A team at the National Institute of Standards and Technology (NIST) has developed a tool to monitor changes in widely used composite materials known as fiber reinforced polymers (FRPs), which can be found in everything from aerospace and infrastructure to wind turbines. The new tool, integrated into these materials, can help measure the damage that occurs as they age.
Flies belonging to the genus Drosophila combat oxidative stress by removing excess fat from their blood. This remarkable mechanism proves that evolution has no shortage of answers to a problem that affects all life on Earth.
The first detailed cell atlas of the immune cells and gut bacteria within the human colon has been created. The study from the Wellcome Sanger Institute and collaborators revealed different immune niches, showing changes in the bacterial microbiome and immune cells throughout the colon.
By making specially designed slits in Plexiglas, Danish researchers have made it stronger, lighter and more flexible. The new knowledge could be used to make microchips, for example, much more durable.
Thin Air A team of scientists at the University of Massachusetts Amherst have come up with a clever device they dubbed the "air-gen ," which can generate electricity from moisture found in air. According to the team, their discovery could revolutionize green energy by offering some key advantages over other renewable source including sun or wind energy. "We are literally making electricity out of
Ju mer socker vi äter, desto färre vitaminer och mineraler får vi i oss, visar ny forskning från Lunds universitets Diabetescentrum. Men forskarna anser inte att deras studie ensam räcker som underlag för ändra dagens kostrekommendationer om hur mycket tillsatt socker vi bör äta.
Eating a Mediterranean diet for a year boosts the types of gut bacteria linked to 'healthy' ageing, while reducing those associated with harmful inflammation in older people, indicates a five-country study, published online in the journal Gut.
Voight- Kampff German scientists say that for the first time ever, they've created a lab-grown artificial genome that can reproduce itself like a natural one. It's not quite one of those replicants from "Blade Runner," but it's a step toward the holy grail of synthetic biology: fully artificial organisms that can survive and reproduce like the real thing. The Blueprint In a paper published in the
Danish and Norwegian researchers have moved one step closer to understanding where face blindness stems from in the brain. The condition affects approx. 2% of the population. Although we mainly use the right side of the brain to process visual impressions of faces, the research team has now discovered that an area in the back of the left side of the brain responds differently in people with face b
Do you have anxiety? Have you tried just about everything to get over it, but it just keeps coming back? Perhaps you thought you had got over it, only for the symptoms to return with a vengeance? Whatever your circumstances, science can help you to beat anxiety for good. Anxiety can present as fear, restlessness, an inability to focus at work or school, finding it hard to fall or stay asleep at n
One of the ocean's loudest creatures is smaller than you'd expect — and will get even louder and more troublesome to humans and sea life as the ocean warms, according to new research presented at the Ocean Sciences Meeting 2020.
Scientists at Tokyo Institute of Technology (Tokyo Tech) demonstrate the first visible-light photoelectrochemical system for water splitting using TiO2 enhanced with an earth-abundant material—cobalt. The proposed approach is simple and represents a stepping stone in the quest to achieve affordable water splitting to produce hydrogen, a clean alternative to fossil fuel.
Researchers say whether a family has lots of boys or girls, or equal mix, is down to chance Mrs Bennet may have lamented having five daughters and no son in Pride and Prejudice, but it appears that Lizzy and her sisters would be unlikely to produce a similar set of children: research suggests having multiple offspring of the same sex does not run in the family. In the largest study of its kind, r
While fear memory — or the ability to remember contexts in which to be afraid — is important for survival, too much of it, and an inability to forget contexts that no longer apply, hinders daily activities. Recently, scientists from Japan found that a certain opioid drug can help mask some fear memory without causing undesirable side effects. This could make new therapies possible for anxiety di
The precipitous drop in HPV vaccination rates after suspension of proactive recommendations by the government in 2013 could result in an additional 25,000 cervical cancer cases and more than 5,000 additional deaths among females born between 1994 to 2007 in Japan. However, swift action by the government could mitigate much of this damage according to a study in Lancet Public Health.
People who rely on social media for information may be more likely to be misinformed about vaccines than those who rely on traditional media, according to a new study. The study, which researchers based on nationally representative surveys of nearly 2,500 US adults, found that up to 20% of respondents were at least somewhat misinformed about vaccines. Such a high level of misinformation is "worry
Going Viral Right between the conspiracy theorists advocating for drinking bleach and your aunt on the airplane with the essential oils, vaccine misinformation has, in fact, found a home online. A recent survey found 20% of Americans are likely to be misinformed about vaccinations—and that they were more likely to have found their misinformation online than not. Contagious In 2019, the United Sta
Democratic primary voters care deeply about electability. What most want is simple: a candidate who can beat President Donald Trump in November. So they worry about whether former Vice President Joe Biden will inspire young people, and about whether Senator Bernie Sanders will scare away old people. They debate whether a political revolution is necessary to energize the base, or whether the revol
People who rely on social media for information were more likely to be misinformed about vaccines than those who rely on traditional media, according to a new study. The study, based on surveys of nearly 2,500 US adults, found that up to 20% of respondents were at least somewhat misinformed about vaccines.
Early exposure of babies to household cleaning products is associated with the development of childhood asthma and wheeze by age 3 years, according to new research in CMAJ (Canadian Medical Association Journal).
The study was published today in the Canadian Medical Association Journal. It found that young infants (birth to three months) living in homes where household cleaning products were used frequently were more likely to develop childhood wheeze and asthma by three years of age.
The Swedish team responsible for uterine transplantation research has, for the first time, transplanted a uterus from a deceased donor. The operation proceeded without complications and the recipient is doing well.
Malariamyggor har receptorer på sina antenner och mundelar som känner av koldioxid och kroppslukt. Med dessa sinnen kan en blodtörstande mygghona upptäcka en människa på ganska långt håll. På nära håll är det i stället offrets kroppsvärme som hon orienterar sig efter, men hur detta går till i detalj har varit okänt fram till nu.
Forskare har hittat ett sätt att använda maskininlärning för att diagnostisera patienter med förhöjda kolesterolnivåer. Algoritmen som tränats med patientdata kan uppskatta sannolikheten för om en patient lider av Familial hypercholesterolemia, en vanlig genetisk sjukdom, eller inte. Familial hypercholesterolemia (FH) är en vanlig genetisk sjukdom som drabbar en av 250 personer. Sjukdomen påverka
The authors of a 2019 Nature paper on hydrology have retracted it after commenters pointed out a slew of errors with the work. The article, "Global analysis of streamflow response to forest management," was written by Jaivime Evaristo, of the Copernicus Institute of Sustainable Development at Utrecht University, in The Netherlands, and Jeffrey McDonnell, of … Continue reading
Three in four Australians—almost 18 million people—were affected by the country's deadly bushfire crisis, according to a survey released Tuesday that also pointed to plummeting support for the government and for coal projects.
To maintain plant and animal species on earth, we need not only to consider the direct effects of climate change, but we must also take other equally important environmental issues into consideration – such as changes in agricultural and forestry practices and indirect effects of climate such as increased frequencies of fires.
Dagens energisystem klarar inte framtidens extremväder. En ökande andel förnybart ökar sårbarheten ytterligare. Men vi slipper bli strömlösa om vi planerar redan nu, menar forskare som räknat på 13 framtida klimatscenarier i 30 svenska städer. Klimatet förändras och vi får räkna med ett allt lynnigare klimat framöver i form av exempelvis fler stormar, fler stekheta, vindstilla sommardagar liksom
A 784,000 year climate simulation suggests that Southern Ocean sea ice significantly reduces deep ocean ventilation to the atmosphere during glacial periods by reducing both atmospheric exposure of surface waters and vertical mixing of deep ocean waters; in a global carbon cycle model, these effects led to a 40 ppm reduction in atmospheric CO2 during glacial periods relative to pre-industrial leve
Physical climate risk from extreme weather events remains unaccounted for in financial markets, a new paper warns. Without better knowledge of the risk, the average energy investor can only hope that the next extreme event won't trigger a sudden correction, according to the research. "If the market doesn't do a better job of accounting for climate, we could have a recession—the likes of which we'
Global schemes to fight climate change may miss their mark by ignoring the "fundamental connections" in how food is produced, supplied and consumed, say scientists in a new paper published in the journal Nature Food.
Jordens ekosystem absorberar nästan en tredjedel av de växthusgaser som släpps ut av människan. Med fri tillgång till näringsämnen skulle växterna binda ännu mer koldioxid. Forskare undersöker nu vad som begränsar växternas tillgång på kväve- och fosfor globalt. Växter behöver vatten, solljus och koldioxid för att växa. Men också näringsämnen som kväve och fosfor. Ju mer begränsade växter är av k
A two degree Centigrade increase in global average temperature will lead to catastrophic consequences for the planet. Humanity has a maximum of 20 to 30 years to prevent this. Georgy Safonov, Director of the HSE Centre for Environmental and Natural Resource Economics, studied the impact of warming on countries in Central and Eastern Europe, Caucasus and Central Asia. http://library.fes.de/pdf-file
Scientists propose best use of funds pledged by Amazon founder to fight climate crisis Amazon revenue to restore the Amazon rainforest? A political war chest in the US to counter the pernicious influence of big oil? Or research funding for "moonshot" technologies to suck carbon dioxide out of the atmosphere? The world's richest man is never going to be short of suggestions for how to spend money,
Warning Signs If climate change goes unchecked and extreme weather events continue to devastate communities, the global economy could be taken down as collateral damage. Investors and business leaders have been slow to adapt their investments to the risks posed by ongoing climate change and the destructive weather it causes, according to research published Monday in the journal Nature Energy — wh
No single country is adequately protecting children's health, their environment and their futures, finds a landmark report released today by a Commission of over 40 child and adolescent health experts from around the world. The Commission was convened by the World Health Organization (WHO), UNICEF and The Lancet.
