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Covid antiviral pill halves hospitalisations and deaths, maker says
If approved, Merck's drug would be first simple oral medication shown to be effective against coronavirus Coronavirus – latest updates See all our coronavirus coverage The first pill to treat coronavirus could be available within months after it was found to cut hospitalisations and deaths by half. If approved, the antiviral drug would be the first simple pill shown to be effective against Covid-
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NASA Refuses to Rename Giant Homophobic Telescope
Stuck With Webb NASA has announced that it will not be changing the name of the James Webb Space Telescope despite criticism from the public, astronomers, and even NASA employees. The orbital observatory, which is expected to revolutionize astronomy by letting scientists see farther into space in greater detail than ever before, has come under fire this year due to the bigoted history of its name
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NASA Puzzled by Five Fireballs Over America in One Night
Fireball Alert NASA's Meteor Watch confirmed sightings of at least five fireballs soaring through the evening sky over the US last Friday night. In a Facebook post , the Meteor Watch noted that there were at least 80 eyewitness accounts of a massive fireball soaring over the North Carolina coast, becoming visible at around 7:40 pm. The giant space rock eventually disintegrated after covering 26 m
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The Conservatives Dreading—And Preparing for—Civil War
"Let me start big. The mission of the Claremont Institute is to save Western civilization," says Ryan Williams, the organization's president, looking at the camera, in a crisp navy suit. "We've always aimed high." A trumpet blares. America's founding documents flash across the screen. Welcome to the intellectual home of America's Trumpist right. As Donald Trump rose to power, the Claremont univer
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Why Hillary Clinton Fears the GOP's Next Moves
Editor's Note: This article is part of our coverage of The Atlantic Festival. Learn more and watch festival sessions here . Hillary Clinton can draw a straight line from her duels with conservative media and Republican politicians in the 1990s to the January 6 insurrection—and she fears worse is coming. "There's always been a kind of paranoid streak in American politics," the former secretary of
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The New Anti-comedy of Jon Stewart
It seems obvious now, in hindsight, that people expected too much from comedy in the first two decades of the new millennium—that it could make us better , make us healthier , undermine despots , change minds , enable progress , even save the republic . Those were enticing ideas, but Jon Stewart never seemed to fall for them. His job was making a comedy show, as he essentially told Tucker Carlson
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Study finds that the fine structure constant of quantum spin ice is large
Quantum electrodynamics (QED) is the fundamental quantum theory governing the behavior of charged particles and light in vacuum. The strength of the interactions in QED is quantified by the fine structure constant α, which in our universe is both immutable and eternal (α ~ 1/137). The smallness of the fine structure constant has far-reaching consequences in the physical world—it determines the num
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El Salvador Officially Starts Mining Bitcoin Using Power From an Actual Volcano
Volcano Mining El Salvador has officially begun to mine Bitcoin using the power harnessed from an honest-to-god volcano — and the so-called "volcanode" has already made 0.00599179 bitcoin, or about $269, according to a tweet by president Nayib Bukele . "We're still testing and installing, but this is officially the first Bitcoin mining from the volcanode," Bukele wrote. Relying on green geotherma
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BepiColombo spacecraft sends its first images of Mercury during flyby
European-Japanese probe swoops in to almost 200km above Sun's nearest planet, photographing its pock-marked features The European-Japanese BepiColombo spacecraft has sent back its first images of Mercury, as it swung by the solar system's innermost planet while on a mission to deliver two probes into orbit in 2025. The mission made the first of six flybys of Mercury at 11.34pm GMT on Friday, usin
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Neuralink Co-Founder Predicts That Humanity Will Get "Wrecked"
Departed Neuralink co-founder Max Hodak has a grim take on the fate of humanity: the robot uprising is inevitable, and they will leave humans in the dust. Key to his argument, which is admittedly a little hard to follow, is that AI will likely not adhere to humanity's preconceptions about political and economic models for society. "Humans are objectively bad with socialism (and on the contrary, c
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Rubio: I'm Not Sure We're Better Off Than We Were Under Trump
Editor's Note: This article is part of our coverage of The Atlantic Festival. Learn more and watch festival sessions here . Despite the whirlwind in Washington this week, Marco Rubio isn't worried—at least not for his own party. As of now, Democrats have reached a deal to stave off a government shutdown until December, but they still need to prevent another crisis: a first-ever default on the nat
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DARPA Successfully Launched an "Air-Breathing" Hypersonic Missile
Nyoom! The US Air Force and the DARPA, the military's advanced research division, successfully test flew a hypersonic missile last week. The test, in which a Hypersonic Air-breathing Weapon Concept (HAWC) was released from an aircraft before its engine switched on, sending it screaming at over five times the speed of sound, according to a DARPA announcement . DARPA says that the missile — which e
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Humans Could Definitely Live to 130, Scientists Say
According to a new study published in the Royal Society Open Science journal, humans could technically live until at least 130. The researchers also found that past a certain point, the risk of dying as a supercentenarian plateaus, and remains constant at a 50/50 chance of dying within a given year. The implication, seemingly, is that sufficiently advanced medicine could provide many people with
