The Journal of Biological Chemistry (JBC) has retracted nine papers in bulk by a group of cancer researchers in New York led by the prominent scientist Andrew Dannenberg. The work of Dannenberg's group at Weill Cornell — and the figures in particular — has been the subject of scrutiny on PubPeer for more than two … Continue reading
The Worst Hey ladies, back me up: Isn't it just the worst when you go to charge your electric car and the cable is so darn heavy . Sometimes it feels like your dainty little lady arms are liable to just fall right off under the weight. That's the bizarre kind of conversation Ivan Espinosa, global product strategist for Japanese automaker Nissan , apparently believes female owners of the company's
Tobacco use remains the leading cause of preventable disease and death in the United States, killing more people each year than alcohol, AIDS, car accidents, illegal drugs, murder and suicide combined. Follow health policy expert Mitch Zeller into the murky depths of the tobacco industry as he details the sordid history of nicotine addiction — and invites us to imagine a world where policy change
These options can protect your eardrums from unnecessary damage. (Claire Benoist/) Standing too close to the speakers at a concert or heavy machinery at work can permanently damage your hearing. A solid set of plugs will protect your eardrums, but ensuring you have enough noise reduction is crucial. Consider these options—each blocks an increasing number of decibels—for everything from flying to
A new study led by Yale University researchers finds that scaling up use of methadone and buprenorphine could greatly reduce HIV transmission rates and prevent deaths in Ukraine.
Hermit crabs can teach us about wealth inequality, according to a new study. The distribution of the empty snail shells in which hermit crabs live was surprisingly similar to the distribution of wealth in human societies, the research finds. "Although people and hermit crabs are unlike in many ways, there is one big similarity: humans and hermit crabs both have possessions," says lead author Ivan
Big Picture Australia is in the midst of an environmental catastrophe, with raging wildfires making parts of the nation look like a blood-red apocalyptic hellscape. As dramatic as the scene on the ground might be, though, the view from above may be even more disturbing — as images of the wildfires taken from space show the full extent of the devastation. View from Above On Friday, Business Inside
The genome sequence of a water lily sheds light on the early evolution of angiosperms, the group of all flowering plants. Researchers used high-throughput next-generation sequencing technology to read out the water lily's ( Nymphaea colorata ) genome and transcriptome—the set of all genes expressed as RNAs. The unusual high quality and depth of coverage of the sequence allowed the researchers to
While resolutions are notorious for being abandoned not far into the new calendar year, really any time of year is a good time to refine the way you inhabit the world. When going through her midlife crisis at age 50, the writer Alison Gopnik said the philosopher David Hume's A T reatise of Human Nature— which argues that the beauty of life is the experience of living itself, without concern for t
Updated on Friday, January 3, 2019, at 3:37 p.m. ET. More so than any other president in the modern era, Donald Trump has made his administration a one-man spectacle. He hires and fires officials on impulse, demonstrating at every turn that the people under him are disposable and he's the only figure who counts. Should the conflict with Iran escalate into a hot war, Trump will be the one who need
People's skin can become inflamed when they wear cosmetics because a molecule in the skin triggers an immune response – but the reaction may be reversible
A 2017 report of the discovery of a particular kind of Majorana fermion–the chiral Majorana fermion, referred to as the 'angel particle'–is likely a false alarm, according to new research.
Freestanding clusters of twenty gold atoms take the shape of a pyramid, researchers discovered. This is in contrast with most elements, which organize themselves by forming shells around one central atom. The team of researchers led by KU Leuven published their findings in Science Advances.
Monash University researchers are on the brink of commercializing the world's most efficient lithium-sulfur (Li-S) battery, which could outperform current market leaders by more than four times, and power Australia and other global markets well into the future.
A new study shows that China's inland surface water quality improved significantly from 2003-2017, coinciding with major efforts beginning in 2001 to reduce water pollution in the country.
Researchers are closer to improved spinal fusion procedures and repairing broken or defective bones. In a preclinical study, researchers reduced undesired bone growth outside of targeted repair areas in rat femurs by delivering bone morphogenetic protein combined with a new biomaterial made from heparin.
Some compounds found in many personal care products displace natural fat-like molecules in skin cells, which may explain how they cause an allergic skin rash.
Investigators have uncovered a new molecular mechanism by which common components of consumer products can trigger an immune response, highlighting a specific molecular connection that may explain the mystery behind these cases of ACD.
In the last days of 2019, as millions of Americans were contemplating their resolutions for the year ahead, the moving-and-storage company U-Haul set one for all of its future employees. The company announced that starting February 1, it will stop hiring people who use nicotine in the 21 states where such a prohibition is legal, including Texas, Florida, and Massachusetts. Seventeen of those stat
Increased human activity threatens inland water quality in China. Major efforts have been made to alleviate water pollution since 2001. Understanding how water quality responds to these forces can help to guide future efforts to maintain water security and sustainability. We here analyzed the nationwide variability of inland water quality across China from 2003 to 2017 and its responses to anthro
Directional cell motility relies on the ability of single cells to establish a front-rear polarity and can occur in the absence of external cues. The initiation of migration has often been attributed to the spontaneous polarization of cytoskeleton components, while the spatiotemporal evolution of cell-substrate interaction forces has yet to be resolved. Here, we establish a one-dimensional microf
Surface-emitting semiconductor lasers have been widely used in data communications, sensing, and recently in Face ID and augmented reality glasses. Here, we report the first achievement of an all-epitaxial, distributed Bragg reflector (DBR)–free electrically injected surface-emitting green laser by exploiting the photonic band edge modes formed in dislocation-free gallium nitride nanocrystal arra
The social bond between parents and offspring is characterized by coadaptation and balance between altruistic and selfish tendencies. However, its underlying genetic mechanism remains poorly understood. Using transcriptomic screens in the subsocial European earwig, Forficula auricularia , we found the expression of more than 1600 genes associated with experimentally manipulated parenting. We iden
P-rich transition metal phosphides (TMPs) with abundant P sites have been predicted to be more favorable for hydrogen evolution reaction (HER) catalysis. However, the actual activities of P-rich TMPs do not behave as expected, and the underlying essence especially at the atomic level is also ambiguous. Our structural analysis reveals the inferior activity could stem from the reduced overlap of at
Earlier vegetation greening under climate change raises evapotranspiration and thus lowers spring soil moisture, yet the extent and magnitude of this water deficit persistence into the following summer remain elusive. We provide observational evidence that increased foliage cover over the Northern Hemisphere, during 1982–2011, triggers an additional soil moisture deficit that is further carried o
Metabolic syndrome (MetS) is intricately linked to dysregulation of gut microbiota and host metabolomes. Here, we first find that a purified citrus polymethoxyflavone-rich extract (PMFE) potently ameliorates high-fat diet (HFD)–induced MetS, alleviates gut dysbiosis, and regulates branched-chain amino acid (BCAA) metabolism using 16 S rDNA amplicon sequencing and metabolomic profiling. The metabo
At least some of Venus' lava flows are thought to be 2 O 3 ). With increasing alteration, the VNIR 1000-nm absorption, characteristic of olivine, also weakens within days. Our results indicate that lava flows lacking VNIR features due to hematite are no more than several years old. Therefore, Venus is volcanically active now.
