One member of a larger family of oxygen sensing enzymes could offer a viable target for triple negative breast cancer (TNBC), researchers report in a new study. The findings might offer hope to this subset of patients who have few effective treatment options and often face a poor prognosis.
Summit Lake in remote northwest Nevada is home to the only self-sustaining, robust, lake population of Lahontan Cutthroat Trout, North America's largest freshwater native trout species. Research to understand the reasons why this population continues to thrive, where others have not, will be used to protect the fish and its habitat – as well as to apply the knowledge to help restore other Nevada l
Researchers investigating the ways that plants protect themselves — from insects to pathogens — have discovered an "on-off" switch that controls plant defensive mechanisms. The switch turns on immune responses minutes after an attack and later sends a deactivation signal to avoid self-inflicted damage. The finding lays the groundwork for improved plant disease resistance and food stability.
Hurricane Douglas is a major hurricane tracking through the Central Pacific Ocean on a forecast track to Hawaii. NASA's Aqua satellite used infrared light to identify strongest storms and coldest cloud top temperatures and found them surrounding the eyewall of the powerful hurricane. In addition, images from NASA-NOAA's Suomi NPP satellite were used to generate an animated track of Douglas' moveme
Alaska is getting wetter. A new study spells out what that means for the permafrost that underlies about 85% of the state, and the consequences for Earth's global climate.
Todd LeDuc challenges the Diesel Brothers to a desert race! Stream Full Episodes of Diesel Brothers: https://go.discovery.com/tv-shows/diesel-brothers/ Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Join us on Facebook: https://www.facebook.com/DieselBrothersTV https://www.facebook.com/Discovery Follow on Twitter: https://twitter.com/DieselBrosTV https://twitter.com/Discovery We're on I
Jews imprisoned in a ghetto during the second world war stamped out a big typhus outbreak using public health measures like those currently being used to fight covid-19
Both the US and the UK claim to have evidence that Russia has tested an anti-satellite weapon on July 15. The weapon test has been classified as "non-destructive," meaning it didn't target any other satellites. That doesn't mean it can't, just that the Russians may have wanted to test their new weapon without tipping their hand on what they had. An extensive report from Time details what we know
Science has shown that service dogs can benefit some veterans with PTSD. But the exact role service dogs play in the day-to-day lives of veterans is less known. A recent study shows what trained tasks service dogs perform the most often and which ones are the most helpful to veterans with post-traumatic stress disorder. The study found that the task of disrupting episodes of anxiety ranked among t
Researchers identified a discordant phenomenon in which a subset of patients displayed profoundly decreased expression of the transgenic TCR over time, despite the transgenic TCR being present at the DNA level.
The 'Gamma Factory initiative' — an international team of scientists — is currently exploring a novel research tool: They propose to develop a source of high-intensity gamma rays using the existing accelerator facilities at CERN. To do this, specialized ion beams will be circulated in the SPS and LHC storage rings, which will then be excited using laser beams so that they emit photons within the
A research team is investigating how pathogens influence the immune response of their host with genetic variation. This enables Staphylococcus aureus bacteria to develop antibiotic resistance and improve their chances of survival.
Alaska is getting wetter. A new study spells out what that means for the permafrost that underlies about 85% of the state, and the consequences for Earth's global climate.
All the storage you'll need. (Dylan Gillis via Unsplash/) Thanks to the advent and proliferation of SSD technology, external hard drives are becoming faster, more convenient, and in some cases cheaper. It's easy now to get a whopping 10 TB in a regular hard drive for the price of a 2 TB SSD card. So which hard drive should you turn to when your computer is overflowing with MP3s and WMVs? It depen
Summer blockbusters have started to look the same in recent years: iterations from the same franchises, with comic-book superheroes leading the pack again and again. But because of the coronavirus pandemic, the 2020 summer-movie season never really began. With Hollywood's biggest films delayed for months, or indefinitely, I've assembled a list of unconventional and underrated movies with a much m
Corrosive Evidence The aviation industry is experiencing a massive drop in demand during the ongoing coronavirus pandemic. That means thousands of commercial airliners are being put in storage, patiently waiting to take to the skies again — that is, if we're ever willing to get in a plane again. Having the jets grounded for so long may turn into a significant safety issue in the future, NPR repor
Most meteorites that have landed on Earth are fragments of planetesimals, the very earliest protoplanetary bodies in the solar system. Scientists have thought that these primordial bodies either completely melted early in their history or remained as piles of unmelted rubble. But a family of meteorites has befuddled researchers since its discovery in the 1960s. The diverse fragments, found all ove
Scientists from the University of Sheffield have found that genetic mutations in MRSA allow it to evolve and become more resistant to antibiotics such as penicillin.
Scientists from the University of Sheffield have found that genetic mutations in MRSA allow it to evolve and become more resistant to antibiotics such as penicillin.
When two pairs of previously healthy young brothers from two families required mechanical ventilation at the intensive care unit in rapid succession, doctors and researchers at Radboud University Medical Center were inclined to consider that genetic factors had a key role in compromising their immune system. Their research identified the gene TLR7 as an essential player in the immune response agai
Russian chemists obtained a new photochromic complex composed of bismuth (III) and viologen cations and used the new compound to create optical memory elements that were shown to be highly efficient and stable. The outcomes of the study may serve to expand the range of microelectronics components in the future.
Research published in the journal Science, using a mix of professional and Raspberry Shake citizen seismic data, finds that lockdown measures to slow the spread of the virus COVID-19 reduced seismic noise by 50% worldwide.
The long-term effects that microgravity — the almost-total weightlessness experienced during near-Earth space travel — have on the human body are still largely unknown. But scientists do have some bad news about what microgravity does to other living things. Ominously, it can make bacteria both more lethal and more resistant to antibiotics, University of Adelaide PhD student Vikrant Minhas wrote
Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
Loss of smell, or anosmia, is one of the earliest and most commonly reported symptoms of COVID-19. A new study identifies the olfactory cell types most vulnerable to infection by the novel coronavirus. Surprisingly, sensory neurons involved in smell are not among the vulnerable cell types.
Researchers detected novel per- and polyfluoroalkyl substances (PFAS) called "fluoroethers" in blood from residents of Wilmington, North Carolina. The fluoroethers represented 24% of the total PFAS detected in the blood of Wilmington residents and appear to leave the body faster than legacy PFAS.
A research team used pioneering technologies to study in detail what happens in brain cells in the direct vicinity of plaques. Their findings show how different cell types in the brain work together to mount a complex response to amyloid plaques which is likely protective at first, but later on damaging to the brain.
A new study found raised levels of transforming growth factor beta-induced protein (TGFBIp) in blood sampled from roughly 100 people hospitalized for COVID-19, and further found that elevated levels of
A new study of human olfactory cells has revealed that viral invasion of supportive cells in the nasal cavity might be driving the loss of smell seen in some patients with COVID-19. The findings show that non-
Loss of smell, or anosmia, is one of the earliest and most commonly reported symptoms of COVID-19. A new study identifies the olfactory cell types most vulnerable to infection by the novel coronavirus. Surprisingly, sensory neurons involved in smell are not among the vulnerable cell types.
A collaboration between Monash Health, the Australian Genomics Health Alliance (AGHA) and researchers at the Monash Biomedicine Discovery Institute has led to the discovery of a rare single gene mutation in a patient that eliminates an immune cell population, namely MAIT cells.
Primates with large brains can master more complex hand movements than those with smaller brains. However, fine motor skills such as using tools can take time to learn, and humans take the longest of all. Large-brained species such as humans and great apes do not actually learn more slowly than other primates but instead start later, researchers at the University of Zurich have shown.
Scientists from the University of Sheffield have found that genetic mutations in MRSA allow it to evolve and become more resistant to antibiotics such as penicillin.
Drug-carrying lipid nanoparticles were created that incorporate neurotranmitters to help them cross the blood-brain barrier in mice. The innovation could overcome many limitations encountered in delivering drugs into the central nervous system.
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a new computational algorithm that has, for the first time, identified a spectrum of mutations in the noncoding portion of the human genome across five major pediatric cancers. The study, which was published today in Science Advances, used the algorithm to analyze more than 500 pediatric cancer patients' mutations and gene ex
Through state-of-the-art mathematical modelling and historical documents, a new study points to community health programs and social distancing practices as the most likely explanations for the epidemic's sudden and mysterious collapse, which was hailed by survivors at the time as a miracle.
Nature, Published online: 24 July 2020; doi:10.1038/d41586-020-02226-3 Emily Sirotich's involvement in a global alliance gave people with rheumatic diseases a driving seat in shaping research on how COVID-19 is affecting them.
Nature, Published online: 24 July 2020; doi:10.1038/d41586-020-02229-0 The quantum effect that underlies everything from photosynthesis to nuclear fusion is not instantaneous. Plus, a Neanderthal gene linked to increased pain sensitivity and how ancient DNA is rewriting our long history with infectious disease.
Art museums are filled with centuries-old paintings with details of plants that today give us clues about evolution and breeding practices. — Read more on ScientificAmerican.com
The project began, in one telling, five years ago, in a castle that overlooks the Bavarian Alps, where three dozen of the world's most successful and rivalrous earth scientists came together for a week of cloistered meetings. They gathered, in part, out of embarrassment. For the past four decades, their field—the study of Earth's natural phenomena, including its land, ocean, and climate—had boome
Researchers have found evidence of gigantic waves of sand, often referred to as "megaripples," slowly moving around on the surface of Mars, as Science reports . Megaripples aren't unique to Mars; they can be found in deserts back here on Earth as well. But the Red Planet's colossal sand dunes, believed to have formed hundreds of thousands of years ago, could be a sign that winds on Mars are even
Art museums are filled with centuries-old paintings with details of plants that today give us clues about evolution and breeding practices. — Read more on ScientificAmerican.com
A research team led by scientists of City University of Hong Kong (CityU) has recently discovered the disordered nanoscale layers at grain boundaries in the ordered intermetallic alloys. The nanolayers can not only resolve the irreconcilable conflict between strength and ductility effectively, but also maintain the alloy's strength with an excellent thermal stability at high temperatures. Designin
Recombination systems are widely used as bioengineering tools, but their sites have to be highly similar to a consensus sequence or to each other. To develop a recombination system free of these constraints, we turned toward attC sites from the bacterial integron system: single-stranded DNA hairpins specifically recombined by the integrase. Here, we present an algorithm that generates synthetic a
Sirtuins are key players of metabolic stress response. Originally described as deacetylases, some sirtuins also exhibit poorly understood mono–adenosine 5'-diphosphate (ADP)–ribosyltransferase (mADPRT) activity. We report that the deacetylase SirT7 is a dual sirtuin, as it also features auto-mADPRT activity. SirT7 mADPRT occurs at a previously undefined active site, and its abrogation alters SirT
Tumor heterogeneity drives disease progression, treatment resistance, and patient relapse, yet remains largely underexplored in invasion and metastasis. Here, we investigated heterogeneity within collective cancer invasion by integrating DNA methylation and gene expression analysis in rare purified lung cancer leader and follower cells. Our results showed global DNA methylation rewiring in leader
Knowledge of the occurrences of water films on minerals is critical for global biogeochemical and atmospheric processes, including element cycling and ice nucleation. The underlying mechanisms controlling water film growth are, however, misunderstood. Using infrared nanospectroscopy, amplitude-modulated atomic force microscopy, and molecular simulations, we show how water films grow from water va
Human skin perceives external mechanical stimuli by sensing the variation in the membrane potential of skin sensory cells. Many scientists have attempted to recreate skin functions and develop electronic skins (e-skins) based on active and passive sensing mechanisms. Inspired by the skin sensory behavior, we investigated materials and electronic devices that allow us to encode mechanical stimuli
Modern meteorite classification schemes assume that no single planetary body could be source of both unmelted (chondritic) and melted (achondritic) meteorites. This dichotomy is a natural outcome of formation models assuming that planetesimal accretion occurred nearly instantaneously. However, it has recently been proposed that the accretion of many planetesimals lasted over 1 million years (Ma).
