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Of Course Kyle Rittenhouse Was Acquitted
The United States is a nation awash in firearms, and gun owners are a powerful and politically active constituency. In state after state, they have helped elect politicians who, in turn, have created a permissive legal regime for the carry and use of firearms, rules that go far beyond how courts originally understood the concept of self-defense. These laws have made it difficult to convict any gu
18h
How Facebook and Google fund global misinformation
Myanmar, March 2021. A month after the fall of the democratic government. In 2015, six of the 10 websites in Myanmar getting the most engagement on Facebook were from legitimate media, according to data from CrowdTangle, a Facebook-run tool. A year later, Facebook (which recently rebranded to Meta) offered global access to Instant Articles, a program publishers could use to monetize their content
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LATEST

Netflix's Cowboy Bebop Fails
The live-action adaptation is an overwrought performance of the beloved anime rather than a bold reimagining.
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Evidence found of genetic evolution in Europeans over past several thousand years
A team of researchers affiliated with several institutions in China has found evidence of natural selection based evolutionary changes to people living in Europe over the past two to three thousand years. In their paper published in the journal Nature Human Behavior, the group describes their comparative study of people living in the U.K. today, with those living across Europe over the past severa
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Scientists use machine learning to predict smells based on brain activity in worms
It sounds like a party trick: scientists can now look at the brain activity of a tiny worm and tell you which chemical the animal smelled a few seconds before. But the findings of a new study, led by Salk Associate Professor Sreekanth Chalasani, are more than just a novelty; they help the scientists better understand how the brain functions and integrates information.
21h
When was Jesus born?
Although millions of people celebrate the birth of Jesus Christ on Dec. 25, most scholars agree that he wasn't born on that day, or even in the year 1 A.D.
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Woman Freaks Out After Discovering an Apple Tracking Device on Her Car
An Arkansas woman found herself in a consumer tech nightmare scenario recently when she discovered that someone had put an Apple tracking device on her car — a grim example of how high tech gadgets are often coopted for surveillance and harassment . As Jonesboro, Arkansas' KAIT News reported , the unidentified woman was shocked when she turned on her iPhone in her car on the way to work and got a
20h
The Rittenhouse Trial Could Never Have Been What Americans Wanted
Updated at 3:34 p.m. ET on November 19, 2021. A jury has found Kyle Rittenhouse, the teenager who shot three men during protests in Kenosha, Wisconsin, in the summer of 2020, not guilty of the charges against him. Jurors deliberated for more than three days before delivering the verdict this afternoon, accepting his attorneys' argument that Rittenhouse was acting in self-defense. The trial was in
23h
Kamala Harris Becomes First Acting Woman President While Biden Gets Colonoscopy
Vice President Kamala Harris broke yet another barrier when she became the first woman to serve as acting president when President Joe Biden temporarily transferred power to her on Friday. The reason: Biden was having a colonoscopy. During a routine checkup at Walter Reed National Military Medical Centre, Biden had a colonoscopy during which he needed to go under anesthesia, according to White Ho
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UK's warmer, wetter weather sparks bumper year for mushrooms
Kew Gardens and RHS reporting glut of fungi as public sends in 'weird and wonderful' samples The UK is having a bumper year for mushrooms due to the warm, damp weather, says scientists, with an increase in the number of rare and unusual species identified. Members of the public have been sending in unusual samples from their gardens to experts at Kew Gardens and the Royal Horticultural Society af
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Elon Musk Brags That He Is the "Best at Humility"
Humblebrag Tesla CEO Elon Musk says he's the best — at being humble. "Don't want to brag but… I'm the best at humility," Musk tweeted today, in what most likely amounted to a cheesy dad joke — though at the same time, it may carry a shade of self-awareness. To his credit, the billionaire hasn't shied away from admitting when he was wrong, despite only doing so on the rarest of occasions. For inst
21h
Surprise! The ISS Is Still at Risk From Russian Weapon Test
