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How a victory for a small bog could herald a new era for conservation
Against the odds, a tiny wildlife retreat has won the day in a battle with developers. It is a sign that attitudes may finally be changing for the better, says Graham Lawton
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Versatile and stylish kegerators for your home
Keep it flowing. (Bence Boros via Unsplash/) The concept of an "essential" home appliance is sometimes objective. It may be difficult to convince some that a personal beer tap is one of those can't-live-without things, so you may have to get creative with your sales pitch. Luckily, whether you're a hardcore home brew enthusiast or just someone who needs the kegerator do contribute something—anyth
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The Advantage of a Biden Shadow Cabinet
Joe Biden beat a rival in the Democratic primary whose slogan was "Not me, us." Now a growing number of Democrats believe that Biden should adopt Bernie Sanders's rallying cry for himself—with a twist. For Sanders, "Not me, us" conveyed that he viewed himself as the voice and vessel of a mass movement. That's not a realistic aspiration for Biden, but the slogan could symbolize a compelling altern
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Cyclones can damage even distant reefs
Big and strong cyclones can harm coral reefs as far as 1000 kilometers away from their paths, new research shows. A new study sounds a warning about the way strong cyclone winds build extreme seas that affect coral reefs in Australia and around the world.
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Researchers explore potential treatment for mitochondrial diseases
Huntington's. Parkinson's. Muscular dystrophy. Lou Gehrig's. These diseases share a common cause that devastatingly robs sufferers of their energy, muscle control, and in the case of Huntington's, their sanity. But now, a group of researchers from UConn describes how a possible therapy might work.
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Researchers study videogame use patterns and the differences in gender among adolescents
Adolescents spend an average 47 minutes a day playing videogames, although boys spend more time playing, especially on weekends, and invest more money in this type of entertainment compared to girls, who are mainly occasional players. These are some of the main results of the study on videogame use patterns among teenage boys and girls in the Valencian Community, conducted by Education Science Dep
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Researchers explore potential treatment for mitochondrial diseases
Huntington's. Parkinson's. Muscular dystrophy. Lou Gehrig's. These diseases share a common cause that devastatingly robs sufferers of their energy, muscle control, and in the case of Huntington's, their sanity. But now, a group of researchers from UConn describes how a possible therapy might work.
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How the U.S. Fought the 1957 Flu Pandemic
The story of the medical researcher whose quick action protected millions of Americans from a new contagion
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Fibernet tæt på at overhale kobbernettet
PLUS. Internetforbindelsen i de danske hjem kommer i stigende grad fra fibernet, mens kobber bliver udfaset. Corona-krisen ser ud til at sætte ekstra turbo på teknologiskiftet.
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Are you ready for this summer's cicada invasion?
After 17 years underground, cicadas will make their return in 2020—amassing in the millions in parks, woods, and other outdoor spaces. While the numbers might seem alarming, never fear. The critters may prove a nuisance, but they're actually harmless, says Gary Parsons , an entomologist at Michigan State University. Here, Parsons digs into the life of a cicada, how they navigate their surfacing,
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Buildings Consume Lots of Energy—Here's How to Design Whole Communities That Give Back as Much as They Take
Although the coronavirus pandemic has dominated recent headlines, climate change hasn't gone away . Many experts are calling for a " green" economic recovery that directs investments into low-carbon energy sources and technologies . Buildings account for 40 percent of total energy consumption in the US , compared to 32 percent for industry and 28 percent for transportation. States and cities with
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New technique offers higher resolution molecular imaging and analysis
A new approach could help researchers understand more complicated biomolecular interactions and characterize cells and diseases at the single-molecule level.
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The death marker protein cleans up your muscles after exercise
Researchers have demonstrated that physical activity prompts a clean-up of muscles as the protein ubiquitin tags onto worn-out proteins, causing them to be degraded. This prevents the accumulation of damaged proteins and helps keep muscles healthy.
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Human growth hormone treatment after ACL injury may prevent loss of muscle strength
A new study finds the use of HGH treatment in patients that have undergone ACL reconstructive surgery may prevent the loss of muscle strength and weakness.
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Exchange of arms between chromosomes using molecular scissors
The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants. Research teams have now not only exchanged single genes, but recombined entire chromosomes with the CRISPR/Cas technology. In this way, desired properties can be combined in crops.
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World's oldest bug is fossil millipede from Scotland
A 425-million-year-old millipede fossil from the Scottish island of Kerrera is the world's oldest 'bug' — older than any known fossil of an insect, arachnid or other related creepy-crawly, according to researchers at The University of Texas at Austin.
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MdSUT4.1 participates in regulation of fruit sugar accumulation in apples
Apples are an economically important fruit crop worldwide. Sugar content is an essential component of fruit organoleptic quality, especially fruit sweetness, and thus is given a high priority in apple breeding programs. However, details on the complex molecular mechanism underlying fruit sugar accumulation remain scarce.
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MdSUT4.1 participates in regulation of fruit sugar accumulation in apples
Apples are an economically important fruit crop worldwide. Sugar content is an essential component of fruit organoleptic quality, especially fruit sweetness, and thus is given a high priority in apple breeding programs. However, details on the complex molecular mechanism underlying fruit sugar accumulation remain scarce.
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Why you may need to encourage social distancing around your bird feeder
People in Britain feed up to 196 million birds a year with 60,000 tonnes of bird food, at a total cost of £300 million. All those garden feeders have helped boost populations of dozens of bird species, including the garden regular, the blue tit, whose numbers have increased by 26% in the last 50 years.
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Why you may need to encourage social distancing around your bird feeder
People in Britain feed up to 196 million birds a year with 60,000 tonnes of bird food, at a total cost of £300 million. All those garden feeders have helped boost populations of dozens of bird species, including the garden regular, the blue tit, whose numbers have increased by 26% in the last 50 years.
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Regionsrådsformand afviser problemer med ytringsfrihed
Bekymring for ytringsfrihed blandt ansatte i Region Midtjylland udspringer primært af pressens beskrivelser, og er ikke reelle, mener regionsrådsformand i Region Midtjylland Anders Kühnau.
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Tiny, self-assembling traps capture dangerous pollutants, PFAS
A study shows that self-assembling molecular traps can be used to capture PFAS — dangerous pollutants that have contaminated drinking water supplies around the world.
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Johnson stops advisers commenting on Cummings' lockdown trips
UK prime minister says it would be wrong for chief scientific and medical officers to discuss 'political' matter
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How the super rich conquered London
Over cups of tea in his ramshackle London home I chatted with a novelist. It felt a valuable opportunity, given his multiple fictional treatments of London, to discuss the city's rapid changes that I was also writing about.
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Small-scale mining for gold has produced long-lasting toxic pollution, from 1860s California to modern Peru
Gold is everywhere in modern life, from jewelry to electronics to smartphones. The global electronics industry alone uses 280 tons annually. And that demand keeps growing.
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Tiny, self-assembling traps capture dangerous pollutants, PFAS
A study shows that self-assembling molecular traps can be used to capture PFAS — dangerous pollutants that have contaminated drinking water supplies around the world.
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A potential explanation for urban smog
The effect of nitric acid on aerosol particles in the atmosphere may offer an explanation for the smog seen engulfing cities on frosty days.
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Erosion of ozone layer responsible for mass extinction event
Researchers have shown that an extinction event 360 million years ago, that killed much of the Earth's plant and freshwater aquatic life, was caused by a brief breakdown of the ozone layer that shields the Earth from damaging ultraviolet (UV) radiation. This is a newly discovered extinction mechanism with profound implications for our warming world today.
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SUTD developed a simple method to print planar microstructures of polysiloxane
SUTD developed the embedded ink writing (EIW) method, enabling the direct writing of polysiloxane which helps in the fabrication of microfluidic devices, flexible wearables, and soft actuators.
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New technique offers higher resolution molecular imaging and analysis
The new approach from Northwestern Engineering could help researchers understand more complicated biomolecular interactions and characterize cells and diseases at the single-molecule level.
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Researchers flag similarities between COVID-19 deaths and severe rheumatic illnesses
Rheumatologists at the University of Alberta are flagging similarities between the deaths of some COVID-19 patients and those with rheumatic illnesses, and are testing proven rheumatic treatments to see whether they help against the pandemic virus.
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PKU-led team found effective SARS-CoV-2 neutralizing antibodies
A joint research team led by Sunney Xie, Director of Beijing Advanced Innovation Center for Genomics (ICG) at Peking University (PKU) has identified multiple highly potent neutralizing antibodies against the novel coronavirus SARS-CoV-2, the causative virus of the respiratory disease COVID-19.
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Varm luft som svar på medarbejdernes bekymringsbrev
Der eksisterer et usundt og ødelæggende samarbejdsmiljø i Region Midt. Hvis regionsrådsformanden vil bevare en lille del af sin troværdighed, skal han komme ud af sit flyverskjul, skriver overlægerådsformand Henning Glerup på vegne af de 220 underskrivere af bekymringsbrev.
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Gap between rich, poor neighborhoods growing in some cities
New research provides insight into how housing prices and neighborhood values have become polarized in some urban areas, with the rich getting richer and the poor becoming poorer.
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Parents, especially mothers, paying heavy price for lockdown
School closures, massive rates of job loss and furloughing, and a shift to working from home are all affecting how parents spend their time, and how mothers and fathers divide responsibilities for paid work, housework and childcare, finds a new study co-led by UCL.
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Topology control of human fibroblast cells monolayer by liquid crystal elastomer
Eukaryotic cells within living tissues can affect important physiological processes such as apoptosis and cell migration based on dynamic pattern formation with spatially varying orientations. However, it is yet challenging to project a predesigned map of orientational order onto a growing tissue in the lab. In a new study now published on Science Advances, Taras Turiv and a research team in chemi
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Topology control of human fibroblast cells monolayer by liquid crystal elastomer
Eukaryotic cells within living tissues can affect important physiological processes such as apoptosis and cell migration based on dynamic pattern formation with spatially varying orientations. However, it is yet challenging to project a predesigned map of orientational order onto a growing tissue in the lab. In a new study now published on Science Advances, Taras Turiv and a research team in chemi
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AI lets robotic prosthetics 'see' uncertain terrain
New software that can be integrated with existing hardware to enable people using robotic prosthetics or exoskeletons to walk in a safer, more natural manner on different types of terrain, researchers report. The new framework incorporates computer vision into prosthetic leg control, and includes robust artificial intelligence (AI) algorithms that allow the software to better account for uncertai
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Well begun is half done? Researchers study the recipe for efficient protein synthesis
Skoltech scientists and their colleagues have studied more than 30 thousand variants of genetic sequences encoding two fluorescent proteins in order to determine which characteristics of mRNA and of the first dozen or so codons in it can increase the efficiency of translation. Among other things, they found that rare codons at the beginning of the sequence do not seem to enhance translation, contr
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Well begun is half done? Researchers study the recipe for efficient protein synthesis
Skoltech scientists and their colleagues have studied more than 30 thousand variants of genetic sequences encoding two fluorescent proteins in order to determine which characteristics of mRNA and of the first dozen or so codons in it can increase the efficiency of translation. Among other things, they found that rare codons at the beginning of the sequence do not seem to enhance translation, contr
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New clues to deep earthquake mystery
A new understanding of our planet's deepest earthquakes could help unravel one of the most mysterious geophysical processes on Earth.
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Exploring the use of 'stretchable' words in social media
An investigation of Twitter messages reveals new insights and tools for studying how people use stretched words, such as 'duuuuude,' 'heyyyyy,' or 'noooooooo.'
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Cincinnati children's HLH research points to treatment for COVID-19 cytokine storms
A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic. One of the genetically engineered mouse strain's inventors–Cincinnati Children's cancer pathologist Gang Huang, PhD– is co-investigator on a small clinical trial that successfully tested
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Framework helps clinicians identify serious spinal pathology
Rehabilitation clinicians and other health care professionals now have a framework for assessing and managing people who may have serious spinal pathologies. Detailed in a position statement about red flags for serious spinal injuries and disease, this new guidance for clinical practice was developed for the International Federation of Orthopaedic Manipulative Physical Therapists (IFOMPT) and publ
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People who compare themselves with others spend longer on Facebook
People who are prone to comparing themselves with others spend more time on Facebook, and the social network is considering changes that might remind people to avoid such comparisons
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Fifteen survival shelters that can save your life
Protecting yourself from the elements should be a priority when you're trapped in the wilderness. (Tim MacWelch/) This story was originally featured on Outdoor Life . Shelter is your top priority in most survival emergencies. Severe weather conditions can kill within a few hours if you don't have some type of shelter to defend you from the elements. Luckily, there are a wide array of techniques a
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Biodegradable glitter and pollution-eating microalgae: the new materials inspired by nature
The iridescence of marble berries and the clever, light-bending perforations of microalgae are inspiring scientists to create biodegradable glitter and makeup pigments, and bionic algae to use in lasers or to clean pollutants.
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NHS to increase number of Covid-19 patients receiving antibody therapy
All hospital patients with coronavirus in England to be eligible for convalescent plasma Coronavirus – latest updates See all our coronavirus coverage Hospitals in England will increase the number of people getting blood plasma transfusions from recovered Covid-19 patients this week, to learn whether the antibody-rich serum can help combat the disease. So far few severely ill patients in UK inten
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The best affordable headphones for working out
Turn up when you pull-up. ( Danielle Cerullo via Unsplash/) If you've ever gotten to the gym only to discover to your horror that you've forgotten your headphones, you understand how ready access to music or podcasts is as vital to your exercise routine as water and sneakers. You need your hype music or soothing true crime narrative to get you through, and your headphones better be there for the
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A better way to split water molecules to produce hydrogen using sunlight
A team of researchers affiliated with several institutions in Japan has developed a better way to split water molecules to produce hydrogen using sunlight. In their paper published in the journal Nature, the group describes their technique and how well it worked. Simone Pokrant with Inscripta, Inc. has published a News and Views piece outlining the problems that scientists have faced in trying to
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Ingeniører kårer for 20. gang i træk Novo Nordisk som landets mest attraktive arbejdsplads
I medgang og modgang har de danske ingeniører elsket Novo Nordisk gennem alle de 20 år, Ingeniøren har udgivet sin årlige Profilanalyse. Læs vinderinterviewet med medicinalkoncernens CEO, Lars Fruergaard Jørgensen.
