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Team finds fossil iguana nesting burrow in Bahamas
The discovery of the first known fossil iguana nesting burrow clarifies the lizards' prehistoric behavior. The study in PLOS ONE also uncovers new clues to the geologic and natural history of the Bahamas, where the burrow was found. The fossilized burrow dates back to the Late Pleistocene Epoch, about 115,000 years ago, and is located on the island of San Salvador—best known as the likely spot wh
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Access to nature important for mental health during Covid lockdowns
People in European countries with the strictest COVID-19 lockdown policies were more likely to show symptoms of depression and anxiety, according to an international study investigating the impact of disconnecting from nature.
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Go camping in style and comfort with these gifts
Being outdoors is great as long as you're dry, warm, and caffeinated. (Peter Thomas via Unsplashed /) Spending the night outside is fun. But doing it as comfortably and stylishly as possible is even better. For the outdoorsy person who still has their limits, car camping is a great way to get the best of both worlds. Unlike for a backpacking trip, with this type of adventure they can pull the equ
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The best pillow: Sleep better in any position
Sleep soundly with one of these comfortable pillow choices. (Christopher Jolly via Unsplash/) Whether you just bought a new bed, or the pillow you've been using is old, lumpy, and smelly, getting a new pillow is never a bad idea. You should replace your pillow every one to two years to make sure it provides enough support, and prevents your head and neck from sinking too far into the cushion. You
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This Massive New Vertical Farm Can Produce 1,000 Tons of Produce a Year
Going Vertical A new vertical farm , opening on the outskirts of Copenhagen, Denmark, is set to start producing nearly 1,000 metric tons of greens a year. Danish startup Nordic Harvest partnered up with Taiwanese vertical farm tech company YesHealth Group to create the towering facility. The plants are grown on 14 stacked shelves totaling to more than 75,000 square feet , where they rely entirely
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The Scientist?'s LabTalk – Episode 4???
The Past, Present, and Future of Gene Therapy: How to Scale-up Successfully
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Coronavirus News Roundup, December 5-December 11
Pandemic highlights for the week — Read more on ScientificAmerican.com
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What Post-pandemic Repair Could Look Like
The pandemic ravaged America's big cities first, and now its countryside. The public-health and economic repercussions have been felt everywhere. But they have been hardest on the smallest businesses, and the most vulnerable families and communities. This is an update, following a report last month , on plans to repair the damage now being done. 1) What the federal government can do: The Institut
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The First Shots, Grim Milestones, and More Coronavirus News
Catch up on the most important updates from this week.
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Researchers suggest stool transplants can battle serious infections
Could number two be number one when it comes to combating recurrent Clostridium difficile (CDI) infections? Using genetic material analysis and machine learning, researchers have pinpointed several key factors to ensure successful fecal microbiota transplants (FMT), which have proven successful in treating bacterial infections in the gut including illnesses like C. difficile, Crohn's Disease, Coli
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Engaged dads can reduce adolescent behavioral problems, improve well-being
In low-income families, fathers who are engaged in their children's lives can help to improve their mental health and behavior, according to a new study.
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How soil fungi respond to wildfire
When wildfires swept through the North Bay in 2017, a graduate student saw a unique opportunity to study how fire affected his research subject: soil fungi.
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Multiple semiconductor type switching to boost thermoelectric conversion of waste heat
Scientists demonstrate double charge carrier type switching of tin SnSe semiconductor by doping of antimony Sb. The SnSe carrier type switches from p-type to n-type, and re-switches to p-type as doping increases, due to the switching of major Sb substitution site from Se to Sn, promising reliable charge polarity control, leading to realization of SnSe-based p/n homojunction thermoelectric device f
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10 Best LLC Services – Top LLC Formation Services 2021
Looking for the best LLC service on the market? Look no further since we have a list of the best LLC formation services in 2021.
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Snow Leopards Are the Latest Cats to Get the Coronavirus
Lions and tigers had already contracted the virus, but have recovered.
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Hopeful Images From 2020
This has been a year like no other, and moments of joy were difficult to come by. The few happy events that took place did so despite harrowing circumstances—or, in many cases, as a response to overwhelming adversity. Health-care workers took on enormous burdens, saved countless lives, and earned the gratitude and admiration of millions. Celebrations and public events were modified for safety, bu
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Why Some People Are Still on the Fence About the New Vaccine for COVID-19
An epidemiologist explains the psychology behind why millions of Americans — not just "anti-vaxxers" — are hesitant to get shots.
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New insights about age-related macular degeneration could spur better treatments
Experiments in a mouse model have uncovered mechanisms involved in abnormal blood vessel formation in "wet" age-related macular degeneration. Certain inflammatory pathways and proteins may be attractive therapeutic targets for the disease.
