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Evidence for a Northern Hemispheric trigger of the 100,000-y glacial cyclicity [Earth, Atmospheric, and Planetary Sciences]
The causes of the Mid-Pleistocene Transition, the shift from ∼41-ky to 100-ky interglacial–glacial cycles and more intense ice ages, remain intensely debated, as this fundamental change occurred between ∼1,250 and 650 ka without substantial changes in astronomical climate forcings. Recent studies disagree about the relative importance of events and processes…
14h
The Shh/Gli3 gene regulatory network precedes the origin of paired fins and reveals the deep homology between distal fins and digits [Developmental Biology]
One of the central problems of vertebrate evolution is understanding the relationship among the distal portions of fins and limbs. Lacking comparable morphological markers of these regions in fish and tetrapods, these relationships have remained uncertain for the past century and a half. Here we show that Gli3 functions in…
14h
Comparing information diffusion mechanisms by matching on cascade size [Applied Mathematics]
Do some types of information spread faster, broader, or further than others? To understand how information diffusions differ, scholars compare structural properties of the paths taken by content as it spreads through a network, studying so-called cascades. Commonly studied cascade properties include the reach, depth, breadth, and speed of propagation….
14h
A regulatory network of microRNAs confers lineage commitment during early developmental trajectories of B and T lymphocytes [Immunology and Inflammation]
The commitment of hematopoietic multipotent progenitors (MPPs) toward a particular lineage involves activation of cell type–specific genes and silencing of genes that promote alternate cell fates. Although the gene expression programs of early–B and early–T lymphocyte development are mutually exclusive, we show that these cell types exhibit significantly correlated microRNA…
14h
Emergence of a compositional neural code for written words: Recycling of a convolutional neural network for reading [Psychological and Cognitive Sciences]
The visual word form area (VWFA) is a region of human inferotemporal cortex that emerges at a fixed location in the occipitotemporal cortex during reading acquisition and systematically responds to written words in literate individuals. According to the neuronal recycling hypothesis, this region arises through the repurposing, for letter recognition,…
14h
How the interplay of molecular and colloidal scales controls drying of microgel dispersions [Applied Physical Sciences]
Bringing an aqueous dispersion or solution into open air leads to water evaporation. The resulting drying process initiates the buildup of spatial heterogeneities, as nonvolatile solutes and colloids concentrate. Such composition gradients associate with mesostructure gradients, which, in turn, impact flows within these multicomponent systems. In this work, we investigate…
14h
Magmatic thickening of crust in non-plate tectonic settings initiated the subaerial rise of Earth's first continents 3.3 to 3.2 billion years ago [Earth, Atmospheric, and Planetary Sciences]
When and how Earth's earliest continents—the cratons—first emerged above the oceans (i.e., emersion) remain uncertain. Here, we analyze a craton-wide record of Paleo-to-Mesoarchean granitoid magmatism and terrestrial to shallow-marine sedimentation preserved in the Singhbhum Craton (India) and combine the results with isostatic modeling to examine the timing and mechanism of…
14h
Geometry and dynamics link form, function, and evolution of finch beaks [Biophysics and Computational Biology]
Darwin's finches are a classic example of adaptive radiation, exemplified by their adaptive and functional beak morphologies. To quantify their form, we carry out a morphometric analysis of the three-dimensional beak shapes of all of Darwin's finches and find that they can be fit by a transverse parabolic shape with…
14h
Active math and grammar learning engages overlapping brain networks [Psychological and Cognitive Sciences]
We here demonstrate common neurocognitive long-term memory effects of active learning that generalize over course subjects (mathematics and vocabulary) by the use of fMRI. One week after active learning, relative to more passive learning, performance and fronto-parietal brain activity was significantly higher during retesting, possibly related to the formation and…
14h
Air pollution interacts with genetic risk to influence cortical networks implicated in depression [Environmental Sciences]
Air pollution is a reversible cause of significant global mortality and morbidity. Epidemiological evidence suggests associations between air pollution exposure and impaired cognition and increased risk for major depressive disorders. However, the neural bases of these associations have been unclear. Here, in healthy human subjects exposed to relatively high air…
14h