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Ni nye læger optaget i Kraks Blå Bog
Kraks Blå Bog over prominente danskere har fået tilføjet ni nye læger til listen. Du kan se hele listen her med bl.a. Imran Rashid og læge og chefredaktør på Dagens Medicin, Rikke Esbjerg.
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Extremely intense radio burst detected from magnetar SGR 1935+2154
Using the Canadian Hydrogen Intensity Mapping Experiment (CHIME) radio telescope, astronomers have detected a bright, millisecond-duration radio burst from a galactic magnetar known as SGR 1935+2154. The discovery of such an extremely intense event, reported in a paper published May 20, could be important for improving the understanding of the origin of fast radio bursts (FRBs).
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Tom Cruise Is Making a Movie in Space With SpaceX and NASA
The actor is reportedly working with director Doug Liman on the film.
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Graduation Gift Ideas (2020): The 15 Best Gifts For Your College Grad
This year's students have been through a lot. Here are 15 graduation gift ideas, from coffee makers and tablets to an Amazon Prime subscription.
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What Is a Clinical Trial?
The only way to know if a medical treatment actually works is with a randomized-controlled trial.
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Nyt dansk parkeringsur vil rejse penge på Kickstarter
PLUS. Parkeringsur med forbindelse til din telefon holder styr på parkeringszone og husker at stoppe betalingen. Men der skulle et specielt trick til for at den fungerede. De danske iværksættere lancerer nu kampagne på Kickstarter.
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AI reveals mechanism for kin selection in a wild primate
More like mom or dad? Human babies always get this curious look in their faces combined with the question of whom the child resembles most. The answers vary depending on the degree of kinship, gender and the time of assessment. Mandrills, monkeys living in Equatorial Africa, may recognize facial features coding relatedness better than humans. Scientists showed by using up-to-date artificial intell
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Initial Upper Paleolithic technology reached North China by ~41,000 years ago
A wave of new technology in the Late Paleolithic had reached North China by around 41,000 years ago.
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Ny ledtråd i den genetiska jakten på karies
Enligt regeringsformen är alla Sveriges invånare lika inför lagen. Något vi däremot inte tycks vara lika inför är benägenheten att få hål i tänderna. – De flesta i Sverige är kariesfria eller bara måttligt drabbade, men sen har vi en grupp på ungefär 20 procent som får väldigt mycket karies och som vi inte förstår oss på, säger Linda Eriksson, tandläkare och nydisputerad doktor i odontologi som ta
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Women with caring responsibilities at greater risk of poverty
A new report by UNSW Social Policy Research Centre (SPRC) and Australian Council of Social Services (ACOSS) highlights the relationship between caring roles and poverty in Australia. Before the COVID-19 pandemic, households with a female main income earner and children were more than twice as likely to live in poverty as those with a male main income earner.
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Minimum wage increases a mixed bag, but 'not a good idea' amid crisis
If the post-pandemic economic return includes minimum-wage increases across a few or many states, research led by Washington University in St. Louis scientists in the Olin Business School suggests that some positive and negative effects for U.S. workers follow in the two years after implementation.
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In stressed ecosystems Jurassic dinosaurs turned to scavenging, maybe even cannibalism
Among dinosaurs of ancient Colorado, scavenging and possibly cannibalism were responses to a resource-scarce environment, according to a new study.
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Study investigates Atlantic Rainforest regeneration in the state of São Paulo
The Atlantic Rainforest has been so savagely clearcut and burned over several centuries that only approximately 12% now remains. Nevertheless, it is still one of the planet's largest repositories of biodiversity, and counter to a process that appeared irreversible, forest cover in the biome has begun to recover in recent decades.
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Fighting parasites with poo
Sheep poo could hold the key to developing the next generatation of antiparasitic treatments that could protect Australian livestock and save the industry millions of dollars a year.
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Neutrophil Extracellular Traps May Augur Severe COVID-19
These webs of chromatin and proteins, released by immune cells to control microbial infections, could serve as a therapeutic target in coronavirus infections.
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Study investigates Atlantic Rainforest regeneration in the state of São Paulo
The Atlantic Rainforest has been so savagely clearcut and burned over several centuries that only approximately 12% now remains. Nevertheless, it is still one of the planet's largest repositories of biodiversity, and counter to a process that appeared irreversible, forest cover in the biome has begun to recover in recent decades.
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Fighting parasites with poo
Sheep poo could hold the key to developing the next generatation of antiparasitic treatments that could protect Australian livestock and save the industry millions of dollars a year.
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How China Is Planning to Win Back the World
It was posed as an innocent question, not an accusation. If the U.S. was so concerned about transparency, China's Foreign Ministry spokesperson Hua Chunying wondered aloud to nearly half a million followers on Twitter earlier this month, why not open its own biodefense lab in Maryland's Fort Detrick to international inspectors? Hua's tweet was also an invitation to a conspiracy theory, and a mess
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Asteroid Impact That Killed Dinosaurs 'Worst-Case' Scenario: Scientists
Credit: NASA We've known for several decades that the dinosaurs were most likely wiped out by a meteor impact, but ongoing research continues to discover new nuances to the overall situation. New data published in Nature Communications suggests that the dinosaur-killer hit at a steep and somewhat uncommon angle — and that the consequences for life on Earth were significant. Most reports and discu
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AMP releases preliminary results to nationwide SARS-CoV-2 molecular testing survey
The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, today released the preliminary results of its April 2020 SARS-CoV-2 Testing Survey for clinical laboratories. The anonymous survey was created and administered to document clinical laboratory efforts and experiences. The results will be used to help inform future advocacy and clinical prac
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Asteroids Ryugu and Bennu were formed by the destruction of a large asteroid
What is the origin of the asteroids Bennu and Ryugu, and of their spinning-top shape? An international research team led by Patrick Michel, a CNRS researcher at the Laboratoire Lagrange (CNRS/Observatoire de la Côte d'Azur/Université Côte d'Azur) and Ronald-Louis Ballouz from the University of Arizona, proposes an answer to this question in an article published in Nature Communications on May 27,
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Will movie theaters survive COVID-19?
The season of blockbusters is upon us, but theaters have been empty for months—and it's unclear what they'll show, or who will come, when they reopen. Derek Long focuses on the history of the film industry, in particular film distribution, as a professor of media and cinema studies at Illinois. He spoke with News Bureau social sciences editor Craig Chamberlain about the state of movies, current an
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Study of Cantonese lexical tone shows language evolution possibly linked to genes
A research group led by Professor Patrick Chun Man Wong, Stanley Ho Professor of Cognitive Neuroscience of the Department of Linguistics and Modern Languages, recruited more than 400 native speakers of Cantonese for a study. The results show that participants with a specific genotype of the ASPM gene are better at perceiving lexical tone in Cantonese, and those without it may improve their abiliti
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US government is funding website spreading Covid-19 disinformation
State Department-backed Armenian project to promote democracy instead features false information Coronavirus – latest updates See all our coronavirus coverage The US government is funding a website in Armenia which is spreading disinformation about the coronavirus pandemic, including warnings that Armenians ought to "refuse" future vaccine programmes. The website, Medmedia.am, was launched with t
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Technology uses plant biomass waste for self-powered biomedical devices
An innovation turning waste material into stretchable devices may soon provide a new option for creating self-powered biomedical inventions.
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Video: The long arm and short legs wars in palaeoanthropology
For decades a war raged within the field of palaeoanthropology. At the center of the battle were some of the most important fossils hominids ever discovered, the fossils from Hadar in Ethiopia, and included the famous Lucy fossil. The question was, did hominids climb, or was their adaptation to bipedalism so complete as to preclude arboreal behaviours?
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New Zealand sits on top of the remains of a giant ancient volcanic plume
Back in the 1970s, scientists came up with a revolutionary idea about how Earth's deep interior works. They proposed it is slowly churning like a lava lamp, with buoyant blobs rising as plumes of hot mantle rock from near Earth's core, where rocks are so hot they move like a fluid.
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En spraydusch i näsan kan bli framtidens coronavaccin
Ett coronavaccin i form av en nässpray som triggar igång exakt rätt immunceller. Genom ett brett samarbete mellan flera lärosäten och externa aktörer försöker ett pilotprojektpå Chalmers hitta ett nytt sätt att tackla såväl covid-19 som andra virus som angriper våra celler. Ett coronavaccin i form av en nässpray som triggar igång exakt rätt immunceller. Det hoppas forskarna i ett nytt Chalmerslet
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New research on 'endowment effect' points to evolutionary roots of cognitive biases
New research may explain why we sometimes overvalue items we've acquired—to an irrational degree—irrespective of their market or sentimental value. This phenomenon is called the endowment effect, and researchers have long puzzled over why it occurs, and why the size of the effect can vary so much across items when it does. It's important to understand, however, because the endowment effect can lea
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5 Mobile Keyboards Reviewed: Arteck, Plugable, Sounwill, Moko, Jelly Comb
We review five foldable, phone-friendly keyboards you can toss in your pocket.
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Covid-19 Creates Long, Anxious Waits for Fertility Treatments
As fertility clinics gradually reopen, patients and doctors must weigh the risks of seeking pregnancy during a pandemic—or waiting too long to try.
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Coronavirus: a growing number of people are avoiding news
When the coronavirus pandemic really started to take hold in the UK in March, news consumption increased, as in many other countries. But, since then, our research shows that an increasing share of the UK population is switching off from the news.
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Study investigates New Zealanders' attitudes toward working from home
A University of Otago study of 2,595 New Zealanders working from home during lockdown suggests that most people were equally or more productive (73 per cent), and that many want to continue to work from home at least part of the time post lockdown (89 per cent).
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New research on 'endowment effect' points to evolutionary roots of cognitive biases
New research may explain why we sometimes overvalue items we've acquired—to an irrational degree—irrespective of their market or sentimental value. This phenomenon is called the endowment effect, and researchers have long puzzled over why it occurs, and why the size of the effect can vary so much across items when it does. It's important to understand, however, because the endowment effect can lea
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Europe's battle lines are drawn at a perilous time
There is only one way forward — for leaders to work with, not against each other
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Managing the coronavirus challenge
A look inside companies grappling with the consequences of the pandemic
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New Zealand government ignores expert advice in its plan to improve water quality in rivers and lakes
New Zealand's government has been praised for listening to health experts in its pandemic response, but when it comes to dealing with pollution of the country's waterways, scientific advice seems less important.
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Confidence Drives Confirmation Bias
Human thought processes are powerful but flawed, like a GPS system that uses broken algorithms to lead you to the wrong destination. Psychologists study these cognitive biases and heuristic patterns of thought to better understand these flaws and propose possible fixes to mitigate them. To a large degree, scientific skepticism is about exactly that – identifying and compensating for the flaws in
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Europe's virus-stricken economy shows tentative signs of recovery
Business and consumer confidence starts to rebound from record lows
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What COVID-19 means for the people making your clothes
Workers everywhere are feeling the impact of COVID-19 and the restrictions necessitated by COVID-19.
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Quality of life in high-density apartments varies—here are 6 ways to improve it
We're building a lot of apartments in Australia. High-density precincts are being developed across our major cities. But these buildings and neighbourhoods are often not designed and managed in ways that meet the needs of lower-income residents.
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New iguana species found hiding in plain sight
This is the tale of two iguanas. Or five iguanas and counting, if you prefer. Bear with us, because this isn't straightforward.
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World's oldest bug is fossil millipede from Scotland
A 425-million-year-old millipede fossil from the Scottish island of Kerrera is the world's oldest "bug"—older than any known fossil of an insect, arachnid or other related creepy-crawly, according to researchers at The University of Texas at Austin.
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Ethical guidelines for COVID-19 tracing apps
Nature, Published online: 28 May 2020; doi:10.1038/d41586-020-01578-0 Protect privacy, equality and fairness in digital contact tracing with these key questions.
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New iguana species found hiding in plain sight
This is the tale of two iguanas. Or five iguanas and counting, if you prefer. Bear with us, because this isn't straightforward.
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Australia, you have unfinished business. It's time to let our 'fire people' care for this land
Since last summer's bushfire crisis, there's been a quantum shift in public awareness of Aboriginal fire management. It's now more widely understood that Aboriginal people used landscape burning to sustain biodiversity and suppress large bushfires.
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Businesses can build trust with consumers by unlocking data about their practices
Recent public demonstrations against climate change, human rights violations and industry practices that harm the environment reveal a growing public desire to participate in discussions about sustainability, safety and citizen's rights.
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ESPRESSO confirms the presence of an Earth around the nearest star
The existence of a planet the size of Earth around the closest star in the solar system, Proxima Centauri, has been confirmed by an international team of scientists including researchers from the University of Geneva (UNIGE). The results, published in Astronomy & Astrophysics, reveal that the planet in question, Proxima b, has a mass of 1.17 Earth masses and is located in the habitable zone of its
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Have resistance, will travel
Around the world, pest insects like mosquitoes often become resistant to the insecticides meant to control them, causing problems for agriculture and public health.
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Have resistance, will travel
Around the world, pest insects like mosquitoes often become resistant to the insecticides meant to control them, causing problems for agriculture and public health.