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Political partisanship has had outsized influence on individual social mobility during COVID-19 pand
In the United States, political partisanship has played a much stronger role in individuals' decisions to limit their social mobility during the COVID-19 pandemic than the local incidence of the disease in their own
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Vanderbilt researchers discover strong correlation between partisanship and social mobility during COVID-19 pandemic
According to many medical experts, reduced social mobility – defined here as social contact and travel within and among communities – is a necessary factor to contain the spread of COVID-19.
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A saliva-based smartphone platform could rapidly expand COVID-19 testing
Offering an ultrasensitive yet accessible approach to COVID-19 testing, a portable saliva-based smartphone platform provides results within 15 minutes without the resource-intensive laboratory tests the current
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Polarization increases with economic decline, becoming cripplingly contagious
Polarization tends to soar in times of economic duress and rising inequality. Yet, even after financial conditions improve, these divisions may remain deeply rooted, according to a new model debuted in Science Advances.
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A theory as clear as glass
Scientists at The University of Tokyo ran molecular dynamics simulations to compose a more complete theory of the factors that drive crystallization instead of glass formation. They found that tiny changes in material composition can frustrate crystal growth, leading to vitrification. This work may lead to advances in the field of industrial glassmaking.
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Planning ahead protects fish and fisheries
Conservation of fish and other marine life migrating from warming ocean waters will be more effective and also protect commercial fisheries if plans are made now to cope with climate change, according to a Rutgers-led study in the journal Science Advances.
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Military-grade camera shows risks of airborne coronavirus spread
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Astronomers Just Found Cosmic 'Superhighways' For Fast Travel Through The Solar System
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Facial recognition's fate could be decided in 2021
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Battery Law Can Help Europe Become Green Battery Powerhouse
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China's new-generation "artificial sun" commissioned
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Gene editing has made pigs immune to a deadly epidemic
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Water on Mars not as widespread as previously thought, study finds
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Key West Airport Debuts Ultraviolet Disinfection Robot to Fight COVID
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Some HR roles may be taken over by robots in 5 years: Study
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Hyundai takes control of Boston Dynamics in $1.1B deal
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Gene therapy injection in one eye surprises scientists by improving vision in both
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Get Up to $250 in Bitcoin When You Sign Up for a Blockfi Crypto Savings Account
When it comes to investing in crypto , it used to be that your only real option for turning a profit was to buy assets, hold on to them until the price went up, and then sell. Unfortunately, using that strategy successfully required quite a bit of luck. But now there's a smarter way to invest in crypto. Thanks to an innovative crypto startup called BlockFi , today you can actually put your crypto
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A NASA Scientist Heralds "One of the Most Profound Discoveries" of the Space Age
Water Worlds In recent years, scientists have learned that one of Earth's most unique features — its liquid oceans — is far more common throughout the solar system than scientists ever expected. Take Ceres, a dwarf planet orbiting our Sun inside the asteroid belt, which scientists discovered earlier this year is actually an ocean world, according to Discover Magazine . The discovery of abundant w
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Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells
Drosophila Piwi associates with PIWI-interacting RNAs (piRNAs) and represses transposons transcriptionally through heterochromatinization; however, this process is poorly understood. Here, we identify Brahma (Brm), the core adenosine triphosphatase of the SWI/SNF chromatin remodeling complex, as a new Piwi interactor, and show Brm involvement in activating transcription of Piwi-targeted transposo
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Targeted exosome coating gene-chem nanocomplex as "nanoscavenger" for clearing {alpha}-synuclein and immune activation of Parkinsons disease
The most critical problem in the treatment of neurodegenerative diseases is brain neuronal protection, which can be overcome by clearing pathological substances and regulating the immune environment. In the above treatment strategies, the traditional poor drug delivery problem is inevitable. Here, we show an engineering core-shell hybrid system named rabies virus glycoprotein (RVG) peptide–modifi
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Atmospheric circulation over Europe during the Younger Dryas
The Younger Dryas (YD) was a period of rapid climate cooling that occurred at the end of the last glaciation. Here, we present the first palaeoglacier-derived reconstruction of YD precipitation across Europe, determined from 122 reconstructed glaciers and proxy atmospheric temperatures. Positive precipitation anomalies (YD versus modern) are found along much of the western seaboard of Europe and
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Ceramide chain length-dependent protein sorting into selective endoplasmic reticulum exit sites