A new model could boost investment in anaerobic digesters, farm-based sustainable energy projects that generate electricity from manure. The model uses advanced computational techniques to address uncertainty, which would allow investors to more accurately predict whether a project will turn a profit. "Converting animal waste into electricity can be profitable for farmers while also producing env
Conversion of energy is a constant process but measuring the efficiency of this conversion is not an easy task. Quantifying the heat emission of the object that absorbs energy has been proven to be a good indicator. Scientists have now devised a technique that can perform this measurement easily and accurately, and this novel technology can shed light on the energy transfer processes in systems ra
David and Sally Abel announce positive test, as UK says it is trying to organise evacuation of British passengers Coronavirus outbreak – live updates A British couple who published video diaries from a cruise ship quarantined off the coast of Japan say they have tested positive for the coronavirus, as the UK government announced plans to evacuate citizens from the ship. David Abel wrote in a Face
Four members of same family die during self-quarantine at centre of outbreak in Wuhan A Chinese film director, his sister, mother and father have all died from the coronavirus, the latest high-profile victims of the disease in Wuhan, the city at the centre of the outbreak. Chang Kai, 55, died on 14 February. His parents died over the previous two weeks, after the family spent days together in sel
Students and a restaurant worker in Southampton report racist incidents, prompting fears in the community Coronavirus outbreak – live updates A spate of racist incidents linked to the coronavirus outbreak are being investigated by police, prompting fears among members of the Chinese community that they will face abuse if they wear face masks. Chinese students in Southampton have been targeted wit
Covid-19 not as deadly as Sars, figures show, and children not affected in same way as adults Coronavirus – latest updates Covid-19, the new coronavirus that has killed nearly 1,800 people in China, causes only mild disease in four out of five people who get it, the World Health Organization has said. "It appears that Covid-19 is not as deadly as other coronaviruses, including Sars and Mers," sai
UK trying to track passengers who disembarked from MV Westerdam and Apple warns of iPhone shortages as economic impact deepens. Follow the latest news and updates here Apple warns of iPhone shortages amid factory shutdown UK trying to contact passengers who left MV Westerdam Virus causes mild disease in four out of five patients, says WHO What is coronavirus and what should I do if I have symptom
Deaths in China from the virus have risen above 2,000 after a 40% spike in fatalities in Hubei province – but new cases in the province are down. Follow all the latest news here China's handling of the virus is a diplomatic challenge for the WHO Chinese people in UK targeted with abuse over outbreak 12.43am GMT Stock markets in Asia are in positive territory today after a dip yesterday caused lar
The director of a hospital in Wuhan, the Chinese city where the coronavirus COVID-19 outbreak began, has died after contracting the disease. Chinese state media confirmed the death of neurosurgeon Liu Zhiming, who was the director of Wuhan Wuchang Hospital. That makes him the latest of at least six health workers killed by the pneumonia-like virus, Time reports . In the Chinese cities hit hardest
The ongoing outbreak of COVID-19 (formerly called the 2019 novel coronavirus) in China and some neighboring countries has led to unprecedented efforts to isolate, control, and halt the spread of the virus that has now infected more than 73,400 people, and caused at least 1,875 deaths since December of 2019. Across much of China, travel is restricted and residents remain in their homes, and the ec
In city of 11m, officials threaten with punishment those who delay reporting symptoms Coronavirus outbreak – live updates One of Wuhan's most senior doctors has died after contracting the coronavirus as authorities began a sweeping campaign inside the city to seek out patients infected with the virus. Liu Zhiming had taken part in the battle against the virus from the start and had made important
The 2019 novel coronavirus (CoV) causes fatal pneumonia that has claimed over 1300 lives, with more than 52000 confirmed cases of infection by February 13, 2020, all in the span of just over a month. But, what is this virus? Is it a new virus altogether? Where did it come from? Scientists from top research institutes in China teamed up to answer these questions, and this pioneering study has been
It's Tuesday, February 18. In today's newsletter: Why the coronavirus outbreak could bring out the worst in Trump. Plus: Is Bernie Sanders as polarizing as elite Democrats claim he is? * « TODAY IN POLITICS » (HAPPY TOGETHER / SHUTTERSTOCK / ARSH RAZIUDDIN / THE ATLANTIC ) The Trump administration isn't ready for the coronavirus. The outbreak of COVID-19, as the illness is now called, has thrown
When a senior White House aide would brief President Donald Trump in 2018 about an Ebola-virus outbreak in central Africa, it was plainly evident that hardships roiling a far-flung part of the world didn't command his attention. He was zoning out. "It was like talking to a wall," a person familiar with the matter told me. Now a new coronavirus that originated in China is confronting him with a po
There is no way to completely stop a pandemic from coming, says former United Nations medical officer and a key player in the World Health Organization's (WHO) smallpox eradication program in South Asia, Larry Brilliant. Being prepared and having a good public health infrastructure are necessary to reduce impact. Pandemics like ebola are more likely to start at the edges of poor countries, away f
Just keep soaping. (DepositPhotos/) Whether you're anxious about the outbreak of the novel coronavirus COVID-19 or simply fretting over the usual spread of seasonal influenza, there is a simple and easy way to reduce your risk of catching communicable diseases: washing your hands. The Centers for Disease Control and Prevention calls hand washing "one of the most important steps we can take to avo
Mosquito-borne helminth infections are responsible for a significant worldwide disease burden in both humans and animals. Accordingly, development of novel strategies to reduce disease transmission by targeting these pathogens in the vector are of paramount importance. We found that a strain of Aedes aegypti that is refractory to infection by…
Plants and fungi are closely associated through parasitic or symbiotic relationships in which bidirectional exchanges of cellular contents occur. Recently, a plant virus was shown to be transmitted from a plant to a fungus, but it is unknown whether fungal viruses can also cross host barriers and spread to plants….
An anonymous group of digital privacy activists calling itself the Earnest Project claims that it gathered DNA samples from a long list of world leaders — and plans to auction it off. The group says it got the genetic samples by collecting scooped up things like loose hairs, used utensils and wine glasses, and other objects from the 2018 World Economic Forum in Davos, Switzerland, according to On
Millipedes are usually too shy to mate above ground, but this species has no issue getting it on in a petri dish. (Stephanie Ware, Field Museum/) After much anticipation, we now know exactly how millipedes have sex. With the help of imaging techniques that take advantage of glowing millipede tissues, researchers have illuminated this arthropod's intricate mating process. This finding marks the co
Weeping is informed by everything from culture and identity to social standing – and studying it could help us better understand ourselves It is common for people to scoff at tears as a behaviour and a subject of investigation. Tears are, they say, feminine, self-indulgent and melodramatic. It is not hard to notice, in those beliefs, the patriarchal assumptions about what should be valued and wha
A healthy diet is essential to living well, but should we change what we eat as we age? Researchers have found strong evidence of the link between food groups and memory loss and its comorbidities. Her findings point to a need for age-specific dietary guidelines as the links may vary with age — people aged 80+ with a low consumption of cereals are at highest risk of memory loss and comorbid heart
A new study by the Human Memory and Cognition Laboratory at the University of Illinois at Urbana-Champaign, led by psychology professor Aaron Benjamin, has found that learning by testing yourself improves your ability to make inferences about the subject matter as compared to rote restudy. The study "Long-term Inference and Memory Following Retrieval Practice" was published in Memory & Cognition.
What are the symptoms of the virus from Wuhan in China, how does it spread, how many people have died and when should you call a doctor? Find all our coronavirus coverage here How to protect yourself from infection It is caused by a member of the coronavirus family that has never been encountered before. Like other coronaviruses, it has come from animals. Many of those initially infected either w
Australia's first people ate a wide variety of fruits, vegetables, nuts and other plant foods, many of which would have taken considerable time and knowledge to prepare, according to our analysis of charred plant remains from a site dating back to 65,000 years ago.
Many thinkers have been killed for their ideas. Some got away with exile. Most of the ones we'll look at here were driven out by the government, but others fled for their own safety. The fact that some of these thinkers are still famous centuries after their exile suggests they might have been on to something, even if their countrymen disagreed. It's no secret that people often have a difficult t
Reading, studies show, increases empathy and charitable thinking . Fiction has even been credited with helping readers improve their understanding of others and make changes in their own lives. The UN has identified 17 interconnected goals for a sustainable future, from tackling poverty to climate action. The aim is to achieve all of these goals by 2030. Unesco's Cities of Literature have picked
Leading educators and clinical experts on transgender health care from Harvard, Fenway Health, and The Fenway Institute address access issues for transgender patients seeking care by providing a plan to integrate gender-affirming hormone therapy, surgical referrals, or wrap-around services into primary care.
In this hilarious, whirlwind tour of the last four billion years of evolution, paleontologist and TED Fellow Lauren Sallan introduces us to some of the wildly diverse animals that roamed the prehistoric planet (from sharks with wings to galloping crocodiles and long-necked rhinos) and shows why paleontology is about way more than dinosaurs.
Scientific Reports, Published online: 18 February 2020; doi:10.1038/s41598-020-59846-y A comparative study on the mechanical, physical and morphological properties of cement-micro/nanoFe 3 O 4 composite
Since 1997, Todd Hochberg has been going to hospitals to photograph families after the death of a baby. These requests come at all times of day and night—more often at night, it seems, when it is a stillbirth. If he can, Hochberg will be there for the birth itself, and then in the emotional hours after as parents see and hold and even bathe their dead child while saying goodbye. For parents, thes
Marine sediments cover more than two thirds of our planet's surface. Nevertheless, they are scarcely explored, especially in the deeper regions of the oceans. For their nutrition, the bacteria in the deep ocean are almost entirely dependent on remnants of organisms that trickle down from the upper water layers. Depending on how they process this material, it either remains in the depths of the oce
We show that platinum displays a self-adjusting surface that is active for the hydrogenation of acetone over a wide range of reaction conditions. Reaction kinetics measurements under steady-state and transient conditions at temperatures near 350 K, electronic structure calculations employing density-functional theory, and microkinetic modeling were employed to study this…
A chemist from RUDN University as a part of a team of researchers has synthesized new highly active catalysts for the production of ultra-high molecular weight polyethylene, which is necessary in the production of bulletproof vests, pipes, parachutes, prostheses and much more. The use of the new catalysts will significantly reduce the production cost of this type of polyethylene. The article was p
Artificial intelligence can help doctors and patients with meningiomas make better treatment decisions, according to a new study. Meningiomas are tumors that arise from the membranes surrounding the brain and spinal cord. They are the most common primary central nervous system tumor, with an incidence of 8.14 per 100,000 population. While they generally have better outcomes than other brain tumor
Untethered synthetic microrobots have significant potential to revolutionize minimally invasive medical interventions in the future. However, their relatively slow speed and low controllability near surfaces typically are some of the barriers standing in the way of their medical applications. Here, we introduce acoustically powered microrobots with a fast, unidirectional surface-slipping…
Keep visitors' allergies at bay. (Depositphotos/) Pet owners are used to existing inside a mini-dust cloud of fur and dander that follows them around like they're Pig-Pen from the Peanuts cartoons. It's on your clothes, it covers every piece of furniture you own, and it's in the air you breathe. Lint rollers and vacuum cleaners can help with the first two, but for the last one, you need an air pu
Susan Schneider, associate professor of philosophy and cognitive science and director of the AI, Mind and Society (AIMS) Group at UConn, has gained a national and international reputation for her writing on the philosophical implications of artificial intelligence (AI). She writes about the nature of the self and mind, AI, cognitive science, and astrobiology in publications including the New York
Optical microscopy for biomedical samples requires expertise in staining to visualize structure and composition. Midinfrared (mid-IR) spectroscopic imaging offers label-free molecular recording and virtual staining by probing fundamental vibrational modes of molecular components. This quantitative signal can be combined with machine learning to enable microscopy in diverse fields from cancer…
New research finds tropical forest disturbance goes beyond species loss and includes a shift towards smaller seeds and an increase in the proportion of trees dispersed by animals, impacting how the ecosystem functions.
In many industrial and environmental applications, determining the size and distribution of microscopic particles is essential. For example, in the pharmaceutical industry, inline measurement and control of particles containing various chemical ingredients (before consolidation in tablets) may critically enhance the yield and quality of the final medical product. Also, the air we breathe, water we
Developing B cells can be positively or negatively selected by self-antigens, but the mechanisms that determine these outcomes are incompletely understood. Here, we show that a B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to let-7 gene expression. Ectopic expression…
Peptide self-assembly, wherein molecule A associates with other A molecules to form fibrillar β-sheet structures, is common in nature and widely used to fabricate synthetic biomaterials. Selective coassembly of peptide pairs A and B with complementary partial charges is gaining interest due to its potential for expanding the form and…
Spinodal demixing into two phases having very different viscosities leads to viscoelastic networks—i.e., gels—usually as a result of attractive particle interactions. Here, however, we demonstrate demixing in a colloidal system of polydisperse, rod-like clay particles that is driven by particle repulsions instead. One of the phases is a nematic liquid…
Everyone suffers from sarcopenia: the loss of muscle mass and strength due to age. While there are numerous benefits to exercise, an important one is remaining independent well into old age. Weightlifting is essential for keeping muscle mass and strength as the decades go by. The myriad benefits of exercise are well-documented. From physical strength and emotional control , to warding off cogniti
Researchers suggest that a previously unidentified factor may drive whales to migrate. KillerWhales.jpg Killer whales in the waters of Antarctica's Gerlache Strait Image credits: robert mcgillivray/Shutterstock Creature Tuesday, February 18, 2020 – 15:45 Jesse Kathan, Contributor (Inside Science) — Many whale species thrive in the frigid waters of the poles, which are more abundant in fish and
The study, which focused on the federal elections in Germany held in 2013 and 2017, involved Toni Rodon, professor at the Department of Political and Social Sciences at UPF, together with researchers from the London School of Economics and Political Science.