Generating optimal nanomaterials using artificial neural networks can potentially lead to a notable revolution in future materials design. Although progress has been made in creating small and simple molecules, complex materials such as crystalline porous materials have yet to be generated using any of the neural networks. Here, we have implemented a generative adversarial network that uses a tra
Development of renewable energy is essential to mitigating the fossil fuel shortage and climate change issues. Here, we propose to produce a new type of energy, bio-coal, via a fast pyrolysis coupled with atmospheric distillation process. The high heating values of the as-prepared bio-coals from the representative biomass are within 25.4 to 28.2 MJ kg –1 , which are comparable to that of the comm
Supraphysiologic doses of bone morphogenetic protein-2 (BMP-2) are used clinically to promote bone formation in fracture nonunions, large bone defects, and spinal fusion. However, abnormal bone formation (i.e., heterotopic ossification) caused by rapid BMP-2 release from conventional collagen sponge scaffolds is a serious complication. We leveraged the strong affinity interactions between heparin
Lithium-sulfur batteries can displace lithium-ion by delivering higher specific energy. Presently, however, the superior energy performance fades rapidly when the sulfur electrode is loaded to the required levels—5 to 10 mg cm –2 — due to substantial volume change of lithiation/delithiation and the resultant stresses. Inspired by the classical approaches in particle agglomeration theories, we fou
The free-standing Au 20 cluster has a unique tetrahedral shape and a large HOMO-LUMO (highest occupied molecular orbital–lowest unoccupied molecular orbital) gap of around 1.8 electron volts. The "magic" Au 20 has been intensively used as a model system for understanding the catalytic and optical properties of gold nanoclusters. However, direct real-space ground-state characterization at the atom
A new study shows that China's inland surface water quality improved significantly from 2003-2017, coinciding with major efforts beginning in 2001 to reduce water pollution in the country.
For the past two years, software engineers and systems administrators from San Jose to Seattle have engaged in the tech industry's latest rite of passage: reading the news to discover that their employer contributed to something they find unethical. In 2018, Google workers learned of the company's secret U.S. military contract and state-censorship search project in China from media reports. In Fe
Déja Vu It seems life really does imitate art — for better or worse. On Friday, Segway-Ninebot announced several new transportation products it plans to unveil at next week's Consumer Electronics Show — and as pointed out by Wired , one of them looks eerily similar to the hover chairs featured in the post-apocalyptic Pixar film "WALL-E." Segway S-Pod The device is called the Segway S-Pod, and lik
Go worry-free on your next vacation. (Ferran Feixas via Unsplash/) Money belts are a must for traveling; they keep your important documents, money, and cards safe, secure, and in order. Take advantage of the certainty these products bring beyond travel, from outdoor exercise to nights on the town. Depending on where you're going and what you're carrying, you'll want to factor in size, how easy th
"The words of the Torah should be burned rather than entrusted to women." This is the stinging opinion of Rabbi Eliezer ben Hyrcanus, a second-century Jewish scholar, as expressed in the Talmud, a 63-volume work of intricate Jewish legal debates, composed from the second to sixth centuries and redacted in Babylonia. Only a few women are mentioned in its 2,711 pages. The very same sage elsewhere s
The amount of ice in the Earth's rivers has declined rapidly over the past three decades, and the trend is likely to continue, researches report. Rivers that seasonably freeze over drain more than a third of the Earth's land mass. Examining more than 400,000 satellite images over the past 34 years, researchers found that the overall amount of river ice has declined, and will almost certainly cont
Ultra-compact, yet high-performing electronic chips could overcome the challenges that face conventional integrated circuits and maintain Moore's Law indefinitely, researchers say. To create the chips, researchers would take advantage of relatively new and promising two-dimensional (2D) materials and combining them with monolithic 3D (M3D) integration practices. Moore's Law says that the number o
Cosmic gunk expelled from a dying star like this one in the Aquarius constellation might be able to congeal into a comet. (NASA/JPL-Caltech/) Just about every clump of ice, rock or gas in our solar system, from Halley's comet to Earth to Jupiter, formed the same way: from a swirling cloud of dust and gas left over after the birth of the sun. So when astronomers spotted an unknown object coming sc
Mathematicians are devising new techniques to better predict how to tie strong knots that are useful in climbing and sailing — Read more on ScientificAmerican.com
Mathematicians are devising new techniques to better predict how to tie strong knots that are useful in climbing and sailing — Read more on ScientificAmerican.com
A new study by San Francisco State University Assistant Professor of Management Nara Jeong suggests that CEOs look to the White House for leadership on social responsibility—but not the way you might expect. It turns out that corporate leaders are less likely to act on their values when they're in agreement with the president. And their social responsibility efforts increase when they don't agree
A president's political party plays a big role in corporate social responsibility efforts, reveals new research from San Francisco State's Lam Family College of Business.
A senior adviser to the UK's prime minister suggests policy-making can be improved by training AI on government data, but the researchers he cites say they aren't so sure
A team of scientists at the Harvard T.H. Chan School of Public Health found traces of two microbial toxins, endotoxin and glucan, in vaping company Juul's nicotine vaping pods. Endotoxin is a microbial agent and a component of the exterior cell wall of certain types of bacteria, including E. coli. Luckily, endotoxin levels were found to be below the limit of detection in Juul's pods according to
There was a case for killing Major General Qassem Soleimani. For two decades, as the commander of the Revolutionary Guards' Quds Force, he executed Iran's long game of strategic depth in the Middle East—arming and guiding proxy militias in Lebanon and Iraq that became stronger than either state, giving Bashar al-Assad essential support to win the Syrian civil war at the cost of half a million liv
In 2006, more than 400 children under the age of 5 died during an outbreak of diarrheal disease in Botswana. In what was a 25-fold increase in diarrheal disease mortality for this age group, citizens of the country were devastated.
In 2006, more than 400 children under the age of 5 died during an outbreak of diarrheal disease in Botswana. In what was a 25-fold increase in diarrheal disease mortality for this age group, citizens of the country were devastated.
The environmental fate of microplastics has been difficult to trace. A research group led by the University of Jyväskylä used carbon isotope labeling to follow the fate of polyethylene in the food chain. For the surprise of the researchers, plastic carbon was transformed even to beneficial fatty acids, omega-3 and omega-6, by the microbes originating from humic lakes. The research was published in
On Thursday, organizers announced the 2020 lineup for arguably the most-hyped music festival in the world: Coachella. As rumored, Rage Against the Machine, Frank Ocean, and Travis Scott are set to headline the April event — but sharing the stage with some of the biggest artists alive today will be one who isn't alive at all: virtual pop star Hatsune Miku. Miku is a blue-haired, computer-generated
The year is just beginning. You've got this. (Li Zhongfei via Deposit Photos/) When it comes to trying to improve your life and well-being in 2020, know that you're not alone—help is on hand from your friends, your family, and yes, even your smartphone. No matter what your aims are, tap on your app store and give yourself a better chance of becoming part of that 20 percent that actually succeeds
Nature, Published online: 03 January 2020; doi:10.1038/d41586-019-03930-5 The explosive outburst in what is now Peru was much bigger than scientists had realized.
