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Sådan blev Den nye Lillebæltsbro bygget
Byggeriet havde taget fem et halvt år og kostet 265 mio. kr., da kong Frederik IX i oktober 1970 kunne indvi den nye forbindelse over Lillebælt. I denne artikel fortalte Tidsskrift for Ingeniør- og Bygningsvæsen udførligt om de tekniske aspekter ved brobyggeriet.
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UK Covid-19 survivors' plasma being trialled to treat critically ill
Blood plasma from recovered patients may hold antibodies produced to fight virus Coronavirus – latest updates See all our coronavirus coverage A trial has begun in the UK to test whether blood plasma from Covid-19 survivors could help treat those critically ill with the disease. Plasma is a clear liquid which makes up about half of people's blood volume and carries red and white blood cells and p
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One Death Is a Tragedy. 60,000 Deaths Are a Great Success.
"Nothing would be worse than declaring victory before the victory is won," President Trump said on March 29. It was a moment of clarity and wisdom, the sort of sober leadership the nation seeks from a president in times of crisis. And it was swiftly forgotten. A month later, Trump and his aides were ready to hang Mission Accomplished banners from the Eisenhower Executive Office Building. "The wor
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Cancel Rent
Donnette Leftord is facing some impossible math. A mother of three and the owner of a small housekeeping business, Leftord usually earns $408 a week. Her company has been closed during the coronavirus pandemic. The monthly rent on her apartment in Flatbush, Brooklyn, is $1,700. And her family has other expenses to pay too. "Medication is important to me. Food is important. Rent is important," Lef
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How To Use Your Phone to Declutter Your Life
Use your phone and your time in quarantine to declutter your life, and make some money.
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Covid-19 Is Killing Black People Unequally—Don't Be Surprised
The coronavirus pandemic is further exposing a gulf in the health statistics of white and black Americans that has existed for decades.
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11 Best Weekend Deals: Games, Phones, and Headphones
From a discount on the Google Pixel 3A to price cuts on videogames, we hope these deals will help stymie the stir-crazies.
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'No One Has Tested Us Before': EMTs Go Door-To-Door With Test Kits
EMTs are offering at-home coronavirus testing in at least four cities including New York City. The goal is to test people who might not seek it out on their own, and find people who need medical care. (Image credit: Seth Wenig/AP)
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Trump Tries to Be Normal
This week was notable for its lack of coronavirus briefings, which have held us in their grip for more than a month. Once a source of pride, they were exposing President Donald Trump, he discovered finally, as a figure of fun. In their place, the White House arranged a series of well-orchestrated events for him, away from the pressroom. The method suggested a discipline and sobriety unseen from t
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Shop Class, Over Zoom
Editor's Note: This story is the 16th in our series " On Teaching ," which aims to collect the wisdom and knowledge of veteran educators. As the coronavirus pandemic has forced the majority of American students to learn at home or remotely, we're asking some of the country's most experienced and accomplished teachers to share their advice and identify their students' most urgent needs. Wearing a
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A Strangely Comforting Quarantine Album
In March, as the coronavirus was bringing public life to a halt, John Darnielle of the Mountain Goats sat in his North Carolina home and composed music about fifth-century pagans on the verge of being annihilated by ascendant Christendom. One song, describing the furtive worship of old gods, included the phrase "Neck deep in our passions / Serve who we serve." He sat and thought about the next li
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Ugens debat: Den er gal med dampspærrerne
PLUS. En test har fundet huller i dampspærresystemer og tape, der ødelagde membranen over tid. Det førte til debat på ing.dk om bl.a. nytten af dampspærrer, alternativ isolering – og naturlovene.
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Italy's corporate reopening stirs fears over more deaths
Conflicting pressures between health and preventing economic ruin divide country as it emerges from lockdown
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Investment biker Jim Rogers desperate to hit the road
Renowned investor warns market correction is not over but there is value in commodities
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Coronavirus UK: how many confirmed cases are there in my area?