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Doctors, receptionists and practice teams quit after wave of hostility over GP appointments
Fears of mass exodus as abuse by patients skyrockets over blood tests, jabs and face-to-face consultations Coronavirus – latest updates See all our coronavirus coverage Senior doctors have warned that practice staff and GPs are quitting after an unprecedented and escalating wave of abuse from patients that has followed weeks of public pressure over face-to-face appointments. Practice managers, re
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Why LeBron James Shouldn't Cover for Vaccine Refusers
In most years, NBA Media Day is pretty uneventful—just an opportunity for players and teams to gather before the press and discuss their goals for the upcoming season. But unfortunately for pro basketball, the headlines after this week's interviews weren't about how likely the Milwaukee Bucks are to repeat as NBA champions, or whether LeBron James and his veteran Los Angeles Lakers team can add a
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The Icy "Glue" Holding Antarctica Together Is Starting To Fail
Glue Job A team of scientists took a closer look at what — other than the obvious factor of climate change — is causing Antarctica's ice shelves to break apart into gigantic chunks, and found that the "glue" holding it all together is in alarmingly rough shape. Apparently, Antarctica's ice shelves have a way to repair themselves when they start to split and crack apart, according to research publ
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UK might not be over the worst, scientists warn, as Covid case numbers stay high
Inoculation programme must be stepped up before the onset of winter Coronavirus – latest updates See all our coronavirus coverage Britain is heading into winter with the number of Covid cases remaining at a worryingly high level. At the same time, the nation's vaccination programme appears to have stalled. That is the bleak view of leading epidemiologists who have warned that the worst effects of
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In Netflix's Squid Game, Debt Is a Double-Edged Sword
For the chance to escape severe debt, the characters in Netflix's hugely popular survival drama Squid Game would risk anything, even death. Take the protagonist Seong Gi-hun. Unemployed, he spends his days in Seoul gambling on horse races and has signed away his organs as collateral to his creditors. His deficits, both financial and personal, hurt the people closest to him: He hasn't paid child s
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Former Jeff Bezos Space Employee: "I Really Wished He Was the Person We All Thought He Was"
Just Disappointed Alexandra Abrams, the former Head of Employee Communications at Jeff Bezos' spaceflight company, Blue Origin, says she's disappointed in Bezos for allowing a toxic culture to take hold at the company. We previously covered a Lioness open letter written by Abrams and a cohort of other current and former Blue Origin employees in which they say the company's senior leadership foste
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Blockchain Company Accidentally Gives Out $90 Million, Begs People to Give It Back
It's just another day in the Wild West of cryptocurrency markets. Users of the blockchain startup Compound got an unusual surprise. Millions of dollars worth of COMP tokens, rewards for crypto mining, were mistakenly given out Wednesday night — and the exchange is now groveling and threatening for its money back. A decentralized finance or "DeFi" protocol like Compound allows investors to trade d
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Hackers Attacked a Hospital and Allegedly Killed a Newborn Baby
A woman who gave birth at a hospital that had been brought to its knees by a ransomware hack is now suing over the death of her newborn daughter. The death appears to mark the first official casualty of a ransomware hack, in which hackers seize control of a computer network and demand payment , usually in cryptocurrency, to restore it — a crime that, clearly, can be lifethreatening when directed
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Is the Texas Abortion Law Backfiring on the People Who Pushed It Through?
O ne month ago today , abortion opponents in Texas won a major victory: The Supreme Court allowed a novel and near-total ban on abortion to go into effect, making the state the first since Roe v. Wade was decided in 1973 to effectively outlaw the procedure. The law now faces multiple challenges in the lower courts after two out-of-state men sued a Texas abortion provider; they say they plan to co
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More Than 20 Blue Origin Employees Say It's a Horrible Place to Work
While Jeff Bezos' Blue Origin is directly impeding NASA's efforts to get the first astronauts back to the Moon since 1972, the space company is facing some serious inner turmoil. An essay signed by 21 current and former employees paints a bleak picture of what it's like to work at Blue Origin, a company that the signers say is "rife with sexism" and often pushes employees to their limits. "Many o
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Anil Seth Finds Consciousness in Life's Push Against Entropy
Anil Seth wants to understand how minds work. As a neuroscientist at the University of Sussex in England, Seth has seen firsthand how neurons do what they do — but he knows that the puzzle of consciousness spills over from neuroscience into other branches of science, and even into philosophy. As he puts it near the start of his new book, Being You: A New Science of Consciousness (available Octobe
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Hyggesfritt skogsbruk vinner mark
Hyggesfritt skogsbruk är en av megatrenderna inom det globala skogsbruket. Det är hållbart, ekonomiskt fördelaktigt och ger rikare biodiversitet enligt förespråkare. Men forskare vid det svenska skogsbrukets forskningsinstitut är tveksamma till metoden. De vill inte överge kalhyggesbruket. – Svenskt skogsbruk är fantastiskt, och kalhyggen det bästa sättet att få fram virke till industrin, säger Ro
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Did Pfizer Peak Too Soon?
