nursery habitat.

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New fossil pushes back physical evidence of insect pollination to 99 million years ago

A new study co-led by researchers in the U.S. and China has pushed back the first-known physical evidence of insect flower pollination to 99 million years ago, during the mid-Cretaceous period.

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Hurricanes have become bigger and more destructive for the U.S., study finds

A new study by researchers at the Niels Bohr Institute, University of Copenhagen, Aslak Grinsted, Peter Ditlevsen and Jens Hesselbjerg shows that hurricanes have become more destructive since 1900, and the worst of them are more than three times as frequent now than 100 years ago. A new way of calculating the destruction, compensating for the societal change in wealth, unequivocally shows a climat

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How Big Is the Proton? Particle-Size Puzzle Leaps Closer to Resolution

Precise measurement affirms that the particle's radius is smaller than physicists once thought — Read more on ScientificAmerican.com

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An Arctic blast is headed our way this week, and it's earlier than usual

Frosty air from the upper latitudes will bring uncharacteristically cool weather to two-thirds of the US. It's officially puffy parka time for much of the US. A "blast" of chilly Arctic air is expected to pass over the eastern part of the country this week, bringing piles of snow from the Great Lakes to New England. The mercury will drop 15 to 25 degrees Fahrenheit below average, breaking a few r

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Why I'm not applying for promotion

Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03487-3 Phill Cassey outlines one proactive step to support diversity in his workplace.

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Meet 5-MeO-DMT, the 'powerful' psychedelic that improves depression in one hour

A survey study found that around 80 percent of people using the psychedelic 5-MeO-DMT in a ceremonial setting said that their depression or anxiety improved following its use. The "mystical" experience of drug trip might allow people to gain unique insight into themselves or their relationships and make positive life changes. While substance is found in the poison of the Sonoran Desert Toad, rese

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Cholesterol levels in American adults declining since 2013 guideline release

The implementation of the 2013 American College of Cardiology/American Heart Association Guideline on the Treatment of Blood Cholesterol has been linked to improved overall cholesterol levels for American adults, especially those on cholesterol lowering medications, according to a new study.

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Biomarker blood test could reveal high risk heart patients in need of treatment

Preventive cardiology researchers believe that a new blood test for protein biomarkers could identify early stage heart disease in people.

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Evolutionary diversity is associated with Amazon forest productivity

An international team of researchers have revealed for the first time that Amazon forests with the greatest evolutionary diversity are the most productive.

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A cheaper way to scale up atomic layer deposition

Chemical engineers have developed a new method for atomic layer deposition, a technique commonly used in high-quality microelectronics. The new method can be used in materials with larger surfaces much more cheaply than current approaches, while preserving quality and efficiency.

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Large scale integrated circuits produced in printing press

Researchers have shown for the first time that it is possible to print complete integrated circuits with more than 100 organic electrochemical transistors.

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Scientists map mouse personality

Scientists have developed a computational method to objectively measure the personality of mice living in a semi-natural, group environment.

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Combining satellites, radar provides path for better forecasts

Every minute counts when it comes to predicting severe weather. Combing data from cutting-edge geostationary satellites and traditional weather radar created a path toward earlier, more accurate warnings, according to researchers who studied supercell thuderstorms in the Midwest.

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How meditation can help you make fewer mistakes

New research tested how open monitoring meditation altered brain activity in a way that suggests increased error recognition.

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Ebola Vaccine Approved for Use in Europe

Merck's Ervebo gets its first regulatory greenlight. A decision from the US Food and Drug Administration is expected in the next few months.

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Google Reportedly Amassed Private Health Data on Millions of People Without Their Knowledge

Google has tapped a partnership with a prominent healthcare services company to advance its healthcare software services offerings. But a new report alleges the data being used for the project …

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The Magic of Fall Colors

As the season progresses toward chillier days and nights, I thought it would be nice to take one last look at the colorful beauty of this autumn, seen in cities and countryside vistas across the Northern Hemisphere. Bundle up, maybe grab a mug of hot cider, and enjoy this batch of recent fall photos. For even more autumnal goodness, check out " Images of the Season " from earlier this year.

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Australia unprepared to move future Alzheimer's treatment into rapid clinical use

Much work has been done to try to find a treatment that can delay or prevent the onset of Alzheimer's disease, but less attention has been paid to whether health systems could move a breakthrough into rapid clinical use. A new study finds that while Australia is better prepared than many other countries for such a development, there are steps policymakers may consider to better prepare the nation'

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The gut may be the ticket to reducing chemo's side effects

In a new study, scientists observed several simultaneous reactions in mice given a common chemotherapy drug: Their gut bacteria and tissue changed, their blood and brains showed signs of inflammation, and their behaviors suggested they were fatigued and cognitively impaired.