Modular origins of high-amplitude cofluctuations in fine-scale functional connectivity dynamics [Neuroscience]
The topology of structural brain networks shapes brain dynamics, including the correlation structure of brain activity (functional connectivity) as estimated from functional neuroimaging data. Empirical studies have shown that functional connectivity fluctuates over time, exhibiting patterns that vary in the spatial arrangement of correlations among segregated functional systems. Recently, an…
14h
Stochastic chromatin packing of 3D mitotic chromosomes revealed by coherent X-rays [Applied Physical Sciences]
DNA molecules are atomic-scale information storage molecules that promote reliable information transfer via fault-free repetitions of replications and transcriptions. Remarkable accuracy of compacting a few-meters-long DNA into a micrometer-scale object, and the reverse, makes the chromosome one of the most intriguing structures from both physical and biological viewpoints. However, its…
14h
Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type Ca2+ channels at ER-PM ȷunctions [Physiology]
In mammalian brain neurons, membrane depolarization leads to voltage-gated Ca2+ channel-mediated Ca2+ influx that triggers diverse cellular responses, including gene expression, in a process termed excitation–transcription coupling. Neuronal L-type Ca2+ channels, which have prominent populations on the soma and distal dendrites of hippocampal neurons, play a privileged role in excitation–transcrip
14h
COVID-19 within families amplifies the prosociality gap between adolescents of high and low socioeconomic status [Economic Sciences]
COVID-19 has had worse health, education, and labor market effects on groups with low socioeconomic status (SES) than on those with high SES. Little is known, however, about whether COVID-19 has also had differential effects on noncognitive skills that are important for life outcomes. Using panel data from before and…
14h
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance [Biophysics and Computational Biology]
Protein kinase inhibitors are potent anticancer therapeutics. For example, the Bcr-Abl kinase inhibitor imatinib decreases mortality for chronic myeloid leukemia by 80%, but 22 to 41% of patients acquire resistance to imatinib. About 70% of relapsed patients harbor mutations in the Bcr-Abl kinase domain, where more than a hundred different…
14h
Nitrous oxide emissions from agricultural soils challenge climate sustainability in the US Corn Belt [Environmental Sciences]
Agricultural landscapes are the largest source of anthropogenic nitrous oxide (N2O) emissions, but their specific sources and magnitudes remain contested. In the US Corn Belt, a globally important N2O source, in-field soil emissions were reportedly too small to account for N2O measured in the regional atmosphere, and disproportionately high N2O…
14h
Discovery of nondiazotrophic Trichodesmium species abundant and widespread in the open ocean [Microbiology]
Filamentous and colony-forming cells within the cyanobacterial genus Trichodesmium might account for nearly half of nitrogen fixation in the sunlit ocean, a critical mechanism that sustains plankton's primary productivity. Trichodesmium has long been portrayed as a diazotrophic genus. By means of genome-resolved metagenomics, here we reveal that nondiazotrophic Trichodesmium species…
14h
DNA self-organization controls valence in programmable colloid design [Physics]
Just like atoms combine into molecules, colloids can self-organize into predetermined structures according to a set of design principles. Controlling valence—the number of interparticle bonds—is a prerequisite for the assembly of complex architectures. The assembly can be directed via solid "patchy" particles with prescribed geometries to make, for example, a…
14h
Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistance [Biophysics and Computational Biology]
Antibiotic resistance is a major threat to global health; this problem can be addressed by the development of new antibacterial agents to keep pace with the evolutionary adaptation of pathogens. Computational approaches are essential tools to this end since their application enables fast and early strategical decisions in the drug…
14h
Land carbon sink of the Tibetan Plateau may be overestimated without accounting for the aquatic carbon export [Biological Sciences]
Wei et al. (1) report a net carbon dioxide (CO2) sink of the Tibetan Plateau (TP) by using a regional-scale eddy covariance observation network. They also project a substantial enhancement of the CO2 sink under a future warming and increasingly wet climate across the TP with modeling efforts. The CO2…
14h
Probing the electronic properties of the electrified silicon/water interface by combining simulations and experiments [Chemistry]
Silicon (Si) is broadly used in electrochemical and photoelectrochemical devices, where the capacitive and Faradaic reactions at the Si/water interfaces are critical for signal transduction or noise generation. However, probing the electrified Si/water interface at the microscopic level remains a challenging task. Here we focus on hydrogenated Si surfaces in…