Engineers have developed a mineral-coated sand that can soak up toxic metals like lead and cadmium from water. Along with its ability to destroy organic pollutants like bisphenol A, this material could help cities tap into stormwater, an abundant but underused water source. Researchers knew that the naturally occurring minerals they coated onto sand could react with organic contaminants like pest
Could bile acids — the fat-dissolving juices churned out by the liver and gallbladder — also play a role in immunity and inflammation?The answer appears to be yes, according to two separate Harvard Medical School studies published in Nature.
Kathy Alexander, a professor of fish and wildlife conservation in the College of Natural Resources and Environment at Virginia Tech discovered an astonishing and robust link between environmental change and environmental dynamics, which ties human health to the health of the ecosystem. With this knowledge, researchers will be able to predict when diarrheal disease will reoccur.
Television programs featuring healthy foods can be a key ingredient in leading children to make healthier food choices now and into adulthood. A new study in the Journal of Nutrition Education and Behavior, published by Elsevier, found kids who watched a child-oriented cooking show featuring healthy food were 2.7 times more likely to make a healthy food choice than those who watched a different ep
Columbia professors offer their perspective on a recent study on Pyrethroid, among the most widely used insecticides for public health control of vector-borne illnesses, including West Nile virus. While the insecticides are generally regarded as posing low health risks to humans in ordinary exposure situations, results show a 50 percent increase in total mortality and three-fold increase in heart
Moon Energy Billions of years ago, scientists believe that the Moon had a magnetic field, much like Earth's. But that field shut down at some point — and a team of MIT scientists now say it was because of a crystallizing iron core that shut down an ancient "dynamo" inside the natural satellite about a billion years ago. One Billion Years "The magnetic field is this nebulous thing that pervades sp
Where the best conversations happen. ( Sanjeev Grover via Unsplash/) Nothing makes a camping trip or a night out in the backyard more enjoyable than a meal and conversation enjoyed around a fire. Fire-gazing was even once a form of flame-based reverie, in which one stared into the amorphous nature of jumping flames and saw arbitrary images. Get yourself a fire pit, give yourself a break from star
Communication and marketing experts place great weight on an organization's relationship with its public stakeholders, and a new tool allows organizations to better measure and describe the nature of these relationships.
Both humans and chimpanzees can be extremely territorial, and territorial disputes between groups can turn violent, with individuals killing each other. In humans, such between-group competition can escalate to war and devastating loss of human life. Researchers from the Max Planck Institute for Evolutionary Anthropology studied wild Western chimpanzees to find out whether territorial behavior may
Both humans and chimpanzees can be extremely territorial, and territorial disputes between groups can turn violent, with individuals killing each other. In humans, such between-group competition can escalate to war and devastating loss of human life. Researchers from the Max Planck Institute for Evolutionary Anthropology studied wild Western chimpanzees to find out whether territorial behavior may
A first-of-its-kind study on molecular interactions by biomedical engineers in the University of Minnesota's College of Science and Engineering will make it easier and more efficient for scientists to develop new medicines and other therapies for diseases such as cancer, HIV and autoimmune diseases.
A more comprehensive measure of innovation suggests it isn't exclusive to big cities. The "hidden" innovation of rural areas brings economic benefits to businesses and communities, according to researchers, whose findings will help decision makers think in new ways about innovation and how they can support it. "The way we traditionally measure innovation is very narrow, and focuses primarily on n
Upgrade your sound. (Amazon/) We can create exceptionally clear recordings in surround sound with incredible special effects—but we often listen to media through compressed streaming files on tiny devices, with even tinier speakers. Sound bars are a great middle ground to appreciate everything your TV has to offer without turning your living room into a multi-channel speaker showroom. These super
A first-of-its-kind study on molecular interactions by biomedical engineers in the University of Minnesota's College of Science and Engineering will make it easier and more efficient for scientists to develop new medicines and other therapies for diseases such as cancer, HIV and autoimmune diseases.
The charges for air ambulance services in 2016 hovered between 4.1 and 9.5 times the rate Medicare allows, a new study shows. Publicly insured and in-network patients generally escaped paying full cost, but uninsured and out-of-network patients likely received bills for the whole amount. For-profit companies primarily run air ambulance services in the US—and charges usually consist of an initial
A study of 3700 people suggests that exposure to air pollution is linked to lower bone mineral content. This may make people more likely to develop osteoporosis
What T-rex looked like during its teen years—whether it was a mini version of its adult self or distinctively shaped—has been an ongoing controversy in the paleontology world. There's a reason that Tyrannosaurus rex has earned its reputation as the king of dinosaurs. Its massive size and powerful, bone-crunching jaws made T-rex a force to reckon with (or, more likely, flee from). But the species
How can we tap into the potential of all students, especially those who come from disadvantaged backgrounds? Sociologist Anindya Kundu invites us to take a deeper look at the personal, social and institutional challenges that keep students from thriving in the United States — and shows how closing this "opportunity gap" means valuing public education for what it really is: the greatest investment
A new tool allows organizations to better measure and describe the nature of an organization's relationship with its public stakeholders to inform public relations and marketing. "Traditionally, these relationships are measured using questionnaires, which provide only a static snapshot of how one party viewed an organization," says coauthor Yang Cheng, an assistant professor of communication at N
A first-of-its-kind study on molecular interactions by biomedical engineers in the University of Minnesota's College of Science and Engineering will make it easier and more efficient for scientists to develop new medicines and other therapies for diseases such as cancer, HIV, and autoimmune diseases.
During a long-term mission aboard the International Space Station, a NASA astronaut developed a blood clot in their jugular vein, the space agency has revealed. With the closest emergency room a Soyuz rocket ride away, NASA had to call up an expert. "When the astronaut called my home phone, my wife answered and then passed the phone to me with the comment, 'Stephan, a phone call for you from spac
A recently published study indicates that oral infections seem to have no association with the risk of stem cell transplantation patients dying of or getting a serious infection within six months of the procedure.
Penn researchers applied tools from network science to identify how anatomical connections in the brain develop to support neural activity underlying executive function.
Territorial conflicts can turn violent in humans and chimpanzees, two extremely territorial species. An international team of researchers from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, has studied the effects of territoriality on female reproductive success in wild Western chimpanzees and found that high neighbor pressure at times when females typically reproduce
Communication and marketing experts place great weight on an organization's relationship with its public stakeholders, and a new tool allows organizations to better measure and describe the nature of these relationships.
