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Comb of a lifetime: a new method for fluorescence microscopy
6dConventional fluorescence microscopy provides poor quantitative information of the sample because it only captures fluorescence intensity, which changes frequently and depends on external factors. Now, scientists have developed a new fluorescence microscopy technique to measure both fluorescence intensity and lifetime. Their method does not require mechanical scanning of a focal point; instead, it
Comb of a lifetime: a new method for fluorescence microscopy
6dConventional fluorescence microscopy provides poor quantitative information of the sample because it only captures fluorescence intensity, which changes frequently and depends on external factors. Now, scientists have developed a new fluorescence microscopy technique to measure both fluorescence intensity and lifetime. Their method does not require mechanical scanning of a focal point; instead, it
Covid variant spread rapidly in England even during lockdown, study finds
6dGovernment caves in to demands and closes all London primary schools in latest U-turn
Comb of a lifetime: a new method for fluorescence microscopy
6dConventional fluorescence microscopy provides poor quantitative information of the sample because it only captures fluorescence intensity, which changes frequently and depends on external factors. Now, scientists from Japan have developed a new fluorescence microscopy technique to measure both fluorescence intensity and lifetime. Their method does not require mechanical scanning of a focal point;
Nanoparticle drug-delivery system developed to treat brain disorders
6dTo facilitate successful delivery of therapeutic agents to the brain, a team of bioengineers, physicians, and collaborators at Brigham and Women's Hospital and Boston Children's Hospital created a nanoparticle platform, which can facilitate therapeutically effective delivery of encapsulated agents in mice with a physically breached or intact BBB. In a mouse model of traumatic brain injury (TBI), t
Putty-like composites of gallium metal with potential for real-world application
6dResearchers at the Institute for Basic Science (IBS) created a novel functional composite of gallium with putty or paste-like physical properties. The composite possesses excellent electromagnetic shielding properties as well as thermal conductivity.
Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice
6dProper formation of area identities of the cerebral cortex is crucial for cognitive functions and social behaviors of the brain. It remains largely unknown whether epigenetic mechanisms, including histone methylation, regulate cortical arealization. Here, we removed SETD2, the methyltransferase for histone 3 lysine-36 trimethylation (H3K36me3), in the developing dorsal forebrain in mice and showe
History of the solar nebula from meteorite paleomagnetism
6dWe review recent advances in our understanding of magnetism in the solar nebula and protoplanetary disks (PPDs). We discuss the implications of theory, meteorite measurements, and astronomical observations for planetary formation and nebular evolution. Paleomagnetic measurements indicate the presence of fields of 0.54 ± 0.21 G at ~1 to 3 astronomical units (AU) from the Sun and 0.06 G at 3 to 7 A
Ocean forcing drives glacier retreat in Greenland
6dThe retreat and acceleration of Greenland glaciers since the mid-1990s have been attributed to the enhanced intrusion of warm Atlantic Waters (AW) into fjords, but this assertion has not been quantitatively tested on a Greenland-wide basis or included in models. Here, we investigate how AW influenced retreat at 226 marine-terminating glaciers using ocean modeling, remote sensing, and in situ obse
Association of naturally occurring antibodies to {beta}-amyloid with cognitive decline and cerebral amyloidosis in Alzheimers disease
6dThe pathological relevance of naturally occurring antibodies to β-amyloid (NAbs-Aβ) in Alzheimer's disease (AD) remains unclear. We aimed to investigate their levels and associations with Aβ burden and cognitive decline in AD in a cross-sectional cohort from China and a longitudinal cohort from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. NAbs-Aβ levels in plasma and cerebrospin
Multidimensional coherent spectroscopy reveals triplet state coherences in cesium lead-halide perovskite nanocrystals
6dAdvances in optoelectronics require materials with novel and engineered characteristics. A class of materials that has garnered tremendous interest is metal-halide perovskites, stimulated by meteoric increases in photovoltaic efficiencies of perovskite solar cells. In addition, recent advances have applied perovskite nanocrystals (NCs) in light-emitting devices. It was found recently that, for ce
Fanconi anemia A protein participates in nucleolar homeostasis maintenance and ribosome biogenesis
6dFanconi anemia (FA), the most common inherited bone marrow failure and leukemia predisposition syndrome, is generally attributed to alterations in DNA damage responses due to the loss of function of the DNA repair and replication rescue activities of the FANC pathway. Here, we report that FANCA deficiency, whose inactivation has been identified in two-thirds of FA patients, is associated with nuc
