International experts say 'unethical experiment' could allow vaccine-resistant variants to develop Coronavirus – latest updates See all our coronavirus coverage Boris Johnson's plan to lift virtually all of England's pandemic restrictions on Monday is a threat to the world and provides fertile ground for the emergence of vaccine-resistant variants, international experts say. Britain's position as
The summer wasn't meant to be like this. By April, Greene County, in southwestern Missouri, seemed to be past the worst of the pandemic . Intensive-care units that once overflowed had emptied. Vaccinations were rising. Health-care workers who had been fighting the coronavirus for months felt relieved—perhaps even hopeful. Then, in late May, cases started ticking up again. By July, the surge was s
A newly discovered visitor to the outer edges of our solar system has been shown to be the largest known comet ever, thanks to the rapid response telescopes of Las Cumbres Observatory. The object, which is named Comet C/2014 UN271 Bernardinelli-Bernstein after its two discoverers, was first announced on Saturday, June 19th, 2021. C/2014 UN271 was found by reprocessing four years of data from the D
Anonymous person will be replaced by 18-year-old recent high school graduate on New Shepard spacecraft The anonymous winner of a ticket to join billionaire Jeff Bezos in space next week will no longer board the New Shepard spacecraft due to "scheduling conflicts", Bezos's Blue Origin company announced on Thursday. The winner, who paid $29.7m to join one of the world's richest men in space, will i
Delta variant spreading rapidly, with one in 95 people in England testing positive for the virus last week Coronavirus – latest updates See all our coronavirus coverage More than 50,000 daily cases of coronavirus have been reported in the UK for the first time since January, with an estimated one in 95 people testing positive for the virus in England last week. The daily tally of cases has reache
'Vaccines aren't perfect,' epidemiologist says, but offer lower risk of hospitalisation and prevention against spread of virus Follow our Australia Covid live blog for the latest updates Vic hotspots ; Vic restrictions ; NSW hotspots ; NSW restrictions Vaccine rollout tracker ; get our free news app ; get our morning email Epidemiologists warn of more breakthrough Covid infections as the number o
Laurel Eich, a 42-year-old woman from Nevada, was arrested on Wednesday for burglary at a Sun Valley dental clinic where she used to work, according to a statement by the local Washoe County Sheriff's Office . In a bewildering twist, Eich also apparently admitted to extracting 13 teeth from an unwilling and anesthetized patient on an earlier date. The wildest part of the story? We have no idea wh
Lease on Life After a month-long saga, NASA says that the iconic Hubble Space Telescope is back online. "Hubble is back!" said Tom Brown, the head of the Hubble Space Telescope at the Space Telescope Science Institute, said this morning in an email obtained by Science . Soap Hubble The 31-year-old space telescope went dark in mid-June after its computer control system went down. Initial attempts
Damage Control Popular sandwich chain Subway is in full damage control mode after one test in a New York Times investigation last month found no trace of tuna DNA in the company's tuna. Now, after a strange delay, Subway's PR team is waging a publicity war to convince the public that its tuna is in fact tuna. The company even created a website, subwaytunafacts.com , to enlighten its customer base
Scheduling Conflicts Oliver Daemon, an 18-year-old from the Netherlands, will be joining Amazon founder Jeff Bezos on a journey of a lifetime next week: a trip to an altitude of 62 miles on board the Bezos-led Blue Origin's New Shepard rocket. The original ticketholder, who shelled out $28 million for the ticket and has asked to remain anonymous, isn't tagging along. Why? Because of "scheduling c
Understanding seasonality can help us to work out when the pandemic is likely to be over There is a paradox at the heart of Sars-Cov-2 transmission that has yet to be fully explored. While it's firmly established that the virus transmits best in winter, in common with most other respiratory viruses, the UK is currently experiencing a summer surge . There have also been major Covid-19 epidemic wav
What will it take? Eighty-year-old Anthony Fauci is on TikTok trying to reach the young and unvaccinated. Dating apps are steering people toward health clinics. The first lady, Jill Biden, is venturing into red America to coax the unwilling into getting shots. White House aides regularly swap messages on an email chain dubbed "Ideas" that flags inventive ways of persuading people to do their part
Don't Give a Truck Tesla enthusiasts have been waiting for years to get their hands on a Cybertruck, the company's upcoming electric pickup — and the wait may soon be over, if the Elon Musk-led company hits its targets this year . But not everybody will be that excited about the brutalist, stainless steel vehicle. In fact, it wouldn't surprise Musk if his company's latest offering kinda bombs. "T
Tests could show the probability of illnesses occurring in five, 10 or 20 years, with huge moral and ethical implications We're soon going to have to make our own choices about social distancing, wearing masks and travel. When the legal enforcement of rules is lifted, the way in which each of us deals with the risk of Covid-19 will be down to personal judgment. But how well equipped are we to mak
Mach-Eau Ford has launched a new petrol-scented fragrance called "Mach-Eau," designed to appease nostalgic owners of the upcoming Mach-E GT, a sporty variant of its first first fully electric Mustang. And, no, this isn't an extremely late "Voltswagen"-level disaster of an April Fool's joke. The "premium fragrance" is "for those who crave the performance of the new all-electric Mustang Mach-E GT y
If civilisation perishes on planet Earth, Musk, Bezos and Branson seem to think humans have a backup elsewhere Branson, Bezos, Musk: why are these billionaires, with all their worldly riches, fixated on space travel? The Tesla founder, Elon Musk, argues that in becoming "multiplanetary", humans might gain "failsafe" protection from the risks of extinction or planetary collapse, while Amazon's Jef
Roadrunner Documentary filmmaker Morgan Neville's latest documentary is about the life of the legendary author and TV personality Anthony Bourdain, who tragically died by suicide back in 2018. To fill in some of the gaps, The New Yorker reports , Neville used artificial intelligence to recreate Bourdain's voice for three different quotes in his documentary, "Roadrunner: A Film About Anthony Bourd
English Institute of Sport to roll out saliva tests tracking hormones that may drive fluctuation in women's performance Highs and lows are a feature of any athlete's career, but for some female contestants, these peaks and troughs in performance may come more regularly – driven by hormonal changes associated with their menstrual cycles. Now, the English Institute of Sport (EIS) is seeking to leve
D uring the interview, I realized almost immediately that the woman was pregnant—I guessed she was about halfway along—but she didn't remark on it, and of course neither did I. Over the phone, we'd discussed only her 3-year-old daughter. The woman, whose name was Diane, was looking for a babysitter for the girl, whose name was Sophie, two mornings a week from 9 a.m. to noon, for $10 an hour. This
Illustrations by Vanessa Saba If you want a preview of next year's Emmy Awards, just take a walk past your local bookstore. According to data drawn from Publishers Marketplace, the industry's clearinghouse for news and self-reported book deals, literary adaptations to television have been on a steady climb. The site has listed nearly 4,000 film and television deals since it launched in 2000, and
Scientists on the hunt for an unconventional kind of superconductor have produced the most compelling evidence to date that they've found one. In a pair of papers, researchers at the University of Maryland's (UMD) Quantum Materials Center (QMC) and colleagues have shown that uranium ditelluride (or UTe2 for short) displays many of the hallmarks of a topological superconductor—a material that may u
Jeff Bezos has finalized the manifest for his company's first passenger flight to space, and it's a rather unusual bunch. There's Bezos himself, the richest person in the world, who sold some of his Amazon stock to fund his space venture, Blue Origin. His brother, Mark, with whom he wanted to share the experience. Wally Funk, an 82-year-old American pilot who in the early 1960s passed the same tr
Public urged to join world's biggest butterfly count to help collect data on impacts of climate crisis Butterflies across the UK have been hit hard by unseasonably cold and wet spring weather, conservationists have warned. April was the sunniest on record but it also had a record number of frosts followed by the wettest May for England in 54 years . Native butterflies such as the small tortoisesh
Scientists cannot shield the prime minister from the fallout of an unethical policy that will see rising deaths This week Boris Johnson presented the UK with his plan to lift all of England's Covid restrictions on Monday. He was flanked by Chris Whitty, the chief medical officer, and Sir Patrick Vallance, the government's chief scientific adviser. Both men were there to show that Mr Johnson is fo
Most of the tests that doctors use to diagnose cancer—such as mammography, colonoscopy, and CT scans—are based on imaging. More recently, researchers have also developed molecular diagnostics that can detect specific cancer-associated molecules that circulate in bodily fluids like blood or urine.