In a newly published series appearing in Environmental Toxicology and Chemistry, researchers describe the current state of the science, the challenges, and science-based best practices for modeling the influence of water chemistry on the toxicity of metals, which is a critical step in calculating protective metal concentrations in water for the protection of aquatic life.
A new expert review confirms that diet significantly influences mental health and wellbeing, but cautions that the evidence for many diets is comparatively weak. This, the most up to date overview of the new field of Nutritional Psychiatry, is produced, by the Nutrition Network of the ECNP and is published in the peer-reviewed journal European Neuropsychopharmacology.
Take a load off. (Nik MacMillan via Unsplash/) Laundry is the chore that never ends. You've probably done it so many times that you don't even think about it anymore—and it's easy to miss the little tweaks that can save time, money, and your back. Here are a few products that fix common problems and make a dreary chore just a bit more bearable. Put these cuties to work. (Amazon/) Keep wet clothes
Dependable without being bulky. (Bench Accounting via Unsplash/) With the rise of freelancing, side hustles, and streaming entertainment, having a good laptop is essential to both work and play. When your smartphone's screen size and iPad's app choice just don't cut it, a zippy laptop with a lot of storage and minimal bulk is ideal. These four excellent options offer the best hardware and softwar
Why did we take so long to invent civilization? Modern Homo sapiens first evolved roughly 250,000 to 350,000 years ago. But initial steps towards civilization—harvesting, then domestication of crop plants—began only around 10,000 years ago, with the first civilizations appearing 6,400 years ago.
A protester hits a poster of Qassem Soleimani during anti-government protests in Baghdad in November 2019. (Associated Press) BEIRUT—As soon as Qassem Soleimani, the leader of the Quds Force of Iran's Islamic Revolutionary Guard Corps, was confirmed dead, lawyers and lawmakers in Washington began their debates. Was the strike that killed him legal? How would the attack play into the political cyc
Tipping Point On Tuesday, the Duke and Duchess of Cambridge announced the Earthshot Prize , an initiative designed to solve Earth's greatest environmental problems before 2030. "The earth is at a tipping point," Prince William said in a statement , "and we face a stark choice: either we continue as we are and irreparably damage our planet or we remember our unique power as human beings and our co
For many couples, moving in together signifies a big step in the relationship. Traditionally, this meant marriage, although nowadays most cohabit before getting married, or splitting up. But there is a third choice: living apart together.
As we enter our third decade in the 21st century, it seems appropriate to reflect on the ways technology developed and note the breakthroughs that were achieved in the last 10 years. The 2010s saw IBM's Watson win a game of Jeopardy, ushering in mainstream awareness of machine learning, along with DeepMind's AlphaGO becoming the world's Go champion. It was the decade that industrial tools like dr
Researchers have reversed electrons' course in the reaction center of photosynthetic bacteria—advancing understanding of the earliest light-driven events of photosynthesis. Photosynthetic organisms have a switch point that's similar to a split in train tracks where a train always goes right. After sunlight is absorbed, energy transfers rapidly to a protein called the reaction center. From this po
Here researchers report an efficient non-HR-based method for generating zebrafish carrying a CKO and knockin (KI) switch (zCKOIS) coupled with dual-color fluorescent reporters. Using this strategy, they generated hey2zCKOIS which served as a hey2 KI reporter with EGFP expression. Upon Cre induction in targeted cells, the hey2zCKOIS was switched to a non-functional CKO allele hey2zCKOIS-inv associa
The research was supported by a Russian Science Foundation's grant under the title 'Synthesis and research of a new class of nanocomposite ceramics with degenerate dielectric permeability for opto-plasmonic applications.'
Researchers from the University of Maryland School of Medicine and their colleagues have identified the structure of the most lethal toxin produced by certain strains of Clostridium difficile bacteria, a potentially deadly infection associated with the use of antibiotics. The researchers mapped out the delivery and binding components of the toxin, which could pave the way for new drugs to neutrali
Iron dust may have played a significant role in the last ice age, and it could be an important factor in mitigating future global temperature increases
Kaci Alvarez, a 20-year-old journalism student living in Ontario, Canada, used to watch YouTube videos before going to bed. Her ears ring, and she found that the sounds of some online videos, especially the voice of a YouTuber named Ryan Klepacs, relieved the din. Two years ago, after Alvarez tuned into a live video Q&A that Klepacs hosted for fans, the two met, and they quickly started dating de
Near-record Arctic melting, a bountiful but deadly monsoon and three highly destructive tropical cyclones highlight the earth's second warmest year on record — Read more on ScientificAmerican.com
Product labels offer valuable information to consumers, but manufacturers can misuse them to increase profits. This is particularly true for the U.S. Department of Agriculture's organic label.
Using the Southern African Large Telescope (SALT), astronomers have conducted spectroscopic and imaging observations of the planetary nebula WR 72. They discovered hydrogen-poor knots in the central part of the nebula, which could be helpful in improving knowledge about the nature of this object. The finding is detailed in a paper published December 23 on arXiv.org.
In a study published in Environment International researchers from King's have, for the first time, measured ultrafine particles (UFP) in European cities and detected emissions from airports.
A look at the dynamics of essential proteins that help DNA fold into its compact, functional form in chromosomes reveals that a key protein's "coiled coils" braid around each other and writhe like snakes as they form bigger loops in the DNA. The loops, in turn, bring together sites on DNA that regulate the transcription of genetic messages. While the loops and their functions are becoming better
Scientists at the University of Maryland (UMD) and the National Institute of Standards and Technology (NIST) have discovered a way to detect the molecular mechanism by which 5HT3A, a serotonin receptor located at the neuron synapse, is activated. Having a molecular model of this activation will allow the testing of pharmaceuticals inhibitors using computer models instead of traditional experiments
As the New Year starts, the outlook for the bushfire situation in Australia continues to be grim. These huge and disastrous fires continue to burn ferociously and with abandon, and reports have come out that the fires have actually intensified in the last 12 hours. NOAA-NASA's Suomi NPP satellite captured imagery of the fires and the resultant billowing smoke cascading off the edge of Australia on
Scientists at the University of Maryland (UMD) and the National Institute of Standards and Technology (NIST) have discovered a way to detect the molecular mechanism by which 5HT3A, a serotonin receptor located at the neuron synapse, is activated. Having a molecular model of this activation will allow the testing of pharmaceuticals inhibitors using computer models instead of traditional experiments
For Ants Particle accelerators are usually large. The Large Hadron Collider, for instance, is 17 miles in circumference. But now a team of scientists at Stanford have created a silicon chip that can act as a particle accelerator — and it's only 30 micrometers long, about the width of a human hair. Smallville On the most basic level, particle accelerators are machines that speed up beams of charge
People in predominantly Hispanic neighborhoods are less likely to receive CPR from a bystander, a new study shows. The findings confirm that the ethnic makeup of the neighborhood where a person experiences sudden cardiac arrest has a lot to do with whether they will survive the event, researchers say. "Identifying these disparities highlights an important public health problem and leads us to thi
Word came out yesterday from Frances Arnold of Caltech (via her Twitter account ) that she and her co-authors are retracting this paper from Science . The retraction notice itself has the details: After publication of the Report "Site-selective enzymatic C‒H amidation for synthesis of diverse lactams" ( 1 ), efforts to reproduce the work showed that the enzymes do not catalyze the reactions with
Families of children with autism face high physical, mental, and emotional burdens, are sometimes face ridicule and accusations of child abuse, according to a new small study. The study surveyed 25 caregivers of 16 children ages 2 to 20 with autism spectrum disorder to evaluate how their care affected their family dynamics, physical and mental health, and social functioning. The researchers also
Authorities in western Poland say they have ordered the culling of at least 65,000 hen at a farm affected by bird flu that seems to have spread from the east.
