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Nyheder2021maj22

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POLEN VIL PRODUCERE SOLPANELER: With a relatively new developed process method for production of solar panels, there is a plan in place to start their production in Poland. That will bring Poland a huge step forward for green energy and more accessible solar energy in Europe.

https://techxplore.com/news/2021-05-firm-cutting-edge-solar-energy.html

 

PARTIKELFYSIKERE VIL STUDERE DE SÅKALDTE BOSON-ELEMENTER PÅ EN NY MÅDE: Scientists are using new approaches in studying the Higgs boson. With combinations of the new approaches, they can get a clearer understanding of production and decay of the boson. In future this might lead to finding not yet discovered elements of the Standard module. 

https://phys.org/news/2021-05-deeper-insight-higgs-boson-production.html

 

1888: Nye dampsprøjter yder 1600 potter pr. minut
Den nordiske Industri-, Landbrugs- og Kunstudstilling i København bragte to smukke prøver på, hvor fremskreden teknikken er inden for brandsprøjter, skrev Ingeniøren i 1888. I samme nummer kan man desuden læse om de nyeste valsestole, dampmaskiner samt vind-, gas- og petroleumsmotorer.
10h
I genteknikens hetluft
Efter hyllade biografier om bland andra Apples grundare Steve Jobs och universalgeniet Leonardo da Vinci tar sig den amerikanska författaren Walter Isaacson an gentekniken. Huvudperson i den nya biografin, The code breaker, är Jennifer Doudna, en av forskarna bakom gensaxen crispr. Valet är vältajmat. Boken hamnar mitt i den genetiska hetluften.
13h
Geologi som äventyrshistoria
Vi människor lever på en planet. Det borde vara uppenbart, men ofta är det uppenbara osynligt tills någon pekar ut det. Lewis Dartnell lyckas verkligen med detta i sin bok Ursprung. Hur människan utvecklades som art, vad vi kom att äta och bygga av och vilka verktyg vi har utvecklat – allt formas av planetens förutsättningar. Geografin är byggd på geologi, kemi och klimatsystem.
13h
Lär av naturen
Genom att studera hur djur och växter fungerar och samverkar kan människor hitta lösningar på olika problem. Vi behöver naturen som läromästare mer än någonsin för att skapa ett hållbart samhälle, menar biologen Fredrik Moberg, författare till boken Den uppfnningsrika planeten.
13h
Finer touch for tuning stem cell "fate" with substrates of varying stiffness
Researchers from Tokyo Metropolitan University have been quantifying how different batches of mesenchymal stem cells respond to the mechanical stiffness of their environments. They focused on how certain proteins were "localized" in cell nuclei and found key trends in how this changed with stiffness. Their findings explain inconsistencies between previous findings and may guide how scientists cont
14h
Smart toilet may soon analyze stool for health problems
An artificial intelligence tool under development at Duke University can be added to the standard toilet to help analyze patients' stool and give gastroenterologists the information they need to provide appropriate treatment, according to research that was selected for presentation at Digestive Disease Week® (DDW) 2021. The new technology could assist in managing chronic gastrointestinal issues su
14h
Vast under-treatment of diabetes seen in global study
Nearly half a billion people have diabetes, but most aren't getting the kind of care that could make their lives healthier, longer and more productive, according to a new global study of data from people with the condition. Many don't even know they have the condition.Only 1 in 10 people with diabetes in the 55 low- and middle-income countries studied receive the type of comprehensive care that's
20h
Dealing with Misuse of Robots by politicians and governments
A lot of people like to assume that AI is going to be the downfall of humanity, but when you look through history, technology and science only truly threatens humanity's existence and freedoms when the politicians get involved. As two simple examples: nuclear energy, which was supposed to be just an unlimited source of energy was used by the United States government to murder thousands of people
21h
Preventing the spread of plant pandemics
Plant diseases don't stop at national borders and miles of oceans don't prevent their spread, either. That's why plant disease surveillance, improved detection systems, and global predictive disease modeling are necessary to mitigate future disease outbreaks and protect the global food supply, according to a team of researchers in a new commentary published in Proceedings of the National Academy o
21h
Arctic soil patterns analogous to fluid instabilities [Earth, Atmospheric, and Planetary Sciences]
Slow-moving arctic soils commonly organize into striking large-scale spatial patterns called solifluction terraces and lobes. Although these features impact hillslope stability, carbon storage and release, and landscape response to climate change, no mechanistic explanation exists for their formation. Everyday fluids—such as paint dripping down walls—produce markedly similar fingering patterns res
22h
Nanofiber filter captures almost 100 percent of coronavirus aerosols in experiment
A filter made from polymer nanothreads blew three kinds of commercial masks out of the water by capturing 99.9 percent of coronavirus aerosols in an experiment. The study compared the effectiveness of surgical and cotton masks, a neck gaiter, and electrospun nanofiber membranes. The cotton mask and neck gaiter only removed about 45 percent to 73 percent of the aerosols. The surgical mask did much
23h
The Mirror Home Gym Lets You Say Goodbye to Health Clubs Once and for All
If you were forced to switch to an at-home workout in 2020, you're not alone. In fact, even prior to the pandemic, many people were choosing to build the perfect at-home gym so they could conveniently exercise around their busy schedules. However, since the start of the pandemic, 60-percent of Americans found they enjoyed working out at home so much, they have no plans to return to the gym… ever
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Optical computation of a spin glass dynamics with tunable complexity [Applied Physical Sciences]
Spin glasses (SGs) are paradigmatic models for physical, computer science, biological, and social systems. The problem of studying the dynamics for SG models is nondetermistic polynomial-time (NP) hard; that is, no algorithm solves it in polynomial time. Here we implement the optical simulation of an SG, exploiting the N segments…
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Nanoparticle-enabled innate immune stimulation activates endogenous tumor-infiltrating T cells with broad antigen specificities [Immunology and Inflammation]
Tumors are often infiltrated by T lymphocytes recognizing either self- or mutated antigens but are generally inactive, although they often show signs of prior clonal expansion. Hypothesizing that this may be due to peripheral tolerance, we formulated nanoparticles containing innate immune stimulants that we found were sufficient to activate self-specific…
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Dynamic population stage structure due to ȷuvenile-adult asymmetry stabilizes complex ecological communities [Ecology]
Natural ecological communities are diverse, complex, and often surprisingly stable, but the mechanisms underlying their stability remain a theoretical enigma. Interactions such as competition and predation presumably structure communities, yet theory predicts that complex communities are stable only when species growth rates are mostly limited by intraspecific self-regulation rather than…
1d
Random heterogeneity outperforms design in network synchronization [Applied Physical Sciences]
A widely held assumption on network dynamics is that similar components are more likely to exhibit similar behavior than dissimilar ones and that generic differences among them are necessarily detrimental to synchronization. Here, we show that this assumption does not generally hold in oscillator networks when communication delays are present….
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Elementary mechanisms of calmodulin regulation of NaV1.5 producing divergent arrhythmogenic phenotypes [Physiology]
In cardiomyocytes, NaV1.5 channels mediate initiation and fast propagation of action potentials. The Ca2+-binding protein calmodulin (CaM) serves as a de facto subunit of NaV1.5. Genetic studies and atomic structures suggest that this interaction is pathophysiologically critical, as human mutations within the NaV1.5 carboxy-terminus that disrupt CaM binding are linked…
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Structure of Ycf1p reveals the transmembrane domain TMD0 and the regulatory region of ABCC transporters [Biochemistry]
ATP binding cassette (ABC) proteins typically function in active transport of solutes across membranes. The ABC core structure is composed of two transmembrane domains (TMD1 and TMD2) and two cytosolic nucleotide binding domains (NBD1 and NBD2). Some members of the C-subfamily of ABC (ABCC) proteins, including human multidrug resistance proteins…
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Hydrodynamic shear dissipation and transmission in lipid bilayers [Biophysics and Computational Biology]
Vital biological processes, such as trafficking, sensing, and motility, are facilitated by cellular lipid membranes, which interact mechanically with surrounding fluids. Such lipid membranes are only a few nanometers thick and composed of a liquid crystalline structure known as the lipid bilayer. Here, we introduce an active, noncontact, two-point microrheology…
1d
Flexoelectricity in soft elastomers and the molecular mechanisms underpinning the design and emergence of giant flexoelectricity [Applied Physical Sciences]
Soft robotics requires materials that are capable of large deformation and amenable to actuation with external stimuli such as electric fields. Energy harvesting, biomedical devices, flexible electronics, and sensors are some other applications enabled by electroactive soft materials. The phenomenon of flexoelectricity is an enticing alternative that refers to the…
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The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-I [Microbiology]
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and has claimed over 2 million lives worldwide. Although the genetic sequences of SARS-CoV and SARS-CoV-2 have high homology, the clinical and pathological characteristics of COVID-19 differ significantly from those of SARS. How and whether…
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Entire genome from Pestera Muierii 1 sequenced
Researchers have successfully sequenced the entire genome from the skull of Pestera Muierii 1, a woman who lived in today's Romania 35,000 years ago. Her high genetic diversity shows that the out of Africa migration was not the great bottleneck in human development but rather this occurred during and after the most recent Ice Age.
