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GEOLOGISKE ALTIVITETER SKER I CYKLUSSER – HVORFOR VED MAN IKKE.  Scientists have finally gathered quantitative data to prove (using radio-isotopic dating) that earth's geological activities happen in cycles. Until now it was considered to be completely random events. The next step would be to find out what causes these peaks in geological activity. 

High stress may make 'broken heart syndrome' more likely, study finds
Condition also known as takotsubo cardiomyopathy is brought on by an acute emotional shock Two molecules associated with high stress levels have been implicated in the development of broken heart syndrome, a condition that mainly affects post-menopausal women and is usually brought on by severe stress, such as the loss of a loved one. The syndrome, formally known as takotsubo cardiomyopathy, is c
Pathogenic bacteria rendered almost harmless
Pseudomonas aeruginosa can cause chronic infections that are potentially fatal for people with weakened immune systems. In addition, its adaptability and resistance to many antibiotics make infections by P. aeruginosa increasingly difficult to treat. There is therefore an urgent need to develop new antibacterials. Scientists (UNIGE) have identified a previously unknown regulator of gene expression


New research adds a wrinkle to our understanding of the origins of matter in the Milky Way
New findings published this week in Physical Review Letters suggest that carbon, oxygen, and hydrogen cosmic rays travel through the galaxy toward Earth in a similar way, but, surprisingly, that iron arrives at Earth differently. Learning more about how cosmic rays move through the galaxy helps address a fundamental, lingering question in astrophysics: How is matter generated and distributed acros
How childhood exercise could maintain and promote cognitive function in later life
People who are physically active during childhood have higher cognitive functions in later life. Participants who exercised when they were children did better on cognitive tests regardless of their current age. However, no such relationship was found between task performance and post-childhood exercise — suggesting that exercise during childhood is particularly important for brain development and
'Two Americas' may emerge as Delta variant spreads and vaccination rates drop
Biden's 70% vaccination target by Fourth of July likely to fall short as efforts to entice people to get shots have lost their initial impact With Covid vaccination penetration in the US likely to fall short of Joe Biden's 70% by Fourth of July target, pandemic analysts are warning that vaccine incentives are losing traction and that "two Americas" may emerge as the aggressive Delta variant becom
Under-18s could be 'reservoirs' for virus when all adults are jabbed, expert warns
Unvaccinated children have potential to drive third wave of highly transmissible Delta variant, says virologist The drive to vaccinate all adults over the age of 18 in the UK could lead to the concentration of Covid-19 cases in schoolchildren, a leading British virologist has warned. Under-18s would then become reservoirs in which new variants of the virus could arise, said Julian Tang, of Leices
The Big Tuna Sandwich Mystery
A lawsuit against America's largest sandwich chain has raised questions about America's most popular canned fish. We tried to answer one: Is Subway selling tuna?
Chris Paul Bears the Brunt of Pro Sports' Vaccination Problem
When the NBA announced Wednesday that Phoenix Suns point guard Chris Paul was being sidelined indefinitely under the league's coronavirus-safety protocols, the next question was obvious: Had Paul been vaccinated? For COVID-19 concerns to interrupt Paul's brilliant playoff run seemed particularly cruel—not only because the widespread availability of vaccines has made transmission of the virus larg
Footprints of possibly last dinosaurs to walk Britain found in Kent
Scientists find fossilised footprints of multiple dinosaur species preserved by sediment in Folkestone Footprints of what could be the last dinosaurs to have walked in Britain have been found in Kent, researchers say. About 66m years ago, an asteroid hit the Earth and wiped out much of the Earth's dinosaurs. But flooding rendered Britain's dinosaurs extinct much earlier: about 110m years ago. Con
Blue Animals Are Different from All the Rest
Peacocks, panther chameleons, scarlet macaws, clown fish, toucans, blue-ringed octopuses, and so many more: The animal kingdom has countless denizens with extraordinarily colorful beauty. But in many cases, scientists know much more about how the animals use their colors than about how they make them. New work continues to reveal those secrets, which often depend on the fantastically precise self
Head of Independent Sage to launch international climate change group
Sir David King hopes to emulate success of British Covid advisory body by issuing monthly reports on environmental crisis Several of the world's leading scientists plan to launch an independent expert group this week to advise, warn and criticise global policymakers about the climate and nature crises. The new body has been inspired by Independent Sage – the cluster of British scientists who have
Robin Wall Kimmerer: 'Mosses are a model of how we might live'
The moss scientist and bestselling author reveals the secrets of these primitive plants – and what they might teach us about surviving the climate crisis Robin Wall Kimmerer can recall almost to the day when she first fell under the unlikely spell of moss. "It's kind of embarrassing," she says. "I've always been engaged with plants, because I grew up in the countryside. That was my world. But mos
The best coding toys for kids
Whether or not your child is totally interested in computers or they are just curious kids, Prime Day could be the perfect time to introduce them to some of the best coding toys around.
