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The Atlantic Daily: A Playlist for Partying Alone
1dEvery weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox . When the coronavirus rolled in, our culture's many, many songs about hitting the town and hooking up started to seem infected, rather than just infectiously catchy . Others, though, became weirdl
Vietnam pulls out the stops to save 'Patient 91'
1dBritish pilot is on life support as officials race to find a lung transport donor
Court rules 'Dueling Dinos' belong to landowners, in a win for science
1dSpectacular fossils can't be legally considered minerals
'Doom Eternal' Will Drop Its Controversial Anti-Cheat Software
1dThe move comes just a week after the software was added to the game.
Doubts greet $1.2 billion bet by United States on a coronavirus vaccine by October
1dOperation Warp Speed's funding of AstraZeneca is intended to deliver a COVID-19 vaccine by October, although some call that timeline unrealistic.
Car rental group Hertz files for bankruptcy
1dUS-based group fails to meet a payment deadline agreed with its lenders
Canada v US: Loon stabs eagle through heart
1dThe loon, which is on Canada's dollar coin, and the eagle, America's national bird, fought to the death.
1d
MS risk 29% higher for people living in urban areas, new research reveals
1dThe research, due to be presented at the European Academy of Neurology (EAN) Virtual Congress, detected a reduced risk for MS in individuals residing in rural areas that have lower levels of air pollutants known as particulate matter (PM). It showed that the MS risk, adjusted for urbanisation and deprivation, was 29% higher among those residing in more urbanised areas.
Author Correction: Layered nanocomposites by shear-flow-induced alignment of nanosheets
1dNature, Published online: 23 May 2020; doi:10.1038/s41586-020-2372-z
People Are Still Terrible at Correctly Using Medical-Grade Face Masks And Respirators
2dA new study has some concerning results.
What Role Should Employers Play in Testing Workers?
2dAmazon and other companies are planning to test workers for the coronavirus. But there is little federal guidance, and some fear it could lead to a false sense of security.
CDC Says Coronavirus Does Not Spread Easily on Surfaces
2dIf you're worried about wiping down grocery bags or disinfecting mailed packages, this C.D.C. guidance might bring some relief. It's not new information; the agency has been saying this for months.
77 Nobel Laureates Denounce Trump Officials For Pulling Coronavirus Research Grant
2dIn a letter sent to Secretary of Health and Human Services Alex Azar, these U.S. scientists said they were "gravely concerned" about the abrupt termination of a federal grant to EcoHealth Alliance. (Image credit: NHPA/NHPA/Science Source)
Mississippi Delta marshes in a state of irreversible collapse
2dA key finding of the study is that coastal marshes experience tipping points, where a small increase in the rate of sea-level rise leads to widespread submergence.
Scientists identify a temperature tipping point for tropical forests
2dCarbon dioxide is an important greenhouse gas, released as fossil fuels are burned. It is absorbed by trees as they grow and stored as wood. When trees get too hot and dry, they may close the pores in their leaves to save water, but that also prevents them from taking in more carbon. And when trees die, they release stored carbon back into the atmosphere.
Why toothpaste and cement harden over time
2dCements, clays, soils, inks, paints, and even toothpaste. Many paste materials, also known as dense colloidal suspensions, stiffen as they age. Structural dynamics, or changes in the loads the materials undergo over time, are partly responsible for this change, but for decades, experts have suspected that there's more going on inside these materials. Now researchers have discovered a process calle
Now you can track vitamin C intake on your skin
2dA team at the University of California San Diego has developed a non-invasive skin patch that measures your vitamin C levels. An electrode sensor measures vitamin C in your sweat. The researchers hope this leads to the development of multivitamin patches that track nutritional deficiencies. Vitamin C has long been one of the most discussed and debated vitamins. The curative effects of citrus on s
A clue as to why it's so hard to wake up on a cold winter's morning
2dDo you remember the challenge of waking up on winter's cold, dark days? Neurobiologists have uncovered a clue to what's behind this behavior. In a study of the fruit fly, the researchers have identified a 'thermometer' circuit that relays information about external cold temperature from the fly antenna to the higher brain. They show how, through this circuit, seasonally cold and dark conditions ca
Why toothpaste and cement harden over time
2dCements, clays, soils, inks, paints, and even toothpaste. Many paste materials, also known as dense colloidal suspensions, stiffen as they age. Structural dynamics, or changes in the loads the materials undergo over time, are partly responsible for this change, but for decades, experts have suspected that there's more going on inside these materials. Now researchers have discovered a process calle
Glucose levels linked to maternal mortality even in non-diabetic women
2dAn elevated pre-pregnancy hemoglobin A1c — which measures average blood glucose concentration — is associated with a higher risk of adverse pregnancy outcomes even in women without known diabetes, according to a new study.