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Chromatin-associated MRN complex protects highly transcribing genes from genomic instability
MRN-MDC1 plays a central role in the DNA damage response (DDR) and repair. Using proteomics of isolated chromatin fragments, we identified DDR factors, such as MDC1, among those highly associating with a genomic locus upon transcriptional activation. Purification of MDC1 in the absence of exogenous DNA damage revealed interactions with factors involved in gene expression and RNA processing, in ad
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Five years of whole-soil warming led to loss of subsoil carbon stocks and increased CO2 efflux
Subsoils below 20 cm are an important reservoir in the global carbon cycle, but little is known about their vulnerability under climate change. We measured a statistically significant loss of subsoil carbon (–33 ± 11%) in warmed plots of a conifer forest after 4.5 years of whole-soil warming (4°C). The loss of subsoil carbon was primarily from unprotected particulate organic matter. Warming also
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Nonreplicable publications are cited more than replicable ones
We use publicly available data to show that published papers in top psychology, economics, and general interest journals that fail to replicate are cited more than those that replicate. This difference in citation does not change after the publication of the failure to replicate. Only 12% of postreplication citations of nonreplicable findings acknowledge the replication failure. Existing evidence
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Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells
The PDL1-PD1 immune checkpoint inhibits T cell activation, and its blockade is effective in a subset of patients. Studies are investigating how checkpoints are hijacked by cancer cells and why most patients remain resistant to immunotherapy. Epithelial mesenchymal transition (EMT), which drives tumor cell invasion via the Zeb1 transcription factor, is linked to immunotherapy resistance. In additi
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Air pollution impacts of COVID-19-related containment measures
Responses to the COVID-19 outbreak resulted in one of the largest short-term decreases in anthropogenic emissions in modern history. To date, there has been no comprehensive assessment of the impact of lockdowns on air quality and human health. Using global satellite observations and ground measurements from 36 countries in Europe, North America, and East Asia, we find that lockdowns led to reduc
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FluoSTEPs: Fluorescent biosensors for monitoring compartmentalized signaling within endogenous microdomains
Growing evidence suggests that many essential intracellular signaling events are compartmentalized within kinetically distinct microdomains in cells. Genetically encoded fluorescent biosensors are powerful tools to dissect compartmentalized signaling, but current approaches to probe these microdomains typically rely on biosensor fusion and overexpression of critical regulatory elements. Here, we
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Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and {beta}-amyloid pathology
Aging leads to a progressive deterioration of meningeal lymphatics and peripheral immunity, which may accelerate cognitive decline. We hypothesized that an age-related reduction in C-C chemokine receptor type 7 (CCR7)–dependent egress of immune cells through the lymphatic vasculature mediates some aspects of brain aging and potentially exacerbates cognitive decline and Alzheimer's disease–like br
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Myeloid-derived growth factor inhibits inflammation and alleviates endothelial injury and atherosclerosis in mice
Whether bone marrow modulates systemic metabolism remains unknown. Here, we found that (i) myeloid cell–specific myeloid-derived growth factor (MYDGF) deficiency exacerbated vascular inflammation, adhesion responses, endothelial injury, and atherosclerosis in vivo. (ii) Myeloid cell–specific MYDGF restoration attenuated vascular inflammation, adhesion responses and leukocyte homing and alleviated
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A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery
Cell division cycle 7 (CDC7), a serine/threonine kinase, plays important roles in DNA replication. We developed a highly specific CDC7 inhibitor, TAK-931, as a clinical cancer therapeutic agent. This study aimed to identify the potential combination partners of TAK-931 for guiding its clinical development strategies. Unbiased high-throughput chemical screening revealed that the highest synergisti
1d
Gas-phase synthesis of benzene via the propargyl radical self-reaction
Polycyclic aromatic hydrocarbons (PAHs) have been invoked in fundamental molecular mass growth processes in our galaxy. We provide compelling evidence of the formation of the very first ringed aromatic and building block of PAHs—benzene—via the self-recombination of two resonantly stabilized propargyl (C 3 H 3 ) radicals in dilute environments using isomer-selective synchrotron-based mass spectro
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Dynamin controls neuropeptide secretion by organizing dense-core vesicle fusion sites
Synaptic vesicles (SVs) release neurotransmitters at specialized active zones, but release sites and organizing principles for the other major secretory pathway, neuropeptide/neuromodulator release from dense-core vesicles (DCVs), remain elusive. We identify dynamins, yeast Vps1 orthologs, as DCV fusion site organizers in mammalian neurons. Genetic or pharmacological inactivation of all three dyn
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Coupling of the mid-depth and abyssal components of the global overturning circulation according to a state estimate
Using velocities from a state estimate, Lagrangian analysis maps the global routes of North Atlantic Deep Water (NADW) exiting the Atlantic and reentering the upper branch of the Atlantic Meridional Overturning Circulation (AMOC). Virtual particle trajectories followed for 8100 years highlight an upper route (32%) and a lower route (68%). The latter samples 2 > 37.07 and is further divided into s
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Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis
Inflammation is known to adversely affect adult neurogenesis, wherein the source of inflammation is largely thought to be extraneous to the neurogenic niche. Here, we demonstrate that the adult hippocampal neural progenitors harbor an inflammatory potential that is proactively suppressed by transcription factor 4 ( Tcf4 ). Deletion of Tcf4 in hippocampal nestin -expressing progenitors causes loss
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Optical switching of topological phase in a perovskite polariton lattice
Strong light-matter interaction enriches topological photonics by dressing light with matter, which provides the possibility to realize active nonlinear topological devices with immunity to defects. Topological exciton polaritons—half-light, half-matter quasiparticles with giant optical nonlinearity—represent a unique platform for active topological photonics. Previous demonstrations of exciton p
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Metasurface-based key for computational imaging encryption
Optical metasurfaces can offer high-quality multichannel displays by modulating different degrees of freedom of light, demonstrating great potential in the next generation of optical encryption and anti-counterfeiting. Different from the direct imaging modality of metasurfaces, single-pixel imaging (SPI) as a typical computational imaging technique obtains the object image from a decryption-like
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Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER
The conserved signal recognition particle (SRP) cotranslationally delivers ~30% of the proteome to the eukaryotic endoplasmic reticulum (ER). The molecular mechanism by which eukaryotic SRP transitions from cargo recognition in the cytosol to protein translocation at the ER is not understood. Here, structural, biochemical, and single-molecule studies show that this transition requires multiple se
1d
Soft anharmonic phonons and ultralow thermal conductivity in Mg3(Sb, Bi)2 thermoelectrics
The candidate thermoelectric compounds Mg 3 Sb 2 and Mg 3 Bi 2 show excellent performance near ambient temperature, enabled by an anomalously low lattice thermal conductivity ( l ) comparable to those of much heavier PbTe or Bi 2 Te 3 . Contrary to common mass-trend expectations, replacing Mg with heavier Ca or Yb yields a threefold increase in l in CaMg 2 Sb 2 and YbMg 2 Bi 2 . Here, we report a
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A highly stable lithium metal anode enabled by Ag nanoparticle-embedded nitrogen-doped carbon macroporous fibers
Lithium metal has been considered as an ideal anode candidate for future high energy density lithium batteries. Herein, we develop a three-dimensional (3D) hybrid host consisting of Ag nanoparticle–embedded nitrogen-doped carbon macroporous fibers (denoted as Ag@CMFs) with selective nucleation and targeted deposition of Li. The 3D macroporous framework can inhibit the formation of dendritic Li by
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Cryo-electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex
The antidiuretic hormone arginine-vasopressin (AVP) forms a signaling complex with the V2 receptor (V2R) and the G s protein, promoting kidney water reabsorption. Molecular mechanisms underlying activation of this critical G protein–coupled receptor (GPCR) signaling system are still unknown. To fill this gap of knowledge, we report here the cryo–electron microscopy structure of the AVP-V2R-G s co
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A flexible multiplexed immunosensor for point-of-care in situ wound monitoring
Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the w
1d
Cog psychology vs cog science
Hi guys! I'm a psychology student looking for potential masters and I was just wondering what exactly is a difference between cognitive psychology and cognitive science? They do seem to measure the same thing. Thanks 🙂 submitted by /u/SoggyFunction7025 [link] [comments]
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A short questionnaire that can track emotional changes before and after intervention (visual stimuli)
Hello! I am looking for a short questionnaire for my study that can track emotional changes before and after intervention (visual emotional stimuli). Would you have any suggestion? Especially, I am looking for "The Profile of Mood State" (POMS) but it should be validated in general population, healthy adults, and publicly open to use. Do you know any? submitted by /u/helloiambrain [link] [comment
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Solid-state batteries line up for better performance
Solid-state batteries pack a lot of energy into a small space, but their electrodes are not good at keeping in touch with their electrolytes. Liquid electrolytes reach every nook and cranny of an electrode to spark energy, but liquids take up space without storing energy and fail over time. Researchers are now putting solid electrolytes in touch with electrodes made of strategically arranged mater
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Survival of migrating juvenile salmon depends on stream flow thresholds
Juvenile salmon migrating to the sea in the Sacramento River face a gauntlet of hazards in an environment drastically modified by humans, especially with respect to historical patterns of stream flow. Now fisheries scientists have identified key thresholds in the relationship between stream flow and salmon survival that can serve as actionable targets for managing water resources in the Sacramento
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New tool factors effects of fossil-fuel emissions on ocean research
A newly developed tool will allow scientists to better gauge how centuries of fossil fuel emissions could be skewing the data they collect from marine environments. Researchers at the University of Alaska Fairbanks led the effort, which created a way for marine scientists to factor into their results the vast amounts of anthropogenic carbon dioxide that are being absorbed by oceans.
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Protein architecture of the yeast genome
Nature, Published online: 21 May 2021; doi:10.1038/d41586-021-01118-4 Use of chromatin immunoprecipitation with exonuclease treatment (ChIP–exo) determines the positional organization of hundreds of chromosomal proteins throughout the Saccharomyces cerevisiae genome. The resulting ultra-high-resolution map provides insight into the regulation of genes, enhancers, replication origins, centromeres,
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Balancing carbon storage under elevated CO2
Nature, Published online: 21 May 2021; doi:10.1038/d41586-021-01117-5 A global synthesis of experiments reveals that increases in plant biomass under conditions of elevated CO2 mean that plants need to mine the soil for nutrients, which decreases soil's ability to store carbon. In forests, elevated CO2 generally seems to greatly increase plant biomass, but not soil carbon. In grasslands, by contr
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An array of four germanium qubits
Nature, Published online: 21 May 2021; doi:10.1038/d41586-021-01116-6 A four-qubit quantum processor based on germanium hole spin quantum dots is presented. Universal quantum logic is demonstrated on qubits that are positioned in a two-by-two grid, revealing that spin qubits can be coupled in two dimensions.
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Big Chief vs. Kye Kelley | Street Outlaws: America's List
Stream Full Episodes of Street Outlaws: America's List: discovery+ ► https://www.discoveryplus.com/show/street-outlaws-americas-list Discovery ► https://go.discovery.com/tv-shows/street-outlaws-americas-list/ Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https
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Därför kan bisfenol F i plastsaker orsaka lägre IQ
Bisfenol F som finns i plastprodukter kan framkalla förändringar i en gen som är viktig för neurologisk utveckling,. Det förklarar varför barn till kvinnor som exponerats för kemikalien bisfenol F under tidig graviditet löper risk att utveckla en sämre kognitiv förmåga. Forskarna bakom upptäckten har tidigare visat att exponering av bisfenol F, som förkortas BPF, i moderlivet kan kopplas till läg
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A new form of carbon opens door to nanosized wires
A new allotrope of carbon has been produced. Like graphene, it is only one atom thick, but unlike graphene it behaves like a metal even at small scales, ideal for nanosized wires. This result is exciting for engineers trying to develop new carbon-based electronics and the new method demonstrates a novel way to produce other theoretically-designed but not-yet-created forms of nanoscale carbon mater
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Legitimation strategies for coal exits in Germany and Canada
Ending our dependence on coal is essential for effective climate protection. Nevertheless, efforts to phase out coal trigger anxiety and resistance, particularly in mining regions. The governments of both Canada and Germany have involved various stakeholders to develop recommendations aimed at delivering just transitions and guiding structural change. In a new study, researchers at the Institute f
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Telling up from down: How marine flatworms learn to sense gravity
All living organisms are equipped with sensory organs to detect changes in their surrounding environment. It may not immediately strike us as obvious but, similar to how we can sense heat, cold, light, and darkness, we are also extremely adept at sensing gravity. In our case, it is our inner ear that does this job, helping us maintain balance, posture, and orientation in space. But, what about oth
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Researchers develop advanced model to improve safety of next-generation reactors
When one of the largest modern earthquakes struck Japan on March 11, 2011, the nuclear reactors at Fukushima-Daiichi automatically shut down, as designed. The emergency systems, which would have helped maintain the necessary cooling of the core, were destroyed by the subsequent tsunami. Because the reactor could no longer cool itself, the core overheated, resulting in a severe nuclear meltdown, th
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CVIA has just published a new issue, Volume 5 Issue 4