The progression in the hair follicle cycle from the telogen to the anagen phase is the key to regulating hair regrowth. Dermal papilla (DP) cells support hair growth and regulate the hair cycle. However, they gradually lose key inductive properties upon culture. DP cells can partially restore their capacity to promote hair regrowth after being subjected to spheroid culture. In this study, results
Interpreting the function of noncoding mutations in cancer genomes remains a major challenge. Here, we developed a computational framework to identify putative causal noncoding mutations of all classes by joint analysis of mutation and gene expression data. We identified thousands of SNVs/small indels and structural variants as putative causal mutations in five major pediatric cancers. We experim
Engineered heterostructures formed by complex oxide materials are a rich source of emergent phenomena and technological applications. In the quest for new functionality, a vastly unexplored avenue is interfacing oxide perovskites with materials having dissimilar crystallochemical properties. Here, we propose a unique class of heterointerfaces based on nitride antiperovskite and oxide perovskite m
Chronic human infectious diseases, including malaria, are associated with a large expansion of a phenotypically and transcriptionally distinct subpopulation of B cells distinguished by their high expression of a variety of inhibitory receptors including FcRIIB. Because these B cells, termed atypical memory B cells (MBCs), are unable to respond to soluble antigens, it was suggested that they contr
Human induced pluripotent stem cell (h-iPSC)–derived endothelial cells (h-iECs) have become a valuable tool in regenerative medicine. However, current differentiation protocols remain inefficient and lack reliability. Here, we describe a method for rapid, consistent, and highly efficient generation of h-iECs. The protocol entails the delivery of modified mRNA encoding the transcription factor ETV
Efforts at altering the dismal prognosis of pediatric midline gliomas focus on direct delivery strategies like convection-enhanced delivery (CED), where a cannula is implanted into tumor. Successful CED treatments require confirmation of tumor coverage, dosimetry, and longitudinal in vivo pharmacokinetic monitoring. These properties would be best determined clinically with image-guided dosimetry
Safe and efficient delivery of blood-brain barrier (BBB)–impermeable cargos into the brain through intravenous injection remains a challenge. Here, we developed a previously unknown class of neurotransmitter–derived lipidoids (NT-lipidoids) as simple and effective carriers for enhanced brain delivery of several BBB-impermeable cargos. Doping the NT-lipidoids into BBB-impermeable lipid nanoparticl
Neural development is highly conserved across distantly related species of different brain sizes. Here, we show that the development of manipulative complexity is equally cumulative across 36 primate species and also that its ontogeny recapitulates phylogeny. Furthermore, larger-brained species reach their adult skill levels later than smaller-brained ones, largely because they start later with t
In the context of human disease, the mechanisms whereby transcription factors reprogram gene expression in reparative responses to injury are not well understood. We have studied the mechanisms of transcriptional reprogramming in disease using murine kidney podocytes as a model for tissue injury. Podocytes are a crucial component of glomeruli, the filtration units of each nephron. Podocyte injury
To achieve global elimination of hepatitis C virus (HCV), an effective cross-genotype vaccine is needed. The HCV envelope glycoprotein E2 is the main target for neutralizing antibodies (nAbs), which aid in HCV clearance and protection. E2 is structurally flexible and functions in engaging host receptors. Many nAbs bind to the "neutralizing face" on E2, including several broadly nAbs encoded by th
Van der Waals (VdW) materials have opened new directions in the study of low dimensional magnetism. A largely unexplored arena is the intrinsic tuning of VdW magnets toward new ground states. Chromium trihalides provided the first such example with a change of interlayer magnetic coupling emerging upon exfoliation. Here, we take a different approach to engineer previously unknown ground states, n
The highly dependent interplay of disease, famine, war, and society is examined based on an extreme period during World War II. Using mathematical modeling, we reassess events during the Holocaust that led to the liquidation of the Warsaw Ghetto (1941–1942), with the eventual goal of deliberately killing ~450,000, mostly Jewish residents, many through widespread starvation and a large-scale typhu
Deforestation is both an environmental and a health hazard. (Ales Krivec/Unsplash/) Follow all of PopSci's COVID-19 coverage here , including tips on cleaning groceries , ways to tell if your symptoms are just allergies , and a tutorial on making your own mask . Our current pandemic likely originated in bats . One of these flying mammals somehow came into close contact with a human, or infected a
Most meteorites that have landed on Earth are fragments of planetesimals, the very earliest protoplanetary bodies in the solar system. Scientists have thought that these primordial bodies either completely melted early in their history or remained as piles of unmelted rubble.
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
Since the onset of the pandemic, a growing number of companies have turned to AI to assist with their hiring. The most common systems involve using face-scanning algorithms, games, questions, or other evaluations to help determine which candidates to interview. While activists and scholars warn that these screening tools can perpetuate discrimination, the makers themselves argue that algorithmic
New software techniques make lighting in computer-generated images look more realistic for use in video games, extended reality, and scientific visualization tools.
Facts and data are desperately required so that musicians can get back to entertaining the world While the tentative resumption of the performing arts is officially allowed in England , singing, along with the playing of woodwind and brass instruments, is deemed a special case. Some serious early outbreaks of Covid-19 were associated with choirs and the Department for Digital, Culture, Media and
In recent years, stone stacks have become a popular pastime on social media and in our national parks. Scientists and conservationists warn that such stacks cause ecological damage and risk the survival of many endemic plant and animal species. The problem is one of scale: The more popular the pastime becomes, the great the damage to our natural parks and reserves. The perfect balance of the stac
I reached the Canadian border on the Fourth of July. Usually, the Thousand Islands crossing station between New York and Ontario is busy on summer weekends. Not this time. Eight of the nine lanes were closed, and only one car waited ahead of me in the single open queue. Despite the light traffic, I waited a while for my inspection—and when it was my turn, the car behind me waited a while too. In
In our series "Behind the Byline," we're chatting with Atlantic staffers to learn more about who they are and how they approach their work. Hannah Giorgis is a staff writer who covers culture. This interview has been lightly edited and condensed. Nesima Aberra: How have you been lately? Hannah Giorgis: Today, I am in better spirits than I have been. I think some of that has been that I feel a lit
Malnutrition can lead to stunted growth. A new study of children in Bangladesh implicates 14 types of bacteria in the small intestine. Many children who receive treatment for malnutrition in developing countries never fully recover. They can also experience immune system dysfunction and poor cognitive development that typically cause long-term health issues into adulthood. The bacteria in questio
Nature, Published online: 24 July 2020; doi:10.1038/d41586-020-02215-6 Rob Salguero-Gómez shares how he made the most of lockdown by moving a planned laboratory retreat online.
Nature, Published online: 24 July 2020; doi:10.1038/d41586-020-02193-9 Environmental scientist Sally Brown learnt to connect with others through talking rather than e-mailing, and to not fear asking dumb questions.
Scientists just found out a crucial part of what makes SARS-CoV-2, the virus that causes COVID-19, so infectious: It's capable of sneaking into our cells totally under the radar. It's a devious biological trick. A team of scientists at the University of Texas Health Science Center at San Antonio discovered that the coronavirus contains a particular enzyme, nsp16, that it uses to fool our cells in
Memoirs by politicians and their family members are in a strange genre that must balance compelling storytelling with personal aims. Mary Trump's Too Much and Never Enough is better written than most, Megan Garber argues . (Mary has a master's degree in comparative literature.) But the book's resonance is strongest when it sees the president's niece, a clinical psychologist, take on the work of s
Most neurons are created during embryonic development and have no "backup" after birth. Researchers have generally believed that their survival is determined nearly extrinsically, or by outside forces, such as the tissues and cells that neurons supply with nerve cells. A research team led by Sika Zheng, a biomedical scientist at the University of California, Riverside, has challenged this notion a
A team lead by Pritzker Molecular Engineering researchers has developed an artificial intelligence-led process that uses big data to design new proteins.
The team found that sputum testing detected the RNA of the virus that causes COVID-19 at significantly higher rates while oropharyngeal swab testing had lower rates.
Space Shields One of the biggest challenges facing crewed missions to Mars is figuring out how to protect crewmembers from the onslaught of deadly cosmic rays . Now, scientists at a number of universities say there's growing evidence that an unusual solution could be effective: building shields out of a radiation-absorbing fungus that grows near the Chernobyl Nuclear Power Plant. New Scientist re
With more ethanol in production and a greater ability to upcycle co-products into animal feed ingredients, companies are creating custom products and partnering with University of Illinois researchers to test for quality and digestibility.
One public health director says that even after improvements, 'detective work' is required Coronavirus – latest updates See all our coronavirus coverage The government is still not sharing enough coronavirus data for local authorities to get a full picture of who is being infected, health bosses have said. On Monday, Matt Hancock told parliament he was "putting enhanced levels of data in the hand
University of Rochester researchers are setting a new standard when it comes to producing ultrafast laser pulses over a broader range of wavelengths than traditional laser sources.
When NASA's Aqua satellite passed over the North Atlantic Ocean, it gathered water vapor data on Tropical Storm Gonzalo as tropical storm warnings, a tropical storm watch, and hurricane watch were posted.
With more ethanol in production and a greater ability to upcycle co-products into animal feed ingredients, companies are creating custom products and partnering with University of Illinois researchers to test for quality and digestibility.
By combining genetic ancestry reports with existing historical documentation, The New York Times reports , 23andMe and a team of historians were able to piece together new discoveries about the transatlantic slave trade. During the trans-Atlantic slave trade, some 12.5 million African people were abducted from their homes and brought to America where they were sold into slavery. According to the
With more ethanol in production and a greater ability to upcycle co-products into animal feed ingredients, companies are creating custom products and partnering with University of Illinois researchers to test for quality and digestibility.
It might look good, but don't drink water off your roof. It's gross. (Anna King/Unsplash/) When an inch of rain falls, more than 1,000 gallons of water runs off the average American roof. That's enough free H2O to supply the family inside for a few days and maybe knock a few dollars off the monthly utility bill. But beyond saving money, stocking up on stormwater can help prevent environmental pro
In these topsy turvy times, it can be hard to know how to go about ensuring your long-term financial health. Even before the pandemic, many underestimated their need to be proactive about saving for retirement. It may be tempting to reduce or pause your retirement contributions. Unless absolutely necessary, the best thing to do is ignore the panic and stay the course. No matter where you have bee
A new diamond-based quantum sensing technique gives researchers a map of the intricate movement of electricity on a microscopic scale. New results demonstrate the potential of the technique by revealing the fluid-like electrical currents that flow in graphene, a layer of carbon just one atom thick. Graphene has exceptional electrical properties, and the technique could help researchers better unde
New research finds that individuals with cardiovascular disease risk factors who switched to high-deductible health plans (HDHPs) did not experience increased risk of heart attack or stroke.
In five years, will the winter be mild, and will the following summer be rainy? Unfortunately, reliable answers to such questions are not possible. Nevertheless, there are quantities like the sea surface temperature of the North Atlantic, that are known to promote trends in the weather over Europe. To that, North Atlantic sea surface temperatures are predictable several years into the future – as
Feeding the world's growing population in a sustainable way is no easy task. That's why scientists are exploring options for transforming fruit and vegetable byproducts — such as peels or pulp discarded during processing — into nutritious food ingredients and supplements. Now, researchers have shown that blueberry and persimmon waste can be made into antioxidant-rich powders that might have bene
Extra shine for your floor. (Amazon/) Nothing beats hands-free cleaning—and it truly doesn't get any better than a robot mop. A cousin of the robot vacuum and sister to the robot mop/vacuum hybrid, these powerful machines are dedicated to one thing and one thing only: keeping your floors sparkling clean with advanced mopping features. Robot mops are a great way to sit back and relax while getting
In these topsy turvy times, it can be hard to know how to go about ensuring your long-term financial health. Even before the pandemic, many underestimated their need to be proactive about saving for retirement. It may be tempting to reduce or pause your retirement contributions. Unless absolutely necessary, the best thing to do is ignore the panic and stay the course. No matter where you have bee
The ongoing disruptive changes from efforts to reduce the spread of COVID-19 are having a substantial negative impact on the physical and mental well-being of parents and their children across the United States, according to a new national survey.
Home-made cloth face masks likely need a minimum of two layers, and preferably three, to prevent the dispersal of viral droplets from the nose and mouth that are associated with the spread of COVID-19, a new study indicates.
Tropical storms often begin with an impressive display of pyrotechnics, but researchers have largely overlooked the role of lightning strikes in tropical ecosystems.
Synairgen's share price rises 540% on morning of news of successful drugs trial Coronavirus – latest updates See all our coronavirus coverage Three professors at the University of Southampton school of medicine have this week made a "major breakthrough" in the treatment of coronavirus patients and become paper millionaires at the same time. Almost two decades ago professors Ratko Djukanovic, Step
Headlines appeared last night about Moderna losing a patent case that affects its coronavirus vaccine work. I know from long experience on this blog that any discussion of patent and IP issues has an effect on my readership traffic numbers that looks like I'm paying folks not to click on my links that day, but I'm going to brave this one. What's going on? For starters, it's worth realizing that t
Nature, Published online: 24 July 2020; doi:10.1038/d41586-020-02224-5 Survey finds that standard metrics of success can't completely explain why some candidates get offers and others don't.
In Physical Review Letters, University of Rochester researchers describe a new device, the "stretched-pulse soliton Kerr resonator," that creates an ultrafast laser pulse that is freed from the physical limits endemic to sources of laser light and the limits of the sources' wavelengths. "Simply put, this is the shortest pulse ever from a gain-free fiber source," says William Renninger, assistant p
When NASA's Aqua satellite passed over the North Atlantic Ocean, it gathered water vapor data on Tropical Storm Gonzalo as tropical storm warnings, a tropical storm watch, and hurricane watch were posted.
Heart transplants, donor hearts, and transplant waitlists all fell sharply at the start of the COVID-19 pandemic in the United States, Columbia University researchers have found.