The Delta variant's arrival this summer delivered a blow to the nation's entire coronavirus arsenal, but its impact on the champion of last year's vaccine race—Pfizer—has been particularly humbling. Compared with Moderna's competing shot, Pfizer's vaccine seems to induce half the amount of virus-fighting antibodies , and is associated with nearly twice as many breakthrough infections , according
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Transforming America With a One-Vote Majority
The Democrats, you may have heard , are in disarray. President Joe Biden's approval ratings have sunk to new lows, and his expansive economic agenda is stalled on Capitol Hill. Opposition from progressives forced House leaders to scrap a planned vote Thursday on the president's lone bipartisan success in the Senate, a $1.2 trillion infrastructure bill. That failure, and the ensuing finger-pointin
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Flu and Covid jabs safe to be given at same time, study finds
Clinical trial on joint flu, Pfizer and AstraZeneca vaccinations reported only mild to moderate side-effects Coronavirus – latest updates See all our coronavirus coverage Flu jabs are safe to give at the same time as the Pfizer or AstraZeneca Covid vaccines, according to the first clinical trial to investigate co-administering the shots in a single appointment. While some people experienced more
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Hydroxychloroquine sales spiked almost 100% in Australia at start of Covid pandemic, study finds
There was also a rise in prescriptions for ivermectin being filled, despite no evidence either drug is effective against the virus The amount of hydroxychloroquine and ivermectin dispensed from Australian pharmacies increased significantly in 2020 as the Covid pandemic took hold, according to new research. Analysis of six publicly subsidised drugs – including hydroxychloroquine, ivermectin, corti
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New AR Glasses Are for Streaming Video and Ignoring the Real World
Picture-in-Picture The augmented reality developer Nreal just announced a new, cheaper model of its AR glasses, which it's calling the Nreal Air. But unlike previous Nreal models, and just about every other mixed reality headset out there, the new system will focus solely on streaming video or displaying other media. As The Verge notes , the Nreal Air will be missing the components, like outward-
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Jeff Bezos's space flight firm 'rife with sexism', employees' letter claims
Open letter by current and ex-staffers alleges 'consistently inappropriate' behaviour by Blue Origin leaders A group of current and former employees at Blue Origin, the space flight company owned by the Amazon founder, Jeff Bezos , has accused the business of operating a work environment that is "rife with sexism" and prefers "breakneck speed" to safety. An open letter written by Alexandra Abrams
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Linker histones tune the length and shape of chromosomes
Human life hinges on the ability of our cells to cram six feet of DNA into a 10-micron nucleus—equivalent to fitting a mile of string inside one green pea. But stuffing genes into cramped quarters is only half the battle. The DNA must also remain organized, carefully coiled into loops that ensure the information remains readily accessible and not a tangled mess.
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'You can't sue your way to the moon': Elon Musk intensifies Bezos space feud
SpaceX founder, who in April won a contract from Nasa, took a jab at Jeff Bezos's Blue Origin for suing when it lost out on deal Elon Musk intensified the feud over lawsuits and rocket sizes with space rival Jeff Bezos this week, kicking off the latest round in the billionaire battle over humanity's return to the moon . The SpaceX founder, who in April won a contract from Nasa to build the next-g
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Optically generated quantum fluids of light reveal exotic matter-wave states in condensed matter physics
Researchers from Skoltech and the University of Southampton, U.K., have used all-optical methods to create an artificial lattice whose nodes house polaritons—quasiparticles that are half-light and half-matter excitations in semiconductors. This so-called Lieb lattice, which usually does not occur in nature, enabled the team to demonstrate breakthrough results important for condensed matter physics
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NASA's Mars Helicopter Is In Trouble
Flight Anomaly NASA's Ingenuity Mars helicopter had to delay its 14th flight due to an "anomaly" with its flight-control motors. The flight was initially scheduled for September 18, according to a Tuesday update by Jaakko Karras, deputy operations lead for the mission at NASA's Jet Propulsion Lab. Ingenuity was meant to hover at 16 feet while spinning its blades at 2,700 revolutions per minute. A
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Where Is My Mother's Safety Net?