In the first episode of HBO's new miniseries The White Lotus , Shane (played by Jake Lacy) and his new wife, Rachel (Alexandra Daddario), arrive on their honeymoon, on an unspecified Hawaiian island, with bagfuls of silk resort-wear and books by Malcolm Gladwell. Alone in their suite, Jake moves in to kiss Rachel, but he's suddenly gripped by a suspicion that all might not be entirely copacetic.
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox. Certain elections balloon beyond their candidates, embodying the central tensions of the political moment. Right now, that race is the Republican primary for an Ohio Senate seat. As they say, it's
I was part of the F1 champion's commission. As a Black female engineer, I've seen the lack of minorities in science and technology I was delighted to receive an email from Lewis Hamilton last year, asking that I join his newly created commission on diversity in British motorsport. I accepted because Hamilton has become a champion for social change through the platform sport gives him. After 10 mo
Due to the global efforts to meet sustainability standards, many countries are currently looking to replace concrete with wood in buildings. France, for example, will require that all new public buildings will be made from at least 50 percent wood or other sustainable materials starting in 2022.
Great leaps in science and technology have been propelled by recent advances in seeing fast evolving physical phenomena, as they happen. Femtosecond lasers from the infrared to the X-ray region have enabled us to 'watch', in real time, atoms dance in molecules and solids on femtosecond and picosecond timescales. Watching such fascinating motions not just in real time, but at the spatial locations
Using a D-Wave quantum-annealing computer as a testbed, scientists at Los Alamos National Laboratory have shown that it is possible to isolate so-called emergent magnetic monopoles, a class of quasiparticles, creating a new approach to developing "materials by design."
Orgies are back. Or at least that's what advertisers want you to believe. One commercial for chewing gum —whose sales tanked during 2020 because who cares what your breath smells like when you're wearing a mask—depicts the end of the pandemic as a raucous free-for-all with people embracing in the streets and making out in parks. The reality is a little different. Americans are slowly coming out o
Recently, Quanta has explored the collaboration between physics and mathematics on one of the most important ideas in science: quantum field theory. The basic objects of a quantum field theory are quantum fields, which spread across the universe and, through their fluctuations, give rise to the most fundamental phenomena in the physical world. We've emphasized the unfinished business in both… S
Alliances are shifting as states led by China and Russia compete with the US and tech entrepreneurs Liu Boming took in the dizzy view. Around him lay the inky vastness of space. Below was the Earth. "Wow," he said, laughing. "It's too beautiful out here." Over the next seven hours Liu and his colleague Tang Hongbo carried out China's second spacewalk, helped along by a giant robotic arm. Mission
A team of researchers from Stanford University and the University of Leuven in Belgium has further elucidated an intriguing process that could be an important step toward a methanol fuel economy with abundant methane as the feedstock, an advance that could fundamentally change how the world uses natural gas.
Anti-government protests in Cuba, a stranded orca in New Zealand, a spaceplane above New Mexico, destructive flooding in Europe, images from the Tour de France, power outages in Tehran, scenes from the Cannes Film Festival, and much more
A team of researchers has developed a way to significantly increase the memory of speckle patterns, the very complex patterns that result from shining a laser light onto an opaque sheet, such as paper, biological tissue, or fog.
Britain has broken the promises Boris Johnson made before the G7 – a change of tack is necessary to make Cop26 a success Covid and the climate crisis are the two defining global crises of our time and Britain has a crucial role to play in addressing them both. As the Cop26 host, it will be responsible for overseeing a successful outcome at the UN climate talks in Glasgow in November. Only a few w
Pharmaceuticals firm thinks creating cluster of companies at its site could result in up to 5,000 jobs GlaxoSmithKline is seeking to create a £400m campus in Stevenage for new life sciences companies that it believes could result in up to 5,000 jobs over the next decade. The pharmaceuticals company has kicked off a process to find a private sector developer to transform a third of its existing 37
Measurements of biomechanical properties inside living cells require minimally-invasive methods. Optical tweezers are particularly attractive as a tool. They use the momentum of light to trap and manipulate micro- or nanoscale particles. A team of researchers led by Prof. Dr. Cornelia Denz from the University of Münster (Germany) has now developed a simplified method to perform the necessary calib
Engineers have made considerable progress in checking off NASA's James Webb Space Telescope's final series of tests. Three big milestones have recently been completed, bringing the world's most complex and powerful space science telescope ever built much closer to being fully prepared for its million-mile journey to orbit. These three testing milestones are outlined below:
Nature, Published online: 16 July 2021; doi:10.1038/d41586-021-01954-4 Working with the United Nations, scientists hope to establish standards for satellite 'megaconstellations' and reduce disruption of astronomical observations.
Stream Tiger Queen on discovery+ ► https://links.discoveryplus.com/tigerqueen About Tiger Queen: The shark population in Turks and Caicos has a sizable concentration of female tiger sharks, leaving scientists wondering where all the males are hiding. Shark enthusiast Kinga Philipps joins Dr. Austin Gallagher to help solve this puzzling mystery. Subscribe to Discovery: http://bit.ly/SubscribeDisco
A team of astronomers has released new observations of nearby galaxies that resemble colourful cosmic fireworks. The images, obtained with the European Southern Observatory's Very Large Telescope (ESO's VLT), show different components of the galaxies in distinct colours, allowing astronomers to pinpoint the locations of young stars and the gas they warm up around them.
There are substantial differences among low- and middle-income countries in the association between BMI and diabetes risk. Individual countries can optimize diabetes screening by tailoring guidelines to their specific population's risk threshold for BMI, age and gender. In some parts of the world, diabetes risk is greater at lower BMI thresholds and in younger ages than reflected in currently used
The sodium-glucose co-transporter 2 inhibitor dapagliflozin reduced kidney, cardiovascular, and mortality risks in patients with advanced chronic kidney disease, similar to benefits seen in individuals with normal or moderately impaired kidney function. Rates of serious side effects were similar in patients with advanced chronic kidney disease who received dapagliflozin or placebo.
The results of a new study support the validity of a score that considers various patient-reported outcome measures and preferences for assessing health-related quality of life in individuals with kidney failure. The score is calculated from assessments of cognitive function, depression, fatigue, pain interference, physical functioning, sleep disturbance, and ability to participate in social roles
Smoke and heat from a massive wildfire in southeastern Oregon are creating giant "fire clouds" over the blaze—dangerous columns of smoke and ash that can reach up to 6 miles (10 kilometers) in the sky and are visible from more than 100 miles (160 kilometers) away.
A three-day celebration of what would have been history-making astronaut John Glenn's 100th birthday began Friday in his birthplace and childhood hometown in Ohio, even as additional events were announced to mark the occasion.
A new study has found that the antibiotic azithromycin was no more effective than a placebo in preventing symptoms of COVID-19 among non-hospitalized patients, and may increase their chance of hospitalization, despite widespread prescription of the antibiotic for the disease.
Although the risk of a child being admitted to hospital due to COVID-19 is small, a new UK study has found that around 1 in 20 of children hospitalized with COVID-19 develop brain or nerve complications linked to the viral infection.