The research report 'Refugee Protection in Germany' by the EU project 'Multilevel Governance of Migration (RESPOND)' paints a gloomy picture of the human rights protection for asylum seekers in Germany. Among other things, the authors speak of a 'differential exclusion' of ever larger groups from German asylum law on the basis of more or less arbitrary criteria. Professor Sabine Hess from the Univ
Northwestern University researchers have, for the first time, determined the 3-D atomic structure of a key complex in paramyxoviruses, a family of viruses that includes measles, mumps, human parainfluenza and respiratory syncytial virus (RSV).
Aussie Space Robots The Western Australian government has announced the opening of a brand new nationally-funded space robotics center as part of a partnership with NASA, in Perth, Australia. Technology developed there could pave the way for remotely operated robots that are capable of constructing a new space station orbiting the Moon, according to WAtoday . "Almost everything in the new mission
For humans, trade is second nature and civilizations have flourished and fallen with the fate of their trade. In fact, the mutual scratching of backs is a cornerstone of many animal societies. On the other hand, deep and sustained mutualisms across species were long thought to be quirks of evolution, where radically different players managed to stick together and trade for mutual benefit. Famous e
Become a latte artist. (Kukuh Pangestu Adhi via Unsplash/) Some coffee drinks cost more than a breakfast sandwich. Yet who can resist the delicious combination of espresso and milk that offers what we need to get us through another work day. Can you put a price on a drink that starts to taste like hope? You can, apparently, and it's rapidly approaching $6. Fortunately, making your espresso drinks
The protein β-arrestin-2 increases the accumulation of brain-damaging tau tangles, a cause several forms of dementia, by interfering with removal of excess tau from the brain, a new study by the University of South Florida Health (USF Health) Morsani College of Medicine found. The research suggests a new treatment approach that could be preventive for those at risk or with mild cognitive impairmen
BGI has a talk next week at a major sequencing meeting claiming $100 for a genome — I will not be there but am very curious how plausible this is & what Illumina's response will be. submitted by /u/remotemass [link] [comments]
The manipulation of liquid droplets demonstrates great importance in various areas from laboratory research to our daily life. Here, inspired by the unique microstructure of plant stomata, we present a surface with programmable wettability arrays for droplets manipulation. The substrate film of this surface is constructed by using a coaxial…
Ever wonder how mice talk to each other. We don't have a dictionary quite yet, but UD neuroscientist Josh Neunuebel and his lab have linked mice chatter (their ultrasonic vocalizations) with specific behaviors. It's a significant advance of our understanding of communication science.
Störningar i betalsystemlösningar är inte bara bankernas problem. Störningarna visar också på vikten av butikernas beredskap för betalsystemstörningar, enligt forskning vid Högskolan i Skövde. De omfattande it-problemen som nyligen drabbade Swedbank visar hur sårbart vårt samhälle är för störningar. Vi kan inte handla mat, tanka bilen eller hämta ut mediciner. Debatten kretsar i stor utsträckning
Yvonne Chen engineers immune cells to target their most evasive enemy: cancer. New cancer immunotherapies generate immune cells that are effective killers of blood cancers, but they have a hard time with solid tumors.
Early detection and rapid response are crucial to avoid severe epidemics of exotic pathogens. However, most detection methods (molecular, serological, chemical) are logistically limited for large-scale survey of outbreaks due to intrinsic sampling issues and laboratory throughput. Evaluation of 10 canines trained for detection of a severe exotic phytobacterial arboreal…
Actin is a major cytoskeletal protein that plays crucial roles in a number of biological events involving force generation and shape changes. Actin monomers are polymerized into actin filaments, which serve as a core of the actin cytoskeleton together with many associated proteins. Although purified actin can be spontaneously polymerized…
Advances in immunotherapy have revolutionized the treatment of multiple cancers. Unfortunately, tumors usually have impaired blood perfusion, which limits the delivery of therapeutics and cytotoxic immune cells to tumors and also results in hypoxia—a hallmark of the abnormal tumor microenvironment (TME)—that causes immunosuppression. We proposed that normalization of TME using…
The complications of measles can be many and varied, and more serious than people might realise, doctors have warned in the journal BMJ Case Reports after treating a series of adults with the infection.
Allostery can be manifested as a combination of repression and activation in multidomain proteins allowing for fine tuning of regulatory mechanisms. Here we have used single molecule fluorescence resonance energy transfer (smFRET) and molecular dynamics simulations to study the mechanism of allostery underlying negative cooperativity between the two agonists glutamate…
Homeostasis of cellular fluxes of inorganic phosphate (Pi) supervises its structural roles in bones and teeth, its pervasive regulation of cellular metabolism, and its functionalization of numerous organic compounds. Cellular Pi efflux is heavily reliant on Xenotropic and Polytropic Retrovirus Receptor 1 (XPR1), regulation of which is largely unknown. We…
IBS scientists have developed a new optogenetic tool to visualize and control the position of specific messenger RNA (mRNA) molecules inside living cells. Using this approach, published in Nature Cell Biology and the research highlights section of Nature Reviews Genetics, the authors revealed something new about cell migration that could not have been discovered with previously available methods.
Labs around the world are racing to develop new computing and sensing devices that operate on the principles of quantum mechanics and could offer dramatic advantages over their classical counterparts. But these technologies still face several challenges, and one of the most significant is how to deal with "noise"—random fluctuations that can eradicate the data stored in such devices.
PLANT BIOLOGY Correction for "BBX4, a phyB-interacting and modulated regulator, directly interacts with PIF3 to fine tune red light-mediated photomorphogenesis," by Yueqin Heng, Yan Jiang, Xianhai Zhao, Hua Zhou, Xuncheng Wang, Xing Wang Deng, and Dongqing Xu, which was first published November 27, 2019; 10.1073/pnas.1915149116 (Proc. Natl. Acad. Sci. U.S.A….
BIOCHEMISTRY Correction for "Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS," by Jin-Zheng Wang, Yongxing Lei, Yanmei Xiao, Xiang He, Jiubo Liang, Jishan Jiang, Shangzhi Dong, Haiyan Ke, Patricia Leon, Philipp Zerbe, Youli Xiao, and Katayoon Dehesh, which was first published December 26, 2019; 10.1073/pnas.1916434117 (Proc. Natl. Acad….
Finding new semiconductor materials that emit light is essential for developing a wide range of electronic devices. But making artificial structures that emit light tailored to our specific needs is an even more attractive proposition. However, light emission in a semiconductor only occurs when certain conditions are met. Today, researchers from the University of Geneva (UNIGE), Switzerland, in co
Making artificial structures that emit light tailored to our specific needs is an even more attractive proposition. However, light emission in a semi-conductor only occurs when certain conditions are met. Researchers (UNIGE) have discovered an entire class of two-dimensional materials that are the thickness of one or a few atoms. When combined together, these atomically thin crystals are capable o
A new study has found that cultivated foods offer chimpanzees in West Africa more energetic benefits than wild foods available in the region. The findings have made a significant development for our further understanding into human-primate coexistence and can help to inform conservation efforts for future improvement, particularly in locations where agricultural expansion is encroaching on tropica
The aetosaurs were heavily armored reptiles that lived in many parts of the world in the Triassic period, some 225 million years ago. For the first time, a student at the University of Bristol has CT scanned a specimen to understand how the armor worked.
Make it easier to eat your veggies. (Depositphotos/) Cooking show chefs are masters of illusion. We feel like we are watching someone quickly and easily prepare a meal, yet the preparation between each step is edited out for a seamless experience without any of the tedium of slicing and chopping. The closest us home chefs can get to TV magic is a good food processor, which grinds, chops, peels, g
In a new research paper, ;Phantom of the ADAS,' the researchers demonstrated that autopilots and advanced driving-assistance systems (ADASs) in semi-autonomous or fully autonomous cars register depthless projections of objects (phantoms) as real objects. They show how attackers can exploit this perceptual challenge to manipulate the vehicle and potentially harm the driver or passengers without any
Nature, Published online: 17 February 2020; doi:10.1038/d41586-020-00461-2 Take a rare look inside the world's largest neutrino detector, the world's most advanced gravitational-wave detector and the experiment that could revolutionize particle physics. Plus, dozens of COVID-19 coronavirus clinical trials take off in China and reintroduced bison churn up bones of their ancestors in Canada.
The balance between sources and sinks of molecular oxygen in the oceans has greatly impacted the composition of Earth's atmosphere since the evolution of oxygenic photosynthesis, thereby exerting key influence on Earth's climate and the redox state of (sub)surface Earth. The canonical source and sink terms of the marine oxygen…
In a study published in the American Heart Association scientific journal Circulation, Kaiser Permanente research scientists report a steady decline in heart attacks for both men and women enrolled in the health system from 2000 to 2014, although that rate of decline slowed among women in the last 5 years of the study.
HIV-1 proviruses persist in the CD4+ T cells of HIV-infected individuals despite years of combination antiretroviral therapy (cART) with suppression of HIV-1 RNA levels <40 copies/mL. Greater than 95% of these proviruses detected in circulating peripheral blood mononuclear cells (PBMCs) are referred to as "defective" by virtue of having large…
Today, at a European Parliament lunch debate, Alzheimer Europe launched a new report presenting the findings of its collaborative analysis of recent prevalence studies and setting out updated prevalence rates for dementia in Europe. The report findings show that, despite a marked reduction in the prevalence of dementia, the number of people with dementia is nonetheless set to double by 2050.
Antibody-based therapies are a promising treatment option for managing ebolavirus infections. Several Ebola virus (EBOV)-specific and, more recently, pan-ebolavirus antibody cocktails have been described. Here, we report the development and assessment of a Sudan virus (SUDV)-specific antibody cocktail. We produced a panel of SUDV glycoprotein (GP)-specific human chimeric monoclonal antibodies…
5-Methylcytosine (m5C) is a RNA modification that exists in tRNAs and rRNAs and was recently found in mRNAs. Although it has been suggested to regulate diverse biological functions, whether m5C RNA modification influences adult stem cell development remains undetermined. In this study, we show that Ypsilon schachtel (YPS), a homolog…
Excitability—a threshold-governed transient in transmembrane voltage—is a fundamental physiological process that controls the function of the heart, endocrine, muscles, and neuronal tissues. The 1950s Hodgkin and Huxley explicit formulation provides a mathematical framework for understanding excitability, as the consequence of the properties of voltage-gated sodium and potassium channels. The Hodg
Cellular integrity is critically dependent on maintaining protein homeostasis. Proteotoxic stresses challenging this balance elicit regulated protective responses essential for organismal fitness. Approximately one-third of synthesized proteins are secreted from cells and undergo biogenesis in the endoplasmic reticulum (ER). Upon import into the ER, these proteins are engaged by chaperone…
Kvaliteten på ett lands dricksvatten beror ofta på om samhället är korrupt eller inte. En studie från Göteborgs universitet visar att demokratier med en dysfunktionell statsförvaltning är lika dåliga på att tillhandahålla rent vatten som auktoritära regimer. En vanlig uppfattning är att demokratier är bättre än andra styrelseskick på att förse medborgarna med grundläggande samhällstjänster som ex
In the nutrient-rich region surrounding marine phytoplankton cells, heterotrophic bacterioplankton transform a major fraction of recently fixed carbon through the uptake and catabolism of phytoplankton metabolites. We sought to understand the rules by which marine bacterial communities assemble in these nutrient-enhanced phycospheres, specifically addressing the role of host resources in…
Dinosaurs were warm-blooded, according to a new technique that analyzes the chemistry of dinosaur eggshells. "Dinosaurs sit at an evolutionary point between birds, which are warm-blooded, and reptiles, which are cold-blooded. Our results suggest that all major groups of dinosaurs had warmer body temperatures than their environment," says lead author Robin Dawson, a postdoctoral research associate
Sundhedsminister Magnus Heunicke (S) og hans embedsfolk får kritik for svar om nedlæggelsen af tusindvis af sengepladser. Ifølge Heunicke følger han bare vejledningen fra ministeriets ekspertpanel – men den forklaring afvises af ministerens egen ekspert.
