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Antarctica appears to have broken a heat record
The temperature in northern Antarctica hit nearly 65 degrees (18.3 degrees Celsius), a likely heat record on the continent best known for snow, ice and penguins.
13h
45<>corona
Mapping the coronavirus outbreak
The FT will be tracking the coronavirus outbreak as it spreads
13h
<>corona
For en måned siden kendte de ikke Corona-sekvenserne – I dag kan dansk beredskab tjekke patienter på seks timer
PLUS. På blot to måneder har corona-virussen 2019-nCoV haft held med at nå rundt til langt over 20.000 mennesker, primært i Kina. Sideløbende har det danske beredskab arbejdet bag kulisserne på først og fremmest at kunne stille en tidlig diagnose.
15h
45
'Size 0' eller runde hofter? Test, om du kender kropsidealerne gennem tiden
Tynd, trænet eller fyldig? Idealer skifter og varer sjældent mere end et årti.
15h
1K
Lyme disease cases may rise 92 per cent in US due to climate change
Climate change could nearly double new cases of Lyme disease by the end of the century in the US, even if the world manages to limit warming to levels agreed under the Paris climate deal
15h
100+
The Divides That Make Hong Kong and West Berlin
Hong Kong and West Berlin stand about as far apart as two cities can be. Yet for most of the second half of the 20th century, they were doppelgängers in an important way: Each was a focal point of Cold War tensions, linked by the shared stresses of being a battleground for two diametrically opposed ideologies. During the final dozen years of the last century, the unwinding of the Cold War changed
17h
14K<>corona
Coronavirus Live Updates: An American in Wuhan Dies of the Virus
The death appeared to be the first of a U.S. citizen from the disease and prompted further questions about Beijing's handling of the outbreak.
18h
Locusts: global swarming
Many African farmers face ruin as a result of this year's infestations
18h
1K<>corona
China's ghost cities: fear of coronavirus leaves streets deserted
Residents say they are trapped in their own homes as the country grapples with the expanding outbreak Construction workers are putting together the final touches on the Changying coronavirus isolation ward in Beijing, drilling holes in a brick wall for a heavy gate and setting up CCTV cameras trained on each of the units – small rectangular rooms with a bathroom and a window. It took a week to bu
18h
79<>2<>albatrosser
Albatrosser avslöjar tjuvfiskare
Albatrossen kan glidflyga långa sträckor utan ansträngning. Genom att sätta GPS-sändare på dem har en grupp franska forskare använt sig av dem för att avslöja tjuvfiskare.
18h
23<>2<>robot
Robotar som svettas ska klara värmen
Alltfler robotar utformas så att de liknar människor, och det människoliknande i robotars konstruktion har nu tagit ytterligare ett steg: svettfunktionen har kopierats.
18h
2K
Everybody vs. Pete
Tonight was Pete Buttigieg's turn to experience the unique treatment a front-runner receives during a presidential-primary debate. Buttigieg's Democratic rivals greeted the co-winner of the Iowa caucuses with a pile-on as the race shifted to New Hampshire. Multiple candidates onstage belittled his relative lack of governing experience as the former mayor of South Bend, Indiana. "We have a newcome
20h
500+
Why is there less snow on Scotland's mountains this year?
Enthusiasts say they have noticed a difference in conditions on the hills in recent years.
21h
400+
The research centre dedicated to the science of cracks
Strathclyde University is claiming a world-first with a research centre that simulates and analyses fissures.
21h
43
Neandertals Tooled Around with Clams
Neandertals ate clams and then modified the hard shells into tools for cutting and scraping.