How a cancer diagnosis inspired a fresh outlook for one young musician
At the age of just 22, the very last thing you want to hear is that you have stage 4 cancer, but for some people the only response is to tackle it head on – which is just what Ellie Edna Rose-Davies did I barely noticed it at first. A bump on the right side of my neck, small but definite. I was 22 and had no health issues (I'd never even broken a bone), so I didn't think much of the lump. But my
Giles Yeo: 'Let's consider the type of food we eat, and not fixate on calories'
The scientist and broadcaster discusses the drawbacks of calorie-counting and BMI in measuring obesity, and how our growing understanding of genetics is leading to new treatments Since the dawn of the 20th century, almost all weight loss guidelines have used calories as a simple measure of how much energy we're consuming from our food. But according to Giles Yeo, a Cambridge University research s
Sunday with Tim Peake: 'I'm a dreadful chef, but I can do a roast'
The astronaut reveals why he likes nothing more than a nice and relaxed down-to-earth day with the kids What time do you get up? Whatever time my youngest comes bouncing into the room. He's nine and has an uncanny ability to sleep in on school days and wake up early on weekends. What's for breakfast? We'll make pancakes with blueberries and raspberries. We've got a little pancake maker – it's fun
Researchers find optimal way to pay off student loans
After graduating or leaving college, many students face a difficult choice: Try to pay off their student loans as fast as possible to save on interest, or enroll in an income-based repayment plan, which offers affordable payments based on their income and forgives any balance remaining after 20 or 25 years.
Meet the worm with a jaw of metal
Bristle worms are odd-looking, spiky, segmented worms with super-strong jaws. Researchers have discovered that the jaws contain metal. It appears that biological processes could one day be used to manufacture metals. The bristle worm, also known as polychaetes , has been around for an estimated 500 million years. Scientists believe that the super-resilient species has survived five mass extinctio
The Real Problem With Globalization
F ew ideas today are more unfashionable than globalization. Across the ideological spectrum, a once-robust consensus about the liberating power of free trade and financial markets has transformed into the conviction that the world has spun out of control. Economic inequality is rising in developing and developed countries alike. Hopes for a global human-rights awakening have given way to frank as
This Week's Awesome Tech Stories From Around the Web (Through June 19)
FUTURE OF WORK Kill the 5-Day Work Week Joe Pinsker | The Atlantic "People who work a four-day week generally report that they're healthier, happier, and less crunched for time; their employers report that they're more efficient and more focused. These companies' success points to a tantalizing possibility: that the conventional approach to work and productivity is fundamentally misguided." TRANS
Modern China's First Diplomats
W hen Chinese diplomats arrived in New York in 1971, they might as well have landed on another planet. The United Nations had just transferred China's seat at the global body from Taipei to Beijing, a momentous step. Yet what first struck many of these new arrivals were the colors. On clothing, in shop fronts, and on neon signs, they saw a world that seemed physically and even morally jarring com
Children of obese mums at higher risk of fatty liver disease – study
Researchers say influences in the womb may play a role in increasing the risk of developing the condition Children of obese mothers have a greater risk of developing fatty liver disease in their 20s, according to researchers who say policymakers need to do more to tackle the promotion of poor-quality food and drink. Non-alcoholic fatty liver disease (NAFLD) can be caused by obesity . If it progre
Ask Philippa: meet the Observer's brilliant new agony aunt
As psychotherapist and author Philippa Perry becomes our new agony aunt, she reveals why helping you with your worries will help us all. Plus, a special welcome from Jay Rayner John Dunton founded the Athenian Mercury in the 1690s. A paper that consisted of readers' questions and the answers. His idea was that readers could send in dilemmas to be answered by a panel of experts, the Athenian Socie
The Vaccine Donations Aren't Enough
Developing countries now account for more of the COVID-19s daily global death toll, at 85 percent and climbing, than high-income countries. Thanks to high vaccination rates, deaths in these rich countries have fallen from 59 to 15 percent of the global share, an all-time low, according to the Brookings Institution . The signs of this switch are jarring. Vaccinated Americans are reading up on how
Proliferation of electric vehicles based on high-performance, low-cost sodium-ion battery
Various automobile companies are preparing to shift from internal combustion (IC) engine vehicles to electric vehicles (EVs). However, due to higher cost, EVs are not as easily accessible to consumers; hence, several governments are subsidizing EVs to promote sales. For EV costs to compete with those of IC engine vehicles, their batteries, which account for about 30% of their cost, must be more ec
