In a paper that made the cover of the journal Applied Physics Letters, an international team of researchers has demonstrated an innovative technique for increasing the intensity of lasers. This approach, based on the compression of light pulses, would make it possible to reach a threshold intensity for a new type of physics that has never been explored before: quantum electrodynamics phenomena.
Artificial enzymes made of treated charcoal could have the power to curtail damaging levels of superoxides, toxic radical oxygen ions that appear at high concentrations after an injury.
In the fight against COVID-19, researchers have developed a new, non-invasive strategy to identify areas at greatest risk for spreading the disease. The team is drawing on data from existing cellular wireless networks to pinpoint potential hotspots for increased viral transmission.
Artificial enzymes made of treated charcoal could have the power to curtail damaging levels of superoxides, toxic radical oxygen ions that appear at high concentrations after an injury.
Infecting volunteers with COVID-19 may provide valuable insights for future rounds of vaccine testing, but would require very strict controls and is unlikely to advance the current slate of vaccines in advanced development, argues a group of infectious disease experts. Though model development would be laborious, it could ultimately be advantageous, allowing researchers to answer a broader range o
The stomach contents of young great white sharks show that they spend a lot of time patrolling the seafloor for meals. — Read more on ScientificAmerican.com
The stomach contents of young great white sharks show that they spend a lot of time patrolling the seafloor for meals. — Read more on ScientificAmerican.com
A new study published in The Journal of Physiology has shown that misfolded protein build-up in the gut could contribute to the development of Alzheimer's-like symptoms in mice. This could suggest a new treatment approach for Alzheimer's disease that would target the gut before symptoms of cognitive deficits appear in patients.
Despite nearly four decades of effort, broad inhibition of oncogenic RAS using small-molecule approaches has proven to be a major challenge. Here we describe the development of a pan-RAS biologic inhibitor composed of the RAS-RAP1–specific endopeptidase fused to the protein delivery machinery of diphtheria toxin. We show that this engineered…
The evaporation of suspension droplets is the underlying mechanism in many surface-coating and surface-patterning applications. However, the uniformity of the final deposit suffers from the coffee-stain effect caused by contact line pinning. Here, we show that control over particle deposition can be achieved through droplet evaporation on oil-wetted hydrophilic surfaces….
Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene leading to the presence of premature termination codons (PTC). Previous transcriptional studies have shown reduced DMD transcript levels in DMD patient and animal model muscles when PTC are present. Nonsense-mediated decay (NMD) has been suggested to be responsible…
The ability of Staphylococcus aureus to infect many different tissue sites is enabled, in part, by its transcriptional regulatory network (TRN) that coordinates its gene expression to respond to different environments. We elucidated the organization and activity of this TRN by applying independent component analysis to a compendium of 108…
The coronavirus disease 2019 (COVID-19) pandemic has placed epidemic modeling at the forefront of worldwide public policy making. Nonetheless, modeling and forecasting the spread of COVID-19 remains a challenge. Here, we detail three regional-scale models for forecasting and assessing the course of the pandemic. This work demonstrates the utility of…
Proteolytic cascades regulate immunity and development in animals, but these cascades in plants have not yet been reported. Here we report that the extracellular immune protease Rcr3 of tomato is activated by P69B and other subtilases (SBTs), revealing a proteolytic cascade regulating extracellular immunity in solanaceous plants. Rcr3 is a…
Base rate neglect, an important bias in estimating probability of uncertain events, describes humans' tendency to underweight base rate (prior) relative to individuating information (likelihood). However, the neural mechanisms that give rise to this bias remain elusive. In this study, subjects chose between uncertain prospects where estimating reward probability was…
Affinity maturation is a powerful technique in antibody engineering for the in vitro evolution of antigen binding interactions. Key to the success of this process is the expansion of sequence and combinatorial diversity to increase the structural repertoire from which superior binding variants may be selected. However, conventional strategies are…
Udviklere fra Disney viser, hvordan de kan lave realistiske deepfake-videoer i en opløsning på 1024×1024. Der er dog stadig et stykke vej før neurale netværk kan overtage opgaven med at lave visuelle effekter til biograffilm og tv-serier.