How the darter got stripes: Expanding a sexual selection theory explains animal patterns
2dScientists have shown for the first time that there is a strong correlation between the complex patterns on male darters and their highly-variable environments. The findings support and expand upon sensory drive theory, which states that the environment influences which sexual signals, like visual patterns, are selected for. Previous sensory drive research looked at simple signals (e.g. colors), b
Studies in monkeys show that coronavirus immunity holds up in vaccine treatments
2dLittle is known about how our immune systems respond to COVID-19, but studying how rhesus monkeys respond to the virus could help. (Pixabay/) Two new studies in monkeys offer more signs, though very preliminary, that humans may develop immunity after being vaccinated or recovering from COVID-19. Using a series of prototype vaccines—ones used for medical research only and not intended for human us
Yoga may ease symptoms of depression, according to new research
2dDepressive disorders are the leading cause of disability worldwide, affecting over 340 million people. According to a new study in the British Journal of Sports Medicine, yoga sessions may be able to ease depressive symptoms in people with mental health conditions such as depression, anxiety, and bipolar disorder. Mindfulness, meditation, and breathing control techniques are all things that have
Boom to bust in the US shale heartlands
2dFive charts that highlight the recent seizing up of the US oil sector
NASA gives go-ahead for first crewed SpaceX flight on May 27
2dNASA gave the green light on Friday to next week's launch of two astronauts aboard a SpaceX vessel—the first crewed space flight from US soil in nine years and a crucial step towards ending American dependence on Russian rockets.
Scientists solve half-century-old magnesium dimer mystery
2dMagnesium dimer (Mg2) is a fragile molecule consisting of two weakly interacting atoms held together by the laws of quantum mechanics. It has recently emerged as a potential probe for understanding fundamental phenomena at the intersection of chemistry and ultracold physics, but its use has been thwarted by a half-century-old enigma—five high-lying vibrational states that hold the key to understan
Mississippi Delta marshes in a state of irreversible collapse, study shows
2dGiven the present-day rate of global sea-level rise, remaining marshes in the Mississippi Delta are likely to drown, according to a new Tulane University study.
A stitch in time: How a quantum physicist invented new code from old tricks
2dBuilding large-scale quantum computers will require suppression of errors. Scientists have used a neat trick to apply powerful 3D error-suppression codes in a 2D architecture, something one industry insider said many thought was impossible.
Next-generation solar cells pass strict international tests
2dA cost-effective method to stabilise perovskite solar cells could soon see them become commercially viable.
Scientists identify chemicals in noxious weed that 'disarm' deadly bacteria
2dScientists have identified specific compounds from the Brazilian peppertree — a weedy, invasive shrub in Florida — that reduce the virulence of antibiotic-resistant staph bacteria. This research demonstrates that triterpenoid acids in the red berries of the plant "disarm" dangerous staph bacteria by blocking its ability to produce toxins.
Researchers boost microwave signal stability a hundredfold
2dResearchers have used state-of-the-art atomic clocks, advanced light detectors, and a measurement tool called a frequency comb to boost the stability of microwave signals 100-fold. This marks a giant step toward better electronics to enable more accurate time dissemination, improved navigation, more reliable communications and higher-resolution imaging for radar and astronomy.
The secret to succesful shiitake mushrooms? Electric shock treatment
2dJapanese farming folklore says lightning makes mushrooms multiply – and research shows there is truth in it A few years ago, I attempted to grow my own shiitake mushrooms. I purchased a special log, which had been seeded with mushroom spores, and followed the instructions to soak it and then keep it in a shady spot. Sadly no mushrooms ever fruited on my log, but maybe I would have had more luck i
Tropical forests can handle the heat, up to a point
2dTropical forests face an uncertain future under climate change, but new research suggests they can continue to store large amounts of carbon in a warmer world, if countries limit greenhouse gas emissions.
Implantable biosensor operates without batteries
2dResearchers have revealed their new biodegradable motion sensor — paving the way for implanted nanotechnology that could help future sports professionals better monitor their movements to aid rapid improvements, or help caregivers remotely monitor people living with dementia.
Blood pressure lowering reduces risk of developing dementia
2dResearch has shown that lowering blood pressure by taking blood pressure medications reduces the risk of developing dementia and cognitive impairment by 7%.
A 'switch' that turns autoimmunity drugs into powerful anti-cancer treatments
2dScientists have discovered a way to transform antibody drugs previously developed to treat autoimmunity into antibodies with powerful anti-cancer activity through a simple molecular 'switch'.
Sex bias in pain research
2dMost pain research remains overwhelmingly based on the study of male rodents, continuing to test hypotheses derived from earlier experiments on males. This points to an important blind spot in pain research, particularly as it relates to advancing research into new pain medications.
Coronavirus Vaccine Shows Promising Early Results in China
2dA trial with 108 participants suggests the vaccine is safe and may be moderately effective. But experts noted that the approach has failed in the past.