In a twist absolutely no one could have seen coming, NASA says the International Space Station (ISS) is still at a heightened risk of colliding with space debris after Russia blew up a satellite with a missile earlier in the week. NASA said in a statement to the Associated Press that although "the highest threat to the station and its seven residents was in the first 24 hours" after Russia 's sur
23h
COVID Sure Looks Seasonal Now
The first part of what may be the first epidemiologic text ever written begins like so: "Whoever wishes to investigate medicine properly, should proceed thus: in the first place to consider the seasons of the year." The book is On Airs, Waters, and Places , written by Hippocrates around 400 B.C. Two and a half millennia later, the Northern Hemisphere is staring down its coming season of the year
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Let the Record Show Is an Essential Story of the AIDS Movement
For an outstanding chronicle of the early years of AIDS activism, look no further than Sarah Schulman's Let the Record Show: A Political History of ACT UP New York, 1987–1993 , which is also an exemplary model for telling a more complete story of a political movement. In writing Let the Record Show , published earlier this year, Schulman has orchestrated a people's history of ACT UP New York. Her
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Tick, Tick … Boom Is Lin-Manuel Miranda's Best Work Since Hamilton
Jonathan Larson is someone who writes like he is running out of time. That's the underlying message of "30/90," the first song in his original musical Tick, Tick … Boom and an energized ballad about the theatrical composer's worries that he hasn't accomplished enough—at the age of 30. As he hammers away at a piano, Larson notes that his idol, the composer Stephen Sondheim, contributed to his firs
5h
This scientist now believes covid started in Wuhan's wet market. Here's why.
Michael Worobey hasn't always been certain about where covid originated. During the pandemic, the University of Arizona professor has studied how the virus changes over time, and was among a group of 18 influential scientists who signed a letter in May calling for further investigation to help prove or disprove the theory that SARS-CoV-2 emerged through a possible lab accident. Now he's published
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'Gas station in space': new plan to make rocket fuel from junk in Earth's orbit
Australian company joins global effort to recycle dangerous space debris Get our free news app ; get our morning email briefing An Australian company is part of an international effort to recycle dangerous space junk into rocket fuel – in space. The orbit our planet depends on is getting clogged with debris from old spacecraft. Dead satellites and spent rocket parts are whizzing around at speeds
23h
Cryptographers Furious That "Crypto" Now Means Something Else
Oh That Crypto Not everybody was thrilled when the Staples Center in Los Angeles was renamed the "Crypto.com Arena." And that's especially true for a group of people who have had a deep connection with the term "crypto" for eons — cryptographers. "'Crypto' for decades has been used as shorthand and as a prefix for things related to cryptography," Amie Stepanovich, executive director of Silicon Fl
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Teen Hacker Arrested for Stealing $36 Million in Cryptocurrency
Big Heist A Canadian teenager was arrested this week after allegedly stealing roughly $36.5 million worth of cryptocurrency from just one individual based in the US. It's yet another instance of a cryptocurrency-related theft, showing that owning a fortune in crypto can make you a surprisingly easy target. According to police, it's "currently the biggest cryptocurrency theft reported from one per
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Tens of thousands protest in Vienna against Austria's Covid restrictions
Demonstrations come after announcement of new lockdown and plan for compulsory vaccines Coronavirus – latest updates See all our coronavirus coverage Tens of thousands of people protested in Vienna on Saturday against coronavirus restrictions a day after Austria's government announced a new lockdown and said vaccines would be made compulsory next year. Whistling, clapping, blowing horns and bangi
3h
Cargo Ship Spent Months With Captain's Corpse in Walk-in Freezer
Supply Chain Issues It's a macabre affair: in April, the captain of a cargo ship, 68-year-old Dan Sandu from Romania, passed away. Crewmates had to resort to stuffing his body into the ship's walk-in freezer, The Wall Street Journal reports , but what they didn't expect was that Sandu's body would remain in there for the next six months — with an astonishing 13 countries refusing to take care of
19h
Women Accuses Tesla of Disgusting Sexual Harassment