Organisationen bag utallige kampagner og mange års indsats for sikker trafik mister 15-20 millioner kroner om året og står midt i en fyringsrunde. Til sammenligning er prisen for et tab liv anslået til 34 millioner.
The American pandemic is careening out of control. Yesterday, the United States reported more than 52,000 new cases of the coronavirus, setting a new all-time daily record, according to the COVID Tracking Project at The Atlantic . The surge has put the country's supply of coronavirus tests under strain , especially in some of the worst-hit states, such as Arizona, Texas, Florida, and California.
Stigande vattentemperaturer riskerar att leda till att en stor del av jordens fiskarter dör ut under de kommande 80 åren. Det visar en ny tysk forskarstudie.
The city is undergoing a suburban testing blitz after premier Daniel Andrews revealed hotspots in suburbs were largely caused by extended families Follow live updates in Tuesday's Australia coronavirus blog What we know about the public housing tower 'hard lockdowns' All our coverage of Victoria's 'hard lockdown' in Melbourne On 2 July a stay at home order was placed on 12 postcodes across metrop
As many as 7% of moms-to-be use marijuana while pregnant, and that number is rising fast as more use it to quell morning sickness. But new research suggests such use could have a lasting impact on the fetal brain, influencing children's sleep for as much as a decade.
Intrigued by how reflection changes images in subtle and not-so-subtle ways, a team of researchers used artificial intelligence to investigate what sets originals apart from their reflections. Their algorithms learned to pick up on unexpected clues such as hair parts, gaze direction and, surprisingly, beards – findings with implications for training machine learning models and detecting faked imag
Researchers analyzed the epigenetic and transcriptional regulation in structural cells. They found widespread activity of immune genes, suggesting that structural cells are deeply involved in the body's response to pathogens. Moreover, the study uncovered an epigenetic potential that pre-programs structural cells to engage in the immune response against pathogens. These findings highlight an under
Researchers mapped the signaling network in plants and discovered novel insights about how plants process information about their environment. This gives new potential to strategies to protect crops and help them thrive in the time of increasing droughts.
We look at the risks to consider (and precautions to take) before a restaurant meal. Also: How risky is it to fly on fully booked flights? (Image credit: Malaka Gharib/NPR)
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox . Reading can feel hard right now. It's as if the books themselves got heavier and longer, and closed off like clams. If you're struggling to pry one open, let us help: Today, 11 writers and editor
Keep cleaning easy. (kazuend via Unsplash/) Some kids look back fondly on the "The airplane goes into the hangar" days of spoon feeding. Others see it as an embarrassing proof that they we're not always so ahead-of-the-game of their parents. Regardless, they almost all go through the phase between spoon feeding and using real place settings, a phase in which they spend more time mixing, prodding,
UN predicts mass bankruptcies in Latin America ; Florida confirms 10,000 new cases in one day ; global cases near 11m. Follow the latest updates Cases rising in 37 US states Brazil infections nearing 1.5m Trump awol as president during pandemic, says ex-CIA chief Interactive vaccine tracker: how close are we? See all our coronavirus coverage 1.29am BST English holidaymakers will be able to visit
Blue Steel anyone? (Jakob Owens via Unsplash/) Whether you're doing an elaborate snorkeling shoot or just want to capture a splashy day at the beach, waterproof cameras should be your go to. They offer the image quality and clarity of regular cameras, along with a rugged build designed to safely shoot your aquatic fun. Here are some of our favorite waterproof cameras, built for adventures both bi
Only two people? No problem. (Jaciel Melnik via Unsplash/) The world of tabletop games can be intimidating, with so many choices that seem tailored to larger groups. While many of them can be played with just two people, it's nice to have games specifically tailored for two, where the mechanics are more finely tuned for direct competition (or cooperation). We've picked our favorites, with themes
Hit more of your muscles. ( Victor Freitas /) It can be difficult to get a good fitness routine going at home. Thankfully, there are plenty of full-body workout machines equipped to help you burn as many calories and develop as many muscles as their gym counterparts. Turn on your favorite Netflix show and get pumped. One machine, 50 exercises. (Amazon/) If you really want to work up a sweat, go w
A popular spring break and summertime destination on the South Carolina coast is linked to clusters of coronavirus cases among teenagers and young adults in several states.