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'Ghost' footprints from Pleistocene era revealed by radar tech

Invisible footprints hiding since the end of the last ice age — and what lies beneath them — have been discovered by Cornell University researchers using a special type of radar in a novel way.

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Finding common ground for scientists and policymakers on soil carbon and climate change

In an opinion published in Nature Sustainability, a group of scientists argue that public debate about the role of soil carbon in battling climate change is undermining the potential for policymakers to implement policies that build soil carbon for other environmental and agricultural benefits.

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Sophia the Robot Says She Doesn't Have Sex, Confusing Creators

Going Off-Script Last week, world-famous robot Sophia shared with the crowd at the 2019 Web Summit that she — or it, or whatever — doesn't have sex . Now, Amit Kumar Pundley, president and CTO of Hanson Robotics, the company that built Sophia, told Futurism that the bizarre revelation was not a scripted piece of dialogue. In fact, an internal investigation revealed that the humanoid robot seemed

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Late talkers twice as likely to have severe, frequent temper tantrums

Toddler speech delays and temper tantrums have long been assumed to be linked. Now, for the first time, a new, large-scale study supports that assumption with data.

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The Date Hong Kong Protesters Can't Escape

HONG KONG—It was after one of the many pro-democracy protests here this year that the filmmaker Jevons Au, having been engulfed in tear gas, beaten with a police truncheon, and run for safety, began thinking, If Hong Kong is like this before 2047, what will it be like after 2047? It is a question—and a date—that has hung over this city and its demonstrations these past several months. When Britai

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Something Very Strange Seems to Be Synchronizing Distant Galaxies

Massive Structures Galaxies millions of light years away seem to be connected by an unseen network of massive intergalactic structures, which force them to synchronize in ways that can't be explained by existing astrophysics, Vice reports . The discoveries could force us to rethink our fundamental understanding of the universe. "The observed coherence must have some relationship with large-scale

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New findings on nitrous oxide emissions from northern trees surprised scientists

A recent study demonstrates that boreal forests of the Northern Hemisphere are sources of the greenhouse gas nitrous oxide (N2O). The study provides new information on the significance of trees as sinks and sources of greenhouse gases, proving that forests have relevance not only in the absorption of carbon, but also as a source of other greenhouse gases.

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How the Zika virus can spread

The spread of infectious diseases such as Zika depends on many different factors. Researchers were able to generate reliable maps for the transmission risk of the Zika virus in South America.

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Putting a conservation finger on the internet's pulse

Social media is a rich vein of data for researchers to discover important trends in human environmental behavior. But analyzing this staggering quantity of data is a major challenge — until now.

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Antibiotics: New substances break bacterial resistance

Researchers have developed a new, promising class of active ingredients against resistant bacteria. In initial tests in cell cultures and insects, the substances were at least as effective as common antibiotics. The new compounds target a special enzyme that only appears in bacteria in this specific form and that was not previously the target of other antibiotics.

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An exception to the rule: An intact sense of smell without a crucial olfactory brain structure

A handful of left-handed women have excellent senses of smell, despite lacking olfactory bulbs.

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Cholesterol levels in American adults declining since 2013 guideline release

The implementation of the 2013 American College of Cardiology/American Heart Association Guideline on the Treatment of Blood Cholesterol has led to improved overall cholesterol levels for American adults, especially those on cholesterol lowering medications, according to a study published today in the Journal of the American College of Cardiology that examined the impact of the highly anticipated

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Italy to require schools to teach climate change, in world first

Starting September 2020, public schools in Italy will have to incorporate 33 hours of climate-related lessons into their annual curriculum. Italy's education minister said it's part of an effort to place "the environment and society at the core of everything we learn in school." In the U.S., not all states have implemented teaching standards that call for lessons on climate science, but about 80

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When the Biggest Rapper in the World Gets Booed Off Stage

Editorial writers, assemble—there's been another demonstration that civility in America is dead! Drake, the Canadian rapper, actor, singer, and, as of last week, marijuana entrepreneur , took to the stage last night at the Camp Flog Gnaw Carnival, a music festival in Los Angeles. He played a few songs. The crowd grumbled so much that he left. To summarize, the biggest rapper in the world was booe

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Molecular gastronomy gear to impress your friends