Daily Harassment A woman is suing Tesla after she allegedly received near daily sexual harassment while working at the company, but got no help despite reporting her issues to her supervisors and human resources. Jessica Barraza, a production associate on the Tesla Model 3, sued the electric car company on Thursday, according to The Washington Post . In her filing, she alleged disgusting and outr
22h
Your self-driving robotaxi is almost here | Aicha Evans
We've been hearing about self-driving cars for years, but autonomous vehicle entrepreneur Aicha Evans thinks we need to dream more daringly. In this exciting talk, she introduces us to robotaxis: fully autonomous, eco-friendly shuttles that would take you from place to place and take up less space on the streets than personal cars. Learn how this new technology works — and what a future where we
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Real Men Drive Electric Trucks
Photographs by Giancarlo D'Agostaro "W e brought the car to the American people. Then we built them a truck," a male voice boomed during the launch event for the Ford F-150 Lightning . As the streetlights of Dearborn, Michigan, flickered lazily behind the stage set up outside company headquarters, a giant screen showed black-and-white footage of workers at an early-20th-century Ford assembly plan
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Could We Gene Hack Ourselves to Be Blissed Out Sex Maniacs, Like Our Distant Cousins the Bonobos?
This week, we're pleased to bring you a different version of Futurism, containing stories from the horizon of hedonism. Welcome to The Science of Pleasure . In collaboration with our friends over at MEL Magazine , this week, we'll be bringing you stories from both publications about the pleasures of tomorrow, today. Bonobos are a species of primate believed to be humankind's second-closest living
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How the Build Back Better Act Could Backfire on Democrats
H ouse Democrats have passed landmark legislation to give an enormous tax cut to some of the nation's wealthiest Americans. The bill they approved—President Joe Biden's Build Back Better Act—also makes dramatic investments to tackle climate change, establishes universal pre-K, reduces the cost of prescription drugs, and substantially expands federal assistance for health and child care. But if Re
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The Anachronistic Joy of Dickinson
Emily Dickinson's life, according to the show Dickinson , had a lot more gay sex and twerking than your middle-school English class would have had you believe. And, from what we now know of the reclusive poet's life, at least half of that is true. The Apple TV+ cult hit—now in its third and final season—retells Dickinson's life by pairing a modern knowledge of her lifelong relationships with a mo
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COVID May Have Messed Up One Million Americans' Sense of Smell
One of the most well-known symptoms of COVID-19 is anosmia, or the loss of the sense of smell . Now, a new study says that more than one million Americans might have permanently lost the ability to smell due to the pandemic — suggesting that the symptom could be much more widespread than previously thought. The study, published Thursday in the journal JAMA Otolaryngology – Head & Neck Surgery , e
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NASA's Moon Orbiter Almost Crashed Into India's Moon Orbiter
Collision Avoided Even the Moon's orbit is becoming increasingly cluttered with human-made objects. Back in October, NASA's Lunar Reconnaissance Orbiter had to adjust its orbit to dodge out of the way of India's Chandrayaan-2 Orbiter, according to a recent statement by the Indian Space Research Organization (ISRO). On October 20, the two orbiters got too close for comfort near the Moon's north po
1h
Winged Gods and walking griffons: A plate with a depiction of Scythian Gods has been found in Middle Don
Expedition members of IA RAS have found a unique plate depicting winged Scythian gods surrounded by griffons during their excavations of the burial ground Devitsa V in Ostrogozhsky District of Voronezh region. This is the first case of such a finding in the Scythian barrows on Middle Don. No other items depictions of gods from the Scythian pantheon have been found in this area.
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Mosquitoes have a mutual symbiotic relationship with malaria-causing pathogen
Cornelius Vanderbilt Professor of Biological Sciences Laurence J. Zwiebel is part of a team of researchers at Vanderbilt and the Johns Hopkins Malaria Research Institute who are working to understand how Plasmodium falciparium—the pathogen that causes malaria in humans—affects the mosquitoes that spread the disease. The research was spearheaded by Ann Carr, a current visiting scholar and former po
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Can defects turn inert materials into useful, active ones?