MBD2 serves as a viable target against pulmonary fibrosis by inhibiting macrophage M2 program
6dDespite past extensive studies, the mechanisms underlying pulmonary fibrosis (PF) still remain poorly understood. Here, we demonstrated that lungs originating from different types of patients with PF, including coronavirus disease 2019, systemic sclerosis–associated interstitial lung disease, and idiopathic PF, and from mice following bleomycin (BLM)–induced PF are characterized by the altered me
Near-infrared oxidative phosphorylation inhibitor integrates acute myeloid leukemia-targeted imaging and therapy
6dAcute myeloid leukemia (AML) is a deadly hematological malignancy with frequent disease relapse. The biggest challenge for AML therapy is the lack of methods to target and kill the heterogeneous leukemia cells, which lead to disease relapse. Here, we describe a near-infrared (NIR) fluorescent dye, IR-26, which preferentially accumulates in the mitochondria of AML cells, depending on the hyperacti
Acoustofluidic centrifuge for nanoparticle enrichment and separation
6dLiquid droplets have been studied for decades and have recently experienced renewed attention as a simplified model for numerous fascinating physical phenomena occurring on size scales from the cell nucleus to stellar black holes. Here, we present an acoustofluidic centrifugation technique that leverages an entanglement of acoustic wave actuation and the spin of a fluidic droplet to enable nanopa
Synthetic lethality across normal tissues is strongly associated with cancer risk, onset, and tumor suppressor specificity
6dVarious characteristics of cancers exhibit tissue specificity, including lifetime cancer risk, onset age, and cancer driver genes. Previously, the large variation in cancer risk across human tissues was found to strongly correlate with the number of stem cell divisions and abnormal DNA methylation levels. Here, we study the role of synthetic lethality in cancer risk. Analyzing normal tissue trans
N6-methyldeoxyadenine and histone methylation mediate transgenerational survival advantages induced by hormetic heat stress
6dEnvironmental stress can induce survival advantages that are passed down to multiple generations, representing an evolutionarily advantageous adaptation at the species level. Using the nematode worm Caenorhabditis elegans as a model, we found that heat shock experienced in either parent could increase the longevity of themselves and up to the fifth generation of descendants. Mechanistic analyses
High-strength and fibrous capsule-resistant zwitterionic elastomers
6dThe high mechanical strength and long-term resistance to the fibrous capsule formation are two major challenges for implantable materials. Unfortunately, these two distinct properties do not come together and instead compromise each other. Here, we report a unique class of materials by integrating two weak zwitterionic hydrogels into an elastomer-like high-strength pure zwitterionic hydrogel via
Linking mobile money networks to "e-ROSCAs": An experimental study
6dWe present results from a study in the Democratic Republic of the Congo that uses mobile money networks to run rotating savings and credit associations (ROSCAs), peer-to-peer finance groups ubiquitous across the developing world. We find high rates of contribution and ROSCA success. The unexpected success of such e-ROSCAs and their potential to extend banking to the bankless poor necessitate furt
Inhibition of the NLRP3 inflammasome prevents ovarian aging
6dInflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovari
Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized 129Xe MRI
6dThe recovery process of COVID-19 patients is unclear. Some recovered patients complain of continued shortness of breath. Vasculopathy has been reported in COVID-19, stressing the importance of probing pulmonary microstructure and function at the alveolar-capillary interface. While computed tomography (CT) detects structural abnormalities, little is known about the impact of disease on lung functi
Full-field fluorescence lifetime dual-comb microscopy using spectral mapping and frequency multiplexing of dual-comb optical beats
6dFluorescence lifetime imaging microscopy (FLIM) is a powerful tool for quantitative fluorescence imaging because fluorescence lifetime is independent of concentration of fluorescent molecules or excitation/detection efficiency and is robust to photobleaching. However, since most FLIMs are based on point-to-point measurements, mechanical scanning of a focal spot is needed for forming an image, whi
Zero-trade-off multiparameter quantum estimation via simultaneously saturating multiple Heisenberg uncertainty relations
6dQuantum estimation of a single parameter has been studied extensively. Practical applications, however, typically involve multiple parameters, for which the ultimate precision is much less understood. Here, by relating the precision limit directly to the Heisenberg uncertainty relation, we show that to achieve the highest precisions for multiple parameters at the same time requires the saturation
Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice
6dLight-inducible gene switches represent a key strategy for the precise manipulation of cellular events in fundamental and applied research. However, the performance of widely used gene switches is limited due to low tissue penetrance and possible phototoxicity of the light stimulus. To overcome these limitations, we engineer optogenetic synthetic transcription factors to undergo liquid-liquid pha
Exploring microstructures in lower mantle mineral assemblages with synchrotron x-rays
6dUnderstanding dynamics across phase transformations and the spatial distribution of minerals in the lower mantle is crucial for a comprehensive model of the evolution of the Earth's interior. Using the multigrain crystallography technique (MGC) with synchrotron x-rays at pressures of 30 GPa in a laser-heated diamond anvil cell to study the formation of bridgmanite [(Mg,Fe)SiO 3 ] and ferropericla
Heteromultivalent topology-matched nanostructures as potent and broad-spectrum influenza A virus inhibitors
6dHere, we report the topology-matched design of heteromultivalent nanostructures as potent and broad-spectrum virus entry inhibitors based on the host cell membrane. Initially, we investigate the virus binding dynamics to validate the better binding performance of the heteromultivalent moieties as compared to homomultivalent ones. The heteromultivalent binding moieties are transferred to nanostruc
Low-temperature gas-phase formation of indene in the interstellar medium
6dPolycyclic aromatic hydrocarbons (PAHs) are fundamental molecular building blocks of fullerenes and carbonaceous nanostructures in the interstellar medium and in combustion systems. However, an understanding of the formation of aromatic molecules carrying five-membered rings—the essential building block of nonplanar PAHs—is still in its infancy. Exploiting crossed molecular beam experiments augme
Metabolomic shifts associated with heat stress in coral holobionts
6dUnderstanding the response of the coral holobiont to environmental change is crucial to inform conservation efforts. The most pressing problem is "coral bleaching," usually precipitated by prolonged thermal stress. We used untargeted, polar metabolite profiling to investigate the physiological response of the coral species Montipora capitata and Pocillopora acuta to heat stress. Our goal was to i
Soft implantable drug delivery device integrated wirelessly with wearable devices to treat fatal seizures
6dPersonalized biomedical devices have enormous potential to solve clinical challenges in urgent medical situations. Despite this potential, a device for in situ treatment of fatal seizures using pharmaceutical methods has not been developed yet. Here, we present a novel treatment system for neurological medical emergencies, such as status epilepticus, a fatal epileptic condition that requires imme
An auxin-regulable oscillatory circuit drives the root clock in Arabidopsis
6dIn Arabidopsis , the root clock regulates the spacing of lateral organs along the primary root through oscillating gene expression. The core molecular mechanism that drives the root clock periodicity and how it is modified by exogenous cues such as auxin and gravity remain unknown. We identified the key elements of the oscillator (AUXIN RESPONSE FACTOR 7, its auxin-sensitive inhibitor IAA18/POTEN
Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening
6dThe COVID-19 pandemic has created a public health crisis. Because SARS-CoV-2 can spread from individuals with presymptomatic, symptomatic, and asymptomatic infections, the reopening of societies and the control of virus spread will be facilitated by robust population screening, for which virus testing will often be central. After infection, individuals undergo a period of incubation during which
Visual number sense in untrained deep neural networks
6dNumber sense, the ability to estimate numerosity, is observed in naïve animals, but how this cognitive function emerges in the brain remains unclear. Here, using an artificial deep neural network that models the ventral visual stream of the brain, we show that number-selective neurons can arise spontaneously, even in the complete absence of learning. We also show that the responses of these neur
Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle
6dUnbalanced energy partitioning participates in the rise of obesity, a major public health concern in many countries. Increasing basal energy expenditure has been proposed as a strategy to fight obesity yet raises efficiency and safety concerns. Here, we show that mice deficient for a muscle-specific enzyme of very-long-chain fatty acid synthesis display increased basal energy expenditure and prot
BBB pathophysiology-independent delivery of siRNA in traumatic brain injury
6dSmall interfering RNA (siRNA)–based therapeutics can mitigate the long-term sequelae of traumatic brain injury (TBI) but suffer from poor permeability across the blood-brain barrier (BBB). One approach to overcoming this challenge involves treatment administration while BBB is transiently breached after injury. However, it offers a limited window for therapeutic intervention and is applicable to