Beijing, 19 May 2021: Cardiovascular Innovations and Applications (CVIA) has just published a new issue, Volume 5 Issue 4. This issue brings together important research from leading researchers and includes two important new review papers of major interest to cardiologists.Progress in the Study of the Left Atrial Function Index in Cardiovascular Disease: A Literature Review and Better Than You Thi
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Making the gray cells happy
Depressive disorders are among the most frequent illnesses worldwide. The causes are complex and to date only partially understood. The trace element lithium appears to play a role. Using neutrons of the research neutron source at the Technical University of Munich (TUM), a research team has now proved that the distribution of lithium in the brains of depressive people is different from the distri
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More people shop according to brand values
A survey on brand values finds that the majority of Americans, 54%, now say companies should take a stand on issues, even if they disagree with it. The findings, available online in a white paper, come from a survey conducted in January 2021 by the brand measurement company Vrity. The researchers wanted to study generational differences in consumer values and how the COVID-19 pandemic has affecte
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Pivotal results from Trinity clinical trial for the chronic condition atopic dermatitis
Trinity College Dublin and St James's Hospital, Dublin clinical trials reported efficacy and safety results of upadacitinib compared with placebo for the treatment of moderate-to-severe atopic dermatitis in adults and adolescents. This pivotal Global Phase 3 study involved 1,600 patients and took place over a two-year period. Results show the drug to so far be the most effective treatment for atop
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NIST, collaborators develop new method to better study microscopic plastics in the ocean
If you've been to your local beach, you may have noticed the wind tossing around litter such as a plastic straw. Many of these plastics break down into microscopic sizes, making it hard for scientists to quantify and measure them. In a multiorganizational effort led by the National Institute of Standards and Technology (NIST) and the European Commission's Joint Research Centre (JRC), researchers h
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Finding the first flower from Northwest China
A new eudicot, Gansufructus saligna gen. et sp. nov. is reported from the late Early Cretaceous of Gansu, Northwest China, based on numerous exceptionally well-preserved axes with leaves and infructescences. It is the earliest and unique record of early angiosperms in Northwest China. Morphological studies indicated that Gansufructus saligna is a terrestrial herb growing in lowland humid areas. Th
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China's PM2.5 pathways under carbon neutrality goals
Zhang, Q and colleagues assessed China's PM2.5 air quality pathways during 2015-2060 in the context of carbon neutrality goals. Their findings suggest that reducing PM2.5 exposure of the majority Chinese population to the WHO guideline (10ug/m3 for annual mean) will require ambitious low-carbon transition in energy system, highlighting the critical role of carbon neutrality goals in long-term air
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Integrated cyber attack analysis platform "NIRVANA Kai" supports IPv6
The Cybersecurity Laboratory of the National Institute of Information and Communications Technology (NICT) has enhanced its cyber attack integrated analysis platform "NIRVANA Kai" to support the Internet Protocol version 6 (IPv6), the successor to IPv4. NIRVANA Kai has succeeded in real-time visualization of packets flowing in the vast address space of IPv6 for the first time in the world. It is e
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'Gecko gripper' could clean up space junk
A "gecko gripper" could clean up the millions of pieces of space junk floating in space. The gecko gripper is a mechanical attachment for a robot that can grasp surfaces using adhesive inspired by the pads of a gecko's feet. The technology could be especially useful in space because the gecko adhesive doesn't require any force to attach to a surface. "The texture of it is too fine to see, but if
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Tardigrades Shot Out of a Gun to Test Origin-of-Life Theory
Tardigrades are legendarily tough. The microscopic animals, also colloquially referred to as "water bears," can survive extremes of pressure, radiation, temperature, and dehydration. They're capable of surviving in environments where these extremes are presented simultaneously, including outer space. This makes them useful for testing certain theories regarding the origin of life on Earth. One of
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In utero exposure to tiny air pollution particles is linked to asthma in preschoolers
Women who were highly exposed to ultra-fine particles in air pollution during their pregnancy were more likely to have children who developed asthma, according to a study published in the American Journal of Respiratory and Critical Care Medicine in May. This is the first time asthma has been linked with prenatal exposure to this type of air pollution, which is named for its tiny size and which is
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Device for detection of signs of sudden cardiac death developed at TPU
Scientists of Tomsk Polytechnic University have developed a nanosensor-based hardware and software complex for measurement of cardiac micropotential energies without filtering and averaging-out cardiac cycles in real time. The device allows registering early abnormalities in the function of cardiac muscle cells, which otherwise can be recorded only during open-heart surgery or by inserting an elec
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8 ways to approach the return to school
Returning to school in person after a year's worth of pandemic-induced absence is sure to spark a range of challenges and stresses for students, teachers, and parents. Leaving the safety of Zoom and being among masked-up peers and others, along with the stimuli that accompanies being in public for the first time in a year in a classroom setting, will affect everyone differently. Jennifer Ruef and
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Same nerve cell — Different influence on food intake
The nerve cells, also called neurons, in our brain control all the basic processes of our body. For this reason, there are different types of neurons distributed over specific regions of the brain. Researchers have now developed an approach that allows them to show that neurons that are supposedly the same are actually very different: they not only sense different hormones for the body's energy st
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Myndigheder advarer om farligt UV-lys til corona-bekæmpelse
PLUS. Sikkerhedsstyrelsen får flere og flere anmeldelser af ulovlige UVC-lys til private, der kaster stråler direkte ud i rummet eller overskrider grænseværdier for den ultraviolette stråling. Tidligere har både SSI og professor kaldt UVC-lys for unødvendigt uden for sundhedssektoren.
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Nye analyser fra Lif: Ulighed i kræftbehandling koster 3.500 liv årligt
Lægemiddelindustriforeningen står bag to nye analyser, som kortlægger henholdsvis ulighed i opsporing og diagnostik af kræft og ulighed i behandling af kræft. Tilsammen konkluderer analyserne, at hvis alle kræftpatienter havde samme muligheder som de bedst stillede, kunne man redde eller forlænge livet for 3.550 patienter om året.
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Stunning New Model Simulates Star Formation in Highest-Ever Resolution
Star formation is the first step on the cosmological road to life as we know it, but understanding the process of star formation is incredibly difficult. The process takes millions of years, so we can only learn so much from scouring the heavens, and simulating it requires hugely complex replicas. That's where STARFORGE comes in handy. This new simulation is 100 times larger than previous star fo
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Get Maximum Comfort And Minimal Noise With ComfoBuds Pro
Noise control is the next great frontier in human comfort, to the point where we're building noise cancellation into building materials . But if you want your noise cancellation to follow you every day, the ComfoBuds Pro Headphones make it easy to control where and when you tune in to the world, using a mix of technologies called QuietMax. The bedrock QuietMax builds on is active noise canceling,
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PODCAST: Hvor mange affaldsspande skal vi have i fremtiden?
Er du træt af at sortere dit husholdningsaffald i ti fraktioner, vil det måske opmuntre dig, at robotter i dag kan gøre det lige så godt. Til gengæld er der ingen udsigt til, at robotter og automation gør den manuelle arbejdskraft overflødig foreløbig, mener amerikansk økonomisk historiker.
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Daily briefing: A new coronavirus might be from dogs
Nature, Published online: 20 May 2021; doi:10.1038/d41586-021-01385-1 Dogs might have given eight people a totally new coronavirus in 2018. Plus, the first images of Mars's surface from the Zhurong rover and how mix-and-match COVID vaccines trigger a potent immune response.
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Strong spin-orbit coupling inducing Autler-Townes effect in lead halide perovskite nanocrystals
Nature Communications, Published online: 21 May 2021; doi:10.1038/s41467-021-23291-w Here, Yumoto et al. demonstrate that for a halide perovskite with large spin-orbit splitting the optical Stark effect can give way to a three level Autler-Townes effect in the near-infrared region. The multiband nature of the effect potentially allows for further optical control over quantum states.
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Catalytic asymmetric Nakamura reaction by gold(I)/chiral N,Nʹ-dioxide-indium(III) or nickel(II) synergistic catalysis
Nature Communications, Published online: 21 May 2021; doi:10.1038/s41467-021-23105-z Although enols and enolates addition to unactivated alkynes is used for carbon-carbon bond modification a catalytic asymmetric alkyne with 1,3-dicarbonyl compound has been elusive. Here, the authors achieve this using the synergistic activation of chiral N,N′-dioxide-indium(III) or nickel(II) Lewis acid and achir
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Regioselective activation of benzocyclobutenones and dienamides lead to anti-Bredt bridged-ring systems by a [4+4] cycloaddition
Nature Communications, Published online: 21 May 2021; doi:10.1038/s41467-021-23344-0 Bridgehead carbon benzofused-bridged ring systems have previously not been accessible via synthetic approaches. Here, the authors report a formal type-II [4 + 4] annulation approach that provides fully sp2-carbon embedded anti-Bredt bicyclo[5.3.1] skeletons through the Rh-catalyzed C1–C8 activation of benzocyclob
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Permutation-based identification of important biomarkers for complex diseases via machine learning models
Nature Communications, Published online: 21 May 2021; doi:10.1038/s41467-021-22756-2 Study of human disease remains challenging due to convoluted disease etiologies and complex molecular mechanisms at genetic, genomic, and proteomic levels. Here, the authors propose a computationally efficient Permutation-based Feature Importance Test to assist interpretation and selection of individual features
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Mattertronics for programmable manipulation and multiplex storage of pseudo-diamagnetic holes and label-free cells
Nature Communications, Published online: 21 May 2021; doi:10.1038/s41467-021-23251-4 Here, the authors present a pseudo-diamagnetophoresis mattertronic approach for programmable manipulation of label-free cells. Immersed in biocompatible ferrofluids, single cells are moved along linear negative micromagnetic patterns, switched at eclipse diode patterns and stored in potential wells.
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Robot-assisted, source-camera-coupled multi-view broadband imagers for ubiquitous sensing platform
Nature Communications, Published online: 21 May 2021; doi:10.1038/s41467-021-23089-w The use of imager devices to supplement broadband photo-monitoring technology has enabled multi-functional sensing capability relevant to internet of things-related applications. Here, the authors report a robotassisted imager-implanted broadband photo-monitoring sensing platform.
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Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology
Nature Communications, Published online: 21 May 2021; doi:10.1038/s41467-021-23327-1 Members of the CHD chromatin remodeler family are implicated in human pathologies, however CHD6 remained poorly studied. Here, the authors show that CHD6 binds to and regulates autophagy and stress response genes across cell types. They identify a clinical mutation that affects its ability to recruit cofactors, l
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New nondestructive broadband imager is the next step towards advanced technology
Scientists at Tokyo Institute of Technology (Tokyo Tech) have designed a versatile sensing platform with a compact source-camera module that enables 3D feature extraction of curved objects at multiple frequencies ranging from terahertz to infrared light. In their paper, they demonstrate rapid, omnidirectional photo-monitoring performance after integrating their platform to a robot-assisted movable
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Barn blev bättre på matte efter kognitiv träning
När barn fick öva sina kognitiva förmågor blev de bättre på matematik. Deras mattekunskaper påverkades olika mycket beroende på vilka övningar de fick göra. Barn som tränade visuellt arbetsminne och problemlösning förbättrade sina mattekunskaper mer än barn som fokuserade på rotationsövningar. Det visar en stor studie av forskare vid Karolinska Institutet. Resultatet tyder på att kognitiv träning
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States laws limit local control over guns, favor gun rights
The majority of U.S. states have passed laws preserving state authority over firearms policies—and preventing local communities from passing their own—but at the same time have refrained from enacting statewide gun-control policies, according to a new study by researchers at NYU School of Global Public Health.
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Study on intermittency in gang membership underscores value of preventing youth from rejoining gangs
Research has shown that joining a gang is associated with increased criminal behavior. A new study examined whether the intermittent nature of gang membership affects offending. Researchers sought to determine whether the association with increased offending was a consistent attribute or, since people enter and exit and re-enter gangs, whether the intermittent nature of membership affected members
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Podd: Tvångssteriliseringar, genetiken och etiken
Ny genteknik ger hopp om nya behandlingar mot svåra sjukdomar, men väcker etiska frågor. Kan vi sluta bekymra oss om problem i arbetsmiljön om vi lyckas justera gener som skyddar oss från toxiska ämnen? Vi blickar tillbaka till när kunskapen om hur egenskaper ärvs vidare växte fram. Hur tänkte man då, finns det likheter idag och vad kan vi lära oss?
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Schneider Shorts 21.05.2021: Anal Science
Schneider Shorts of 21 May 2021 with a whistleblower's letter, some proud trachea transplanters, racism in sports and sperm, an Israeli surgeon's first-time retraction, a Brazilian angel of death, Germans embracing Vitamin D, ivermectin and illegal Stöcker vaccines, Indians embracing cow manure, and mice sodomised with a toothbrush to invent a cure for COVID-19.
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Will we eventually see a resource-based economy like the ones advocated by the Venus Project and the Zeitgeist Movement?
With jobs increasingly being replaced overtime by automation and the wealth gap between rich and poor widening overtime are more and more people beginning to question the monetary system we are living in right now? Is the concept of RBE increasing in popularity? Are movements like the Venus Project and the Zeitgeist Movement gaining traction? Could the upcoming AI revolution help propel the conce
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Energy and climate journalists from Canary Media and David Roberts are here to answer your questions on the energy transition!