Demonstrating that a material thought to be always chemically inert, hexagonal boron nitride (hBN), can be turned chemically active holds potential for a new class of catalysts with a wide range of applications, according to an international team of researchers.
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How Antarctic Bacteria Live on Air and Use Hydrogen as Fuel to Make Water
Humans have only recently begun to think about using hydrogen as a source of energy, but bacteria in Antarctica have been doing it for a billion years. We studied 451 different kinds of bacteria from frozen soils in East Antarctica and found most of them live by using hydrogen from the air as a fuel. Through genetic analysis, we also found these bacteria diverged from their cousins in other conti
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How a viral RNA changes shape to hijack host cells
University of Colorado Anschutz Medical Campus researchers have observed how an RNA molecule from a virus forms a complex, three-dimensional structure, and is able to change its shape to hijack host proteins. The details of this process, elusive to scientists for decades, were revealed by using cryogenic electron microscopy (cryo-EM).
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The Literary Politician
Since leaving office, Barack Obama has channeled his energy into an unexpected pursuit: building an infotainment empire. He's started a production company, made playlists for his followers, and recently published Renegades , a coffee-table book featuring a series of his conversations with Bruce Springsteen. In it, the two make the case that art can wield political power, but also reveal the tensi
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Hong Kong authorises Sinovac Covid vaccine for children aged 3 to 17
Benefits of approving age extension outweigh the risks, says secretary for food and health Coronavirus – latest updates See all our coronavirus coverage Hong Kong has approved lowering the age limit for the Covid-19 vaccine from China's Sinovac Biotech to three, down from 18 years of age. Hong Kong's secretary for food and health, Sophia Chan, said in a statement published on Saturday: "Adolescen
8h
By keeping ferroelectric 'bubbles' intact, researchers pave way for new devices
When a magician suddenly pulls a tablecloth off a table laden with plates and glasses, there is a moment of suspense as the audience wonders if the stage will soon be littered with broken glass. Until now, an analogous dilemma had faced scientists working with special electrical bubbles to create the next generation of flexible microelectronic and energy storage devices.
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Novel artificial genomic DNA can replicate and evolve outside the cell
Scientists successfully induced gene expression from a DNA and evolution through continuous replication extracellularly using cell-free materials alone for the first time. By adding the genes necessary for transcription and translation to the artificial genomic DNA, it could be possible to develop artificial cells that can grow autonomously, and it will be expected to produce efficient useful subs
20h
Two is better than one: Single-atom dimer electrocatalyst for green hydrogen production
The limited reservoir of fossils fuels and the ever-increasing threats of climate change have encouraged researchers to develop alternative technologies to produce eco-friendly fuels. Green hydrogen generated from the electrolysis of water using renewable electricity is considered a next-generation renewable energy source for the future. But in reality, the overwhelming majority of hydrogen fuel i
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A genetic change for achieving a long and healthy life
Living a long, healthy life is everyone's wish, but it is not an easy one to achieve. Many aging studies are developing strategies to increase health spans, the period of life spent with good health, without chronic diseases and disabilities. Researchers at KAIST presented new insights for improving the health span by just regulating the activity of a protein.