Sunak at odds with Johnson over speed of UK lockdown exit
2dChancellor takes aim at 'cautious' Sage experts amid Treasury alarm over economy
They redesigned PubMed, a beloved website. It hasn't gone over well
2dUnhappy researchers unleash torrent of complaints on social media
Pressure builds on Cummings to quit over alleged new lockdown breach
2dFresh claims that PM's adviser broke coronavirus measures emerged after ministers rallied in his support
New urine testing method holds promise for kidney stone sufferers
2dAn improved urine-testing system for people suffering from kidney stones inspired by nature may enable patients to receive results within 30 minutes instead of the current turnaround time of a week or more.
New mobile health tool measures hemoglobin without drawing blood
2dResearchers have developed a way to use smartphone images of a person's eyelids to assess blood hemoglobin levels. The ability to perform one of the most common clinical lab tests without a blood draw could help reduce the need for in-person clinic visits, make it easier to monitor patients who are in critical condition, and improve care in low- and middle-income countries where access to testing
Novel device harnesses shadows to generate electricity
2dResearchers have created a device called a 'shadow-effect energy generator' that makes use of the contrast in illumination between lit and shadowed areas to generate electricity. This novel concept opens up new approaches in harnessing indoor lighting conditions to power electronics.
Scientists find evidence of link between diesel exhaust, risk of Parkinson's
2dA new study in zebrafish identified the process by which air pollution can damage brain cells, potentially contributing to Parkinson's disease.
I spent over 40 years in the Australian defence force. Our lack of preparedness concerns me | Chris Barrie
2dIt is time Australian governments started to listen to experts when it comes to climate change and pandemics The past 18 years has been a period of significant disengagement and disinterest by the community in Australian political affairs. The political shenanigans described in Malcolm Turnbull's recent book A Bigger Picture ought to be a wake-up call that as our political leaders have jostled fo
Walking correctly takes work—here's how to improve every step
2dEach step happens in two parts. (Stan Horaczek/) Chances are, you learned to walk when you were just a toddler and you haven't really thought about it much since. It's easy to nerd out on other fitness activities, like running or weight lifting. But, walking is something we often take for granted. During the current pandemic, however, walking is having a moment. A simple stroll can go a long way
COVID-19 news from Annals of Internal Medicine
2d1. Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach; 2. Ventilation Techniques and Risk for Transmission of Coronavirus Disease, Including COVID-19: A Living Systematic Review of Multiple Streams of Evidence.
A clue as to why it's so hard to wake up on a cold winter's morning
2dDo you remember the challenge of waking up on winter's cold, dark days? Northwestern University neurobiologists have uncovered a clue to what's behind this behavior. In a study of the fruit fly, the researchers have identified a 'thermometer' circuit that relays information about external cold temperature from the fly antenna to the higher brain. They show how, through this circuit, seasonally col
The ins and outs of sex change in medaka fish
2dScientists could gain insight into atypical sex development in vertebrates, including humans, by studying how nutrition affects sex changes in fish larvae.
The self-synthesizing ribosome
2dAs the cell's protein factory, the ribosome is the only natural machine that manufactures its own parts. That is why understanding how the machine, itself, is made, could unlock the door to everything from understanding how life develops to designing new methods of drug production.
The self-synthesizing ribosome
2dAs the cell's protein factory, the ribosome is the only natural machine that manufactures its own parts. That is why understanding how the machine, itself, is made, could unlock the door to everything from understanding how life develops to designing new methods of drug production.
Large-scale analysis of protein arginine methylation by mass spectrometry
2dIn this research, the researchers offer an overview on state-of-the-art approaches for the high-confidence identification and accurate quantification of protein arginine methylation by high-resolution mass spectrometry methods, which comprise the development of both biochemical and bioinformatics methods.
Mississippi Delta marshes in a state of irreversible collapse, Tulane study shows
2dA key finding of the study, published in Science Advances, is that coastal marshes experience tipping points, where a small increase in the rate of sea-level rise leads to widespread submergence.
MSU scientists solve half-century-old magnesium dimer mystery
2dMagnesium dimer (Mg2) is a fragile molecule consisting of two weakly interacting atoms held together by the laws of quantum mechanics. It has recently emerged as a potential probe for understanding fundamental phenomena at the intersection of chemistry and ultracold physics, but its use has been thwarted by a half-century-old enigma — five high-lying vibrational states that hold the key to unders
Surging numbers of first-generation learners being left behind in global education
2d'First-generation learners' — a substantial number of pupils around the world who represent the first generation in their families to receive an education – are also significantly more likely to leave school without basic literacy or numeracy skills, a study suggests.
Unconscious: 'Sniff test' predicts recovery of consciousness
2dIf an unconscious person responds to smell through a slight change in their nasal airflow pattern — they are likely to regain consciousness. This is the conclusion from a new study.
New insight into allergies could improve diagnosis and treatment
2dResults from a new study may help to improve the diagnosis and treatment of allergies, pointing to a potential marker of these conditions and a new therapeutic strategy.