Hi Reddit! We're Canary Media , a team of journalists that has been covering renewable energy, decarbonization, and the transition away from fossil fuels, long before it was mainstream news. Many of our journalists spent years writing for Greentech Media. You may be familiar with Canary Media Editor-at-Large David Roberts, who was previously at Vox and Grist but now runs his own newsletter, Volts
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Tampons, sanitary napkins could diagnose yeast infections with color-changing threads
The yeast Candida albicans can cause itchy, painful urinary tract and vaginal yeast infections. For women in low-resource settings who lack access to healthcare facilities, these infections create substantial social and economic burdens. Now, researchers have developed color-changing threads that turn bright pink in the presence of C. albicans. When embedded in tampons or sanitary napkins, they co
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Envisioning safer cities with AI
Researchers developed a suite of AI tools that can automatically identify characteristics of every buildings in a city and compute the risks they would face during a natural hazard event. The team tested the tools with simulated earthquakes in San Francisco; and hurricanes in Lake Charles, Louisiana, the Texas coast, and Atlantic City, New Jersey. The simulations generated realistic spatial distri
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Cholesterol levels sustainably lowered using base editing
Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team has succeeded in sustainably lowering high LDL cholesterol levels in the blood of mice and macaques. This opens up the possibility of curing patients with inherited metabolic liver diseases.
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Magnetically propelled cilia power climbing soft robots and microfluidic pumps
The rhythmic motions of hair-like cilia move liquids around cells or propel the cells themselves. In nature, cilia flap independently, and mimicking these movements with artificial materials requires complex mechanisms. Now, researchers have made artificial cilia that move in a wave-like fashion when a rotating magnetic field is applied, making them suitable for versatile, climbing soft robots and
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Mangroves offer coral reefs a refuge from stress
More species of corals live in mangrove forests than in nearby shallow reefs, finds a new analysis of how environmental factors influence the growth and health of corals. Researchers say this is a testament to coral adaptability, and the importance of ecological partnerships—such as between corals and mangroves—for the resilience of these ecosystems in the wake of human-made environmental turmoil
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Small uveal melanomas 'not always harmless'
A new article from ocular researchers demonstrates that small uveal (intraocular) melanomas are not always harmless, as the current paradigm suggests. Instead, a reasonable proportion of them have molecular genetic alterations, which categorizes them as highly metastatic tumors. The article recommends that they should not be observed but rather treated immediately, to improve patients' chances of
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Rising energy demand for cooling
Climate-related temperature rises will further increase the cooling demand of buildings. A projection by researchers based on data from the NEST building and future climate scenarios for Switzerland shows that this increase in energy demand for cooling is likely to be substantial and could have a strong impact on our future – electrified – energy system.
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Crocodiles can't thrive when the water turns salty
Increased salinity in water that American crocodiles navigate influences their health, breeding behavior, and ultimately, survival, a new study shows. Researchers mapped out the status of their population over the last 40 years in response to changes in the Florida Everglades. Considered a key wildlife indicator, the health of the American crocodile will continue to tell us whether water restorat
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Save Over 60% On A Babbel Lifetime Subscription In This Flash Sale
Any language is an organism that evolves over time, and that can make learning a new one a tricky thing. For more than a decade, Babbel has been immersing its users in language to learn what they use from native speakers. That's made it the top-selling language app, and during this flash sale, you can get lifetime access to all Babbel's languages for just $179 during our flash sale . Babbel works
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Saving the eastern monarch butterfly
Researchers are playing a key role in guiding conservation efforts to protect a declining butterfly population. The eastern monarch butterfly, an important pollinating species known for its distinct yellow-orange and black color, is diminishing due to the loss of the milkweed plant–its primary food source.
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AI predicts lung cancer risk
An artificial intelligence program accurately predicts the risk that lung nodules detected on screening CT will become cancerous, according to a new study.
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Best CBD Dog Treats: 15 Best Products
What if you could give your dog a treat that not only tastes good, but supports his overall health and wellness? CBD has taken the pet industry by storm, and today, there are hundreds of CBD-infused dog treats on the market. Whether your pup prefers soft treats or crunchy bones, you're sure to find CBD treats that will get your dog's tail wagging. So why CBD treats? Over the last few years, the p
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New type of particle accelerator: Electrons riding a double wave
An international research group has now made significant progress in the further development of compact plasma accelerators, considered a promising technology for the future: With two complementary experiments, the team was able to combine two different plasma technologies for the first time and build a novel hybrid accelerator. The concept could advance accelerator development and, in the long te
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Young orangutans have sex-specific role models
Social learning in orangutans is shaped by their sex. Young males learn their foraging skills from immigrant individuals, while young females get their skills by observing their mothers and other residents in the area. These different sets of ecological knowledge help secure their survival.
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Thinking about externals
Hi all – I'm looking for studies pertaining to how external stimuli (visuals, sound, etc) impact conscious internal thought processes in the moment. As an example: you may watch a movie mindlessly, as most do. But you could also be Thinking about what you're seeing and hearing, and recreating the scenery in your mind as you watch the movie. I'm just looking for research on how the mind uses curre
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Magnetoreception – a Quantum Sixth Sense
Imagine you are dropped off hundreds of miles away from your home, deep in some unknown forest. Would you be able to find your way home using only your five basic senses – sight, smell, sound, taste, and touch? If you're anything like me, you may struggle to navigate around your own city without help […]
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The impact of real-time feedback in employee reviews
To deliver real-time feedback to support employee development and rapid innovation, many companies are replacing formal, review-based performance management with systems that enable frequent and continuous employee evaluation. New research in the INFORMS journal Information Systems Research examines the role of these applications to understand the effects on employee performance appraisals.
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Nonparametric coalescent inference of mutation spectrum history and demography [Statistics]
As populations boom and bust, the accumulation of genetic diversity is modulated, encoding histories of living populations in present-day variation. Many methods exist to decode these histories, and all must make strong model assumptions. It is typical to assume that mutations accumulate uniformly across the genome at a constant rate…
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Microevolution in the pansecondary metabolome of Aspergillus flavus and its potential macroevolutionary implications for filamentous fungi [Microbiology]
Fungi produce a wealth of pharmacologically bioactive secondary metabolites (SMs) from biosynthetic gene clusters (BGCs). It is common practice for drug discovery efforts to treat species' secondary metabolomes as being well represented by a single or a small number of representative genomes. However, this approach misses the possibility that intraspecific…
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Evolutionary design of magnetic soft continuum robots [Engineering]
Worldwide cardiovascular diseases such as stroke and heart disease are the leading cause of mortality. While guidewire/catheter-based minimally invasive surgery is used to treat a variety of cardiovascular disorders, existing passive guidewires and catheters suffer from several limitations such as low steerability and vessel access through complex geometry of vasculatures…
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A stress-responsive miRNA regulates BMP signaling to maintain tissue homeostasis [Cell Biology]
Adult organisms must sense and adapt to environmental fluctuations. In high-turnover tissues such as the intestine, these adaptive responses require rapid changes in gene expression that, in turn, likely involve posttranscriptional gene control. However, intestinal-tissue–specific microRNA (miRNA)-mediated regulatory pathways remain unexplored. Here, we report the role of an intestinal-specific mi
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Pharmacological inhibition of MDA-9/Syntenin blocks breast cancer metastasis through suppression of IL-1{beta} [Medical Sciences]
Melanoma differentiation associated gene-9 (MDA-9), Syntenin-1, or syndecan binding protein is a differentially regulated prometastatic gene with elevated expression in advanced stages of melanoma. MDA-9/Syntenin expression positively associates with advanced disease stage in multiple histologically distinct cancers and negatively correlates with patient survival and response to chemotherapy. MDA-
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A new form of carbon
A new allotrope of carbon has been produced by a European team. Like graphene, it is only one atom thick, but unlike graphene it behaves like a metal even at small scales, ideal for nanosized wires. This result is exciting for engineers trying to develop new carbon-based electronics and the new method demonstrates a novel way to produce other theoretically-designed but not-yet-created forms of nan
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New research maps COVID-19 dispersal dynamics in New York's first wave of epidemic
During the first phase of the COVID-19 epidemic, New York City experienced high prevalence compared to other U.S. cities, yet little is known about the circulation of SARS-CoV-2 within and among its boroughs. A study published in PLOS Pathogens by Simon Dellicour at Université Libre de Bruxelles, Belgium, Ralf Duerr and Adriana Heguy at New York University, USA, and colleagues describe the dispers
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Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling
Obesity is a global epidemic that causes morbidity and impaired quality of life. The melanocortin receptor 4 (MC4R) is at the crux of appetite, energy homeostasis, and body-weight control in the central nervous system and is a prime target for anti-obesity drugs. Here, we present the cryo–electron microscopy (cryo-EM) structure of the human MC4R-G s signaling complex bound to the agonist setmelan
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Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil
Cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Manaus, Brazil, resurged in late 2020 despite previously high levels of infection. Genome sequencing of viruses sampled in Manaus between November 2020 and January 2021 revealed the emergence and circulation of a novel SARS-CoV-2 variant of concern. Lineage P.1 acquired 17 mutations, including a trio in the spike p
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Reversible ketone hydrogenation and dehydrogenation for aqueous organic redox flow batteries
Aqueous redox flow batteries with organic active materials offer an environmentally benign, tunable, and safe route to large-scale energy storage. Development has been limited to a small palette of organics that are aqueous soluble and tend to display the necessary redox reversibility within the water stability window. We show how molecular engineering of fluorenone enables the alcohol electro-ox
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Imaging translation dynamics in live embryos reveals spatial heterogeneities
Much is known about the factors involved in the translation of messenger RNA (mRNA) into protein; however, this multistep process has not been imaged in living multicellular organisms. Here, we deploy the SunTag method to visualize and quantify the timing, location, and kinetics of the translation of single mRNAs in living Drosophila embryos. By focusing on the translation of the conserved major
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Observation of superfluidity in a strongly correlated two-dimensional Fermi gas
Understanding how strongly correlated two-dimensional (2D) systems can give rise to unconventional superconductivity with high critical temperatures is one of the major unsolved problems in condensed matter physics. Ultracold 2D Fermi gases have emerged as clean and controllable model systems to study the interplay of strong correlations and reduced dimensionality, but direct evidence of superflu
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Photocatalytic C-H activation and the subtle role of chlorine radical complexation in reactivity
The functionalization of methane, ethane, and other alkanes derived from fossil fuels is a central goal in the chemical enterprise. Recently, a photocatalytic system comprising [Ce IV Cl 5 (OR)] 2– [Ce IV , cerium(IV); OR, –OCH 3 or –OCCl 2 CH 3 ] was disclosed. The system was reportedly capable of alkane activation by alkoxy radicals (RO•) formed by Ce IV –OR bond photolysis. In this work, we pr
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Experience replay is associated with efficient nonlocal learning
To make effective decisions, people need to consider the relationship between actions and outcomes. These are often separated by time and space. The neural mechanisms by which disjoint actions and outcomes are linked remain unknown. One promising hypothesis involves neural replay of nonlocal experience. Using a task that segregates direct from indirect value learning, combined with magnetoencepha
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Study finds gender pay gap in large government agency
The study sought to describe and explain gender pay differences in the U.S. Department of Health and Human Services between 2010 and 2018. HHS comprises a quarter of the country's governmental public health workers, with over 80,000 employees.