Latest figures from public health authorities on the spread of Covid-19 in the United Kingdom. Find out how many confirmed cases have been reported near you Coronavirus – live news updates Find all our coronavirus coverage here How to protect yourself from infection Please note: these are government figures on numbers of confirmed cases – some people who report symptoms are not being tested, and
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Antarctica vs. Science
For researchers using delicate, one-of-a-kind equipment, the extreme conditions at the bottom of the planet pose special challenges.
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The End of the Imperial Presidency
Democrats have long feared that in a national crisis, President Donald Trump would seize the chance to stretch his powers and sweep aside constitutional restraints. Yet as the pandemic rages, Trump may be creating an unanticipated legacy: By ceding some control to the states, he's allowing the nation's governors to reacquire executive muscle that has withered in the age of the imperial presidency
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No leadership and no plan: is Trump about to fail the US on coronavirus testing?
Declarations of false victory and a vacuum of federal leadership have undermined testing as experts warn reopening the US could result in disaster Coronavirus – live US updates Live global updates See all our coronavirus coverage A broad coalition of US health systems has mobilized to ramp up coronavirus testing in a national effort on a scale not seen since the second world war. But declarations
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Space exploration is the ultimate plan B. Here's why.
Space exploration is more than just the ultimate adventure, our study and investigation of space yields great scientific rewards, says astronaut Garrett Reisman. Earth is wonderful, but it won't last forever, so it's important that we maintain a big picture view to ensure the survival of the human species. Exploring space is our ticket to "the ultimate plan B," according to Reisman. If there were
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Homemade Mother's Day gifts Mom will love
Many moms would be delighted to receive a wine rack like this. (Jose Mendoza/) Mother's Day is coming up, and you're probably looking for a way to show Mom how much you appreciate her. Homemade gifts go a long way in that department, but if you're older than seven, you're going to have to do better than a macaroni "painting" of your family. Each of these five projects can come together easily in
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Coronavirus: US authorises use of anti-viral drug Remdesivir
The Food and Drug Administration authorises emergency use of the experimental anti-viral drug.
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Virus fra afføring hjælper mod fedme og diabetes, tyder ny forskning på
Transplantation af afføring bruges i dag til at behandle visse former for antibiotikaresistent diarré…
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How an unproven drug became a bellwether for global stocks
Investors have bet on Gilead's remdesivir as solution to coronavirus crisis
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Coronavirus 2 May: at a glance
A summary of the biggest developments in the global coronavirus outbreak Follow our latest coronavirus blog for live news and updates Key developments in the global coronavirus outbreak today include: Continue reading…
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IC3 kan få nyt liv som hybrid- eller eltog
PLUS. Ved at sætte strøm til det gennemprøvede IC3-tog kan det hjælpe med at elektrificere jernbanen –også uden køreledninger.
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Se kortet: Børn fra Lolland har fire gange større risiko for at dø end børn fra Frederiksberg
Børn af velstillede forældre har mindre risiko for at dø, viser nye tal.
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Found: Neural circuit that drives physical responses to emotional stress
Researchers at Nagoya University have discovered a neural circuit that drives physical responses to emotional stress. Emotional stress signals are processed in the "emotion" circuits and integrated in the DP/DTT. The integrated signals are transmitted to the hypothalamus which then drives a variety of physical responses through circuits that control "body" functions. The discovered "mind-body" con
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How to brand cultural products in overseas markets
Managers of cultural products should pay attention to both similarity and informativeness when translating titles, with the relative emphasis between the two decided based on the effect size and the feasibility of each strategy.
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Coronavirus World Updates: Live Tracker
The jump in cases comes as India prepares to ease some restrictions on movement next week. The Philippines has released almost 10,000 prisoners to slow the spread of infections.
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Ännu inget läkemedel mot svår PMS
Nu har resultatet kommit från en studie där 260 kvinnor har testat det första riktade läkemedlet mot svår PMS. Resultatet blev negativt eftersom placebo-effekten visade sig vara alldeles för stor.
