This article was originally published on our sister site, Freethink. "I was intrigued," says Ron Fouchier, in his rich, Dutch-accented English, "in how little things could kill large animals and humans." It's late evening in Rotterdam as darkness slowly drapes our Skype conversation. This fascination led the silver-haired virologist to venture into controversial gain-of-function mutation research
Hello world! We are EleutherAI , a research collective working on open-source AI/ML research. We are probably best known for our ongoing efforts to produce an open-source GPT-3-equivalent language model . We have already released several large language models trained on our large diverse-text dataset the Pile in the form of the GPT-Neo family and GPT-J-6B . The latter is the most powerful freely-
Stream Pushing the Line on discovery+ ► https://www.discoveryplus.com/show/pushing-the-line About Pushing the Line: A young crew of daredevils spend their days risking their lives to break records on ropes stretched 500 feet in the air. At night, camp is all about parties, hook ups and break ups. Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/
ARTIFICIAL INTELLIGENCE The Ethics of a Deepfake Anthony Bourdain Voice Helen Rosner | The New Yorker "The new documentary 'Roadrunner' uses AI-generated audio without disclosing it to viewers. How should we feel about that? …On Friday, to help me unknot the tangle of ethical and emotional questions raised by the three bits of 'Roadrunner' audio (totaling a mere forty-five seconds), I spoke to tw
PLUS. Forskere fra hele Norden samarbejder med lægemiddelvirksomheden AstraZeneca om at udvikle en open source DNA-test, som kan bane vej for, at flere kvinder med æggestokkræft modtager potentielt livreddende behandling.
Before we present this week's Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured: 'Tortured phrases', lost in translation: Sleuths find even more problems … Continue reading
Will we achieve immortality through the use of nanotechnology by 2080 ? When will we see nanobots circulating our bodies, destroying cancer cells and curing diseases ? submitted by /u/LeopardLast6367 [link] [comments]
Det danske slæbefly Polyt-5 var i luften første gang i starten af 1970'erne. Efter halvtreds år og tusindvis af flyvninger tager det hjemmebyggede ikon fra Polyteknisk Flyvegruppe på DTU ud på sin sidste tur lørdag.
Cyclic nucleotide-gated (CNG) ion channels of olfactory neurons are tetrameric membrane receptors that are composed of two A2 subunits, one A4 subunit, and one B1b subunit. Each subunit carries a cyclic nucleotide-binding domain in the carboxyl terminus, and the channels are activated by the binding of cyclic nucleotides. The mechanism…
In photosynthetic reaction centers from purple bacteria (PbRCs) from Rhodobacter sphaeroides, the secondary quinone QB accepts two electrons and two protons via electron-coupled proton transfer (PT). Here, we identify PT pathways that proceed toward the QB binding site, using a quantum mechanical/molecular mechanical approach. As the first electron is transferred…
Nature, Published online: 23 July 2021; doi:10.1038/d41586-021-02026-3 Research suggests that rivers are a bigger source of mercury in coastal waters than is the atmosphere — a finding that contradicts some global models.
How early is the course of COVID-19, mild or severe, determined? In Cell, researchers examined nasal cells sampled from patients at the time of diagnosis, looking for differences between those who developed severe disease and those who experienced a mild illness. Cells from patients who developed severe COVID-19 exhibited a more muted antiviral response. If the early stages of infection can determ
This event will feature NASA-funded GLOBE Observer, NeMO-Net, and Soundscapes to Landscapes citizen science projects. The GLOBE Program asks citizen scientists to submit observations of the world around them using in-app tools (clouds, mosquito habitats, land cover, and trees). Currently, photos submitted using the GLOBE Observer app of mosquito habitats and larvae will be used by NASA scientists
Mitochondrial dysfunction is found in the brain and peripheral tissues of patients diagnosed with Huntington's disease (HD), an irreversible neurodegenerative disease of which aging is a major risk factor. Mitochondrial function is encoded by not only nuclear DNA but also DNA within mitochondria (mtDNA). Expansion of mtDNA heteroplasmies (coexistence of…
The dendrites of neocortical pyramidal neurons are excitable. However, it is unknown how synaptic inputs engage nonlinear dendritic mechanisms during sensory processing in vivo, and how they in turn influence action potential output. Here, we provide a quantitative account of the relationship between synaptic inputs, nonlinear dendritic events, and action…
Tuberous sclerosis complex 1 (Tsc1) is a tumor suppressor that functions together with Tsc2 to negatively regulate the mechanistic target of rapamycin complex 1 (mTORC1) activity. Here, we show that Tsc1 has a critical role in the tight junction (TJ) formation of epithelium, independent of its role in Tsc2 and…
More than ever before, people across the world are exposed to ideas of choice and have opportunities to make choices. What are the consequences of this rapidly expanding exposure to the ideas and practice of choice? The current research investigated an unexamined and potentially powerful consequence of this salience of…
Germ cells form the basis for sexual reproduction by producing gametes. In ovaries, primordial germ cells exit the cell cycle and the pluripotency-associated state, differentiate into oogonia, and initiate meiosis. Despite the importance of germ cell differentiation for sexual reproduction, signaling pathways regulating their fate remain largely unknown. Here, we…