There has been a surge in domestic child abuse during the coronavirus pandemic, suggests the experience of one specialist UK children's hospital, reported in Archives of Disease in Childhood.
Researchers have developed a safer and more efficient way to deliver a promising new method for treating cancer and liver disorders and for vaccination.
While scientists are trying to find a vaccine for COVID-19, the rabies virus continues to kill 59,000 people every year. But unlike COVID, a vaccine has existed for more than a century. Vaccinating dogs can stop the spread to humans, but systemic challenges make that easier said that done. In a new study, scientists where grassroots campaigns to stop rabies work — and where they need to be couple
Researchers have developed a safer and more efficient way to deliver a promising new method for treating cancer and liver disorders and for vaccination.
New research finds that prospective teachers appear more likely to misperceive Black children as angry than white children, which may undermine the education of Black youth.
With more than 53,000 new cases, the country set a record for the sixth time in nine days. The Supreme Court granted Alabama's request to restore voting restrictions during the pandemic.
1,175 calculators attempt to solve every everyday math problem for you. All free to use, it's amazing how many aspects of life get a calculator. Bookmark this collection — it's hard to imagine you won't someday need it. It's true that high-school calculus teachers torture their students with them, but it's also true that once some degree of mastery is in hand. Mathematicians love a good — efficie
In her timely new book "The Great Indoors," Emily Anthes explores the vagaries of lives lived predominantly indoors, and the burgeoning research connecting indoor environments to behavior and health. From innovative architecture to invisible microbes, Anthes reveals influences both great and small.
Eating this close to a person outside your COVID bubble could be a long way off (Wictor Karkocha/Unsplash/) Follow all of PopSci's COVID-19 coverage here , including tips on cleaning groceries , ways to tell if your symptoms are just allergies , and a tutorial on making your own mask . Many Americans are clamoring to get back to normal life, whether the novel coronavirus is gone or not ( and it m
Cold Shoulder Overall, the Earth is getting warmer at an ominous rate — which, according to an overwhelming majority of climate scientists , is probably a result of greenhouse gas emissions. That's why it's so interesting, as Mashable points out in a fascinating new story , that one spot in the middle of the Atlantic Ocean appears to be getting colder each year. The Blob A new paper in the journa
Slow Boil New research suggests that climate change threatens to wipe out significantly more species of fish than previously thought. If average global temperatures rise by five degrees Celsius — that'd be a global warming nightmare scenario — then New Scientist reports that 60 percent of all fish species could go extinct by the year 2100. It's grim news, as previous studies predicted that fish w
New research shows that a specific change in the SARS-CoV-2 coronavirus virus genome, previously associated with increased viral transmission and the spread of COVID-19, is more infectious in cell culture.
Center for BrainHealth® recently examined underlying brain networks in long-term cannabis users to identify patterns of brain connectivity when the users crave or have a desire to consume cannabis. While regional brain activation and static connectivity in response to cravings have been studied before, fluctuations in brain network connectivity had not yet been examined in cannabis users. The find
Breast cancer patients who are overweight or obese might benefit less from treatment with docetaxel, a common chemotherapy drug, than lean patients, a new study finds.
The end of a successful hunt from back in the day, with the Magic Bus in the background. (Tyler Freel /) This story originally featured on Outdoor Life . Earlier this month, the Alaska National Guard used a Chinook helicopter to lift and carry out "The Bus." If you're not familiar, this is the bus that the wandering Chris McCandless perished in after a short stint of trying to live off the land i
Cases of Covid-19 increased across much of the country this week, raising fears that the virus that causes it could spread further during gatherings over the Fourth of July weekend. The holiday arrives as the national death toll from Covid-19 passes 128,000 — roughly one quarter of the world total.
Neuroscientists describe for the first time how relationships between different odors are encoded in the brain. The findings suggest a mechanism that may explain why individuals have common but highly personalized experiences with smell, and inform efforts better understand how the brain transforms information about odor chemistry into the perception of smell.