Memory helps us evaluate situations on the fly, not just recall the past
Scientists have long known the brain's hippocampus is crucial for long-term memory. Now a new study has found the hippocampus also plays a role in short-term memory and helps guide decision-making. The findings shed light on how the hippocampus contributes to memory and exploration, potentially leading to therapies that restore hippocampal function, which is impacted in memory-related aging and ne
Graphene drum: A new phonon laser design
Professor Konstantin Arutyunov of the HSE Tikhonov Moscow Institute of Electronics and Mathematics (MIEM HSE), together with Chinese researchers, has developed a graphene-based mechanical resonator, in which coherent emission of sound energy quanta, or phonons, has been induced. Such devices, called phonon lasers, have wide potential for application in information processing, as well as classical
TV Can't Stop Thinking About the Female Gaze
T he creators of Kevin Can F**k Himself have yet to go on the record about this, but they're clearly tired of lopsided sitcom marriages. The series, with its pointed title, seems to be a roast of shows starring the comedian Kevin James over the years, such as The King of Queens; notably, his characters' spouses didn't have lives of their own outside of doting on him. (One even got unceremoniously
Separating natural and anthropogenic pollutants in the air
COVID-19 has changed the world in unimaginable ways. Some have even been positive, with new vaccines developed in record time. Even the extraordinary lockdowns, which have had severe effects on movement and commerce, have had beneficial effects on the environment and therefore, ironically, on health. Studies from all around the world, including China, Europe and India, have found major drops in th
New technique allows for identification of potential drugs to fight resistant bacteria
Researchers have optimized a new technique that will allow scientists to evaluate how potential inhibitors work on antibiotic-resistant bacteria. This technique, called native state mass spectrometry, provides a quick way for scientists to identify the best candidates for effective clinical drugs, particularly in cases where bacteria can no longer be treated with antibiotics alone.
ISS astronauts complete six-hour spacewalk to install solar panels
Successful International Space Station installation followed an attempt on Wednesday that ran into several problems French and American astronauts have completed a six-hour spacewalk as they installed new solar panels to boost power supplies to the International Space Station (ISS), Nasa said. "It is a huge team effort each time and couldn't be happier to return with @astro_kimbrough," Frenchman
Janet Malcolm the Magician
There are two kinds of magicians: Those who purport to be doing something truly supernatural, drawing on the paranormal, and those who are honest with their audiences about fooling them. Janet Malcolm, who died last week at 86, was of the second type. Her journalism was filled with instances in which she alerted readers that she would be playing with their minds; she then did so effortlessly. Kno
Volcanoes to power bitcoin mining in El Salvador
This article was originally published on our sister site, Freethink. In June 2021, El Salvador became the first nation in the world to make bitcoin legal tender. Soon after, President Nayib Bukele instructed a state-owned power company to provide bitcoin mining facilities with cheap, clean energy — harnessed from the country's volcanoes. The challenge: Bitcoin is a cryptocurrency , a digital form
How Pfizer and BioNTech made history with their vaccine
Wondering how Pfizer and partner BioNTech developed a COVID-19 vaccine in record time without compromising safety? Dr Bill Gruber, SVP of Pfizer Vaccine Clinical Research and Development, explains the process from start to finish. "I told my team, at first we were inspired by hope and now we're inspired by reality," Dr Gruber said. "If you bring critical science together, talented team members to
Each of These Microscopic Glass Beads Stores an Image Encoded on a Strand of DNA
Increasingly, civilization's information is stored digitally, and that storage is abundant and growing. We don't bother deleting those seven high-definition videos of the ceiling or 20 blurry photos of a table corner taken by our kid. There's plenty of room on a smartphone or in the cloud, and we count on both increasing every year. As we fluidly copy information from device to device, this situa
Stronger together: How protein filaments interact
Just as the skeleton and muscles move the human body and hold its shape, the cells of the body are stabilized and moved by a cellular skeleton. This cellular skeleton is a dynamic structure, constantly changing and renewing. It consists of different types of protein filaments, which include intermediate filaments and microtubules. Researchers have now observed and measured a direct interaction bet
Readers reply: is ignorant bliss better than knowledgeable gloom?