Foxp3-expressing CD4+CD25+ regulatory T cells (Tregs) constitutively and highly express the immune checkpoint receptor cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), whose Treg-specific deficiency causes severe systemic autoimmunity. As a key mechanism of Treg-mediated suppression, Treg-expressed CTLA-4 down-regulates the expression of CD80/CD86 costimulatory molecules on antigen-presenting
The origin of the indentation size effect has been extensively researched over the last three decades, following the establishment of nanoindentation as a broadly used small-scale mechanical testing technique that enables hardness measurements at submicrometer scales. However, a mechanistic understanding of the indentation size effect based on direct experimental observations…
Water mixing is a critical mechanism in marine habitats that governs many important processes, including nutrient transport. Physical mechanisms, such as winds or tides, are primarily responsible for mixing effects in shallow coastal systems, but the sheltered habitats adjacent to mangroves experience very low turbulence and vertical mixing. The significance…
Wireless, battery-free, and fully subdermally implantable optogenetic tools are poised to transform neurobiological research in freely moving animals. Current-generation wireless devices are sufficiently small, thin, and light for subdermal implantation, offering some advantages over tethered methods for naturalistic behavior. Yet current devices using wireless power delivery require invasive stim
Cytosolic lipopolysaccharides (LPSs) bind directly to caspase-4/5/11 through their lipid A moiety, inducing inflammatory caspase oligomerization and activation, which is identified as the noncanonical inflammasome pathway. Galectins, β-galactoside–binding proteins, bind to various gram-negative bacterial LPS, which display β-galactoside–containing polysaccharide chains. Galectins are mainly presen
Clinical research into consciousness has long focused on cortical macroscopic networks and their disruption in pathological or pharmacological consciousness perturbation. Despite demonstrating diagnostic utility in disorders of consciousness (DoC) and monitoring anesthetic depth, these cortico-centric approaches have been unable to characterize which neurochemical systems may underpin consciousnes
Cytidine triphosphate synthase (CTPS), which comprises an ammonia ligase domain and a glutamine amidotransferase domain, catalyzes the final step of de novo CTP biosynthesis. The activity of CTPS is regulated by the binding of four nucleotides and glutamine. While glutamine serves as an ammonia donor for the ATP-dependent conversion of…
Moiré superlattices in two-dimensional van der Waals heterostructures provide an efficient way to engineer electron band properties. The recent discovery of exotic quantum phases and their interplay in twisted bilayer graphene (tBLG) has made this moiré system one of the most renowned condensed matter platforms. So far studies of tBLG…
Opportunistic fungal infections have become one of the leading causes of death among immunocompromised patients, resulting in an estimated 1.5 million deaths each year worldwide. The molecular mechanisms that promote host defense against fungal infections remain elusive. Here, we find that Myosin IF (MYO1F), an unconventional myosin, promotes the expression…
Information about dangers can spread effectively by observation of others' threat responses. Yet, it is unclear if such observational threat information interacts with associative memories that are shaped by the individual's direct, firsthand experiences. Here, we show in humans and rats that the mere observation of a conspecific's threat reactions…
Fault friction is central to understanding earthquakes, yet laboratory rock mechanics experiments are restricted to, at most, meter scale. Questions thus remain as to the applicability of measured frictional properties to faulting in situ. In particular, the slip-weakening distance dc strongly influences precursory slip during earthquake nucleation, but scales with…
Long-lived quasi-stationary states (QSSs) are a signature characteristic of long-range interacting systems both in the classical and in the quantum realms. Often, they emerge after a sudden quench of the Hamiltonian internal parameters and present a macroscopic lifetime, which increases with the system size. Despite their ubiquity, the fundamental mechanism…
Individuals with depression are prone to maladaptive patterns of thinking, known as cognitive distortions, whereby they think about themselves, the world, and the future in overly negative and inaccurate ways. These distortions are associated with marked changes in an individual's mood, behavior, and language. We hypothesize that societies can undergo…
The Notch signaling system links cellular fate to that of its neighbors, driving proliferation, apoptosis, and cell differentiation in metazoans, whereas dysfunction leads to debilitating developmental disorders and cancers. Other than a five-by-five domain complex, it is unclear how the 40 extracellular domains of the Notch1 receptor collectively engage the…
Some of today's young workers, those ages 21-34, place more value on having respectful communication in the workplace over trendy work perks, a study finds. "Leaders and managers are the ones who have the power to help foster that connection of meaningful work, determine what employee well-being means, and how to communicate that meaning in a respectful way to their employees," says Danielle LaGr
In a wealth and longevity study to incorporate siblings and twin pair data, researchers analyzed the midlife net worth of adults (mean age 46.7 years) and their mortality rates 24 years later. They discovered those with greater wealth at midlife tended to live longer.