Researchers at UC San Diego School of Medicine and Rady Children's Institute for Genomic Medicine have produced a stem cell model that demonstrates a potential route of entry of SARS-CoV-2, the virus that causes COVID-19, into the human brain.
There's nothing worse than desperately trying to charge your wireless device when you have to sift through a messy pile of wires. Instead of dealing with the mess and stress of wired charging, what if there was an attractive way to wirelessly charge your devices that blended seamlessly into your design aesthetic. That way, you could say goodbye to all the wires that hang from the sides of sofas a
Nature, Published online: 16 July 2021; doi:10.1038/d41586-021-01969-x With Allison Crimmins completing the new federal climate team, scientists say the fifth National Climate Assessment is back on solid ground.
Despite advances in deep neural networks, computers still struggle with the very human skill of 'imagination.' Now, a research team has developed an AI that uses human-like capabilities to imagine a never-before-seen object with different attributes.
Engineers made a pneumatic RAM chip using microfluidic valves instead of electronic transistors. The valves remain sealed against a pressure differential even when disconnected from an air supply line, creating trapped pressure differentials that function as memories and maintain the states of a robot's actuators. Dense arrays of these valves can perform advanced operations and reduce the expensiv
Children with obstructive sleep apnea are nearly three times more likely to develop high blood pressure when they become teenagers than children who never experience sleep apnea, according to a new study. Children whose sleep apnea improves as they grow into adolescence, however, don't show an increased chance of having high blood pressure. High blood pressure is a major risk factor for heart dis
Many legacy media outlets played an unwitting role in the growth of the four most successful fake Twitter accounts the Russian Internet Research Agency created to spread disinformation during the 2016 US presidential campaign, according to a study. In roughly two years beginning in late 2015, these accounts went from obscurity to microcelebrity status, growing from about 100 to more than 100,000
The hydrothermal vent fluids from the Gorda Ridge spreading center in the northeast Pacific Ocean create a biological hub of activity in the deep sea. There, in the dark ocean, a unique food web thrives not on photosynthesis but rather on chemical energy from the venting fluids. Among the creatures having a field day feasting at the Gorda Ridge vents is a diverse assortment of microbial eukaryotes
U.S. corn and soybean varieties have become increasingly heat and drought resistant as agricultural production adapts to a changing climate. But the focus on developing crops for extreme conditions has negatively affected performance under normal weather patterns, a new study shows.
Researchers have described a novel primary immunodeficiency due to a mutation in AIOLOS. This acts through a novel pathogenic mechanism termed 'heterodimeric interference', whereby when two different proteins bind together in a heterodimer, the mutant protein hijacks the function of the normal protein. In a mouse model, they were able to restore some of the lost functions by interfering with the m
When a liquid is cooled rapidly, it gains viscosity and eventually becomes a rigid solid glass. The point at which it does so is known as the glass transition. A collaborative research group has furthered our understanding of this phenomenon through the use of high entropy metallic glasses.
The brain mechanisms underlying the suppression of fear responses have attracted a lot of attention as they are relevant for therapy of human anxiety disorders. Despite our broad understanding of the different brain regions activated during the experience of fear, how fear responses can be suppressed remains largely elusive. Researchers have now discovered that the activation of identified central
New research published in Nature Medicine reveals willingness to get a COVID-19 vaccine was considerably higher in developing countries (80% of respondents) than in the United States (65%) and Russia (30%). The study provides one of the first insights into vaccine acceptance and hesitancy in a broad selection of low- and-middle income countries (LMIC), covering over 20,000 survey respondents and b
A recently developed method by Institute for Systems Biology (ISB) and University of California, Riverside provides new insights into cancer biology by allowing researchers to show how fatty acids are absorbed by single cells.
A team of researchers has developed a simplified method to perform the necessary calibration of optical tweezers. Shortening the measurement time helps to reduce the risk of damage to biological samples due to light-induced heating.
Nutrient acquisition is crucial for oceanic microbes, and competitive solutions to solve this challenge have evolved among a range of unicellular protists. However, solitary solutions are not the only approach found in natural populations. A diverse array of oceanic protists form temporary or even long-lasting attachments to other protists and…
Cellular respiration is powered by membrane-bound redox enzymes that convert chemical energy into an electrochemical proton gradient and drive the energy metabolism. By combining large-scale classical and quantum mechanical simulations with cryo-electron microscopy data, we resolve here molecular details of conformational changes linked to proton pumping in the mammalian complex…
CD8+ T cells are inherently cross-reactive and recognize numerous peptide antigens in the context of a given major histocompatibility complex class I (MHCI) molecule via the clonotypically expressed T cell receptor (TCR). The lineally expressed coreceptor CD8 interacts coordinately with MHCI at a distinct and largely invariant site to slow…
Cell survival in response to stress is determined by the coordination of various signaling pathways. The kinase p38α is activated by many stresses, but the intensity and duration of the signal depends on the stimuli. How different p38α-activation dynamics may impact cell life/death decisions is unclear. Here, we show that…
Rhythm perception is fundamental to speech and music. Humans readily recognize a rhythmic pattern, such as that of a familiar song, independently of the tempo at which it occurs. This shows that our perception of auditory rhythms is flexible, relying on global relational patterns more than on the absolute durations…
Most high-dimensional datasets are thought to be inherently low-dimensional—that is, data points are constrained to lie on a low-dimensional manifold embedded in a high-dimensional ambient space. Here, we study the viability of two approaches from differential geometry to estimate the Riemannian curvature of these low-dimensional manifolds. The intrinsic approach relates…
The posteromedial cortex (PMC) is known to be a core node of the default mode network. Given its anatomical location and blood supply pattern, the effects of targeted disruption of this part of the brain are largely unknown. Here, we report a rare case of a patient (S19_137) with confirmed…
As collective cell migration is essential in biological processes spanning development, healing, and cancer progression, methods to externally program cell migration are of great value. However, problems can arise if the external commands compete with strong, preexisting collective behaviors in the tissue or system. We investigate this problem by applying…
Programmed cell death protein-1 (PD-1) expressed on activated T cells inhibits T cell function and proliferation to prevent an excessive immune response, and disease can result if this delicate balance is shifted in either direction. Tumor cells often take advantage of this pathway by overexpressing the PD-1 ligand PD-L1 to…
In the ocean, most hosts acquire their symbionts from the environment. Due to the immense spatial scales involved, our understanding of the biogeography of hosts and symbionts in marine systems is patchy, although this knowledge is essential for understanding fundamental aspects of symbiosis such as host–symbiont specificity and evolution. Lucinidae…
Parent-of-origin–dependent gene expression in mammals and flowering plants results from differing chromatin imprints (genomic imprinting) between maternally and paternally inherited alleles. Imprinted gene expression in the endosperm of seeds is associated with localized hypomethylation of maternally but not paternally inherited DNA, with certain small RNAs also displaying parent-of-origin–specifi
KdpFABC is an oligomeric K+ transport complex in prokaryotes that maintains ionic homeostasis under stress conditions. The complex comprises a channel-like subunit (KdpA) from the superfamily of K+ transporters and a pump-like subunit (KdpB) from the superfamily of P-type ATPases. Recent structural work has defined the architecture and generated contradictory…
Mercury is toxic to wildlife and humans, and forests are thought to be a globally important sink for gaseous elemental mercury (GEM) deposition from the atmosphere. Yet there are currently no annual GEM deposition measurements over rural forests. Here we present measurements of ecosystem–atmosphere GEM exchange using tower-based micrometeorological methods…
The cytoplasmic tails of classical cadherins form a multiprotein cadherin–catenin complex (CCC) that constitutes the major structural unit of adherens junctions (AJs). The CCC in AJs forms junctional clusters, "E clusters," driven by cis and trans interactions in the cadherin ectodomain and stabilized by α-catenin–actin interactions. Additional proteins are known…
Previous research has linked perceived social isolation (loneliness) to reduced antiviral immunity, but the immunologic effects of the objective social isolation imposed by pandemic "shelter in place" (SIP) policies is unknown. We assessed the immunologic impact of SIP by relocating 21 adult male rhesus macaques from 2,000-m2 field cage communities…
Aromatic carotenoid-derived hydrocarbon biomarkers are ubiquitous in ancient sediments and oils and are typically attributed to anoxygenic phototrophic green sulfur bacteria (GSB) and purple sulfur bacteria (PSB). These biomarkers serve as proxies for the environmental growth requirements of PSB and GSB, namely euxinic waters extending into the photic zone. Until…
Fertility rates have declined dramatically in most countries in Asia and Latin America in the last 50 y, with slower declines in sub-Saharan Africa (1, 2). For example, the total fertility rate (TFR), the number of children a woman would have over her lifetime if she experienced the age-specific fertility…
The lateral gate of the bacterial translocon SecYEG is the point of entry for proteins destined for the lipid bilayer to insert into the plasma membrane. A study in PNAS has identified local dynamics at the gate: Mercier et al. (1) masterfully apply single-molecule fluorescence techniques to the translocon reconstituted…
Scientists have invented a first-of-its-kind instrument to peer deeply into billions of Twitter posts–providing an unprecedented, minute-by-minute view of popularity, from rising political movements, to K-pop, to emerging diseases. The tool–called the Storywrangler–gathers phrases across 150 different languages, analyzing the rise and fall of ideas and stories, each day, among people around the
A team of researchers has developed a new algorithm that can serve as a more effective way to analyze models of biological systems, which in turn allows a new path to understanding the decision-making circuits that make up these systems. The researchers add that the algorithm will help scientists study how relatively simple actions lead to complex behaviors, such as cancer growth and voting patter
Using time- and spin-resolved methods at BESSY II, the physicists explored how, after optical excitation, the complex interplay in the behavior of excited electrons in the bulk and on the surface results in unusual spin dynamics. The work is an important step on the way to spintronic devices based on topological materials for ultrafast information processing.