M y dad didn't believe my mom when she announced that she was leaving him. Desperate, after years spent begging him to accept treatment for a worsening mental illness, she threatened to move out if he didn't comply with his doctor's recommendations. "Where will you go?" he asked. A former stay-at-home parent of five grown children, all just beginning their careers around the country, my mom had n
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Blue Origin Employees Say They Don't Think Its Rocket Is Safe, Wouldn't Ride In It
Hard Pass A small cohort of current and former employees of Blue Origin, Jeff Bezos's spaceflight company, recently penned an article questioning the company's commitment to safety. We wrote yesterday about the employees' claims that Blue Origin harbors a shockingly sexist work culture. Another alarming takeaway from the letter , though, comes from a completely different direction, claiming that
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Big Business Is Bankrolling an Effort to Kill the Democratic Climate Bill
Four years ago, when President Donald Trump announced that he would take the United States out of the Paris Agreement , the world's largest companies leapt into action. Tim Cook, Apple's CEO, personally beseeched Trump to remain in the pact. Bob Iger, Disney's chief executive, resigned from a White House advisory council in protest. Goldman Sachs's CEO, Lloyd Blankfein, sent his first-ever tweet
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A novel method for installing sulfur into complex molecules
A group of highly reactive compounds called persulfides have provoked great curiosity among biochemists, because of their role in nature, and how they interact with proteins to change their structure and function, affecting health, aging and disease processes.
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Check Out This Awesome Drone Footage From Inside a Hurricane
Eye of the Hurricane The National Oceanic and Atmospheric Administration (NOAA) has released dramatic footage from inside a hurricane recorded by a "Saildrone," a wind-powered and uncrewed boat developed by a company of the same name. The daredevil watercraft is equipped with a "hurricane wing," allowing it to take a huge battering and survive Hurricane Sam's 50-foot waves and winds of over 120 m
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Inspired by photosynthesis, scientists double reaction quantum efficiency
Drawing on inspiration from photosynthesis and the way it can achieve high efficiency in plants, Regents Professors Tom Moore and Ana Moore in Arizona State University's School of Molecular Sciences and their groups, together with colleagues from the Department of Chemistry at Princeton University (including Professors Gregory Scholes and Robert Knowles), have introduced a bioinspired catalyst tha
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How flawed diamonds 'lead' to flawless quantum networks
The color in a diamond comes from a defect, or "vacancy," where there is a missing carbon atom in the crystal lattice. Vacancies have long been of interest to electronics researchers because they can be used as 'quantum nodes' or points that make up a quantum network for the transfer of data. One of the ways of introducing a defect into a diamond is by implanting it with other elements, like nitro
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Grimes Spotted Reading Karl Marx After Breaking Up With Elon Musk
Rebound Guy Just a week after breaking up with SpaceX and Tesla CEO Elon Musk, acclaimed musician Claire "Grimes" Boucher has been spotted with a new guy. The lucky fellow? German economist Karl Marx, best known as one of the key thinkers behind communism during the mid-1800s. In shots published by Page Six , in fact, Grimes can be seen leafing through Marx's influential volume " The Communist Ma
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Cake was my first love – it sees me through life's highs and lows
There should be no guilt with cake, only romance – in the making, the display, the history… and, of course, the eating The Great British Bake Off is back! Sales of baking utensils skyrocket when the amateur baking show is on. It appears we're all cake mad. But I've always been mad as a box of doughnuts for cake, long before the GBBO started. In fact, it's one of my loves – not one of my vices. Cak
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The truth about artificial intelligence? It isn't that honest | John Naughton
Tests of natural language processing models show that the bigger they are, the bigger liars they are. Should we be worried? We are, as the critic George Steiner observed, "language animals". Perhaps that's why we are fascinated by other creatures that appear to have language – dolphins, whales, apes, birds and so on. In her fascinating book, Atlas of AI , Kate Crawford relates how, at the end of
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Jeff Bezos Is Being Knocked Back Down to Earth
On the night he went to space, Jeff Bezos threw a party for his employees. The hotel restaurant in Van Horn, a town in West Texas not far from the launch site, was thrumming. Inside, someone had cut into the frosted Blue of Blue Origin on a big vanilla sheet cake. Outside, a live band jammed beneath a tent skimmed with café lights. Everyone was a little buzzed and a lot relieved. They had just la
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Company Claims Pill Cuts Risk of Dying of COVID-19 in Half
Pharmaceutical company Merck claims its new COVID-19 pill, called molnupiravir, can reduce the risk of hospitalization and even death from the coronavirus by half, according to newly announced Phase III clinical trial results. The company is now applying for Emergency Use Authorization from the US Food and Drug Administration. It's a promising development for new treatments against severe cases o
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Coronavirus treatments: the potential 'game-changers' in development
After positive clinical trials for antiviral drug Molnupiravir, it joins other medicines that have shown promise Coronavirus – latest updates See all our coronavirus coverage The first clinical trial results showing a positive effect for a pill that can be taken at home has been hailed as a potential gamechanger that could provide a new way to protect the most vulnerable people from the worst eff
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Book Review: The Mirage of a Town Without Cellphones
In "The Quiet Zone," Stephen Kurczy investigates a West Virginia town largely cut off from modern technology, and the eccentric groups who live there. Green Bank, Kurczy writes, might seem like a modern-day Walden, but what he finds is much louder and more similar to the outside world than he expected.