New research by an Executive PhD Research student at the Business School (formerly Cass) outlines how elderly patients with neurological conditions are significantly more likely to develop delirium shortly after they are hospitalised, and those admitted on Sunday and Tuesday are more likely to develop the disorder.
Humid tropical forests, vital in global efforts to limit rising temperatures, are under threat as a result of changes in land use and climate. Now, researchers have developed a new way to keep tabs on the vulnerability of these forests on a global scale using satellite data called the tropical forest vulnerability index (TFVI).
Did you know that the average person spends about 7 years trying to fall asleep ? If that doesn't surprise you, you may be one of the 50-to-70 million Americans who suffer from sleep problems . Luckily, one of the easiest ways to build a more effective bedtime routine is to sleep in a more comfortable position. And one of the best ways to do this is by using the Yana Sleep Body Pillow. What's The
Manipulating RNA allows plants to yield dramatically more crops and increases drought tolerance, researchers report. In initial tests, adding a gene encoding for a protein called FTO to both rice and potato plants increased their yield by 50% in field tests. The plants grew significantly larger, produced longer root systems, and were better able to tolerate drought stress. Analysis also showed th
Scientists have studied the characteristics determining the maximum running speed in animals. The model they developed explains why humans cannot keep up with the fastest sprinters in the animal kingdom. Based on these calculations, the giant spider Shelob from 'The Lord of the Rings' would have reached a maximum speed of 60 km/h.
A new optogenetic tool, a protein that can be controlled by light, has been characterized by researchers. They used an opsin — a protein that occurs in the brain and eyes — from zebrafish and introduced it into the brain of mice. Unlike other optogenetic tools, this opsin is not switched on but rather switched off by light. Experiments also showed that the tool could be suitable for investigatin
Researchers have used lignin, a natural polymer abundant in wood and other plant sources, to create a safe, low-cost and high-performing coating for use in construction. As there is a global urge to meet the rising sustainability standards, this new coating has great potential to protect wood, whose use in construction is continually increasing. The new coating is non-toxic, hydrofobic, it retains
Similar to the election needle and the stock market index, scientists have developed a new tracking system to detect danger to rainforests around the world. The data to build the index was culled from advanced satellite measurements of climate and vegetation of each tropical region on Earth.
Last year, the American Cancer Society (ACS) issued an updated set of guidelines for cervical cancer screening – emphasizing the shift toward screening with primary human papillomavirus (HPV) testing. While the ACS recommendation accounts for a transition period to implement primary HPV screening, additional factors should be considered to operationalize these guidelines, according to a special wh
Coffee shops and casual restaurants are an important part of American life. Even beyond the food and drinks they sell, they offer us a place to use the restroom or rest our feet while we're out and about, and they provide internet access to those on the go, those in need of a temporary office, or those who don't have an internet connection at home. Many of us take for granted that a nearby Starbuc
A new study from the Annenberg School for Communication at the University of Pennsylvania investigated the ways that institutions control who has access to Wi-Fi. The findings indicate that powerful institutions and privileged people use quality-of-life policing — the report and/or arrest of individuals engaged in nonviolent offenses such as loitering, noise violations, and public intoxication —
Ruth Lipman, American Dental Association (ADA) Science and Research Institute, Chicago, Ill., U.S., presented the poster "Strategies for Disseminating Guidance to Dentists during the COVID-19 Pandemic" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental
Hiba Nasir, Wayzata High School, Plymouth, Minn., presented the poster "Oral-Health Impact Profile 5: Analyzing A Private Practice Adult Population's Distribution" at the virtual 99th General Session & Exhibition of the International Association for Dental Research (IADR), held in conjunction with the 50th Annual Meeting of the American Association for Dental Research (AADR) and the 45th Annual Me
Electromagnetic (EM) waves in the terahertz (THz) regime contribute to important applications in communications, security imaging, and bio- and chemical sensing. Such wide applicability has resulted in significant technological progress. However, due to weak interactions between natural materials and THz waves, conventional THz devices are typically bulky and inefficient. Although ultracompact act
Advanced technologies have been used to solve a long-standing mystery about why some people develop serious illness when they are infected with the malaria parasite, while others carry the infection asymptomatically.