T-cells could be made into better cancer killers by increasing their protein production
2dResearchers have developed a technique to quantify protein production in immune cells known as T-cells, which typically target and kill cancer cells. However, when near a tumor, most T cells produce little protein and lose their cancer-fighting ability, and the new technique could help clarify why. Interventions could then be developed to restore protein production and allow T cells in the vicinit
Astronomers Detect Signal Coming From the Heart of Our Galaxy
2dFlare Up Scientists found something peculiar coming from the center of the Milky Way galaxy: a previously-undiscovered signal they think is coming from the supermassive black hole at the heart of our galaxy. The team of Keio University researchers think that the signal is caused when the accretion disk around the black hole flares up and give off extremely rapidly-rotating radio spots, according
Coronavirus antigen tests: quick and cheap, but too often wrong?
2dTests that detect coronavirus proteins raise hopes of widespread daily screening
Casey Removes Two Hooks from a Shark! | Deadliest Catch: Bloodline
2dCasey finds himself unhooking a shark in Hawaii after he accidentally snags one! Stream Full Episodes of Deadliest Catch: Bloodline: https://go.discovery.com/tv-shows/deadliest-catch-bloodline Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Join us on Facebook: https://www.facebook.com/DeadliestCatch https://www.facebook.com/Discovery Follow us on Twitter: https://twitter.com/DeadliestCa
AI maps forest dryness to better predict wildfires
2dA deep-learning model that maps forest dryness across 12 western states could pave the way for better wildfire predictions, researchers report. As California and the American West head into wildfire season amid the coronavirus pandemic, scientists are harnessing artificial intelligence and new satellite data to help predict wildfire blazes across the region. Anticipating where a fire is likely to
Coronavirus Roundup, May 16-May 22
2dPandemic news highlights for the week — Read more on ScientificAmerican.com
The Race For A Polio Vaccine Differed From The Quest To Prevent Coronavirus
2dIn the 1950s, as Dr. Jonas Salk and virologist Albert Sabin worked to create a vaccine to prevent infantile paralysis, the threat from polio was already long familiar to Americans. (Image credit: AP)
Google Pixel 3A Deal: WIRED's Favorite Android Phone Is Nearly Half Off
2dGoogle's affordable Pixel is still our favorite Android phone, and it's never been a better value.
'There are too many': bones of 60 mammoths found in Mexico
2dArchaeologists face surfeit of mammoths after bones found at airport under construction north of Mexico City Archaeologists have found the bones of about 60 mammoths at an airport under construction just north of Mexico City, near human-built "traps" where more than a dozen mammoths were found last year. Both discoveries reveal how appealing the area – once a shallow lake – was for the mammoths,
The Promise of Antibody Treatments for Covid-19
2dAs scientists race to create a vaccine, a parallel quest to engineer effective antibody treatments for the coronavirus is vital, too—and may provide relief sooner.
Coronavirus Roundup, May 16-May 22
2dPandemic news highlights for the week — Read more on ScientificAmerican.com
NASA Clears SpaceX Crew Dragon Mission for Liftoff
2dCleared for Liftoff NASA just gave SpaceX the go-ahead for its historic launch scheduled for May 27. The plan is to send NASA astronauts Bob Behnken and Doug Hurley to the International Space Station using the company's Crew Dragon capsule, lifted by a SpaceX Falcon 9 rocket. Liftoff is slated for 4:33 pm Eastern from NASA's Kennedy Space Center. Flight Readiness If successful — and the weather p
Elon Musk: Some of My Tweets "Were Definitely Extremely Dumb"
2dFor entrepreneur Elon Musk, it's been a strange couple of weeks leading up to what could be the first time a private space company launches humans to orbit . And now, mere days before his space company SpaceX is set to ferry two NASA astronauts to the ISS on board the company's Crew Dragon spacecraft, Musk took the time to reflect on the bizarre twists and turns in an interview with Bloomberg , n
Nasa SpaceX crew mission cleared to launch
2dA review panel finds no technical reason to delay the first US orbital crew launch in nine years.
Physics-defying ocean critter's 'propeller' caught on camera
2dResearchers have captured on video the physics-defying trick a tiny crustacean called Acartia uses to move through water. Walk along an Oregon beach and scoop up standing water left by the tide. Inside it you'll likely see tiny flecks moving at high speed. They probably are copepods, abundant aquatic crustaceans, barely two millimeters long, that are an integral part of the ocean's food web. Rese
All five of Earth's largest mass extinctions linked to global warming
2dThere have been five particularly large extinction events in Earth's history, and for the first time all of them have been linked to global warming
Covid-19: How do you calculate herd immunity? | podcast
2dHerd immunity represents the percentage of people in a population who need to be immune to a disease in order to protect those who aren't. Early on in the pandemic, researchers estimated the herd immunity threshold for Covid-19 to be 60%. Following a question from a listener, Ian Sample speaks to Rachel Thomas to explore the maths and find out exactly how herd immunity is calculated Continue read
Covid-19: How do you calculate herd immunity?