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Employers Have Been Offering the Wrong Office Amenities
Before you read any further, take a long, slow, deep breath. Congratulations! If you're sitting in a typical American home, office building, or school, about 3 percent of the air you breathed in recently came out of the lungs of the people in the room with you right now. Breathing in one another's air is kind of nasty when you think about it. We would never drink from the same cup of water that e
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Universities Are Shunning Their Responsibility to Democracy
I was born in Canada , and my sense of national identity, like that of many Canadians, was formed in direct relation—perhaps in opposition—to the great colossus to the south. We were a country that aspired not to the lofty abstractions of "life, liberty, and the pursuit of happiness" but to the more prosaic benefits of "peace, order, and good government." I have always been proud of Canada's basi
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Gene editing will just perpetuate disastrous factory farming | Letters
Instead of trying to cosh nature into submission, our farmers should be improving the health of the soil and the diversity of their crops and animals A quotation leapt to mind when reading " Gene editing 'would allow us to create hardier farm breeds ' (News): "For every complex problem there is an answer that is clear, simple, and wrong" (HL Mencken). Application of magic bullet "solutions" has go
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Now Explain What the Problem Is
Academics like me love to describe things as "problematic." But what do we mean? We're not saying that the thing in question is unsolvable or even difficult. We're saying—or implying—that it is objectionable in some way, that it rests uneasily with our prior moral or political commitments. For instance, when I described applying Ancient Greek free-speech ideals to social media as "problematic" in
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The Power of Artistic Exile
The filmmaker and polymath Melvin Van Peebles died last week at the age of 89 at his home in New York. He is best known as the auteur behind the first hit blaxploitation film, Sweet Sweetback's Baadasssss Song (1971), but he was an artist of great breadth and versatility: sculptor; poet; painter; composer and, with Gil Scott-Heron, progenitor of rap and hip-hop; playwright; gifted novelist. I wou
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Researchers suggest a way to achieve net-zero emission plastics
A team of researchers with members affiliated with institutions in Germany, Switzerland and the U.S. has created a model that they claim could be used to achieve net-zero-emission plastics by 2050. In their paper published in the journal Science, the group outlines their model and requirements for implementation.
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Schools Need to Undo the Damage of Pods
For millions of Americans, the pandemic meant one simple thing: not interacting with nearly as many people as they had before the pandemic. Amid restrictions on large gatherings, a dramatic shift to small, sheltered groups—"pods"—took place, especially among school-age kids and their families. Researchers estimate that 3 million students spent time learning in these pods over the past year. I wit
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Photos: Lava Reaches the Sea on the Island of La Palma
Lava flowing from Cumbre Vieja, an erupting volcano on the Spanish island of La Palma, reached the sea last night, spreading outward and expanding the area of the island by several hundred acres. Residents who had not already evacuated were told to shelter indoors to avoid any potential poisonous gases that might be formed as the lava interacts with seawater. Cumbre Vieja has been erupting since
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The Atlantic Daily: Biden Is Playing the Long Game
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox. Stefani Reynolds / Bloomberg / Getty Democrats, including President Joe Biden himself , are scrambling to get the party united behind a pair of massive spending bills that effectively encompass th
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Spin polarization induced by shear flow
Chinese researchers recently discovered a new effect that can generate spin-polarization in fluid. The new effect, which is called "shear-induced polarization (SIP)," predicts that shear flow can induce polarization in the momentum space.