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Central banks are storing up problems in fight to shield credit
Policymakers have eased stress in debt markets, but with long-lasting implications
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Tapirs Help Reforestation Via Defecation
The large herbivores appear to prefer disturbed areas over more intact ones, and spread many more seeds in those places through their droppings.
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Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity [Biochemistry]
Oxidation of cysteine thiols by physiological reactive oxygen species (ROS) initiates thermogenesis in brown and beige adipose tissues. Cellular selenocysteines, where sulfur is replaced with selenium, exhibit enhanced reactivity with ROS. Despite their critical roles in physiology, methods for broad and direct detection of proteogenic selenocysteines are limited. Here we…
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The structural basis of African swine fever virus pA104R binding to DNA and its inhibition by stilbene derivatives [Microbiology]
African swine fever virus (ASFV) is a highly contagious nucleocytoplasmic large DNA virus (NCLDV) that causes nearly 100% mortality in swine. The development of effective vaccines and drugs against this virus is urgently needed. pA104R, an ASFV-derived histone-like protein, shares sequence and functional similarity with bacterial HU/IHF family members and…
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Genome organization and interaction with capsid protein in a multipartite RNA virus [Biochemistry]
We report the asymmetric reconstruction of the single-stranded RNA (ssRNA) content in one of the three otherwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV). We exploit a sample consisting exclusively of particles with the same RNA content—specifically, RNAs 3 and 4—assembled in planta by agrobacterium-mediated transient…
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Distinct roles of stereociliary links in the nonlinear sound processing and noise resistance of cochlear outer hair cells [Neuroscience]
Outer hair cells (OHCs) play an essential role in hearing by acting as a nonlinear amplifier which helps the cochlea detect sounds with high sensitivity and accuracy. This nonlinear sound processing generates distortion products, which can be measured as distortion-product otoacoustic emissions (DPOAEs). The OHC stereocilia that respond to sound…
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Matrix-transmitted paratensile signaling enables myofibroblast-fibroblast cross talk in fibrosis expansion [Biophysics and Computational Biology]
While the concept of intercellular mechanical communication has been revealed, the mechanistic insights have been poorly evidenced in the context of myofibroblast–fibroblast interaction during fibrosis expansion. Here we report and systematically investigate the mechanical force-mediated myofibroblast–fibroblast cross talk via the fibrous matrix, which we termed paratensile signaling. Paratensile
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The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma [Neuroscience]
Glioblastoma (GBM) is the deadliest adult brain cancer, and all patients ultimately succumb to the disease. Radiation therapy (RT) provides survival benefit of 6 mo over surgery alone, but these results have not improved in decades. We report that radiation induces a glioma-initiating cell phenotype, and we have identified trifluoperazine…
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Increased variability but intact integration during visual navigation in Autism Spectrum Disorder [Psychological and Cognitive Sciences]
Autism Spectrum Disorder (ASD) is a common neurodevelopmental disturbance afflicting a variety of functions. The recent computational focus suggesting aberrant Bayesian inference in ASD has yielded promising but conflicting results in attempting to explain a wide variety of phenotypes by canonical computations. Here, we used a naturalistic visual path integration…
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Mapping mesoscale axonal projections in the mouse brain using a 3D convolutional network [Neuroscience]
The projection targets of a neuronal population are a key feature of its anatomical characteristics. Historically, tissue sectioning, confocal microscopy, and manual scoring of specific regions of interest have been used to generate coarse summaries of mesoscale projectomes. We present here TrailMap, a three-dimensional (3D) convolutional network for extracting axonal…
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Acoustofluidic sonoporation for gene delivery to human hematopoietic stem and progenitor cells [Engineering]
Advances in gene editing are leading to new medical interventions where patients' own cells are used for stem cell therapies and immunotherapies. One of the key limitations to translating these treatments to the clinic is the need for scalable technologies for engineering cells efficiently and safely. Toward this goal, microfluidic…