2dHerd immunity represents the percentage of people in a population who need to be immune to a disease in order to protect those who aren't. Early on in the pandemic, researchers estimated the herd immunity threshold for Covid-19 to be 60%. Following a question from a listener, Ian Sample speaks to Rachel Thomas to explore the maths and find out exactly how herd immunity is calculated. Help support
Migration patterns reveal an Eden for ancient humans and animals
2dResearchers have discovered a new migration pattern (or lack of) at Pinnacle Point, a now-submerged region in South Africa. While it was first believed large omnivores would travel to follow the growth of vegetation to survive, our researcher came to a completely new conclusion through studying antelope teeth! They discovered that this region was an Eden to all living species that called it home,
The coronavirus doesn't care about your long weekend plans
2dAs long as you practice safe social distancing, the outdoors is a low-risk way to spend your long weekend. (Pixabay/) Follow all of PopSci 's COVID-19 coverage here , including a glossary of oft-used terms , a list of sites with trustworthy medical advice , and tips on safe and healthy biking . It has been a frustrating couple of months to say the least. Social distancing has kept us stuck in our
Deutsche Bank asks top managers to waive one month's pay
2dSeveral hundred of the German lender's designated 'leaders' urged to take a voluntary cut
When developing vaccines against COVID-19, 'fast is slow, and slow is fast'
2dBypassing clinical trials for a potential SARS-CoV-2 vaccine would be "catastrophic," says Science Advances deputy editor Douglas Green in this Editorial. Instead, it's vital to take time to ensure any vaccine candidate's safety and investigate potential adverse
How a male fly knows when to make a move on a mate
2dLike people, fruit flies must decide when conditions are right to make a move on a mate. Males use age and odors to gauge their chances of success, but how they do that on a molecular level was a mystery. The answer lies, in part, in their DNA. Researchers find that the scent of other flies and internal hormones alter the activity of a gene that controls how turned on male flies are by pheromones.
A stitch in time: How a quantum physicist invented new code from old tricks
2dBuilding large-scale quantum computers will require suppression of errors. Dr Ben Brown at the University of Sydney has used a neat trick to apply powerful 3D error-suppression codes in a 2D architecture, something one industry insider said many thought was impossible.
New urine testing method holds promise for kidney stone sufferers
2dAn improved urine-testing system for people suffering from kidney stones inspired by nature and proposed by researchers from Penn State and Stanford University may enable patients to receive results within 30 minutes instead of the current turnaround time of a week or more.
Past is prologue: Genetic 'memory' of ancestral environments helps organisms readapt
2dOrganisms carry long-term 'memories' of their ancestral homelands that help them adapt to environmental change, according to a new study that involved raising chickens on the Tibetan Plateau and an adjacent lowland site.
Combinatorial screening approach opens path to better-quality joint cartilage
2dHigh-throughput platform identifies complex conditions with biomaterial compositions, and mechanical and chemical stimuli that help stem cells produce more robust cartilage.
Blood flow recovers faster than brain in micro strokes
2dWork by a Rice neurobiologist shows that increased blood flow to the brain is not an accurate indicator of neuronal recovery after a microscopic stroke.
Cell reproduction dogma challenged
2dMeiosis is essential to sexual reproduction. For almost 15 years, it has been commonly held that retinoic acid, a molecule derived from vitamin A, triggers meiosis in mammalian germ cells. Yet, in joint articles published in Science Advances, french researchers with their colleagues, demonstrate that meiosis in mice begins and proceeds normally even in the absence of retinoic acid. These findings
Researchers develop high-performance cancer vaccine using novel microcapsules
2dScientists from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have developed a new therapeutic tumor vaccine based on self-healing polylactic acid microcapsules, which can efficiently activate the immune system and inhibit tumor development.
Kids Aren't Spared From the Coronavirus. A New Inflammatory Condition in Children is on the Rise.
2dFevers, rashes, nausea and other less-visible symptoms point to the mysterious Multisystem Inflammatory Syndrome apparently related to the coronavirus.
SpaceX Gets Go-Ahead for NASA Astronaut Launch Next Week
2dThe agency confirmed its mission was proceeding smoothly, but made the announcement amid the puzzling departure of a top NASA official.
How Sweden wasted a 'rare opportunity' to study coronavirus in schools
2dOne of the few countries to keep primary schools open failed to collect data on children's role in pandemic
Researchers discover cell reproduction not triggered by retinoic acid as previously believed
2dMeiosis is essential to sexual reproduction. For almost 15 years, it has been commonly held that retinoic acid, a molecule derived from vitamin A, triggers meiosis in mammalian germ cells. Yet, in joint articles published in Science Advances, French researchers from the Institut de Biologie Valrose (CNRS / INSERM / Université Côte d'Azur) and the IGBMC (CNRS / INSERM / University of Strasbourg), w
Past is prologue: Genetic 'memory' of ancestral environments helps organisms readapt
2dOrganisms carry long-term "memories" of their ancestral homelands that help them adapt to environmental change, according to a new study that involved raising chickens on the Tibetan Plateau and an adjacent lowland site.