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The Atlantic Daily: The Unanswered Questions of the Rittenhouse Verdict
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox. A jury found Kyle Rittenhouse, the teenager who shot three people, two fatally, amid the protests over the killing of Jacob Blake in Kenosha, Wisconsin, not guilty on all counts. Given the narrow
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Net Zero/Not Zero
At the COP26 gathering last week much of the discussion related to "Net-Zero" goals. This concept derives from important physical science results highlighted in the Special Report on 1.5ºC and more thoroughly in the last IPCC report that future warming is tied to future emissions, and that warming will effectively cease only once anthropogenic CO2 emissions are balanced by anthropogenic CO2 remov
48min
Big Red Finally Brings In over $400K of Gold for Parker | Gold Rush
Stream Gold Rush on discovery+: https://www.discoveryplus.com/show/gold-rush #Discovery #GoldRush #ParkerSchnabel Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitter.com/Discovery From: Discove
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This Week's Awesome Tech Stories From Around the Web (Through November 20)
COMPUTING This New Startup Has Created a Record-Breaking 256-Qubit Quantum Computer Siobhan Roberts | MIT Technology Review "The QuEra machine is the latest leap in scaling up quantum computing to make it more powerful and capable of tackling practical problems. More qubits mean more information can be stored and processed, and researchers developing the technology have been racing to continually
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Weekend reads: An error in a PLOS journal leads to angry calls to Fauci; Jonathan Pruitt placed on leave; Cassava Sciences under SEC investigation
Before we present this week's Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured: Publisher retracts nearly 80 articles over three days PNAS retracts … Continue reading
5h
Snowbirds
Photographs by Naomi Harris I n December 1999 , Naomi Harris turned down a job offer, left her apartment in New York, and checked into the Haddon Hall Hotel, in Miami Beach. She was 26. She wanted to be a photographer. The hotel was a year-round home for some and a seasonal residence for others—snowbirds, mostly in their 80s and 90s, who came down from New England or Canada and stayed all winter.
6h
Pope Francis Is Right About My Profession
L ast weekend, Pope Francis gave my profession a gift: a thoughtful outsider's perspective on the proper role of journalists. "Your mission is to explain the world, to make it less obscure, to make those who live in it less afraid of it and look at others with greater awareness, and also with more confidence," he said, adding that, to succeed, journalists must first listen . By this, he meant far
7h
The New Pandemic Division Tearing Europe Apart
For a while, during the worst of the pandemic last year, European governments largely seemed to reach a consensus. Barring a few exceptions (such as Sweden), countries in the region locked down their economies, keeping people at home in a bid to slow the pace of infection. In time, bolstered by plentiful vaccines, the continent has seen a resumption of near-normalcy: Public-health restrictions ha
7h
Vetenskapliga livsöden och anekdoter
Den allra första Nobelprismedaljen som delades ut togs emot av Wilhelm Röntgen 1901. Han hade publicerat sin upptäckt av röntgenstrålningen i slutet av 1895, och den kom genast till användning. Bara omkring ett år efter upptäckten gjordes den första röntgenundersökningen i Sverige, vilket ledde till att läkarna kunde rädda livet på en man som blivit skjuten i huvudet. Här kan vi verkligen tala om
11h
Scientists capture humor's earliest emergence
Young children's ability to laugh and make jokes has been mapped by age for the first time using data from a new study involving nearly 700 children from birth to 4 years of age, from around the world. The findings identify the earliest age humor emerges and how it typically builds in the first years of life.
18h
Breeding plants with genes from one parent
Scientists are a step closer to breeding plants with genes from only one parent. New research led by plant biologists at UC Davis shows the underlying mechanism behind eliminating half the genome and could make for easier and more rapid breeding of crop plants with desirable traits such as disease resistance.
19h
Archaeologists discover salt workers' residences at underwater Maya site
Maya archaeologists have excavated salt kitchens where brine was boiled in clay pots over fires in pole and thatch buildings preserved in oxygen-free sediment below the sea floor in Belize. But where these salt workers lived has been elusive, leaving possible interpretations of daily or seasonal workers from the coast or even inland. This gap left nagging questions about the organization of produc
20h
A genetic change for achieving a long and healthy life?
Researchers presented new insights for improving the health span by just regulating the activity of a protein. A research group has identified a single amino acid change in the tumor suppressor protein phosphatase and tensin homolog (PTEN) that dramatically extends healthy periods while maintaining longevity.