For the first time ever, researchers from the University of Pittsburgh School of Medicine discovered that phages—tiny viruses that attack bacteria—are key to initiating rapid bacterial evolution leading to the emergence of treatment-resistant "superbugs." The findings were published today in Science Advances.
Many humans carry genes from Neanderthals, a legacy of past admixture. Existing methods detect this archaic hominin ancestry within human genomes using patterns of linkage disequilibrium or direct comparison to Neanderthal genomes. Each of these methods is limited in sensitivity and scalability. We describe a new ancestral recombination graph inference algorithm that scales to large genome-wide d
In real time, Twitter strongly imprints world events, popular culture, and the day-to-day, recording an ever-growing compendium of language change. Vitally, and absent from many standard corpora such as books and news archives, Twitter also encodes popularity and spreading through retweets. Here, we describe Storywrangler, an ongoing curation of over 100 billion tweets containing 1 trillion 1-gra
The mechanisms maintaining adult lymphatic vascular specialization throughout life and their role in coordinating inter-organ communication to sustain homeostasis remain elusive. We report that inactivation of the mechanosensitive transcription factor Foxc2 in adult lymphatic endothelium leads to a stepwise intestine-to-lung systemic failure. Foxc2 loss compromised the gut epithelial barrier, pro
Influential theories postulate distinct roles of catecholamines and acetylcholine in cognition and behavior. However, previous physiological work reported similar effects of these neuromodulators on the response properties (specifically, the gain) of individual cortical neurons. Here, we show a double dissociation between the effects of catecholamines and acetylcholine at the level of large-scale
We present new applications of parity inversion and time reversal to the emergence of complex behavior from simple dynamical rules in stochastic discrete models. Our parity-based encoding of causal relationships and time-reversal construction efficiently reveal discrete analogs of stable and unstable manifolds. We demonstrate their predictive power by studying decision-making in systems biology a
Nondestructive and noninvasive investigation techniques are highly sought-after to establish the degradation state of historical parchments, which is up to now assessed by thermal techniques that are invasive and destructive. We show that advanced nonlinear optical (NLO) microscopy enables quantitative in situ mapping of parchment degradation at the micrometer scale. We introduce two parameters t
Polycomb-group (PcG) proteins are epigenetic regulators that maintain the transcriptional repression of target genes following their initial repression by transcription factors. PcG target genes are repressed in some cells, but active in others. Therefore, a mechanism must exist by which PcG proteins distinguish between the repressed and active states and only assemble repressive chromatin enviro
Cannabis sativa has long been an important source of fiber extracted from hemp and both medicinal and recreational drugs based on cannabinoid compounds. Here, we investigated its poorly known domestication history using whole-genome resequencing of 110 accessions from worldwide origins. We show that C. sativa was first domesticated in early Neolithic times in East Asia and that all current hemp a
Niemann-Pick C1-like 1 (NPC1L1) protein plays a central role in the intestinal cholesterol absorption and is the target of a drug, ezetimibe, which inhibits NPC1L1 to reduce cholesterol absorption. Here, we present cryo–electron microscopy structures of human NPC1L1 in apo state, cholesterol-enriched state, and ezetimibe-bound state to reveal molecular details of NPC1L1-mediated cholesterol uptak
Unconventional superconductivity and, in particular, triplet superconductivity have been front and center of topological materials and quantum technology research. Here, we report our observation of triplet pairing in nonmagnetic CoSi 2 /TiSi 2 heterostructures on silicon. CoSi 2 undergoes a sharp superconducting transition at a critical temperature T c ~= 1.5 K, while TiSi 2 is a normal metal. W
Extensive exploration of a protein's sequence space for improved or new molecular functions requires in vivo evolution with large populations. But disentangling the evolution of a target protein from the rest of the proteome is challenging. Here, we designed a protein complex of a targeted artificial DNA replisome (TADR) that operates in live cells to processively replicate one strand of a plasmi
Inspired by the human brain, nonvolatile memories (NVMs)–based neuromorphic computing emerges as a promising paradigm to build power-efficient computing hardware for artificial intelligence. However, existing NVMs still suffer from physically imperfect device characteristics. In this work, a topotactic phase transition random-access memory (TPT-RAM) with a unique diffusive nonvolatile dual mode b
Interactions between bacteria, their close competitors, and viral parasites are common in infections, but understanding of these eco-evolutionary dynamics is limited. Most examples of adaptations caused by phage lysogeny are through the acquisition of new genes. However, integrated prophages can also insert into functional genes and impart a fitness benefit by disrupting their expression, a proce
Strong glass formers with a low fragility are highly sought-after because of the technological importance of vitrification. In the case of organic molecules and polymers, the lowest fragility values have been reported for single-component materials. Here, we establish that mixing of organic molecules can result in a marked reduction in fragility. Individual bay-substituted perylene derivatives di
A coronavirus epidemic broke out in the East Asia region more than 20,000 years ago, researchers report. Traces of the outbreak are evident in the genetic makeup of people from that area, they've found. The researchers analyzed the genomes of more than 2,500 modern humans from 26 worldwide populations, to better understand how humans have adapted to historical coronavirus outbreaks. The team used
As internet access becomes easier to get and even the most staid industries hire web designers, web design has become a key job skill not just for IT professionals, but office workers, leaders, and entrepreneurs. Yet even the simplest website is far more complex, and needs to be carefully designed with the end-user in mind. The Venus Design System makes it easier to engineer and launch any websit
Easter Island, whose native name is Rapa Nui, is a remote island in the Pacific Ocean about 2,300 miles west of Chile. Researchers have proposed that deforestation and climatic changes led to societal collapse on the island, prior to European contact. The results of a new study suggest that, despite these factors, the Rapa Nui people managed to adapt and sustain a stable society. In the popular i
The hydrothermal vent fluids from the Gorda Ridge spreading center in the northeast Pacific Ocean create a biological hub of activity in the deep sea. There, in the dark ocean, a unique food web thrives not on photosynthesis but rather on chemical energy from the venting fluids. Among the creatures having a field day feasting at the Gorda Ridge vents is a diverse assortment of microbial eukaryotes
Evolution is often portrayed as a tree, with new species branching off from existing lineages, never again to meet. The truth however is often much messier. In the case of adaptive radiation, in which species diversify rapidly to fill different ecological niches, it can be difficult to resolve relationships, and the phylogeny (i.e. evolutionary tree) may look more like a bush than a tree. This is
New research from the RIKEN Center for Brain Science (CBS) in Japan has identified a direct link between the SUV39h2 gene and the development of autism spectrum disorders (ASD). A human variant of the SUV39H2 gene led researchers to examine its absence in mice. Published in Molecular Psychiatry, the study found that when absent, adult mice exhibited cognitive inflexibility similar to what occurs i
The COVID-19 pandemic knocked many women off schedule for important health appointments, a new study finds, and many didn't get back on schedule even after clinics reopened. The effect may have been greatest in areas where such care is already likely falling behind. The study looks at screenings for breast cancer, cervical cancer and sexually transmitted infections (STI), as well as two types of b
U.S. corn and soybean varieties have become increasingly heat and drought resistant as agricultural production adapts to a changing climate. But the focus on developing crops for extreme conditions has negatively affected performance under normal weather patterns, a University of Illinois study shows.