Protein sorting in the secretory pathway is crucial to maintain cellular compartmentalization and homeostasis. In addition to coat-mediated sorting, the role of lipids in driving protein sorting during secretory transport is a longstanding fundamental question that still remains unanswered. Here, we conduct 3D simultaneous multicolor high-resolution live imaging to demonstrate in vivo that newly
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Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy
Enzyme replacement therapy, in which a functional copy of an enzyme is injected either systemically or directly into the brain of affected individuals, has proven to be an effective strategy for treating certain lysosomal storage diseases. The inefficient uptake of recombinant enzymes via the mannose-6-phosphate receptor, however, prohibits the broad utility of replacement therapy. Here, to impro
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Neurocognitive dynamics of near-threshold voice signal detection and affective voice evaluation
Communication and voice signal detection in noisy environments are universal tasks for many species. The fundamental problem of detecting voice signals in noise (VIN) is underinvestigated especially in its temporal dynamic properties. We investigated VIN as a dynamic signal-to-noise ratio (SNR) problem to determine the neurocognitive dynamics of subthreshold evidence accrual and near-threshold vo
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Ocean planning for species on the move provides substantial benefits and requires few trade-offs
Societies increasingly use multisector ocean planning as a tool to mitigate conflicts over space in the sea, but such plans can be highly sensitive to species redistribution driven by climate change or other factors. A key uncertainty is whether planning ahead for future species redistributions imposes high opportunity costs and sharp trade-offs against current ocean plans. Here, we use more than
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Efficient aortic lymphatic drainage is necessary for atherosclerosis regression induced by ezetimibe
A functional lymphatic vasculature is essential for tissue fluid homeostasis, immunity, and lipid clearance. Although atherosclerosis has been linked to adventitial lymphangiogenesis, the functionality of aortic lymphatic vessels draining the diseased aorta has never been assessed and the role of lymphatic drainage in atherogenesis is not well understood. We develop a method to measure aortic lym
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A mathematical model of ctDNA shedding predicts tumor detection size
Early cancer detection aims to find tumors before they progress to an incurable stage. To determine the potential of circulating tumor DNA (ctDNA) for cancer detection, we developed a mathematical model of tumor evolution and ctDNA shedding to predict the size at which tumors become detectable. From 176 patients with stage I to III lung cancer, we inferred that, on average, 0.014% of a tumor cell
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A biomimetically hierarchical polyetherketoneketone scaffold for osteoporotic bone repair
Osteoporotic fractures are prevalent in society, and their incidence appears to be increasing as the worldwide population ages. However, conventional bone repair materials hardly satisfy the requirements for the repair of pathological fractures. Here, we developed a biomimetic polyetherketoneketone scaffold with a functionalized strontium-doped nanohydroxyapatite coating for osteoporotic bone def
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Topology-dependent asymmetry in systematic errors affects phylogenetic placement of Ctenophora and Xenacoelomorpha
The evolutionary relationships of two animal phyla, Ctenophora and Xenacoelomorpha, have proved highly contentious. Ctenophora have been proposed as the most distant relatives of all other animals (Ctenophora-first rather than the traditional Porifera-first). Xenacoelomorpha may be primitively simple relatives of all other bilaterally symmetrical animals (Nephrozoa) or simplified relatives of ech
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Structures and an activation mechanism of human potassium-chloride cotransporters
Potassium-chloride cotransporters KCC1 to KCC4 mediate the coupled export of potassium and chloride across the plasma membrane and play important roles in cell volume regulation, auditory system function, and -aminobutyric acid (GABA) and glycine-mediated inhibitory neurotransmission. Here, we present 2.9- to 3.6-Å resolution structures of full-length human KCC2, KCC3, and KCC4. All three KCCs ad
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A fully biodegradable and self-electrified device for neuroregenerative medicine
Peripheral nerve regeneration remains one of the greatest challenges in regenerative medicine. Deprivation of sensory and/or motor functions often occurs with severe injuries even treated by the most advanced microsurgical intervention. Although electrical stimulation represents an essential nonpharmacological therapy that proved to be beneficial for nerve regeneration, the postoperative delivery
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Functional innovations of PIN auxin transporters mark crucial evolutionary transitions during rise of flowering plants
Flowering plants display the highest diversity among plant species and have notably shaped terrestrial landscapes. Nonetheless, the evolutionary origin of their unprecedented morphological complexity remains largely an enigma. Here, we show that the coevolution of cis-regulatory and coding regions of PIN-FORMED ( PIN ) auxin transporters confined their expression to certain cell types and directe
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Size-transformable antigen-presenting cell-mimicking nanovesicles potentiate effective cancer immunotherapy
Artificial antigen-presenting cells (aAPCs) can stimulate CD8 + T cell activation. While nanosized aAPCs (naAPCs) have a better safety profile than microsized (maAPCs), they generally induce a weaker T cell response. Treatment with aAPCs alone is insufficient due to the lack of autologous antigen-specific CD8 + T cells. Here, we devised a nanovaccine for antigen-specific CD8 + T cell preactivatio