Internal state configures olfactory behavior and early sensory processing in Drosophila larvae
6dAnimals exhibit different behavioral responses to the same sensory cue depending on their internal state at a given moment. How and where in the brain are sensory inputs combined with state information to select an appropriate behavior? Here, we investigate how food deprivation affects olfactory behavior in Drosophila larvae. We find that certain odors repel well-fed animals but attract food-depr
Antimony thin films demonstrate programmable optical nonlinearity
6dThe use of metals of nanometer dimensions to enhance and manipulate light-matter interactions for emerging plasmonics-enabled nanophotonic and optoelectronic applications is an interesting yet not highly explored area of research beyond plasmonics. Even more importantly, the concept of an active metal that can undergo an optical nonvolatile transition has not been explored. Here, we demonstrate t
Capsid opening enables genome release of iflaviruses
6dThe family Iflaviridae includes economically important viruses of the western honeybee such as deformed wing virus, slow bee paralysis virus, and sacbrood virus. Iflaviruses have nonenveloped virions and capsids organized with icosahedral symmetry. The genome release of iflaviruses can be induced in vitro by exposure to acidic pH, implying that they enter cells by endocytosis. Genome release inte
Ultradeep sequencing differentiates patterns of skin clonal mutations associated with sun-exposure status and skin cancer burden
6dIn ultraviolet (UV) radiation–exposed skin, mutations fuel clonal cell growth. The relationship between UV exposure and the accumulation of clonal mutations (CMs) and the correlation between CMs and skin cancer risk are largely unexplored. We characterized 450 individual-matched sun-exposed (SE) and non-SE (NE) normal human skin samples. The number and relative contribution of CMs were significan
Antigen receptor repertoires of one of the smallest known vertebrates
6dThe rules underlying the structure of antigen receptor repertoires are not yet fully defined, despite their enormous importance for the understanding of adaptive immunity. With current technology, the large antigen receptor repertoires of mice and humans cannot be comprehensively studied. To circumvent the problems associated with incomplete sampling, we have studied the immunogenetic features of
Horizontal genome transfer by cell-to-cell travel of whole organelles
6dRecent work has revealed that both plants and animals transfer genomes between cells. In plants, horizontal transfer of entire plastid, mitochondrial, or nuclear genomes between species generates new combinations of nuclear and organellar genomes, or produces novel species that are allopolyploid. The mechanisms of genome transfer between cells are unknown. Here, we used grafting to identify the m
An unprecedented insight into the catalytic mechanism of copper nitrite reductase from atomic-resolution and damage-free structures
6dCopper-containing nitrite reductases (CuNiRs), encoded by nirK gene, are found in all kingdoms of life with only 5% of CuNiR denitrifiers having two or more copies of nirK . Recently, we have identified two copies of nirK genes in several α-proteobacteria of the order Rhizobiales including Bradyrhizobium sp. ORS 375, encoding a four-domain heme-CuNiR and the usual two-domain CuNiR ( Br 2D NiR). C
Airflows inside passenger cars and implications for airborne disease transmission
6dTransmission of highly infectious respiratory diseases, including SARS-CoV-2, is facilitated by the transport of exhaled droplets and aerosols that can remain suspended in air for extended periods of time. A passenger car cabin represents one such situation with an elevated risk of pathogen transmission. Here, we present results from numerical simulations to assess how the in-cabin microclimate o
Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimers brains is mediated by USP25
6dDown syndrome (DS), caused by trisomy of chromosome 21, is the most significant risk factor for early-onset Alzheimer's disease (AD); however, underlying mechanisms linking DS and AD remain unclear. Here, we show that triplication of homologous chromosome 21 genes aggravates neuroinflammation in combined murine DS-AD models. Overexpression of USP25 , a deubiquitinating enzyme encoded by chromosom
Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice
6dNephrotic syndrome (NS) is a leading cause of chronic kidney disease. We found recessive NOS1AP variants in two families with early-onset NS by exome sequencing. Overexpression of wild-type (WT) NOS1AP , but not cDNA constructs bearing patient variants, increased active CDC42 and promoted filopodia and podosome formation. Pharmacologic inhibition of CDC42 or its effectors, formin proteins, reduce
A general approach to composites containing nonmetallic fillers and liquid gallium