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Collecting race-based data during coronavirus pandemic may fuel dangerous prejudices
Brian Sinclair wheeled himself into a Winnipeg emergency room in September 2008 seeking assistance with his catheter bag. He had a bladder infection, but instead of receiving treatment, remained in the waiting room for 34 hours until his body—now lifeless—finally received medical attention.
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Teaching experimental science in a time of social distancing
When lockdown measures were announced in France and other countries, secondary-school teachers and university professors had to quickly make the transition from classroom teaching to remote education. As a result, practical work was often abandoned—experiments were no longer possible without a lab, test tubes, oscilloscopes and other equipment.
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Avfallsätande svamp till efterrätt
Svampar har varit i människans tjänst länge, inte bara som matsvamp, utan även som till exempel penicillin. Mer sentida svampuppfinningar är köttsubstitutet Quorn, som görs av en mögelsvamp, och bioetanol, som görs på avfall med hjälp av en sporsäckssvamp. Vid ett seminarium på högskolan i Borås i höstas bjöds på en hel meny av mat gjord på restätande svampar, från svampburgare med svampmajonnäs t
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How Europe's CHEOPS satellite will improve the hunt for exoplanets
While the planet has been on lockdown the last two months, a new space telescope called CHEOPS opened its eyes, took its first pictures of the heavens and is now open for business.
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People who compare themselves to others spend longer on Facebook
People who are prone to comparing themselves to others spend more time on Facebook, and the social network is considering changes that might remind people to avoid such comparisons
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A Day in the Life of a COVID-19 Physician
The pandemic challenges a young critical care doctor in ways he could never have imagined — Read more on ScientificAmerican.com
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Boring but Very Nasty
On Tuesday evening, President Trump tweeted this: Great News: The boring but very nasty magazine, The Atlantic, is rapidly failing, going down the tubes, and has just been forced to announce it is laying off at least 20% of its staff in order to limp into the future. This is a tough time to be in the Fake News Business! — Donald J. Trump (@realDonaldTrump) May 27, 2020 Writing a column to prove t
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This Summer Will Scar Young Americans for Life
T he summer after her freshman year in a New York City high school, Carmen Lopez Villamil made $2,000 working in a molecular-biology laboratory. "Turns out I don't like biology," she said, laughing. "But it was incredible." She got to design her own research project, worked alongside scientists, and developed a relationship with a mentor. This year, with her junior-year coursework nearly complete
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Huden – kroppens største organ og forsvarsværk
Vitaminer, pigment og berøring. Vores hud har mange funktioner og er et vitalt organ, der måske…
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Kvinnor med anlag från neandertalare föder fler barn
Redan 2010 rapporterade den svenske genetikern Svante Pääbo att moderna människor måste ha fått barn tillsammans med neandertalare för mer än 50 000 år sedan, och att många av oss moderna människor fortfarande bär på genetiska arv från dem. Mellan 1,5 och 4 procent av arvsmassan hos folk med europeisk eller asiatisk härkomst kommer från våra sedan länge utdöda släktingar.
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Snarrådige læger sikrer Remdesivir til Danmark – men kun til to hospitaler
PLUS. Kun to københavnske hospitaler har adgang til lægemidlet Remdesivir, der viser gode resultater i behandling af covid-19. Men dansk lovgivning forhindrer, at de deler midlet med andre sygehuse.
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'If Found' Is an Essential Game About Letting Go of the Past
Dreamfeel's visual novel tells a compelling queer coming-of-age story, with a surreal sci-fi twist.
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To Beat Covid-19, You Have to Know How A Virus Moves
As public spaces reopen, scientists are racing to understand the mysterious and turbulent way the disease spreads through air—from person to person, and place to place.
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Remote Work Has Its Perks, Until You Want a Promotion
Companies like Facebook and Twitter expect many employees to work far from headquarters after the pandemic. That calls for a change in corporate cultures.
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Apple MacBook Pro (13-Inch, 2020) Review: Portable, Powerful, Pedestrian
The middle child in Apple's Mac line marries power and portability—and offers it at a steep price.
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A Day in the Life of a COVID-19 Physician
The pandemic challenges a young critical care doctor in ways he could never have imagined — Read more on ScientificAmerican.com
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Americans Aren't Getting the Advice They Need
In the midst of the coronavirus pandemic, the government of the Netherlands made an unusual suggestion to single people: Get a quarantine seksbuddy . Many individuals who aren't in a relationship still need physical intimacy, and having one consistent sex partner is much less likely to promote the spread of the coronavirus than having multiple partners is. Dutch public-health officials were simpl
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COVID-19 Vaccine Developers Search for Antibodies That 'First Do No Harm'
Biotechs and pharma want to protect patients without triggering immune system havoc — Read more on ScientificAmerican.com
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Easing the lockdown: how will we know if infections bounce back?
Analysis of rate of transmission, NHS 111 calls and Google location data will inform next steps Coronavirus – latest updates See all our coronavirus coverage The government's plan to ease the lockdown will be confirmed in an official review that Downing Street expects will give the all clear for schools to begin reopening next week. No 10 said the proposed steps for England should be outlined at
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COVID-19 Vaccine Developers Search for Antibodies That 'First Do No Harm'
Biotechs and pharma want to protect patients without triggering immune system havoc — Read more on ScientificAmerican.com
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Microsoft undersøger 10 fejl i nyeste Windows 10-opdatering
Den seneste opdatering af Windows 10 udkom i går, den 27. maj. I dag fremgår det på virksomhedens hjemmeside, at man er i gang med at undersøge 10 fejl.
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I Miss My Grandchildren
One of the (very few) benefits of being in my 60s is that I can finally own up to a trait that's pretty retro: that what I cherish most in life is my family. I might endanger my credentials as a second-wave feminist with this admission, but I've come to realize that the pleasure I get from being with my daughters, their husbands, and my granddaughters outshines whatever pride I take in my writing
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Sådan renses sandet fra Høfte 42
90 ton sand fra den forurenede høfde 42 er blevet renset for kviksølv og pesticider. Sandet er nu rent nok til at kunne bruges igen, men miljøministeren har igen udskudt finansieringen af oprydningen.
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The death marker protein cleans up your muscles after exercise
Researchers at the University of Copenhagen's Department of Nutrition, Exercise and Sports have demonstrated that physical activity prompts a clean-up of muscles as the protein Ubiquitin tags onto worn-out proteins, causing them to be degraded. This prevents the accumulation of damaged proteins and helps keep muscles healthy.
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Why Are So Many Republicans Remaining Silent?
Earlier this month, Representative Adam Kinzinger told his constituents that he is worried by the excessive number of conspiracy theories he has seen circulating lately on social-media sites. "As leaders, we have a choice," he told his constituents in a video message posted to Facebook. "There's far too many who will simply reflect back that paranoia, to feed fuel to that fire, if it'll help thei
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The Coming Setback for Women in the Workplace
An executive at a major French cosmetics company told me she's been running a team of 70 and overseeing her kids' schooling while her husband, a nurse, works long hours treating coronavirus patients in a Paris hospital. Another executive, at an energy company, has been working full-time—as well as doing all the cooking and cleaning, and making sure her kids take their online classes—because her h
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Coronavirus Global News Tracker: Live Updates
The program is aimed at replacing a nationwide lockdown in Britain with individual isolation or localized restrictions. And in Mexico, the pandemic is straining a hobbled health care system.
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STARTS 11 AM ET | The 'Great Midlife Edit': How to master your middle years
Add event to calendar Aging is inevitable, but it doesn't have to be so taboo. After helping turn AirBnB into a multi-billion-dollar business, rebel hotelier Chip Conley founded the Modern Elder Academy , the world's first midlife wisdom school to help people navigate their midlives and tune into the advantages of their life experiences. In conversation with executive recruiter James Citrin, Conl
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An attempt at a triple play seems likely to result in a retraction
A group of researchers in China is teetering on the edge of losing a paper because they have apparently tried to publish it three times. Our story starts in Turkey, home to Taner Kemal Erdag, the editor in chief of Turkish Archives of Otorhinolaryngology. In August 2018, Erdag received a submission titled "Increased maternal serum … Continue reading
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US relaxes rules for opioid substitutes during lockdowns
Trump administration makes it easier for addicts to obtain methadone and other treatment drugs
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Lockdown countdown: a farmer and a fruit-picker face the future with hope — and trepidation
In this FT series, people share their stories of this extraordinary time
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Coronavirus Live Updates: Testing in the U.S. Becomes Major Campaign Issue
Testing becomes a campaign issue: President Trump would leave it to the states, while Joseph R. Biden Jr. said he would create a national program. Even the hardest-hit cities are far from herd immunity.
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It's game on for an EU of common purpose
What the new coronavirus recovery plan does and does not do
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Ingeniørernes ledighedskurve knækker den gale vej
PLUS. Traditionen tro falder ingeniørarbejdsløsheden fra marts til april, men i år stiger den. Situationen giver anledning til bekymring, men IDA trykker ikke på alarmknappen endnu.
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The CEO's guide to safely reopening the workplace
Perhaps the single biggest implication of reopening national economies is that responsibility and thus liability for dealing with the covid-19 pandemic will shift from the public to the private sector. Fortune 500 CEOs and small business owners alike will soon be making decisions that affect the health not only of their business but also their people (employees, contractors, customers, suppliers)
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These countries are leading the transition to sustainable energy
What does COVID-19 mean for the energy transition? While lockdowns have caused a temporary fall in CO2 emissions, the pandemic risks derailing recent progress in addressing the world's energy challenges. The current state of the sector is described in the World Economic Forum's Energy Transition Index 2020 . It benchmarks the energy systems of 115 economies, highlighting the leading players in th
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American Indians and Alaska Natives have disproportionately higher rates of CVD
Type 2 diabetes, a major risk factor for cardiovascular disease, affects American Indians and Alaska Natives at three times the rate of white Americans.American Indians and Alaska Natives face additional environmental and socio-economic challenges, including historical marginalization, less access to health care and exposure to toxic metals in the water.
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Why Americans Might Not Trust the Election Results
Nearly three in five Americans don't have confidence in the honesty of our elections, a February Gallup poll found. Republicans, Democrats, state officials, grandmothers, first-time voters, the politically engaged, the anti-institutionalists—pretty much the only thing they could agree on was their doubts about the integrity of our democracy. And that was before the pandemic made everything worse.
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GSK to produce 1bn doses of coronavirus vaccine booster in 2021
World's largest vaccine maker in talks with governments over manufacturing expansion Coronavirus – latest updates See all our coronavirus coverage GlaxoSmithKline plans to produce 1bn doses of vaccine efficacy boosters, or adjuvants, next year for use in Covid-19 treatment. The world's largest vaccine maker said it was in talks with governments to back a manufacturing expansion that would help to
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Society Is Becoming Germaphobic. Let's Not Stay That Way.
In the midst of the Covid-19 pandemic, society's heightened anxiety about contamination is probably helping to save lives. But if that anxiety crystallizes into a long-term, habitual fear of microbes, it could potentially become a danger to public health — and to the broader social sphere.
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Dräneringsystem i kroppens hårdaste ben kan förklara yrselsjukdoms uppkomst
Balansorganet i innerörat är omgivet av kroppens hårdaste ben. Med hjälp av så kallad synkrotronröntgen har forskare vid Uppsala universitet upptäckt ett dränagesystem som förmodligen spelar en stor roll för uppkomsten av den vanliga och besvärliga sjukdomen Meniere. Sjukdomen Meniere yttrar sig i plötsligt påkomna yrselattacker, hörselnedsättning och tinnitus. Sjukdomen anses bero på att för myc
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Is the "science" behind the lockdown any good?
(Spoiler: it's a lot better than nothing. But it should not be followed at the expense of all else.)
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Pandemic crisis prompts revival in trade union membership
Fears of redundancy and increased anxiety drive surge in numbers
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Rekordmånga träd dör av annat än avverkning
Virkesförrådet i den svenska skogen fortsätter att öka, men nu i långsammare takt. Sveriges totala virkesförråd uppgår nu till 3,6 miljarder skogskubikmeter, visar SLU:s statistik från Riksskogstaxeringen 2020. Enligt officiell statistik är den totala årliga tillväxten i Sverige 123 miljoner m3sk (miljarder skogskubikmeter) per år jämfört med nästan 130 miljoner m3sk, för fem år sedan. – Orsakern
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The pandemic made life harder for deaf people. The solutions could benefit everyone.
About a month after shelter-in-place orders began in her area, Shaylee Mansfield—an 11-year-old deaf actress in Austin, Texas—posted a video on Twitter. For over 30 years, DHH people fought for captioning. More people r now relying on technology during coronavirus. Shaylee Mansfield, Deaf girl, had enough! She sends a loud message to @instagram to add #instacaptioning on their platform for over 4
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GSK targets production of 1bn doses of coronavirus vaccine booster
Drugmaker says adjuvant would allow for more doses and offer longer-lasting immunity
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SSI om dansk maske-enegang: Lande har også forskellige hastighedsbegrænsninger
PLUS. Danmark er sammen med Sverige de eneste EU-lande, som ikke anbefaler eller kræver, at borgerne bruger ansigtsmasker.
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EasyJet to cut 4,500 jobs and reduce capacity
Budget airline warns recovery will take until 2023 and lays out plans to run about 30 per cent of flights during summer period
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States, cities challenge Trump mileage standards rollback
Nearly two dozen states and several cities on Wednesday filed a legal challenge to the Trump administration's rollback of Obama-era mileage standards, saying science backed up the old regulations developed with the help of the nation's car makers.