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Rare 4000 year comets can cause meteor showers on Earth
Comets that circle the Sun in very elongated orbits spread their debris so thin along their orbit or eject it out of the solar system altogether that their meteor showers are hard to detect. From a new meteor shower survey published in the journal Icarus, researchers now report that they can detect showers from the debris in the path of comets that pass close to Earth orbit and are known to return
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Ford Unleashes 2022 F-150 Lightning Full-Size Electric Pickup Truck
2022 Ford F-150 Lightning Lariat. Pre-production model with available features shown. Available starting spring 2022. Always consult the owner's manual before off-road driving, know your terrain and trail difficulty and use appropriate safety gear. It's hard to think of something more Earth-shaking for the auto industry than the introduction of the first electric Ford F-Series, the best-selling U
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Opening up possibilities with open-top optofluidic device
Microfluidic technologies have seen great advances over the past few decades in addressing applications such as biochemical analysis, pharmaceutical development, and point-of-care diagnostics. Miniaturization of biochemical operations performed on lab-on-a-chip microfluidic platforms benefit from reduced sample, reagent, and waste volumes, as well as increased parallelization and automation. This
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Researchers collaborate across disciplines to characterize the economics and value of pollination
The University of Maryland (UMD) co-published a new review paper in the Annual Review of Resource Economics to examine pollinators from both an economic and ecological perspective, providing much needed insight into the complexities of valuing pollination. Pollinators are not only a critical component of a healthy ecosystem, but they are also necessary to produce certain foods and boost crop yield
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Aphids may spit in a plant up to 20 times before they start eating it
Identifying the genetic code for disease resistance in plants is normally a tricky thing. A single gene can usually only offer protection against a specific disease or parasite. But this time it's different. Researchers at Wageningen University & Research, Umeå University and Keygene have discovered that a resistance gene in thale cress (Arabidopsis thaliana) against the green peach aphid, also re
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Worn tires could be reused in new asphalt roadways
Swiss drivers wear out countless tires. Instead of incinerating them, they could be reused locally: The asphalt of various countries has long contained rubber from used tires. Empa and its partners from industry are adopting this idea for potential applications in Switzerland.
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A closer look at the creation of a metamorphic sole
When two of Earth's tectonic plates collide, the heavier plate is forced underneath and back into the mantle in a process called subduction. During the early stages of newly initiated subduction zones, the uppermost part of the downward traveling plate can detach and accrete to the base of the overriding (upper) plate. Later, these slices can be exposed at Earth's surface and are known as metamorp
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Compound may prevent arrhythmia side effect
New research identifies a compound that may prevent a dangerous and sometimes deadly arrhythmia called Torsades de Pointes. Many drugs that are effective against cancer, infections, and other diseases, can induce a lengthening of the heart's electrical event, or action potential, as an adverse side effect . This can render these drugs unsafe or too risky for patients. According to the American He
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The when and why of foehn warming in northwestern Japan
Warm, dry wind events blowing down from mountain slopes, called foehns, are a meteorological phenomenon typically associated with the European Alps or the Rocky Mountains of North America. However, in recent decades, foehn winds in Japan have caused record-breaking hazardous warm weather events, bringing renewed interest in the behavior of these winds in this part of the world.
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Weight cycling linked to increased sleep problems in women
Women with a history of weight cycling – losing and regaining 10 pounds or more, even once – have increased rates of insomnia and other sleep problems, reports a study in the Journal of Cardiovascular Nursing, official journal of the Preventive Cardiovascular Nurses Association. The journal is published in the Lippincott portfolio by Wolters Kluwer.
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UMD collaborates across disciplines to characterize the economics and value of pollination
The University of Maryland (UMD) co-published a paper to examine pollinators from both an economic and ecological perspective, providing much needed insight into the complexities of valuing pollination. This recent collaboration highlights the importance of characterizing the economic value of pollination services, including that of managed and wild pollinators, both for the sustainability of hone
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Sheltering people with COVID-19 experiencing homelessness curbs spread
A new study provides public health planning authorities with a method of calculating the number of COVID-19 isolation beds they would need for people experiencing homelessness based on level of infection in the city. The research holds promise for controlling spread of the virus – or future infectious diseases – in a population that is highly vulnerable and less likely than many others to access h
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Immune cells promote proinflammatory fatty liver disease
A particular type of dendritic cell is responsible for the tissue damage that occurs in non-alcoholic steatohepatits (NASH) in mice and humans. The dendritic cells cause aggressive, proinflammatory behavior in T cells, as now discovered by researchers from the German Cancer Research Center (DKFZ) in collaboration with colleagues from Israeli research institutes. Blocking these dendritic cells alle
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Molecule enlists patient's immune system to combat HIV
Antiretroviral therapy, the common approach in the treatment of HIV, halts replication of the virus and has saved the lives of millions of people. However, for patients the drug cocktail becomes a lifetime necessity because they continue to harbor latent HIV in a small number of immune system cells. In the absence of treatment, HIV can again replicate and rebound into full blown AIDs.
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Condensing by turning toward the crowd
Like water vapor on the bathroom mirror, gas molecules come together and condense into liquid droplets due to the attractive forces between them. In a study published in Nature Physics, researchers have discovered that active particles can condense by turning and moving toward crowded areas.
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Cardioids — heartbeat, heartbreak and recovery in a dish
Self-organizing heart organoids developed at IMBA — Institute of Molecular Biotechnology of the Austrian Academy of Sciences — are also effective injury- and in vitro congenital disease models. These "cardioids" may revolutionize research into cardiovascular disorders and malformations of the heart. The results are published in the journal Cell.
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Colorectal cancer screening past age 75 lowers cancer death risk for most
Colorectal cancer screening is now recommended for all adults 45 and older with normal risk, but there is a lack of agreement on whether screening beyond age 75 is beneficial. This study of 56,374 older participants in two large, long-term health cohorts is the first to show that screening can significantly reduce risk for colorectal cancer and colorectal cancer-related death in otherwise healthy
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A brand new cocktail to fight HIV
Researchers at the University of Montreal Hospital Research Centre (CRCHUM) and Yale University have succeeded in reducing the size of the HIV reservoir in humanized mice by using a "molecular can opener" and a combination of antibodies found in the blood of infected individuals.
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Moderate-to-high TV viewing in midlife linked to later cognitive and brain health decline
Television viewing is a type of sedentary behavior that is cognitively passive or does not require much thought.Moderate-to-high amounts of television viewing during midlife are associated with greater declines in cognitive function and lower gray matter volumes in the brain.Higher amounts of midlife television viewing did not seem to impact dementia risk.The amount of time spent watching TV may b
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Gender-affirming hormone therapy may not increase CVD risk for transgender adolescents
Before receiving gender-affirming hormone therapy, transgender adolescents are more likely to have at least one atherosclerotic cardiovascular disease (ASCVD) risk factor compared to cisgender (same gender as at birth) adolescents.After one year of gender-affirming hormone therapy, fewer adolescent transgender females had at least one ASCVD risk factor, and transgender males were more likely to ha
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Adult obesity, inactivity associated with violent crime in Black and Hispanic communities
High violent crime rates in Chicago were associated with high levels of physical inactivity and obesity in adults in Black and Hispanic communities, yet this was not the case in white communities.As the violent crime rate increased, the prevalence of physical inactivity and obesity also increased, even after accounting for family income, grocery store availability, public park spaces and walkabili
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Social isolation and loneliness linked to increased risk of CVD in post-menopausal women
Social isolation and loneliness were each associated with a higher risk for cardiovascular disease in post-menopausal women.The risk of cardiovascular disease events in the women increased 29% when the effect of social isolation and loneliness were combined.Researchers suggest assessing social isolation and loneliness, even with a brief questionnaire, should be incorporated into standard care prac
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Black adults in US who consume ultra-processed foods at greater risk for hypertension
A study of almost 6,000 adults ages 45 and older found that Black adults who ranked within the top 25% of all participants for consumption of ultra-processed food were 55% more likely to have high blood pressure compared to white adults who consumed a similar amount of ultra-processed foods.Men and adults who had less education, lower household income and lower levels of physical activity were the
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US CVD death rate drops overall, county-level data signals ongoing regional disparities
Nationwide, death rates from cardiovascular disease have declined over the past few decades.A new county-by-county analysis reveals that despite the overall improvement, the counties with the lowest and highest death rates have, for the most part, maintained those rankings.The researchers found that societal differences in structural, social and health characteristics continue to impact death rate
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Self-organizing human heart organoids
Biologist Sasha Mendjan at the Austrian Academy of Sciences in Vienna and his team have used human pluripotent stem cells to grow sesame-seed-sized heart models, called cardioids, that spontaneously self-organize to develop a hollow chamber without the need of experimental scaffolds. This advance, which allows for the creation of some of the most realistic heart organoids to date, appears on May 2
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Special issue on the COVID-19 pandemic
The international journal Risk Analysis has published a timely special issue for May 2021, "Global Systemic Risk and Resilience for Novel Coronavirus and COVID-19." Featuring 11 papers written for this issue over the past year, the collection represents a sampling of insights and viewpoints from scholars across risk sciences and resilience analytics to guide decision-making and operations related
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Deep learning enables dual screening for cancer and cardiovascular disease
In research published today in Nature Communications, a team of engineers from Rensselaer Polytechnic Institute and clinicians from Massachusetts General Hospital developed a deep learning algorithm that can help assess a patient's risk of cardiovascular disease with the same low-dose computerized tomography (CT) scan used to screen for lung cancer. This approach paves the way for more efficient,
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How injured nerves stop themselves from healing
Damage to nerve fibers in the central nervous system — brain, spinal cord, or optic nerve — often results in lifelong and severe disabilities, such as paraplegia or blindness. Although we are aware of various reasons why nerves fail to regenerate, their treatment has not yet led to any significant clinical successes. A research team from Ruhr-Universität Bochum (RUB) has made a discovery that co
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Influence of anesthetics of neonatal rat brain
Study lead, Research Associate of the Neurobiology Lab Marat Minlebaev explains, "Our brain is a complex mechanism, and it's important to understand how it works. If we understand how our brain functions, we can put forth new treatment methodologies or prevent pathologies, both congenital and acquired."
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Surveillance turns up new coronavirus threat to humans
Researchers have discovered a new coronavirus, found in a child with pneumonia in Malaysia in 2018, that appears to have jumped from dog to human. If confirmed as a pathogen, the novel canine-like coronavirus could represent the eighth unique coronavirus known to cause disease in humans. The discovery also suggests coronaviruses are being transmitted from animals to humans more commonly than was p
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Lower nurse-to-patient ratio saves lives
Establishing minimum nurse-to-patient staffing ratios in hospitals can save lives, prevent readmissions, shorten hospital stays, and reduce costs, a new study finds. Researchers evaluated legislation enacted in 2016 in Queensland, Australia as a safety measure that limited the average number of patients per nurse to four, similar to pending legislation in New York and Illinois. "The positive resu
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Experimental drug makes radiation therapy more effective, less damaging
An experimental drug that has shown promise in protecting healthy tissue from collateral damage caused by radiation therapy for cancer also appears to enhance radiation's capacity to kill tumors, a new study led by UT Southwestern scientists shows. The findings, published online in Science Translational Medicine, could provide a much-needed boost to the radiation treatments used against a variety
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New NUS technology completes vital class of industrial reactions five times faster
Researchers from NUS Engineering have developed a new method to increase the rate of an important chemical reaction known as hydrogenation by more than 5 times. Hydrogenation is used in the production of everyday items like plastics, fertilisers, and pharmaceuticals. The NUS team's novel approach is a more direct and effective method that can lead to higher yields for industries and lower environm
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"Det är lite av en guldrush i norr"
Varför satsar LTU på vätgas?– Omställningen till fossilfritt stål kommer på sikt att kräva omkring en miljon ton vätgas per år i norra Sverige. Vätgasen ska produceras, lagras och transporteras och ingå i ett större system som även innefattar elförsörjning. Här krävs forskning för att hela processen ska bli så effektiv som möjligt. Vi kommer också att studera mjuka frågor som social acceptans för
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Electrons riding a double wave
An international research group has now made significant progress in the further development of compact plasma accelerators, considered a promising technology for the future: With two complementary experiments at HZDR and LMU, the team was able to combine two different plasma technologies for the first time and build a novel hybrid accelerator. The concept could advance accelerator development and
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We know the cost of free choice and locality – in physics and not only
Do we have free choice or are our decisions predetermined? Is physical reality local, or does what we do here and now have an immediate influence on events elsewhere? The answers to these questions are sought by physicists in the Bell inequalities. It turns out that free choice and local realism can be skilfully measured and compared. The results obtained reveal surprising relationships of a funda
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Lægeformand bekymret over vaccinetilvalgsordning
Bekendtgørelse om tilvalg af vacciner giver usikkerhed om lægers retssikkerhed, hvis de ordinerer en vaccine fra AstraZeneca eller Johnson & Johnson, og borgeren efterfølgende får alvorlige bivirkninger, mener Lægeforeningens formand Camilla Noelle Rathcke.