Several interacting exoplanets have already been spotted by satellites. But a new breakthrough has been achieved with, for the first time, the detection directly from the ground of an extrasolar system of this type. Astronomers have discovered an unusual planetary system, dubbed WASP-148.
A team of engineers built a new robot that can automate one of the unsightlier parts of coronavirus medical work: jabbing a cotton swab as far as it can go up a patient's nose. The robot, developed by the Korea Institute of Machinery & Materials (KIMM) under the Ministry of Science and ICT, braces itself against a patient's face while a technician in the other room remote controls a disposable sw
A University of California, Riverside, study that sought to determine barriers to health care among Spanish-speaking Latino farmworkers in rural communities has devised an innovative health care service delivery model that addresses many challenges these communities face: mobile health clinics that bring health care services to patients in their community spaces.
1. How to Safely Reopen Colleges and Universities During COVID-19: Experiences From Taiwan ; 2. Urgent Issues Facing Immigrant Physicians in the U.S. in the COVID-19 Era
As many as 7% of moms-to-be use marijuana while pregnant, and that number is rising fast as more use it to quell morning sickness. But new research suggests such use could have a lasting impact on the fetal brain, influencing children's sleep for as much as a decade.
Fish are at a far greater risk from climate change than previously thought, after researchers showed embryos and spawning adults are more susceptible to warming oceans
The offspring of older mothers don't fare as well as those of younger mothers, in humans and many other species. They aren't as healthy, or they don't live as long, or they have fewer offspring themselves. A longstanding puzzle is why evolution would maintain this maternal effect in so many species, since these late-born offspring are less fit to survive and reproduce.
In response to a directive from Congress, the Department of Energy released a report this week assessing the risks of a 50-year-old cracking and crumbling concrete nuclear waste repository in the Marshall Islands, but the findings did little to ease the concerns of Marshallese leaders in the Central Pacific.
How old is your tail-wagging bundle of joy in human years? According to the well-known "rule of paw," one dog year is the equivalent of 7 years. Now scientists say it's wrong. Dogs are much older than we think, and researchers devised a more accurate formula to calculate a dog's age based on the chemical changes in the DNA as organisms grow old.
Find the right spots. ( Manja Vitolic via Unsplash/) Mounting wall shelves and picture frames is a relatively simple task that should look effortless by design, but there's more to it than meets the eye. If the object you're hanging up has any substantial weight to it, it's essential to ensure that the screws are entering a wall stud behind your plaster or drywall for it to be truly secured. Keep
The offspring of older mothers don't fare as well as those of younger mothers, in humans and many other species. They aren't as healthy, or they don't live as long, or they have fewer offspring themselves. A longstanding puzzle is why evolution would maintain this maternal effect in so many species, since these late-born offspring are less fit to survive and reproduce.
The display looks slick and the internal battery easily outlasted long cooks on a full charge. (Weber/) No matter how many barbecue tutorials you watch on YouTube or instructional articles you read online, experience is always the best teacher. Meat is expensive, however, and putting eight hours into a sub-par finished product can be frustrating. Weber's Connect Smart Grilling Hub aims to eschew
Opt Out After a nine-year-long legal battle, a federal court just ruled that Facebook's ubiquitous online tracking could be considered a violation of anti-wiretapping laws. You know those little "like" widgets that seem to punctuate just about every website? They actually gather information about everyone who visits the site, whether they have a Facebook account or not, Gizmodo reports . That on
Intrigued by how reflection changes images in subtle and not-so-subtle ways, a team of Cornell University researchers used artificial intelligence to investigate what sets originals apart from their reflections. Their algorithms learned to pick up on unexpected clues such as hair parts, gaze direction and, surprisingly, beards – findings with implications for training machine learning models and d
Between thriving at work, reaching your fitness goals, and pursuing the zillion other ambitions you have, life can get pretty busy. And, finding the time to do all those things and get to bed at a reasonable hour can seem like a superhuman feat. The key is equipping yourself with the right tools and know-how to do those things smarter and faster. That's where The Superhuman Lifetime Subscription
Power Up Boeing staff in Mississippi just powered up the core stage of the super-heavy-duty Space Launch System (SLS) rocket that it's building for NASA, which is intended to launch huge amounts of hardware to be used in the upcoming Artemis missions to the Moon, and after that possibly Mars. "It's very rewarding," Boeing director Mark Nappi told Space.com of the test. "It's the first time that t
In a new study in rotifers (microscopic invertebrates), scientists tested the evolutionary fitness of older-mother offspring in several real and simulated environments, including laboratory culture, under threat of predation in the wild, or with reduced food supply. They confirmed that this effect of older maternal age, called maternal effect senescence, does reduce evolutionary fitness of the off
In an article published today in Science, a multidisciplinary research team from more than 10 universities and research institutes outlines how integrating a more diverse set of species and environments could enhance the biomedical research cycle.