Tailoring care for older patients who have had emergency surgery can reduce complications and deaths, decrease the length of hospital stays and cut down on the need for alternate care at discharge, according to a new study led a University of Alberta researcher.
Nature Communications, Published online: 18 February 2020; doi:10.1038/s41467-020-14756-5 New design principles for bridging the photoluminescence and electroluminescence of colloidal quantum dots are needed. In this work, the authors report electrochemically-inert ligands as a general material-design strategy for realizing high-performance LEDs based on quantum dots.
Underwhelming When Microsoft founder Bill Gates announced that he had bought Porsche's Taycan electric car, Tesla CEO Elon Musk took to Twitter to disparage his fellow billionaire. "My conversations with Gates have been underwhelming," Musk tweeted , in response to an account that had mused about why Gates had chosen a Porsche over a Tesla. Context Collapse As Bloomberg pointed out , Gates also p
The Quote Via TechCrunch , Elon Musk, Monday night, on Twitter (of course): All orgs developing advanced AI should be regulated, including Tesla — Elon Musk (@elonmusk) February 17, 2020 The Context Musk was responding to a massive feature story published in the MIT Technology Review about OpenAI , the AI research lab founded in part by Elon Musk, alongside others. The lab operates with the missi
The substrate for ribosomes actively engaged in protein synthesis is a ternary complex of elongation factor Tu (EF-Tu), aminoacyl-tRNA (aa-tRNA), and GTP. EF-Tu plays a critical role in mRNA decoding by increasing the rate and fidelity of aa-tRNA selection at each mRNA codon. Here, using three-color single-molecule fluorescence resonance energy…
The Endocrine Society today announced an update to its osteoporosis Clinical Practice Guideline to include recommendations for romosozumab, a new medication that was approved last year to treat postmenopausal women at high risk of fracture.
PLUS. Energistyrelsen forventer, at der vil være over syv gange så mange elbiler indregistreret på de danske landeveje i 2025 som i dag. Men det er ganske enkelt urealistisk med den nuværende lovgivning, lyder det fra eksperter.
How much free energy is irreversibly lost during a thermodynamic process? For deterministic protocols, lower bounds on energy dissipation arise from the thermodynamic friction associated with pushing a system out of equilibrium in finite time. Recent work has also bounded the cost of precisely moving a single degree of freedom….
Nature Communications, Published online: 18 February 2020; doi:10.1038/s41467-020-14798-9 Long-standing radical species have raised noteworthy concerns in organic chemistry and but there remains a substantial challenge to produce long-standing radicals by light. Here, the authors demonstrate a stable dithienylethene derived photochromic radical for detection of peroxides and ozone.
Nature Communications, Published online: 18 February 2020; doi:10.1038/s41467-020-14768-1 Applications of quantum information processing require distribution of quantum states for linking nodes in networks and mechanical oscillators can create versatile links. Here, the authors describe continuous variable entanglement between two optical modes mediated by a mechanical oscillator.
New Australian technology that could fix some of the world's biggest environmental pollution problems — oil spills, mercury pollution and fertiliser runoff — will soon be available to global markets following the signing of a landmark partnership with Flinders University.
Using ESO's Very Large Telescope (VLT), astronomers have captured the unprecedented dimming of Betelgeuse, a red supergiant star in the constellation of Orion. The stunning new images of the star's surface show not only the fading red supergiant but also how its apparent shape is changing.
Autoxidation is an autocatalytic free-radical chain reaction responsible for the oxidative destruction of organic molecules in biological cells, foods, plastics, petrochemicals, fuels, and the environment. In cellular membranes, lipid autoxidation (peroxidation) is linked with oxidative stress, age-related diseases, and cancers. The established mechanism of autoxidation proceeds via H-atom abstrac
2018 Nissan Leaf Fans of EVs say reliability is part of their charm: no combustion engine, fewer moving parts, no muffler or catalytic converter, less wear and tear on the brakes. Now there's proof from the most recent JD Power Vehicle Dependability Study: The Nissan Leaf (main photo) ranks as the most reliable car in its class and two other EVs, the BMW i3 and the Chevrolet Bolt EV, are in the t
Sound on. (Depositphotos/) Although televisions have advanced by leaps and bounds in most departments—it's difficult to find a set that isn't an 4K smart TV with a multitude of built-in streaming apps—they still tend to lag in the sound department. The internal speakers of most TVs just aren't up to the level of the visuals. Perhaps it's because the makers assume you'll be looking to bring in a l
Competitive behavior among employees may be triggered by the type of feedback they have received. These are the findings of a study conducted by the Max Planck Institute for Human Development and the IESE Business School in Barcelona. The results have been published in the Journal of Behavioral Decision Making.
The Swedish Malaise Trap Project (SMTP) was launched in 2003 with the aim of making a complete list of the insect diversity of Sweden. Over the past fifteen years, an estimated total of 20 million insects, collected during the project, have been processed for scientific study. Recently, the team behind this effort published the resulting inventory in the open-access journal Biodiversity Data Journ
Abilities to cultivate or manage members of other species evolved repeatedly, and in a few taxa the managed symbionts were domesticated, representing one of the great innovations in evolution (1, 2), one which transformed human history (3, 4). For early farmers, to what extent were agricultural practices tailored to local…
Cancer patient's immature eggs were collected, matured in lab and frozen for use five years on A woman who was left infertile by cancer treatment has given birth to a baby after her immature eggs were collected, matured in a lab and frozen for use five years later. Fertility specialists at Antoine Béclère University hospital in Clamart near Paris said the healthy boy, named Jules, was the first b
A fireball in the sky, accompanied by a bang, amazed hundreds of eyewitnesses in northern Germany in mid-September last year. The reason for the spectacle was a meteoroid entering the Earth's atmosphere and partially burning up. Planetologists have been studying a part of the meteorite. They found out that the meteorite contains minerals that formed under the presence of water on small planetesima
First measurements by a Solar Orbiter science instrument reached the ground on Thursday 13 February providing a confirmation to the international science teams that the magnetometer on board is in good health following a successful deployment of the spacecraft's instrument boom.
Salmon and steelhead could once again inhabit more than 100 miles of the upper Green River watershed now that the entire Washington congressional delegation has backed restarting a federal project to allow fish to pass the Howard Hanson Dam.
When you think of fangirls, what comes to mind: large swaths of fandom (usually for a boyband) whose feelings culminate in tears and joyful screams? Perhaps you grimace or roll your eyes at the thought. In this fun, lively talk, playwright Yve Blake asks us to reevaluate our reaction to the misunderstood passion and power of fangirls, emphasizing why we should all embrace our own unbridled enthusi
When a colloidal suspension is dried, capillary pressure may overwhelm repulsive electrostatic forces, assembling aggregates that are out of thermal equilibrium. This poorly understood process confers cohesive strength to many geological and industrial materials. Here we observe evaporation-driven aggregation of natural and synthesized particulates, probe their stability under rewetting, and…
During development, neural progenitors change their competence states over time to sequentially generate different types of neurons and glia. Several cascades of temporal transcription factors (tTFs) have been discovered in Drosophila to control the temporal identity of neuroblasts, but the temporal regulation mechanism is poorly understood in vertebrates. Mammalian retinal…
The ability to sustain attention differs across people and changes within a single person over time. Although recent work has demonstrated that patterns of functional brain connectivity predict individual differences in sustained attention, whether these same patterns capture fluctuations in attention within individuals remains unclear. Here, across five independent studies,…
Förstelärarreformen skulle göra läraryrket attraktivt och höja elevers resultat på sikt. Den omdebatterade reformen infördes 2013, och innebar att ett antal lärare hos varje skolhuvudman skulle utses till förstelärare. Uppdraget innebar i korthet ett större ansvar för att utveckla undervisningen och ett lönelyft på 5000 kronor i månaden.
More organization at the molecular level could improve the efficiency of membranes used in the hydrogen fuel cells that provide energy to electric cars and other industrial applications, according to a review published in the journal Science and Technology of Advanced Materials.
Researchers at Karolinska Institutet in Sweden and the University of Milan in Italy have identified a gene in human neurons that protects against the degeneration of motor neurons in the deadly diseases ALS and SMA. Gene therapy in animal models of these diseases was shown to protect against cell death and increase life expectancy. The study is published in the eminent journal Acta Neuropathologic
Financial markets are among the most well-studied and closely watched complex systems in existence. This rich literature on market modeling and analysis has led to many important innovations, such as automated tools for detecting market manipulation. But a large gap still exists between the current state-of-the-art and the powerful insights needed to fully understand the complex dimensions of mark
Scientists at Tokyo Institute of Technology designed a new type of controller for the robotic arm used in robotic surgery. Their controller combines the two distinct types of gripping used in commercially available robotic systems to leverage the advantages of both, reducing the efforts of the surgeon and providing good precision.
When unpasteurized milk is used to make cheese, the result is a product with more complex flavors, meaning many consumers seek out cheese made from "raw" milk. However, if the milk was contaminated, the cheese it's used for can harbor pathogens that make people sick. This is where "protective cultures" can help.
Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-associated macrophages and microglia (TAMs), which are key mediators of immune suppression and resistance to immunotherapy. We and others demonstrated aberrant expression of glycans in different cancer types. These…
Researchers at North Carolina State University have demonstrated a new, green technology for both accelerated screening and retrieving "switchable" solvents used in green chemistry applications. The new approach makes the screening process hundreds of times faster and drastically accelerates the rate at which solvents can be retrieved from solution.
A new study in the American Journal of Primatology highlights the critical need for conservation efforts to protect lemurs on Madagascar. This unique ecosystem is home to more than 110 species of lemurs, but approximately 95 percent are threatened with extinction, making them the most vulnerable mammal group on Earth.
Brace yourself, correctly. (Depositphotos/) If you've sprained a wrist or are dealing with a troublesome knee, you'll want to find a good brace. This is especially true if you're physically active and find that your injury bugs you when you move or play sports. Here we've compiled a list of ace braces for a variety of ailments and pains. Tried and true. (Amazon /) If you've ever sprained a joint,
Researchers conclude that improved inhaler technique and adherence are one of multiple factors contributing to long-term COPD outcomes, but their research has confirmed one technique–use of lay health coaches–that may help patients get optimal benefit from their COPD medications.
Heated tobacco devices — which heat rather than burn tobacco to create a vapor — are the next products being pushed by the tobacco industry. A new study finds that the products are making inroads among young adults, with some users saying they have never used other tobacco products.
Air doesn't stay contained within state lines (JuniperPhoton/) Air pollution isn't just a local problem. Tailpipe emissions within a city affect the lungs of those living in the vicinity, but wind can also carry particles like ozone and particulate matter into the airways of people hundreds of miles away. A new study, published Wednesday in Nature , reveals just how much pollution the Lower 48 st
People rely on a highly tuned sense of touch to manipulate objects, but injuries to the skin and the simple act of wearing gloves can impair this ability. In this week's Applied Physics Reviews, scientists report the development of a new tactile-enhancement system based on a highly sensitive sensor. The sensor has remarkable sensitivity, allowing the wearer to detect the light brush of a feather.