Authorities in western Poland say they have ordered the culling of at least 65,000 hen at a farm affected by bird flu that seems to have spread from the east.
An F-15C on an unrelated flight in Nevada in November, 2019. (US Air Force / Airman 1st Class Bryan Guthrie/) In late March of 2019, in a military operating area over Oregon, a student pilot and an instructor were conducting a two-aircraft training mission on basic fighter maneuvers. Each aviator was in their own F-15C jet. It was early afternoon, and the aircraft were at about 18,000 feet. The s
In today's climate change narrative, animal-based agriculture often endures criticism for its alleged contributions to the global problem. With some naysayers ranking the industry second only to the population explosion as a root contributor to global warming and other weather-related devastation, the concern for how food is—and can be—produced has become even more pressing.
The next wave of robots to fly to Mars in 2020 could offer scientists an unprecedented understanding of Earth's closest neighboring planet. But there are still mysteries to be solved much closer to home, on Earth's own moon.
In Australia, interment in a cemetery or a churchyard has been the most common choices for in-ground burial. Over the past 20 years, though, burial has become a less accessible and more costly option for many people. This is because increasing numbers of deaths have created a boom in demand for burial plots and cemeteries are fast running out of space.
The end of the year and the dawning of a new one can be a great time to examine happiness and well-being. That quest for meaning will often turn its attention to the workplace.
Smarte højttalere, som er mere end ti år gamle, vil ikke levere den oplevelse, som vores kunder forventer. Sådan begrunder Sonos, hvorfor nogle af modellerne bliver gjort ubrugelige, når kunderne køber nye.
Illuminate your life. (Anshu A via Unsplash/) Few things can brighten the mood of a home, yard, or office like a string of old-fashioned twinkle lights. There's a reason they're popular for the holidays, but there are no rules against keeping these warm and cozy accent bulbs up all year round. If you've got a dark corner in your living room, or your windows are looking bland, or maybe you want to
Watching fireworks on television is nothing like watching them in real life. Televised fireworks aren't very attractive compared with the experience of watching them live, with dull colors and muted explosions. Best-case, they look flat and uninspiring. Worst-case, they can look like badly rendered CGI. A recent Wired UK article dives into why fireworks are so hard to get right, even on modern te
Since the beginning of time, music has been a way of communicating observations of and experiences about the world. For Indigenous Peoples who have lived within their traditional territories for generations, music is a repository of ecological knowledge, with songs embedding ancestors' knowledge, teachings and wisdom.
Global warming is driving rapid environmental change in the Arctic. "To understand these changes, field measurements that adequately represent environmental variation across the Arctic as a whole are crucial," says Ph.D. student Anna-Maria Virkkala from the University of Helsinki.
Climate change skeptics may be a minority, but they are a sizable one. One in five Americans think that climate change is a myth, or that humans aren't responsible for it. What's more, they're backed up by many in the Middle East and parts of Asia, especially China. They're a vocal minority too—and with the ear of the US president, they are therefore a serious obstacle to collective climate action
A stack of pancakes ladened with syrup, a frothy latte posed next to a white MacBook, a deep pan pizza oozing with cheese. Instagram has made "food porn"—images that portray food in an appetizing or aesthetically appealing way—commonplace. Food is now the most photographed subject on the platform, and #food, #foodporn, #instafood and #yummy are all among the most popular hashtags.
A novel immunotherapy treatment has saved family dog Griffin from a rare type of cancer, thanks to collaborative research at The University of Queensland.
A novel immunotherapy treatment has saved family dog Griffin from a rare type of cancer, thanks to collaborative research at The University of Queensland.
If we discovered evidence of alien life, would we even realize it? Life on other planets could be so different from what we're used to that we might not recognize any biological signatures that it produces.
A team of researchers with members from Singapore, the U.S., Thailand and Laos has concluded that the impact point of a meteorite that struck the Earth approximately 790,000 years ago lies buried beneath a volcanic field in southern Laos. In their paper published in Proceedings of the National Academy of Sciences, the group outlines four lines of evidence that point to the Bolaven volcanic field a
Three decades ago, the world was home to fewer than a dozen border walls. Now, their numbers have swelled to more than 50. In a supposed era of openness and collaboration, why are these structures not only persisting, but proliferating?
Germany's new Waste and Sewage Sludge Ordinance requires large sewage treatment plants to recover phosphates from sewage sludge or ashes as of 2032. Conventional recovery technologies are costly and chemical-laden. A new technology now offers a more affordable, pollution-free alternative. Fraunhofer researchers helped scale up the process.
Resistance to antibiotics is on the rise worldwide. Fraunhofer scientists have joined forces with partners in the Phage4Cure project to explore alternatives to antibiotics. One objective is to vanquish multidrug-resistant pathogens with viruses called bacteriophages. Another is to see these phages approved to treat the dreaded hospital germ Pseudomonas aeruginosa, the most frequent bacterial cause
Northeastern researchers have used a powerful computer model to probe a puzzling class of copper-based materials that can be turned into superconductors. Their findings offer tantalizing clues for a decades-old mystery, and a step forward for quantum computing.
Yes, but only if we do it in targeted ways that are attentive to the needs of babies, families and health systems — Read more on ScientificAmerican.com
Resistance to antibiotics is on the rise worldwide. Fraunhofer scientists have joined forces with partners in the Phage4Cure project to explore alternatives to antibiotics. One objective is to vanquish multidrug-resistant pathogens with viruses called bacteriophages. Another is to see these phages approved to treat the dreaded hospital germ Pseudomonas aeruginosa, the most frequent bacterial cause
A new augmented reality game system called iGYM aims to create a truly inclusive environment for kids with and without disabilities to play and exercise together. While adaptive sports like powerchair football provide invaluable opportunities for children with mobility disabilities to participate in athletic events, these games are not designed for competitive play between kids with disabilities
Hollywood has long excelled at mining beauty from war . Some of moviemaking's most indelible images have come from dramatizations of battle, from the early Oscar winner All Quiet on the Western Front to Christopher Nolan's 2017 blockbuster, Dunkirk . Taking any situation, such as the horrifying trench combat of the First World War, and turning it into cinema will smooth away some of the crueler r
The Trillion Tree campaign aims to buy us 20 years time by sequestering carbon in 1 trillion new trees, by generating and reforesting massive tracts of land which is now used for grazing and grasslands. However, as the fires in Australia shows, those dense forests would be incredibly vulnerable to fire contagion, especially as the climate dries. So, do massive forest fires make the Trillion Tree
Nature, Published online: 03 January 2020; doi:10.1038/d41586-020-00001-y Chinese court sends strong signal by punishing He Jiankui and two colleagues.