Scientists have created plants whose cells and tissues 'blush' with beetroot pigments when they are colonized by fungi that help them take up nutrients from the soil. This is the first time this vital, 400 million year old process has been visualized in real time in full root systems of living plants. Understanding the dynamics of plant colonisation by fungi could help to make food production more
For many people, summer vacation can't come soon enough – especially for the half of Americans who canceled their summer plans last year due to the pandemic. But when a vacation approaches, do you ever get the feeling that it's almost over before it starts? If so, you're not alone. In some recent studies Gabriela Tonietto , Sam Maglio , Eric VanEpps and I conducted, we found that about half of th
Researchers have developed a methodology for avoiding conflicts of use in transboundary rivers. The model-based procedure allows for participatory planning and cooperative management of water resources.
A phenomenon known from quantum systems could now make its way into biology: Researchers show that the notion of topological protection can also apply to biochemical networks. The model which the scientists developed makes the topological toolbox, typically used only to describe quantum systems, now also available to biology.
Many species within Kenya's Tana River Basin will be unable to survive if global temperatures continue to rise as they are on track to do – according to new research. A new study outlines how remaining within the goals of the Paris Agreement would save many species. The research also identifies places that could be restored to better protect biodiversity and contribute towards global ecosystem res
The rapid spread of the Alpha variant of COVID-19 in the UK resulted from biological changes in the virus and was enhanced by large numbers of infected people 'exporting' the variant around the country, in what the researchers call a 'super-seeding' event.
The July issue of the journal CHEST® includes 85 articles, including "Pulmonary Function and Radiologic Features in Survivors of Critical COVID-19: A 3-Month Prospective Cohort," original research on critical COVID cases.
I last wrote about Deepmind's efforts to predict protein folding and structure here , with their AlphaFold software. AlphaFold really performed very strongly in the 2020 protein folding challenge, and that got a lot of attention. Well, they've recently published a great deal of detail on how they did this, released their source code, and they've announced that they're going to be releasing their
Sixty percent of students in school, college or university felt their opportunities to learn job skills worsened due to the pandemic, according to a new study led by UCL researchers. The percentage remained high even when school and colleges reopened.
Financial instability, lack of infrastructure, a deteriorating sense of community and family fragmentation are key contributors to diseases of despair in Pennsylvania communities, according to Penn State College of Medicine and Highmark Health researchers. The researchers conducted four focus groups in Pennsylvania communities identified as having high rates of despair-related illnesses.
What The Study Did: Using survey responses from students in some Pittsburgh, Pennsylvania, high schools, researchers investigated how experiences of bullying based on race/ethnicity/national origin and other marginalized identities are associated with outcomes for health, mental health and violence among adolescents.
As opioid overdose deaths rose during the COVID-19 pandemic, people seeking treatment for opioid addiction had to wait nearly twice as long to begin methadone treatment in the United States than in Canada, a new Yale study has shown.
Shields Up! The Air Force Research Lab (AFRL) seems to be working on bringing a staple of science fiction weaponry — the force field — into reality. The announcement arrived as part of a new AFRL report on the future of directed energy weapons — you know, lasers and stuff — and how they might be used by the military in the coming decades. The report concedes that developing a missile defense forc
Community policing that encourages relationships with local citizens may reduce police violence, while proactive policing strategies are associated with higher police violence, according to new Rutgers University–Camden research.