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Did a new coronavirus go from dog to human?
Researchers have discovered a new coronavirus, in a child with pneumonia in Malaysia in 2018, that appears to have jumped from dog to human. If confirmed as a pathogen, the novel canine-like coronavirus could represent the eighth unique coronavirus known to cause disease in humans. "How common this virus is, and whether it can be transmitted efficiently from dogs to humans or between humans, nobo
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Immune genetics and previous common cold infections might help protect Japan from COVID-19
By meta-analysis, experimentally determined COVID-19 virus T cell epitopes were compared with sequences of common cold coronaviruses (CCCoVs). Only one CCCoV-matching epitope was repeatedly identified as highly immunogenic, namely the CD8+ T cell epitope VYIGDPAQL ("VYI" peptide) if presented by the MHC class I allele HLA-A*24:02. Approximately 60% of Japanese individuals carry this allele, which
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Challenging the standard model of cancer
In spite of decades of research, cancer remains an enigma. Conventional wisdom holds that cancer is driven by random mutations that create aberrant cells that run amok in the body. In a new paper published this week in the journal BioEssays, Arizona and Australian researchers challenge this model by proposing that cancer is a type of genetic throwback, that progresses via a series of reversions to
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China's Mars Rover Sends Back First Images
Things are changing on Mars, a world once dominated by robots from the United States. Now, Mars is home to an international cadre of robotic explorers with the arrival of China's Zhurong rover. The mission touched down over the weekend, and Zhurong has just beamed back the first images from atop its landing platform. Soon, operators on Earth will set Zhurong loose on the red planet. The Zhurong r
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Space Weather and Moon Landings
As project Artemis proceeds with plans not only to return to the Moon, but to produce the infrastructure for a long term presence, we need to deal with the issue of solar storms. If you haven't seen the series, For All Mankind , I highly recommend it. In one episode they dramatize the effects of a particularly strong solar storm. I don't think the special effects were accurate (the moon dust woul
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Have we entered the Anthropocene – a new epoch in Earth's history?
Human beings have transformed the planet. Over the last century we've disrupted the climate and impacted entire ecosystems. This has led some to propose that we've entered another chapter in Earth's history called the Anthropocene. Anand Jagatia speaks to Dr Simon Turner from the Anthropocene Working Group, given the task of gathering evidence on whether it will become an official unit of geologic
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Övervikt skyddar mot död vid svår bakteriell infektion
Övervikt och fetma utgör riskfaktorer vid många sjukdomar, men kan vara ett skydd för patienter som vårdas på sjukhus för svåra bakteriella infektioner. Det visar en studie från forskare vid Sahlgrenska Akademin. Studien bygger på observationer av samtliga vuxna patienter som vårdades för misstanke om svår bakteriell infektion på Skaraborgs Sjukhus Skövde under en period om nio månader. Patienter
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The limits of near field immersion microwave microscopy evaluated by imaging bilayer graphene moiré patterns
Nature Communications, Published online: 20 May 2021; doi:10.1038/s41467-021-23253-2 Here, the authors image twisted bilayer graphene using scanning microwave imaging microscopy, revealing structures with sizes down to 1 nm. They show that is possible by using spontaneously forming nanoscale water menisci that concentrates the microwave fields in small regions.
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Covalency does not suppress O2 formation in 4d and 5d Li-rich O-redox cathodes
Nature Communications, Published online: 20 May 2021; doi:10.1038/s41467-021-23154-4 In this work, authors show that O-redox in 4d and 5d transition metal oxides involves the formation of molecular oxygen trapped in the particles. These results are in accord with observations in 3d oxides and show that the greater covalency of the 4d and 5d oxides does not stabilise peroxo-like species.
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The impact of chromosomal fusions on 3D genome folding and recombination in the germ line
Nature Communications, Published online: 20 May 2021; doi:10.1038/s41467-021-23270-1 How mammalian genomes are packaged and the heritability of structural variations in genome folding is incomplete. Here, the authors investigate the impact of chromosomal fusions on three-dimensional genome topology and meiotic recombination, highlighting the implications of large-scale genome reorganizations on g
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Allostery through DNA drives phenotype switching
Nature Communications, Published online: 20 May 2021; doi:10.1038/s41467-021-23148-2 Most insights on DNA-mediated allostery upon transcription factor (TF) binding were either based on artificial promoters or found to be short-ranged. Here authors use single-molecule FRET and cryo-EM to show that Bacillus subtilis bacteria utilize long-range allostery in a stochastic and reversible phenotype swit
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Observed interannual changes beneath Filchner-Ronne Ice Shelf linked to large-scale atmospheric circulation
Nature Communications, Published online: 20 May 2021; doi:10.1038/s41467-021-23131-x New data from five hot-water drilled boreholes show how atmospheric anomalies affect the circulation beneath Filchner-Ronne Ice Shelf on multi-year time scales. The apparent link of the dense water formation to remote teleconnections is an important step for better predicting contributions to future sea level ris
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Deep learning predicts cardiovascular disease risks from lung cancer screening low dose computed tomography
Nature Communications, Published online: 20 May 2021; doi:10.1038/s41467-021-23235-4 Low dose computed tomography (LDCT) for lung cancer screening offers an opportunity for simultaneous CVD risk estimation in at-risk patients. Here, the authors develop a deep learning model to perform this task, showing human-level performance.
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Structural basis for allosteric regulation of Human Topoisomerase IIα
Nature Communications, Published online: 20 May 2021; doi:10.1038/s41467-021-23136-6 Type 2 DNA topoisomerases (Top2) regulates DNA topology during DNA replication, transcription, and chromosome segregation. Here the authors describe a complete structure of the catalytic core of the human Topo IIα bound to DNA and etoposide, providing insight into the regulation of Topo IIα activities and how ope
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Less forest, more species
Normally, mountain forests are among the most diverse habitats in alpine regions. Yet, as a team from the Alfred Wegener Institute discovered in the Tibetan Plateau, the higher, treeless areas are home to far more species.
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New India cyclone warning as death toll rises
A major new storm was brewing in the Bay of Bengal off India's east coast on Thursday, forecasters warned just days after the biggest cyclone to hit the west of the country in decades left at least 110 people confirmed dead.
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Recruiting participants to the first European Red list of insect taxonomists
The 'Red List of Taxonomists' initiative, funded by the European Union, launches its registration portal, where professionals and citizen scientists are called to register on. The purpose is to build a database of European taxonomy experts in the field of entomology, the biological discipline dedicated to insects. The analysis of these data will elucidate the trends in available expertise, thereby
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Curiosity Stream Is the Streaming Service Tailored for People Who Love To Learn
Once upon a time, channels like Discovery and The Learning Channel sought to enlighten their viewers about the world around them with documentaries and other educational programing . But today, there are fewer and fewer channels committed to this goal, and watered-down "reality television" reigns supreme. It seems the golden age of basic cable television is gone all but gone. Luckily, there's Cur
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Why I'm Not Worried
You might think the world is going to hell in a handbasket based solely on what you read in the news and especially on social media. But the fact is this: man has spent most of his time on this planet in abject squalor fending against disease and hunger. In the last few centuries, by expanding his knowledge of the forces of nature and harnessing them to his advantage, he has begun to overcome thi
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Why is everyone so afraid of AI?
Over and over I read articles and predictions that AI is going to destroy humanity, take over the world, maybe even enslave us. Humanity is on the verge of creating sentient life and we are already afraid of it. We are acting and behaving like many of deities humanity has worshipped through the millennia. Fearful of their creation and doing everything possible to keep it in it's place because the
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New pan-European research reveals double the concern about mental health impact of Lockdown and associated restrictions than physical inactivity
A new pan-European survey funded by the Institute for Scientific Information on Coffee (ISIC) exploring the impact of COVID-19 Lockdowns and associated restrictions (in those countries where there has been no Lockdown), has found that nearly two thirds of adults (61%) expressed concern about their worsening mood; two times higher than those concerned about physical inactivity (24%).
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The Atlantic Daily: Wars Don't Occur in a Vacuum
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox. Israel and Hamas continued trading attacks over the weekend as the latest round of violence in Gaza entered its second week. Death tolls continued to rise , particularly for Palestinians, with doz
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Best CBD Oil For Dogs: 5 Top Products
CBD products are more readily available than ever before. With consumers seeking natural alternative products to treating everyday ailments, it's no surprise that CBD products are so popular. And today, not only are there CBD products for humans, manufacturers have also formulated products meant specifically for dogs. Like humans, dogs also have endocannabinoid systems that are affected by cannab
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Soy kits provide earning power for women entrepreneurs in Malawi
Women's ability to work as entrepreneurs can help alleviate poverty and malnutrition in developing countries. As local governments and development organizations aim to encourage business opportunities, it's important to identify projects suited for women's lives in rural households.
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Sig's Bairdi Bet Pays Off | Deadliest Catch
Stream Full Episodes of Deadliest Catch: discovery+ ► https://www.discoveryplus.com/show/deadliest-catch discovery ► https://go.discovery.com/tv-shows/deadliest-catch/ Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Join us on Facebook: https://www.facebook.com/DeadliestCatch https://www.facebook.com/Discovery Follow us on Twitter: https://twitter.com/DeadliestCatch https://twitter.com/D
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CXCR4/CXCL12-mediated entrapment of axons at the injury site compromises optic nerve regeneration [Neuroscience]
Regenerative failure in the mammalian optic nerve is generally attributed to axotomy-induced retinal ganglion cell (RGC) death, an insufficient intrinsic regenerative capacity, and an extrinsic inhibitory environment. Here, we show that a chemoattractive CXCL12/CXCR4-dependent mechanism prevents the extension of growth-stimulated axons into the distal nerve. The chemokine CXCL12 is chemoattractive
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DNAM-1 regulates Foxp3 expression in regulatory T cells by interfering with TIGIT under inflammatory conditions [Immunology and Inflammation]
Regulatory T (Treg) cells that express forkhead box P3 (Foxp3) are pivotal for immune tolerance. Although inflammatory mediators cause Foxp3 instability and Treg cell dysfunction, their regulatory mechanisms remain incompletely understood. Here, we show that the transfer of Treg cells deficient in the activating immunoreceptor DNAM-1 ameliorated the development of…
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Impact of an alpha helix and a cysteine-cysteine disulfide bond on the resistance of bacterial adhesion pili to stress [Biophysics and Computational Biology]
Escherichia coli express adhesion pili that mediate attachment to host cell surfaces and are exposed to body fluids in the urinary and gastrointestinal tracts. Pilin subunits are organized into helical polymers, with a tip adhesin for specific host binding. Pili can elastically unwind when exposed to fluid flow forces, reducing…
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High energy density and extremely stable supercapacitors based on carbon aerogels with 100% capacitance retention up to 65,000 cycles [Chemistry]
In terms of ideal future energy storage systems, besides the always-pursued energy/power characteristics, long-term stability is crucial for their practical application. Here, we report a facile and sustainable strategy for the scalable fabrication of carbon aerogels with three-dimensional interconnected nanofiber networks and rationally designed hierarchical porous structures, which are based…
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Embryo cryopreservation minimizes cryoinjuries, offers hope for would-be parents
Not all embryo transfers succeed, which gives rise to the practice of freezing extra embryos from an IVF cycle for future transfers. This allows those with at-risk fertility, due to age or treatments such as chemotherapy, to delay their transfer. Researchers introduce a standalone microfluidics system to automate the process of embryo vitrification of replacing water with cryoprotectants, which ex
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Adding antibodies to enhance photodynamic therapy for viral and bacterial disease
Photodynamic therapy, or using light to inactivate viruses, bacteria, and other microbes, has garnered promising results in recent decades for treating respiratory tract infections and some types of cancer. Researchers review the existing approaches and propose adding antibodies to enhance PDT efficacy. They provide a model to help expedite overall PDT development as a rapid response to emergent v
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Melanoma's ripple effect alters distant healthy tissue
Melanoma, a deadly form of skin cancer, alters the metabolism of healthy tissue elsewhere in the body, a study with zebrafish shows. The findings suggest these other tissues could potentially be targeted to help treat cancer. "Tumors rely on a constant supply of nutrients to grow. Instead of competing with tumors for nutrients, other tissues can reprogram their metabolism to be complementary. In
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Google Aims to Make Quantum Computing Viable by 2029
Google makes products for consumers and businesses, but a lot of advanced computer science goes into making those products work. The company began working with neural networks around 20 years ago, enabling many of the cool features we take for granted on the user side. Now, Google is on to its next moonshot with the Quantum AI campus , where it hopes to build a useful, error-corrected quantum com
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Wake steering potentially boosts energy production at US wind plants
Wake steering is a strategy employed at wind power plants involving misaligning upstream turbines with the wind direction to deflect wakes away from downstream turbines, which consequently increases the net production of wind power at a plant. Researchers illustrate how wake steering can increase energy production for a large sampling of commercial land-based U.S. wind power plants. Several were i
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Synaptic transmission: Not a one-way street
When neuroscientists analyzed the exact properties of nerve connections in the brain, they made a startling observation: At a key connection, or synapse, messages are sent against the usual stream of information. The study reports that the signal glutamate likely plays a role in this unusual transmission.