While chatbots are becoming more widespread in health care, it's important to implement them thoughtfully and constantly evaluate them in a variety of ways, Penn authors argue.
As states have moved to reopen nonessential businesses in recent months, many restaurants still haven't turned the lights back on, and more than half of them never will.
Concussions can have a compounding effect on children, leading to long-term cognitive, behavioral, and emotional health consequences, according to researchers.
The Arctic Circle became unbelievably hot on June 20. In the Russian community of Verkhoyansk, temperatures topped 38C, marking what may be the highest air temperature ever recorded within the Arctic.
The Big Quiet The world has been both literally and figuratively standing still during the ongoing pandemic, scientists say. Lockdowns around the globe have drastically reduced human activity, and as a direct result, the ground is shaking far less — a silver lining for those studying seismic signals. In fact, an international team of researchers have found that seismic vibrations generated by hum
The newly discovered comet Neowise is only visible from Earth once every 6,800 years, and photographers who want to document it seek places with high elevation and little smog or light pollution. A place like North Carolina's famed Grandfather Mountain.
In the first study to examine the association between high out-of-pocket costs and adverse cardiovascular events, research led by the Harvard Pilgrim Health Care Institute finds that individuals with cardiovascular disease risk factors who switched to high-deductible health plans (HDHPs) did not experience increased risk of heart attack or stroke. The study, "Association Between Switching to a Hig
The use of medical leave among emergency medical service responders and firefighters in New York during the COVID-19 pandemic is compared with earlier periods.
This is a survey study that examined the knowledge, concerns and behaviors of people living in different COVID-19 exposure zones during the first week of the pandemic in Italy.
If physical distancing measures in the United States are relaxed while there is still no COVID-19 vaccine or treatment and while personal protective equipment remains in short supply, the number of resulting infections could be about the same as if distancing had never been implemented to begin with, reports a team of mathematicians and scientists.
The novel coronavirus changes the appearance of its messenger RNA cap to trick the host cell into not recognizing it is foreign, according to a new study.
A new study looks at the growth of global livestock farming and the threat to biodiversity, and the health risks to both humans and domesticated animals.
A unique and rapid SARS-CoV-2 surrogate virus neutralisation test (sVNT) may be the much needed boost to current COVID-19 investigations to determine infection rate, herd immunity, predicted humoral protection, and vaccine efficacy during clinical trials.
Seismic activity doesn't just come from earthquakes, volcanoes and landslides. Everyday human activity also gives rise to vibrations that travel through the ground as seismic waves, something we call "anthropogenic noise".
Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. The findings suggest phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes.
Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. The findings suggest phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes.
The coronavirus pandemic has led to significant disruption to school education in England. Teachers have made a concerted effort to use digital technology and remote teaching and learning to lessen the impact of this disruption on their students.
Science fiction authors foresaw augmented reality video games, the rise of social media and trends of hyper-consumption, and can help predict future consumer patterns.
In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease.
Cell division is a fundamental process that organisms need to reproduce, grow, and make repairs. But when an error disrupts this complex biological process, cellular abnormalities can lead to diseases, such as cancer, where cells are enabled to grow and divide out of control.
The material's strength comes from the unique arrangement of the ceramic spheres and aluminum of which it's composed. This arrangement is found in some biological structures, such as fish scales. Proteus is currently awaiting a patent. How is the Amazonian Arapaimas fish able to block bites from razor-toothed piranha? The fish's scales are extremely tough and flexible, with a hard outer layer, an
Cell division is a fundamental process that organisms need to reproduce, grow, and make repairs. But when an error disrupts this complex biological process, cellular abnormalities can lead to diseases, such as cancer, where cells are enabled to grow and divide out of control.
China has launched its Tianwen-1 mission to Mars. A rocket holding an orbiter, lander and rover took flight from the country's Hainan province yesterday, with hopes to deploy the rover on Mars's surface by early next year.
An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell. Two injections of the vaccine were sufficient to induce robust immunity, completely preventing SARS-CoV-2 infection in mice.
Far-UVC light is a type of ultraviolet light that kills microbes and viruses and, crucially, seems to be safe to use around humans. Radiation scientist David Brenner describes how we could use this light to stop the spread of SARS-CoV-2, the virus responsible for COVID-19, in hospitals, nursing homes, trains and other public indoor spaces — paving the way for a potentially game-changing tool in t
Rising tree deaths may be reducing the ability of many forests worldwide to lock up carbon by pulling in greenhouse gases from the air. To properly grasp what this means for carbon budgets, scientists need to solve the puzzle of why trees are dying—and how they respond to change.
The events of 2020 are reshaping the way we live, work, teach and learn. And while we have all been affected differently, the impact of the COVID-19 pandemic on women has been particularly significant.
Disease outbreaks shape our cities. Public health concerns have influenced some of the most iconic developments in urban planning. London's sewage systems were developed in response to cholera outbreaks in the 19th century. In the U.S. at the turn of the 20th century, public parks became a popular (though possibly ineffective) way of offering citizens cleaner air to protect them from diseases such
Amid a pandemic when limitations on disinfecting wipes, toilet paper and drugs brought attention—and disruption—to supply chains, new research involving Washington University in St. Louis delivers something of an answer to improving these lines of business:
A world-renowned expert in plastic pollution from the University of Plymouth has contributed to a major new report showing that without immediate and sustained action, the annual flow of plastic into the ocean could nearly triple by 2040.
UFO Task Force The Pentagon's Unidentified Aerial Phenomenon (UAP) Task Force, a program dedicated to investigating UFO sightings, is ready to start reporting some of its findings to the public, The New York Times reports . The news comes after the Senate released a committee report last month outlining spending for the unusual task force. Adversarial Interference Determining whether aliens exist
Examining the structure of a sunflower stem as it matures can help both the plant scientist and biomaterials engineer. That's the premise that Anamika Prasad, an assistant professor in South Dakota State University's Department of Mechanical Engineering, is putting into practice.
Tequila inspires strong opinions in people, just like the Beatles, goat cheese, and the 1988 Detroit Pistons. Some can't stand the smell or taste of it; others relish every sip and wait for the "tequila!" feeling to hit . But the fact is, tequila and its smokier sister, mezcal, have never been more popular outside of their Mexican homeland. The spirits rocketed to the top of the US drinking chart
Using a combination of experiments and mathematical modeling, a team of researchers from the Virginia Tech Department of Biological Sciences in the College of Science and the Fralin Life Sciences Institute are beginning to unravel the mechanisms that lie behind tetraploidy – a chromosomal abnormality that is often found in malignant tumors.
A Nature study authored by a global team of scientists and led by Sumit Chanda, Ph.D., professor at Sanford Burnham Prebys Medical Discovery Institute, has identified 21 existing drugs that stop the replication of SARS-CoV-2, the virus that causes COVID-19.
New RAND report says US should prepare for a triumphant or ascending People's Republic of China — scenarios that not only align with current PRC national development trends but also represent the most challenging future scenarios for the US military.
IPM today welcomed a positive opinion from the EMA on the dapivirine vaginal ring for use by cisgender women ages 18 and older in developing countries to reduce their risk of HIV-1 infection. The monthly ring is the first long-acting HIV prevention product and is designed to help address women's unmet need for new methods given the persistently high rates of HIV they face, especially in sub-Sahara
Examining the structure of a sunflower stem as it matures can help both the plant scientist and biomaterials engineer. That's the premise that Anamika Prasad, an assistant professor in South Dakota State University's Department of Mechanical Engineering, is putting into practice.
Discrimination against minority groups can be difficult to prove. Perpetrators are typically motivated to deny their prejudices, and are not always aware of their biases.
The annual update to the University of Notre Dame's Global Adaptation Initiative (ND-GAIN) Country Index shows sources for some vulnerability indicators have changed, including food dependency and urban concentration.
Antibiotic resistance poses a significant threat to human health on a global scale. It has been predicted that resistant infections will cause 10 million deaths per year by 2050. Given that antibiotics are crucial in many areas of medicine, it is important to understand how antibiotic use influences the likelihood that resistance will emerge in response to treatment.
Fifty years: a breath. A snap of the fingers. Or in the case of Funkadelic's Free Your Mind … And Your Ass Will Follow —recorded in one day, with the whole band tripping on LSD—a single ageless lizard-blink of the third eye. Is it possible that this album sounds heavier and crazier today than it did upon its release in July 1970? I think it's very possible. In the general countercultural churn
Antibiotic resistance poses a significant threat to human health on a global scale. It has been predicted that resistant infections will cause 10 million deaths per year by 2050. Given that antibiotics are crucial in many areas of medicine, it is important to understand how antibiotic use influences the likelihood that resistance will emerge in response to treatment.
On Wednesday, pharmaceutical giant Pfizer and a German partner, BioNTech, announced that they had reached a $1.95 billion deal with the U.S. government for 50 million courses of a Covid-19 vaccine — provided that it works. In the meantime, the U.S. has struggled to implement more low-tech interventions.
Protons are subatomic particles with a positive electric charge. Proton translocation plays a significant role in natural phenomena and manmade technologies. But it remains challenging to control proton conduction and fabrication in biomaterials and devices. In a new report, Chao Ma and an interdisciplinary team of scientists in China, the Netherlands, and Germany, rationally designed proton-condu
Researchers from the University of Alicante's Advanced Materials Laboratory have created an optimal, low-cost methane storage system. The team, led by UA Professor of Inorganic Chemistry Joaquín Silvestre, has used an MOF material (highly porous metal-organic framework). In the pores of this material, it is possible to create the conditions required to replicate gas structures under the sea, where
NASA is planning to watch newborn stars from high up in the Earth's atmosphere, using a gigantic football stadium-sized balloon. NASA's Jet Propulsion Lab is planning to kick off the mission, called ASTHROS , (Astrophysics Stratospheric Telescope for High Spectral Resolution Observations at Submillimeter-wavelengths) in December 2023. The plan is for a 400-foot wide balloon to float over Antarcti
A team of researchers showed that artificial intelligence (AI) could help predict the type of bacteria that caused the infection in patients with pneumonia. The research is presented at ASM Microbe Online, the annual meeting of the American Society for Microbiology.
USTC modified the original proposal to be robust to practical imperfections, and experimentally implement a scalable quantum state verification on two-qubit and four-qubit entangled states with nonadaptive local measurements. The research results were published in Physical Review Letters on July 17th.
Research presented at ASM Microbe Online found that 43% of Staphylococcus bacteria found on exercise equipment in university gyms were ampicillin-resistant, with 73% of those isolates being resistant to multiple additional drugs.
Researchers have shown that there is a low risk for healthy people to acquire Candida auris during travel. The research is presented at ASM Microbe Online, the annual meeting of the American Society for Microbiology.
Edible, biocompatible and biodegradable, these fibers have potential for various medical applications. The results are described in the journal Scientific Reports.
In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease.
In late 2012, after a brief trip into Aleppo to cover the Syrian civil war, I walked up to a Turkish border checkpoint. I expected to be waved through to Kilis, a town a short distance away, where I had been staying. Colleagues of mine who had covered the rebels for longer had told me the crossing was a quiet one, and I shouldn't expect any trouble. Before volunteering for the assignment, I had l
Editor's Note: The Atlantic is making vital coverage of the coronavirus available to all readers. Find the collection here . N early five months into the pandemic, all hopes of extinguishing COVID-19 are riding on a still-hypothetical vaccine. And so a refrain has caught on: We might have to stay home—until we have a vaccine. Close schools—until we have a vaccine. Wear masks—but only until we hav
Landsat 8 is the United States Geological Survey's most recently launched satellite, and it holds the powerful Operational Land Imager (OLI.) The OLI is a powerful multi-spectral imager with a wide dynamic range.
Affirmative action policies have been debated for decades and Supreme Court rulings have guided how universities structure their admission policies. It stands to reason that diverse graduating classes will ultimately lead to diverse workplaces, but this is not always the case.
IT remains one of the hottest careers out there. From 2018 to 2028, the IT sector is expected to expand by at least 12% , far faster than almost every other occupational sector. IT has become the backbone of even the most unexpected companies: Dominos, for example, has called itself a "tech company that sells pizza" , as it completely rebuilt its sales system to make it as easy as possible to buy
Next time you have the urge to check your phone, or have a second cocktail, remember you might not enjoy it as much as you think As anyone who counts a three-year-old among their acquaintances will know, there's a fiery purity to the will of a small child that's difficult to oppose. Once my son has figured out that there's ice-cream in the freezer, and decided he wants some for dessert, my role i
A notable feature of most spiral galaxies is the multitude of arching spiral arms that seemingly spin out from the galaxy's center. In this image, taken with the NASA/ESA Hubble Space Telescope, the stunning silvery-blue spiral arms of the galaxy NGC 4848 are observed in immense detail. Not only do we see the inner section of the spiral arms containing hundreds of thousands of young, bright, blue
Imagine discovering a new artist or designer—whether visual art, fashion, music, or even writing —and becoming a big fan of her work. You follow her on social media, eagerly anticipate new releases, and chat about her talent with your friends. It's not long before you want to know more about this creative, inspiring person, so you start doing some research. It's strange, but there doesn't seem to
Science fiction authors foresaw augmented reality video games, the rise of social media and trends of hyper-consumption, and can help predict future consumer patterns.