6dWe report a versatile method to make liquid metal composites by vigorously mixing gallium (Ga) with non-metallic particles of graphene oxide (G-O), graphite, diamond, and silicon carbide that display either paste or putty-like behavior depending on the volume fraction. Unlike Ga, the putty-like mixtures can be kneaded and rolled on any surface without leaving residue. By changing temperature, the
Nanoscale chromatin imaging and analysis platform bridges 4D chromatin organization with molecular function
6dExtending across multiple length scales, dynamic chromatin structure is linked to transcription through the regulation of genome organization. However, no individual technique can fully elucidate this structure and its relation to molecular function at all length and time scales at both a single-cell level and a population level. Here, we present a multitechnique nanoscale chromatin imaging and a
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality
6dUsing AI, we identified baricitinib as having antiviral and anticytokine efficacy. We now show a 71% (95% CI 0.15 to 0.58) mortality benefit in 83 patients with moderate-severe SARS-CoV-2 pneumonia with few drug-induced adverse events, including a large elderly cohort (median age, 81 years). An additional 48 cases with mild-moderate pneumonia recovered uneventfully. Using organotypic 3D cultures
S100A8/S100A9 cytokine acts as a transcriptional coactivator during breast cellular transformation
6dCytokines are extracellular proteins that convey messages between cells by interacting with cognate receptors at the cell surface and triggering signaling pathways that alter gene expression and other phenotypes in an autocrine or paracrine manner. Here, we show that the calcium-dependent cytokines S100A8 and S100A9 are recruited to numerous promoters and enhancers in a model of breast cellular t
Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM
6dThe recent outbreaks of SARS-CoV-2 pose a global health emergency. The SARS-CoV-2 trimeric spike (S) glycoprotein interacts with the human ACE2 receptor to mediate viral entry into host cells. We report the cryo-EM structures of a tightly closed SARS-CoV-2 S trimer with packed fusion peptide and an ACE2-bound S trimer at 2.7- and 3.8-Å resolution, respectively. Accompanying ACE2 binding to the up
Geospatial distributions reflect temperatures of linguistic features
6dQuantifying the speed of linguistic change is challenging because the historical evolution of languages is sparsely documented. Consequently, traditional methods rely on phylogenetic reconstruction. Here, we propose a model-based approach to the problem through the analysis of language change as a stochastic process combining vertical descent, spatial interactions, and mutations in both dimension
Ediacaran metazoan reveals lophotrochozoan affinity and deepens root of Cambrian Explosion
6dThrough exceptional preservation, we establish a phylogenetic connection between Ediacaran and Cambrian metazoans. We describe the first three-dimensional, pyritized soft tissue in Namacalathus from the Ediacaran Nama Group, Namibia, which follows the underlying form of a stalked, cup-shaped, calcitic skeleton, with six radially arranged lobes projecting into an apical opening and lateral lumens.
Scientific integrity at Science Advances: Essential pillar supporting scientific progress
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Space: 2021
6dWhatever craziness may be happening on Earth, the coming year promises to be a spectacular one across the solar system.
Golden ticket: the lucky tourists sitting out coronavirus in New Zealand
6dVisitors from UK and North America tell of finding themselves with a pass to one of the best-rated pandemic responses in the world For Christmas 2019 Efrain Vega de Varona gave his partner plane tickets to New Zealand – her dream holiday destination. It has proved a gift that keeps on giving. A year later they are still in New Zealand, having decided to stay put at the end of their two-week holid
Ministers urged to strip away red tape to hit UK vaccine rollout target
6dDoctors say 24/7 vaccine centres and recruiting retired health workers could help reach goal Coronavirus – latest updates See all our coronavirus coverage Red tape should be stripped away to allow retired health workers help the coronavirus vaccine effort and vaccination centres should open around the clock to meet the target of immunising 30 million people by the summer, ministers have been told
Why 2020 was the year of miniatures
6dCrafting DIY miniature worlds like this one offer an escape and a sense of control. (Ruocaled/) Between a poorly-managed pandemic, the worst wildfire season on record, and a heated election cycle, 2020 was more chaotic than any year in recent memory. In the midst of this swirling vortex, some Americans took shelter in the peaceful world of miniatures. TikTok users created half-pint haunted houses
Experts question UK decision on Covid vaccine dosing regimen
6dHealth authorities argue that broader, if slightly lower, immunity for more people is needed
Spørg Fagfolket: Hvorfor bliver agurkeskiver hårde i vand?
6dEn læser undrer sig over en mærkelig effekt, som vand tilsyneladende har på agurkeskiver. De bliver nærmest hårde. Forskere fra KU Food forklarer hvorfor.