20h
The brain uses bodily signals to regulate fear
Fear is essential for survival, but must be well regulated to avoid harmful behaviors such as panic attacks or exaggerated risk taking. Scientists have now demonstrated in mice that the brain relies on the body's feedback to regulate fear. The brain's insular cortex strongly reacts to stimuli signaling danger. However, when the body freezes in response to fear, the heartbeat slows down leading to
20h
New imaging technology may reduce need for skin biopsies
A new 'virtual histology' technology shows promise by analyzing images of suspicious-looking lesions and quickly producing a detailed, microscopic image of the skin, bypassing several standard steps typically used for diagnosis — including skin biopsy, tissue fixation, processing, sectioning and histochemical staining.
21h
Study links stress to Crohn's disease flare-ups
Researchers using mouse models found that stress hormones suppressed the innate immune system that normally protects the gut from invasive Enterobacteriaceae, a group of bacteria including E. coli which has been linked to Crohn's disease.
21h
Plumbing the depths: Defect distribution in ion-implanted SiC diodes
Introducing a vertical arrangement of n and p layers into the drift layer of semiconductors to enable bipolar operation is a way around the 'unipolar limit' problem in semiconductors. But defect generation during the fabrication of such devices is a matter of concern. Researchers have examined the depth and distribution of defects formed by aluminum ion implantation in silicon carbide bipolar diod
21h
Different kinds of marine phytoplankton respond differently to warming ocean temperatures
A team of researchers has concluded that different types of phytoplankton will react differently to increasing ocean temperatures resulting from the changing climate. An examination of how four key groups of phytoplankton will respond to ocean temperatures forecast to occur between 2080 and 2100 suggests that their growth rates and distribution patterns will likely be dissimilar, resulting in sign
21h
Food scientists create zinc index for human body
Zinc deficiency is prevalent around the world, and among children, these mineral shortfalls can lead to stunting, embryonic malformations and neurobehavioral abnormalities. Over several decades, science has improved understanding of zinc metabolism, but an accurate, comprehensive assessment tool for its physiological status within a human body has remained elusive. Until now.
21h
Study: COVID tech took a toll on work-from-home moms
It's no secret that being a work-from-home mom during the dawn of the COVID-19 pandemic was a drag. And those tech tools—video meetings and texting—designed to make remote work easier? They just added to the stress and exacerbated the mental health toll on burnt out moms trying to hold everything together.
21h
Phages kill dystentery-causing bacteria and reduce virulence in surviving bacteria
Phages are viruses that infect bacteria and can also be used to treat human infections. However, as with antibiotics, bacteria can readily evolve resistance to phage attack, highlighting a key limitation to the use of phages as therapeutics. Now, researchers from Yale University have shown that the naturally occurring phage A1-1 kills Shigella flexneri, a major cause of dysentery in sub-Saharan Af
21h
The Millennium Project: How can everyone have sufficient clean water without conflict?
As this is a futurology subreddit, I suppose many of you have heard of The Millennium Project. It's a participatory think thank (est. 1996) with the purpose of improving humanity's prospect for building better futures. They are working on a bunch of global challenges and I would like to pose the question that is their global challenge #2: How can everyone have sufficient clean water without confl
21h
Has there been much discussion or speculation around technology reaching a point where class and wealth gaps are made larger essentially by choice?