The long-running series in which readers answer other readers' questions on subjects ranging from trivial flights of fancy to profound scientific and philosophical concepts Happier people live longer, more pleasant lives. Informed people are weighed down with the woes of the world. So, is ignorant bliss better than knowledgeable gloom? Mary Shider, Macclesfield Send new questions to nq@theguardia
This Groundbreaking Eye Health Supplement Protects Against Screen Time Eye Stress
The average worker spends seven hours a day staring at a digital screen . Then, they spend their downtime concentrating on their tablet, phone or television. That's a lot of hours to be focused on a screen. Especially since the LEDs used to emit light from these screens are a visual stressor that causes eye strain. This screen time eye stress can manifest as any of the following symptoms, or a co
Water in the American Southwest
The American Southwest is iconic. How many of us native northerners marveled each year at the beauty of the Rose Bowl as we shivered in -30F January? The Southwest is in desperate need of water. Personally, I want the US Southwest to survive and thrive. I want to be able to go there on vacation during the winter months. I believe we need a system of pipelines to relieve the Southeastern part of t
The Yoga RCT
Back in December, 2020, Chief Scientist for the WHO Dr. Soumya Swaminathan tweeted about a study that suggested yoga helped improve various blood markers in people with diabetes. However, a major flaw prevents the study from being rigorous enough to believe its conclusions. The post first appeared on Science-Based Medicine .
During COVID-19 pandemic, increased screen time correlates with mental distress
Increased screen time among young adults during the COVID-19 pandemic correlated with a rise in pandemic-related distress, according to research led by investigators at the Saint James School of Medicine on the Caribbean island nation, Saint Vincent. The increase in time spent viewing entertainment on a screen both prior to and during the pandemic was associated with a boost in anxiety scores.
Film recommendations
Hi everyone, I'd love to hear your recommendations for futuristic scifi films, as well as any recommended documentaries with a bent toward futurology. Thanks! submitted by /u/rustyfinch [link] [comments]
Se hur storstaden förändrar djuren
Djur och växter som har flyttat in i människans städer visar en stor förmåga att anpassa sig till de nya omständigheterna. Forskarna kan nu se evolutionens verkan i realtid i allt från parkernas fåglar till gräsmattornas klöverängar. Spela klippet och se hur tre olika arter har anpassat sig till storstaden.
New therapeutic target for C. difficile infection
A new study paves the way for the development of next generation therapeutics for the prevention and treatment of Clostridioides difficile infection (CDI), the most frequent cause of healthcare-acquired gastrointestinal infections and death in developed countries.
Dragonflies: Species losses and gains in Germany
Over the past 35 years, there have been large shifts in the distributions of many dragonfly species in Germany. Those of standing water habitats have declined, probably due to loss of habitat. Running-water species and warm-adapted species have benefited from improved water quality and warmer temperatures. The study highlights the importance of citizen science and natural history societies for lon
Atomic-scale tailoring of graphene approaches macroscopic world
Properties of materials are often defined by imperfections in their atomic structure, especially when the material itself is just one atom thick, such as graphene. Researchers have now developed a method for controlled creation of such imperfections into graphene at length scales approaching the macroscopic world. These results, confirmed by atomically resolved microscope images, serve as an essen
Will reduction in tau protein protect against Parkinson's and Lewy body dementias?
Will a reduction in tau protein in brain neurons protect against Parkinson's disease and Lewy body dementias? A new study suggests the answer is no. If this is borne out, that result differs from Alzheimer's disease, where reducing endogenous tau levels in brain neurons is protective for multiple models of the disease — and thus suggests that the role of tau in the pathogenesis of Lewy body demen
Start-stop system of hunting immune cells
Researchers decipher the basic biology of neutrophil swarming and now show that the cells also evolved an intrinsic molecular program to self-limit their swarming activity. The study elucidates how swarming neutrophils become insensitive to their own secreted signals that brought the swarm together in the first place. This process is crucial for the efficient elimination of bacteria in tissues.