14h
A solar-to-chemical conversion efficiency up to 0.26% achieved in ambient conditions [Engineering]
Artificial photosynthesis in ambient conditions is much less efficient than the solar-to-biomass conversion (SBC) processes in nature. Here, we successfully mimic the NADP-mediated photosynthetic processes in green plants by introducing redox moieties as the electron acceptors in the present conjugated polymeric photocatalyst. The current artificial process substantially promotes the charge…
14h
Cell division in the shoot apical meristem is a trigger for miR156 decline and vegetative phase transition in Arabidopsis [Plant Biology]
What determines the rate at which a multicellular organism matures is a fundamental question in biology. In plants, the decline of miR156 with age serves as an intrinsic, evolutionarily conserved timer for the juvenile-to-adult phase transition. However, the way in which age regulates miR156 abundance is poorly understood. Here, we…
14h
Reply to Song and Wang: Terrestrial CO2 sink dominates net ecosystem carbon balance of the Tibetan Plateau [Letters (Online Only)]
We welcome the letter of Song and Wang (1) regarding aquatic carbon (C) export on the Tibetan Plateau (TP) and appreciate the opportunity to clarify our thinking. The net ecosystem C balance (NECB) includes CO2 and CH4 exchange, volatile organic C loss, and particulate and aquatic C transport. By contrast,…
14h
How to lessen seasonal affective disorder symptoms
As the days continue to get shorter and colder, it is likely that you or someone you know has started to experience seasonal mood changes. Symptoms such as a loss of energy, a dip in mood, a lack of interest, or trouble focusing can often be attributed to the lack of daylight we take in—and when they get too disruptive, can be indicative of a mood disorder called seasonal affective disorder (or S
15h
Best Computer Monitors for Work or Play
If you spend a lot of time in front of a screen , it pays to have one of the best computer monitors. The right monitor can shape your working or gaming experience, whether you're using your computer for professional or general use. Choosing a new monitor can feel daunting: you need to consider monitor type, size, and resolution, and dive into specs like response time and refresh rate—all while ke
15h
A Long-Winded Letter To Doomers. Please stop being so dismissive.
Hi. This is my first post here and I hope I get it right. English is not my first language, but Reddit uses it and in order to be part of the discussion here, I have to use it as well. I know that everyone is entitled to have an opinion. That in Reddit, they are entitled to comment. I don't intend to stop them from doing that, but I do intend to explain why I feel they are … how should I put it…
15h
Regarding Fermi paradox
Is it possible that extraterrestrials don't consider our intelligence Intelligent enough for them to actually contact us. Like we're mere animals like how we see our dogs and such, and species like us are just common in the universe. That we won't go farther than where we are now technologically. For instance, they see that we will just render ourselves extinct through nuclear warfare. submitted
15h
The catastrophic consequences of criminalising livelihoods in West Africa
We were in Obalende: a bustling working-class neighborhood of office buildings, shops and residential areas, on Lagos Island, Nigeria. During the day, the neighborhood teems with small market stalls selling all manner of things, from fruit and vegetables to electronics, tailored clothes and everyday household items.
16h
Ångest lindrades med träning tre gånger i veckan
Ångestnivån sjönk hos majoriteten av patienter med ångestsyndrom som deltog i ett tolv veckor långt fysiskt träningsprogram. Det gällde även för dem som levt med ångest i över tio års tid. Deltagarna lottades till gruppträning under tolv veckor, antingen måttlig eller mer intensiv. – Ju högre träningsintensitet desto större förbättring i ångestsymtom, konstaterar Malin Henriksson, doktorand på Sa
16h
Ditching fossil fuels will have immediate health benefits for millions, and world leaders must seize the chance
Carbon dioxide (CO₂) emitted by burning fossil fuels for energy today will only be removed from the atmosphere by natural sinks—like forests and the ocean—in the next 300 to 1,000 years. That means the climate benefits of transitioning to clean energy become apparent on far longer timescales than political term limits and election cycles. A US study, for example, found that deep cuts to emissions
16h
Facebook, the metaverse and the monetisation of higher education
The metaverse is a virtual world in which users, represented by an avatar, can shop, socialize, take part in leisure activities—and learn. Its development has become a priority for many tech companies, including Facebook (which recently changed its company name to Meta) and Microsoft.