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Nasa launches latest Landsat 9 to monitor Earth's surface
Satellite will capture agricultural productivity, forest health, water quality, coral reefs and glaciers Nasa has launched the latest mission in a 50-year unbroken line of satellites that monitor the Earth's surface. Landsat 9 lifted off atop a United Launch Alliance Atlas V rocket from Vandenberg's space launch complex 3E at 19.12 BST (14.12 EDT) on 27 September. Continue reading…
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The relationship sabotage scale: quantifying why we undermine ourselves in love
Developed over the course of five studies, the relationship sabotage scale is designed to give analytical rigour to a term more common in pop culture Do you feel constantly criticised by your partner? Do you sometimes check their social media profiles? Will you admit to them if you know you're wrong about something? If you strongly agree or disagree with some of these statements, you might find y
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Rules and advice don't slow the spread of the virus – human behaviour does | David Spiegelhalter and Anthony Masters
Surveys can help us understand how the pandemic is influenced by our choices Recent queues for fuel have shown the consequences of abrupt changes in behaviour. Almost as sudden were the changes around the first lockdown in March 2020, when close meetings between people plummeted by about three-quarters. We know this through the CoMix contact survey from the London School of Hygiene & Tropical Medi
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The Atlantic Daily: Five Podcasts for the Weekend
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox. Fall is here, and the air is getting crisp, which means it's the perfect time to snuggle up and press play on a new work of audio storytelling. I asked writers and editors from around our newsroom
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A non-invasive way to image Wigner crystals directly
A team of researchers at the University of California at Berkeley, working with a group at Lawrence Berkeley National Laboratory, has developed a non-invasive way to image Wigner crystals directly. In their paper published in the journal Nature, the group describes their approach and explain how it could be used to advance research regarding Wigner crystal states. Carmen Rubio-Verdú with Columbia
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Seismic forensics and its importance for early warning
The scientific description of the catastrophic rockslide of February 7, 2021, in India's Dhauli Ganga Valley reads like a forensic report. A rockslide and the subsequent flood had killed at least 100 people and destroyed two hydroelectric power plants. In the scientific journal Science, researchers from the GFZ German Research Center for Geosciences (GFZ) together with colleagues from the National
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Toxic algae blooms are getting worse, but oversight is lacking
Poisonous algae blooms are becoming more common in the US, threatening water supplies and public health. But so far, there are few state or federal guidelines, and local water managers could use some help, a UConn-led team of researchers reports in the September 30 issue of Nature Sustainability.
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Oxford Covid biotech firm makes stellar debut on London stock market
Shares of Oxford Nanopore close up 44%, giving co-founder paper fortune of £63m See all our coronavirus coverage Oxford Nanopore, whose DNA sequencing technology has been essential in tracking Covid-19 variants globally, has made a stellar stock market debut in London. A rise in its share price of as much as 47% has left the firm valued at almost £5bn. The flotation of the Oxford University spin-
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New microscopy technique makes deep in vivo brain imaging possible
A pioneering technique developed by the Prevedel Group at EMBL allows neuroscientists to observe live neurons deep inside the brain – or any other cell hidden within an opaque tissue. The technique is based on two state-of-the-art microscopy methods, three-photon microscopy and adaptive optics. The paper reporting on this advancement was published on 30th September 2021 in Nature Methods.
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The 'Magical Episode 4' Theory
What feels like eons ago, a friend asked for my advice on an important subject: He was trying to decide whether to start Friday Night Lights or Breaking Bad , both of which had recently become available on Netflix. Specifically, he wanted to know how many episodes he should watch of each to see which would hook him faster. My mind short-circuited. Although both are modern classics, the two series
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Primordial 'hyper-eye' discovered
An international research team has found an eye system in trilobites of the suborder Phacopina from the Devonian (390 million years ago) that is unique in the animal kingdom: each of the about 200 lenses of a hyper-facet eye spans a group of six normal compound-eye-facets, forming a compound eye itself. In addition to the hyper-facetted eyes, the researchers, led by zoologist Dr. Brigitte Schoenem
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The Books Briefing: The Essential Qualities of a Book
What is a book? Is it simply the text we read, whether on bound pages or on a screen? Or is it a tangible object, something held with human hands and made richer by the way we physically interact with it? These are questions that Atlantic writers have been considering for at least a decade, and they don't have easy, definitive answers. Recently, the Atlantic contributing writer Ian Bogost made th
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Covid: scientists warn UK may have worst to come; Israel tightens vaccine passport rules – as it happened
Fears the indoor socialising will spread virus in UK ; Israel says people only eligible for green pass if they have received a booster jab . This live blog has closed – for the latest on the global Covid situation, please see our dedicated page UK might not be over the worst, scientists warn New Zealand widens Covid lockdown as Delta spreads UK to slash international travel 'red list' to just nin
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What you need to know about US vaccine proof on your phone
We're keeping track of the covid vaccine apps rolling out in the US and some of the ways people can now prove they're vaccinated. But there's a lot of conflicting and confusing information, and a lot of developers are vying to provide the go-to solution. Here, we've gathered answers to some common questions. The basics What's a digital vaccine credential? Is it the same as a vaccine passport? Dig
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New ultra-resistant and self-repairing concrete materials
A team from the Universitat Politècnica de València (UPV) and the Politecnico di Milano has designed new ultra-resistant and self-repairing concrete materials. They have 30% more durability compared to conventional high-performance concrete in cracking situations. In the event of a crack, it is able to repair itself automatically thanks to the application of self-repairing techniques.