Transition from laminar to turbulent flow occurring over a smooth surface is a particularly important route to chaos in fluid dynamics. It often occurs via sporadic inception of spatially localized patches (spots) of turbulence that grow and merge downstream to become the fully turbulent boundary layer. A long-standing question has…
Accurate analysis of blood concentration and circulation half-life is an important consideration for any intravenously administered agent in preclinical development or for therapeutic application. However, the currently available tools to measure these parameters are laborious, expensive, and inefficient for handling multiple samples from complex multivariable experiments. Here we describe a…
Results from the NRG Oncology clinical study NRG-CC001 concluded that lowering radiotherapy dose to hippocampal stem cells improves cognitive and patient-reported outcomes for patients with brain metastases.
Holstein steers that get hormone implants grow faster than those that do not receive the implants, and they get as big as beef cattle breeds, according to Penn State researchers, who say that's good news for dairy farmers struggling to keep their operations financially viable.
Patients' ratings of hospitals and willingness to recommend them have almost no correlation to the quality of medical care provided or to patient survival rates, according to new Cornell University research.
Having more nurses trained outside of the United States working on a hospital unit does not hurt collaboration among healthcare professionals and may result in a more educated and stable nursing workforce, finds a new study by researchers at NYU Rory Meyers College of Nursing published in the journal Nursing Economic$.
A study of gliding animals has challenged the idea that evolutionary innovations—adaptations that bring new abilities and advantages—spur the origin of other new body types and other characteristics in descendent species. The research, undertaken by evolutionary biologists at UNSW Sydney and universities in the US and Spain, examined the key innovation of gliding in two types of gliding animals: '
An international team of researchers carried out an experiment at HSE University demonstrating that knowledge of several languages can improve the performance of the human brain. In their study, they registered a correlation between participants' cognitive control and their proficiency in a second language.
Combining experiment and theory, researchers from the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy (MBI) and the Max Planck Institute of Microstructure Physics have disentangled how laser pulses can manipulate magnetization via ultrafast transfer of electrons between atoms.
Low oxygen levels in the heart have long been known to produce life-threatening arrhythmias, even sudden death. Until now, it was not clear how. New findings reveal the underlying mechanism for this dangerous heart disorder.
Increased expression of extracellular matrix (ECM) proteins in circulating tumor cells (CTCs) suggests potential function of cancer cell-produced ECM in initiation of cancer cell colonization. Here, we showed that collagen and heat shock protein 47 (Hsp47), a chaperone facilitating collagen secretion and deposition, were highly expressed during the epithelial-mesenchymal transition…
Up In Smoke As if living with a carbon footprint wasn't a nuisance enough, it turns out the way you leave your life can have an impact on the Earth as well. One new funeral option: Human composting, which is exactly what it sounds like, is becoming more available, and according to a recent interview in the BBC, it may be better for the environment as well. Carbon Foot-print In May 2019, Washingto
MutL proteins are ubiquitous and play important roles in DNA metabolism. MutLγ (MLH1–MLH3 heterodimer) is a poorly understood member of the eukaryotic family of MutL proteins that has been implicated in triplet repeat expansion, but its action in this deleterious process has remained unknown. In humans, triplet repeat expansion is…
A top ten of record-breaking US weather events of the last decade reveals Hurricane Harvey is the most extreme of the decade, and similar others were among the costliest and deadliest on record, according to magazine Weatherwise.
If we throw all those organ planting, blood transfer and those stem cells therapies into one human being, is it already enough for him to live forever if we ignore fetal accidents. submitted by /u/853240936 [link] [comments]
Dams contribute to water security, energy supply, and flood protection but also fragment habitats of freshwater species. Yet, a global species-level assessment of dam-induced fragmentation is lacking. Here, we assessed the degree of fragmentation of the occurrence ranges of ∼10,000 lotic fish species worldwide due to ∼40,000 existing large dams…
Parental speaking style and child language development Parentese influences language development in infants. Image courtesy of Pixabay/ReadyElements. Across cultures, adults often use "parentese," a speaking style characterized by exaggerated intonation, high pitch, and slow tempo, when interacting with young children. Previous studies have suggested that children who hear more parentese…
The amygdala is central to the pathophysiology of many psychiatric illnesses. An imprecise understanding of how the amygdala fits into the larger network organization of the human brain, however, limits our ability to create models of dysfunction in individual patients to guide personalized treatment. Therefore, we investigated the position of…
Calcified minerals in biogenic materials often play a utilitarian role, such as structural supports in bone, teeth, and shells, where the crystals are arranged in well-ordered arrays (1, 2). The ability of organisms to produce single crystalline scaffolds and hierarchical architectures with unique features, such as bent or spheroidal shapes,…
Even though they don't have conventional noses, insects have adapted to smell odors in nearly every imaginable niche. Mosquitoes find us by our odor molecules binding to odor receptors on their antennae, bees are drawn to flowers the same way, whereas ticks detect an approaching host using receptors on their forelegs. Insects' ability to smell is uniquely adapted to their needs and habitats and Va
In both Turner syndrome (TS) and Klinefelter syndrome (KS) copy number aberrations of the X chromosome lead to various developmental symptoms. We report a comparative analysis of TS vs. KS regarding differences at the genomic network level measured in primary samples by analyzing gene expression, DNA methylation, and chromatin conformation….
Researchers in China led by Lilin Yi at Shanghai Jiao Tong University developed apparatus and software algorithms allowing automatic 'intelligent control' over the femtosecond pulses generated by mode-locked fiber lasers. The system can manipulate key aspects of the wavelength range and composition of the pulses – technically their 'spectral width' and 'spectral shape' — more effectively than pre
An Indiana University cancer researcher has identified eight new genomic regions that increase a person's risk for skin cancer. Jiali Han, Ph.D., and colleagues discovered eight new loci–locations on a person's genome–that are susceptible to the development of squamous cell skin cancer.
Siffran kan låta oroväckande: 45 procent ökad risk att dö under första året för barn som kommit till genom in vitro-fertilisering, IVF. – Men man ska komma ihåg att risken ändå är mycket liten, säger Kenny Rodriguez-Wallberg, forskare i reproduktionsmedicin vid Karolinska institutet i Solna. Sverige är ett av länderna i världen med lägst spädbarnsdödlighet, drygt två dödsfall per tusen födda. Så d
Children conceived with assisted reproductive techniques including IVF have a somewhat higher mortality risk during their first weeks of life than children conceived naturally, according to a study by researchers at Karolinska Institutet in Sweden published in the journal Fertility and Sterility. The researchers link the increased risk to a higher degree of premature births in IVF children and emp
Contributor is a science journalist based in Santa Cruz, California. They hold a bachelors in wildlife biology from the University of California, Davis and is currently completing a masters in science communication at the University of California, Santa Cruz. When not writing, they like reading science fiction and making soup. Follow them on twitter @jessekathan . Author social media Twitter Aut
DURHAM, N.C.—John Bolton has been called many things over his long career, plenty of them unflattering, but he has seldom been accused of being bashful about stating his opinions. Yet in an interview at Duke University on Monday, his first public remarks since the impeachment inquiry into President Trump began, the former national-security adviser tried something new: saying as little as possible
The Journal of the American Heart Association (JAHA) today retracted a paper it published last year claiming that vaping was linked to heart attacks. The paper, by Dharma Bhatta and Stanton Glantz of the University of California, San Francisco, has faced a barrage of criticism since its publication last June — and Glantz's claims, in … Continue reading
Kidney patients benefit by accepting kidneys from donors with hepatitis C, according to a University of Cincinnati physician-researcher. Making the choice reduces organ wait time for kidney patients while saving money over the long run. It also improves the quality of life and life expectancy for kidney patients.
The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K+ channels in the sarcolemma. Opening of Kv2.1 channels causes membrane hyperpolarization, which decreases the activity of L-type CaV1.2 channels, lowering intracellular Ca2+ ([Ca2+]i) and causing smooth muscle relaxation. A limitation of this model is…
Storing image files in mixtures containing custom-synthesized small molecules is a milestone for molecular data storage, researchers report. In all, the researchers stored more than 200 kilobytes of data, which they say is the most stored to date using small molecules. That's not a lot of data compared to traditional means of storage, but it is significant progress in terms of small molecule stor
Experts have been unable to explain why cells from bacteria to humans leak essential chemicals necessary for growth into their environment. New mathematical models reveal that leaking metabolites — substances involved in the chemical processes to sustain life with production of complex molecules and energy — may provide cells both selfish and selfless benefits.
Combining experiment and theory, researchers from the Max Born Institute for Nonlinear Optics and Short Pulse Spectroscopy (MBI) and the Max Planck Institute of Microstructure Physics have disentangled how laser pulses can manipulate magnetization via ultrafast transfer of electrons between different atoms.
In pursuit of 3D visualization of cells and organisms with minimal invasiveness and high spatiotemporal resolution, researchers demonstrated a new form of light-sheet imaging, coined CLAM, which allows scan-free, parallelized 3D fluorescence imaging that results in an even slower rate of photobleaching than scanning light-sheet imaging, yet without sacrificing the image speed and resolution. Readi
While most people know about Rosa Parks' role in the Montgomery bus boycott, women's behind-the-scenes organizing efforts made the boycott successful, an expert explains. "People know about Rosa Parks. People know about Martin Luther King Jr.—and they should. And they know that it was the Montgomery bus boycott that ignited a certain kind of Southern civil rights movement," says Ula Taylor, a pro
The facultative intracellular pathogen Listeria monocytogenes uses an actin-based motility process to spread within human tissues. Filamentous actin from the human cell forms a tail behind bacteria, propelling microbes through the cytoplasm. Motile bacteria remodel the host plasma membrane into protrusions that are internalized by neighboring cells. A critical unresolved…
UCL scientists measured heart rates and sweat glands of audiences and found live shows caused much greater response Science has proved what theatre and concert-goers have long known. When it comes to emotional impact, watching a live performance is so much more thrilling than a version on screen. Scientists from University College London (UCL) measured heart rates and sweat glands of audience mem
sing the Dutch-led Low Frequency Array (LOFAR) radio telescope, astronomers have discovered unusual radio waves coming from the nearby red dwarf star GJ1151. The radio waves bear the tell-tale signature of aurorae caused by an interaction between a star and its planet. The radio emission from a star-planet interaction has been predicted for over thirty-years but this is the first time astronomers
An international team of astronomers has performed a decade-long, multi-wavelength monitoring campaign of the blazar 1ES 1215+303. Results of this extensive study provide more insights into the nature of emission from this source. The research is detailed in a paper published February 10 on arXiv.org.
Study found differences compared with those who did not offend or who only transgressed as adolescents Parents should not worry about their teenagers' delinquent behaviour provided they were well behaved in their earlier childhood, according to researchers behind a study that suggests those who offend throughout their life showed antisocial behaviour from a young age and have a markedly different
A pre-specified secondary analysis of a double-blind placebo-controlled randomized trial found that low-dose methotrexate (LD-MTX) was associated with a small to modest increase in the risk for some adverse events, including skin cancer and gastrointestinal, infectious, pulmonary, and hematologic effects in patients at risk for heart disease. The risk for kidney-related side-effects was decreased.
Exploiting a vulnerability in the mobile communication standard LTE, also known as 4G, researchers at Ruhr-Universität Bochum can impersonate mobile phone users. Consequently, they can book fee-based services in their name that are paid for via the mobile phone bill — for example, a subscription to streaming services.
The matrix-2 (M2) protein from influenza A virus is a tetrameric, integral transmembrane (TM) protein that plays a vital role in viral replication by proton flux into the virus. The His37 tetrad is a pH sensor in the center of the M2 TM helix that activates the channel in response…
Grave in Lincolnshire dates to medieval pandemic of 1348 and reveals rural plague catastrophe A mass grave containing the remains of dozens of victims of the Black Death offers chilling new evidence of the speed and scale of the devastation the plague brought to rural England, according to archaeologists. The grave, discovered in a remote corner of rural Lincolnshire, has been dated to the 14th c
Loud hammering noises like pile driving disrupt the mating behavior of longfin squid, but the cephalopods seem to get acclimated to the incessant noise, according to new research presented at the Ocean Sciences Meeting this week.