The COVID-19 pandemic is a catalyst to accelerate the adoption of technology-enabled patient care for epilepsy, according to a new study published in Epilepsia.
The Quaternary International journal has published a study by the UPV/EHU's Department of Stratigraphy and Palaeontology describing, in detail, the climate changes taking place in the Bay of Biscay over the last 37,000 years. Specifically, it details these changes mainly through the study of foraminifera and ostracod species predominating in various climatic intervals. This palaeoceanographic stud
A UB study published in the journal Neurotherapeutics has validated a new pharmacological target for Alzheimer's disease. The results show the inhibition of the enzyme soluble epoxide hydrolase (sEH) in murine models with the disease reduces the neuroinflammatory process, improving the endogen response of the organism and reducing the neuronal damage and death that cause this type of dementia.
Each installment of The Friendship Files features a conversation between The Atlantic 's Julie Beck and two or more friends, exploring the history and significance of their relationship. This week she talks with two women who have been neighbors in the same New York City apartment building for 20 years. They live alone and have always looked out for each other—but their connection has been extra
Active shooter drills in schools have a negative effect on students' emotional health and yield questionable results, according to a national teen poll. About two-thirds of the poll's respondents indicated their school had either active shooter or other types of lockdown drills. The majority mentioned hiding, but only about 7% reported experiencing drills that follow national recommendations of "
The COVID-19 lockdown period results in a 50% reduction in seismic noise around the world. By analyzing months-to-year-long datasets from over 300 seismic stations around the world, the study was able to show seismic noise reduced in many countries and regions, making it possible to visualize the resulting "wave" moving through China, then to Italy, and around the rest of the world. The seismic l
Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. The treatment consists of new molecules that penetrate the protein shell of the virus and prevent genes from leaving the virus to infect the cell. It
As the current COVID-19 pandemic continues to adversely impact communities and economies across the world, efficiency in testing for the infection and antibodies is vital. A unique and rapid SARS-CoV-2 surrogate virus neutralisation test (sVNT), developed in Singapore, may be the much needed boost to current COVID-19 investigations to determine infection rate, herd immunity, predicted humoral prot
Ciais and colleagues obtained the first bottom-up global land carbon budget from the sum of regional estimates, combining inventories with lateral transfers from the trade of wood and food products and the export of dissolved carbon by rivers to the oceans. Carbon being moved away from ecosystems by lateral fluxes and emitted by fires and as reduced compounds is a large fraction of primary product
If the eyes are the mirror of the soul, then thanks to the translucent corneas, we can look deep into that soul. And thanks to the work of scientists from the IPC PAS we can look into the depths of the cornea itself. And that without touching it! All thanks to the introduction of an innovative method of holographic optical tomography.
The growth of global livestock farming is a threat to our biodiversity and also increases the health risks to both humans and domesticated animals. The patterns that link them are at the heart of a study published in Biological Conservation by a scientist from the Institute of Evolution Sciences of Montpellier (ISEM – CNRS/Université de Montpellier/IRD/EPHE) and the French Agricultural Research Ce
Curtin University researchers have unexpectedly discovered a new way to make crystalline graphite, an essential material used in the making of lithium ion batteries.
Joseph E. Stiglitz, nobelpris-modtager i økonomi, er ikke imponeret over Lomborgs 'False Alarm', der opfordrer til en moderat tilgang til klimaproblematikken, mindre panik og større omtanke for økonomien.
Research conducted at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine found that spinal cord injuries in mice cause an acquired bone marrow failure syndrome that may contribute to chronic immune dysfunction. "We also found that it's possible to overcome certain aspects of spinal cord injury-induced bone marrow failure. This could have an immediate
You're faced with a big decision so your second brain provides what's normally referred to as 'gut instinct', but how did this sensation reach you before it was too late?In a new study in the eNeuro journal, Professor Nick Spencer's laboratory has identified a particular type of neuron in the gut wall that communicates signals to other neurons near the spinal cord and up to the brain.
Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. The findings suggest phage therapy could provide a potential treatment for managing such infections, including those involving antibiotic-resistant microbes.
If physical distancing measures in the United States are relaxed while there is still no COVID-19 vaccine or treatment and while personal protective equipment remains in short supply, the number of resulting infections could be about the same as if distancing had never been implemented to begin with, reports a UCLA-led team of mathematicians and scientists.
A new, 3D-printed technology that was inspired by Lego block toys is designed to help heal broken bones, and could one day even lead to lab-made organs for human transplant.
Desert conditions are harsh, and mosses often spend much of the year in a dormant condition, desiccated and brown, until rain comes. UC Berkeley and Cal State-LA researchers discovered two species of moss that found a hiding place under translucent milky quartz where they can stay moist and green and continue to photosynthesize and grow while other mosses on the soil surface go dormant. This is th
Make sure all surfaces shine. (Sidekix Media via Unsplash/) Stainless steel appliances are the white sneakers of your kitchen. For a brief moment in time, they look amazing, but the wear and tear of daily use leaves its mark all over them way too quickly and easily. Fortunately, there exists a broad range of products focused exclusively on restoring your metallic workhorses to their original smoo
On its way inbound for a Dec. 26, 2019, flyby of Jupiter, NASA's Juno spacecraft flew in the proximity of the north pole of the ninth-largest object in the solar system, the moon Ganymede. The infrared imagery collected by the spacecraft's Jovian Infrared Auroral Mapper (JIRAM) instrument provides the first infrared mapping of the massive moon's northern frontier.
Curtin University researchers have unexpectedly discovered a new way to make crystalline graphite, an essential material used in the making of lithium ion batteries.
The U.N. weather agency warned Friday that average temperatures in Siberia were 10 degrees Celsius (18 Fahrenheit) above average last month, a spate of exceptional heat that has fanned devastating fires in the Arctic Circle and contributed to a rapid depletion in ice sea off Russia's Arctic coast.
Patients with frailty, older age and urinary tract infections (UTIs) are at greatest risk of developing sepsis following infection consultations in primary care, research has found.
A team of investigators at Beth Israel Deaconess Medical Center (BIDMC) has found that in recent years, increasing numbers of these hospitalizations were for conditions for which hospitalization can often be avoided with improvements in outpatient care.
The growth of global livestock farming is a threat to our biodiversity and also increases the health risks to both humans and domesticated animals. The patterns that link them are at the heart of a study published in Biological Conservation by a scientist from the Institute of Evolution Sciences of Montpellier (ISEM—CNRS/Université de Montpellier/IRD/EPHE) and the French Agricultural Research Cent
Work has begun on an ambitious new mission that will carry a cutting-edge 8.4-foot (2.5-meter) telescope high into the stratosphere on a balloon. Tentatively planned to launch in December 2023 from Antarctica, ASTHROS (short for Astrophysics Stratospheric Telescope for High Spectral Resolution Observations at Submillimeter-wavelengths) will spend about three weeks drifting on air currents above th
The growth of global livestock farming is a threat to our biodiversity and also increases the health risks to both humans and domesticated animals. The patterns that link them are at the heart of a study published in Biological Conservation by a scientist from the Institute of Evolution Sciences of Montpellier (ISEM—CNRS/Université de Montpellier/IRD/EPHE) and the French Agricultural Research Cent
A recent mechanical engineering doctoral graduate has created a material for welding in extreme conditions that could minimize equipment needed and operator hazards.
The journal Nature has issued a retraction for a paper it published March 11th called "Hummingbird-sized dinosaur from the Cretaceous period of Myanmar." The editorial staff was alerted to a possible misclassification of the fossil embedded in amber, and after review, agreed with the assessment and issued the retraction.
How much do love and marriage play into overall well-being? A new study quantifies the happiness of married, formerly married, and single people at the end of their lives to find out. The study—published in the Journal of Positive Psychology —examines the relationship histories of 7,532 people followed from ages 18 to 60 to determine who reported to be happiest at the end of their lives. "…if the
There are various (non-mutually exclusive) ways to deny science . You can cherry pick the data and sources you like – there is always someone on the fringe with an opinion counter to the mainstream. You can use the all-purpose method of invoking a grand conspiracy theory. You can replace scientific opinion with pseudoscience. Or, if you have sufficient background scientific knowledge, you can mag
It's about way more than just baseball and apple pie. (Photo by Jose Francisco Morales on Unsplash/) Three slices of fresh apple pie sit on the kitchen counter, and you and a trio of buddies are drooling over them. What do you do? Try to grab a piece right away, and you risk a tussle with a pal who makes the same move. Hesitate, and you might get nothing. Maybe it's smarter to reach for the small
The scientific group led by Professor Ivan Stoikov has been engaged in supramolecular chemistry research for more than 20 years and is well-known in the professional community. The main undertaking of the research group is the study of new, biologically significant materials obtained on the basis of macrocyclic compounds.
The mechanism of a protein which transports ammonium across cell membranes has been discovered in research led at the University of Strathclyde, which could lay the foundations for preventing infection.
Room temperature ionic liquids (ILs), a special class of molten salts, promise far greater electrochemical performance compared to conventional aqueous solutions due to a suite of novel and tunable properties. Over the past two decades, ILs have been explored as a means of improving a range of different technologies, from energy storage and conversion to catalysis to electroplating of metals and s
The mechanism of a protein which transports ammonium across cell membranes has been discovered in research led at the University of Strathclyde, which could lay the foundations for preventing infection.
A new study led by researchers at The Australian National University (ANU) provides a clearer snapshot of conditions during the last ice age—when global ice sheets were at their peak—and could even lead to better models for future climate projections.
This week, we discuss whether the Chinese-owned app is as much of a security risk as some claim, and where everyone would go if the platform went dark.
A radiation-absorbing fungus discovered in Chernobyl blocked harmful cosmic rays on the International Space Station and may help protect future Mars colonies
COVID-19 could amplify the persistent lack of diversity in higher education—but the pandemic also gives us a chance to fix it — Read more on ScientificAmerican.com
Justice Neil Gorsuch is a proud textualist. According to this approach, what Congress intended, or expected, when it passed a law doesn't matter. What matters are the words printed on paper. In practice, Justice Gorsuch will strictly follow the text of statutes, no matter what result it yields. Last month, he decided that the 1964 Civil Rights Act has always prohibited LGBTQ discrimination. Every
The United States accused Russia of test-firing an anti-satellite weapon in space, warning that the threat against Washington's systems was "real, serious and increasing."
If, through some scientific malfunction, you found yourself transported 70 million years into the past, you might be safer from certain hungry reptiles than you think.
UC Davis scientists spent years editing a sex-determining gene into bovine embryos using Crispr. In April, Cosmo arrived—and his DNA reveals how far the field has to go.
New evidence supports the potential for intrauterine spread of SARS-CoV-2 to a developing fetus. it's uncommon, but something to take seriously. Also some good news from the AAP regarding the care of babies born to mothers with COVID-19!
Om senest to år skal der rulle tog fra perronerne i Malmø og Stockholm mod henholdsvis Bruxelles og Hamborg. Det har den svenske regering endeligt besluttet.
Et ufærdigt vandkraftværk i Etiopien, der skal levere elektricitet til 65 mio. mennesker har udviklet sig til et slagsmål med Sudan og Egypten. Nu advarer forskere efter forliste forhandlinger landene imellem.
Nature, Published online: 24 July 2020; doi:10.1038/d41586-020-02184-w Features at ancient Greek sanctuary would have aided visitors with impaired mobility.
Nature, Published online: 23 July 2020; doi:10.1038/d41586-020-02221-8 Advances in technology are accelerating the search for drugs to arm the immune system against SARS-CoV-2. Plus, China's mission to Mars launches successfully and stone tools hint that people arrived much earlier than thought in the Americas.
The extinct African crocodile species Crocodylus checchiai may be closely related to American crocodile species alive today, according to a study published in Scientific Reports. The findings suggest that crocodiles may have migrated from Africa to America during the Late Miocene epoch (11-5 million years ago).
This week, Congress will decimate the economy, in an unfortunately literal sense: It will cut unemployment-insurance payments to more than 25 million people, more than one in 10 American adults. When it does, the coronavirus recession, already historic in its severity, will become far, far worse. The CARES Act, the coronavirus-relief legislation, included a huge expansion of the unemployment-insu
Editor's Note: In the next five years, most of America's most experienced teachers will retire. The Baby Boomers are leaving behind a nation of more novice educators. In 1988, a teacher most commonly had 15 years of experience. Less than three decades later, that number had fallen to just three years leading a classroom . The Atlantic' s "On Teaching" project is crisscrossing the country to talk
New C.D.C. guidance for reopening schools takes a political tone. Japanese officials remain narrowly focused on Tokyo's nightlife as the country's outbreak spreads.
For years, money for flood protection in the Houston area went mostly to richer neighborhoods. A new approach prioritizes minority communities, and it's stirring up resentments.