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Questions raised over hydroxychloroquine study which caused WHO to halt trials for Covid-19
Exclusive: Australian researchers query origin of data used for Lancet study, but stress there is no evidence drug is a safe or effective treatment • Sign up for Guardian Australia's daily coronavirus email • Download the free Guardian app to get the most important news notifications Questions have been raised by Australian infectious disease researchers about a study published in the Lancet whic
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Tre ud af fire internationale studerende har været ængstelige under coronakrisen
Mange internationale studerende ved Københavns Universitet har kæmpet med isolation, ensomhed…
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Summer forage capabilities of tepary bean and guar in the southern great plains
Perennial warm-season grasses do not provide high-quality forage during mid to late-summer, which limits yearling stocker cattle from maintaining high rates of growth in the Southern Great Plains. This shortage has resulted in a continual search by researchers for annual legumes that can provide sufficient amounts of nutritious forage during August through September.
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Summer forage capabilities of tepary bean and guar in the southern great plains
Perennial warm-season grasses do not provide high-quality forage during mid to late-summer, which limits yearling stocker cattle from maintaining high rates of growth in the Southern Great Plains. This shortage has resulted in a continual search by researchers for annual legumes that can provide sufficient amounts of nutritious forage during August through September.
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Inte bara hamburgaren – många olika faktorer ökar risken för fetma
En ny studie visar att mångfacetterade faktorer i bostadsområdena och individuella faktorer bidrar till att öka risken för att utveckla fetma, snarare än enstaka faktorer i omgivningarna, som tidigare antagits ligga bakom de höga nivåerna av fetma i vissa bostadsområden.
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UK coronavirus live: test and trace gets under way in England and Scotland
Council leaders warn they lack powers to make local lockdowns work, as Tory MPs resist PM's call to move on from the Dominic Cummings furore Tory anger at Cummings grows as dozens of MPs defy Boris Johnson Hancock: it is public's 'civic duty' to follow test-and-trace instructions Government target of 200,000 Covid-19 tests 'meaningless' – experts Global coronavirus updates – live See all our coro
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Out of My Skull by James Danckert and John D Eastwood – the psychology of boredom
From social media addiction to the discovery of musical genius – is the alleviation of boredom what really drives the world? According to the great proto-existentialist philosopher Arthur Schopenhauer, the life of a human or other beast "swings like a pendulum back and forth between pain and boredom". Indeed, pain (or want) and boredom are the two main constituents of existence, and not only duri
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Dødsmærkeproteinet rydder op i dine muskler efter fysisk aktivitet
Forskere fra Institut for Idræt og Ernæring ved Københavns Universitet har vist, at fysisk…
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Coronavirus latest: at a glance
A summary of the biggest developments in the global coronavirus outbreak Follow our latest coronavirus blog for live news and updates Key developments in the global coronavirus outbreak today include: Continue reading…
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Live Coronavirus News: World Updates
A fire tore through a Covid-19 ward in Bangladesh, killing five. And scientists are revising the timeline of when the virus reached Europe and the United States.
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Government target of 200,000 Covid-19 tests 'meaningless'
Senior scientists say published data on testing doesn't adhere to basic rules of statistics Coronavirus – latest updates See all our coronavirus coverage The government's target of hitting 200,000 Covid-19 daily tests by Monday has been described as "meaningless" by senior scientists, who say that the published data on testing does not adhere to the basic rules of statistics. Experts told the Gua
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The coronavirus infection rate is still too high. There will probably be a second wave | David Hunter
Test and tracing is launching today but, as the lockdown eases, it will need to be massively stepped up to have a significant impact David Hunter is professor of epidemiology at the University of Oxford Coronavirus – latest updates See all our coronavirus coverage We all now know the basics – the R is the average number of people someone infected with Covid-19 passes the virus on to. If it is gre
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Exposure to 'good bacteria' during pregnancy buffers risk of autism-like syndrome
Giving beneficial bacteria to stressed mothers during the equivalent of the third trimester of pregnancy prevents an autism-like disorder in their offspring, according to a new animal study.
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Hård motion smadrer proteinerne i dine muskler: Derfor er det en god ting
Bare ti minutter på cyklen forbedrer dine muskler.
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Adolescent exposure to anesthetics may cause alcohol use disorder, new research shows
Early exposure to anesthetics may make adolescents more susceptible to developing alcohol use disorder (AUD), according to new research from Binghamton University, State University of New York.
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Summer forage capabilities of tepary bean and guar in the southern great plains
Research identifies tepary bean and guar as potential summer forages.
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Unique 'home built' device provides fast disease analysis in kidneys affected by diabetes
The amount of scarring in damaged kidneys as a result of diabetes or acute injury, is a key factor in determining treatment. But it has not been possible, using traditional techniques, to quickly and accurately assess how widespread this kind of wounding extends within the organ. Now, however, a physicist and chemist at Georgetown University Medical Center has shown that a microscope he began deve
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Public option would lower health premiums, but not greatly expand coverage
State and federal lawmakers have expressed interest in creating a public health insurance option, with four different bills that would create a federal public option being introduced in the Congress in 2019.A new study that modeled four scenarios for offering a government-sponsored health plan finds that a public option could lower the cost of premiums, but on its own it is unlikely to substantial
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Altered sense of taste present in half of COVID-19 cases
A systematic review of COVID-19 cases finds nearly half of patients reported changes to or complete loss of their sense of taste. The finding furthers the evidence that changes in taste are a valid screening tool for COVID-19.
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Pressure on HK, Boeing's Max assembly, EU fund
How the US move could affect Hong Kong's standing as a global financial centre
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When did modern humans first arrive in Europe? – podcast
New archaeological discoveries in the Bacho Kiro cave in Bulgaria have revealed that modern humans co-existed with Neanderthals for several thousand years. Nicola Davis speaks to Prof Jean-Jacques Hublin about the excavations, and what their findings tell us about when modern humans first arrived in Europe Continue reading…
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When did modern humans first arrive in Europe?
New archaeological discoveries in the Bacho Kiro cave in Bulgaria have revealed that modern humans co-existed with Neanderthals for several thousand years. Nicola Davis speaks to Prof Jean-Jacques Hublin about the excavations, and what their findings tell us about when modern humans first arrived in Europe. Help support our independent journalism at theguardian.com/sciencepod
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Covid-19 crisis reveals supply chain vulnerability
Although flexible networks have held up well, parts of the food chain are struggling
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Restaurants and hotels clean up with toilet paper sales
As panic-buying empties supermarket shelves, cafés and offices remain flush with toilet roll
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Will coronavirus finally kill off global supply chains?
With worldwide goods trade in freefall, companies and governments have many lessons to learn
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Designing insurance for the next pandemic
The industry is already planning for the next crisis — and the threat of a second wave means it might be only months away
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Spain to push through minimum income guarantee to fight poverty
Measure is part of leftwing government's legislation as economic crisis deepens
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EU recovery fund faces prodigious hurdles to reach consensus
Member states pore over €750bn borrowing plan as they seek route out of budget impasse
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What's next for US coronavirus response? Ask FT journalists
Demetri Sevastopulo, Andrew Edgecliffe-Johnson and Laura Noonan share insights from managers and officials
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Successful investors learn from history
The current crisis has accelerated existing investment trends
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Jared Diamond: lessons from a pandemic
The coronavirus crisis should usher in an age of global co-operation, argues the Pulitzer Prize-winning geographer
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Be wary of scapegoating 'just-in-time' supply chains
Argument that diversifying or reshoring is necessary is easy to make but oversimplified
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Banks determined to lock in Covid-19 tech changes
Pandemic is forcing progress in a security-conscious field — but can it be maintained?
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Lessons of lockdown help disabled people at work
Remote working shows how businesses can become more inclusive
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Vast majority of New Zealanders don't want to return to office after Covid-19
Study finds 89% of people working from home want to stay there, at least part time, when workplaces reopen Coronavirus – latest updates See all our coronavirus coverage A study of New Zealanders working from home during coronavirus lockdown has found many were just as productive as when they were in the office, and a majority were reluctant to return to traditional workplaces. New Zealand went in
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Det pønser C#'s danske chef på i version ni: Ind med records og ud med static void Main()
Ligesom i Java er poster på vej til C#, sammen med mange andre nyheder.
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Opråb fra forskere: Mademballage bugner af sundhedsskadelige kemikalier
PLUS. Det videnskabelige samfund og mere end 170 organisationer rejser alvorlige bekymringer om anvendelsen af kemikalier i emballage, der udgør en trussel mod menneskers helbred.
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UK suffers second-highest death rate from coronavirus
FT analysis of data from 19 countries finds Britain suffering heavy toll from pandemic
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UK had no stocks of protective gowns when coronavirus struck
Government failed to take swift action after warning from top scientific advisers last June
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'We Loved Each Other': Fauci Recalls Larry Kramer, Friend and Nemesis
In public, the activist berated the infectious disease expert for federal inaction on AIDS. But their affection lasted decades and changed the course of the epidemic.
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Calculating Your Way to Antivirals
My intent is to start mixing in some non-coronavirus posts along with my pandemic science coverage – you know, like the blog used to be way back earlier in the year (!) Today's subject might be a good transitional one – it's an article in the New England Journal of Medicine on coronavirus drug discovery, but the points it raises are generally applicable. "How to Discover Antiviral Drugs Quickly"
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Colorful Corals Beat Bleaching
Exposed to mildly warmer waters, some corals turn neon instead of bleaching white. The dramatic colors may help coax symbiotic algae back. Christopher Intagliata reports.
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Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches [Biophysics and Computational Biology]
Networks of branched actin filaments formed by Arp2/3 complex generate and experience mechanical forces during essential cellular functions, including cell motility and endocytosis. External forces regulate the assembly and architecture of branched actin networks both in vitro and in cells. Considerably less is known about how mechanical forces influence the…
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Context-dependent and dynamic functional influence of corticothalamic pathways to first- and higher-order visual thalamus [Neuroscience]
Layer 6 (L6) is the sole purveyor of corticothalamic (CT) feedback to first-order thalamus and also sends projections to higher-order thalamus, yet how it engages the full corticothalamic circuit to contribute to sensory processing in an awake animal remains unknown. We sought to elucidate the functional impact of L6CT projections…
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Fire mosaics and habitat choice in nomadic foragers [Anthropology]
In the mid-1950s Western Desert of Australia, Aboriginal populations were in decline as families left for ration depots, cattle stations, and mission settlements. In the context of reduced population density, an ideal free-distribution model predicts landscape use should contract to the most productive habitats, and people should avoid areas that…
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Long-read bitter gourd (Momordica charantia) genome and the genomic architecture of nonclassic domestication [Plant Biology]
The genetic architecture of quantitative traits is determined by both Mendelian and polygenic factors, yet classic examples of plant domestication focused on selective sweep of newly mutated Mendelian genes. Here we report the chromosome-level genome assembly and the genomic investigation of a nonclassic domestication example, bitter gourd (Momordica charantia), an…
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Selective AhR knockout in langerin-expressing cells abates Langerhans cells and polarizes Th2/Tr1 in epicutaneous protein sensitization [Immunology and Inflammation]
The aryl hydrocarbon receptor (AhR) represents an environmental sensor regulating immune responses. In the skin, AhR is expressed in several cell types, including keratinocytes, epidermal Langerhans cells (LC), and dermal dendritic cells (DC). The mechanisms how AhR activates or inhibits cutaneous immune responses remain controversial, owing to differences in the…
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An aphid RNA transcript migrates systemically within plants and is a virulence factor [Agricultural Sciences]
Aphids are sap-feeding insects that colonize a broad range of plant species and often cause feeding damage and transmit plant pathogens, including bacteria, viruses, and viroids. These insects feed from the plant vascular tissue, predominantly the phloem. However, it remains largely unknown how aphids, and other sap-feeding insects, establish intimate…
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A parallelized, automated platform enabling individual or sequential ChIP of histone marks and transcription factors [Engineering]
Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq) remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. Here, we combine principles of microengineering, surface chemistry, and molecular biology to address the major limitations of standard ChIP-seq. The resulting technology, FloChIP, automates and miniaturizes ChIP in a bead
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High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D [Biophysics and Computational Biology]
Complete cancer regression occurs in a subset of patients following adoptive T cell therapy (ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs). However, the low success rate presents a great challenge to broader clinical application. To provide insight into TIL-based immunotherapy, we studied a successful case of ACT where regression…
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Photothermal modulation of human stem cells using light-responsive 2D nanomaterials [Engineering]
Two-dimensional (2D) molybdenum disulfide (MoS2) nanomaterials are an emerging class of biomaterials that are photoresponsive at near-infrared wavelengths (NIR). Here, we demonstrate the ability of 2D MoS2 to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS2 and NIR stimulation of MoS2 with human stem…
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Semisynthesis of an evasin from tick saliva reveals a critical role of tyrosine sulfation for chemokine binding and inhibition [Chemistry]
Blood-feeding arthropods produce antiinflammatory salivary proteins called evasins that function through inhibition of chemokine-receptor signaling in the host. Herein, we show that the evasin ACA-01 from the Amblyomma cajennense tick can be posttranslationally sulfated at two tyrosine residues, albeit as a mixture of sulfated variants. Homogenously sulfated variants of the…
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Loss of function of the Pad-1 aminotransferase gene, which is involved in auxin homeostasis, induces parthenocarpy in Solanaceae plants [Agricultural Sciences]
Fruit development normally occurs after pollination and fertilization; however, in parthenocarpic plants, the ovary grows into the fruit without pollination and/or fertilization. Parthenocarpy has been recognized as a highly attractive agronomic trait because it could stabilize fruit yield under unfavorable environmental conditions. Although natural parthenocarpic varieties are useful for breeding
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FcRn, but not Fc{gamma}Rs, drives maternal-fetal transplacental transport of human IgG antibodies [Immunology and Inflammation]