It seems as if as things like virtual reality grow and things like cybernetics become more of a reality, we are quickly heading towards a scenario where everything from jobs to social interaction are influenced by whether or not someone is willing to use such technologies… Based on some people's current reactions to everything from 5G to vaccines, it seems extremely likely that a decent sized g
21h
Olfaction: Emotional Processing & Memory Consolidation
Please correct me if I'm wrong, but my understanding of the olfactory system is that: Olfaction is closely linked to emotion and memory consolidation. Apart from the fact that the olfactory system directly projects to the limbic system, though with anosmia (loss of smell) are highly susceptible to mental disorders such as depression. Nasal breathing appears to improve memory consolidation. Olfact
21h
The Best iPads of 2021 to Stoke Your Creativity
When Steve Jobs famously said "We want to put an incredibly great computer in a book that you can carry around with you," it's hard to believe the iPad wasn't what he had in mind. Containing the processing power of a laptop in the folio-like footprint of a small book or magazine, Apple's decade-long list of iPads offers something for everyone. The gamut of available iPads includes multiple produc
21h
New Sex Toy Aims to Emulate the Experience of Having a Penis
This week, we're pleased to bring you a different version of Futurism, containing stories from the horizon of hedonism. Welcome to The Science of Pleasure . In collaboration with our friends over at MEL Magazine , this week, we'll be bringing you stories from both publications about the pleasures of tomorrow, today. Earlier this year, UK-based dominatrix and model Adreena Angela became a beta tes
21h
MediaTek Unveils Fully Loaded Flagship Mobile Processor
In most western nations, MediaTek plays second banana to Qualcomm. The best, and most powerful phones all run on Qualcomm ARM chips, but that might change soon. MediaTek has just announced its first true flagship system-on-a-chip (SoC) in years , which it's calling Dimensity 9000. It's the world's first 4nm chip from TSMC, and it has all the latest technology. Still, this isn't MediaTek's first a
21h
Powerful gene-based testing by integrating long-range chromatin interactions and knockoff genotypes [Statistics]
Gene-based tests are valuable techniques for identifying genetic factors in complex traits. Here, we propose a gene-based testing framework that incorporates data on long-range chromatin interactions, several recent technical advances for region-based tests, and leverages the knockoff framework for synthetic genotype generation for improved gene discovery. Through simulations and applications…
22h
Opening of a cryptic pocket in {beta}-lactamase increases penicillinase activity [Biophysics and Computational Biology]
Understanding the functional role of protein-excited states has important implications in protein design and drug discovery. However, because these states are difficult to find and study, it is still unclear if excited states simply result from thermal fluctuations and generally detract from function or if these states can actually enhance…
22h
Raf-like kinases and receptor-like (pseudo)kinase GHR1 are required for stomatal vapor pressure difference response [Plant Biology]
Stomatal pores close rapidly in response to low-air-humidity-induced leaf-to-air vapor pressure difference (VPD) increases, thereby reducing excessive water loss. The hydroactive signal-transduction mechanisms mediating high VPD–induced stomatal closure remain largely unknown. The kinetics of stomatal high-VPD responses were investigated by using time-resolved gas-exchange analyses of higher-order
22h
The genetic basis of the root economics spectrum in a perennial grass [Ecology]
Construction economics of plant roots exhibit predictable relationships with root growth, death, and nutrient uptake strategies. Plant taxa with inexpensively constructed roots tend to more precisely explore nutrient hotspots than do those with costly constructed roots but at the price of more frequent tissue turnover. This trade-off underlies an acquisitive…
22h
Energetic scaling in microbial growth [Environmental Sciences]
Microbial growth is a clear example of organization and structure arising in nonequilibrium conditions. Due to the complexity of the microbial metabolic network, elucidating the fundamental principles governing microbial growth remains a challenge. Here, we present a systematic analysis of microbial growth thermodynamics, leveraging an extensive dataset on energy-limited monoculture…
22h
Microbiome stability and structure is governed by host phylogeny over diet and geography in woodrats (Neotoma spp.) [Microbiology]
The microbiome is critical for host survival and fitness, but gaps remain in our understanding of how this symbiotic community is structured. Despite evidence that related hosts often harbor similar bacterial communities, it is unclear whether this pattern is due to genetic similarities between hosts or to common ecological selection…