The Great Unsolved Problems of Material Science
Progress in bringing new materials to market is agonizingly slow these days. In 1935, Dupont scientists discovered a new synthetic fiber, just 3 years later it was being mass produced under the name "Nylon". In 2004, researchers at the University of Manchester discovered how to create atom thick sheets of carbon. They named their substance Graphene. 17 years later, you definitely don't own any pr
What are Doomers and Doomscrolling, and how do they correlate with Climate Change?
I've seen the terms "doomer, and "doomist" floating around a lot lately, especially regarding the sub r/collapse , I've read upon the terms, but I seek deeper understanding of the subject matter. Especially after reading the article about the record level drought/heatwave, and the honestly terrifying comment section connected to it. Furthermore are things really this bad that we should lose all h
is cannabis being pushed to legalization due to economic reasons?
as part of my academic study I am trying to name the reasons for the growing acceptance of states and social acceptance of the substance. I noticed that the strongest confirmed reason for this changing trend is due to the media's positive coverage of psychedelic drugs. I would like to investigate whether the change in state's policies is due to economic reasons rather than social reasons. does an
Astronomers find more than 100,000 "stellar nurseries"
This article was originally published on our sister site, Freethink. An international team of astronomers has conducted the biggest survey of stellar nurseries to date, charting more than 100,000 star-birthing regions across our corner of the universe. Stellar nurseries: Outer space is filled with clouds of dust and gas called nebulae. In some of these nebulae, gravity will pull the dust and gas
Managed retreat: A must in the war against climate change
Climate change will shape the future of coastal communities, with flood walls, elevated structures and possibly even floating cities used to combat sea level rise. New research has found that managed retreat — moving buildings, homes or communities off of the coast or away from floodplains — must be part of any solution.
Swim first, hunt later: Young Weddell seals need to practice navigating before hunting
Weddell seals, the southernmost born mammal, are known as champion divers. But they don't begin life that way. Researchers examined the development of diving behavior in Weddell seal pups and found that they time their dives with their mother but likely do not learn to forage at that time. Instead, they focus their early efforts on learning to swim and navigate under the sea ice.
Researchers discover the physics of foams
Chemical engineers have answered longstanding questions about the underlying processes that determine the life cycle of liquid foams. The breakthrough could help improve the commercial production and application of foams in a broad range of industries.
Protecting space stations from deadly space debris
NASA estimates that more than 500,000 pieces of space trash larger than a marble are currently in orbit. Estimates exceed 128 million pieces when factoring in smaller pieces from collisions. At 17,500 MPH, even a paint chip can cause serious damage. To prevent this untrackable space debris from taking out satellites and putting astronauts in danger, scientists have been working on ways to retriev
Weekend reads: Biotech CEO on leave after allegations on PubPeer; a researcher disavows his own paper; plagiarism here, there, and everywhere
Before we present this week's Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured: 'A costly mistake' prompts retraction of paper on hair loss … Continue reading
Ugens debat: Er kørselsafgifter vejen frem?
Med sin nye klimaplan lægger IDA op til mere cyklisme og kollektiv trafik, hvilket vil kræve en omlægning fra bil- til kørselsafgifter. I debatten på affødte det både kritik og mange alternative forslag.
Storm expected to be another blow to Gulf Coast businesses
A weekend that was supposed to be filled with celebrations of Juneteenth and Father's Day has turned dreary in coastal Louisiana and Mississippi, where an unpredictable tropical weather system has brought wind, heavy rain and fears of flooding to a region where some have sandbags still left over from last year's record-breaking hurricane season.
What the hell is up with reddit?