An approach based on artificial intelligence (AI) may allow EKGs to be used to screen for hypertrophic cardiomyopathy in the future. With hypertrophic cardiomyopathy, the heart walls become thick and may interfere with the heart's ability to function properly. The disease also predisposes some patients to potentially fatal abnormal rhythms. Current EKG technology has limited diagnostic yield for t
Soot emissions in combustion are unwanted consequences of burning hydrocarbon fuels. The presence of soot during and following combustion processes is an indication of incomplete combustion and has several negative consequences including the emission of harmful particulates and increased operational costs. Efforts have been made to reduce soot production in…
Nature Communications, Published online: 18 February 2020; doi:10.1038/s41467-020-14622-4 In insects, Y chromosome-linked male determining factor can determine sex, but the sex determination factor of the Oriental Fruit fly is unknown. Here the authors show that an autosomal-derived miR-1-3p is enriched in males, suppressing the expression of Bdtra, which is required for female sex determination.
The ecological niche of a species describes the variation in population growth rates along environmental gradients that drives geographic range dynamics. Niches are thus central for understanding and forecasting species' geographic distributions. However, theory predicts that migration limitation, source–sink dynamics, and time-lagged local extinction can cause mismatches between niches and…
Ground-penetrating radar may soon be the sensor that makes your car autonomous in all weather conditions. It turns out that when you scan the 10 feet below the roadway surface, you get a unique identifier that is accurate to an inch or two. Mapping cars would scan the roadways once, then your self-driving car with its own ground-penetrating radar would rescan as you drive, matching its real-time
University of Kent research has found that moderate intensity exercise such as brisk walking, water aerobics or cycling can have the most beneficial effect on memory performance. These findings suggest that it is not necessary for people to carry out highly strenuous exercise to achieve observable improvements in long-term memory, as moderate exercise can have a more positive influence.
A magnetic monopole is a theoretical particle with a magnetic charge. Give it an electric charge, and you get another theoretical beast, dubbed a dyon. Many "grand unified theories" of particle physics, which connect fundamental forces at high energies into a single force, predict the existence of dyons, but no experiments at particle accelerators have so far searched for these hybrid particles—un
For decades, research examining the intersection of religion and politics counted the religious "nones"—or the unaffiliated—as a small, homogeneous and liberal group, and conservatives have treated them as such.
A new study in JNCI: Journal of the National Cancer Institute, published by Oxford University Press, finds significant benefits to lengthening the amount of time between prostate cancer screenings for men.
Thoughts, sensations, and emotions zap across the brain via a meshwork of fine nerve fibers called axons. Axon size is crucially important for general brain function as well as in certain neurological conditions. Experts have been striving to establish a means to noninvasively measure these fibers for many years. An international team of researchers has now developed a novel MRI method that manage
A virus has been found whose DNA is 90% absolutely unfamiliar. Scientists have no real idea what it developed from, or how. Viruses used to be thought of as simple, jumbles of things — not so much any more. In Lake Pampulha in the Brazilian city of Belo Horizonte, scientists found an amoeba virus unlike anything seen before. Named after Yara , the mother of waters in Brazilian mythology, 90 perce
Causes for miscarriages and congenital malformations can be genetic, environmental, or a combination of both. Genetic variants, hypoxia, malnutrition, or other factors individually may not affect embryo development, however, they may do so collectively. Biallelic loss-of-function variants in HAAO or KYNU, two genes of the nicotinamide adenine dinucleotide (NAD) synthesis…
The demand for laser-resistant mirror coatings is increasing in inertial confinement fusion, extreme light infrastructure and other laser applications. The ideal UV laser mirror (UVLM) coating requires high reflectivity with large bandwidth and high laser-induced damage threshold (LIDT). Unfortunately, these requirements are difficult to satisfy simultaneously. This is due, for example, to the fac
Winds outside of Tropical Storm Gabekile are ripping the storm apart. NASA's Aqua satellite provided a visible image of the storm that showed strong northwesterly wind shear was adversely affecting the storm.
In plants and mammals, DNA methylation plays a critical role in transcriptional silencing by delineating heterochromatin from transcriptionally active euchromatin. A homeostatic balance between heterochromatin and euchromatin is essential to genomic stability. This is evident in many diseases and mutants for heterochromatin maintenance, which are characterized by global losses of…
NCCR MARVEL researchers at EPFL's Chair of Computational Condensed Matter Physics (C3MP) and colleagues have developed an artificial neural network (ANN) model that may serve as a basis for solving inverse problems. Their approach reaches the same level of accuracy as the now commonly used maximum entropy (MaxEnt) method for low-noise data, performs significantly better than this standard techniqu
Scientists have taken a major step toward a circular carbon economy by developing a long-lasting, economical catalyst that recycles greenhouse gases into ingredients that can be used in fuel, hydrogen gas, and other chemicals. The results could be revolutionary in the effort to reverse global warming, according to the researchers.
More portable, fully wireless smart home setups. Lower power wearables. Batteryless smart devices. These could all be made possible thanks to a new ultra-low power Wi-Fi radio developed by UC San Diego engineers. It enables Wi-Fi communication at 5,000 times less power than commercial Wi-Fi radios.
The financial burden on health systems would drastically increase if new European expert guidelines for cholesterol-lowering treatment were implemented, according to a new simulation study by researchers at Karolinska Institutet in Sweden, published in the European Heart Journal. The findings highlight an urgent need for cost-effectiveness analysis given the current cost of the proposed treatment
A multi-institutional group of researchers led by Children's Hospital of Philadelphia (CHOP) has linked a strong cancer driver gene to changes in proteins that regulate alternative splicing. The researchers created new computational tools and biological model systems for the study. This collaborative research, led by Yi Xing, PhD, at CHOP and Owen Witte, MD, at the University of California, Los An
Jupiter's moon Io — the solar system's most volcanic world — has inspired a new way to find distant exoplanets. As the moon orbits Jupiter, it tugs on the planet's magnetic field, generating bright auroras in Jupiter's atmosphere. Even if we couldn't see Io itself, the enormous auroras, pulsing to the beat of a hidden orbiting body, would tell us that something was out there. Scientists have long
New guidelines recommend aspirin use in primary prevention for people ages 40 to 70 years old who are at higher risk of a first cardiovascular event, but not for those over 70. Yet, people over 70 are at higher risks of cardiovascular events than those under 70. As a result, health care providers are understandably confused about whether or not to prescribe aspirin for primary prevention of heart
Genes are like instructions, but with options for building more than one thing. Daniel Larson, senior investigator at the National Cancer Institute, studies this gene "splicing" process, which happens in normal cells and goes awry in blood cancers like leukemia. Larson, postdoctoral associate Yihan Wan, and colleagues developed a new technique to study gene splicing at an unprecedented scale, reve
A new international advisory system is working to keep aircraft crew and passengers safe from space weather impacts, thanks in part to the efforts of a team of CIRES and NOAA developers, forecasters, and scientists in Boulder, Colorado.
The piece of gold that Richard Taylor was thrilled to track down weighed less than a single bacterium. Taylor, a postdoctoral fellow at the Max Planck Institute, was working to follow individual nanogold-labeled molecules that move just nanometers, billionths of a meter. The resulting microscopy technique, developed under Professor Vahid Sandoghdar and colleagues, can follow proteins at microsecon
A multidisciplinary study led by UB researchers has developed a new experimental tool that enables the application of focalized damage on an in vitro neuronal network of only a few millimetres and record the evolution of the whole network. One of the main conclusions is that the network quickly activates self-regulation mechanisms that reinforce the existing connections and restore the functionali
Military service is a risk factor for sleep disorders. Recognizing this, the US Departments of Veterans Affairs and Defense issued new guidelines for assessing and treating insomnia and obstructive sleep apnea in military personnel and veterans.
After years of monitoring the body's microbial communities, researchers are now starting to modify them to treat disease. Put the gut microbes from an obese mouse into the body of a lean one, and the latter will pack on weight—even without changes to its diet, activity, or other habits (1)….
Researchers at the National Institutes of Health found evidence that specific immune cells may play a key role in the devastating effects of cerebral malaria, a severe form of malaria that mainly affects young children. The results, published in the Journal of Clinical Investigation, suggest that drugs targeting T cells may be effective in treating the disease. The study was supported by the NIH I
Human milk oligosaccharides (HMOs) found in breastmilk may influence a child's growth from infancy through early childhood, according to a study supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH).
A pair of researchers at Victoria University of Wellington has found that North Island robins have long-term memory. In their paper published in the journal Biology Letters, Rachael Shaw and Annette Harvey describe experiments they conducted with the birds and what they learned from them.
Imagine a dancer en pointe, spinning on her own axis while dancing on a rotating carousel. She might injure herself when both rotations add up and the angular momentum is transferred. Are similar phenomena also present in quantum mechanical systems?
Stresses that increase the cellular concentration of dinucleoside tetraphosphates (Np4Ns) have recently been shown to impact RNA degradation by inducing nucleoside tetraphosphate (Np4) capping of bacterial transcripts. However, neither the mechanism by which such caps are acquired nor the function of Np4Ns in bacteria is known. Here we report that…
A team of researchers from the NUS Yong Loo Lin School of Medicine has identified a novel protein that would prevent the development of neuropathy, a major side effect of chemotherapy, in cancer patients.
As legend has it, when French workers felt their livelihoods threatened by automation in the early 1900s, they flung their wooden shoes called sabots into the machines to stop them. Hence the word sabotage.
Annual reproductive success and senescence patterns vary substantially among individuals in the wild. However, it is still seldom considered that senescence may not only affect an individual but also affect age-specific reproductive success in its offspring, generating transgenerational reproductive senescence. We used long-term data from wild yellow-bellied marmots (Marmota flaviventer)…
Rods settling under gravity in a quiescent fluid can overcome the bottleneck associated with aggregation of equal-size spheres because they collide by virtue of their orientation-dependent settling velocity. We find the corresponding collision kernel Γrods=lβ1ΔρVrodg/(16Aμ), where l, A, and Vrod are the rods' length, aspect ratio (length divided by width),…
Opioids are some of the most effective and most problematic drugs in the entire pharmacopeia. For severe, intractable pain we really have nothing to match them, despite decades of searching for alternatives. The history of research for new pain medications itself calls for pain medication, because it is a tapestry of expensive late-stage clinical failures. All sorts of receptors, enzymes, ion cha
In a recent article published in Science Bulletin, researchers developed an effective organic-cation intercalation strategy to manipulate the interlayer coupling of layered materials, and obtain a class of organic-inorganic hybrid crystals with tailored topological properties and enhanced superconductivities.
Policies regulating fishing in international waters do not sufficiently protect officials who monitor illegal fishing, the prohibited dumping of equipment, or human trafficking or other human rights abuses, finds a new analysis by a team of environmental researchers.
Unraveling the packing structure of dense assemblies of semiflexible rings is not only fundamental for the dynamical description of polymer rings, but also key to understand biopackaging, such as observed in circular DNA of viruses or genome folding. Here we use X-ray tomography to study the geometrical and topological features…
A pancreatic cancer 'time machine' engineered by Purdue University researchers has revealed that the disease is even more unpredictable than previously thought: cancer cells promote each other's invasiveness when they grow together.