Some people are better protected than others against urinary tract infections. This may be because their bodies produce more of a protein called uromodulin. An interdisciplinary research team has now found out exactly how this helper protein brings relief when nature calls and how this knowledge might benefit the treatment and prevention of these painful inflammations.
In a new meta-study, experts from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) have published ground-breaking findings on the effects of climate change for fish stock around the globe.
University of Oregon chemists have made substantial gains in enhancing the catalytic water dissociation reaction in electrochemical reactors, called bipolar membrane electrolyzers, to more efficiently rip apart water molecules into positively charged protons and negatively charged hydroxide ions.
In a study that takes another look at histones' origins, researchers report these proteins, known for DNA-packing, may have evolutionary roots in early life in helping to maintain the use of metals like copper – fundamental for biological processes, but which became toxic to eukaryotes as they adapted to global oxygenation.
Free-flowing filaments of Uromodulin protect against urinary tract infections (UTIs) by duping potentially harmful bacteria to attach to their fishbone-like molecular architecture – rather than to sensitive urinary tract tissues – before being flushed out of the body during urination, researchers report.
For people infected by HIV in the subset of cases involving several variants of the virus, and for which disease progression is usually faster, a new modeling study suggests the number of infection-initiating viral variants is primarily determined by how long the source partner has been infected.
Spawning fish and embryos are far more vulnerable to Earth's warming waters than fish in other life stages, according to a new study, which uniquely relates fish physiological tolerance to temperature across the lifecycles of nearly 700 fish species.
Researchers at Eindhoven University of Technology (TU/e), the Netherlands have developed a new method to convert gaseous, low-weight hydrocarbons into more complex molecules by illuminating the hydrocarbons with light in the presence of a suitable catalyst.
While scientists are trying to find a vaccine for COVID-19, the rabies virus continues to kill 59,000 people every year. But unlike COVID, a vaccine has existed for more than a century. Vaccinating dogs can stop the spread to humans, but systemic challenges make that easier said that done. In a new study, scientists where grassroots campaigns to stop rabies work– and where they need to be coupled
For the first time, scientists have shown that the bacterium that causes the tick-borne disease anaplasmosis interferes with tick gene expression for its survival inside cells and to spread to a new vertebrate host. Girish Neelakanta of Old Dominion University and colleagues report these findings in a study published July 2nd in PLOS Genetics.