17h
Irrigation, water management play key roles in smoothing drought impacts
A new study examining more than 100 years of agricultural production and weather data in the United States suggests stored water plays an important role in providing resilience to drought. The findings also suggest water management strategies, which differ across the U.S., play a key role in how different areas of the country respond to weather anomalies.
17h
Do Europeans think social media is harmful?
If you are undecided about whether social media is truly harmful to young people's mental well-being, you are not alone. Even scientists cannot agree on social media's effect on teenagers' mental health. Some researchers provide evidence that increasing social media usage is linked to rising mental health problems, while others argue social media could have positive effects. Yet others consider mo
17h
New research reveals impact of homelessness on EU citizens living in Britain
New research led by Heriot-Watt University and the Institute for Public Policy Research (IPPR) for homelessness charity Crisis has revealed people from EU countries living in Britain are nearly three times more likely to experience rough sleeping than the general adult population. They are also twice as likely to experience homelessness overall because they struggle to access support.
17h
Intensified solar thermochemical carbon dioxide splitting over iron-based perovskite
Practical solar fuel production via two-step solar thermochemical CO2 splitting (STCS), a promising method. We demonstrate that FeNi alloy embedded in perovskite substrate enables near complete CO2 splitting and record CO production rate of 381 mL g-1 min-1 (STP). This unprecedented performance is ascribed to stabilization of oxidized Fe cations by in-situ involving into robust perovskite matrix.
17h
What drives interorganizational resilience?
Many organizations are today facing challenges that make them increasingly vulnerable, and few organizations demonstrate high levels of resilience. For her Ph.D. research, Jennifer van den Berg explored whether and how power dynamics influence organizational resilience, specifically by looking at employee participation and collaborative practices. She defends her thesis on November 12th at the dep
17h
Scientists improve Dyson imaging spectrometer for water color detection
Ocean color is hard to observe, as water scatters sunlight and only visible light can be transmitted. As water deepens, the intensity of light transmitted through the water decreases. Traditional concentric system spectrometers, with broad spectrum and high spectral and spatial resolution, can meet part of the observation requirements. However, the Dyson structure is hard to process and assemble d
17h
Who's the boss? Male and female Guinea baboons are equally successful at leading the group
The sun rises over the Senegalese savannah. The Guinea baboons have spent the night on their sleeping trees and set off together to forage. In order to depart simultaneously as a group and roam together during the day, the animals have to coordinate well. Researchers from the German Primate Center (DPZ) – Leibniz Institute for Primate Research have studied which animals lead the group and how they
17h
How unlocking nature's power can help the UK step up its fight against climate change
World leaders have been gathering at COP26, the UN climate summit in Glasgow, against a backdrop of flooded homes, closed roads and canceled trains across the UK caused by extreme weather. These conditions are a stark reminder that as well as dramatically reducing our carbon emissions, we must also begin adapting to a climate that is already irreversibly changing.
17h
The hidden behavior of supercapacitor materials
Researchers from the University of Surrey's Advanced Technology Institute (ATI) and the University of São Paulo have developed a new analysis technique that will help scientists improve renewable energy storage by making better supercapacitors.
17h
Better understanding of blast furnace operations for more sustainable steel production
Worldwide, we produce more than two gigatons of steel a year, the vast majority of which is produced in blast furnaces. In order to make the blast furnace process more sustainable—less energy consumption, less maintenance, less CO2 emissions—it helps to increase the understanding of how these blast furnaces work. In his doctoral research, Tim Nijssen arrived at a model that can quantitatively desc
17h
One billion face heat stress risk from 2°C rise
The numbers of people in regions across the world affected by extreme heat stress—a potentially fatal combination of heat and humidity—could increase nearly 15-fold if the world's temperature rise reaches 2 degrees Celsius.
17h
How small countries can make a big impact on climate change | Nicola Sturgeon
When it comes to tackling climate change, the size of a country doesn't matter — it's their ambition that counts, says First Minister of Scotland Nicola Sturgeon. In a rousing talk, she shares examples of small nations — from Bhutan and Fiji to her own Scotland — whose leadership and climate action are galvanizing change on the international stage. (Followed by a brief Q&A with TED's global cur
17h
Modified silk cloth keeps skin cooler than cotton
A team of researchers affiliated with a host of entities in China and one in the U.S. has developed a modified textile that can keep skin cooler than materials made of cotton. In their paper published in the journal Nature Nanotechnology, the group describes their approach to developing garments that are cooler when worn in outdoor conditions.