The IgG Fc domain has the capacity to interact with diverse types of receptors, including the neonatal Fc receptor (FcRn) and Fcγ receptors (FcγRs), which confer pleiotropic biological activities. Whereas FcRn regulates IgG epithelial transport and recycling, Fc effector activities, such as antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis, are mediated…
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Subpolar marginal seas fuel the North Pacific through the intermediate water at the termination of the global ocean circulation [Earth, Atmospheric, and Planetary Sciences]
The mechanism by which nutrients in the deep ocean are uplifted to maintain nutrient-rich surface waters in the subarctic Pacific has not been properly described. The iron (Fe) supply processes that control biological production in the nutrient-rich waters are also still under debate. Here, we report the processes that determine…
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Glycosaminoglycans accelerate biomimetic collagen mineralization in a tissue-based in vitro model [Biochemistry]
Mammalian teeth are attached to the jawbone through an exquisitely controlled mineralization process: unmineralized collagen fibers of the periodontal ligament anchor directly into the outer layer of adjoining mineralized tissues (cementum and bone). The sharp interface between mineralized and nonmineralized collagenous tissues makes this an excellent model to study the…
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Cultural evolution of conformity and anticonformity [Evolution]
Conformist bias occurs when the probability of adopting a more common cultural variant in a population exceeds its frequency, and anticonformist bias occurs when the reverse is true. Conformist and anticonformist bias have been widely documented in humans, and conformist bias has also been observed in many nonhuman animals. Boyd…
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USP37 promotes deubiquitination of HIF2{alpha} in kidney cancer [Medical Sciences]
Clear cell renal cell carcinoma (ccRCC) is characterized by loss of tumor suppressor Von Hippel Lindau (VHL) function, which leads to accumulation of hypoxia inducible factor α (including HIF1α and HIF2α). HIF2α was previously reported to be one of the major oncogenic drivers in ccRCC, however, its therapeutic targets remain…
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Adenine DNA methylation, 3D genome organization, and gene expression in the parasite Trichomonas vaginalis [Microbiology]
Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract causing infections that range from asymptomatic to highly inflammatory. Recent works have highlighted the importance of histone modifications in the regulation of transcription and parasite pathogenesis. However, the nature of DNA methylation in the parasite remains…
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A linear threshold model for optimal stopping behavior [Psychological and Cognitive Sciences]
In many real-life decisions, options are distributed in space and time, making it necessary to search sequentially through them, often without a chance to return to a rejected option. The optimal strategy in these tasks is to choose the first option that is above a threshold that depends on the…
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Science and Culture: "Design fiction" skirts reality to provoke discussion and debate [Social Sciences]
In October 2015, researchers presented an unusual paper at a computer science conference in London. The paper described the promising results of a pilot project in which a local community used surveillance drones to enforce car parking restrictions and to identify dog owners who failed to clean up after their…
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Core Concept: Managed retreat increasingly seen as necessary in response to climate change's fury [Economic Sciences]
As climate change causes seas to rise and fuels ever-stronger storms and droughts, humanity faces a stark choice. Communities can seek shelter from rising waters and battering storm surges by building fortifications such as the sea walls planned in Boston or Miami. Or people can figure out how to live…
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Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations [Biophysics and Computational Biology]
The voltage-gated Hv1 proton channel is a ubiquitous membrane protein that has roles in a variety of cellular processes, including proton extrusion, pH regulation, production of reactive oxygen species, proliferation of cancer cells, and increased brain damage during ischemic stroke. A crystal structure of an Hv1 construct in a putative…
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The thermo-wetting instability driving Leidenfrost film collapse [Engineering]
Above a critical temperature known as the Leidenfrost point (LFP), a heated surface can suspend a liquid droplet above a film of its own vapor. The insulating vapor film can be highly detrimental in metallurgical quenching and thermal control of electronic devices, but may also be harnessed to reduce drag…
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Earth and field observations underpin metapopulation dynamics in complex landscapes: Near-term study on carabids [Ecology]
Understanding risks to biodiversity requires predictions of the spatial distribution of species adapting to changing ecosystems and, to that end, Earth observations integrating field surveys prove essential as they provide key numbers for assessing landscape-wide biodiversity scenarios. Here, we develop, and apply to a relevant case study, a method suited…
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Colorful Corals Beat Bleaching
Exposed to mildly warmer waters, some corals turn neon instead of bleaching white. The dramatic colors may help coax symbiotic algae back. Christopher Intagliata reports. — Read more on ScientificAmerican.com
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Colorful Corals Beat Bleaching
Exposed to mildly warmer waters, some corals turn neon instead of bleaching white. The dramatic colors may help coax symbiotic algae back. Christopher Intagliata reports. — Read more on ScientificAmerican.com
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The Atlantic Daily: Elon Musk Comes Within 20 Minutes of History
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox . NISRINE LA "That was one hell of a dress rehearsal." That's the reaction of our space reporter Marina Koren, upon hearing the news that today's historic SpaceX launch would be postponed—just 17 m
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France Bans a Malaria Drug From Coronavirus Treatments: Live Coverage
Nissan and Renault and trying to reset their troubled relationship. An E.U. recovery plan could bring the bloc closer to a shared budget.
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on the Four Months After First Case, U.S. Death Toll Passes 100,000
Scientists are revising the timeline of how the virus spread. Education Secretary Betsy DeVos said she would direct public school districts to share federal aid with private schools.
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Coronavirus live news: Trump criticised over 'preventable' crisis as US passes 100,000 deaths
61 Tory MPs defy UK PM over Dominic Cummings lockdown breach; European commission proposes €750bn coronavirus recovery fund; Kenya records highest one-day case rise. Follow the latest updates Global report: EU countries block hydroxychloroquine, South Korea fears new spike US passes 100,000 coronavirus deaths as states relax lockdown measures Tory anger at Dominic Cummings grows as 61 MPs defy Bo
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A bio-inspired addition to concrete stops the damage caused by freezing and thawing
Concrete is one of the most durable building materials used in modern-day infrastructures, but it has a weakness — ice — which can cause it to crumble. Now, inspired by organisms that survive in sub-zero environments, researchers are introducing polymer molecules with anti-freezing abilities into concrete.
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Physicists measure a short-lived radioactive molecule for first time
Researchers have combined the power of a super collider with techniques of laser spectroscopy to precisely measure a short-lived radioactive molecule, radium monofluoride, for the first time.
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Tuning the surface gives variations to metal foils
Researchers reported how to give variations to single crystalline metal foils. Via the oxidation-led annealing plus seeded growth strategy, they obtained over 30 types of copper foils the size of A4 paper, which is roughly the same size as US legal paper.
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How countries are using genomics to help avoid a second coronavirus wave
Nature, Published online: 27 May 2020; doi:10.1038/d41586-020-01573-5 Scientists in New Zealand, the United Kingdom and other places are using sequence data to track new infections as lockdowns ease.
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New understanding of RNA movements can be used to treat cancer
New research shows that an RNA molecule involved in preventing tumor formation can change its structure and thereby control protein production in the cell. The finding can have important clinical implications as it opens for new strategies to treat different types of cancer.
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In chimpanzees, females contribute to the protection of the territory
Researchers have extensively studied several neighboring groups of western chimpanzees and their findings reveal that females and even the entire group may play a more important role in between-group competition than previously thought. They found that even though adult males seem important in territory increase, territory maintenance and competitive advantage over neighbors act through the entire
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New linguistic findings on the prevalence of 'LOL'
A new study involving a scientific analysis of the prevalence of 'LOL' in students' text messages demonstrates important potential applications for classroom learning.
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Fishing less could be a win for both lobstermen and endangered whales
A new study found that New England's historic lobster fishery may turn a higher profit by operating with less gear in the water and a shorter season.
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Study finds a (much) earlier birth date for tectonic plates
Geophysicists reported that Earth's ever-shifting, underground network of tectonic plates was firmly in place more than 4 billion years ago — at least a billion years earlier than scientists generally thought.
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Under pressure, black holes feast
A new study shows that some supermassive black holes actually thrive under pressure. It has been known for some time that when distant galaxies — and the supermassive black holes within their cores — aggregate into clusters, these clusters create a volatile, highly pressurized environment. Individual galaxies falling into clusters are often deformed during the process and begin to resemble cosmi
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Where stress lives
Researchers have found a neural home of the feeling of stress people experience, an insight that may help people deal with the debilitating sense of fear and anxiety that stress can evoke.
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How do we disconnect from the environment during sleep and under anesthesia?
A series of new studies finds, among other important discoveries, that noradrenaline, a neurotransmitter secreted in response to stress, lies at the heart of our ability to "shut off" our sensory responses and sleep soundly.
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A bio-inspired addition to concrete stops the damage caused by freezing and thawing
Concrete is one of the most durable building materials used in modern-day infrastructures, but it has a weakness — ice — which can cause it to crumble. Now, inspired by organisms that survive in sub-zero environments, researchers are introducing polymer molecules with anti-freezing abilities into concrete.
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Physicists measure a short-lived radioactive molecule for first time
Researchers have combined the power of a super collider with techniques of laser spectroscopy to precisely measure a short-lived radioactive molecule, radium monofluoride, for the first time.
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Tuning the surface gives variations to metal foils
Researchers reported how to give variations to single crystalline metal foils. Via the oxidation-led annealing plus seeded growth strategy, they obtained over 30 types of copper foils the size of A4 paper, which is roughly the same size as US legal paper.
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What does the red pill really show you?
The "red pill" came into prominence as a way to break free of mental slavery in the 1999 movie, "The Matrix." In a new essay, Julian Walker points out Neo's powers only worked inside of the simulation—reality is a different story. The red vs blue pill question is a pop culture phenomenon, often used in questionable circumstances. Pop culture always translates strangely, though it appears we've hi
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Airborne science discovers complex geomorphic controls on Bornean forests
Using tree chemistry maps, high-resolution topography data, and computer models, researchers have uncovered new insights into the processes behind how life coevolved with our planet.
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Women's health services adapting well to COVID-19, but concerns remain for long-term
The majority of women's healthcare units in the UK, including services such as maternity and gynaecological cancers, have adapted well to the initial COVID-19 outbreak, according to a new survey by University of Warwick researchers.
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COVID-19 vaccine development: New guidelines for ethical approach to infecting trial volunteers
Allowing consenting volunteers to be deliberately infected with COVID-19 for the purposes of developing a vaccine could be done ethically and potentially speed up its development, a University of Warwick researcher has argued in new research.
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Listen: It's a Small World Health Organization
On this episode of Social Distance , James Hamblin and Katherine Wells talk with Kelley Lee, a professor of public health at Simon Fraser University, about the history, necessity, and vulnerability of the World Health Organization. Listen to the episode here: Subscribe to Social Distance on Apple Podcasts , Spotify , or another podcast platform to receive new episodes as soon as they're published
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Optimal time to treat Huntington's disease identified
The earliest brain changes due to Huntington's disease can be detected 24 years before clinical symptoms show, according to a new study.
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1ST COVID autopsy series by LSUHealthNO pathologists reveals new cardiopulmonary findings
LSU Health New Orleans pathologists performed the first series of autopsies on African Americans who died from COVID-19 in New Orleans, and their findings provide new and critical information to guide patient management. The findings are published in The Lancet Respiratory Medicine.
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Prevalence of 'silent' COVID-19 infection may be much higher than thought
The prevalence of 'silent' symptomless COVID-19 infection may be much higher than thought, reveals a study charting the enforced isolation of cruise ship passengers during the current pandemic, and published online in the journal Thorax.
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How Will We Remember the Coronavirus Pandemic?
Years later, our memories of the pandemic may be somewhat distorted because of the way our brain processes emotions and events.
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Larry Kramer, Aids activist, dies at age 84
New York playwright prodded an often unwilling nation to confront public health crisis
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SpaceX Launch of NASA Astronauts Is Postponed Over Weather
Persistent clouds did not clear in time, pushing the launch back to either Saturday or Sunday, the next window of opportunity.
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Author Correction: Role of HDAC9-FoxO1 Axis in the Transcriptional Program Associated with Hepatic Gluconeogenesis
Scientific Reports, Published online: 28 May 2020; doi:10.1038/s41598-020-66085-8
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Author Correction: Challenges in the serological evaluation of dogs clinically suspect for canine leishmaniasis
Scientific Reports, Published online: 28 May 2020; doi:10.1038/s41598-020-66088-5
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Author Correction: Identification of a binding protein for sesamin and characterization of its roles in plant growth
Scientific Reports, Published online: 28 May 2020; doi:10.1038/s41598-020-66086-7
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Author Correction: A complete catalogue of high-quality topological materials
Nature, Published online: 28 May 2020; doi:10.1038/s41586-020-2304-y
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Author Correction: Additive manufacturing of ultrafine-grained high-strength titanium alloys
Nature, Published online: 28 May 2020; doi:10.1038/s41586-020-2291-z
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Migratory birds in the Eastern US are struggling to adapt to climate change
A male Indigo Bunting (Passerina cyanea) perches atop a sunflower. In recent decades, many bird species have become less abundant across North America. (Steve Rushing/) Migratory birds may be particularly vulnerable to the impacts of climate change compared with birds that stay put during the winter, scientists reported May 26 in Proceedings of the National Academy of Sciences . The researchers f
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Didier Raoult: Fin de Partie?
As chloroquine miracle cure for COVID-19 is discredited by day, what will become of its inventor, Didier Raoult?
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Women and minorities lacking in research and clinical trials for new cardiometabolic medications
Women and minorities have low participation rates in pivotal trials for new medications. 10-year analysis of clinical trial data reveals no improvement in diversity over time. Further efforts are needed to determine differences in medication effects among demographic subgroups.