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs with transmission through the respiratory route. However, clinical evidence suggests that the intestine may present another viral target organ. Indeed, the SARS-CoV-2 receptor angiotensin-converting enzyme 2 (ACE2) is h
The CRISPR RNA (crRNA)–guided nuclease Cas13 recognizes complementary viral transcripts to trigger the degradation of both host and viral RNA during the type VI CRISPR-Cas antiviral response. However, how viruses can counteract this immunity is not known. We describe a listeriaphage (LS46) encoding an anti-CRISPR protein (AcrVIA1) that inactivates the type VI-A CRISPR system of Listeria seeligeri
Eukaryotic histone H3-H4 tetramers contain a putative copper (Cu 2+ ) binding site at the H3-H3' dimerization interface with unknown function. The coincident emergence of eukaryotes with global oxygenation, which challenged cellular copper utilization, raised the possibility that histones may function in cellular copper homeostasis. We report that the recombinant Xenopus laevis H3-H4 tetramer is
Species' vulnerability to climate change depends on the most temperature-sensitive life stages, but for major animal groups such as fish, life cycle bottlenecks are often not clearly defined. We used observational, experimental, and phylogenetic data to assess stage-specific thermal tolerance metrics for 694 marine and freshwater fish species from all climate zones. Our analysis shows that spawni
Bacterial biofilms represent a basic form of multicellular organization that confers survival advantages to constituent cells. The sequential stages of cell ordering during biofilm development have been studied in the pathogen and model biofilm-former Vibrio cholerae . It is unknown how spatial trajectories of individual cells and the collective motions of many cells drive biofilm expansion. We d
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an unprecedented public health crisis. Because of the novelty of the virus, there are currently no SARS-CoV-2–specific treatments or vaccines available. Therefore, rapid development of effective vaccines against SARS-CoV-2 are urgently needed. Here, we developed
Dielectric capacitors can store and release electric energy at ultrafast rates and are extensively studied for applications in electronics and electric power systems. Among various candidates, thin films based on relaxor ferroelectrics, a special kind of ferroelectric with nanometer-sized domains, have attracted special attention because of their high energy densities and efficiencies. We show th
The direct-current (dc) Josephson effect provides a phase-sensitive tool for investigating superfluid order parameters. We report on the observation of dc Josephson supercurrents in strongly interacting fermionic superfluids across a tunneling barrier in the absence of any applied potential difference. For sufficiently strong barriers, we observed a sinusoidal current-phase relation, in agreement
The role of reduced dimensionality in high-temperature superconductors is still under debate. Recently, ultracold atoms have emerged as an ideal model system to study such strongly correlated two-dimensional (2D) systems. Here, we report on the realization of a Josephson junction in an ultracold 2D Fermi gas. We measure the frequency of Josephson oscillations as a function of the phase difference
Direct activation of gaseous hydrocarbons remains a major challenge for the chemistry community. Because of the intrinsic inertness of these compounds, harsh reaction conditions are typically required to enable C(sp 3 )–H bond cleavage, barring potential applications in synthetic organic chemistry. Here, we report a general and mild strategy to activate C(sp 3 )–H bonds in methane, ethane, propan
Longevity has been a long-standing concern for hybrid perovskite photovoltaics. We demonstrate high-resilience positive-intrinsic-negative perovskite solar cells by incorporating a piperidinium-based ionic compound into the formamidinium-cesium lead-trihalide perovskite absorber. With the bandgap tuned to be well suited for perovskite-on-silicon tandem cells, this piperidinium additive enhances t
During sexual transmission, the high genetic diversity of HIV-1 within an individual is frequently reduced to one founder variant that initiates infection. Understanding the drivers of this bottleneck is crucial to developing effective infection control strategies. Little is known about the importance of the source partner during this bottleneck. To test the hypothesis that the source partner aff
Microbial communities are essential to fundamental processes on Earth. Underlying the compositions and functions of these communities are nutritional interdependencies among individual species. One class of nutrients, cobamides (the family of enzyme cofactors that includes vitamin B 12 ), is widely used for a variety of microbial metabolic functions, but these structurally diverse cofactors are s
Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography–computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnos
Nature, Published online: 02 July 2020; doi:10.1038/d41586-020-02010-3 Divers found stone tools belonging to people that lived more than 7,000 years ago. Plus: an image library with offensive tags has been pulled offline, and a fire has destroyed important specimens at a museum in Brazil.
Nature, Published online: 02 July 2020; doi:10.1038/d41586-020-01987-1 A research institute that appointed Pier Paolo Pandolfi as its scientific director has reversed its decision after internal protests.
New research from The University of Texas at Dallas suggests food deserts might be more prevalent in the U.S. than the numbers reported in government estimates. In a feasibility study published in the journal Frontiers in Public Health, scholars found that the methods used by the U.S. Department of Agriculture (USDA) to identify areas with low access to healthy food are often outdated and narrow i
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