The Gadget Lab crew discusses what they expect to see next week in Las Vegas: facial-recognition tech, 5G everywhere, and self-driving scooters galore.
This is a quick follow up in the golden rice story (golden rice is a GM rice with added beta carotene, a precursor to vitamin A). I have written about it here , here , and most recently here . The news is that the Philippines have just approved golden rice as safe for human and animal consumption. The US, Canada, Australia and New Zealand have already approved golden rice, but these approvals wer
Researchers found that people who spend more time outdoors also spend more time being active and socializing, but it probably doesn't account for all of the health boost associated with green spaces.
Yes, but only if we do it in targeted ways that are attentive to the needs of babies, families and health systems — Read more on ScientificAmerican.com
Forskere fra KTH i Sverige har omregnet vores samlede energiforbrug per person til madkalorier for at se, hvor store vi ville være, hvis vi spiste hele forbruget. Svaret er: 12 meter høje.
Qassem Soleimani, the commander of the Islamic Revolutionary Guards Corps's Quds Force who was killed in Iraq yesterday, was the most successful military figure of his time. One should grade success not in absolute terms, but by how much is done with how little — and on that scale, Soleimani was a prodigy. The end of his career is as pivotal in the region as the retirement of an athlete who has d
Sand in the oil stream with the risk of well collapse is a well-known problem when sandstone reservoirs approach depletion. Advanced sensors and a super machine are helping research scientists to find the threshold at which profitable production ceases. This can increase the lifetime of reservoirs.
The bushfires raging across Australia have had a devastating impact on the country's unique flora and fauna, with some estimates putting the death toll at nearly half a billion animals in one state alone, and experts believe it could take decades for wildlife to recover.
When a hot plume of rock rises through the Earth's mantle to puncture the overlying crust, it can create not only a volcanic ocean island, but also a swell in the ocean floor hundreds to thousands of kilometers long. Over time the island is carried away by the underlying tectonic plate, and the plume pops out another island in its place. Over millions of years, this geological hotspot can produce
In sailing, rock climbing, construction, and any activity requiring the securing of ropes, certain knots are known to be stronger than others. Any seasoned sailor knows, for instance, that one type of knot will secure a sheet to a headsail, while another is better for hitching a boat to a piling.
The 100 highest-paid CEOs in Canada made 227 times more than the average worker in 2018, an unprecedented high, according to a report published Thursday.
Beleaguered Australian communities braced for yet more catastrophic bushfire conditions expected on Saturday, as Australia's navy evacuated around one thousand people from a southeastern town.
Using the High-Resolution Echelle Spectrometer (HIRES), astronomers from Georgia State University (GSU) in Atlanta have investigated the nature of young stars near the cometary globule CG 30. The new study, presented December 20 on arXiv.org, provides important information about the properties of 21 young stars in this area.
Scientists at the Laboratory for Attosecond Physics have developed a unique laser technology for the analysis of the molecular composition of biological samples. It is capable of detecting minimal variations in the chemical make up of organic systems.
Treatment could clear up persistent infections and reduce risk of cervical cancer The broadest vaccine yet that could clear up persistent HPV infections and reduce the risk of women developing cervical cancer is to be tested in a clinical trial. Human papillomavirus infections are common and are generally cleared by the body. However, about 10% of infections are not cleared, with persistent infec
In October this year, weather researchers in Utah measured the lowest temperature ever recorded in the month of October in the U.S. (excluding Alaska): -37.1 degrees C. The previous low-temperature record for October was -35 degrees C, and people wondered about the relationship to climate change.
The thermoelectric conversion efficiency of a particular material is determined by the value of its thermoelectric figure of merit zT. It is a complex function of the absolute temperature and several pertinent transport properties including the Seebeck coefficient, the electrical and thermal conductivities. These quantities are usually measured in parallel to each other, reflecting the longitudina
In business, the role of a leader is often misunderstood. A true leader takes care of their people, especially when considering new hires. Leaders should take hiring decisions as seriously as adoption. Protecting the culture you've cultivated is more important than acquiring skills.
The Atlantic Multidecadal Oscillation (AMO) and the Pacific Decadal Oscillation (PDO) do not appear to exist, according to a team of meteorologists who believe this has implications for both the validity of previous studies attributing past trends to these hypothetical natural oscillations and for the prospects of decade-scale climate predictability.
Tyske forskere har formået at fremstille en gruppe immunceller, som binder sig til en række faste tumorer. Tilføjelse af en RNA-vaccine giver cellerne ekstra kræfter.
Three researchers from the University of Oxford and the South Iceland Nature Research Centre have found evidence of tool use by puffins—the first evidence of tool use by any seabird. In their paper published in Proceedings of the National Academy of Sciences, Annette Fayet, Erpur Snær Hansen and Dora Biro describe their evidence of puffins using sticks to scratch a part of their body.
Three researchers from the University of Oxford and the South Iceland Nature Research Centre have found evidence of tool use by puffins—the first evidence of tool use by any seabird. In their paper published in Proceedings of the National Academy of Sciences, Annette Fayet, Erpur Snær Hansen and Dora Biro describe their evidence of puffins using sticks to scratch a part of their body.
Nature Communications, Published online: 03 January 2020; doi:10.1038/s41467-019-13661-w Wind changes the surface of the Earth, but the surface characteristics of the planet also impact the winds above it. Here, the authors propose a feedback process in which wind erosion in the western Gobi Desert alters the thermal properties of the surface, which in turn increases near-surface winds.
Nature Communications, Published online: 03 January 2020; doi:10.1038/s41467-019-13765-3 Constituitively active CRISPR systems have the risk of adverse off-target effects. Here the authors use chemical masking and activation of gRNA to control activity.
Nature Communications, Published online: 03 January 2020; doi:10.1038/s41467-019-13784-0 Raman probes which operate in the cellular silent region are of interest for live cell imaging. Here, the authors report on the development of a water soluble polydiacetylene Raman probe with enhanced Raman signal in the silent region which can be functionalised for organelle targeting and demonstrate applica
Nature Communications, Published online: 03 January 2020; doi:10.1038/s41467-019-13871-2 Cratons represent the ancient cores of continental plates and are generally thought to have been stable since the Archean. Here however, the authors combine seismic analysis with kimberlite data to infer complete destruction of cratonic lithosphere in some places of the African continent.