17h
Image: Hubble captures the shredded remains of a cosmic explosion
These cosmic ribbons of gas have been left behind by a titanic stellar explosion called a supernova. DEM L249 is thought to be the remnant of a Type 1a supernova, the death of a white dwarf star. White dwarf stars are usually stable, but in a binary system—two stars orbiting each other—a white dwarf can gravitationally pull so much matter from its companion that it reaches critical mass and explod
17h
Magnetic brain stim leads to remission for patients with severe depression
A new type of magnetic brain stimulation brought rapid remission to almost 80% of participants with severe depression in a new study. The treatment, known as Stanford accelerated intelligent neuromodulation therapy (SAINT) or simply Stanford neuromodulation therapy, is an intensive, individualized form of transcranial magnetic stimulation. In the study, remission typically occurred within days an
17h
How did we get fertility so wrong? | Mona Chalabi
When it comes to making a baby, we know it takes two to tango. So why do the pressures of fertility often fall on only one half of the equation? In this video, data journalist Mona Chalabi examines some of the big misconceptions around fertility, shares significant blind spots in the data, and reveals why we need more research on sperm. Want to hear more from Mona? Check out her podcast Am I Norma
18h
Male and female guinea baboons equally successful as leaders
The sun rises over the Senegalese savannah. The Guinea baboons have spent the night on their sleeping trees and set off together to forage. In order to depart simultaneously as a group and roam together during the day, the animals have to coordinate well. Researchers have studied which animals lead the group and how they decide when and in which direction to set off. They observed Guinea baboons (
18h
Writing throughout human history
Humans have been writing stuff down, and when that happened exactly in their history…we really don't care here to say, What I have to say here is that there is an impression in human beings that what they imagine, is what seems to be happening, and not that something else than what they can imagine seems to be happening, and that they can imagine how that is for the specific occasion. Let's try
18h
What It Takes to Beat a Pro Racer | Street Outlaws: No Prep Kings
Stream Full Episodes of Street Outlaws: No Prep Kings on discovery+ ► https://go.discovery.com/tv-shows/street-outlaws-no-prep-kings #StreetOutlawsNoPrepKings #StreetRacing #Discovery About Street Outlaws: No Prep Kings: Street racers battle at rough, untested tracks across the country and earn points depending on how they perform. Whoever has the most points at the end is crowned the true No Pre
18h
Simple blood test predicts recovery time after hip replacement
Clues from a blood sample can predict how quickly patients who have had hip-replacement surgery will make a full recovery, according to a new study. Researchers hope the blood test will provide insights into things patients can do before and after surgery, such as adhering to a special diet or exercise routine, that may help them regain full mobility. The findings may also help clinicians more ac
18h
Satellites pinpoint communities at risk of permafrost thaw
Thawing permafrost in the Arctic is already unleashing methane and carbon dioxide to the atmosphere, exacerbating global temperature rise. As well adding to the climate crisis, this ground, which has been frozen for thousands of years, is becoming unstable and causing serious issues for local communities. For the first time, data from the Copernicus Sentinel-1 and Sentinel-2 missions along with ar
19h
Corporate sustainability fails by selling more stuff
A new book punctures two of the central tenets of corporate sustainability efforts. The automotive industry is becoming electric. Packaging companies are using compostable plastic. Clothing manufacturers are embracing "vegan" and "eco-friendly" materials. By supporting these companies, we could be on track toward a bright and sustainable future. Except that we're not, argues University of Califor
19h
Mere end hver tredje psykiatriske patient bliver genindlagt i Midtjylland: "Vi er selv ikke tilfredse med nuværende kvalitet af behandlingen"
En tværregional opgørelse, som Dagens Medicin har foretaget, viser, at genindlæggelsesfrekvensen er markant større i Region Midtjylland end i de øvrige regioner. Især i Holstebro Kommune. Formand for regionens psykiatri- og socialudvalg erkender, at regionen ikke har levet op til dens ansvar. Både Lægeforeningen og SIND forklarer, at alt for mange patienter bliver udskrevet for tidligt.