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Learning is more effective when active
Engaging students through interactive activities, discussions, feedback and AI-enhanced technologies resulted in improved academic performance compared to traditional lectures, lessons or readings, faculty concluded after collecting research into active learning. The research also found that effective active learning methods use not only hands-on and minds-on approaches, but also hearts-on, provid
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Marine heatwaves could wipe out an extra six per cent of a country's fish catches, costing millions their jobs
Extremely hot years will wipe out hundreds of thousands of tons of fish available for catch in a country's waters in this century, on top of projected decreases to fish stocks from long-term climate change, a new study predicts. Modelling a worst-case scenario where no action is taken to mitigate greenhouse gas emissions they projected a six per cent drop in the amount of potential catches per yea
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Our Aching Brains
COVID-19 has killed more than 4 million people around the globe and has sickened many millions more. The neurological toll on those of us continuing to live through the pandemic may stretch years or decades into the uncertain future.
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How to Rekindle a Long-Distance Friendship
Each installment of " The Friendship Files " features a conversation between The Atlantic 's Julie Beck and two or more friends, exploring the history and significance of their relationship. This week she talks with a group of men who found connection during the pandemic's early, isolated days. Spread out around the country, they had fallen out of touch, but the distance didn't matter so much whe
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Directly into the brain: A 3D multifunctional and flexible neural interface
Although measuring the electrical activity of neurons is useful in many disciplines, making durable neural interfacing brain chip implants with negligible adverse effects has proven challenging. Now, scientists have developed a flexible multifunctional neural interface that can not only register local brain activity in real time, but also deliver a steady flow of drugs through innovative microflui
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New laser meets demanding requirements for driving cutting-edge attosecond light sources
Researchers have combined a fiber-laser system with recent advancements in multi-pass cells to create a laser with a unique combination of few-cycle pulses at high average power, pulse energy and repetition rate and with stable carrier envelope phase (CEP) operation. These characteristics make the new laser ideal for driving next generation attosecond sources, such as those at the Extreme Light In
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New research shows learning is more effective when active
Engaging students through interactive activities, discussions, feedback and AI-enhanced technologies resulted in improved academic performance compared to traditional lectures, lessons or readings, faculty from Carnegie Mellon University's Human-Computer Interaction Institute concluded after collecting research into active learning.
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Gene therapy can restore vision after stroke
Vision loss can be a side effect from stroke. Neurons don't regenerate, and stem cell therapy is costly, difficult, and chancy. Researchers have figured out a way to use gene therapy to recover lost vision after a stroke in a mouse model.
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Earth is dimming due to climate change
Researchers used decades of measurements of earthshine — the light reflected from Earth that illuminates the surface of the Moon to find that there has been a significant drop in Earth's reflectance over the past two decades. The Earth is now reflecting about half a watt less light per square meter than it was 20 years ago, with most of the drop occurring in the last three years.
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Is your machine learning training set biased? How to develop new drugs based on merged datasets
Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions. In a recent paper, researchers at GlaxoSmithKline (GSK) and the Cambridge Crystallographic Data Centre (CCDC) combined their proprietary (GSK) and published (CCDC) datasets to better train machine learning (ML) models to predict stable polymorphs to use in new drug candidates.