22h
Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit [Neuroscience]
Homeostatic plasticity of intrinsic excitability goes hand in hand with homeostatic plasticity of synaptic transmission. However, the mechanisms linking the two forms of homeostatic regulation have not been identified so far. Using electrophysiological, imaging, and immunohistochemical techniques, we show here that blockade of excitatory synaptic receptors for 2 to 3…
22h
The E3 ubiquitin ligase adaptor Tango10 links the core circadian clock to neuropeptide and behavioral rhythms [Neuroscience]
Circadian transcriptional timekeepers in pacemaker neurons drive profound daily rhythms in sleep and wake. Here we reveal a molecular pathway that links core transcriptional oscillators to neuronal and behavioral rhythms. Using two independent genetic screens, we identified mutants of Transport and Golgi organization 10 (Tango10) with poor behavioral rhythmicity. Tango10…
22h
High 3He/4He in central Panama reveals a distal connection to the Galapagos plume [Earth, Atmospheric, and Planetary Sciences]
It is well established that mantle plumes are the main conduits for upwelling geochemically enriched material from Earth's deep interior. The fashion and extent to which lateral flow processes at shallow depths may disperse enriched mantle material far (>1,000 km) from vertical plume conduits, however, remain poorly constrained. Here, we…
22h
A tripartite cytolytic toxin formed by Vibrio cholerae proteins with flagellum-facilitated secretion [Microbiology]
The protein MakA was discovered as a motility-associated secreted toxin from Vibrio cholerae. Here, we show that MakA is part of a gene cluster encoding four additional proteins: MakB, MakC, MakD, and MakE. MakA, MakB, and MakE were readily detected in culture supernatants of wild-type V. cholerae, whereas secretion was…
22h
Individual vulnerability to industrial robot adoption increases support for the radical right [Political Sciences]
The increasing success of populist and radical-right parties is one of the most remarkable developments in the politics of advanced democracies. We investigate the impact of industrial robot adoption on individual voting behavior in 13 western European countries between 1999 and 2015. We argue for the importance of the distributional…
22h
PD-L1 sustains chronic, cancer cell-intrinsic responses to type I interferon, enhancing resistance to DNA damage [Cell Biology]
Programmed death ligand 1 (PD-L1), an immune-checkpoint protein expressed on cancer cells, also functions independently of the immune system. We found that PD-L1 inhibits the killing of cancer cells in response to DNA damage in an immune-independent manner by suppressing their acute response to type I interferon (IFN; IFN-I). In…
22h
Multisubstrate DNA stable isotope probing reveals guild structure of bacteria that mediate soil carbon cycling [Microbiology]
Soil microorganisms determine the fate of soil organic matter (SOM), and their activities compose a major component of the global carbon (C) cycle. We employed a multisubstrate, DNA-stable isotope probing experiment to track bacterial assimilation of C derived from distinct sources that varied in bioavailability. This approach allowed us to…
22h
The small molecule Zaractin activates ZAR1-mediated immunity in Arabidopsis [Plant Biology]
Pathogenic effector proteins use a variety of enzymatic activities to manipulate host cellular proteins and favor the infection process. However, these perturbations can be sensed by nucleotide-binding leucine-rich-repeat (NLR) proteins to activate effector-triggered immunity (ETI). Here we have identified a small molecule (Zaractin) that mimics the immune eliciting activity of…
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Photoisomerization transition state manipulation by entangled two-photon absorption [Chemistry]
We demonstrate how two-photon excitation with quantum light can influence elementary photochemical events. The azobenzene trans → cis isomerization following entangled two-photon excitation is simulated using quantum nuclear wave packet dynamics. Photon entanglement modulates the nuclear wave packets by coherently controlling the transition pathways. The photochemical transition state during passa
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Correction to Supporting Information for Ghose et al., Chemotactic movement of a polarity site enables yeast cells to find their mates [Cell Biology]
CELL BIOLOGY Correction to Supporting Information for "Chemotactic movement of a polarity site enables yeast cells to find their mates," by Debraj Ghose, Katherine Jacobs, Samuel Ramirez, Timothy Elston, and Daniel Lew, which published May 28, 2021; 10.1073/pnas.2025445118 (Proc. Natl. Acad. Sci. U.S.A. 118, e2025445118). The authors note that in…
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