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Noise-driven cellular heterogeneity in circadian periodicity [Cell Biology]
Nongenetic cellular heterogeneity is associated with aging and disease. However, the origins of cell-to-cell variability are complex and the individual contributions of different factors to total phenotypic variance are still unclear. Here, we took advantage of clear phenotypic heterogeneity of circadian oscillations in clonal cell populations to investigate the underlying…
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Cavitation in lipid bilayers poses strict negative pressure stability limit in biological liquids [Physics]
Biological and technological processes that involve liquids under negative pressure are vulnerable to the formation of cavities. Maximal negative pressures found in plants are around −100 bar, even though cavitation in pure bulk water only occurs at much more negative pressures on the relevant timescales. Here, we investigate the influence…
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Modulations of foveal vision associated with microsaccade preparation [Psychological and Cognitive Sciences]
It is known that attention shifts prior to a saccade to start processing the saccade target before it lands in the foveola, the high-resolution region of the retina. Yet, once the target is foveated, microsaccades, tiny saccades maintaining the fixated object within the fovea, continue to occur. What is the…
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Paternal provisioning results from ecological change [Anthropology]
Paternal provisioning among humans is puzzling because it is rare among primates and absent in nonhuman apes and because emergent provisioning would have been subject to paternity theft. A provisioning "dad" loses fitness at the hands of nonprovisioning, mate-seeking "cads." Recent models require exacting interplay between male provisioning and female…
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Allosteric conformational change of a cyclic nucleotide-gated ion channel revealed by DEER spectroscopy [Biophysics and Computational Biology]
Cyclic nucleotide-gated (CNG) ion channels are essential components of mammalian visual and olfactory signal transduction. CNG channels open upon direct binding of cyclic nucleotides (cAMP and/or cGMP), but the allosteric mechanism by which this occurs is incompletely understood. Here, we employed double electron-electron resonance (DEER) spectroscopy to measure intersubunit distance…
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A unifying framework for the transient parasite dynamics of migratory hosts [Ecology]
Migrations allow animals to track seasonal changes in resources, find mates, and avoid harsh climates, but these regular, long-distance movements also have implications for parasite dynamics and animal health. Migratory animals have been dubbed "superspreaders" of infection, but migration can also reduce parasite burdens within host populations via migratory escape…
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Antiepileptic drugs induce subcritical dynamics in human cortical networks [Neuroscience]
Cortical network functioning critically depends on finely tuned interactions to afford neuronal activity propagation over long distances while avoiding runaway excitation. This importance is highlighted by the pathological consequences and impaired performance resulting from aberrant network excitability in psychiatric and neurological diseases, such as epilepsy. Theory and experiment suggest that
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Influence of spatially segregated IP3-producing pathways on spike generation and transmitter release in Purkinje cell axons [Neuroscience]
It has been known for a long time that inositol-trisphosphate (IP3) receptors are present in the axon of certain types of mammalian neurons, but their functional role has remained unexplored. Here we show that localized photolysis of IP3 induces spatially constrained calcium rises in Purkinje cell axons. Confocal immunohistology reveals…
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Accessories to boost your mobile gaming experience
Controllers, head phones, and more. (Screen Post via Unsplash/) The insidious nature of mobile gaming means that once you've found an app that suits your fancy you're probably well beyond hooked. Sure, you could do the noble thing and try to find a more "productive" hobby, but sometimes you just need to relax. For those times, we suggest a few pieces of gear that make playing on your cell phone a
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Tapirs Help Reforestation Via Defecation
The large herbivores appear to prefer disturbed areas over more intact ones, and spread many more seeds in those places through their droppings. — Read more on ScientificAmerican.com
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Judge Vacates Oil and Gas Leases on 145,000 Acres in Montana
A federal judge, rapping the Trump administration for its weak environmental assessments, has vacated hundreds of oil and gas leases across a large swath of Montana.
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