Fascinating food. (DepositPhotos /) Molecular gastronomy harnesses the physical and chemical transformations of ingredients to create tasty morsels with totally unexpected textures. Want to impress your friends? Here are our favorite kits and books to get you started. The ultimate introduction kit. (Amazon /) Learn the basics of molecular gastronomy, like how spherification, gelification, and emu

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Non-volatile control of magnetic anisotropy through change of electric polarization

Researchers controlled the magnetic properties of a metal layer through the electrical polarization of a neighboring metal oxide layer. Computational simulations and experimental measurements revealed that the magnetism of a cobalt-platinum alloying layer strongly depended on the polarization direction of an overlying magnesium zinc oxide layer. The concept of magnetic property control using elect

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NASA Unveils Its First Experimental Electric Airplane

The American X-plane series has a long and storied history stretching all the way back to the Bell X-1 that made supersonic flight a reality. NASA, the Air Force, and other parts of the government have used X-planes to explore the flight mechanics of vertical takeoff and landing (VTOL), movable wings, and much more. Now, NASA is working on the first manned X-plane in decades , the all-electric X-

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Viscous water holds the secret to an ice skater's smooth glide

Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03441-3 Ice owes its trademark slipperiness to a layer of melt water with surprising properties.

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A lethal landslide's fury is captured in unprecedented detail

Nature, Published online: 11 November 2019; doi:10.1038/d41586-019-03440-4 Waterlogged ground contributed to the gargantuan debris flow in the Swiss Alps.

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Cops Can Now Get Warrants for Entire DNA Websites

With just a single warrant, a Florida detective obtained access to the DNA profiles of more than a million people — and experts say the case sets a dangerous precedent. Ancestry.com and 23andMe are the largest consumer DNA sites, holding genetic data on 15 million and 10 million people, respectively. However, they aren't the only DNA sites out there — a smaller service, GEDmatch, currently has ab

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Vitamin E Acetate Tied to Vaping Illnesses: CDC

The chemical was found in all 29 lung fluid samples tested.

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Potential vitamin and Alzheimer's drug produced in yeast

Scientists prove that ergothioneine, an important compound that may be used to delay the onset of diseases such as Alzheimer's and dementia, can be produced in baker's yeast.

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Aging in good health: The inequalities are widening

Life expectancy in Switzerland has been growing steadily for decades. But have these additional years been spent in good health or do they only prolong the ills of an aging population? New results show that although the life expectancy of the Swiss population as a whole is growing, people who only attended compulsory schooling are living longer in poor health.

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Quitting Facebook could boost exam results

In research that validates what many parents and educators suspect, students whose grades are below average could boost their exam results if they devoted less time to Facebook and other social networking sites.

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First adult molars are 'living fossils' that hold a 'health record' dating back to the womb

Researchers have found that a person's first permanent molars carry a life-long record of health information dating back to the womb, storing vital information that can connect maternal health to a child's health, even hundreds of years later.

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Non-volatile control of magnetic anisotropy through change of electric polarization

Researchers controlled the magnetic properties of a metal layer through the electrical polarization of a neighboring metal oxide layer. Computational simulations and experimental measurements revealed that the magnetism of a cobalt-platinum alloying layer strongly depended on the polarization direction of an overlying magnesium zinc oxide layer. The concept of magnetic property control using elect

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For older adults, new hepatitis C treatments are safe and effective, study suggests

Thankfully, newer treatments known as interferon-free direct-acting antivirals offer a promising approach to addressing hepatitis C. These medications offer cure rates of more than 90 percent in clinical trials and in real life, but they haven't been studied extensively for older adults.

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New study first to reveal growth rates of deep-sea coral communities

Researchers revealed for the first time growth rates of deep-sea coral communities and the pattern of colonization by various species over time scales of centuries to millennia. Age-dated submarine lava flows helped constrain maximum ages of coral communities.

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Trump Is MAGA-fying the National Medal of Arts

A president can abuse power by pressuring a foreign government to help his campaign. A president also can exploit power by making the cultural world a political prop. This is a story about the latter. Until Donald Trump entered office, not much drama surrounded the prestigious National Medal of Arts. President Ronald Reagan signed legislation creating the award in 1984, and every president since

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Planting a 'Trail of Giants'

Last month, as part of a " Big Little Ideas " series, I mentioned a surprisingly valuable short-term step that communities can take, on their own, for positive climate effects. That is to start planting trees. More on the science behind the idea, plus discussion of exactly how much difference trees can make, from: MIT Technology Review , the long-established Arbor Day Foundation and Nature Conser

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Microsoft Surface Pro X Review: Expensive, Unreliable, Untenable

The slim, light, 2-in-1 computer has a new chip that hobbles the machine's ability to achieve the dreams that Microsoft had for it.