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Electric cars: Special dyes could prevent unnecessary motor replacements
In the near future dyes in electric motors might indicate when cable insulation is becoming brittle and the motor needs replacing. Scientists have developed a new process that enables the dyes to be directly integrated into the insulation. By changing color, they reveal how much the insulating resin layer around the copper wires in the motor has degraded.
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Grazing management of salt marshes contributes to coastal defense
Combining natural salt marsh habitats with conventional dikes may provide a more sustainable alternative for fully engineered flood protection. Researchers studied how salt marsh management can be optimized for coastal defense purposes. They found that grazing by both cattle and small herbivores such as geese and hare and artificial mowing can reduce salt marsh erosion, therefore contributing to n
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Weighting tumor-specific TCR repertoires as a classifier to stratify the immunotherapy delivery in non-small cell lung cancers
Analysis of T cell receptor (TCR) repertoires may contribute to better understanding of the response to immunotherapy. By deep sequencing of the TCR β chain complementarity-determining regions in the paired biopsies and peripheral blood specimens of 31 patients with non–small cell lung cancer (NSCLC) treated with anti–programmed death 1 (PD-1) or PD-ligand 1 (PD-L1) therapy, we developed a previo
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Trimethylamine N-oxide is a new plant molecule that promotes abiotic stress tolerance
Trimethylamine N -oxide (TMAO) is a well-known naturally occurring osmolyte in animals that counteracts the effect of different denaturants related to environmental stress and has recently been associated with severe human chronic diseases. In plants, however, the presence of TMAO has not yet been reported. In this study, we demonstrate that plants contain endogenous levels of TMAO, that it is sy
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Direct evidence of acid-base interactions in gecko adhesion
While it is generally accepted that van der Waals (vdW) forces govern gecko adhesion, several studies indicate contributions from non-vdW forces and highlight the importance of understanding the adhesive contact interface. Previous work hypothesized that the surface of gecko setae is hydrophobic, with nonpolar lipid tails exposed on the surface. However, direct experimental evidence supporting th
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Table-top extreme ultraviolet second harmonic generation
The lack of available table-top extreme ultraviolet (XUV) sources with high enough fluxes and coherence properties has limited the availability of nonlinear XUV and x-ray spectroscopies to free-electron lasers (FELs). Here, we demonstrate second harmonic generation (SHG) on a table-top XUV source by observing SHG near the Ti M 2,3 edge with a high-harmonic seeded soft x-ray laser. Furthermore, th
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Critical slowing down in circuit quantum electrodynamics
Critical slowing down of the time it takes a system to reach equilibrium is a key signature of bistability in dissipative first-order phase transitions. Understanding and characterizing this process can shed light on the underlying many-body dynamics that occur close to such a transition. Here, we explore the rich quantum activation dynamics and the appearance of critical slowing down in an engin
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Quantum monitoring of cellular metabolic activities in single mitochondria
Free radicals play a vital role in all kinds of biological processes including immune responses. However, free radicals have short lifetimes and are highly reactive, making them difficult to measure using current methods. Here, we demonstrate that relaxometry measurement, or T1, inherited from the field of diamond magnetometry can be used to detect free radicals in living cells with subcellular r
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Transient rhyolite melt extraction to produce a shallow granitic pluton
Rhyolitic melt that fuels explosive eruptions often originates in the upper crust via extraction from crystal-rich sources, implying an evolutionary link between volcanism and residual plutonism. However, the time scales over which these systems evolve are mainly understood through erupted deposits, limiting confirmation of this connection. Exhumed plutons that preserve a record of high-silica me
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Comparative evaluation of isogenic mesodermal and ectomesodermal chondrocytes from human iPSCs for cartilage regeneration
Generating phenotypic chondrocytes from pluripotent stem cells is of great interest in the field of cartilage regeneration. In this study, we differentiated human induced pluripotent stem cells into the mesodermal and ectomesodermal lineages to prepare isogenic mesodermal cell–derived chondrocytes (MC-Chs) and neural crest cell–derived chondrocytes (NCC-Chs), respectively, for comparative evaluat
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Simplifying inverse materials design problems for fixed lattices with alchemical chirality
Brute-force compute campaigns relying on demanding ab initio calculations routinely search for previously unknown materials in chemical compound space (CCS), the vast set of all conceivable stable combinations of elements and structural configurations. Here, we demonstrate that four-dimensional chirality arising from antisymmetry of alchemical perturbations dissects CCS and defines approximate ra
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Preservation of lagging strand integrity at sites of stalled replication by Pol {alpha}-primase and 9-1-1 complex
During genome duplication, the replication fork encounters a plethora of obstacles in the form of damaged bases, DNA–cross-linked proteins, and secondary structures. How cells protect DNA integrity at sites of stalled replication is currently unknown. Here, by engineering "primase deserts" into the Caenorhabditis elegans genome close to replication-impeding G-quadruplexes, we show that de novo DN
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Genome-scale CRISPR-Cas9 screen of Wnt/{beta}-catenin signaling identifies therapeutic targets for colorectal cancer
Aberrant activation of Wnt/β-catenin pathway is a key driver of colorectal cancer (CRC) growth and of great therapeutic importance. In this study, we performed comprehensive CRISPR screens to interrogate the regulatory network of Wnt/β-catenin signaling in CRC cells. We found marked discrepancies between the artificial TOP reporter activity and β-catenin–mediated endogenous transcription and redu
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Guidestar-free image-guided wavefront shaping
Optical imaging through scattering media is a fundamental challenge in many applications. Recently, breakthroughs such as imaging through biological tissues and looking around corners have been obtained via wavefront-shaping approaches. However, these require an implanted guidestar for determining the wavefront correction, controlled coherent illumination, and most often raster scanning of the sh
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Functional coordination of BET family proteins underlies altered transcription associated with memory impairment in fragile X syndrome
Bromodomain and extraterminal proteins (BET) are epigenetic readers that play critical roles in gene regulation. Pharmacologic inhibition of the bromodomain present in all BET family members is a promising therapeutic strategy for various diseases, but its impact on individual family members has not been well understood. Using a transcriptional induction paradigm in neurons, we have systematicall
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Pristine quantum criticality in a Kondo semimetal
The observation of quantum criticality in diverse classes of strongly correlated electron systems has been instrumental in establishing ordering principles, discovering new phases, and identifying the relevant degrees of freedom and interactions. At focus so far have been insulators and metals. Semimetals, which are of great current interest as candidate phases with nontrivial topology, are much
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Large-scale reptile extinctions following European colonization of the Guadeloupe Islands
Large-scale extinction is one of the defining challenges of our time, as human processes fundamentally and irreversibly reshape global ecosystems. While the extinction of large animals with popular appeal garners widespread public and research interest, the importance of smaller, less "charismatic" species to ecosystem health is increasingly recognized. Benefitting from systematically collected f
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Large-scale, robust mushroom-shaped nanochannel array membrane for ultrahigh osmotic energy conversion
The osmotic energy, a large-scale clean energy source, can be converted to electricity directly by ion-selective membranes. None of the previously reported membranes meets all the crucial demands of ultrahigh power density, excellent mechanical stability, and upscaled fabrication. Here, we demonstrate a large-scale, robust mushroom-shaped (with stem and cap) nanochannel array membrane with an ult
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Rapid imaging of special nuclear materials for nuclear nonproliferation and terrorism prevention
We introduce a neutron-gamma emission tomography (NGET) technique for rapid detection, three-dimensional imaging, and characterization of special nuclear materials like weapons-grade plutonium and uranium. The technique is adapted from fundamental nuclear physics research and represents a previously unexplored approach to the detection and imaging of small quantities of these materials. The metho
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Scaffold-mediated CRISPR-Cas9 delivery system for acute myeloid leukemia therapy
Leukemia stem cells (LSCs) sustain the disease and contribute to relapse in acute myeloid leukemia (AML). Therapies that ablate LSCs may increase the chance of eliminating this cancer in patients. To this end, we used a bioreducible lipidoid-encapsulated Cas9/single guide RNA (sgRNA) ribonucleoprotein [lipidoid nanoparticle (LNP)–Cas9 RNP] to target the critical gene interleukin-1 receptor access
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Cevipabulin-tubulin complex reveals a novel agent binding site on {alpha}-tubulin with tubulin degradation effect
Microtubules, composed of αβ-tubulin heterodimers, have remained popular anticancer targets for decades. Six known binding sites on tubulin dimers have been identified thus far, with five sites on β-tubulin and only one site on α-tubulin, hinting that compounds binding to α-tubulin are less well characterized. Cevipabulin, a microtubule-active antitumor clinical candidate, is widely accepted as a
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Targeting nucleotide metabolism as the nexus of viral infections, cancer, and the immune response
Virus-infected cells and cancers share metabolic commonalities that stem from their insatiable need to replicate while evading the host immune system. These similarities include hijacking signaling mechanisms that induce metabolic rewiring in the host to up-regulate nucleotide metabolism and, in parallel, suppress the immune response. In both cancer and viral infections, the host immune cells and
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Lyme bacteria survive antibiotics, even months later
The bacteria that cause Lyme disease can survive in organ tissue after treatment with a full course of antibiotics months after infection, according to a new study with non-human primates. The study results seem to support claims of lingering symptoms some patients who have received antibiotic treatment for the disease have reported. Researchers at Tulane National Primate Research Center studied
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Different levels of conservation protection favor distinct communities
Habitats under different levels of protection host marked / contrasted different communities of plants, birds and fish, despite having similar numbers of species, according to a study publishing 19th May, 2021 in the open-access journal PLOS Biology. The research, led by Nicolas Loiseau at the CNRS and University of Montpellier, highlights the importance of diverse conservation strategies to maxim
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Monitoring species condemned to extinction may help save others as global temperatures rise
The White-tailed Swallow, Hirundo megaensis, and Ethiopian Bush-crow, Zavattariornis stresemanni, are living in 'climatic lifeboats' with their tiny ranges restricted on all sides by temperature and rainfall patterns. Even under moderate climate warming, models predict a severe loss of suitable climate for these birds within the next 50 years—dramatically heightening their risk of extinction.