New reports cast doubt on early claims smoking offered protection from disease At the beginning of the pandemic, smokers may have thought they had little to worry about, as there was a sliver of good news for them: a study circulating on social media suggested smoking could be associated with a lower risk of contracting Covid-19. That's not the full story. Related: Biden predicts Trump will try t
I Sverige finns ett femtiotal stickmyggarter, varav åtta kan sprida malaria. Det är framför allt två som man anser har varit delaktiga i tidigare spridning av sjukdomen i Sverige, källarfrossmyggan, Anopheles messeae, och stallfrossmyggan, Anopheles atroparvus. Den första gången vi kan läsa om malaria i Sverige är när biskop Israel Erlandsson berättar om hur han gick i skola i Linköping på 1200-ta
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17443-7 During eukaryotic chromosome replication cells utilize ring-shaped CMG helicase that separates the two strands of the DNA double helix. Here the authors reveal that CMG helicase activity is inhibited by duplex DNA engagement at the fork, which is relieved by binding of RPA to the lagging-strand template.
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17307-0 Inflammation, immune cells and the host microbiota are intimately linked in the pathophysiology of obesity and diabetes. Here the authors show mucosal-associated invariant T cells fuel inflammation in the tissues and serve a function in promoting metabolic breakdown, polarising macrophage populations and inducin
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17495-9 SARS-CoV-2 expresses a 2′-O RNA methyltransferase (MTase) that is involved in the viral RNA cap formation and therefore a target for antiviral therapy. Here the authors provide the structure of nsp10-nsp16 with the panMTase inhibitor sinefungin and report that the development of MTase inhibitor therapies that ta
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17519-4 Implementations of quantum walks on ion trap quantum computers have been so far limited to the analogue simulation approach. Here, the authors implement a quantum-circuit-based discrete quantum walk in one-dimensional position space, realizing a Dirac cellular automaton with tunable mass parameter.
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17530-9 Current light-inducible Cre-loxP systems have minimal capacity for deep tissue penetration. Here, the authors present a far-red light-induced split Cre-loxP system for in vivo genome engineering.
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17486-w It is unclear how the T-tubule structure of skeletal muscle, which regulates coordinated muscle contraction, forms. Here, the authors develop a four-dimensional quantitative model for T-tubule formation in zebrafish, based on live imaging, proposing a dynamic endocytic capture model.
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17493-x At Li-garnet interface, the poor interfacial wettability due to Li2CO3 passivation causes large resistance and unstable contact. Here the authors propose a Li2CO3-affiliative mechanism for air-accessible interface engineering of garnet electrolyte with superior wettability via facile liquid metal painting.
Nature Communications, Published online: 24 July 2020; doi:10.1038/s41467-020-17498-6 Wild teas are considered as valuable resource for studying domestication and breeding. Here, Zhang et al. report genome of wild tea DASZ and transcriptome of 217 accessions, which clarify pedigree of Chinese tea cultivars and show tea may not have undergone long-term artificial directional selection on flavor-re
Investigation shows rigorous testing at hospital trust led to rise in cases in 'pariah town' Coronavirus – latest updates See all our coronavirus coverage During the height of the coronavirus pandemic, Barrow-in-Furness was labelled a "pariah town" when it emerged the Cumbrian local authority had by far the highest number of positive cases per head of population in England. Now, analysis of posit
Rådgivere fra Cowi har fået adgang til data fra 100.000 personbiler fra VW-gruppen i Danmark. Data fra bilerne giver blandt andet indblik i, hvordan vejtrafikken har artet sig under nedlukningen af samfundet.
More than a month after New York's June 23 primary elections, state election officials are still counting votes. In some legislative districts, they haven't even started counting absentee votes. In the best-case scenario, election officials hope to declare winners by the first Tuesday in August—six weeks after Election Day. It might take a lot longer than that. Election officials in New York City
At La Jolla Institute for Immunology (LJI) researchers are dedicated to finding a way to stop plaques from forming in the first place. In a new study, LJI scientists show that certain T lymphocytes, a type of white blood cell, that start out trying to fight the disease can end up increasing inflammation and making atherosclerosis cases even worse.
The ongoing disruptive changes from efforts to reduce the spread of COVID-19 are having a substantial negative impact on the physical and mental well-being of parents and their children across the country, according to a new national survey published today in Pediatrics.
The novel coronavirus changes the appearance of its messenger RNA cap to trick the host cell into not recognizing it is foreign, according to a study reported by researchers from UT Health San Antonio.
The COVID-19 pandemic has thrown millions of Americans into unemployment, highlighting the impracticality of living paycheck to paycheck, which a shocking number of Americans must do. Yet pandemic unemployment is just a glimpse of the fallout the US can expect in a future where more and more jobs are automated. Is universal basic income the answer? In this video, a range of experts from economist
A growing number of researchers think until there's an effective vaccine, the coronavirus will simply persist in the population, causing illness indefinitely. Better to squelch the spread instead. (Image credit: Josh Edelson/AFP via Getty Images)
In "The Precipice," Toby Ord sees humanity at a crossroads, and examines the daunting existential risks to our survival, and how we might confront them. Will we address anthropogenic threats head-on? What do we owe to our descendants? Ord is looking to the future of humanity — and how to ensure it arrives.
Spiders may build their webs to catch prey, but trials in Slovenian forests show they also grab onto DNA, which can help us monitor biodiversity in a less invasive manner
Delay is result of coronavirus pandemic and technical challenges as troubled project is set to cost £6.8bn Nasa has announced that the often delayed James Webb space telescope (JWST) is to be delayed once more. Instead of a launch on 30 March 2021, the mission has now slipped to 31 October 2021. The seven-month delay is the result of impacts from the coronavirus pandemic, as well as technical cha
More than 140 teams of researchers are racing to develop a safe and effective coronavirus vaccine Researchers around the world are racing to develop a vaccine against Covid-19, with more than 140 candidate vaccines now tracked by the World Health Organization (WHO). Continue reading…
Ethiopia said this week it had hit its first-year target for filling the Grand Ethiopian Renaissance Dam, a concrete colossus 145 metres (475 feet) high that has fuelled tensions with downstream nations for nearly a decade.
Vietnam, one of Asia's biggest consumers of wildlife products, has suspended all imports of wild animal species "dead or alive" and vowed to "eliminate" illegal markets across the country.
The number of forest fires in the Pantanal, the world's largest tropical wetlands, has nearly tripled in 2020 compared to the same period last year, according to satellite data released Thursday.
Vietnam, one of Asia's biggest consumers of wildlife products, has suspended all imports of wild animal species "dead or alive" and vowed to "eliminate" illegal markets across the country.
The first hurricane to threaten the United States since the start of the coronavirus pandemic is presenting new challenges to Hawaii officials long accustomed to tropical storms.
The U.S. Fish and Wildlife Service says there's enough scientific evidence that two rare plants in Nevada's desert could go extinct to warrant a year-long review of whether to list them as endangered species, including one at the center of a fight over a proposed lithium mine.
The U.S. Fish and Wildlife Service says there's enough scientific evidence that two rare plants in Nevada's desert could go extinct to warrant a year-long review of whether to list them as endangered species, including one at the center of a fight over a proposed lithium mine.
The introduction of a master's degree loan scheme in England "substantially" broadened the socioeconomic class of people able to further their higher education.
Converting carbon dioxide to methanol, a potentially renewable alternative fuel, offers an opportunity to simultaneously form an alternative fuel and cut down on carbon dioxide emissions.
Strategic networking is key to career success, and not just for humans. A new study of wild bottlenose dolphins reveals that in early life, dolphins devote more time to building connections that could give them an edge later on.
Strategic networking is key to career success, and not just for humans. A new study of wild bottlenose dolphins reveals that in early life, dolphins devote more time to building connections that could give them an edge later on.
Small farms in Zambia that use the latest hybrid seed for maize, along with improving health on neutral soils, help reduce deforestation and tackle climate change, Cornell University researchers report this month in Global Environmental Change.
While it seems a likely culprit Tasmania's infamous curried scallop pie is not to blame for the disappearance of the smooth handfish Sign up here to get an email whenever First Dog cartoons are published Get all your needs met at the First Dog shop if what you need is First Dog merchandise and prints Continue reading…
Konsortium af danske forskere vil erstatte medicinsk zink med protein, som nænsomt jager sygdomsfremkaldende bakterier ud af tarmen på smågrise under afvænning. Landbruget ser stort potentiale.
A cheetah at rest in Kenya, flamenco dancing in Spain, tennis at a Berlin airport, a giant spoon on an English trail, a baby hippo in Mexico, an online mud festival in South Korea, the night sky above Syria, wildfires in Greece, concerts in Australia and Germany, a Chinese mission to Mars, and much more
Boston College chemists have used a tandem catalytic system to efficiently convert carbon dioxide to methanol. By encapsulating multiple catalysts involved in the tandem process in nanoporous materials called metal-organic frameworks, the team reports achieving superior performance by eliminating catalyst incompatibility. The method could be applied to other tandem catalytic processes, allowing mo
Covid-19 fik sat gang i udviklingshastigheden i Region Hovedstaden. Ny løsning betyder mere tid til kritiske intensivpatienter og kan redde menneskeliv, når det gælder.
Researchers have identified new pathways in an RNA-based virus where inhibitors, like medical treatments, unbind. The finding could be beneficial in understanding how these inhibitors react and potentially help develop a new generation of drugs to target viruses with high death rates, like HIV-1, Zika, Ebola and SARS-CoV2, the virus that causes COVID-19.
A new analysis finds that without immediate and sustained action, the annual flow of plastic into the ocean could nearly triple by 2040. The study also identifies solutions that could cut this volume by more than 80% using technologies available today, if key decision-makers make system-wide changes.
One in 11 flowers carries disease-causing parasites known to contribute to bee declines, according to a new study that identifies how flowers act as hubs for transmitting diseases to bees and other pollinators.
Some supposedly inert ingredients in common drugs — such as dyes and preservatives — may potentially be biologically active and could lead to unanticipated side effects, according to a preliminary new study.
Researchers have confirmed that Heartland virus, an emerging pathogen with potentially dire consequences for those infected, is present in Lone Star ticks in two Illinois counties hundreds of miles apart. Lone Star ticks were first detected in Illinois in 1999 but had not been found to be infected with Heartland virus in the state.
America's oldest citizens say they've been through worse, but many older adults are feeling the stress of COVID-19 and prolonged social distancing measures, according to a new study.
Adults aged 60 and up have fared better emotionally compared to younger adults (18-39) and middle-aged adults (40-59) amid the COVID-19 pandemic, according to new research.
Neurobiologists have found new evidence that specific calcium channel subunits play a crucial role in the development of excitatory and inhibitory synapses.
Researchers have identified new pathways in an RNA-based virus where inhibitors, like medical treatments, unbind. The finding could be beneficial in understanding how these inhibitors react and potentially help develop a new generation of drugs to target viruses with high death rates, like HIV-1, Zika, Ebola and SARS-CoV2, the virus that causes COVID-19.
A new study found that lung ultrasound was highly sensitive for detecting abnormalities in patients with coronavirus disease (COVID-19), with B-lines, a thickened pleural line, and pulmonary consolidation the most commonly observed features. Additionally, the authors found that lung ultrasound features can be used to reflect both the infection duration and disease severity.
In people with mild cases of COVID-19, antibodies against SARS-CoV-2 — the virus that causes the disease — drop sharply over the first three months after infection, decreasing by roughly half every 36 days, a new study finds. If sustained at that rate, the antibodies would disappear within about a year.