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Apple pulls app that let you stalk people you follow on Instagram

Illustration by Alex Castro / The Verge In October, Instagram phased out the “Following” tab. That’s because it shared a lot of information about what your friends and the people …

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Læge vinder pris for at kvalitetssikre almen praksis

Praktiserende læge Anders Munck modtager årets Halfdan Mahler-pris. Han modtager prisen for sit arbejde inden for kvalitetsudvikling, forskning og uddannelse.

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Photosynthesis seen in a new light by rapid X-ray pulses

Researchers investigated the structure of Photosystem I (PSI) with ultrashort X-ray pulses.

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Genetic diversity facilitates cancer therapy

Cancer patients with more different HLA genes respond better to treatment.

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Drug discount cards could actually cost patients more

New research reveals that brand-name drug discount cards are leading to higher health care spending in Canada — increased costs that are ultimately passed on to patients.

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Mosquito nets: Are they catching more fishes than insects?

Mosquito nets designed to prevent malaria transmission are used for fishing which may devastate tropical coastal ecosystems, according to a new scientific study. The researchers found that most of the fish caught using mosquito nets were smaller than a finger and potentially collect hundreds of individuals.

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Scrambled frog eggs reform into cell-like structures

The cytoplasm of ruptured Xenopus frog eggs spontaneously reorganizes into cell-like compartments, according to a new study. "We were gobsmacked," says lead author James Ferrell, professor of chemical and systems biology and of biochemistry at the Stanford University School of Medicine. "If you blend a computer, you'd end up with tiny bits of computer, and they wouldn't even be able to add two an

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Why NIH is beefing up its data sharing rules after 16 years

Draft update to 2003 policy will require that all grantees make data sets freely available

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What you can do before menopause to ease hot flashes

Maintaining a normal weight and quitting smoking before age 40 may significantly prevent hot flashes and night sweats during menopause, researchers say. Researchers analyzed data from eight studies on more than 21,000 women—aged about 50—from Australia, the UK, the US, and Japan. As reported in the American Journal of Obstetrics and Gynecology , women who were overweight or had obesity and smoked

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Is the end near? Podcaster Dan Carlin discusses his new book.

In his debut work of nonfiction, Dan Carlin discusses the last 6,000 years of apocalyptic moments. The podcaster talks about the choices we're collectively facing in view of the historical record. Carlin warns against judging past deeds on current standards, as we're setting a bad precedent on future generations. None What if you found out that you're alive today only because of the Holocaust? Di

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Gimme shelter: Seven new leech species call freshwater mussels home

The frequent presence of leeches with a hidden lifestyle in the mantle cavity of freshwater mussels has been recorded since the second half of the 19th century. Yet this was, until now, regarded as an accidental phenomenon. Recent research not only reveals seven mussel-associated leech species new to science, but also shows that their association evolved over millions of years.

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A Myth Of Masculinity: The Truth About Testosterone

You really don't know as much about the hormone as you think. (Image credit: Alex Davidson/Getty Images)

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Late talkers twice as likely to have severe, frequent temper tantrums

Toddler speech delays and temper tantrums have long been assumed to be linked. Now, for the first time, a new, large-scale study supports that assumption with data.

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New vaccine protects from widespread, costly infection, mice study shows

A newly developed experimental vaccine was more than eighty percent effective in protecting mice from succumbing to Staphylococcus aureus infection. S. aureus causes more than 30,000 deaths from hospital-acquired infections annually in the US, costing the healthcare system $10 billion.

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Fetal nicotine exposure harms breathing in infants

Exposure to nicotine during development inhibits the function of neurons controlling the tongue, according to research in newborn rats recently published in eNeuro. This impairment may be a factor in sudden infant death syndrome in humans.

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WeWork Reportedly Wants T-Mobile CEO John Legere to Take Over Its Cursed Company

T-Mobile CEO John Legere may be considering hanging up his magenta regalia for good. Read more…

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The tour guide in our brain

Researchers find specific neurons that map memories.

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The puzzle of a proton's proportions

Two new experiments only add to the confusion.

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Nemo's cousins have a special way of finding him

Some clownfish make good use of their UV vision.

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Why the Nile goes where it goes

And why it's been there a long time.

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Cities messing with spring's signals

Urbanisation delays plant growth in warm regions, study finds.

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Deer departed is back again

Scientists and locals ensure a win for conservation.

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