At Shikine Island, Japan, kelp forests and abalone fisheries were once common, but over the last twenty years they have disappeared. Now, researchers from Japan have discovered that these temperate coastal marine ecosystems are becoming more 'simple', losing biodiversity, complexity and their esthetic values.
Many legacy media outlets played an unwitting role in the growth of the four most successful fake Twitter accounts hosted by the Russian Internet Research Agency (IRA) that were created to spread disinformation during the 2016 U.S. presidential campaign, according to a study led by a University at Buffalo communication researcher.
Recent findings, with important implications for ocean biogeochemistry and climate science, have been published by Nature Communications in a paper by Associate Professor Mark Holzer from UNSW Science's School of Mathematics & Statistics, with co-authors Tim DeVries (UCSB) and Casimir de Lavergne (LOCEAN).
An oral prodrug developed by a team of scientists led by Binghe Wang, Regents' Professor of Chemistry at Georgia State University, delivers carbon monoxide to protect against acute kidney injury, according to a new paper published in Chemical Science.
A UC San Francisco study has found that the antibiotic azithromycin was no more effective than a placebo in preventing symptoms of COVID-19 among non-hospitalized patients, and may increase their chance of hospitalization, despite widespread prescription of the antibiotic for the disease.
Sally Ng evaluates the effect of a hydroxyl radical generator in an office setting and has found that the benefits to indoor air quality of one type of purifying system can be offset by the generation of other pollutants that are harmful to health.
This study investigates how successful Russian Internet Research Agency Twitter accounts built followings that were central to their disinformation campaigns around the 2016 presidential election. Many legacy media outlets played an unwitting role, according to the findings.
"Plant more trees" is often the first idea that comes to mind when we think about how to prevent further climate change or at least adapt to its impacts. There are good reasons for this. Multiple studies have shown that as well as trees being a fantastic way to store carbon dioxide, they offer other benefits, such as a cooling effect in cities , the ability to reduce flood risk and boost biodiver
Satellite observations of XCO2 show greater biases apparently over oceans than over the land surface. However, no effective ways to evaluate space-time XCO2 variations over wide geographical areas exist. Observations on commercial ship tracks and aircraft routes, together with atmospehric model calculations, provide a new reference XCO2 dataset for the otherwise inaccesible areas of the world. Hig
Researchers have developed a microswimmer that appears to defy the laws of fluid dynamics: their model, consisting of two beads that are connected by a linear spring, is propelled by completely symmetrical oscillations.
JAMA Pediatrics has retracted a paper claiming that children's masks trap too-high concentrations of carbon dioxide a little more than two weeks after publishing it. The paper, by Harald Walach and colleagues, came under fire immediately after it was published on June 30, and quickly earned an editor's note. Walach had another paper — which … Continue reading
Researchers took 3-D printed reconstructions of fossil cephalopods to actual water tanks (including a swimming pool) to see how their shell structure may have been tied to their movement and lifestyle.
A new study published in Nature Communications suggests that gene therapy delivered into the brain may be safe and effective in treating aromatic L-amino acid decarboxylase (AADC) deficiency. AADC deficiency is a rare neurological disorder that develops in infancy and leads to near absent levels of certain brain chemicals, serotonin and dopamine, that are critical for movement, behavior, and sleep
All cancers fall into just two categories, according to new research from scientists at Sinai Health, in findings that could provide a new strategy for treating the most aggressive and untreatable forms of the disease.In new research out this month in Cancer Cell, scientists at the Lunenfeld-Tanenbaum Research Institute (LTRI) divide all cancers into two groups, based on the presence or absence of
The urine-caked nests of ancient desert pack rats are offering scientists a glimpse of the genetic makeup of insects from more than 34,000 years ago. For many years, scientists have been extracting DNA from the bones of ancient humans, humanoids, and animals to paint a picture of evolution and species movement. Despite what the movie Jurassic Park portrays—dinosaurs resurrected based on preserved
Racism morphs, spreading and hiding behind numerous half-truths and full-blown falsities about where it lives and who embodies it. In this actionable talk, political scientist Candis Watts Smith debunks three widely accepted myths about racism in the US and calls for a nuanced, more expansive definition to support this new era of anti-racist action.
A four-week training course made a substantial difference in helping special education teachers anticipate different ways students with learning disabilities might solve math problems, researchers report. The findings suggest that the training would help instructors more quickly identify and respond to a student's needs. The researchers also say their findings could help teachers in special educa
Using long wavelength near-infrared light, scientists at UC Davis developed a label-free microscopy approach that achieves a unique combination of deep, high resolution, and minimally invasive brain imaging. The technique images neurons and axonal myelination across the mouse neocortex and some sub-cortical regions, through the thinned skull. Now studies of brain disease can be conducted deep in t
Researchers at Vanderbilt University Medical Center (VUMC) and the Baylor College of Medicine in Houston, Texas, have taken a big step toward developing targeted treatments and vaccines against a family of viruses that attacks the gastrointestinal tract.
Physicists of the Technische Universität Dresden introduce the first implementation of a complementary vertical organic transistor technology, which is able to operate at low voltage, with adjustable inverter properties, and a fall and rise time demonstrated in inverter and ring-oscillator circuits of less than 10 nanoseconds, respectively. With this new technology they are just a stone's throw aw
New research led by the University of Cambridge suggests that autism can be detected at 18-30 months using the Quantitative Checklist for Autism in Toddlers (Q-CHAT), but it is not possible to identify every child at a young age who will later be diagnosed as autistic. The results are published today in The BMJ Paediatrics Open.
What The Study Did: N ational health care systems have different capacities to correctly identify people who died of COVID-19. Researchers in this study analyzed the gap between excess mortality and COVID-19 confirmed mortality in 67 countries to determine the extent to which official data on COVID-19 deaths might be considered reliable.