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Physical origin of glass formation from multicomponent systems
The origin of glass formation is one of the most fundamental issues in glass science. The glass-forming ability (GFA) of multicomponent systems, such as metallic glasses and phase-change materials, can be enormously changed by slight modifications of the constituted elements and compositions. However, its physical origin remains mostly unknown. Here, by molecular dynamics simulations, we study th
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Polarization under rising inequality and economic decline
Social and political polarization is an important source of conflict in many societies. Understanding its causes has become a priority of scholars across disciplines. We demonstrate that shifts in socialization strategies analogous to political polarization can arise as a locally beneficial response to both rising wealth inequality and economic decline. In many contexts, interaction with diverse
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Calmodulin acts as a state-dependent switch to control a cardiac potassium channel opening
Calmodulin (CaM) and phosphatidylinositol 4,5-bisphosphate (PIP 2 ) are potent regulators of the voltage-gated potassium channel KCNQ1 (K V 7.1), which conducts the cardiac I Ks current. Although cryo–electron microscopy structures revealed intricate interactions between the KCNQ1 voltage-sensing domain (VSD), CaM, and PIP 2 , the functional consequences of these interactions remain unknown. Here
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Quality of CD8+ T cell immunity evoked in lymph nodes is compartmentalized by route of antigen transport and functional in tumor context
Revealing the mechanisms that underlie the expansion of antitumor CD8 + T cells that are associated with improved clinical outcomes is critical to improving immunotherapeutic management of melanoma. How the lymphatic system, which orchestrates the complex sensing of antigen by lymphocytes to mount an adaptive immune response, facilitates this response in the context of malignancy is incompletely
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Rapid and ongoing evolution of repetitive sequence structures in human centromeres
Our understanding of centromere sequence variation across human populations is limited by its extremely long nested repeat structures called higher-order repeats that are challenging to sequence. Here, we analyzed chromosomes 11, 17, and X using long-read sequencing data for 36 individuals from diverse populations including a Han Chinese trio and 21 Japanese. We revealed substantial structural di
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Skin-interfaced microfluidic system with personalized sweating rate and sweat chloride analytics for sports science applications
Advanced capabilities in noninvasive, in situ monitoring of sweating rate and sweat electrolyte losses could enable real-time personalized fluid-electrolyte intake recommendations. Established sweat analysis techniques using absorbent patches require post-collection harvesting and benchtop analysis of sweat and are thus impractical for ambulatory use. Here, we introduce a skin-interfaced wearable
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Multicultural cooking classes offer up something tasty on Zoom
tahdig rice League of Kitchens instructor Mab Abbasgholizadeh teaches her students how to make classic Persian dishes, including crispy tahdig rice . (Courtesy League of Kitchens /) This story originally featured on Saveur . Sunday afternoon on the internet, League of Kitchens instructor extraordinaire Mab Abbasgholizadeh was teaching us how to make baghali ghatogh —a Persian dish of beans, eggs,
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Daily briefing: Australian COVID vaccine trial abandoned after HIV 'false positives'
Nature, Published online: 11 December 2020; doi:10.1038/d41586-020-03570-0 HIV protein fragment posed no risk to human health, but could interfere with HIV screening tests. Plus, China launches twin-satellite mission and a COVID vaccine is poised for authorization in the US.
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Effective planning ahead protects fish and fisheries
Conservation of fish and other marine life migrating from warming ocean waters will be more effective and also protect commercial fisheries if plans are made now to cope with climate change, according to a Rutgers-led study in the journal Science Advances.
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Polarization increases with economic decline, becoming cripplingly contagious
The rise of populist movements is changing political systems around the world. As support for these "anti-elite" movements intensifies, many are scrambling to understand whether economic decline and intensifying inter-group conflict are playing a role.
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A theory as clear as glass
Researchers from the Institute of Industrial Science at the University of Tokyo used molecular dynamics calculations to simulate the glass-forming ability of metallic mixtures. They show that even small changes in composition can strongly influence the likelihood that a material will assume a crystalline versus a glassy state upon cooling. This work may lead to a universal theory of glass formatio
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Pandemic-Driven Drop in CO2 Emissions Imperceptible in Atmosphere
Sustained reductions are needed to halt the buildup of heat-trapping greenhouse gases — Read more on ScientificAmerican.com
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Effective planning ahead protects fish and fisheries
Conservation of fish and other marine life migrating from warming ocean waters will be more effective and also protect commercial fisheries if plans are made now to cope with climate change, according to a Rutgers-led study in the journal Science Advances.
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Gene Therapy in One Eye Improves Vision in Both Eyes
It's not clear why the patients with Leber hereditary optic neuropathy, a mitochondrial disorder that causes blindness, also experienced the modest benefits in their untreated eye.
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