19h
Adults, not children, prefer friendly looking robots
Robots are occupying an increasingly prominent place in our society. How do we deal with this, and what is it that determines whether or not we trust these robots to carry out certain tasks and assume certain responsibilities? Sari Nijssen investigated the situations in which adults and children are inclined to ascribe human characteristics to a robot, and what consequences this has for our behavi
19h
Type 2-diabetes forsvinder i ét ud af 20 tilfælde
Et stort studie fra Skotland viser, at for hver gang 20 personer har fået en diagnose med type 2-diabetes, forsvinder sygdommen igen i ét af tilfældene. Der er behov for at finde ud af, hvad der får sygdommen til at forsvinde igen, siger forsker.
19h
Brain Stimulation for Cognitive Control
A newly published study presents a proof-of-concept for using deep brain stimulation controlled with artificial intelligence (AI) in a closed-loop system to enhance cognitive control, suggesting it might be effective for a number of mental illnesses. That's a lot to unpack, so let's go back to the beginning. The most fundamental necessary to understand what is going on here is that your brain is
20h
This personality type knowingly shares fake news
New research identifies a specific personality type that is not only more likely to share misinformation, but also undeterred from sharing it even after being warned it might be false. Although warning labels on content have proven to dissuade many people from sharing so-called "fake news," that's not true for all. The study, published in the Journal of Experimental Psychology: General , showed p
20h
Sustainable forest management discourses challenge traditional 'wood mining' in Russia
With 20% of the world's forests, Russia has global forest-related potential in bioeconomy development, biodiversity conservation and climate change mitigation. However, unsustainable forest management based on wood mining—vast clear-cut harvesting in wild forests—leads to forest degradation and reduces this potential. Published in a special issue of Ambio, "Global Forest Environmental Frontier," a
20h
Magnitude and timing of resource pulses interact to affect horseweed invasion
Erigeron canadensis (horseweed) is a serious invader in disturbed habitats and agricultural fields. It may experience nutrient pulses of different magnitudes and timings due to a variety of disturbances arising from human activities and fertilizer application on target crops. However, to date, little is known about how variations in the magnitude and timing of nutrient pluses affect E. canadensis
20h
Bönplantans rötter kan lagra energi
Genom att vattna bönfrön med en lösning som innehåller oligomerer, har forskare visat att bönplantans rötter blir elektrisk ledande och att de även kan lagra energi. Resultatet har stor betydelse inte bara för utvecklingen av hållbar energilagring utan även för utvecklingen av nya biohybridsystem, exempelvis funktionella material och kompositer. De elektroniska rötterna bidrar också starkt till u
20h
Daily briefing: Pfizer's COVID pill looks promising
Nature, Published online: 08 November 2021; doi:10.1038/d41586-021-03379-5 Pfizer antiviral cut the risk of hospitalization or death by 89% for vulnerable people newly diagnosed with COVID-19. Plus, what sponges can tell us about the nervous system, and scientists judge the COP pledges so far.
22h
Despite a Surge in Funding, Public Health's Brain Drain Persists
In California, public health nurses, microbiologists, epidemiologists, and health officers who fend off infectious diseases like tuberculosis and HIV, inspect restaurants, and work to keep communities healthy are leaving the field. The brain drain is sapping community health oversight in ways big and small.
22h
Co-evolution based machine-learning for predicting functional interactions between human genes
Nature Communications, Published online: 09 November 2021; doi:10.1038/s41467-021-26792-w With the rise in number of eukaryotic species being fully sequenced, large scale phylogenetic profiling can give insights on gene function, Here, the authors describe a machine-learning approach that integrates co-evolution across eukaryotic clades to predict gene function and functional interactions among h
22h
Biomimetic apposition compound eye fabricated using microfluidic-assisted 3D printing
Nature Communications, Published online: 09 November 2021; doi:10.1038/s41467-021-26606-z Insect-like biomimetic compound eyes have many technological applications. Here, the authors present a facile fabrication scheme involving microfluidics assisted 3D printing that permits to completely separate design, optimization and construction of optical and sensor components.
22h
Air-conditioning and the adaptation cooling deficit in emerging economies
Nature Communications, Published online: 09 November 2021; doi:10.1038/s41467-021-26592-2 Adaptation to heat stress through the use of air conditioners has received increasing attention. Here the authors show that income and humidity adjusted temperature are common determinants for adopting air conditioning, but their relative contribution varies in relation to household characteristics.