Animal cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein (LDL), which releases cholesterol in lysosomes. The cholesterol moves to the endoplasmic reticulum (ER), where it inhibits production of LDL receptors, completing a feedback loop. Here we performed a CRISPR-Cas9 screen in human SV589 cells for genes required for LDL-derived…
Developing expertise in any field usually requires acquisition of a wide range of skills. Most current studies on perceptual learning have focused on a single task and concluded that learning is quite specific to the trained task, and the ubiquitous individual differences reflect random fluctuations across subjects. Whether there exists…
In randomized experiments, Fisher-exact P values are available and should be used to help evaluate results rather than the more commonly reported asymptotic P values. One reason is that using the latter can effectively alter the question being addressed by including irrelevant distributional assumptions. The Fisherian statistical framework, proposed in…
Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both organelles has been implicated in numerous diseases. Recently, interorganelle contacts between mitochondria and lysosomes were identified and found to regulate mitochondrial dynamics. However, whether mitochondria–lysosome contacts serve additional functions by facilitating the direct transfer of metabolites
The ATP-binding cassette (ABC) transporter of mitochondria (Atm1) mediates iron homeostasis in eukaryotes, while the prokaryotic homolog from Novosphingobium aromaticivorans (NaAtm1) can export glutathione derivatives and confer protection against heavy-metal toxicity. To establish the structural framework underlying the NaAtm1 transport mechanism, we determined eight structures by X-ray crystallo
Current strategies to direct therapy-loaded nanoparticles to the brain rely on functionalizing nanoparticles with ligands which bind target proteins associated with the blood–brain barrier (BBB). However, such strategies have significant brain-specificity limitations, as target proteins are not exclusively expressed at the brain microvasculature. Therefore, novel strategies which exploit alternati
Pacemaker neurons exert control over neuronal circuit function by their intrinsic ability to generate rhythmic bursts of action potential. Recent work has identified rhythmic gut contractions in human, mice, and hydra to be dependent on both neurons and the resident microbiota. However, little is known about the evolutionary origin of…
A better understanding of how antibiotic exposure impacts the evolution of resistance in bacterial populations is crucial for designing more sustainable treatment strategies. The conventional approach to this question is to measure the range of concentrations over which resistant strain(s) are selectively favored over a sensitive strain. Here, we instead…
Programmed cell death (PCD) in filamentous fungi prevents cytoplasmic mixing following fusion between conspecific genetically distinct individuals (allorecognition) and serves as a defense mechanism against mycoparasitism, genome exploitation, and deleterious cytoplasmic elements (i.e., senescence plasmids). Recently, we identified regulator of cell death-1 (rcd-1), a gene controlling PCD in germi
The field-effect electron mobility of aqueous solution-processed indium gallium oxide (IGO) thin-film transistors (TFTs) is significantly enhanced by polyvinyl alcohol (PVA) addition to the precursor solution, a >70-fold increase to 7.9 cm2/Vs. To understand the origin of this remarkable phenomenon, microstructure, electronic structure, and charge transport of IGO:PVA film are…
A CT scan technique that splits a full X-ray beam into thin beamlets can deliver the same quality of image at a much reduced radiation dose, according to a new study. The technique, demonstrated on a small sample in a micro CT scanner, could potentially be adapted for medical scanners and used to reduce the amount of radiation millions of people are exposed to each year.
A CT scan technique that splits a full X-ray beam into thin beamlets can deliver the same quality of image at a much reduced radiation dose, according to a new study. The technique, demonstrated on a small sample in a micro CT scanner, could potentially be adapted for medical scanners and used to reduce the amount of radiation millions of people are exposed to each year.
Strategic networking is key to career success, and not just for humans. A study of bottlenose dolphins reveals that in early life, dolphins devote more time to building connections that could give them an edge later on. Analyzing nearly 30 years of records for some 1700 dolphins in Australia, researchers find that dolphins under age 10 seek out peers and activities that could help them forge bonds
Scientists say the noise from boats and ships slows down the activity of baby fish on coral reefs, which leaves them more vulnerable to their predators.
Most reptiles move slower when temperatures drop, but venomous rattlesnakes appear to be an exception. The cold affects them, but not as much as scientists expected.
Forest ecologist report finding "clear evidence of a contraction of the breeding period" among boreal birds in Finland over a 43-year span for which good quality data were available.
A new modified version of the SARS-CoV-2 spike protein has a 10-fold higher expression rate in cell cultures than an earlier version that forms the basis of some candidates currently in clinical trials. Vaccine manufacturers could swap in the new version and produce vaccine doses at much higher rates, researchers say.
To predict and help control the spread of mosquito-borne illnesses, it's important to know where and why certain mosquitoes got their taste for biting humans in the first place. Now, researchers have identified two major factors: a dry climate and city life. Based on these findings, they predict that increased urbanization in the coming decades will mean even more human-biting mosquitoes in the fu
Researchers have compiled genetic data from consenting 23andMe research participants to paint a more complete picture of African ancestry in the New World. By linking genetic data with slave trade historical records, the findings reinforce harsh truths about slavery in the Americas and uncover insights into its history, including the methods used to suppress and exploit Africans once they disembar
In a new paper, experts set forth a framework to increase significantly the number, quality and type of daily tests for detecting SARS-CoV-2, the virus that causes COVID-19, and help reduce inequities for underserved populations that have been disproportionally affected by the disease.
A research team has developed a technique for tracking online foreign misinformation campaigns in real time, which could help mitigate outside interference in the 2020 American election.
A new article shows that an annual investment of $30 billion should be enough to offset the costs of preventing another global pandemic such as COVID-19.
Researchers report on the decline of emergent medical, surgical and obstetric hospitalizations at the medical center during the six-week period following the week of the declaration of the COVID-19 public health emergency in Boston in mid-March 2020.
When drugs to kill microbes are ineffective, host-directed therapy uses the body's own immune system to deal with the infection. This approach is being tested in patients with COVID-19, and now a team of researchers has published a study showing how it might also work in the fight against tuberculosis (TB).
A new study confirms the findings of the large scale British trial of steroid use for COVID-19 patients and advances the research by answering several key questions: Which patients are most likely to benefit from steroid therapy? Could some of them be harmed? Can other formulations of steroids substitute for the agent studied in the British trial?
Kids with all different skin colors need to see teachers from underrepresented groups. (August de Richelieu from Pexels/) This story originally featured on Working Mother . "We moved here for the schools." It's a popular refrain of suburban families wealthy enough to afford the high real-estate taxes that go toward funding well-rated public schools but not wealthy enough, or not interested, to se
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox . SHUTTERSTOCK / THE ATLANTIC 1. The pandemic, and its aftereffects, could stifle U.S. population growth. The country's birth rate, for example, will likely decline. "Between births and deaths, we'
Researchers have isolated antibodies from several COVID-19 patients that, to date, are among the most potent in neutralizing the SARS-CoV-2 virus. These antibodies could be produced in large quantities by pharmaceutical companies to treat patients, especially early in the course of infection, and to prevent infection, particularly in the elderly.
Cancer patients diagnosed more than 24 months ago are more likely to have a severe COVID-19 infection, research has found. Cancer patients of Asian ethnicity or who were receiving palliative treatment for cancer were also at a higher risk of death from COVID-19.
Teen museum docents can boost the experiences, learning, and information retention of visitors to informal learning sites. The positive effects hold true across age groups regardless of museum type, but were most apparent in children ages 9 to 11. Informal learning sites—such as museums , zoos, and aquariums —often have programs for teenage docents, or educators that serve as a way for the teens
The results of the first statewide random sample study in the United States to measure the spread of COVID-19 indicated a general population prevalence of about 2.8 percent in Indiana.
Disruption of normal brain network function in hippocampus cells may explain loss of spatial memory in people with Alzheimer's disease, according to a new study. People with Alzheimer's disease frequently suffer from spatial memory loss, such as not recognizing where they are, and forgetting where they put their belongings. They often show a wandering symptom, which is also a feature of spatial m
US Secretary of State's reported comments 'untrue, unacceptable and without foundation' says WHO ; Trump cancels Jacksonville RNC ; Bolsonaro not distancing despite positive test . Follow the latest updates US surpasses 4m Covid-19 cases as states dial back reopening South Africa sees spike in excess deaths suggesting high Covid-19 toll South Korea goes into recession as Australia flags huge defi
Despite the political tensions between the United States and China, scientists in the two countries are working together more than ever to study the COVID-19 virus, a new study suggests.
Mothers with COVID-19 infection are unlikely to pass the virus to their newborn babies, if correct hygiene precautions are observed, according to a small observational study published in The Lancet Child & Adolescent Health journal.
Using a simple urine test alongside routine imaging for patients with adrenal masses could speed up adrenal cancer diagnosis, improving patient's prognosis and reducing the need for invasive diagnostic procedures, a new multi-centre study published in The Lancet Diabetes & Endocrinology has found.
Home-made cloth face masks likely need a minimum of two layers, and preferably three, to prevent the dispersal of viral droplets from the nose and mouth that are associated with the spread of COVID-19, indicates a video case study published online in the journal Thorax.
For just the second time ever, astrophysicists have spotted a spectacular flash of ultraviolet (UV) light accompanying a white dwarf explosion. An extremely rare type of supernova, the event is poised to offer insights into several long-standing mysteries, including what causes white dwarfs to explode, how dark energy accelerates the cosmos and how the universe creates heavy metals, such as iron.
Researchers have conducted one of the first studies of its kind to quantify the happiness of married, formerly married and single people at the end of their lives to find out just how much love and marriage played into overall well-being.
In nature, organisms often support each other in order to gain an advantage. However, this kind of cooperation appears to contradict the theory of evolution proposed by Charles Darwin: Why would organisms invest valuable resources to help others? Instead, they should rather use them for themselves, in order to win the evolutionary competition with other species. A new study has now solved this puz
The hurricanes in the Caribbean became more frequent and their force varied noticeably around the same time that classical Mayan culture in Central America suffered its final demise: We can gain these and other insights by looking at the climate archive.
Antibiotic treatment in early life impedes brain signalling pathways that function in social behavior and pain regulation in mice, a new study has found.
Researchers combined avalanche physics with ecosystem data to create a computational method for predicting extreme ecological events. The method may also have applications in economics and politics.
Nature, Published online: 23 July 2020; doi:10.1038/d41586-020-02219-2 How a PhD student found a way to be productive during lockdown after weeks of inactivity.
Scientific Reports, Published online: 24 July 2020; doi:10.1038/s41598-020-69652-1 Author Correction: Sentinel optical and SAR data highlights multi-segment faulting during the 2018 Palu-Sulawesi earthquake (M w 7.5)
Researchers combined avalanche physics with ecosystem data to create a computational method for predicting extreme ecological events. The method may also have applications in economics and politics.
A new study suggests that goosebumps are part of a larger system that not only keeps us warm, but also helps hair to heal. The sympathetic nerve system reacts to cold air with goose skin. If it stays on long enough, it orders new hair growth. The authors note that other, currently unknown, connections between this system and other parts of the body are likely to exist. Everybody gets goosebumps,
In a few days, 30 million Americans will lose the $600 boost in unemployment insurance they've depended on every week. What happens next? Annie Lowrey, the Atlantic staff writer and author of Give People Money , joins to explain. Listen here: Subscribe to Social Distance on Apple Podcasts , Spotify , or another podcast platform to receive new episodes as soon as they're published. What follows is
Meteorologists take advantage of weather data collected by commercial jetliners at different altitudes and locations. Fewer flights mean less data. — Read more on ScientificAmerican.com
Saturn is truly the lord of the rings in this latest snapshot from NASA's Hubble Space Telescope, taken on July 4, 2020, when the opulent giant world was 839 million miles from Earth. A new Saturn image was taken during summer in the planet's northern hemisphere.
China launched an unmanned probe on 23 July to Mars in its first independent mission to visit another planet. China's largest carrier rocket blasted off with the probe at Wenchang Space Launch Centre in the southern island province of Hainan and is expected to reach Mars in February 2021. The Mars-launching season occurs every 26 months when Earth and Mars are at their closest; the Chinese probe
Researchers found that in rats and human cells in vitro, LCCBs cause changes in blood vessels — known as vascular remodeling — that reduce blood flow and increase pressure. Examining epidemiological data, the team also found that LCCBs are associated with a greater risk for heart failure. The findings suggest that care should be taken when prescribing these drugs to patients, particularly older
The new article Evidence from Urban Roads without Bicycle Lanes on the Impact of Bicycle Traffic on Passenger Car Travel Speeds published in Transportation Research Record, the Journal of the Transportation Research Board, demonstrates that bicycles do not significantly reduce passenger car travel speeds on low speed, low volume urban roads without bicycle lanes. The research shows that difference
Strategic networking is key to career success, and not just for humans. A study of bottlenose dolphins reveals that in early life, dolphins devote more time to building connections that could give them an edge later on. Analyzing nearly 30 years of records for some 1700 dolphins in Australia, researchers find that dolphins under age 10 seek out peers and activities that could help them forge bonds
A massive study finds that regional differences in how slaves were treated throughout the Americas are reflected in the DNA of present-day Americans of African descent.
Middle Ground A new study has both good and bad news for the future of the planet. If atmospheric carbon dioxide levels double, things probably won't get as bad as the doomsday, absolute worst-case projections some scientists have made — but, at the same time, we've already screwed the environment up too much for the best-case outcomes, Scientific American reports . The study is "the most importa
A volcano named Sapas Mons dominates this computer-generated view of the surface of Venus. (NASA/JPL/) In many ways—size, density, chemical make-up—Venus is Earth's fiery twin. Sure, this radiation-bombarded, sulfuric-acid-raining, blistering hellscape of a planet is hardly a haven of habitability like our home. But the longstanding hypothesis that Venus, like the Earth, is a volcanically active
Over the past year, SpaceX has been launching hundreds of small broadband internet-beaming satellites into low-Earth orbit as part of its Starlink constellation. The tally as of June: 540 . While the promise of reliable and fast satellite internet accessible from pretty much anywhere in the world sounds pretty promising, not everybody is happy. As it turns out, the tiny satellites are way brighte
The Departed With the presidential election looming, current and recently-departed Facebook employees are reckoning with the many ways that they say the social media platform is damaging society. Software engineer Max Wang left the company after seven years this month, BuzzFeed News reports. As he departed, he posted a 24-minute video and accompanying note urging his fellow employees to take a cl
It is difficult to make very wide frequency combs from silicon waveguides, but clever waveguide engineering may be about to make that task a bit easier.