A new oral prodrug based on artificial sweetener ingredients delivers carbon monoxide to protect against acute kidney injury, a new study with mice shows. Although carbon monoxide (CO) gas is toxic in large doses, scientists have discovered it can have beneficial effects by reducing inflammation and protecting cells against injury. Previous studies have demonstrated the protective effects of CO a
A new study reports that aging Norwegians would like to live 91 years. Most people prefer a shorter life if they have dementia, chronic pain, or are a burden to their families. There is more to life than just making sure it doesn't end. The search for immortality is the plot to the oldest epic ever written . Allegedly, alchemists and conquistadors sought after it. Claims of ridiculously old age f
The article represents the transmission electron microscopy (TEM) and flow cytometry study of A-549 (human lung carcinoma) cellular uptake of Pr3+:LaF3 nanoparticles. The Pr3+:LaF3 nanoparticles are promising platforms for cell nano-sensors.
Researchers led by Pere Roca-Cusachs at the Institute for Bioengineering of Catalonia (IBEC) and Isaac Almendros at IDIBAPS discover how force dynamics affect cells, and living tissues. The results give an insight into the critical mechanical processes that occur in different diseases such as cancer.
An international research team led by YAO Zhonghua from the Institute of Geology and Geophysics of the Chinese Academy of Sciences (IGGCAS) has explained the cause of Jupiter's X-ray aurorae, a mystery that has puzzled scientists for 40 years.
Researchers from the University of Tsukuba find that the combined effects of ocean warming and acidification in temperate marine ecosystems are resulting in a loss of kelp habitat and a shift to a simple turf-dominated ecosystem. Such changes will lead to a loss of the ecosystem services provided by productive macroalgal forests or tropicalized coral-dominated reefs. These results highlight the ne
A system made with two inexpensive sensors is more accurate than smartwatches for tracking calories burned during activity, researchers report And the instructions for making the system yourself are available for free online. Whereas smartwatches and smartphones tend to be off by about 40 to 80% when it comes to counting calories burned during an activity, this system averages 13% error. "We buil
In the largest systematic review and meta-analysis to date on COVID-19 outcomes in individuals with psychiatric disorders, the odds of dying or being hospitalized following COVID-19 infection were determined to be twice as high in comparison to persons without mental disorders.*
Washington, DC / New Delhi, India – Researchers at CDDEP recently published 'Improving vaccination coverage and timeliness through periodic intensification of routine immunization: evidence from Mission Indradhanush' where they evaluated the performance of India's Mission Indradhanush (MI) child vaccination campaign — a periodic intensification of the routine immunization program.
A Ludwig Cancer Research study has found that inducing random chromosome instability (CIN) events in mice for as little as one week is enough to trigger harmful chromosomal patterns in cells that spur the formation of tumors.
Neuromodulation at high spatial resolution is crucial for advancing understanding of brain circuits and treatment of neurological diseases. Here, a tapered fiber optoacoustic emitter (TFOE) is developed for stimulation of single neurons and subcellular structures. The TFOE enabled integration with patch clamp recording and unveiled cell-type-specific response of excitatory and inhibitory neurons t
Solid oxide fuel cells (SOFCs) are a promising technology for cleanly converting chemical energy to electrical energy. But their efficiency depends on the rate at which solids and gasses interact at the devices' electrode surfaces. Thus, to explore ways to improve SOFC efficiency, an international team led by researchers from Berkeley Lab studied a model electrode material in a new way – by exposi
Stream MechaShark on discovery+ ► https://links.discoveryplus.com/mechashark About MechaShark: To track down New Zealand's monster great whites, researchers build a submersible designed to look like a shark and pilot it deep into what they believe could be a mating ground — the Holy Grail of shark science. Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.
RUDN University biologists discovered the way how macrophages (the cells of the "first line" immune response) respond to inflammation and identified how the immune response depends on their origin. It turned out that when exposed to an inflammatory stimulus, two opposing mechanisms are activated in macrophages simultaneously — inducing and inhibiting inflammation. These data can potentially be us
Publication in Nature Communication: Neuro-evolutionary robotics is an approach to realize collective behaviors for swarms of robots. A comparative study of the most popular neuro-evolutionary methods shows that the control software produced by most of the analyzed methods gives good results in simulation.
Joe Sanderson arrived in El Salvador as a white American traveler with ambitions of writing a novel. But during his journey, he became something else entirely: a revolutionary, fully enmeshed in the culture he'd set out to document. The journalist Héctor Tobar's The Last Great Road Bum chronicles this transformation , interrupting Sanderson's real journal entries with commentary from Tobar. The r
Here is our next installment of a new pop-up podcast miniseries that takes your ears into the deep sound of nature. Host Jacob Job, an ecologist and audiophile, brings you inches away from a… — Read more on ScientificAmerican.com
Women and people of color remain underrepresented along every step of the tenure track in every academic field in the United States. As a new MIT study shows, progress toward equitable representation for women in academia will require active, concerted, and sustained effort—and even then, change may be slow in coming.
A new study by Vanderbilt University Medical Center researchers of more the 400,000 Medicare patients taking medications for insomnia found that the risk of death is increased when either benzodiazepines or "z-drugs" are taken with opioids.
Wildfire smoke may greatly increase susceptibility to SARS-CoV-2, the virus that causes COVID-19, according to new research from the Center for Genomic Medicine at the Desert Research Institute (DRI), Washoe County Health District (WCHD), and Renown Health (Renown) in Reno, Nev.
Exactly what happened at the beginning of the universe, 14 billion years ago, is one of the greatest mysteries in physics; there's no simple way to probe it. That's because, in its early stages , the universe was filled with a dense plasma—a gas made out of charged particles including electrons and protons (particles that comprise the atomic nucleus alongside neutrons). Photons (particles of ligh
A study led by University of Wisconsin–Madison School of Veterinary Medicine Clinical Assistant Professor Erin Lashnits provides new insights into how best to diagnose Bartonella infection in dogs, a common flea-borne disease that is linked to heart infection, organ inflammation, and other ailments.
The performance and safety of lithium-ion batteries (LIB) can be attributed to complex electrode microstructures. Microstructure analysis at the National Renewable Energy Laboratory (NREL) aims to apply in-depth knowledge of the electrodes to predict battery performances and identify optimal microstructure architecture to guide LIB development.
The commercial and industrial center of Peru, Lima is located on the mostly flat terrain in the Peruvian coastal plain, within the valleys of the Chillón, Rímac and Lurín rivers. The city is bordered on the east by the foothills of the Andes Mountains and on the west by the Pacific Ocean.
It has now been more than a month since the Hubble Space Telescope reverted to safe mode following an apparent memory failure. NASA attempted all the standard fixes such as turning it off and on, but the aging observatory stubbornly refused to come back online. After investigating the issue, NASA traced the failure to a power component on the Science Instrument Command and Data Handling module. T
Something unusual happened this year in Idaho. Fire and health officials began issuing warnings about the health risks of wildfire smoke several weeks earlier than normal. With almost the entire U.S. West in drought, it was only a matter of time before the risks became reality.
As the COVID-19 pandemic raged, news reports show that sales of electronic air cleaners have surged due to concerns about airborne disease transmission. But a research team at the Georgia Institute of Technology has found that the benefits to indoor air quality of one type of purifying system can be offset by the generation of other pollutants that are harmful to health.
Tsukuba University researchers develop a scheduling algorithm that helps automated biology labs optimize their samples throughout experiments while adhering to time constraints set by perishable materials. This work may help robots more effectively process cellular assays and clinical blood tests.
A new tool allows farmers to create a budget balance sheet of any nitrogen reduction plans and see the economic and environmental cost, return and margins, all customized to fields under their management.
In 2015, massive biomass burning events occurred in Equatorial Asia which released a large amount of carbon into the atmosphere, whose signals were captured by in-situ high-precision measurements onboard commercial passenger aircraft and a cargo ship. A simulation-based analysis with those observations estimated the fire-induced carbon emissions to be 273 Tg C for September – October 2015.