To win swimming gold in Tokyo, swimmers not only have to generate incredible power with their arms and legs to propel themselves through the water; they also have to overcome the relentless pull of the water's drag while doing so.
For young soccer players, participating in repetitive technical training activities involving heading during practice may result in more total head impacts but playing in scrimmages or actual soccer games may result in greater magnitude head impacts. That's according to a small, preliminary study released today that will be presented at the American Academy of Neurology's Sports Concussion Confere
Baseball, like many sports, sometimes seems as though it's leaving the realm of human athleticism and instead marching toward an almost technical optimization. Steroids (illicitly taken) have made some players stronger than ever. Sabermetrics, which involves the detailed statistical analysis of baseball data, has turned the artistry of staffing a team into mere mathematics, a phenomenon that the
Dig a teaspoon into your nearest clump of soil, and what you'll emerge with will contain more microorganisms than there are people on Earth. We know this from lab studies that analyze samples of earth scooped from the microbial wild to determine which forms of microscopic life exist in the world beneath our feet.
As Xi'an Jiaotong-Liverpool University researchers completed their research on colored architectural concrete, they found a surprising result—green pigmented cement had impurities that produced porous, poor quality concrete. Meanwhile, red and blue pigments had little effect.
The United States-Mexico border should be fully reopened—with people on both sides given easier and expanded access to vaccines in the U.S.—according to a new brief from Rice's Baker Institute for Public Policy.
A survey by Massey University's Healthy Work Group of more than 1400 people from 21 New Zealand workplaces has found four key features associated with positive outcomes for both employees and organizations.
About six gigatons—roughly 12 times the mass of all living humans—of carbon appears to be emitted over land every year, according to data from the Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite (TanSat).
Pandemic-induced lockdowns have provided stories of both hardship and resilience. This extends to families in the community caring for children in out-of-home care, a group which has weathered unique challenges as children are physically and sometimes virtually cut off from contact with their biological families.
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox. California, to some, is a model of what America could be. But two of our California-based writers worry that the Golden State's exceptionalism is failing. The California dream is dying. The state
Devastating floods destroyed towns in Germany and Belgium. A ruthless heat wave broiled the Western U.S. and Canada. Heavy rains paralyzed a Chinese industrial hub home to 10 million people. These recent weather phenomena are being intensified by the changing climate.
MUSC Hollings Cancer Center was one of 28 clinical sites around the world that participated in the LOTIS-2 trial to test the efficacy of Loncastuximab tesirine, a promising new treatment for aggressive B-cell lymphoma. The results of the single-arm, phase 2 trial were published online in May 2021 in Lancet Oncology.
A new radiotracer that detects iron in cancer cells has proven effective, opening the door for the advancement of iron-targeted therapies for cancer patients. The radiotracer, 18F-TRX, can be used to measure iron concentration in tumors, which can help predict whether a not the cancer will respond to treatment. This research was published in the July issue of The Journal of Nuclear Medicine.
About six gigatons — roughly 12 times the mass of all living humans — of carbon appears to be emitted over land every year, according to data from the Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite (TanSat).
Researchers from Xi'an Jiaotong-Liverpool University have found that an impurity present in many industrial pigmentations drastically reduces the strength and longevity of green architectural concrete.
Mount Sinai researchers have developed a therapeutic agent that shows high effectiveness in vitro at disrupting a biological pathway that helps cancer survive, according to a paper published in Cancer Discovery, a journal of the American Association for Cancer Research, in July.
As reported in the journal Science, Leor Weinberger and his team at Gladstone Institutes have discovered a pathway they named discordant transcription through repair (DiThR, pronounced "dither"). The DiThR pathway appears to boost the noisiness of gene expression in stem cells and enhance their ability to differentiate.
BioNyt Videnskabens Verden (www.bionyt.dk) er Danmarks ældste populærvidenskabelige tidsskrift for naturvidenskab. Det er det eneste blad af sin art i Danmark, som er helliget international forskning inden for livsvidenskaberne.
Bladet bringer aktuelle, spændende forskningsnyheder inden for biologi, medicin og andre naturvidenskabelige områder som f.eks. klimaændringer, nanoteknologi, partikelfysik, astronomi, seksualitet, biologiske våben, ecstasy, evolutionsbiologi, kloning, fedme, søvnforskning, muligheden for liv på mars, influenzaepidemier, livets opståen osv.
Artiklerne roses for at gøre vanskeligt stof forståeligt, uden at den videnskabelige holdbarhed tabes.