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Children's Tumor Foundation announces revised diagnostic criteria for NF1
The Children's Tumor Foundation (CTF) today announced the publication of updated diagnostic criteria for the genetic disorder neurofibromatosis type 1 (NF1) in Genetics in Medicine, the official journal of the American College of Medical Genetics and Genomics. The new publication is the result of an extensive, multi-year collaborative effort of over 90 leading neurofibromatosis (NF) experts from a
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Texas kids hint vax rates have dropped in pandemic
Despite expert recommendations that children continue to get regularly scheduled vaccines during the COVID-19 pandemic, rates of vaccinations decreased in several states. Researchers looked at childhood immunization rates in Texas to see what effect the COVID-19 pandemic may have had on childhood immunizations in 2020, using data from a statewide immunization registry to determine how immunizatio
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Research team develops new class of soft materials
"I think you're on mute." This was the most-used phrase of 2020, according to Human Resources Online. Emblazoned on T-shirts and embossed on coffee-mugs, we used the meme to make fun of ourselves while learning video-conferencing tools like Zoom and Microsoft's Teams.
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Study points to potential treatment for citrus disease
Brazil is the world leader in sweet orange production, but citrus cultivation in the region faces constant threats concerning the availability of water and the outbreak of diseases. New research published in the Journal of Applied Microbiology indicates that a fatty acid called hexanoic acid may help protect against one such problem: citrus canker, a bacterial infection that causes brownish erupti
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Sleep loss after spouse's death can harm immune health
Sleep loss that often follows the death of a spouse can have a negative long-term impact on the health of the widowed spouse, according to new research. "We already know from existing research that widowed spouses are at greater risk of heart problems or death, especially in the months following the loss of their partner," says Lydia Wu, a psychology graduate student at Rice University and lead a
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Bees interrupted
During a 15-year study of wild bees visiting blueberry fields during their blooming season, researchers caught an unexpected glimpse of how extreme weather events can impact bee populations highlighting the need for more long-term studies, says a Michigan State University researcher.
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To underscore my previous point. In the Last Decade we had – 35 Major Sci Fi level Breakthroughs reported just on /r/Futorology. This year, 5 months in – and we have had over 500 such breakthroughs reported on /r/Futurology. Next Year, expect this number to rise at massive exponential intervals.
This is in response to a comment I never actually answered – as I am answering it here. "What was the rise in progress technologically – over the last decade". That number queried – that gave way to 35 Major Sci Fi level breakthroughs – arguably more – so to answer the question the pace of technological acceleration rose a mere .03% over the last decade. It previously, took a mere decade to see t
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Thoughts on SUV
Recently I made a post in a big german-speaking subreddit ( r/de ) because I was interessted how people see the future of mobility/transportation. What took me a bit by suprise was that people really misliked/downvoted my critique on SUVs. Feeling like I had to make people aware of the disadvantages of SUVs, I opened a new post where I pointed some arguments out. Turned out this post got deleted
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Combatting climate change with carbon farming
Scientists, governments and corporations worldwide are racing against the clock to fight climate change, and part of the solution might be in our soil. By adding carbon from the atmosphere to depleted soil, farmers can both increase their yields and reduce emissions. A cover story in Chemical & Engineering News, the weekly newsmagazine of the American Chemical Society, explores what it would take
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Overwintering fires in boreal forests
Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03437-y Large forest fires in Alaska and the Northwest Territories can 'overwinter' and then reignite in the following fire season, contributing up to one-third of the burned area in individual years.
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MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration
Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03556-6 The natural antisense transcript MAPT-AS1 interferes with translation of mRNA transcript into tau protein in the brain and may represent a general mechanism for controlling levels of intrinsically disordered proteins, with particular relevance for neurodegeneration.
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Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions
Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03563-7 Specialized somatosensory neurons that express Gαi-interacting protein (GINIP) promote tissue repair in a model of UV-induced skin damage by secreting the neuropeptide TAFA4, which regulates skin-resident macrophages to release IL-10 and limit fibrosis.
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The nutritional quality of cereals varies geospatially in Ethiopia and Malawi
Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03559-3 Geospatial variation in the micronutrient composition (calcium, iron, selenium and zinc) of staple cereal grains is nutritionally important at subnational scales in Ethiopia and Malawi; these data could be used to improve surveillance of micronutrient deficiencies in the region.
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Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection
Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03566-4 Upon Salmonella invasion of the mammalian cytosol, ubiquitylation of a non-proteinaceous substrate—the lipid A moiety of bacterial lipopolysaccharide—by the E3 ubiquitin ligase RNF213 marks the bacteria as cargo for antibacterial autophagy.
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The data-driven future of high-energy-density physics
Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03382-w This Perspective discusses how high-energy-density physics could tap the potential of AI-inspired algorithms for extracting relevant information and how data-driven automatic control routines may be used for optimizing high-repetition-rate experiments.
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Iron and nickel vapours are present in most comets
Nature, Published online: 19 May 2021; doi:10.1038/d41586-021-01265-8 The detection of iron and nickel vapours in a broad range of Solar System comets, and of nickel vapour in a comet from outside the Solar System, provides a glimpse into the organic chemistry of young planetary systems.
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Host ubiquitin protein tags lipid to fight bacteria
Nature, Published online: 19 May 2021; doi:10.1038/d41586-021-01267-6 Host cells battle invading bacteria using a degradation process facilitated by the protein ubiquitin. The discovery of the host enzyme responsible and its bacterial target reveals that this process defies convention.
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Fluorescent light buzz could power more efficient computers
The property that makes fluorescent lights buzz could power a new generation of more efficient computing devices that store data with magnetic fields, rather than electricity. Researchers have developed a material that's at least twice as "magnetostrictive" and far less costly than other materials in its class. In addition to computing, it could also lead to better magnetic sensors for medical an
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Nickel atoms detected in the cold gas around interstellar comet 2I/Borisov
Unbound nickel atoms and other heavy elements have been observed in very hot cosmic environments, including the atmospheres of ultra-hot exoplanets and evaporating comets that ventured too close to our Sun or other stars. A new study conducted by JU researchers reveals the presence of nickel atoms in the cold gasses surrounding the interstellar comet 2I/Borisov. The team's finding is being publish
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Good results with online CBT for atopic eczema
The common skin disease atopic eczema (AE) impacts heavily on the life quality and general health of sufferers. Researchers at Karolinska Institutet have now evaluated its treatment with internet-delivered cognitive behavioural therapy (iCBT). The study suggests that patients feel better after iCBT compared with a control group who received only traditional treatment. The results, which are publis
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Protein simulation, experiments unveil clues on origins of Parkinson's disease
Parkinson's disease is the second most common neurodegenerative disease and affects more than 10 million people around the world. To better understand the origins of the disease, researchers from Penn State College of Medicine and The Hebrew University of Jerusalem have developed an integrative approach, combining experimental and computational methods, to understand how individual proteins may fo
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Hidden in plain sight, 4 new sponges get creative names
Four new species of sponge were lying undiscovered in plain sight. The ocean is a big place with many mysteries. Humans have mapped no more than 20% of the sea, and explored less. Even the kelp forests of Southern California—among the best studied patches of ocean on the planet—hide species that science has not yet described. A paper in the journal Zootaxa describes the four new species of sponge
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World's first, satellite-based monitoring system goes global to help save coral reefs
The current prognosis for our world's coral reefs is bleak. With ever warming, more polluted and acidic oceans, models predict that 70% to 90% of coral reefs will be lost by 2050. To date, there has not been a global system in place to monitor coral reefs under the stresses that may lead to their deaths. But scientists now have a tool to monitor the global health of coral reefs, bringing new hope
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What are the effects of inappropriate prescriptions in older adults?
Individuals are often prescribed increasing numbers of medications as they age, and while many of these prescriptions are justifiable, some may be inappropriate. A recent analysis published in the British Journal of Clinical Pharmacology examined the results of all studies investigating associations between potentially inappropriate prescribing–which includes prescribing medications that may not
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Magnetically propelled cilia power climbing soft robots and microfluidic pumps (video)
The rhythmic motions of hair-like cilia move liquids around cells or propel the cells themselves. In nature, cilia flap independently, and mimicking these movements with artificial materials requires complex mechanisms. Now, researchers reporting in ACS Applied Materials & Interfaces have made artificial cilia that move in a wave-like fashion when a rotating magnetic field is applied, making them
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Study examines young athletes' knee health after returning to sport following ACL reconstruction
One-quarter to one-third of young, active patients who undergo anterior cruciate ligament reconstruction experience a second ACL injury after they return to sport (RTS). New research indicates that young athletes who feel confident about their knee health at the time of medical clearance for sports participation after ACL surgery have a higher likelihood of meeting all RTS criteria related to phys
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NYU Abu Dhabi researchers develop non-contact probe to analyze single cells within tumors
NYU Abu Dhabi (NYUAD) researchers have developed a special noncontact multi-physics probe (NMP) that enables them to collect cytoplasmic samples from single tumor cells without disrupting their spatial configurations in the original tissue. As a result, the NMP will facilitate advanced studies that could improve the current understanding of the basic building blocks of diseases, including cancer a
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Peştera Muierii levde för 35 000 år sen – nu är hennes dna kartlagt
Forskare har lyckats få fram det kompletta dna:t från skallben, tillhörande kvinnan Peştera Muierii 1 – som levde i Rumänien för 35 000 år sedan. – Hon är lite mer lik oss än de individer i Europa som är femtusen år äldre, säger Uppsalaforskaren Mattias Jakobsson som lett studien. – Men skillnaden är mycket mindre än vi trodde. Vi kan se att hon inte är någon direkt föregångare till oss som lever
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PFAS kan förorena miljön genom vårt avfall
Vanliga produkter i våra hem innehåller högfluorerade kemikalier, PFAS, som gör dem vatten- och fettavstötande. En ny studie från Umeå visar att giftigt PFAS kan läcka ut i naturen, när dessa produkter hamnar i hushållsavfall. Högfluorerade kemikalier, så kallade PFAS, är en stor grupp av tusentals kemikalier som finns i en mängd olika produkter, från smutsavvisande mattor, fettavstötande livsmed
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A machine learning model behind COVID-19 vaccine development
When starting a vaccine program, scientists generally have anecdotal understanding of the disease they're aiming to target. When COVID-19 surfaced over a year ago, there were so many unknowns about the fast-moving virus that scientists had to act quickly and rely on new methods and techniques just to even begin understanding the basics of the disease.
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Lockdowns may affect children's fitness — Study
Research indicates that strict COVID-19 lockdowns might be responsible for delaying normal cardiorespiratory development in children. The study found that a group of 12-14-year-olds in Spain – who were tested pre-pandemic in November 2019 and then again in November 2020 – displayed lower levels of fitness than would be expected with maximal oxygen intake (VO2 max) development, which increases with
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TPU scientists: Effective application of power transformers to reduce cost of electrical energy
Scientists from Tomsk Polytechnic University and Université Grenoble Alpes (France) have proposed a more accurate method for loading capability assessment of power transformers. As an example, the scientists defined the loading capability of the power transformer in Tomsk and Grenoble. The research findings are published in the International Journal of Electrical Power and Energy Systems (IF: 3,58
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A new rapid test detects a coronavirus infection in 10 minutes
An antigen-based detection technique developed by University of Helsinki researchers could be used to analyse as many as 500 samples per hour. In a recently completed study, the rapid test was able to diagnose a viral infection almost as accurately as PCR tests, which are known for their sensitivity. The new rapid test format can also be used to rapidly diagnose other respiratory infections.
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An automated box on wheels — with personality
Robots are becoming more and more omnipresent in our lives, even though we may not notice. New research shows that when a boxy motorized hospital robot can talk, people find it funny and engaging. And that may help people be more willing to accept new technologies, like robots, in their everyday lives.
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VOYAGE phase 3: Dupilumab significantly reduced asthma exacerbations in children age 6-11
Results from the VOYAGE study of dupilumab (Dupixent) showed that the monoclonal antibody significantly reduced exacerbations in children ages 6-11 with uncontrolled moderate-to-severe asthma, compared to placebo, according to research presented at the ATS 2021 International Conference. VOYAGE (NCT02948959) is a recently completed randomized, placebo-controlled double-blind multicenter phase 3 cli
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