Nature, Published online: 18 February 2020; doi:10.1038/d41586-020-00436-3 As civilization seems to be lurching towards a cliff edge, historical case studies are giving way to big data in authors' search for understanding. By Laura Spinney
Instead of expensive or risky cosmetic surgeries, people are taking a new approach to covering up injuries: "paramedical" tattoos. Tattoo artists have offered post-mastectomy tattoos to breast cancer survivors for years. Now, artists have started expanding outward to other medical procedures, The New York Times reports . A man who lost two fingertips in a workplace got fingernails tattooed on. A
Parental language input is one of the best predictors of children's language achievement. Parentese, a near-universal speaking style distinguished by higher pitch, slower tempo, and exaggerated intonation, has been documented in speech directed toward young children in many countries. Previous research shows that the use of parentese and parent–child turn-taking…
The top contributor to familial Parkinson's disease is mutations in leucine-rich repeat kinase 2 (LRRK2), whose large and difficult structure has finally been solved, paving the way for targeted therapies.
Researchers analyzed incidences of chronic obstructive pulmonary disease (COPD) among adults 35 years and older who were living with and without HIV between 1996 and 2015 in Ontario – where over 40 per cent of Canadians living with HIV reside. People in Ontario living with HIV had a 34 per cent higher incidence rate of COPD and were diagnosed with the disease about 12 years younger than HIV-negati
Thrombin, a procoagulant protease, cleaves and activates protease-activated receptor-1 (PAR1) to promote inflammatory responses and endothelial dysfunction. In contrast, activated protein C (APC), an anticoagulant protease, activates PAR1 through a distinct cleavage site and promotes anti-inflammatory responses, prosurvival, and endothelial barrier stabilization. The distinct tethered ligands form
Nuclei can be round, like a soccer ball, or oblong, like a football. Others are slightly oblong but misshapen, like a potato. One of the only two ways to observe the third shape, rarely encountered, is when the nucleus wobbles like a lopsided top.
l-tryptophan (Trp), an essential amino acid for mammals, is the precursor of a wide array of immunomodulatory metabolites produced by the kynurenine and serotonin pathways. The kynurenine pathway is a paramount source of several immunoregulatory metabolites, including l-kynurenine (Kyn), the main product of indoleamine 2,3-dioxygenase 1 (IDO1) that catalyzes the…
Potato virus Y is the most economically important and devastating aphid-transmitted virus, affecting both tuber yield and quality. The virus is also a major cause of seed potato degeneration, which leads to regular flushing out of seed potatoes after limited field production cycles. There is no remedy for this virus and once a plant becomes infected, it stays sick for life.
Susan P. Harrison, a professor of environmental science and policy at the University of California, Davis (UC Davis), has made seminal contributions to basic, theoretical, and conservation ecology. Her research, which includes studies concerning the spatial dynamics of plant and animal communities, large-scale diversity patterns, natural climatic variability, and anthropogenic…
Exposure to loud sound damages the postsynaptic terminals of spiral ganglion neurons (SGNs) on cochlear inner hair cells (IHCs), resulting in loss of synapses, a process termed synaptopathy. Glutamatergic neurotransmission via α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type receptors is required for synaptopathy, and here we identify a possible involvement of GluA2-lacking Ca2+-pe
During protein degradation by the ubiquitin–proteasome pathway, latent 26S proteasomes in the cytosol must assume an active form. Proteasomes are activated when ubiquitylated substrates bind to them and interact with the proteasome-bound deubiquitylase Usp14/Ubp6. The resulting increase in the proteasome's degradative activity was recently shown to be mediated by Usp14's…
Researchers have examined new geriatric-specific characteristics that appear to raise the risk of elderly surgical patients having an unplanned hospital readmission within a month of initially leaving the hospital.
Personalized medicine offers great potential benefits for disease management but requires continuous monitoring of drugs and drug targets. For instance, the therapeutic window for lithium therapy of bipolar disorder is very narrow, and more frequent monitoring of sodium levels could avoid toxicity. In this work, we developed and validated a…
Paleodietary studies of the fossil record are impeded by a lack of reliable and unequivocal tracers. Scientists from the MPI for Evolutionary Anthropology, the MPI for Chemistry and the Johannes Gutenberg University (JGU) in Mainz have now tested a new method, the isotope analysis of zinc isotopes from the tooth enamel of fossil mammals, and found it to be well suited to expand our knowledge about
Nature Communications, Published online: 18 February 2020; doi:10.1038/s41467-020-14503-w Nonlinear effects have been studied in optical fiber communications channels under various specified parameter regimes. Here, the authors develop an approximate model via perturbation that is more accurate for the highly nonlinear regime.
High levels of ultrafine particles (UFPs; diameter of less than 50 nm) are frequently produced from new particle formation under urban conditions, with profound implications on human health, weather, and climate. However, the fundamental mechanisms of new particle formation remain elusive, and few experimental studies have realistically replicated the relevant…
Modified vaccinia virus Ankara (MVA), a widely used vaccine vector for expression of genes of unrelated pathogens, is safe, immunogenic, and can incorporate large amounts of added DNA. MVA was derived by extensively passaging the chorioallantois vaccinia virus Ankara (CVA) vaccine strain in chicken embryo fibroblasts during which numerous mutations…
If the heart muscle is damaged, repairing the constantly active organ is a challenge. Empa researchers are developing a novel tissue adhesive inspired by nature, which is able to repair lesions in muscle tissue. They have taken advantage of the incredible ability of marine mussels to adhere to any kind of surface.
We thank Tran et al. (1) for their appreciation of our open innovation platform (https://opnme.com/) and interest in our manuscript (2) in which we demonstrate that the small-molecule KRAS inhibitor BI-2852 reduces pERK (EC50 = 6 µM) and inhibits proliferation (EC50 = 7 µM) in NCI-H358 cells. Tran et al….
Weihmann's (1) comment on our recent paper (2) presents a misunderstanding of the principles of large herbivore ecology and the African fossil record. We welcome this opportunity to correct certain misunderstandings, focusing here on the two most important issues. Our previous work shows that the richness of megaherbivores (>1,000 kg)…
Research by Cass Business School academics has presented a methodology for identifying how winter tourism operators can protect themselves against the risk of decreasing visitor numbers to ski destinations and lost revenues.
Patients taking warfarin to reduce the risk of stroke and pulmonary embolisms are often advised to take the medication in the evening. A new study shows evidence that morning versus evening dosing has insignificant bearing on how long the drug provides the most benefit for preventing adverse health events.
With a $2.3 million award from the National Institute for Occupational Safety and Health, an interdisciplinary team of Virginia Tech researchers led by Masoud Agah, the Virginia Microelectronics Consortium Professor in the Bradley Department of Electrical and Computer Engineering, is working to revolutionize a testing process for these harmful pollutants, in particular for truck drivers.
Red Flags Once again, scientists are calling for a moratorium on sex robots built to replace human relationships . Unless authorities impose strong regulations on the budding industry, experts told the BBC they can see a future where robots built to look like children or programmed to play the part of a rape victim could enable sexual violence against real-world victims. It's a disturbing image —
Genetic sequencing technologies are powerful tools that are used for the early detection and precise identification of pathogens; they have shown great improvement over the past 20 years. Using these novel technologies, scientists can identify pathogens down to their distinct DNA sequences, without the time- and labor-intensive need to grow pathogens in the lab.Scientists at Virginia Tech are taki
A team of physicists at the University of Sussex has successfully developed the first nonlinear camera capable of capturing high-resolution images of the interior of solid objects using terahertz (THz) radiation.
Researchers in Japan have identified a new quality control system that allows cells to remove damaged and potentially toxic proteins from their surroundings. The study, which will be published Feb. 18, 2020 in the Journal of Cell Biology, finds that the Clusterin protein and heparan sulfate proteoglycans combine to bring misfolded proteins into cells for degradation. The findings may lead to new t
After a week on a high fat, high added sugar diet, volunteers scored worse on memory tests Consuming a western diet for as little as one week can subtly impair brain function and encourage slim and otherwise healthy young people to overeat, scientists claim. Researchers found that after seven days on a high fat, high added sugar diet, volunteers in their 20s scored worse on memory tests and found
Controlling the properties of light is of great importance for many areas of physics, including imaging and nanolithography. But for short wavelengths, such as soft X-ray radiation, such control over the phase of light has remained elusive.
A Washington State University research team has developed a way to address a major safety issue with lithium metal batteries – an innovation that could make high-energy batteries more viable for next-generation energy storage.
Robert Stahelin studies some of the world's deadliest viruses. Filoviruses, including Ebola virus and Marburg virus, cause viral hemorrhagic fever with high fatality rates. Stahelin, professor at Purdue University, examines how these viruses take advantage of human host cells.
A world first review of the importance of nature play could transform children's play spaces, supporting investment in city and urban parks, while also delivering important opportunities for children's physical, social and emotional development.
Microbial communities associated with roots confer specific functions to their hosts, thereby modulating plant growth, health, and productivity. Yet, seminal questions remain largely unaddressed including whether and how the rhizosphere microbiome modulates root metabolism and exudation and, consequently, how plants fine tune this complex belowground web of interactions. Here we…
The SWR complex edits the histone composition of nucleosomes at promoters to facilitate transcription by replacing the two nucleosomal H2A-H2B (A-B) dimers with H2A.Z-H2B (Z-B) dimers. Swc5, a subunit of SWR, binds to A-B dimers, but its role in the histone replacement reaction was unclear. In this study, we showed…
In a recent study published in the journal eLIFE a team of researchers, including lead author Jordan Okie of Arizona State University's School of Earth and Space Exploration and senior author Jim Elser of the School of Life Sciences, conducted experiments in the Cuatro Cienegas Basin in Mexico. Their goal was to shed light on how fundamental features of an organism's genome – its size, the way it
Wiretapping GRU, Russia's foreign intelligence service, has reportedly dispatched agents to inspect the undersea internet cables that connect Europe and North America. These undersea fiber-optic cables are the crucial infrastructure between internet, phone, and other digital networks. And Russia's presence near cables in Ireland — a crucial hub — has Irish police concerned that GRU agents could t
Brazilian researchers found the level of uric acid in saliva to be a good indicator of body fat percentage in a study designed to identify reliable biomarkers that can be used to develop quick noninvasive tests for early detection of chronic diseases.
Two new commentaries on a contested 2018 study about gender disparities in STEM fields clash over whether sex differences or social inequalities are to blame for the lack of women scientists and engineers.
We must be able to trust the integrity of scientific research as we work to protect our families and our planet Not again. News out of Europe last week revealed that more than 20 scientific studies submitted to regulators to prove the safety of the popular weedkilling chemical glyphosate came from a large German laboratory that has been accused of fraud and other wrongdoing. The findings come ami
In 1900, German physician Paul Ehrlich came up with the notion of a "magic bullet." The basic idea is to inject a patient with smart particles capable of finding, recognizing, and treating a disease. Medicine has pursued the magic bullet ever since.
Like finding a needle in a haystack, Liviu Movileanu can find a single molecule in blood. Movileanu, professor at Syracuse University, and recently graduated Ph.D. student Avinash Thakur will present their research on Monday, February 17 at the 64th Annual Meeting of the Biophysical Society in San Diego, California. Their new technology has wide-ranging applications from diagnostic tests to drug d
The fossils found in Iraqi cave provide fresh evidence the species buried their death with mortuary rituals A Neanderthal skeleton unearthed in an Iraqi cave, already famous for fossils of these cousins of our species, is providing fresh evidence that they buried their dead – and intriguing clues that flowers may have been used in such rituals. Scientists said they had discovered the well-preserv
The accumulation of aberrant proteins in the body will cause various neurodegenerative diseases. Amyloid β is a known risk factor for Alzheimer's disease. The research team led by Eisuke Itakura, Chiba University, gained new knowledge of the functions that human cells have for maintaining homeostasis. The team discovered a system in which cells could capture, degrade and remove aberrant extracellu
In 1991, a devastating car crash left 32-year-old Munira Abdulla with severe brain injuries and in a deep coma. Doctors thought she had no chance of recovery. Yet her story blew up when, miraculously, her brain somehow "rebooted" nearly three decades later. Although disoriented, she was able to call out her son's name and engage in familiar prayer rituals. Munira's case is extraordinary. Regainin
The continuing epidemic of pre-term births includes this stark reality: tiny, fragile babies are born with underdeveloped lungs and prone to lifelong respiratory infections and related chronic illnesses. Researchers report new findings in Immunity that that will help in the development of new and cost effective methods to boost innate lung immunity in preterm babies.