Nature Communications, Published online: 03 January 2020; doi:10.1038/s41467-019-13840-9 Quantification and characterization of circRNAs in sequencing data remains challenging, hindering efforts to understand their roles and regulation. The algorithm introduced here enables accurate circRNA quantification and permits insight into competitive splicing between linear and circular isoforms.
Nature Communications, Published online: 03 January 2020; doi:10.1038/s41467-019-13749-3 Identifying the composition of multiphase inorganic compounds from XRD patterns is challenging. Here the authors use a convolutional neural network to identify phases in unknown multiphase mixed inorganic powder samples with an accuracy of nearly 90%.
Nature Communications, Published online: 03 January 2020; doi:10.1038/s41467-019-13803-0 Identification of cancer driver genes, especially those that can act as tumour suppressors or oncogenes depending on context, remains a challenge. Here, the authors introduce Moonlight, a tool that integrates multi-omic data to address this challenge and identify numerous dual-role cancer genes.
Nature Communications, Published online: 03 January 2020; doi:10.1038/s41467-019-13831-w DNA methylation is associated with complex traits and the expression of genes and proteins. Here, Zaghlool et al. perform epigenome-wide association studies for 1,123 plasma proteins, replicate obtained protein (p)QTMs in an independent cohort and find overlap of pQTMs with expression QTMs and previously repo
The Atlantic Multidecadal Oscillation (AMO) and the Pacific Decadal Oscillation (PDO) do not appear to exist, according to a team of meteorologists who believe this has implications for both the validity of previous studies attributing past trends to these hypothetical natural oscillations and for the prospects of decade-scale climate predictability.
Of the most feared terrorist leaders the United States has hunted and killed this century—from Osama bin Laden to Abu Bakr al-Baghdadi—no death ever had the significance of the one America just dealt. The killing of Iran's Quds Force commander, Qassem Soleimani, in a U.S. strike yesterday in Baghdad wasn't just the targeted assassination of a state military leader. It marked a dangerous new chapt
PLUS. Der passerer fortsat kun omkring 2.500 biler om dagen over Kronprinsesse Marys Bro, en syvendedel af trafikken på den gamle og gratis bro. Bestyrelsesformand afviser, at det giver grund til bekymring.
A new generation of advanced remote-sensing satellites is compiling a granular record of what is happening in the world's most distant and difficult-to-reach latitudes in the climate-change era. Two NASA probes, Grace-Fo and ICESat-2, are collecting data on some of Earth's fastest-disappearing ice sheets.
There have more than 300 cases since April 2019 of attackers trying to gain control of UK mobile phone numbers by obtaining porting authorisation codes (PACs)
Navy ships plucked hundreds of people from beaches and tens of thousands were urged to flee Friday before hot weather and strong winds in the forecast worsen Australia's already-devastating wildfires.
The death toll from floods in Indonesia's capital rose to 43 on Friday as rescuers found more bodies amid receding floodwaters, disaster officials said.
Google har lukket ned for at tilknytte kameraer fra kinesiske Xiaomi til Google Home, efter at en sikkerhedsbrist gjorde, at flere brugere så billeder fra andres kameraer i stedet for deres egne.
Researchers at the Department of Energy's Oak Ridge National Laboratory have developed a quantum chemistry simulation benchmark to evaluate the performance of quantum devices and guide the development of applications for future quantum computers.
A study led by Kevin Reed, Ph.D., Assistant Professor in the School of Marine and Atmospheric Sciences (SoMAS) at Stony Brook University, and published in Science Advances, found that Hurricane Florence produced more extreme rainfall and was spatially larger due to human-induced climate change.
School test scores often show gaps in performance between white and non-white students. Understanding the complex reasons behind this can help reduce those gaps and promote social equality, explains Mary Paula Arends-Kuenning, associate professor of agricultural and consumer economics at the University of Illinois.
Serena Auñón-Chancellor, M.D., M.P.H., Clinical Associate Professor of Medicine at LSU Health New Orleans School of Medicine's branch campus in Baton Rouge, is the lead author of a paper describing a previously unrecognized risk of spaceflight discovered during a study of astronauts involved in long-duration missions. The paper details a case of stagnant blood flow resulting in a clot in the inter
A study out of the University of Hyogo in Awaji, Japan, details the stress-reducing benefits to office workers that even a small plant situated within easy viewing can impart.
A study out of the University of Hyogo in Awaji, Japan, details the stress-reducing benefits to office workers that even a small plant situated within easy viewing can impart.
Researchers at Columbia University and University of California, San Diego, have introduced a novel "multi-messenger" approach to quantum physics that signifies a technological leap in how scientists can explore quantum materials.
Conventional measures of innovation suggest that only big cities foster new ideas, but a more comprehensive measure developed at Penn State shows that innovation is widespread even in rural places not typically thought of as innovative. This "hidden" innovation brings economic benefits to businesses and communities, according to researchers, whose findings will help decision makers think in new wa
The global low-carbon revolution could be at risk unless new international agreements and governance mechanisms are put in place to ensure a sustainable supply of rare minerals and metals, a new academic study has warned.
Global heating blamed as summer and winter records tumble in 2019 A series of high temperature records were broken in the UK in 2019 as a consequence of the climate crisis, the Met Office has said. The hottest temperature ever recorded in the UK was exceeded on 25 July in Cambridge, where the thermometer hit 38.7C (101F). The record for the hottest February day was also broken, with Kew Gardens i
Few things are more frustrating than re-running the same fight with your partner or family. Here's how to resolve it once and for all If you have been in a relationship for a year or more, you will know exactly what "that argument" is. It is the one that keeps going round and round, always ending where it started. "You never pick up your dirty clothes, even though you know it drives me crazy." "Y
T he National Theatre barely sleeps. The last bar staff leave the hulking building on the south bank of the River Thames in Central London at 3 a.m. The first goods trucks arrive at 6 a.m. Rufus Norris doesn't sleep much either. All artistic directors are plate spinners, but being in charge of the National, which employs about 4,000 people, is particularly demanding. Norris is the closest thing B
Bushfires across Australia, snowfall in Afghanistan, New Year's Eve celebrations in New York, ski jumping in Germany, the Mars 2020 Rover in California, the "Els Enfarinats" battle in Spain, the Rose Parade in California, the Polar Bear plunge on Coney Island, and much more.
Happy New Year from the Science Weekly team. There is no new episode this week as we all take a festive break. The team will be back with a new episode on Friday 10 January Continue reading…
The world scientific community is waging a difficult and prolonged war on cancer. New research in the field of immunogenic cell death can extend the area of drugs application and ensure patients' protection from relapse after therapy.Cancer treatment is not just the removal of the tumor cells from the body, and chemotherapy. The doctors' aim is to provide a scenario that would prevent tumor cells
The global low-carbon revolution could be at risk unless new international agreements and governance mechanisms are put in place to ensure a sustainable supply of rare minerals and metals, a new academic study has warned.