Forced Responses: Jan 2021
6dA new open thread for climate solutions in the new year (and the soon-to-be new US administration actions). As for the climate science open threads, please try to renew your commitment to constructive dialog that prioritises light over heat (like LED bulbs for instance!). Thanks!
Unforced Variations: Jan 2021
6dAccording to the somewhat * arbitrary customs of our age, the 1st of January marks the beginning of a new year, a new decade and, by analogy, a new start in human affairs. So shall it be at RealClimate too ** . This month's topics will no doubt include the summaries of the 2020 climate (due Jan 14th or so), ongoing efforts to understand and predict extreme weather in a climate context, and the sh
Zoom Book Tours: 5 Authors on Publishing in a Pandemic
7dWIRED asked the writers of five of our favorite 2020 titles what it was like to release a book during Covid-19.
Goodbye virus-ridden 2020, hello Roaring Twenties
7dThere are good reasons to believe that a decade of strong growth and social ebullience lies ahead
How to Talk Like a Physicist – Facts So Romantic
7dTheoretical physicist Sabine Hossenfelder, who probably is the smartest person on her block, has fun in her latest video skewering the scientific braggart. Photograph by Francisco De Legarreta C. / Unsplash The other night I was out on our street with the neighbors for a socially distanced hang. My two-year-old daughter, mistaking the only street light on the road for the moon, pointed at it sayi
Dansk teknologi kortlægger grundvand i Sydafrika som en flyvende pilekvist
7dPLUS. For to år siden stod Cape Town i Sydafrika til at blive den første millionby i verden, der løb tør for vand. Kommunen Saldanha Bay var kun to dage fra katastrofen og har nu sat sin lid til en dansk opfindelse for at sikre sine forsyninger.
How to make the most of meditation with science
7dTake a deep breath and give meditation a try. (Deposit Photo/) 2020 definitely threw a lot of us off of our groove, so there's never been a better time to look for moments of zen. After all, studies show mindfulness and meditation can reduce blood pressure, symptoms of anxiety and depression, and stress overall. But with more than 1,300 meditation apps available for download (not to mention count
Exploring Space Can Unite the U.S.–but Not in the Way You Might Think
7dSurvey show that Americans want NASA to monitor climate change and asteroid threats, not land astronauts on the moon — Read more on ScientificAmerican.com
The Dark Reality of Betting Against QAnon
7dQ Anon—the conspiracy theory that elite Democrats, government officials, and celebrities are part of a cannibalistic, child-sex-trafficking cult, and Donald Trump is the hero destined to stop them —has allegedly inspired kidnappings, car chases, and a murder . It has also made 28-year-old Patrick Cage a lot of money. In 2018, Cage, a Californian who works in international environmental policy, di
How to Make the Most of a Virtual Therapy Session
7dAnd some Instagram resources to shore up your mental health, if therapy isn't an option right now.
How to Cook in Your Tiny Kitchen (and Stay Sane)
7dYour cooking area is the size of a Game Boy. But with some strategic gear you can still whip up a storm of good food.
Why The COVID-19 Vaccine Distribution Has Gotten Off To A Slow Start
7dThe rollout of vaccines for COVID-19 has been slower than expected. Reasons include local logistics, lack of funding and staffing struggles during the winter holidays.
Ethics Lesson May Hold outside the Classroom
7dOne college class discussion had weeks-long effects on meat consumption — Read more on ScientificAmerican.com
Ethics Lesson May Hold outside the Classroom
7dOne college class discussion had weeks-long effects on meat consumption — Read more on ScientificAmerican.com
Tre tendenser, der kan få det smarte hjem på sporet
7dPLUS. Udviklingen inden for smart homes giver håb for dem, der venter på enklere løsninger, der kan trække deres hjem i en grønnere retning.
Is America Still the 'Shining City on a Hill'?
7dA shining city on a hill. Ronald Reagan loved the phrase. He used it over and over again, perhaps most notably in his 1989 presidential farewell address . I've spoken of the shining city all my political life, but I don't know if I ever quite communicated what I saw when I said it. But in my mind it was a tall, proud city built on rocks stronger than oceans, wind-swept, God-blessed, and teeming w
There's Mounting Evidence That Life on Earth Started With More Than Just RNA
7dHow did the first lifeforms replicate?