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Search-and-rescue algorithm identifies hidden'traps' in ocean waters
Researchers at MIT, the Swiss Federal Institute of Technology (ETH), the Woods Hole Oceanographic Institution (WHOI), and Virginia Tech have developed a technique that they hope will help first responders quickly zero in on regions of the sea where missing objects or people are likely to be.
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What the growing rift between the US and WHO means for COVID-19 and global health
Nature, Published online: 27 May 2020; doi:10.1038/d41586-020-01586-0 If President Trump sidelines the World Health Organization, experts foresee incoherence, inefficiency and resurgence of deadly diseases.
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Medical Groups Ask FDA To Ease Access To Abortion Pill During The Pandemic
Reproductive rights advocates want patients to be allowed to pick up mifepristone at a hospital or clinic. The drug, which was approved 20 years ago, also helps to manage miscarriages for some women. (Image credit: OLIVIER DOULIERY/AFP via Getty Images)
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Can plasma from COVID-19 survivors help save others?
Small studies suggest transfusions with antibody-laden blood plasma may help patients fight the virus
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Study shows domestic violence reports on the rise as COVID-19 keeps people at home
A UCLA-led research team has found an increase in domestic violence reports in Los Angeles and Indianapolis since the stay-at-home restrictions were implemented in March. The scholars, who are leaders in applying mathematics to interpret and make sense of police crime data, predict the incidence should gradually decrease as people return to normal routines, but would likely increase again if there
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Human growth hormone treatment after ACL injury may prevent loss of muscle strength
A new study finds the use of HGH treatment in patients that have undergone ACL reconstructive surgery may prevent the loss of muscle strength and weakness.
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Low vaccination rates and 'measles parties' fueled 2019 measles outbreak in NYC
An analysis of the 2018-2019 measles outbreak in New York City identifies factors that made the outbreak so severe: delayed vaccination of young children combined with increased contact among this age group, likely through "measles parties" designed to purposely infect children. The study has implications for the future, as vaccination rates plummet during the COVID-19 pandemic.
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Gene inactivation of PTEN drives cancer predisposition
An international team of researchers co-led by Cleveland Clinic have identified why patients without PTEN mutations may still experience the high cancer risk associated with PTEN hamartoma tumor syndrome.In a new study published in the New England Journal of Medicine, a research team co-led by Drs. Charis Eng, Cleveland Clinic Genomic Medicine Institute, and Pier Paolo Pandolfi, University of Turi
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Evolution Is the Greatest Show on Earth – Issue 85: Reopening
Science can be a peculiar source of joy—the joy, largely unique to human beings, of understanding the universe in which we live. For some, the joys of science are readily accessible; they get hooked on it as children, then get to enjoy a regular fix of science for the rest of their lives. For others, though, it's not so easy. Many people could get hooked on science, but for one reason or another
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Young and Healthy and Waiting to Get Cancer – Issue 85: Reopening
I'm young and perfectly healthy, but I'm waiting for the day when I finally get sick. While many of us are locked down in our homes due to the coronavirus pandemic, it may feel like the world is currently sharing a collective period of waiting. However, I'm not waiting for sickness from a virus. I am waiting to find a lump. I am waiting for my test results. I am waiting to elect to remove my brea
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No Country for Old People – Issue 85: Reopening
Sweden did not set out to kill thousands of its older citizens. Nor did any country as COVID-19 swept across the globe. But Sweden's unique and closely watched approach to the pandemic has spotlighted the tragic toll the coronavirus has taken on the elderly. It has cast a harsh light on the value that societies have placed on the freedoms of some to the expense of others. In March, when many Euro
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Mice on Acid – Issue 85: Reopening
In the bowels of an animal research facility at Oxford University, mice are stirring in cages. Half of them have been given an injection of saline solution and behave like the docile house pet of your local fifth-grader. The other half have been given DOI, a drug chemically similar to LSD, and are, as the term of art would have it, tripping balls. What exactly a mouse sees when she's tripping on
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The mystery of moving, mossy, 'glacier mice'
Weird but cute, "glacier mice" are actually balls of moss, dirt, and more. The balls move, oddly, in packs through some unknown means. A new study tracked 30 glacier mice but still couldn't figure out what's going on. Scientists have known about them at least since the 1950s, when Jón Eythórsson named them "jökla-mýs," which translates as "glacier mice." However, they're not actually mice. They'r
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States Sue to Block Trump From Weakening Fuel Economy Rules
At stake in the lawsuit is the single biggest effort by the United States to fight the climate crisis.
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How to Become an In-Demand Ethical Hacker in 2020
In 2018, 14 million people were victims of identity fraud , and that's just in the US. As our lives shift more online, identity theft, record breaches, and other crimes are becoming more commonplace. In turn, that means there's a rising demand for white-hat hackers, the security experts and penetration testers dedicated to keeping cybercriminals at bay, and it's never been easier to join their ra
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Seeing the Unseen: The Art of Microscopy
Download this eBook to learn how works of art are advancing research!
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Ear infections discovered in remains of humans living in Levant 15,000 years ago
Researchers have discovered evidence of ear infections in the skull remains of humans living in the Levant some 15,000 years ago.
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Substantial quantities of tire particles contaminating rivers and ocean
Research reveals vital new information that will improve our scientific understanding of how tiny particles from tires, synthetic fibers from clothing and maritime gear enter the ocean.
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Scientists reveal new fundamental principles governing diving in animals
An international team of scientists has examined how metabolic constraints govern the diving performance of air-breathing aquatic species, all of which have evolved to maximise the amount of time they can spend underwater.
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Finding working capital is key to small businesses efforts as reopening accelerates
Small businesses are suffering affer a long pandemic shutdown and they are worried about what will be needed as they begin to reopen. Interviews with a select group of small business owners found that access to working capital is key to reopening, as well as clear guidance from government or trade organizations about how to reopen safely during the pandemic.
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What's the secret behind the world's stickiest brands?
Researchers from Newcastle University London, Fordham University, and University of Minho published a new paper in the Journal of Marketing that examines how some brands create "sticky" customer journeys that keep customers addicted.
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Historic SpaceX launch postponed because of stormy weather
The launch of a SpaceX rocket ship with two NASA astronauts on a history-making flight into orbit has been called off with 16 minutes to go in the countdown because of the danger of lightning.
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Device simulates filtering and ion transport functions of human kidney
University of Arkansas researchers have developed a device that simulates the blood filtering and ion transport functions of the human kidney. The technology could transform treatment options for people in the final stage of renal disease.
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An exploratory study of metformin and rapamycin as maintenance therapy
Volume 11, Number 21 of @Oncotarget reported that eligible patients with stable or responding mPDA after 6 months on chemotherapy were randomized 1:1 to metformin alone or with rapamycin, stratified by prior treatment with FOLFIRINOX. Metformin +/ rapamycin maintenance for mPDA was well-tolerated and several patients achieved stable disease associated with exceptionally long survival.
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School closures may boost childhood obesity
The childhood obesity rate in the United States may increase 2.4% if school closures continue into December, according to a new study. "Having schools closed nationwide, children in the US have missed their opportunity to participate in physical education classes and other school-based physical activities, such as recess and after-school sports programs," says Ruopeng An, assistant professor at t
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Cannibal dinosaurs resorted to eating each other when food was scarce
Bite marks on a collection of Jurassic dinosaur bones show that allosaurus, a carnivorous dinosaur, sometimes ate its own kind, possibly because environmental conditions made other food scarce
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Breaking: SpaceX Scrubs Historic Launch Due to Bad Weather
SpaceX and NASA had to scrub their historic launch to the International Space Station this afternoon due to bad weather . Officials deemed the weather to be unsafe for liftoff with just 16 minutes left on the countdown. Standing down from launch today due to unfavorable weather in the flight path. Our next launch opportunity is Saturday, May 30 at 3:22 p.m. EDT, or 19:22 UTC — SpaceX (@SpaceX) Ma
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Weather Delays the SpaceX Crew Dragon Launch
The historic launch planned for Wednesday gets pushed back due to stormy conditions, but the launch window remains open. SpaceX and NASA will try again Saturday.
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SpaceX launch cancelled due to bad weather – as it happened
Thunder and lightning in the area may have contributed to the mission scrub which will have another opportunity on Saturday 9.47pm BST PS: the crew will now return to pre-flight quarantine for the safety of the International Space Station and its onboard crew. 9.44pm BST Thank you very much for following along even if that was, possibly, a record short Guardian US live blog, in the circumstances.
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New evidence for a blood-based biomarker for Alzheimer's disease
Neurofilament light chain (NfL) has great potential as a biomarker for early detection of Alzheimer's disease and could be also useful for monitoring treatment response for that condition.
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COVID-19 news from Annals of Internal Medicine
1. Risk for COVID-19 Resurgence Related to Duration and Effectiveness of Physical Distancing in Ontario, Canada 2. Use of Hydroxychloroquine or Chloroquine in COVID-19
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'Knowing how' is in your brain
A new study has found the brain programs that code the sequence of steps in performing a complex procedure.
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Pediatric scoring scale helps surgeons decide whether to operate during COVID-19 delays
As health care providers observe Coronavirus Disease 2019 (COVID-19) affecting children differently than adults, pediatric surgeons in Chicago have modified an evaluation tool for use in pediatric patients that allows surgeons in every pediatric specialty to prioritize nonemergency ('elective') operations during all phases of the pandemic. The new pediatric-specific scoring system is presented in
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Biomarkers may help us understand recovery time after concussion
A blood test may help researchers understand which people may take years to recover from concussion, according to a study published in the May 27, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology.
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A glass half-full view built on stimulus efforts succeeding
Mike Mackenzie's daily analysis of what's moving global markets
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Mexico's GDP could fall nearly 9% in 2020
Central bank's predictions at odds with rosier forecast from President Andrés Manuel López Obrador
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New Data Show The Coronavirus Is Less Lethal Than First Thought
Scientists have found evidence that the coronavirus is less deadly than it first appeared — for Americans infected with the coronavirus, the chance of dying appears to be less than 1 in 100.
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Coronavirus Epidemics Began Later Than Believed, Study Concludes
In Washington State and Italy, the first confirmed cases were not linked to the outbreaks that followed, the analysis found. The epidemics were seeded later.
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Caveolin binding motif in Na/K-ATPase is required for stem cell differentiation, organogenesis in animals
New findings reveal the importance of the Na/K-ATPase protein in stem cell differentiation and organogenesis, in a study led by scientists at Marshall University that involves the scaffolding function of the Na/K-ATPase.
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Caveolin binding motif in Na/K-ATPase is required for stem cell differentiation, organogenesis in animals
New findings reveal the importance of the Na/K-ATPase protein in stem cell differentiation and organogenesis, in a study led by scientists at Marshall University that involves the scaffolding function of the Na/K-ATPase.
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Brain scans reveal the source of stress in the brain
Researchers have found a home in the brain for the feeling of stress. The new research may help people deal with the debilitating sense of fear and anxiety that stress can evoke, researchers report. Brain scans of people exposed to highly stressful and troubling images—such as a snarling dog, mutilated faces, or filthy toilets—reveal a network of neural connections emanating throughout the brain
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App weighs risks of cancer treatment delay during COVID-19
A new app compares the long-term risks of delaying treatment for cancer patients during the COVID-19 pandemic to the risk of potential infection if someone undergoes surgery, chemotherapy, and/or radiation. As the COVID-19 pandemic has overwhelmed health care systems across the country, doctors have postponed surgery and other treatments for thousands of patients with cancer. These delays may las
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What's the secret behind the world's stickiest brands?
Sticky customer journeys do not arise from consistently good customer experiences — instead, they are intentionally chaotic, maddening, and unpredictable.
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June's SLAS Technology highlights papers authored by SLAS2019 Ignite award winner
The June issue of SLAS Technology features two related research papers authored by Georges Muller, Ph.D., (SEED Biosciences, Switzerland) the SLAS2019 Ignite Award winner and a top ten 2020 SLAS Innovation Award finalist.
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First US Outbreak of COVID-19 Seeded in Mid-February: Preprint
A modeling study counters initial interpretations that the cluster began with someone who flew to Seattle in mid-January.
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So, What Can We Do Now?
Editor's Note: The Atlantic is making vital coverage of the coronavirus available to all readers. Find the collection here . Staying at home for months is an onerous thing to ask of people, but what it means is easy enough to understand: Unless necessary to keep your job or keep yourself alive, you just don't leave. When American mayors and governors began asking people to shelter in place to com
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The next era of space travel should include nuclear-powered rockets
A SpaceX rocket seen launching from Cape Canaveral in Florida. (SpaceX/) Iain Boyd is a professor of Aerospace Engineering Sciences at the University of Colorado Boulder. This story originally featured on The Conversation . With dreams of Mars on the minds of both NASA and Elon Musk , long-distance crewed missions through space are coming. But you might be surprised to learn that modern rockets d
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Ice tea makers that will refresh you on hot days
Simply tea-licious. (Matt Hoffman via Unsplash/) In a world obsessed with coffee, tea connoiseurs can feel left out in the cold. Iced tea requires an infusion of hot liquid at just the right temperature for just the right time before chilling, or it can be cold-brewed, but it's far more complex than sticking a bag in some water. The best iced tea makers offer quality filters for everything from d
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Ford Software Update Lets Cop Cars Bake Away Coronavirus
Heat Soak Ford is trying something different to keep its lineup of Police Interceptor Utility vehicles sanitary in a global pandemic. A new software update, called "Interior Cabin Heat Soak," allows the vehicles to heat their interior cabins to neutralize any infected surfaces, The Drive reports . Easy Bake The heating system on Ford vehicles isn't powerful enough, so the system redirects hot coo
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June's SLAS discovery features the special collection, 'ion channels and relevant drug screening approaches'
In this issue, Guest Editor Veli-Pekka Jaakola, Ph.D., (Confo Therapeutics, Belgium) highlights a series of articles focused on new screening tools and assays that find new chemical matter for medically relevant membrane protein targets
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Caveolin binding motif in Na/K-ATPase required for stem cell differentiation in animals
New findings reveal the importance of the Na/K-ATPase protein in stem cell differentiation and organogenesis, in a study led by scientists at Marshall University that involves the scaffolding function of the Na/K-ATPase.