Happy New Year from the Science Weekly team. There is no new episode this week as we all take a festive break. The team will be back with a new episode on Friday 10 January. Help support our independent journalism at theguardian.com/sciencepod
PLUS. Et nyt sikringsanlæg på Randers Station skulle være taget i brug i august 2018, men er fortsat ikke færdigt. Derfor bliver det højst benyttet fem år, inden det skal skrottes igen.
Beware! Imagine you are on a trip to Paris. There is so much to see and do, but you decide to go to the local zoo. You are walking around, admiring all the interesting animals. There are beautiful big cats lounging about. There are enormous giraffes feeding on plants. You feast your […]
The United States has killed Major General Qassem Soleimani, the commander of the Islamic Revolutionary Guard Corps's Quds Force. The United States is now in a hot war with Iran after having waged war via proxies for the past several decades. This doesn't mean war, it will not lead to war, and it doesn't risk war. None of that. It is war. I don't claim to be an expert on Iran—when I served as dep
Do you think the world will hold people/politicians accountable for environmental negligence the same way they have with war crimes. Eg Selling off water supplies. Pollutants in oceans. submitted by /u/random_smurf [link] [comments]
Inspired by the patterns of multicellularity in choanoflagellates, the closest living relatives of animals, we quantify the biophysical processes underlying the morphogenesis of rosette colonies in the choanoflagellate Salpingoeca rosetta. We find that rosettes reproducibly transition from an early stage of 2-dimensional (2D) growth to a later stage of 3D…
Targeting Clostridium difficile infection is challenging because treatment options are limited, and high recurrence rates are common. One reason for this is that hypervirulent C. difficile strains often have a binary toxin termed the C. difficile toxin, in addition to the enterotoxins TsdA and TsdB. The C. difficile toxin has…
In the tetrapod limb, the digits (fingers or toes) are the elements most subject to morphological diversification in response to functional adaptations. However, despite their functional importance, the mechanisms controlling digit morphology remain poorly understood. Here we have focused on understanding the special morphology of the thumb (digit 1), the…
Carbon dioxide (CO2), the major product of metabolism, has a strong impact on cerebral blood vessels, a phenomenon known as cerebrovascular reactivity. Several vascular risk factors such as hypertension or diabetes dampen this response, making cerebrovascular reactivity a useful diagnostic marker for incipient vascular pathology, but its functional relevance, if…
By constructing an in vivo-assembled, catalytically proficient peroxidase, C45, we have recently demonstrated the catalytic potential of simple, de novo-designed heme proteins. Here, we show that C45's enzymatic activity extends to the efficient and stereoselective intermolecular transfer of carbenes to olefins, heterocycles, aldehydes, and amines. Not only is this a…
Cysteine thiols of many cancer-associated proteins are attractive targets of anticancer agents. Herein, we unequivocally demonstrate a distinct thiol-targeting property of gold(III) mesoporphyrin IX dimethyl ester (AuMesoIX) and its anticancer activities. While the binding of cysteine thiols with metal complexes usually occurs via M–S bond formation, AuMesoIX is unique in…
Human noroviruses (HuNoVs) cause sporadic and epidemic outbreaks of gastroenteritis in all age groups worldwide. We previously reported that stem cell-derived human intestinal enteroid (HIE) cultures support replication of multiple HuNoV strains and that some strains (e.g., GII.3) replicate only in the presence of bile. Heat- and trypsin-treatment of bile…
The reaction scheme of rotary catalysis and the torque generation mechanism of bovine mitochondrial F1 (bMF1) were studied in single-molecule experiments. Under ATP-saturated concentrations, high-speed imaging of a single 40-nm gold bead attached to the γ subunit of bMF1 showed 2 types of intervening pauses during the rotation that were…
The prediction of interresidue contacts and distances from coevolutionary data using deep learning has considerably advanced protein structure prediction. Here, we build on these advances by developing a deep residual network for predicting interresidue orientations, in addition to distances, and a Rosetta-constrained energy-minimization protocol for rapidly and accurately generating structure…
Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and the leading cause for acute viral hepatitis worldwide. The virus is classified as a member of the genus Orthohepevirus A within the Hepeviridae family. Due to the absence of a robust cell culture model for HEV…
In a survey of nearly 10,000 veterans newly separated from military service, most were satisfied with their work and social well-being, but more than half reported chronic physical health problems, and a third reported chronic mental health conditions.
Theoretical simulations suggest structural maintenance of chromosome proteins coil not only around each other but also around the strands of DNA they help manipulate. These strands are formed into loops that regulate transcription and other cellular processes.
Sidste opgave før juleferien gik ud på at finde et antal ens lys, n, der vil kunne brænde ned samtidig, når man den første aften tænder det ene lys og lader det brænde i en time, anden aften tænder man 2 passende valgte lys og lader dem brænde i en time osv., indtil man sidste aften tænder alle l…
This holiday season is expected to break records for domestic road travel. More Americans are planning to travel abroad in 2020. These affordable products will make your next trip less stressful and more efficient. None As we enter a new year and a new decade, it's time once again to set goals and plan for the coming months. For many professionals and families, a recurring resolution is to travel
Testicular cancer can be prevented from coming back using half the amount of chemotherapy that is currently used, a new clinical trial has shown. The new trial showed that giving men one cycle of chemotherapy was as effective at preventing men's testicular cancer from coming back as the two cycles used as standard.
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BioNyt Videnskabens Verden (www.bionyt.dk) er Danmarks ældste populærvidenskabelige tidsskrift for naturvidenskab. Det er det eneste blad af sin art i Danmark, som er helliget international forskning inden for livsvidenskaberne.
Bladet bringer aktuelle, spændende forskningsnyheder inden for biologi, medicin og andre naturvidenskabelige områder som f.eks. klimaændringer, nanoteknologi, partikelfysik, astronomi, seksualitet, biologiske våben, ecstasy, evolutionsbiologi, kloning, fedme, søvnforskning, muligheden for liv på mars, influenzaepidemier, livets opståen osv.
Artiklerne roses for at gøre vanskeligt stof forståeligt, uden at den videnskabelige holdbarhed tabes.
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BioNyt Videnskabens Verden (www.bionyt.dk) er Danmarks ældste populærvidenskabelige tidsskrift for naturvidenskab. Det er det eneste blad af sin art i Danmark, som er helliget international forskning inden for livsvidenskaberne.
Bladet bringer aktuelle, spændende forskningsnyheder inden for biologi, medicin og andre naturvidenskabelige områder som f.eks. klimaændringer, nanoteknologi, partikelfysik, astronomi, seksualitet, biologiske våben, ecstasy, evolutionsbiologi, kloning, fedme, søvnforskning, muligheden for liv på mars, influenzaepidemier, livets opståen osv.
Artiklerne roses for at gøre vanskeligt stof forståeligt, uden at den videnskabelige holdbarhed tabes.
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