A team of scientists using the Low Frequency Array radio telescope in the Netherlands has observed radio waves that carry the distinct signatures of aurorae, caused by the interaction between a star's magnetic field and a planet in orbit around it.
Crystal materials used in the solar-cell industry known as perovskites have been discovered to be cheap alternatives to shape laser light with potential application in industries as diverse as telecommunications, medical diagnostics and consumer electronics.
A recent study carried out by an international group of building scientists showed that Estonia is among the countries with the most energy efficient buildings in Europe. The analyses of the NZEB energy performance requirements and reference apartment buildings in four countries (Estonia, Norway, Finland and Sweden) showed that the nearly zero energy buildings constructed in Estonia are most energ
Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury remains an elusive goal. Using a mouse model of acute brain inflammation induced by local tumor necrosis factor alpha (TNFα), we found that uptake of intravenously injected antibody to vascular cell adhesion molecule 1 (anti-VCAM) in the…
Ten-eleven translocation (TET) family enzymes (TET1, TET2, and TET3) oxidize 5-methylcytosine (5mC) and generate 5-hydroxymethylcytosine (5hmC) marks on the genome. Each TET protein also interacts with specific binding partners and partly plays their role independent of catalytic activity. Although the basic role of TET enzymes is well established now, the…
Nature, Published online: 18 February 2020; doi:10.1038/d41586-020-00446-1 The conservation community must be able to track countries' progress in protecting wetlands, reefs, forests and more, argue James Watson and colleagues.
Intelligent Life Anthony Beasley, director of the US National Radio Astronomy Observatory in Charlottesville, Virginia, told the BBC that the search for extra-terrestrial intelligence (SETI) should be taken far more seriously, and given the governmental support and funding it deserves. His comments were made at the American Association for the Advancement of Science meeting in Seattle last week.
The number of horizontally drilled shale oil and gas wells in the United States has increased from nearly 28,000 in 2007 to nearly 127,000 in 2017, and research has suggested the potential for the development of shale resources to affect nearby stream ecosystems. However, the ability to generalize current studies…
Organisms use inorganic ions and macromolecules to regulate crystallization from amorphous precursors, endowing natural biominerals with complex morphologies and enhanced properties. The mechanisms by which modifiers enable these shape-preserving transformations are poorly understood. We used in situ liquid-phase transmission electron microscopy to follow the evolution from amorphous calcium carbo
The 1905 story about the Chicago meatpacking industry that inspired Upton Sinclair's novel The Jungle also shows the power of photojournalism, a study argues. The research looks back at a series of early 20th-century articles in The Lancet , which British scientists, sanitarians, and physicians were reading. Journalist Adolphe Smith wrote the articles, which offered a shocking look at Chicago's m
Smell loss leaves sufferers vulnerable to environmental hazards, such as spoiled food and gas leaks. (pathdoc/Shutterstock/) Carl Philpott is a professor of Rhinology and Olfactology at the University of East Anglia. This story originally featured on The Conversation . Losing your sense of smell or having it "disturbed" is not as rare as you might think: One in 20 people experience it at some poi
Despite the benefits of well-child care visits (WCV), up to half of WCVs are missed. A team of researchers and pediatricians at Virginia Commonwealth University, University of Washington, and the University of Vermont sought to understand the challenges that prevent families from attending their child's scheduled appointment.
UQ researchers have set a world record for the conversion of solar energy to electricity via the use of tiny nanoparticles called 'quantum dots'. The technology has a huge range of potential applications, including the possibility to use it as a flexible, transparent skin to power cars, planes, homes and wearable technology.
Aging, or senescence, is a progressive deterioration of physiological function with age. It leads to age-related declines in reproduction (reproductive senescence) and survival (actuarial senescence) in most organisms. However, senescence patterns can be highly variable across species, populations, and individuals, and the reasons for such variations remain poorly understood. Evolutionary…
SpaceX announced a new partnership Tuesday to send four tourists deeper into orbit than any private citizen before them, in a mission that could take place by 2022 and easily cost more than $100 million.
Space Tourism 2021 SpaceX announced a partnership this week with space tourism Space Adventures to start launching passengers to orbit aboard a Crew Dragon spacecraft starting as early as 2021, TechCrunch reports . SpaceX says it will send four privately-paying space tourists to orbit the Earth for five days in its Crew Dragon capsule between "late-2021 and mid-2022," according to CNBC . "This hi
SpaceX has been working toward a crewed NASA launch to the International Space Station (ISS) for years, but that's not the company's only plan for human spaceflight. Today, SpaceX and Space Adventures have announced a partnership that will bring Elon Musk's company fully into the world of space tourism. Within two years, SpaceX will send four civilians into orbit aboard its Dragon capsule . Space
Numerous fatty acid receptors have proven to play critical roles in normal physiology. Interactions among these receptor types and their subsequent membrane trafficking has not been fully elucidated, due in part to the lack of efficient tools to track these cellular events. In this study, we fabricated the surface-enhanced Raman…
Taking into account the effect of climatic changes over the last few millions of years on fauna both worldwide and in eastern Africa, hardly anyone would challenge the ecosystem shift addressed recently by Faith et al. (1). In eastern Africa, diminishing precipitation triggered the expansion of C4 grassland; reduced net…
The chaperone protein SmgGDS promotes cell-cycle progression and tumorigenesis in human breast and nonsmall cell lung cancer. Splice variants of SmgGDS, named SmgGDS-607 and SmgGDS-558, facilitate the activation of oncogenic members of the Ras and Rho families of small GTPases through membrane trafficking via regulation of the prenylation pathway. SmgGDS-607…
The emergence of superresolution (SR) fluorescence microscopy has rejuvenated the search for new cellular sub-structures and dynamic intermediates. However, limited by the broad emission spectrum of fluorophores and excessive phototoxicity, SR fluorescence microscopy can only be used to highlight a handful of biomolecules simultaneously and is incapable of providing a holistic map of the cellular
Scientists at the U.S. Department of Energy's Ames Laboratory have discovered that applying vibrational motion in a periodic manner may be the key to preventing dissipations of the desired electron states that would make advanced quantum computing and spintronics possible.
Unless you're Kylo Ren, you probably don't have an army of Stormtroopers to clean your lenses for you. So you might as well just learn how to do it yourself. (James Pond via Unsplash/) My grandmother always told me to wear clean underpants everyday in case I got hit by a car—and to keep my camera lens clean in case I needed to take a good photo. Granted, I made that last part up, but the fact tha
Tropomodulin maintains the fine balance between the protein machineries responsible for cell movement and morphogenesis. Disturbances in this balance are common in many diseases, for example, invasive cancers.
UCLA researchers have found that it is possible to assess a person's ability to feel empathy by studying their brain activity while they are resting rather than while they are engaged in specific tasks.
Investigators have been able to far more accurately determine rates of adverse events for people taking methotrexate, finding small-to-moderate elevations in risks for skin cancer, gastrointestinal, infectious, lung, and blood adverse events.
A team of researchers from Denmark, Australia and South Africa has found evidence that suggests stone-age etchings found at two sites in South Africa were created with aesthetic intention and that they evolved over time. In their paper published in Proceedings of the National Academy of Sciences, the group describes experiments they carried out with volunteers looking at reproductions of stone-age
Low oxygen levels in the heart have long been known to produce life-threatening arrhythmias, even sudden death. Until now, it was not clear how. New findings, in a study led by Steve A. N. Goldstein, MD, PhD, vice chancellor for Health Affairs at the University of California, Irvine, and distinguished professor in the UCI School of Medicine Departments of Pediatrics and Physiology & Biophysics, re
Exposing teeth to excessive fluoride alters calcium signaling, mitochondrial function, and gene expression in the cells forming tooth enamel — a novel explanation for how dental fluorosis, a condition caused by overexposure to fluoride during childhood, arises. The study, led by researchers at NYU College of Dentistry, is published in Science Signaling.
The origin of an understudied hybrid population of poisonous frogs—highly endangered colorful animals that live deep in the Colombian jungle—is the result of natural breeding and not caused by wildlife traffickers moving them, a University of Saskatchewan (USask) study shows.
A study published online as an accepted paper in the Journal of Clinical Sleep Medicine found that later school start times were associated with a significant drop in vehicle accidents involving teen drivers.
In a new study, researchers at University of California San Diego School of Medicine confirmed the findings of previous pilot studies that found an association between human milk concentrations and infant weight and body composition.
A new study by the University of Houston Institute for Research on Women, Gender & Sexuality (IRWGS) reports that women lag far behind men on multiple fronts in Harris County. Women are almost 50% more likely to live in poverty than men and the wage gap for men and women by race and ethnicity is considerably greater here than nationally. The report presents both new and summary analyses of select
New research from the Center for Cardiac Arrest Prevention at the Smidt Heart Institute at Cedars-Sinai shows that rates of sudden cardiac arrest are rising following decades of a downward trend. While this disturbing uptick was observed in both sexes, in women the increase was mostly among those whose sudden cardiac arrest was the first manifestation of heart disease. In men, the increase was mos
A strong majority of Americans agree that organ and tissue donation for research contributes to health and medical breakthroughs and acknowledge significant shortfalls for donation. This is according to a new survey released today commissioned by Research!America in partnership with The National Disease Research Interchange (NDRI).
A team of physicists at the University of Sussex has successfully developed the first nonlinear camera capable of capturing high-resolution images of the interior of solid objects using terahertz (THz) radiation.
Synaptotagmin 1 (Syt1) synchronizes neurotransmitter release to action potentials (APs) acting as the fast Ca2+ release sensor and as the inhibitor (clamp) of spontaneous and delayed asynchronous release. While the Syt1 Ca2+ activation mechanism has been well-characterized, how Syt1 clamps transmitter release remains enigmatic. Here we show that C2B domain-dependent…
In the cell, proteins are synthesized from N to C terminus and begin to fold during translation. Cotranslational folding mechanisms are therefore linked to elongation rate, which varies as a function of synonymous codon usage. However, synonymous codon substitutions can affect many distinct cellular processes, which has complicated attempts to…
Near-to-mid infrared colloidal quantum dots offer a promising platform towards the realization of many useful devices including emitters, detectors, security and sensor systems. Normally, physics imposes some fundamental limitations at longer wavelengths, and their performance decreases as the radiative emission rate of the quantum dots drops. Scientists from Hong Kong/China, Russia and Australia
A new technique can label diverse molecules and amplify the signal to help researchers spot those that are especially rare. Called SABER (signal amplification by exchange reaction), Peng Yin's lab at Harvard's Wyss Institute first introduced this method last year and since have found ways to apply it to proteins, DNA and RNA. Yin will explain how engineered DNA nanotechnology, including SABER, can
Teardown Japanese business newspaper Nikkei Asian Review recently conducted a teardown of a Tesla Model 3, and engineers were shocked at how advanced the electric car company's onboard computer technology was. "We cannot do it," an unnamed Japanese engineer at a rival car company said after analyzing the Model 3's integrated central control unit, as quoted by Nikkei — referring to legacy automake
Aggregation of α-synuclein is a defining molecular feature of Parkinson's disease, Lewy body dementia, and multiple systems atrophy. Hereditary mutations in α-synuclein are linked to both Parkinson's disease and Lewy body dementia; in particular, patients bearing the E46K disease mutation manifest a clinical picture of parkinsonism and Lewy body dementia,…