21h
High-resolution structural insights into the heliorhodopsin family [Biophysics and Computational Biology]
Rhodopsins are the most abundant light-harvesting proteins. A new family of rhodopsins, heliorhodopsins (HeRs), has recently been discovered. Unlike in the known rhodopsins, in HeRs the N termini face the cytoplasm. The function of HeRs remains unknown. We present the structures of the bacterial HeR-48C12 in two states at the…
21h
In situ genetic engineering of tumors for long-lasting and systemic immunotherapy [Engineering]
Cancer immunotherapy has been the subject of extensive research, but highly effective and broadly applicable methods remain elusive. Moreover, a general approach to engender endogenous patient-specific cellular therapy, without the need for a priori knowledge of tumor antigen, ex vivo cellular manipulation, or cellular manufacture, could dramatically reduce costs and…
21h
Global gene flow releases invasive plants from environmental constraints on genetic diversity [Ecology]
When plants establish outside their native range, their ability to adapt to the new environment is influenced by both demography and dispersal. However, the relative importance of these two factors is poorly understood. To quantify the influence of demography and dispersal on patterns of genetic diversity underlying adaptation, we used…
21h
Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling [Biochemistry]
The COP9 signalosome (CSN) is an evolutionarily conserved eight-subunit (CSN1–8) protein complex that controls protein ubiquitination by deneddylating Cullin-RING E3 ligases (CRLs). The activation and function of CSN hinges on its structural dynamics, which has been challenging to decipher by conventional tools. Here, we have developed a multichemistry cross-linking mass…
21h
Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism [Medical Sciences]
The binding of lipoprotein lipase (LPL) to GPIHBP1 focuses the intravascular hydrolysis of triglyceride-rich lipoproteins on the surface of capillary endothelial cells. This process provides essential lipid nutrients for vital tissues (e.g., heart, skeletal muscle, and adipose tissue). Deficiencies in either LPL or GPIHBP1 impair triglyceride hydrolysis, resulting in severe…
21h
Connect-seq to superimpose molecular on anatomical neural circuit maps [Neuroscience]
The mouse brain contains about 75 million neurons interconnected in a vast array of neural circuits. The identities and functions of individual neuronal components of most circuits are undefined. Here we describe a method, termed "Connect-seq," which combines retrograde viral tracing and single-cell transcriptomics to uncover the molecular identities of…
21h
PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection [Immunology and Inflammation]
The migratory patterns of virus-specific CD8 T cells during chronic viral infection are not well understood. To address this issue, we have done parabiosis experiments during chronic lymphocytic choriomeningitis virus (LCMV) infection of mice. We found that despite the high frequency of virus-specific CD8 T cells in both lymphoid and…
21h
The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition [Cell Biology]
Endothelial cells play an important role in maintenance of the vascular system and the repair after injury. Under proinflammatory conditions, endothelial cells can acquire a mesenchymal phenotype by a process named endothelial-to-mesenchymal transition (EndMT), which affects the functional properties of endothelial cells. Here, we investigated the epigenetic control of EndMT….
21h
Understanding the genetic architecture of human retinal degenerations [Commentaries]
Overview of Inherited Retinal Degenerations Inherited retinal degenerations are a clinically and genetically heterogeneous group of blinding diseases characterized by progressive degeneration of the neuroretina and/or the retinal pigment epithelium. Currently, over 300 genes have been implicated in retinal degenerations (RetNet: https://sph.uth.edu/RetNet/). While mutations, or causative variants,
21h
51
The role of worldviews in the governance of sustainable mobility [Sustainability Science]
Sustainable development aims for a viable interaction between human and physical nature. However, how do we perceive the social and natural world, rationalize our behavior, and modify our ways of life? Here, we apply the idea of worldviews to cognition and rationality in transport since a transition to sustainable mobility…
21h
62
Neandertals Tooled Around with Clams
Neandertals ate clams and then modified the hard shells into tools for cutting and scraping. — Read more on ScientificAmerican.com
22h
25<><>fakenews<>climate
22h
Future of transportation in 80 years?
What can we expect from transportation in 80 years? How will we get around and how would you like to see it? submitted by /u/russiansallday [link] [comments]
22h
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