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Study investigates Atlantic Rainforest regeneration in the state of São Paulo
The same procedure will be extended to the entire Atlantic Rainforest biome, remnants of which are located on the coast of 17 Brazilian states.
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Giant eruptions belched toxic metal during the 'Great Dying'
Nature, Published online: 27 May 2020; doi:10.1038/d41586-020-01576-2 Volcanoes in Siberia poisoned the planet with mercury, contributing to a global mass extinction.
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How to Recover From Covid-19 at Home
Rest and fluids are essential, but not always enough. Here are some more things you can do to feel better.
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Aid for UK self-employed in doubt despite pledge of 'parity' with furloughing
Fears scheme which has paid out £6.8bn will not be extended alongside support to companies for their employees
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How to raise kids who can overcome anxiety | Anne Marie Albano
Growing up means facing new challenges — but for some kids, uncertain situations lead to anxiety that parents often seek to soothe. Psychologist Anne Marie Albano explains how constantly rushing to fix a child's problems can perpetuate a lifelong cycle of dependence and resentment — and shares why a healthy dose of risk helps kids cultivate lasting confidence.
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Refusing to Wear a Mask Is an Empty Act of Defiance
The woman in the video would like you to know that she is compassionate. She would like you to know that she understands "the virus is real." She would also like you to know, however, that she has tried wearing a face mask while out in public during the coronavirus pandemic, and that she will not be wearing one again. "I'm at the end of it," she says tearfully, recording herself in her car after
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New study evaluates facial feminization outcomes, benefits for transgender women
Previous studies have reported improved quality of life and mental health in transgender women undergoing facial feminization surgery (FFS) surgery to provide a more feminine facial appearance. But there is still limited evidence on these and other benefits of facial gender confirmation surgery.
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This Video of Mars' Leaking Atmosphere Could Make Elon Musk Cry
Blowing Away A new stunning set of NASA animations reveal how the Sun is slowly stripping away the Red Planet's atmosphere. The animations, created from data gathered by NASA's MAVEN spacecraft as it orbited Mars, show that Mars' magnetosphere is too weak to protect the planet from harsh solar winds that have gradually blown away much of its atmosphere, Inverse reports . The new animation also pr
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Designing a flexible material to protect buildings, military personnel
Shake, rattle and roll. Even though they are miles from the epicenter of an earthquake, buildings can collapse due to how an earthquake energy makes the ground shake and rattle. Now, a team of engineers has designed a flexible material that can help buildings withstand multiple waves of energy traveling through a solid material, including the simultaneous forward and backward and side-to-side moti
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Return of the Blob: Surprise link found to edge turbulence in fusion plasma
Correlation discovered between magnetic turbulence in fusion plasmas and troublesome blobs at the plasma edge.
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CNN Is Picking Ratings Over Ethics
America doesn't have a hereditary aristocracy—it just has members of the same families who occupy powerful positions from generation to generation. Consider the Cuomo family. Mario, the patriarch, rose from humble circumstances in Queens to become the governor of New York. One of his sons, Andrew, now fills the same job; Andrew's younger brother, Chris, is a high-profile CNN anchor. For a time ye
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Carnivorous Dinosaurs Like Allosaurus Were Cannibals
Tooth-marked bones show that huge flesh-eaters had no qualms about chomping their own kind when times got tough
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Modern problems, primitive solutions: A glimpse into archaic protein synthesis systems
The interaction between 'transfer RNAs' and the enzymes that help them in protein synthesis has always been the key area of interest for understanding the evolution of the genetic code. Now, a team of scientists reports that a subunit of 'alanyl-tRNA synthetase' enzyme of the primitive microorganism Nanoarchaeum equitans can mimic the super-primitive tRNA 'aminoacylation' independent of the presen
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More effective human antibodies possible with chicken cells
Antibodies for potential use as medicines can be made rapidly in chicken cells grown in laboratories. Researchers refer to their technique as the human ADLib system, short for autonomously diversifying libraries. The technique automatically builds vast numbers, or libraries, of diverse antibodies using chicken immune system cells' natural method for shuffling their genes.
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Terrestrial bacteria can grow on nutrients from space
As inevitable fellow travellers on the bodies of astronauts, spaceships, or equipment, terrestrial microorganisms will undoubtedly come into contact with extraterrestrial environments. Researchers now describe how bacteria can survive on an 'extraterrestrial diet', which affected their pathogenic potential.
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Coronavirus Isn't Keeping Florida Crowds From SpaceX Launch
Many beachside hotels along the state's Space Coast were already at capacity before Wednesday's scheduled launch, a local tourism executive said.
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Augmented reality can improve online shopping, study finds
A recent survey found that online shoppers return 70% of the clothing they order, more than any other category of purchase. This has an indirect but real impact on the environment.
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Tesla Slashes Prices By Up to $5,000 on Almost Every Vehicle Line
Tesla has cut its prices on multiple models, with price cuts of up to $5,000 on specific vehicles. The cuts may be an attempt to stimulate demand after the pandemic, but Tesla hasn't announced an official rationale. First up, the Standard Range Plus variant of the Model 3 has picked up a $2,000 price cut, dropping from $39,990 to $37,990. The Model S Long Range Plus is now $74,990, a $5,000 reduc
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These tiny, self-assembling traps capture PFAS
University at Buffalo chemists have shown that self-assembling molecular traps can be used to capture PFAS—dangerous pollutants that have contaminated drinking water supplies around the world.
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Computer vision and uncertainty in AI for robotic prosthetics
Researchers have developed new software that can be integrated with existing hardware to enable people using robotic prosthetics or exoskeletons to walk in a safer, more natural manner on different types of terrain. The new framework incorporates computer vision into prosthetic leg control, and includes robust artificial intelligence (AI) algorithms that allow the software to better account for un
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More effective human antibodies possible with chicken cells
Antibodies for potential use as medicines can be made rapidly in chicken cells grown in laboratories. Researchers refer to their technique as the human ADLib system, short for autonomously diversifying libraries. The technique automatically builds vast numbers, or libraries, of diverse antibodies using chicken immune system cells' natural method for shuffling their genes.
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Computer vision and uncertainty in AI for robotic prosthetics
Researchers have developed new software that can be integrated with existing hardware to enable people using robotic prosthetics or exoskeletons to walk in a safer, more natural manner on different types of terrain. The new framework incorporates computer vision into prosthetic leg control, and includes robust artificial intelligence (AI) algorithms that allow the software to better account for un
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Circadian oscillation of a cyanobacterium doesn't need all three Kai proteins to keep going
Despite conventional understanding that three Kai proteins are required for the circadian oscillation of cyanobacteria, scientists discovered that even when one of them is destroyed, the oscillation is not completely abolished but instead damped. Further, they found that the damped rhythms resonate with external cycles of approximately 24 hours, which indicates that the natural frequency of the da
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Miniature rock art expands horizons
Archaeologists have discovered some of the most detailed examples of rare, small-scale rock art in the form of miniature stencils in a rockshelter traditionally owned by the Marra people. The research examined the unusual art found in the Yilbilinji rockshelter at Limmen National Park in the southwest Gulf of Carpentaria region of northern Australia.
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These tiny, self-assembling traps capture PFAS
A study shows that self-assembling molecular traps can be used to capture PFAS — dangerous pollutants that have contaminated drinking water supplies around the world.
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Covid-19 news: Boris Johnson admits UK was unprepared for pandemic
The latest coronavirus news updated every day including coronavirus cases, the latest news, features and interviews from New Scientist and essential information about the covid-19 pandemic
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Ultrasonic speakers let people who are blind read Braille in mid-air
People who are blind can read using a device that uses ultrasonic speakers to create points in mid-air similar to the dots that form Braille characters
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Boris Johnson rules out official Cummings inquiry
Backlash against aide continues with more Tory MPs seeking his dismissal and criticism from current and former ministers
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Scientists warn of 'zombie fires' in the Arctic
Dormant "zombie fires" scattered across the Arctic region—remnants of record blazes last year—may be coming to life after an unusually warm and dry Spring, scientists warned Wednesday.
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Canadian study of critically ill patients with COVID-19 found lower death rate
A Canadian case series of all patients with COVID-19 admitted to six intensive care units (ICUs) in Metro Vancouver found patient outcomes were substantially better than reported in other jurisdictions. The paper is published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/content/cmaj/early/2020/05/27/cmaj.200794.full.pdf.
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Loss of smell, taste changes associated with COVID-19: Canadian study
Loss of smell (anosmia) and changes in taste (dysgeusia) were strongly associated with SARS-CoV-2, according to a Canadian study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/content/early/2020/05/27/cmaj.200869.
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Masks reduce airborne transmission of SARS-CoV-2
Growing evidence suggests that SARS-CoV-2, the novel coronavirus that causes COVID-19, can be spread by asymptomatic people via aerosols — a reality that deeply underscores the ongoing importance of regular widespread testing, wearing masks and physical distancing to reduce the spread of the virus, say Kimberly Prather and colleagues in a new Perspective.
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As businesses reopen, it's crucial we wear masks, safely distance
In a perspective piece published today in the journal Science, UC San Diego experts describe in detail the growing evidence that SARS-CoV-2, the novel coronavirus that causes COVID-19, can be spread by asymptomatic people via aerosols — a reality that deeply underscores the ongoing importance of regular widespread testing, wearing masks and physical distancing to reduce the spread of the virus.
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Same father, same face
Artificial intelligence reveals mechanism for kin selection in a wild primate.
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Electronic cigarettes trigger an inflammatory response that may set the stage for gum disease
The oral microbiomes of 25 otherwise healthy participants who use e-cigarettes daily closely match those seen in patients with gum disease, a new study shows. The results suggest that e-cigarettes trigger a proinflammatory response, coating commensal bacteria in the mouth with a layer of slime that makes them unrecognizable to the body and prevents the
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A potential explanation for urban smog
The effect of nitric acid on aerosol particles in the atmosphere may offer an explanation for the smog seen engulfing cities on frosty days.
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Study shows erosion of ozone layer responsible for mass extinction event
Researchers at the University of Southampton have shown that an extinction event 360 million years ago, that killed much of the Earth's plant and freshwater aquatic life, was caused by a brief breakdown of the ozone layer that shields the Earth from damaging ultraviolet (UV) radiation. This is a newly discovered extinction mechanism with profound implications for our warming world today.
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New clues to deep earthquake mystery
A new understanding of our planet's deepest earthquakes could help unravel one of the most mysterious geophysical processes on Earth.
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A few months of vaping puts healthy people on the brink of oral disease
The collection of oral bacteria in daily e-cigarette users' mouths is teeming with potent infection-causing organisms that put vapers at substantial risk for ailments ranging from gum disease to cancer, researchers found.
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Study finds TAVR is safe treatment for patients with bicuspid valve disease
For many patients with a bicuspid aortic valve that needs replacing, transcatheter aortic valve replacement (TAVR) appears to be a safe treatment option with low complication rates, according to a study published in JACC: Cardiovascular Interventions. The study found patients with bicuspid valves who were at increased risk for surgery had a 30-day and one-year mortality rate and stroke rate that w
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Initial Upper Paleolithic technology reached North China by ~41,000 years ago
A wave of new technology in the Late Paleolithic had reached North China by around 41,000 years ago, according to a study published May 27, 2020, in the open-access journal PLOS ONE by Fei Peng of the Minzu University of China, Beijing and colleagues.
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An analysis of psychological meta-analyses reveals a reproducibility problem
Meta-analysis research studies in psychology aren't always reproducible due to a lack of transparency of reporting in the meta-analysis process, according to a new study published May 27, 2020, in the open-access journal PLOS ONE by Esther Maassen of Tilburg University, the Netherlands, and colleagues.
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Exploring the use of 'stretchable' words in social media
An investigation of Twitter messages reveals new insights and tools for studying how people use stretched words, such as 'duuuuude,' 'heyyyyy,' or 'noooooooo.' Tyler Gray and colleagues at the University of Vermont in Burlington present these findings in the open-access journal PLOS ONE on May 27, 2020.
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In stressed ecosystems Jurassic dinosaurs turned to scavenging, maybe even cannibalism
Among dinosaurs of ancient Colorado, scavenging and possibly cannibalism were responses to a resource-scarce environment, according to a study published May 27, 2020, in the open-access journal PLOS ONE by Stephanie Drumheller of the University of Tennessee, Knoxville, and colleagues.
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Six common photography mistakes to avoid
There's nothing necessarily wrong with this photo, but if you get comfortable with a certain photography style (such as portraits), it can be hard to branch out. (Harry Guinness /) Taking great photos is hard work and it's easy to make the same mistakes again and again. And as soon as you start overcoming one set of mistakes, you start making new ones. I've been at it for more than a decade and I
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2 U.S. astronauts arrive at launch pad for SpaceX launch
With thunderstorms and the possibility of tornadoes threatening a delay, two NASA astronauts climbed aboard a SpaceX rocket ship Wednesday for liftoff on a history-making flight that was seen as a giant leap forward for the booming business of commercial space travel.