Risky Business: The Future of Cyborg Babies — BPN Today News
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Desalination Breakthrough Could Lead to Cheaper Fresh Water
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This is how Earth could be entirely powered by sustainable energy
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Health as a foundation for society "The case for universal health coverage has never been clearer"
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5 Undeniable Long-Term Trends Shaping Society's Future "Aging World, Urban Evolution, Rising Middle Class. Rising Wealth inequality and Environmental Pressures"
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Primordial black holes and the search for dark matter from the multiverse
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Geothermal discovery could launch green revolution for energy industry
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UK scientists have been awarded funding to develop a robust, low-cost ventilator to help patients in low and middle-income countries suffering from severe respiratory problems due to Covid-19.
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DRDO's new quantum device can generate random numbers using light particles
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The Most Innovative Companies of 2020 [Megathread]
7dDespite all the tragedy that has happened this year, a lot of disruptive innovation has been happening all over the world, from cutting-edge robotics and AI, all the way to fintech. My day job consists of finding and analyzing high-growth-potential industry disruptors for my intelligence co. That said, I wanted to share with you some of the most innovative companies of 2020. Most Innovative Compa
The future of complete and total immersion VR is closer than you think
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Scientists print wearable biometric sensors directly on the skin without heat
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Engineers use AI to convert ancient-times maps into a satellite-like images
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Trains powered by human waste , animal manure and food leftovers could replace small trams and help run small branch lines.
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Forget Your Five-Year Plan: What If We Visualized Humanity's Future in Centuries, Millennia, and Beyond?
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5 Undeniable Long-Term Trends Shaping Society's Future
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2021 could be a huge year for space. Here's what's to come from NASA, Elon Musk, Richard Branson and Jeff Bezos. From a rover landing on Mars to more human spaceflight missions, big projects are in the works
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Elon Musk congratulated Ford on its all-electric Mustang Mach-E SUV, a threat to Tesla, saying the move would "encourage other carmakers to go electric too."
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Four-day week is affordable for most firms, reports new study
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Why Chimpanzees Don't Hold Elections: The Power of Social Reality
7dBy deploying the brain's ability to compress information and think abstractly, humans are the only animals on the planet who can simply make things up, agree on them as a group, and they become real. This "social reality" is a superpower that gives us far more control over reality than we might think.
Meteor Showers in 2021 That Will Light Up Night Skies
7dAll year long, Earth passes through streams of cosmic debris. Here's a list of some major meteor showers and how to spot them.
The Problem With Problem Sharks
7dA marine biologist's ideas for singling out sharks that attack humans have prompted objections from other shark scientists.
How Trump Tried, but Largely Failed, to Derail America's Top Climate Report
7dThe White House repeatedly attempted to thwart the country's premier climate science document, one meant to steer policy for years. Scientists got in the way.
Habits: How to be successful every day
7dHabits, both good and bad, are pre-made decisions that makeup around 40 percent of our day and require no real conscious thought. In order to regain control, resist environmental temptations, and reduce your bad habits, it helps to understand the three parts of a habit loop: the cue (or trigger), the behavior itself, and the reward. Gretchen Rubin, Dan Ariely, Charles Duhigg, Adam Alter, and othe
New Coronavirus Variant Now in US And UK Doesn't Cause More Severe Illness, Says Study
7dOr a higher death rate.
The Covid turning point: when did the pandemic become unstoppable?
7dScientists describe the moment they realised this was 'the big one', and the chances that were missed Coronavirus – latest updates See all our coronavirus coverage Pandemics, it has been said, are lived forwards but only understood backwards. At the end of a year in which Covid-19 has claimed 1.7 million lives since it was first identified in the Chinese city of Wuhan last December, experts are n
The pandemic taught us how not to deal with climate change
7dThere's a case to be made that 2020, for all the sacrifices it demanded and tragedies it inflicted, could at least mark a turning point on climate change. It's now possible that global oil demand and greenhouse-gas emissions may have already peaked in 2019, since the pandemic could slow economic growth for years, accelerate the demise of coal, and bring about long-lasting declines in energy deman
Dansk vaccineforsker om starten på epidemien: »Vi kom pludselig ud af vores comfort zone«
7dPLUS. Professor Ali Salanti bedrev kræftforskning i Mærsktårnet på Københavns Universitet. Men så udbrød der en pandemi.