A stitch in time: How a quantum physicist invented new code from old tricks
2dA scientist at the University of Sydney has achieved what one quantum industry insider has described as "something that many researchers thought was impossible".
How a male fly knows when to make a move on a mate
2dMuch like people, fruit flies must decide when the time and place are right to make a move on a mate. Male fruit flies use cues such as age and pheromones to gauge their chances of success, but just how they do that on a molecular level was a mystery.
What Is Clubhouse, and Why Does Silicon Valley Care?
2dThe latest app du jour is a social network centered on talking—and it's building buzz with the oldest trick in the book.
Trump's favorite COVID-19 drug might actually increase risk of death
2dTrump Facebook May
This isn't the final word on the drug, but it looks like another nail in the coffin. (Unsplash/) Follow all of PopSci 's COVID-19 coverage here , including news on federal policies , the latest on immune-response research , and a state-by-state breakdown of confirmed cases . For weeks, hydroxychloroquine has been making headlines as a hotly contested therapy for treating patients with COVID-19. P
Researchers discover cell reproduction not triggered by retinoic acid as previously believed
2dMeiosis is essential to sexual reproduction. For almost 15 years, it has been commonly held that retinoic acid, a molecule derived from vitamin A, triggers meiosis in mammalian germ cells. Yet, in joint articles published in Science Advances, French researchers from the Institut de Biologie Valrose (CNRS / INSERM / Université Côte d'Azur) and the IGBMC (CNRS / INSERM / University of Strasbourg), w
Past is prologue: Genetic 'memory' of ancestral environments helps organisms readapt
2dOrganisms carry long-term "memories" of their ancestral homelands that help them adapt to environmental change, according to a new study that involved raising chickens on the Tibetan Plateau and an adjacent lowland site.
Independent scientists urge UK government to delay reopening schools
2dThe latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
Coronavirus Live Updates: Trump Calls Houses of Worship 'Essential Services' and Urges Reopening
2dA federal agency and several state health departments have come under fire for mixing two types of virus tests. Many Memorial Day events will look different. A new study found that hydroxychloroquine, promoted by President Trump, may be harmful when taken to treat the virus.
Live Coronavirus Updates: U.K., Vaccine, China
2dImmunizations are falling because of pandemic disruptions, raising fears of surges in preventable disease. Lockdowns complicate the Muslim holiday Eid. China's National People's Congress offers a show of strength.
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation
2dInflammation is an essential part of immunity against pathogens and tumors but can promote disease if not tightly regulated. Self and non-self-nucleic acids can trigger inflammation, through recognition by the cyclic GMP-AMP (cGAMP) synthetase (cGAS) and subsequent activation of the stimulator of interferon genes (STING) protein. Here, we show that RNA:DNA hybrids can be detected by cGAS and that
A fault-tolerant non-Clifford gate for the surface code in two dimensions
2dFault-tolerant logic gates will consume a large proportion of the resources of a two-dimensional quantum computing architecture. Here we show how to perform a fault-tolerant non-Clifford gate with the surface code; a quantum error-correcting code now under intensive development. This alleviates the need for distillation or higher-dimensional components to complete a universal gate set. The operat
Supercooled liquid sulfur maintained in three-dimensional current collector for high-performance Li-S batteries
2dIn lithium-sulfur (Li-S) chemistry, the electrically/ionically insulating nature of sulfur and Li 2 S leads to sluggish electron/ion transfer kinetics for sulfur species conversion. Sulfur and Li 2 S are recognized as solid at room temperature, and solid-liquid phase transitions are the limiting steps in Li-S batteries. Here, we visualize the distinct sulfur growth behaviors on Al, carbon, Ni cur
Self-healing microcapsules synergetically modulate immunization microenvironments for potent cancer vaccination
2dTherapeutic cancer vaccines that harness the immune system to reject cancer cells have shown great promise for cancer treatment. Although a wave of efforts have spurred to improve the therapeutic effect, unfavorable immunization microenvironment along with a complicated preparation process and frequent vaccinations substantially compromise the performance. Here, we report a novel microcapsule-bas
Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships
2dImine reductases (IREDs) have shown great potential as catalysts for the asymmetric synthesis of industrially relevant chiral amines, but a limited understanding of sequence activity relationships makes rational engineering challenging. Here, we describe the characterization of 80 putative and 15 previously described IREDs across 10 different transformations and confirm that reductive amination c
Meiosis occurs normally in the fetal ovary of mice lacking all retinoic acid receptors
2dGametes are generated through a specialized cell differentiation process, meiosis, which, in ovaries of most mammals, is initiated during fetal life. All- trans retinoic acid (ATRA) is considered as the molecular signal triggering meiosis initiation. In the present study, we analyzed female fetuses ubiquitously lacking all ATRA nuclear receptors (RAR), obtained through a tamoxifen-inducible cre r