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Coal's Decline Continues with 13 Plant Closures Announced in 2020
The fuel is increasingly uncompetitive with cheaper natural gas and renewable energy — Read more on ScientificAmerican.com
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We can see when your brain forms a memory by watching you move
Subtle patterns can be seen in people's reaction times as their memories are recalled, and boosting these brainwaves could help treat Alzheimer's disease
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Genomic analysis in samples of Neanderthals and modern humans shows a decrease in ADHD-associated genetic variants
The frequency of genetic variants associated with attention-deficit/hyperactivity disorder (ADHD) has decreased progressively in the evolutionary human lineage from the Paleolithic to the present day, according to new research.
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Allosaurus dinosaur suspected to be scavenging cannibal
Dinosaur-on-dinosaur dining habit revealed by scrutiny of fossil bones from Colorado site About nine metres long, with grasping claws and a skull it used like a hatchet, Allosaurus was among the most fearsome dinosaurs of the Jurassic period. Now, it seems, the animal could also have been a cannibal. Fossil researchers have revealed that bite marks found in a cache of dinosaur bones from the Myga
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SpaceX-Nasa launch scrubbed due to poor weather
The first crewed flight from US soil since 2011 was called off 16 minutes before lift off; the next opportunity is on Saturday The United States' long-anticipated return to human spaceflight will have to wait a few more days after poor weather forced mission managers to scrub Wednesday's planned launch of a SpaceX Falcon 9 rocket from Florida. The first crewed flight from US soil since 2011 was c
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No asteroids needed: ancient mass extinction tied to ozone loss, warming climate
Malformed spores suggest powerful storms drove ozone loss and led to sterilizing UV radiation
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A caveolin binding motif in Na/K-ATPase is required for stem cell differentiation and organogenesis in mammals and C. elegans
Several signaling events have been recognized as essential for regulating cell lineage specification and organogenesis in animals. We find that the gain of an amino-terminal caveolin binding motif (CBM) in the α subunit of the Na/K–adenosine triphosphatase (ATPase) (NKA) is required for the early stages of organogenesis in both mice and Caenorhabditis elegans . The evolutionary gain of the CBM oc
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Optothermotronic effect as an ultrasensitive thermal sensing technology for solid-state electronics
The thermal excitation, regulation, and detection of charge carriers in solid-state electronics have attracted great attention toward high-performance sensing applications but still face major challenges. Manipulating thermal excitation and transport of charge carriers in nanoheterostructures, we report a giant temperature sensing effect in semiconductor nanofilms via optoelectronic coupling, ter
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Size-dependent influence of NOx on the growth rates of organic aerosol particles
Atmospheric new-particle formation (NPF) affects climate by contributing to a large fraction of the cloud condensation nuclei (CCN). Highly oxygenated organic molecules (HOMs) drive the early particle growth and therefore substantially influence the survival of newly formed particles to CCN. Nitrogen oxide (NO x ) is known to suppress the NPF driven by HOMs, but the underlying mechanism remains l
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Adverse effects of electronic cigarettes on the disease-naive oral microbiome
Six percent of Americans, including 3 million high schoolers, use e-cigarettes, which contain potentially toxic substances, volatile organic compounds, and metals. We present the first human study on the effects of e-cigarette exposure in the oral cavity. By interrogating both immunoinflammatory responses and microbial functional dynamics, we discovered pathogen overrepresentation, higher virulen
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Transmission dynamics of and insights from the 2018-2019 measles outbreak in New York City: A modeling study
In 2018–2019, New York City experienced the largest measles outbreak in the United States in nearly three decades. To identify key contributing factors, we modeled the transmission dynamics of this outbreak. Results indicate that delayed vaccination of 1- to 4-year-olds enabled the initial spread and that increased infectious contact, likely via "measles parties," facilitated later transmission.
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A biomimetic platelet based on assembling peptides initiates artificial coagulation
Platelets play a critical role in the regulation of coagulation, one of the essential processes in life, attracting great attention. However, mimicking platelets for in vivo artificial coagulation is still a great challenge due to the complexity of the process. Here, we design platelet-like nanoparticles (pNPs) based on self-assembled peptides that initiate coagulation and form clots in blood ves
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Phenotype stability under dynamic brain-tumor environment stimuli maps glioblastoma progression in patients
Although tumor invasiveness is known to drive glioblastoma (GBM) recurrence, current approaches to treatment assume a fairly simple GBM phenotype transition map. We provide new analyses to estimate the likelihood of reaching or remaining in a phenotype under dynamic, physiologically likely perturbations of stimuli ("phenotype stability"). We show that higher stability values of the motile phenoty
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Chemotaxis strategies of bacteria with multiple run modes
Bacterial chemotaxis—a fundamental example of directional navigation in the living world—is key to many biological processes, including the spreading of bacterial infections. Many bacterial species were recently reported to exhibit several distinct swimming modes—the flagella may, for example, push the cell body or wrap around it. How do the different run modes shape the chemotaxis strategy of a
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From asymmetrical to balanced genomic diversification during rediploidization: Subgenomic evolution in allotetraploid fish
A persistent enigma is the rarity of polyploidy in animals, compared to its prevalence in plants. Although animal polyploids are thought to experience deleterious genomic chaos during initial polyploidization and subsequent rediploidization processes, this hypothesis has not been tested. We provide an improved reference-quality de novo genome for allotetraploid goldfish whose origin dates to ~15
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Deep slab seismicity limited by rate of deformation in the transition zone
Deep earthquakes within subducting tectonic plates (slabs) are enigmatic because they appear similar to shallow earthquakes but must occur by a different mechanism. Previous attempts to explain the depth distribution of deep earthquakes in terms of the temperature at which possible triggering mechanisms are viable, fail to explain the spatial variability in seismicity. In addition to thermal cons
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Korean Genome Project: 1094 Korean personal genomes with clinical information
We present the initial phase of the Korean Genome Project (Korea1K), including 1094 whole genomes (sequenced at an average depth of 31 x ), along with data of 79 quantitative clinical traits. We identified 39 million single-nucleotide variants and indels of which half were singleton or doubleton and detected Korean-specific patterns based on several types of genomic variations. A genome-wide asso
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Kilohertz electron paramagnetic resonance spectroscopy of single nitrogen centers at zero magnetic field
Electron paramagnetic resonance (EPR) spectroscopy is among the most important analytical tools in physics, chemistry, and biology. The emergence of nitrogen-vacancy (NV) centers in diamond, serving as an atomic-sized magnetometer, has promoted this technique to single-spin level, even under ambient conditions. Despite the enormous progress in spatial resolution, the current megahertz spectral re
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Platelet-derived porous nanomotor for thrombus therapy
The treatment difficulties of venous thrombosis include short half-life, low utilization, and poor penetration of drugs at thrombus site. Here, we develop one kind of mesoporous/macroporous silica/platinum nanomotors with platelet membrane (PM) modification (MMNM/PM) for sequentially targeting delivery of thrombolytic and anticoagulant drugs for thrombus treatment. Regulated by the special protei
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Surface waves control bacterial attachment and formation of biofilms in thin layers
Formation of bacterial biofilms on solid surfaces within a fluid starts when bacteria attach to the substrate. Understanding environmental factors affecting the attachment and the early stages of the biofilm development will help develop methods of controlling the biofilm growth. Here, we show that biofilm formation is strongly affected by the flows in thin layers of bacterial suspensions control
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Structural basis of broad HIV neutralization by a vaccine-induced cow antibody
Potent broadly neutralizing antibodies (bnAbs) to HIV have been very challenging to elicit by vaccination in wild-type animals. Here, by x-ray crystallography, cryo–electron microscopy, and site-directed mutagenesis, we structurally and functionally elucidate the mode of binding of a potent bnAb (NC-Cow1) elicited in cows by immunization with the HIV envelope (Env) trimer BG505 SOSIP.664. The exc
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UV-B radiation was the Devonian-Carboniferous boundary terrestrial extinction kill mechanism
There is an unexplained terrestrial mass extinction at the Devonian-Carboniferous boundary (359 million years ago). The discovery in east Greenland of malformed land plant spores demonstrates that the extinction was coincident with elevated UV-B radiation demonstrating ozone layer reduction. Mercury data through the extinction level prove that, unlike other mass extinctions, there were no planeta
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Hydrous oceanic crust hosts megathrust creep at low shear stresses
The rheology of the metamorphosed oceanic crust may be a critical control on megathrust strength and deformation style. However, little is known about the strength and deformation style of metamorphosed basalt. Exhumed megathrust shear zones exposed on Kyushu, SW Japan, contain hydrous metabasalts deformed at temperatures between ~300° and ~500°C, spanning the inferred temperature-controlled seis
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Efficient communication over complex dynamical networks: The role of matrix non-normality
In both natural and engineered systems, communication often occurs dynamically over networks ranging from highly structured grids to largely disordered graphs. To use, or comprehend the use of, networks as efficient communication media requires understanding of how they propagate and transform information in the face of noise. Here, we develop a framework that enables us to examine how network st
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Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and fatal disease. However, IPF treatment has been limited by the low drug delivery efficiency to lungs and dysfunctional "injured" type II alveolar epithelial cell (AEC II). Here, we present surface-engineered nanoparticles (PER NPs) loading astaxanthin (AST) and trametinib (TRA) adhered to monocyte-derived multipotent cell (MOMC) for
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Same father, same face: Deep learning reveals selection for signaling kinship in a wild primate
Many animals rely on facial traits to recognize their kin; however, whether these traits have been selected specifically for this function remains unknown. Using deep learning for face recognition, we present the first evidence that interindividual facial resemblance has been selected to signal paternal kinship. Mandrills ( Mandrillus sphinx ) live in matrilineal societies, in which females spend
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Manipulating metals for adaptive thermal camouflage
Many species in nature have evolved remarkable strategies to visually adapt to the surroundings for the purpose of protection and predation. Similarly, acquiring the capabilities of adaptively camouflaging in the infrared (IR) spectrum has emerged as an intriguing but highly challenging technology in recent years. Here, we report adaptive thermal camouflage devices by bridging the optical and rad
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Feature-rich covalent stains for super-resolution and cleared tissue fluorescence microscopy
Fluorescence microscopy is a workhorse tool in biomedical imaging but often poses substantial challenges to practitioners in achieving bright or uniform labeling. In addition, while antibodies are effective specific labels, their reproducibility is often inconsistent, and they are difficult to use when staining thick specimens. We report the use of conventional, commercially available fluorescent
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ASPM-lexical tone association in speakers of a tone language: Direct evidence for the genetic-biasing hypothesis of language evolution
How language has evolved into more than 7000 varieties today remains a question that puzzles linguists, anthropologists, and evolutionary scientists. The genetic-biasing hypothesis of language evolution postulates that genes and language features coevolve, such that a population that is genetically predisposed to perceiving a particular linguistic feature would tend to adopt that feature in their
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Liquid seal for compact micropiston actuation at the capillary tip
Actuators at the tip of a submillimetric catheter could facilitate in vivo interventional procedures at cellular scales by enabling tissue biopsy and manipulation or supporting active micro-optics. However, the dominance of frictional forces at this scale makes classical mechanism problematic. Here, we report the design of a microscale piston, with a maximum dimension of 150 μm, fabricated with t
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High mantle seismic P-wave speeds as a signature for gravitational spreading of superplumes
New passive- and active-source seismic experiments reveal unusually high mantle P-wave speeds that extend beneath the remnants of the world's largest known large igneous province, making up the 120-million-year-old Ontong-Java-Manihiki-Hikurangi Plateau. Sub-Moho P n phases of ~8.8 ± 0.2 km/s are resolved with negligible azimuthal seismic anisotropy, but with strong radial anisotropy (~10%), char
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Fossil Bite Marks Show Some Dinosaurs Ate Their Own
Prehistoric remains also reveal signs of a particularly large predator. DinoScavengers.jpg Image credits: Brian Engh Rights information: CC BY: Redistribution permitted with credit Creature Wednesday, May 27, 2020 – 14:00 Joshua Learn, Contributor (Inside Science) — Some 152 million years ago, the Mygatt-Moore Quarry that now sits in present day western Colorado was as good a place to die as an
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Inside SpaceX's Crew Dragon Capsule | Space Launch LIVE
Take a look inside the Dragon Crew Capsule built by SpaceX. About Space Launch LIVE: Space Launch LIVE will cover the NASA launch of SpaceX's Crew Dragon capsule, which will carry veteran astronauts Bob Behnken and Doug Hurley to the International Space Station. Audiences can watch the launch on TV or stream it live on Discovery GO. They can also participate in the event by joining the conversati
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Artificial intelligence reveals mechanism for kin selection in a wild primate
More like mom or dad? Human babies always get this curious look on their face combined with the question whom the child resembles most. The answers vary depending on the degree of kinship, gender and the time of assessment. Mandrills, monkeys living in Equatorial Africa, may recognize facial features coding relatedness better than humans. Scientists at the German Primate Center—Leibniz Institute f
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Whoooaaa Duuuuude: Why We Stretch Words in Tweets and Texts
Notice you've been elongating your words lately? You're actually loading them with a whooooole lot of meaning.
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Surgeons study guidelines for treating cancer patients during pandemic
New research provides guidance on clinical decision-making in regards to treating pancreatic cancer patients during the COVID-19 pandemic.
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Avalanche photodiode breaks performance record for LiDAR receivers
Electrical and computer engineers have developed an avalanche photodiode that achieved record performance and has the potential to transform next generation night-vision imaging and Light Detection and Ranging (LiDAR) receivers. For LiDAR, the team's low-noise, two-micrometer avalanche photodiode enables higher-power operation that is eye-safe.
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Patterns in crop data reveal new insight about plants and their environments
A new study unearthed patterns in datasets collected on rice plants across Asia that allowed researchers to develop a matrix to predict the traits of rice plants depending on their genetics and environment. The approach could lead to better predictability in crop production.
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