Small farms in Zambia that use the latest hybrid seed for maize, help reduce deforestation and tackle climate change in a new Cornell University study.
The brain never processes the same information in the same way. Scientists at the Max Planck Institute for Human Cognitive and Brain Sciences (MPI CBS) have found out why this is the case and how it works. A decisive role plays a critical state of the neuronal networks.
Juvenile fishes have one of the highest mortality rates compared to other life stages. Within two days of settling into a reef almost 60 percent are consumed by predators. Our recent study found noisy boats and ships can also affect the prey response of these young fishes.
Juvenile fishes have one of the highest mortality rates compared to other life stages. Within two days of settling into a reef almost 60 percent are consumed by predators. Our recent study found noisy boats and ships can also affect the prey response of these young fishes.
NASA's Aqua satellite used infrared light to identify the strongest storms and coldest cloud top temperatures in Tropical Depression 8, spinning in the Gulf of Mexico.
Florida State University researchers have new insight into the tiny packages that cells use to move molecules, a structure that is key to cellular metabolism, drug delivery and more.
Researchers from BIDMC report on the decline of emergent medical, surgical and obstetric hospitalizations at the medical center during the six-week period following the week of the declaration of the COVID-19 public health emergency in Boston in mid-March 2020. Comparing data from the same period in 2019, the authors found a 35 percent decrease in weekly hospitalizations overall and 45 percent dec
Frequent social media use can impact depressive symptoms over time for LGBTQ youth, according to research from a Washington State University communication professor. Findings highlight the positive influence of a 'social media break' in a supportive environment on mental health, especially for LGBTQ youth. They also demonstrate the value of face-to-face interactions and how many youth may be unawa
Florida State University researchers have new insight into the tiny packages that cells use to move molecules, a structure that is key to cellular metabolism, drug delivery and more.
A Policy Forum article published today in Science shows that an annual investment of $30 billion should be enough to offset the costs of preventing another global pandemic such as COVID-19.
Results from an early-phase clinical trial found CAR-T cell therapy, which attacks cancer cells using a person's reprogrammed immune cells, was highly active in patients with relapsed/refractory Hodgkin lymphoma. The treatment led to the complete disappearance of tumor in the majority of patients treated at the highest dose level of therapy with almost all patients having clinical benefit after tr
Florida State University researchers have new insight into the tiny packages that cells use to move molecules, a structure that is key to cellular metabolism, drug delivery and more.
A black swan event is a highly unlikely but massively consequential incident, such as the 2008 global recession and the loss of one-third of the world's saiga antelope in a matter of days in 2015. Challenging the quintessentially unpredictable nature of black swan events, bioengineers at Stanford University are suggesting a method for forecasting these supposedly unforeseeable fluctuations.
Headless Horseman Engineers in Japan have been hard at work building a gigantic, 60-foot humanoid robot modeled after those in the "Gundam" sci-fi franchise . And while construction of the robot has slowed due to the coronavirus, it seems like progress is well under way. A recent video shows it taking its first tentative steps, Popular Mechanics reports , despite still missing its head. The foota
A black swan event is a highly unlikely but massively consequential incident, such as the 2008 global recession and the loss of one-third of the world's saiga antelope in a matter of days in 2015. Challenging the quintessentially unpredictable nature of black swan events, bioengineers at Stanford University are suggesting a method for forecasting these supposedly unforeseeable fluctuations.
Frequency combs are becoming one of the great enabling technologies of the 21st century. High-precision atomic clocks, and high-precision spectroscopy are just two technologies that have benefited from the development of highly precise frequency combs. However, the original frequency comb sources required a room full of equipment. And it turns out that if you suggest that a room full of delicate e
NASA's Aqua satellite used infrared light to identify the strongest storms and coldest cloud top temperatures in Tropical Depression 8, spinning in the Gulf of Mexico.
Many Black men suffer symptoms of traumatic stress in the aftermath of traumatic injury, and they also often carry social concerns, including experiences of discrimination and stigma. Yet despite their significant needs, underserved populations often have limited access to behavioral health care as well as a lack of financial resources to pay for such care. Because of these barriers, many trauma s
Saturn is truly the lord of the rings in this latest snapshot from NASA's Hubble Space Telescope, taken on July 4, 2020, when the opulent giant world was 839 million miles from Earth. This new Saturn image was taken during summer in the planet's northern hemisphere.
Congress has passed sweeping legislation allocating $900 million a year for the Land and Water Conservation Fund (LWCF), and an additional $9.5 billion over five years to address an urgent backlog of maintenance projects at the nation's parks and other public lands.
There are many types of light—some visible and some invisible to the human eye. For example, our eyes and brain don't have the tools to process ultraviolet light when it hits our eyes, making it invisible. But there is another type of light that is invisible simply because it never reaches our eyes. When light hits certain surfaces, part of it sticks and remains behind rather than being transmitte
The new findings come after more than 10 years of observation. McLaughlin-Crater-Dunes.jpg McLaughlin Crater Dunes on Mars Image credits: NASA/JPL/University of Arizona Rights information: Public Domain Space Thursday, July 23, 2020 – 16:00 Christian Fogerty, Contributor (Inside Science) — Martian megaripples might sound like they are straight out of science fiction. But they are real and just
New genome-editing technologies developed by researchers in J. Keith Joung's laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes. The new base editors are also designed to minimize unintended ("off-target") mutations that could potentially cause undesirab
Highly stable polymeric "amyloid" proteins, best known for their role in Alzheimer's disease, have been mostly studied in animals. But a new study on the garden pea publishing July 23, 2020 in the open-access journal PLOS Biology, by Anton Nizhnikov of All-Russia Research Institute for Agricultural Microbiology (ARRIAM) and colleagues, shows that they also occur in plants, and they may be an impor
A new study examined data on lunar craters to gain a better understanding of ancient impact events on Earth. Although scientists know of some ancient impacts on Earth, weather and erosion makes it hard to study impacts that occurred beyond 600 million years ago. Studying craters on the moon can provide some clues. Since Earth formed 4.5 billion years ago, it's been bombarded by countless asteroid
Nerve cells have a special ion channel that has a key role in starting the electrical impulse that signals pain and is sent to the brain. New research finds that people who inherited the Neanderthal variant of this ion channel experience more pain.
When most people find that their actions have resulted in an undesirable outcome, they tend to rethink their decisions and ask, 'What should I have done differently to avoid this outcome?' When narcissists face the same situation, however, their refrain is, 'No one could have seen this coming!' In refusing to acknowledge that they have made a mistake, narcissists fail to learn from those mistakes,
A drone prototype that mimics the aerobatic manoeuvres of one of the world's fastest birds, the swift, is being developed by an international team of engineers in the latest example of biologically inspired flight.
New genome-editing technologies developed by researchers in J. Keith Joung's laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes. The new base editors are also designed to minimize unintended ("off-target") mutations that could potentially cause undesirab
Highly stable polymeric "amyloid" proteins, best known for their role in Alzheimer's disease, have been mostly studied in animals. But a new study on the garden pea publishing July 23, 2020 in the open-access journal PLOS Biology, by Anton Nizhnikov of All-Russia Research Institute for Agricultural Microbiology (ARRIAM) and colleagues, shows that they also occur in plants, and they may be an impor
Nature, Published online: 23 July 2020; doi:10.1038/d41586-020-02201-y Uncommon genetic variant dampens the response of uterine neurons that sense pain.
Nature, Published online: 23 July 2020; doi:10.1038/d41586-020-02198-4 The pandemic grounded many commercial flights, starving forecast models of valuable data acquired at high altitudes.
Even if we took every feasible action to reduce plastic pollution, we would only cut it by 78 per cent by 2040, a study has found. That doesn't mean we should stop trying
Earthquake monitoring stations have detected sharp reductions in Earth's surface vibrations during coronavirus lockdowns due to limits on noisy human activities
Smallpox DNA found in the bodies of people who lived in the Viking era show that these viruses were different to the one eliminated in the 20th century – and perhaps much less deadly
Some supposedly inert ingredients in common drugs — such as dyes and preservatives — may potentially be biologically active and could lead to unanticipated side effects, according to a preliminary new study by researchers from the UC San Francisco School of Pharmacy and the Novartis Institutes for BioMedical Research (NIBR).
One in 11 flowers carries disease-causing parasites known to contribute to bee declines, according to a Cornell University study that identifies how flowers act as hubs for transmitting diseases to bees and other pollinators.
Scientists have discovered extinct strains of smallpox in the teeth of Viking skeletons — proving for the first time that the killer disease plagued humanity for at least 1400 years.
Big Brain Elon Musk, who long been notorious for warning of the dangers of artificial intelligence, has a message to the doubters among us: They're not as clever as they think. In the past, Musk has gone as far as to say that artificial intelligence is even more dangerous than nuclear war, Business Insider reports . One of his concerns is that AI will replace human workers. But he also frets that
Nature has retracted a recent commentary after the author complained that he had been misled by the relationship of the publication to a financial sponsor and told to avoid critiquing work from the institution. The journal says it is revisiting its "editorial guidelines and processes" in the wake of the case. Kenneth Witwer, an RNA … Continue reading
Harvard researchers have developed a system to mold near-field light — opening the door to unprecedented control over this powerful, largely unexplored type of light.
In a new study, researchers from Texas A&M University and industry have designed a smart technology that can help utility companies better serve communities affected by blackouts. The researchers said their single device works by improving energy delivery between home solar-power systems and the electrical grid.
Online tools and assessments can help speed up diagnosis of autism spectrum disorder (ASD), the first comprehensive survey of research in the field has concluded. The survey showed that using internet-based tools in healthcare – a field known as telehealth – has potential to improve services in autism care, when used alongside existing methods. The results are timely as the Covid-19 pandemic is pr
Researchers have developed a new approach to compare changes in neural communication using electroencephalography and functional magnetic resonance imaging simultaneously. The approach allows them to assess the association between the two measurements and better understand neural connectivity changes over time.
This image, captured by the SPHERE instrument on ESO's Very Large Telescope, shows the star TYC 8998-760-1 accompanied by two giant exoplanets. This is the first time astronomers have directly observed more than one planet orbiting a star similar to the Sun. The image was captured by blocking the light from the young, Sun-like star (on the top left corner) using a coronagraph, which allows for th
When it comes to preventing the spread of COVID-19 , most of the focus in the media has been on wearing face masks and washing hands. And rightly so. However, with new cases being reported at an alarming rate all across the country, it's also incredibly important to regularly sterilize the things we touch the most, like our cell phones and keys. By doing so, it helps us from inadvertently bringin
Do you want to get the most out of a museum and encourage your child's interest in STEM? Try interacting with a teenaged museum docent. Research led by investigators from North Carolina State University and the University of Exeter in the U.K. has found that youth docents have an overall positive effect on visitors' experiences, learning and information retention at informal learning sites. The po
Researchers with an interest in unraveling gene regulation in human health and disease are expanding their horizons by closely looking at alternative polyadenylation (APA), an under-charted mechanism that regulates gene expression.
Bzz! It's mosquito season in Greenland. June and July marks the period when Arctic mosquitoes (Aedes nigripes) are in peak abundance, buzzing about the tundra. While Arctic mosquitoes serve as an important food source to other animals, they are notorious for their role as pests to humans and wildlife, including caribou, whose populations can be affected by their attacks. Yet, these mosquitoes spen
Researchers with an interest in unraveling gene regulation in human health and disease are expanding their horizons by closely looking at alternative polyadenylation (APA), an under-charted mechanism that regulates gene expression.
Bzz! It's mosquito season in Greenland. June and July marks the period when Arctic mosquitoes (Aedes nigripes) are in peak abundance, buzzing about the tundra. While Arctic mosquitoes serve as an important food source to other animals, they are notorious for their role as pests to humans and wildlife, including caribou, whose populations can be affected by their attacks. Yet, these mosquitoes spen
Throughout the world's oceans in global nutrient cycles, food chains, and climate, as well as increasingly in human-made industrial processes, a diverse set of planktonic microbes, such as algae, play an integral role. For nearly all of these planktonic microbes, however, little is known about them genetically beyond a few marker sequences, while their morphology, biological interactions, metaboli
The fatal disease smallpox is older and more widespread than scientists so far have proved. A new study by an international team of researchers from the University of Copenhagen and the University of Cambridge shows that the Vikings also suffered from smallpox.
Auriculella gagneorum, a small candy-striped snail from Oahu's Waianae Mountains, represents the first new species of a living Hawaiian land snail described in 60 years.