Avalanches and power law behavior in aortic dissection propagation
2dAortic dissection is a devastating cardiovascular disease known for its rapid propagation and high morbidity and mortality. The mechanisms underlying the propagation of aortic dissection are not well understood. Our study reports the discovery of avalanche-like failure of the aorta during dissection propagation that results from the local buildup of strain energy followed by a cascade failure of
Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary
2dIn mammals, the timing of meiosis entry is regulated by signals from the gonadal environment. All- trans retinoic acid (ATRA) signaling is considered the key pathway that promotes Stra8 ( stimulated by retinoic acid 8 ) expression and, in turn, meiosis entry. This model, however, is debated because it is based on analyzing the effects of exogenous ATRA on ex vivo gonadal cultures, which not accur
Possibility of realizing superionic ice VII in external electric fields of planetary bodies
2dIn a superionic (SI) ice phase, oxygen atoms remain crystallographically ordered while protons become fully diffusive as a result of intramolecular dissociation. Ice VII's importance as a potential candidate for a SI ice phase has been conjectured from anomalous proton diffusivity data. Theoretical studies indicate possible SI prevalence in large-planet mantles (e.g., Uranus and Neptune) and exop
Direct observation of a coil-to-helix contraction triggered by vinculin binding to talin
2dVinculin binds unfolded talin domains in focal adhesions, which recruits actin filaments to reinforce the mechanical coupling of this organelle. However, it remains unknown how this interaction is regulated and its impact on the force transmission properties of this mechanotransduction pathway. Here, we use magnetic tweezers to measure the interaction between vinculin head and the talin R3 domain
All major cholesterol-dependent cytolysins use glycans as cellular receptors
2dCholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all eight major CDCs have high-affinity lectin activity that identifies glycans as candidate cellular receptors. Streptolysin O, vaginolysin, and perfringolysin O bind multiple glycans, while pneumolysin, lectinolysin, a
Tipping points of Mississippi Delta marshes due to accelerated sea-level rise
2dCoastal marshes are threatened by relative sea-level (RSL) rise, yet recent studies predict marsh survival even under the high rates of RSL rise expected later in this century. However, because these studies are mostly based on short-term records, uncertainty persists about the longer-term vulnerability of coastal marshes. We present an 8500-year-long marsh record from the Mississippi Delta, show
Combinatorial screening of biochemical and physical signals for phenotypic regulation of stem cell-based cartilage tissue engineering
2dDespite great progress in biomaterial design strategies for replacing damaged articular cartilage, prevention of stem cell-derived chondrocyte hypertrophy and resulting inferior tissue formation is still a critical challenge. Here, by using engineered biomaterials and a high-throughput system for screening of combinatorial cues in cartilage microenvironments, we demonstrate that biomaterial cross
Vibration-induced boundary-layer destabilization achieves massive heat-transport enhancement
2dThermal turbulence is well known as a potent means to convey heat across space by a moving fluid. The existence of the boundary layers near the plates, however, bottlenecks its heat-exchange capability. Here, we conceptualize a mechanism of thermal vibrational turbulence that breaks through the boundary-layer limitation and achieves massive heat-transport enhancement. When horizontal vibration is
Interfacing gene circuits with microelectronics through engineered population dynamics
2dWhile there has been impressive progress connecting bacterial behavior with electrodes, an attractive observation to facilitate advances in synthetic biology is that the growth of a bacterial colony can be determined from impedance changes over time. Here, we interface synthetic biology with microelectronics through engineered population dynamics that regulate the accumulation of charged metaboli
Efficient blockade of locally reciprocated tumor-macrophage signaling using a TAM-avid nanotherapy
2dInterpreting how multicellular interactions in the tumor affect resistance pathways to BRAF and MEK1/2 MAPK inhibitors (MAPKi) remains a challenge. To investigate this, we profiled global ligand-receptor interactions among tumor and stromal/immune cells from biopsies of MAPK-driven disease. MAPKi increased tumor-associated macrophages (TAMs) in some patients, which correlated with poor clinical r
Phenotypic plasticity as a long-term memory easing readaptations to ancestral environments
2dPhenotypic plasticity refers to environment-induced phenotypic changes without mutation and is present in all organisms. The role of phenotypic plasticity in organismal adaptations to novel environments has attracted much attention, but its role in readaptations to ancestral environments is understudied. To address this question, we use the reciprocal transplant approach to investigate the multit
Roadmap for advanced aqueous batteries: From design of materials to applications
2dSafety concerns about organic media-based batteries are the key public arguments against their widespread usage. Aqueous batteries (ABs), based on water which is environmentally benign, provide a promising alternative for safe, cost-effective, and scalable energy storage, with high power density and tolerance against mishandling. Research interests and achievements in ABs have surged globally in