The results of scientific research can often bring considerable societal and economic benefits. But the path from the lab bench to a real-world application can take years, even for projects that are designed from the outset with a concrete use in mind. For instance, it took seven years for the pipetting robot developed by EPFL spin-off SEED Biosciences to reach the market, which it did in 2020. "O
To help address gaps in measurement and provide organizations with a tool to track the self-reliance of refugees and other displaced populations over time, researchers at the Brown School at Washington University in St. Louis have developed a Self-Reliance Index (SRI).
A 2,300-year old fragment of linen from the wrap of an Egyptian mummy, which is held in the University of Canterbury's Teece Museum of Classical Antiquities, has been matched with a fragment in the United States, at the Getty Institute.
Do you feel a bit sluggish after weekends? Would taking Friday or Monday off do the trick? Researchers from UK think tank Autonomy and the non-profit Association for Sustainability and Democracy (Alda) tend to agree in their joint report. They claim that 40-hour workweeks aren't necessary and even harmful to our well-being.
The looting of businesses, shopping centers and warehouses in South Africa over the past week, particularly in the KwaZulu-Natal and Gauteng provinces, has taken place at an unprecedented scale. It has affected both poor and middle-class areas. Private as well as government property has been damaged and destroyed. People have been injured and lives have been lost.
A pair of geophysicists from the University of Louisiana at Lafayette working with two independent researchers has found what they believe might be evidence of a massive tsunami created by the Chicxulub asteroid impact. In their paper published in the journal Earth and Planetary Science Letters, the group describes their study of seismic data for a site in Louisiana and what they found.
In the early days of cryptocurrencies , many experts viewed Bitcoin and Ethereum as passing fads. But today, it's pretty clear that cryptocurrencies are here to stay. And despite recent pullbacks, cryptocurrencies have still proven to be an unenviable investment over the long haul. So if you're looking to invest, the crypto trading platform eToro can provide you with all the innovative tools you'
Do you sign your pets' names to your holiday card? Have you ever sent your dog to day care? Do you shop regularly for cat or dog toys? Welcome to a new breed of American family—the multispecies family.
Indigenous inequality in Australia has long been known to the public and policy makers. Yet, successive local, state, and federal governments have failed to effectively make a noticeable change in Indigenous health and wellbeing.
Stanford scientists have found a more accurate way to measure a person's biological age based on a blood protein marker. The marker indicates a person's level of inflammation, which is the driver of many age-related conditions. A person's "iAge" more accurately predicts their health than their chronological age. According to biologist David Furman of Stanford University, "Every year, the calendar
More than 75% of women with Opioid Use Disorder report having had an unintended pregnancy, but they are less likely to use effective contraception compared to women who do not use drugs. Results from a multi-year trial found that a two-part intervention featuring co-located contraceptive services in opioid treatment programs and financial incentives could offer an effective solution.
An international research group, led by Jamey Marth, Ph.D., a professor at Sanford Burnham Prebys, has shown that the Neuraminidase 3 (Neu3) enzyme is responsible for the onset and progression of colitis — a chronic digestive disease caused by inflammation of the colon.
A new study finds forensics researchers use terms related to ancestry and race in inconsistent ways. The study's authors call for the discipline to adopt a new approach to better account for both the fluidity of populations and how historical events have shaped our skeletal characteristics. "Forensic anthropology is a science , and we need to use terms consistently," says Ann Ross, corresponding
A new study documents a drop in emergency room visits and a spike in the proportion of serious bacterial infections detected in newborns and young infants during the first year of the pandemic. Published in JAMA Network Open , the study shows that from March 2020 to March 2021, the number of visits to the Montreal Children's Hospital of the McGill University Health Centre (MCH-MUHC) emergency dep
A new study by University of Alberta biophysicists has revealed how a rare structure forms within RNA from the Zika virus that makes it resistant to our bodies' immune systems. The results provide a potential target for new drug therapies to combat the virus and others like it.
Many of the effects of national lockdowns in the wake of the COVID-19 pandemic will be enduring across society. Work published in the International Journal of Tourism Anthropology looks at one aspect of those effects and their impact on a vast and important industry, tourism.
Global warming imposes a major threat to plant growth and crop production. In many cases, plants could sense the temperature increase and adjust their morphology and development, facilitating plant cooling and warm adaptation. Hence, understanding the mechanisms of these morphological and developmental changes, collectively called thermomorphogenesis, could benefit the breeding of warm-adaptive cr
Immunotherapy has great potential in clinical cancer treatment due to systematic activation of antitumor immunity. However, low immunogenicity, or negative feedback on immunotherapy, greatly hinders the efficacy of currently used cancer immunotherapy.
About 70% of all energy produced in the world is wasted as heat. That's a pretty startling figure. This heat largely just dissipates into the environment, without doing anything useful. If we could reduce that waste to 40% then we could reduce our energy production needs by half. Imagine removing the least efficient and dirtiest half of our energy production from the system. Of course, this is ea
Five years ago, a killer whale called Lulu washed up on the shores of Scotland. She was thought to be over 20 years old, though autopsies revealed she had never had any offspring. Tissues recovered from Lulu suggested she was one of the most PCB-contaminated animals on the planet. She came from the UK's only resident killer whales, a group of eight, none of which had ever had young and are now con
While tropical forests remain threatened and their future is uncertain, the importance of understanding how well individual protected areas avoid deforestation increases. Researchers from the University of Turku and University of Helsinki, Finland, have investigated this question in a newly published study that focuses on the State of Acre in Brazilian Amazonia.
The nearest single star to the Sun hosts an exoplanet at least 3.2 times as massive as Earth — a so-called super-Earth. Data from a worldwide array of telescopes, including ESO's planet-hunting HARPS instrument, have revealed this frozen, dimly lit world. The newly discovered planet is the second-closest known exoplanet to the Earth and orbits the fastest moving star in the night sky.. This image
Nature, Published online: 15 July 2021; doi:10.1038/d41586-021-01970-4 Designer antibodies are based on those from people with very special immune systems. Plus, part of the Amazon is no longer a carbon sink, and why city heatwaves hit people unfairly.
Nature Communications, Published online: 16 July 2021; doi:10.1038/s41467-021-24536-4 Toll-like receptor 8 (TLR8) plays essential roles in the innate immune response to viral single-stranded RNA (ssRNA), so small molecule modulators of TLR8 are of interest, however adverse effects limit their use. Here, the authors report a tetrasubstituted imidazole CU-CPD107 with dichotomous behaviour, which in
Nature Communications, Published online: 16 July 2021; doi:10.1038/s41467-021-24623-6 Thermoelectric effects are limited to electrons to occur, and disappear at low temperatures due to electronic entropy quenching. Here, the authors report thermoelectric generation caused by nuclear spins down to 100 mK due to nuclear-spin excitation in a magnetically ordered material MnCO3.
Nature Communications, Published online: 16 July 2021; doi:10.1038/s41467-021-24642-3 Off-line neuro-evolution produces robot swarms whose good performance in simulation does not often transfer to the real word. With an extensive empirical study, Hasselmann et al. substantiate overfitting as the dominant cause.