I'm not sure if this fits here but I regularly see people who think the world is gonna end. I get that climate change does have the potential to end the world and if people do keep being ignorant it will. I see that. What I don't understand though is the people who actually want the world to end. I don't see why you would go on futurology and actively want the world to end. Respect to people who
Psykoser splittrar tolvbarnsfamilj
Familjen Galvin består av makarna Don och Mimi och deras tolv barn, tio söner och två döttrar födda mellan 1945 och 1965. På ytan är Galvins en katolsk mönsterfamilj. Bakom fasaden råder kaos till följd av att ett efter ett av barnen försvinner in i vanföreställningar. Sammanlagt sex pojkar får diagnosen schizofreni. Flickorna klarar sig. Huvudfokus ligger på yngsta dottern Mary. Hon pendlar mella
Blackologists and the Promise of Inclusive Sustainability
Historically, shared resources have often been managed with an aim toward averting "tragedies of the commons," which are thought to result from selfish overuse. Writing in BioScience (, Drs. Senay Yitbarek, Karen Bailey, Nyeema Harris, and colleagues critique this model, arguing that, all too often, such conservation has
The End of Reductionism Could Be Nigh. Or Not. – Facts So Romantic
Quantum mechanics seems to have a problem with the order of time, which might signal the need for an entirely new type of law. Illustration by Ekaterina Kulaeva / Shutterstock The history of science so far has been a triumph of reductionism. Biology can be reduced to chemistry, chemistry can be reduced to atomic physics, and atoms are made of elementary particles like electrons, quarks, and gluon
In the visual thalamus, neurons are in contact with both eyes but respond to only one
The visual thalamus is classically known to relay visual stimuli coming from the retina to the cerebral cortex. Researchers now show that although neurons in the mouse visual thalamus connect to both eyes, they establish strong functional connections only with one retina. These results settle partly contradictory results of earlier studies and demonstrate how important it can be to complement stru
Sacred natural sites protect biodiversity in Iran
How much do traditional practices contribute to the protection of local biodiversity? Why and how are sacred groves locally valued and protected, and how can this be promoted and harnessed for environmental protection? Researchers have examined the backgrounds of this form of local environmental protection in Baneh County, Iran.
This Revolutionary Mouthpiece Fights the Effects of Sleep Apnea and Snoring
It's bedtime , but you know you won't be sleeping since your significant other snores. If you're partners with one of the 50-percent of men or 24-percent of women who snore , you already know the strain it can have on your relationship. In fact, snoring is the third leading cause of divorce in the United States with 56-percent of snorer's partners claiming it has an adverse effect on their well b
The end of Darwin's nightmare at Lake Victoria?
Lake Victoria, which came under the spotlight in 2004 by the documentary 'Darwin's nightmare', is not only suffering from the introduction and commercialization of the Nile perch: A study has highlighted other worrying phenomena, particularly climatic ones, which have an equally important impact on the quality of the lake's waters.
Researchers: Career metrics uphold racism, sexism in science
The metrics that mark career success for researchers are biased against already marginalized groups in science, say 24 researchers. The criteria that measure progress—or lack thereof—include how often a researcher's studies are cited by other scientists, and the number of papers they publish in prestigious, high-impact scientific journals (which often comes with an expensive price tag paid by a p
Future predictions that turned out hilariously wrong
Recently re-read George Friedmanns "The next 100 years" – so far his record is less than stellar – more like 99% wrong. So is Gerald Celente and Peter Turchin and H.G. Wells. What are some other sci-fi authors/futurologists that made predictions that turned out hilariously wrong? submitted by /u/AlexanderDenorius [link] [comments]
Scott Taylor vs. Murder Nova | Street Outlaws: America's List
Stream Full Episodes of Street Outlaws: America's List: discovery+ ► Discovery ► Subscribe to Discovery: Follow Us on TikTok: We're on Instagram! Join Us on Facebook: https
What Juneteenth teaches us about emancipation
For historian Julie Saville, the celebration of Juneteenth highlights the work that was required to secure freedom for enslaved Black people. "The people of Texas are informed that, in accordance with a proclamation from the Executive of the United States, all slaves are free." Thus declared Major General Gordon Granger of the Union Army on June 19, 1865, reading aloud an order of emancipation in
'Doomsday Glacier' may be more stable than feared
The world's largest ice sheets may be in less danger of sudden collapse than previously predicted, according to a new study. The study in Science includes simulating the demise of West Antarctica's Thwaites Glacier, one of the world's largest and most unstable glaciers. Researchers modeled the collapse of various heights of ice cliffs—near-vertical formations that occur where glaciers and ice she