22h
Mid-lateral cerebellar complex spikes encode multiple independent reward-related signals during reinforcement learning
Nature Communications, Published online: 09 November 2021; doi:10.1038/s41467-021-26338-0 The role of complex spikes in reinforcement learning is still unclear. Here, the authors show that complex spikes carry multiple context based, cell type specific and learning dependent signals that are independent of changes in any motor kinematics and unlikely to instruct the concurrent simple spike activi
22h
Single-molecule imaging with cell-derived nanovesicles reveals early binding dynamics at a cyclic nucleotide-gated ion channel
Nature Communications, Published online: 09 November 2021; doi:10.1038/s41467-021-26816-5 Here the authors use nanovesicles, microfluidics and single-molecule methods to observe individual ligand binding events that stimulate activation of CNG ion channels. They find that binding is followed by a conformational change of either independent or weakly cooperative binding domains.
22h
rRNA biogenesis regulates mouse 2C-like state by 3D structure reorganization of peri-nucleolar heterochromatin
Nature Communications, Published online: 09 November 2021; doi:10.1038/s41467-021-26576-2 The role of the nucleolus in cell fate is not well known. Here the authors show nucleolar integrity maintained by rRNA-mediated liquid-liquid phase separation and 3D chromatin structure of perinucleolar heterochromatin regulates the fate transition of mouse embryonic stem cells to 2 cell-stage embryo-like ce
22h
Virgin Galactic has sold 100 more space tickets
Virgin Galactic has sold around 100 tickets since flying its founder Richard Branson to space last summer, with commercial services expected to begin by the end of 2022, the company said in its financial results Monday.
23h
SpaceX capsule streaks across the sky before splashing down in the Gulf of Mexico – video
Four astronauts strapped inside a SpaceX Crew Dragon capsule have splashed down safely in the Gulf of Mexico off the Florida coast, ending a six-month Nasa mission onboard the International Space Station and a day-long flight home. The Dragon vehicle, called Endeavour, parachuted into the sea as planned just after 10.30pm EST on Monday, after a fiery re-entry descent through Earth's atmosphere br
23h
New gold rush fuels Amazon destruction
Standing over the gaping pit in the middle of his small farm, Brazilian wildcat miner Antonio Silva struggles to explain why he joined the new gold rush sweeping the Amazon.
23h
Lack of massive black holes in telescope data is caused by bias
Our telescopes have never detected a black hole more massive than 20 times the mass of the sun. Nevertheless, we now know of their existence as dozens of those black holes have recently been "heard" to merge via gravitational wave radiation. A team of astronomers led by Peter Jonker (SRON/Radboud) has now discovered that these seemingly disparate results can be explained by biases against massive
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Cop26: solutions from the frontline – podcast
The Science Weekly podcast is in Glasgow, where we are bringing listeners daily episodes from Cop26. Each morning you will hear from one of the Guardian's award-winning environment team. Today, Science Weekly host Madeleine Finlay and Guardian reporter Nina Lakhani attend the People's Summit, which brings together movements from across the world to build solutions for climate change In the run-up
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Cop26: solutions from the frontline
The Science Weekly podcast is in Glasgow, where we are bringing listeners daily episodes from Cop26. Each morning you will hear from one of the Guardian's award-winning environment team. Today, Science Weekly host Madeleine Finlay and Guardian reporter Nina Lakhani attend the People's Summit, which brings together movements from across the world to build solutions for climate change. Help support
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Why nitrous oxide emissions should factor into climate change mitigation
A newly published study found that a range of agricultural soils produce nitrous oxide emissions in sufficient quantities to contribute to climate change. The researchers compared soils with various moisture content and found agricultural soils are capable of high nitrous oxide emissions across a wide range of environmental conditions.
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Man Bursts Into Flames After Being Tased by Police
A New York man is in critical condition after dousing himself with hand sanitizer and being set ablaze when a police officer used a Taser on him, Albany's Times-Union newspaper reports — a grisly incident that raises deep questions about law enforcement's wielding of high tech weaponry against the public. The bizarre encounter took place on Halloween weekend when Jason Jones, a 29-year-old man fr
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