Nature Communications, Published online: 16 July 2021; doi:10.1038/s41467-021-24562-2 KRAS is commonly mutated at codon 12 in several cancer types, offering a unique opportunity for the development of neoantigen-targeted immunotherapy. Here the authors present a pipeline for the prediction, identification and validation of HLA class-I restricted mutant KRAS G12 peptides, leading to the generation
Nature Communications, Published online: 16 July 2021; doi:10.1038/s41467-021-24619-2 Memory T cells are particularly reliant on fatty acid oxidation as a source of energy. Here the authors show this reliance is controlled by AMPK sensing of glucose deprivation that triggers SENP1-Sirt3 signalling, driving fatty acid oxidation and memory differentiation in T cells via deacetylation of YME1L1 to i
Nature Communications, Published online: 16 July 2021; doi:10.1038/s41467-021-24539-1 Practical electrochemical N2 reduction reaction is challenged by competing side reactions. Here a combination of DFT and mikrokinetic modelling reveals the potential-dependent competition between electrochemical ammonia production and hydrogen evolution on a single-site iron catalyst embedded in N-doped graphene
Nature Communications, Published online: 16 July 2021; doi:10.1038/s41467-021-24574-y Various GPCRs display constitutive ligand-independent activity, but it remains unclear whether ligand-dependent and -independent conformations differ. Here the authors demonstrate the recognition and blocking of G protein recruitment of either the ligand-bound active, or the constitutively active apo-conformatio
Nature Communications, Published online: 16 July 2021; doi:10.1038/s41467-021-24652-1 The Wzc–Wza complex forms part of the bacterial extracellular polysaccharides synthesis machinery, where cycling of the Wzc between phosphorylation states is crucial to both synthesis and export. Here the authors report the structure of the Wzc octamer and provide insight into its regulation through phosphorylat
A "systematic error" in a mental health database has led to the retraction of a 2017 paper on how people with psychosis process facial expressions. Joana Grave, a PhD student at the University of Aveiro, in Portugal, and her colleagues published their article, "The effects of perceptual load in processing emotional facial expression in psychotic … Continue reading
So, with the recent posts about the AI that fabricated better quantum experiments than a human, and the one that designed chips more efficiently than a human coming to mind: Fellow futurologists, what are your thoughts on Kurzweil's prediction that an AI will pass the turing test in 2029? At the current rate of progress I somehow feel like it's going to be sooner than that, which I find equally s
In "Projections: A Story of Human Emotions" and "A Sense of Self: Memory, the Brain, and Who We Are," Karl Deisseroth and Veronica O'Keane, respectively, use patient stories as conduits to talk about advancements in neuroscience, illuminating the brain's various structures and the connections between them.
PLUS. Vesttyskland og Benelux-landene er i disse dage hårdt ramt af massive vandmasser, der har kostet adskillige mennesker livet, mens flere fortsat er savnet. Ifølge klimaforsker Sebastian Mernild kan vi i fremtiden forvente mere nedbør og flere dage med regn over Danmark og Nordeuropa som følge af h…
Researchers from National University of Singapore and Stanford University published a new paper in the Journal of Marketing that investigates how rural consumers in India shift their expenditures towards branded consumption when they migrate to urban areas.
More people living along the eastern edge of an Oregon wildfire were told to evacuate late Thursday as the inferno began spreading rapidly and erratically in hot afternoon winds and threatened to merge with a nearby, smaller fire that had also exploded in size.
A new study from WCS and WWF reveals that nearly 20 percent of tropical Intact Forest Landscapes (IFLs) overlap with concessions for extractive industries such as mining, oil and gas. The total area of overlap is 376,449 square miles (975,000 square kilometers), about the size of Egypt. Mining concessions overlap most with tropical IFLs, at 11.33 percent of the total area, while oil and gas conces
Man bør ikke bruge Microsoft i tyske skoler, og man bør ikke bruge Google i hollandske skoler. Det vurderer landenes myndigheder efter en undersøgelse af tjenesterne, men der er ikke udsigt til en lignende vurdering fra det danske datatilsyn, oplyser man.
Some rare good news out of the last year or so has been that our masking up and socially distancing has helped keep the flu and other respiratory infections at bay . And whether you need to protect your health, or just don't want to get sick, the Respokare Flu-Fighter Masks can help protect yourself and others. Typically selling for $69, you can get a 30 Pack of Respokare Flu-Fighter Masks on sal
Schneider Shorts 15.07.2021: TCM robots and Russian lasers in space, Swedish whistleblowers at the EU Court of Justice, fraudsters and bullies retiring, an ivermectin setback, German stinginess, how Vitamin D prevents colon cancer, and how paper-mill narrative gets purged of Smut.
A team of researchers from Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), the University of Liège and the Helmholtz Institute Erlangen-Nürnberg for Renewable Energy have developed a microswimmer that appears to defy the laws of fluid dynamics: their model, consisting of two beads that are connected by a linear spring, is propelled by completely symmetrical oscillations. The findings have
PLUS. Selskabet bag den såkaldte NIFTY-test, der bruges til screening for kromosomsygdomme som Downs og Turner, som udbydes af private scanningsklinikker herhjemme, samarbejder direkte med den kinesiske folkehær.
Scientist demonstrated a new way of observing atoms as they move in a tiny quantum electronic switch as it operates. Along the way, they discovered a new material state that could pave the way for faster, more energy-efficient computing.
Contamination of urban lakes, rivers and surface water by human waste is creating pools of 'superbugs' in Low- and Middle-Income Countries (LMIC) – but improving access to clean water, sanitation and sewerage infrastructure could help to protect people's health, a new study reveals.
Shining a beam of light into potentially contaminated water samples may hold the key to real-time detection of hydrocarbons and pesticides in water. Researchers are testing the use of fluorescence to monitor water quality. The results, they say, show great promise.
The presence of more than five symptoms of COVID-19 in the first week of infection is significantly associated with the development of long COVID, irrespective of age or gender, according to a new review published by the Journal of the Royal Society of Medicine.
An observational study of more than 70,000 people in 302 UK hospitals finds that one in two people hospitalized with COVID-19 developed at least one complication. The new study, published in The Lancet, is the first to systematically assess a range of in-hospital complications, and their associations with age, sex and ethnicity, and their outcomes for the patients.
On a Saturday morning in May 2017, my wife, my daughters, and I piled into the car and headed to Turpan, a nearby city, to relax for the weekend. The winter cold still hadn't left Urumqi, and we were hoping a couple of days enjoying the warm spring weather in Turpan would be good for us. On long car trips, we usually passed the time with conversation. But it was hard to talk about anything beside
A "tantalizing" principle borrowed from nature turns harmful methane into useful methanol at room temperature. With their latest study, U.S. and Belgian scientists have brought this process an important step closer to realization.
Nature, Published online: 15 July 2021; doi:10.1038/d41586-021-01952-6 Researchers with children or carer roles have struggled more than others during the pandemic, amplifying existing inequalities, argue Edyta Swider-Cios and colleagues.
In this study using a simulated cohort, TVUS endometrial thickness screening missed over four times more cases of endometrial cancer among Black women versus White women owing to the greater prevalence of fibroids and non-endometrioid histology type that occurs among Black women.
The RegenMed Development Organization releases the results of a national survey of regenerative medicine biomanufacturing knowledge, skills, and abilities needed for successful employment in the regenerative medicine field.
A national study published in the Journal of Pediatrics found that Emergency Department (ED) visits by youth for self-harm were nearly 40 percent higher in rural areas compared to urban settings. Strikingly, ED visits by youth for self-inflicted firearm injuries were three times more common in rural areas.
A new national study published in Public Health Nutrition on July 15 found that Americans experiencing food insufficiency were three times as likely to lack mental health support during the COVID-19 pandemic than those not experiencing food insufficiency.
BioNyt Videnskabens Verden (www.bionyt.dk) er Danmarks ældste populærvidenskabelige tidsskrift for naturvidenskab. Det er det eneste blad af sin art i Danmark, som er helliget international forskning inden for livsvidenskaberne.
Bladet bringer aktuelle, spændende forskningsnyheder inden for biologi, medicin og andre naturvidenskabelige områder som f.eks. klimaændringer, nanoteknologi, partikelfysik, astronomi, seksualitet, biologiske våben, ecstasy, evolutionsbiologi, kloning, fedme, søvnforskning, muligheden for liv på mars, influenzaepidemier, livets opståen osv.
Artiklerne roses for at gøre vanskeligt stof forståeligt, uden at den videnskabelige holdbarhed tabes.