CD8+ T cell immunity blocks the metastasis of carcinogen-exposed breast cancer
The link between carcinogen exposure and cancer immunogenicity is unclear. Single exposure to 12-dimethylbenz[a]anthracene (DMBA) at puberty accelerated spontaneous breast carcinogenesis in mouse mammary tumor virus-polyoma middle tumor-antigen transgenic (MMTV-PyMT tg or PyMT) and MMTV-Her2/neu tg (Her2) mice. Paradoxically, DMBA-treated PyMT and Her2 animals were protected from metastasis. CD8
ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication
53BP1 activates nonhomologous end joining (NHEJ) and inhibits homologous recombination (HR) repair of DNA double-strand breaks (DSBs). Dissociation of 53BP1 from DSBs and consequent activation of HR, a less error-prone pathway than NHEJ, helps maintain genome integrity during DNA replication; however, the underlying mechanisms are not fully understood. Here, we demonstrate that E3 ubiquitin ligas
Two mechanisms of chromosome fragility at replication-termination sites in bacteria
Chromosomal fragile sites are implicated in promoting genome instability, which drives cancers and neurological diseases. Yet, the causes and mechanisms of chromosome fragility remain speculative. Here, we identify three spontaneous fragile sites in the Escherichia coli genome and define their DNA damage and repair intermediates at high resolution. We find that all three sites, all in the region
The Boltysh impact structure: An early Danian impact event during recovery from the K-Pg mass extinction
Both the Chicxulub and Boltysh impact events are associated with the K-Pg boundary. While Chicxulub is firmly linked to the end-Cretaceous mass extinction, the temporal relationship of the ~24-km-diameter Boltysh impact to these events is uncertain, although it is thought to have occurred 2 to 5 ka before the mass extinction. Here, we conduct the first direct geochronological comparison of Boltys
Probing the in-plane liquid-like behavior of liquid crystal elastomers
When isotropic solids are unequally stretched in two orthogonal directions, the true stress (force per actual cross-sectional area) in the larger strain direction is typically higher than that in the smaller one. We show that thiol-acrylate liquid crystal elastomers with polydomain texture exhibit an unusual tendency: The true stresses in the two directions are always identical and governed only
Structural insights into the recognition of histone H3Q5 serotonylation by WDR5
Serotonylation of histone H3Q5 (H3Q5ser) is a recently identified posttranslational modification of histones that acts as a permissive marker for gene activation in synergy with H3K4me3 during neuronal cell differentiation. However, any proteins that specifically recognize H3Q5ser remain unknown. Here, we found that WDR5 interacts with the N-terminal tail of histone H3 and functions as a "reader"
Viral infection of algal blooms leaves a unique metabolic footprint on the dissolved organic matter in the ocean
Algal blooms are hotspots of primary production in the ocean, forming the basis of the marine food web and fueling the dissolved organic matter (DOM) pool. Viruses are key players in controlling algal demise, thereby diverting biomass from higher trophic levels to the DOM pool, a process termed the "viral shunt." To decode the metabolic footprint of the viral shunt in the environment, we induced
p53 loss activates prometastatic secretory vesicle biogenesis in the Golgi
Cancer cells exhibit hyperactive secretory states that maintain cancer cell viability and remodel the tumor microenvironment. However, the oncogenic signals that heighten secretion remain unclear. Here, we show that . p53 loss up-regulates the expression of a Golgi scaffolding protein, progestin and adipoQ receptor 11 (PAQR11), which recruits an adenosine diphosphate ribosylation factor 1–contain
Rapid coordination of effective learning by the human hippocampus
Although the human hippocampus is necessary for long-term memory, controversial findings suggest that it may also support short-term memory in the service of guiding effective behaviors during learning. We tested the counterintuitive theory that the hippocampus contributes to long-term memory through remarkably short-term processing, as reflected in eye movements during scene encoding. While view
Revealing generation, migration, and dissociation of electron-hole pairs and current emergence in an organic photovoltaic cell
Using an innovative quantum mechanical method for an open quantum system, we observe in real time and space the generation, migration, and dissociation of electron-hole pairs, transport of electrons and holes, and current emergence in an organic photovoltaic cell. Ehrenfest dynamics is used to study photoexcitation of thiophene:fullerene stacks coupled with a time-dependent density functional tig
Control of intestinal inflammation by glycosylation-dependent lectin-driven immunoregulatory circuits
Diverse immunoregulatory circuits operate to preserve intestinal homeostasis and prevent inflammation. Galectin-1 (Gal1), a β-galactoside–binding protein, promotes homeostasis by reprogramming innate and adaptive immunity. Here, we identify a glycosylation-dependent "on-off" circuit driven by Gal1 and its glycosylated ligands that controls intestinal immunopathology by targeting activated CD8 + T

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