Coronavirus live news: new Covid variant may have been in US since October
7dLatest updates: re-analysis of millions of Covid tests in US raises fresh questions about origin of B117 'UK strain' Key London hospital preparing for Covid-only care as cases surge New coronavirus variant may have been in US since October UK doctors despair over public's disregard for rules See all our coronavirus coverage 9.29am GMT 9.22am GMT Russia on Friday reported 27,039 new coronavirus ca
Giving people false hope about the pandemic isn't 'balanced' – it's dangerous | Owen Jones
7dThe media should not promote disinformation under the guise of debate Coronavirus – latest updates See all our coronavirus coverage Professor Karol Sikora, an oncologist at the private Buckingham University, has become a social media star and a regular on TV screens, thanks to his viral tweets. You can see why the "Positive Professor" has developed such a wide fanbase: in an era of death, disease
Clinical criteria for diagnosing autism inadequate for people with genetic conditions
7dPeople with certain genetic conditions are likely to have significant symptoms of autism, even if they do not meet all diagnostic criteria, a study concludes.
A new mandate highlights costs, benefits of making all scientific articles free to read
7dAs funders' Plan S requirements begin, the open-access movement shows progress and faces questions
What we have learnt about the limits of science
7dAs the battles against cancer and Covid-19 make clear, breakthroughs depend on basic research and good policies
Vägen till vaccin – ett år med corona
7dDet började med att allt fler sökte vård för en ovanlig typ av lunginflammation i trakterna runt Wuhan i Kina i december 2019. Och för exakt ett år sedan, den första januari 2020, stängde kinesiska myndigheter ner en djurmarknad i Wuhan. Spela videon och följ coronaåret 2020.
A Dog's View of Optical Illusions
7dResearchers are using visual tricks to try to better understand canine perception.
New Screening Approach Reveals Novel Regulators of Microcephaly
7dResearchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.
Infographic: Light Triggers Photocage Opening, Apoptosis Inhibition
7dResearchers develop a caspase inhibitor that only works after being irradiated with UV light, giving them control over apoptosis in human cells.
Tardigrades' List of Superpowers Grows Ever Longer
7dWater bears can survive extreme temperatures, oxidative stress, UV radiation, and more, but as work in climate change biology shows, they're not invulnerable to everything.
Honeybee Microbes Shape the Colony's Social Behavior
7dRecent research shows that the insect's microbial community is central to protecting the hive from invaders—both big and small.
Introducing Inoculation, 1721
7dAs a deadly smallpox outbreak ravaged Boston, one of the city's leaders advocated for a preventive measure he'd learned about from Onesimus, an enslaved man.
Human Fetuses Can Contract SARS-CoV-2, but It's Rare
7dCompared with Zika and cytomegalovirus, the virus that causes COVID-19 appears to have a harder time penetrating the placenta and moving to a woman's unborn baby.
An End in Sight
7dLast year humanity confronted our biggest challenge in a century. Science helped us see the light at the end of the tunnel. But we need to keep moving forward to emerge.
Light-Activated Molecules Stop Apoptosis at the Flip of a Switch
7dA new inhibitor gives researchers the ability to control programmed cell death in cultured human T cells.
How RNAs Called SINEUPs Upregulate Translation
7dThe recently discovered long noncoding RNAs seem to boost the production of specific proteins in the cell by interacting with RNA-binding proteins, researchers find.
Steps to End "Colonial Science" Slowly Take Shape
7dScientists from countries with fewer resources are pushing collaborators from higher-income countries to shed biases and behaviors that perpetuate social stratification in the research community.
Infographic: How SARS-CoV-2 Might Travel from Mom to Fetus
7dThe virus rarely spreads from mother to child before birth, but it can–and researchers are starting to investigate the path it takes.
Celine Frere Chases Dragons and Koalas to Learn How They Adapt?
7dThe biologist at the University of Sunshine Coast in Australia wants to understand why some animal species adapt well to urbanization, while others fall flat.
Opinion: Blowing the Whistle on Research Grant Fraud
7dReporting cases of misconduct in the context of federal science funding can be a daunting task. But mechanisms to support whistleblowers do exist.
A Geneticist's Quest to Understand His Son's Mysterious Disease
7dRonald Davis of Stanford University changed his focus to research on ME/CFS, the disease formerly known as chronic fatigue syndrome, in a bid to help his son and others like him.
Infographic: What Do Dogs Perceive?
7dResearchers use optical illusions to investigate canine perception.
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