Throughout the world's oceans in global nutrient cycles, food chains, and climate, as well as increasingly in human-made industrial processes, a diverse set of planktonic microbes, such as algae, play an integral role. For nearly all of these planktonic microbes, however, little is known about them genetically beyond a few marker sequences, while their morphology, biological interactions, metaboli
Strange Metals For the first time, scientists are saying that so-called " strange metals " could be a bizarre new state of matter. According to new research published Wednesday in the journal PNAS by researchers at the Flatiron Institute and Cornell, there are even odd parallels between strange metals and black holes. Those unexpected similarities, they say, could help them probe previously unexp
Researchers combined avalanche physics with ecosystem data to create a computational method for predicting extreme ecological events. The method may also have applications in economics and politics.
The new base editing platform may help researchers understand and correct genetic diseases by selective editing of single DNA 'letters' across nucleobase classes.
The thalamus is a 'Grand Central Station' for sensory information coming to our brains. Almost every sight, sound, taste and touch travels to our brain's cortex via the thalamus. Researchers now report that the somatosensory part of the thalamic reticular nucleus is divided into two functionally distinct sub-circuits that have their own types of genetically defined neurons that are topographically
Fenway without fans cussing in the stands? Get used to it. (Veronica Benavides/Unsplash/) It's going to be a good while before fans can pack the bleachers and seats at sporting events again. But as teams mount their summer comebacks in empty arenas and stadiums, some leagues have found alternative ways to keep viewers from suffering awkward silences during the action. Here's what you can expect t
Buried underground near the Svalbard Global Seed Vault is the Arctic World Archive safeguarding humanity's books, documents, and data. The Archive includes the massive GitHub library of software code behind the world's open-source applications. Information in the vault is stored on special media said to be durable for 1,000 years. For a place that's so cold, Norway's Svalbard archipelago is downr
Meet PolyA-miner, a new computational tool that enables scientists to evaluate the contribution of alternative polyadenylation to gene regulation in health and disease.
Saturn is truly the lord of the rings in this latest snapshot from NASA's Hubble Space Telescope, taken on July 4, 2020, when the opulent giant world was 839 million miles from Earth. This new Saturn image was taken during summer in the planet's northern hemisphere.
A team of Brazilian and European scientists has determined the transmission rates and out-of-country origins of predominant SARS-CoV-2 strains currently circulating in Brazil, which harbors one of the fastest growing COVID-19 epidemics in the world.
A team of scientists has engineered the spike protein of the SARS-CoV-2 virus – a critical component of potential COVID-19 vaccines – to be more environmentally stable and generate larger yields in the lab.
A new modified version of the SARS-CoV-2 spike protein has a 10-fold higher expression rate in cell cultures than an earlier version that forms the basis of vaccine candidates currently in clinical trials from Moderna and Novavax. Vaccine manufacturers could swap in the new version and produce vaccine doses at much higher rates. Their findings appear today in Science.
A new study finds that youth docents have an overall positive effect on visitors' experiences, learning and information retention at informal learning sites — like museums. The positive effects accrued across age groups regardless of museum type, but were most apparent in children ages 9 to 11.
Scientists say the noise from boats and ships slows down the activity of baby fish on coral reefs, which leaves them more vulnerable to their predators.
New analysis by The Pew Charitable Trusts and SYSTEMIQ finds that without immediate and sustained action, the annual flow of plastic into the ocean could nearly triple by 2040. The study also identifies solutions that could cut this volume by more than 80% using technologies available today, if key decision-makers make system-wide changes. The findings were released in a report 'Breaking the Plast
The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new study published online in Science.
Removing carbon dioxide from power plant emissions is ever more urgent to limit the damage from climate change. UC Berkeley chemists working with ExxonMobil have come up with an efficient and less expensive technique for removing CO2 from natural gas plant emissions. The technique could be tweaked for more polluting plants that use coal. The chemists took a magnesium-based metal-organic framework
In a paper published July 23, 2020 in 'Science,' a multi-institution team discusses findings from an investigation of genetic mutations in seven species of North American stick insects (Timema) resulting in cryptic coloration.
Scientists have discovered extinct strains of smallpox in the teeth of Viking skeletons – proving for the first time that the killer disease plagued humanity for at least 1400 years. Smallpox spread via infectious droplets, killed around a third of sufferers and left another third permanently scarred or blind. Around 300 million people died from it in the 20th century alone before it was officiall
Viral DNA isolated from ancient human remains reveals the presence of smallpox in 7th century northern Europe, increasing the definitive antiquity of the disease in humans by nearly 1,000 years, according to a new study.
Immediate and globally coordinated action to limit plastic consumption and waste could reduce the rate of plastic pollution by nearly 80% over the next two decades, according to a new modeling report.
Global COVID-19 "lockdown" measures – the quarantines, physical isolation, travel restrictions and widespread closures of services and industry that countries around the world have implemented in 2020 – resulted in a months-long reduction in global seismic noise by up to 50%, representing the longest and most prominent global seismic noise reduction in recorded history.
Almost one billion tonnes of plastic will be dumped on land and in the oceans over the period from 2016 to 2040 unless the world acts, say a team of 17 global experts who have developed a computer model to track the stocks and flows of plastic around the world.
Researchers from Drexel University and the Korea Institute of Science and Technology have discovered a MXene material that presents exceptional electromagnetic interference shielding abilities.
Immune responses to influenza exposures increase early in life, then decline in middle age, according to a study published July 23 in the open-access journal PLOS Pathogens by Bingyi Yang of the University of Florida, Steven Riley of Imperial College London, Derek Cummings of the University of Florida, and colleagues.
Highly stable polymeric "amyloid" proteins, best known for their role in Alzheimer's disease, have been mostly studied in animals. But a new study on the garden pea publishing July 23, 2020 in the open-access journal PLOS Biology, by Anton Nizhnikov of All-Russia Research Institute for Agricultural Microbiology (ARRIAM) and colleagues, shows that they also occur in plants, and they may be an impor
When lockdown started in March, the world went instantly, strangely silent. City streets emptied. Joggers and families disappeared from parks. Construction projects froze. Stores closed. Now a network of seismic monitoring stations around the world has quantified this unprecedented period of quiet. The resulting research into "seismic silence," published in Science today, has shown just how much
Variola virus DNA found in bones of people from Denmark to Russia around Viking era The Vikings are known for their intrepid seafaring, fearsome fighting and extensive trading, but it seems it may not only have been goods and weapons they carried on their travels – they could also have carried a deadly disease. Researchers say they have found the world's earliest confirmed case of smallpox, revea
World must act now to protect wildlife in order to stop future virus crises, say scientists Coronavirus – latest updates See all our coronavirus coverage The cost of preventing further pandemics over the next decade by protecting wildlife and forests would equate to just 2% of the estimated financial damage caused by Covid-19, according to a new analysis. Two new viruses a year had spilled from t
Seismologists said high frequency noise fell as much as 50% as planes were grounded and roads emptied Coronavirus – latest updates See all our coronavirus coverage An unprecedented wave of silence spread around the world in the wake of the coronavirus pandemic, according to researchers who found that vibrations from human activity slumped under national lockdowns. Records from seismic stations al
No country has ever successfully sent a microphone to Mars. As a result, we've never heard the eerie sounds of the surface of Red Planet. "Even if only a few minutes of Martian sounds are recorded from this first experiment, the public interest will be high and the opportunity for scientific exploration real," famed astronomer Carl Sagan wrote in a 1996 letter to NASA, as quoted by the Planetary
Space War Last week, Russia tested what U.S. military officials believe to be a dangerous new anti-satellite weapon. In short, the Russian satellite Cosmos 2543 demonstrated that it's capable of approaching another satellite in orbit and shooting it down, C4ISRNET reports . And that demo, amidst international talks about demilitarizing space, has the Pentagon concerned . Nesting Dolls The actual
Natural gas has become the dominant source of electricity in the United States, and technologies capable of efficiently removing carbon dioxide (CO 2 ) from the flue emissions of natural gas–fired power plants could reduce their carbon intensity. However, given the low partial pressure of CO 2 in the flue stream, separation of CO 2 is particularly challenging. Taking inspiration from the crystal
Embryonic stem cells can propagate indefinitely in a pluripotent state, able to differentiate into all types of specialized cells when restored to the embryo. What sustains their pluripotency during propagation remains unclear. Here, we show that core pluripotency factors OCT4 and SOX2 suppress chaperone-mediated autophagy (CMA), a selective form of autophagy, until the initiation of differentiat
Excipients, considered "inactive ingredients," are a major component of formulated drugs and play key roles in their pharmacokinetics. Despite their pervasiveness, whether they are active on any targets has not been systematically explored. We computed the likelihood that approved excipients would bind to molecular targets. Testing in vitro revealed 25 excipient activities, ranging from low-nanom
The ongoing coronavirus disease 2019 (COVID-19) pandemic poses a severe threat to public health worldwide. We combine data on demography, contact patterns, disease severity, and health care capacity and quality to understand its impact and inform strategies for its control. Younger populations in lower-income countries may reduce overall risk, but limited health system capacity coupled with close
Hot carriers in plasmonic nanostructures, generated via plasmon decay, play key roles in applications such as photocatalysis and in photodetectors that circumvent bandgap limitations. However, direct experimental quantification of steady-state energy distributions of hot carriers in nanostructures has so far been lacking. We present transport measurements from single-molecule junctions, created b
Alloys that have high strengths at high temperatures are crucial for a variety of important industries including aerospace. Alloys with ordered superlattice structures are attractive for this purpose but generally suffer from poor ductility and rapid grain coarsening. We discovered that nanoscale disordered interfaces can effectively overcome these problems. Interfacial disordering is driven by m
A defining step in the biogenesis of a membrane protein is the insertion of its hydrophobic transmembrane helices into the lipid bilayer. The nine-subunit endoplasmic reticulum (ER) membrane protein complex (EMC) is a conserved co- and posttranslational insertase at the ER. We determined the structure of the human EMC in a lipid nanodisc to an overall resolution of 3.4 angstroms by cryo–electron
The electromagnetic near field enables subwavelength applications such as near-field microscopy and nanoparticle manipulation. Present methods to structure the near field rely on optical antenna theory, involving nanostructures that locally convert propagating waves into confined near-field patterns. We developed a theory of remote rather than local near-field shaping, based on cascaded mode conv
The rational design of enzymes is an important goal for both fundamental and practical reasons. Here, we describe a process to learn the constraints for specifying proteins purely from evolutionary sequence data, design and build libraries of synthetic genes, and test them for activity in vivo using a quantitative complementation assay. For chorismate mutase, a key enzyme in the biosynthesis of a
Lightweight, ultrathin, and flexible electromagnetic interference (EMI) shielding materials are needed to protect electronic circuits and portable telecommunication devices and to eliminate cross-talk between devices and device components. Here, we show that a two-dimensional (2D) transition metal carbonitride, Ti 3 CNT x MXene, with a moderate electrical conductivity, provides a higher shielding
The guanosine triphosphatase (GTPase) Rab32 coordinates a cell-intrinsic host defense mechanism that restricts the replication of intravacuolar pathogens such as Salmonella . Here, we show that this mechanism requires aconitate decarboxylase 1 (IRG1), which synthesizes itaconate, a metabolite with antimicrobial activity. We find that Rab32 interacts with IRG1 on Salmonella infection and facilitat
The Caribbean was one of the last regions of the Americas to be settled by humans, but where they came from and how and when they reached the islands remain unclear. We generated genome-wide data for 93 ancient Caribbean islanders dating between 3200 and 400 calibrated years before the present and found evidence of at least three separate dispersals into the region, including two early dispersals
The types of mutations affecting adaptation in the wild are only beginning to be understood. In particular, whether structural changes shape adaptation by suppressing recombination or by creating new mutations is unresolved. Here, we show that multiple linked but recombining loci underlie cryptic color morphs of Timema chumash stick insects. In a related species, these loci are found in a region
Cell size is fundamental to cell physiology. For example, cell size determines the spatial scale of organelles and intracellular transport and thereby affects biosynthesis. Although some genes that affect mammalian cell size have been identified, the molecular mechanisms through which cell growth drives cell division have remained elusive. We show that cell growth during the G 1 phase of the cell
The extensive heterogeneity of biological data poses challenges to analysis and interpretation. Construction of a large-scale mechanistic model of Escherichia coli enabled us to integrate and cross-evaluate a massive, heterogeneous dataset based on measurements reported by various groups over decades. We identified inconsistencies with functional consequences across the data, including that the t
Smallpox, one of the most devastating human diseases, killed between 300 million and 500 million people in the 20th century alone. We recovered viral sequences from 13 northern European individuals, including 11 dated to ~600–1050 CE, overlapping the Viking Age, and reconstructed near-complete variola virus genomes for four of them. The samples predate the earliest confirmed smallpox cases by ~10
There is some evidence that blood types can influence whether or not someone becomes infected with the coronavirus, as they do with SARS, but it is not yet conclusive
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Even with immediate action, 710 million metric tons of plastic will enter the environment in the next two decades, scientists show. Welcome to Plastic Planet.
The self-eating process in embryonic stem cells known as chaperone-mediated autophagy (CMA) and a related metabolite may serve as promising new therapeutic targets to repair or regenerate damaged cells and organs, Penn Medicine researchers show in a new study published online in Science.