In situ repair abilities of human umbilical cord-derived mesenchymal stem cells and autocrosslinked hyaluronic acid gel complex in rhesus monkeys with intrauterine adhesion
2dIncreasing occurrence of moderate to severe intrauterine adhesion (IUA) is seriously affecting the quality of human life. The aim of the study was to establish IUA models in nonhuman primates and to explore the dual repair effects of human umbilical cord–derived mesenchymal stem cells (huMSCs) loaded on autocrosslinked hyaluronic acid gel (HA-GEL) on endometrial damage and adhesion. Here, we reco
Chromatin-based reprogramming of a courtship regulator by concurrent pheromone perception and hormone signaling
2dTo increase fitness, animals use both internal and external states to coordinate reproductive behaviors. The molecular mechanisms underlying this coordination remain unknown. Here, we focused on pheromone-sensing Drosophila Or47b neurons, which exhibit age- and social experience–dependent increase in pheromone responses and courtship advantage in males. Fruitless M (Fru M ), a master regulator of
Observation of generalized Kibble-Zurek mechanism across a first-order quantum phase transition in a spinor condensate
2dThe Kibble-Zurek mechanism provides a unified theory to describe the universal scaling laws in the dynamics when a system is driven through a second-order quantum phase transition. However, for first-order quantum phase transitions, the Kibble-Zurek mechanism is usually not applicable. Here, we experimentally demonstrate and theoretically analyze a power-law scaling in the dynamics of a spin-1 co
SLIPS-LAB–A bioinspired bioanalysis system for metabolic evaluation of urinary stone disease
2dUrinary stone disease is among the most common medical conditions. Standard evaluation of urinary stone disease involves a metabolic workup of stone formers based on measurement of minerals and solutes excreted in 24-hour urine samples. Nevertheless, 24-hour urine testing is slow, expensive, and inconvenient for patients, which has hindered widespread adoption in clinical practice. Here, we demon
Volcanic-induced global monsoon drying modulated by diverse El Nino responses
2dThere remains large intersimulation spread in the hydrologic responses to tropical volcanic eruptions, and identifying the sources of diverse responses has important implications for assessing the side effects of solar geoengineering and improving decadal predictions. Here, we show that the intersimulation spread in the global monsoon drying response strongly relates to diverse El Niño responses
Multimodal mapping of neural activity and cerebral blood flow reveals long-lasting neurovascular dissociations after small-scale strokes
2dNeurovascular coupling, the close spatial and temporal relationship between neural activity and hemodynamics, is disrupted in pathological brain states. To understand the altered neurovascular relationship in brain disorders, longitudinal, simultaneous mapping of neural activity and hemodynamics is critical yet challenging to achieve. Here, we use a multimodal neural platform in a mouse model of
Significantly enhancing production of trans-4-hydroxy-L-proline by integrated system engineering in Escherichia coli
2dTrans- 4-hydroxy–proline is produced by trans -proline-4-hydroxylase with -proline through glucose fermentation. Here, we designed a thorough "from A to Z" strategy to significantly improve trans -4-hydroxy–proline production. Through rare codon selected evolution, Escherichia coli M1 produced 18.2 g L –1 -proline. Metabolically engineered M6 with the deletion of putA , proP , putP , and aceA ,
| Free to read: Scientists vs politicians: the reality check for 'warp speed' vaccine research
2dHollywood-style messages from politicians about beating the pandemic downplay the technical complexity
How a male fly knows when to make a move on a mate
2dMuch like people, fruit flies must decide when the time and place are right to make a move on a mate. Male fruit flies use cues such as age and pheromones to gauge their chances of success, but just how they do that on a molecular level was a mystery.
The antimalarial drug Trump took for covid might actually be dangerous
2dChloroquine and hydroxychloroquine are two of the most hyped drugs being studied as treatments for covid-19 , thanks in large part to President Donald Trump's repeated promotion during his public appearances. Trump told reporters this week he had been taking hydroxychloroquine as a preventive measure. But a new study published Friday in The Lancet suggests not just that the drugs don't offer any
Large Study: Hydroxychloroquine Linked to Increased Death Risk
2dAccording to a new study of 96,000 hospitalized COVID-19 patients from around the world, the antimalarial drug hydroxychloroquine is linked to an increased risk of serious heart rhythm complications that can end in death. The news, strikingly, comes days after U.S. president Donald Trump told reporters he is taking the drug, noting that he gets "a lot of positive calls about it," as quoted by the
Covid-19 forces the pace of business change
2dBig Tech groups the biggest beneficiaries of disruption to working practices
Coronapod: Hope and caution greet vaccine trial results
2dNature, Published online: 22 May 2020; doi:10.1038/d41586-020-01557-5 The first results from vaccine trials are promising, but scientists still urge caution, and Trump issues an ultimatum to the WHO.
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