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'Time machine' reverses pancreatic cancer progression
What makes pancreatic cancer so deadly is its covert and quick spread. Now, a "time machine" has shown a way to reverse the course of cancer before it spreads throughout the pancreas. "These findings open up the possibility of designing a new gene therapy or drug because now we can convert cancerous cells back into their normal state," says Bumsoo Han, a professor of mechanical engineering at Pur
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A 3D multifunctional and flexible neural interface
Being able to measure the electrical activity of the brain has helped us gain a much better understanding of the brain's processes, functions, and diseases over the past decades. So far, much of this activity has been measured via electrodes placed on the scalp (through electroencephalography (EEG)); however, being able to acquire signals directly from inside the brain itself (through neural inter
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The End of Bias by Jessica Nordell review – how to remove your blinkers
This thoughtful case for mounting a lifelong challenge to our own assumptions focuses on unconscious bias – but leaves overt prejudice largely unexamined We often think of bias as a problem that other people have. It's harder to find someone willing to admit to it in themselves. That was what struck me reading American journalist Jessica Nordell's thoughtful book, The End of Bias, which I picked
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Eliminating microplastics on farmland
In many countries, farmers and gardeners use mulch films to increase their crop yields. The films are often made of polyethylene and can be used to control weed growth, soil temperature and water consumption. Unfortunately the petroleum-based material is not biodegradable. Consequently, the film residues must be collected at the end of the season with considerable effort or they will pollute the f
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Reading Between the Lines of the New Biden Impression on SNL
Saturday Night Live began its 47th season with a brand-new cast member staring down the camera lens, a pointed announcement that the show is looking to stay ahead of the curve. That actor was James Austin Johnson, a comedian who gained a Twitter following for his short, surreal impressions, most famously of Donald Trump, during which he rambled through the streets while delivering strange soliloq
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Sir Antony Hewish obituary
Radio astronomer who won the Nobel prize for physics for his role in the discovery of pulsars In 1967, a team led by the radio astronomer Antony Hewish, who has died aged 97, discovered pulsars, rapidly pulsating radio sources that turned out to be due to rotating, magnetised neutron stars, the ultra-dense collapsed remnants of massive stars. This was one of the most exciting astronomical events o
33min
With Bitcoin IRA, It's Easy to Use Crypto to Invest for the Future
It's the most basic financial advice there is, but it bears repeating: it's always a good idea to save up for retirement . If you were lucky enough to be an early adopter in Bitcoin, you already know that it presented a great opportunity to build up a decent nest egg. But using bitcoins or other cryptocurrencies to save up for retirement isn't exactly traditional financial planning. Not, that is,
53min
The Music of Proteins Is Made Audible Through a Computer Program That Learns From Chopin
With the right computer program, proteins become pleasant music. There are many surprising analogies between proteins , the basic building blocks of life, and musical notation. These analogies can be used not only to help advance research, but also to make the complexity of proteins accessible to the public. We're computational biologists who believe that hearing the sound of life at the molecula
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This Infrared Sauna Blanket Helps Fight Seasonal Affective Disorder
Thanks to Seasonal Affective Disorder, better known as SAD, winter can be a pretty trying time for most people. Psychology Today reports SAD affects 10-million Americans with another 10-to-20 percent of people suffering from a milder form of the disorder. Compound that with the limitations set by the pandemic, and winter can truly feel like a never-ending hell. However, one of the best ways to co
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Jim Townsley obituary
My father, Jim Townsley, who has died aged 85, was a gentle, generous and thoughtful man who spent his working life as an industrial chemist. In retirement, his aptitude for listening, understanding and supporting the emotional needs of others found expression through voluntary work as a trained counsellor. Born in Ilford, east London, to Jim Sr, a post office worker, and Gertrude (nee Knight), a
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Put Microsoft Excel At Your Fingertips With 40% Off These Training Bundles
Data is everywhere , and increasingly central to our lives. You can put it at your fingertips with these courses from our VIP Sale, 40% off with code VIP40 for a limited time. The Premium 2021 Microsoft Excel & Data Certification Bundle Looking to use Excel for more than simple functions? This 24-course bundle touches every possible aspect, from data visualization to day-to-day automation tips to
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The Last Stop
Illustrations by Miki Lowe The poet Adam Zagajewski spent his life trying to make meaning of what he had lived through. When he was a child, his family was relocated within Poland after World War II; as a young man, he was exiled from the country altogether for writing protest poems against the country's authoritarian government. "I lost two homelands," he once said , "but I sought a third: a spa
5h
Master The Blockchain With 40% Off These FinTech Training Classes
Cryptocurrency, blockchain, and fintech have gone from buzzwords to supposedly so effective, a hamster can make a fortune . Whether or not that's true, you'll need to know what you're doing before you invest, and you can save 40% on each of these courses to learn how with the code VIP40. The Complete Cryptocurrency Investment Bundle This 5-course bundle is a perfect starting point for new investo
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Rick Hits 6 Figures in Just 3 Days! | Gold Rush
Stream Gold Rush on discovery+: https://www.discoveryplus.com/show/gold-rush #Discovery #GoldRush #Gold Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitter.com/Discovery From: Discovery
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Tony Beets Wants a $2,500,000 Bulldozer | Gold Rush: Winter's Fortune
Stream Full Episodes of Gold Rush: Winter's Fortune: discovery+ ► https://www.discoveryplus.com/show/gold-rush-winters-fortune-us #Discovery #GoldRush #GoldRushWintersFortune Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Foll
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This Week's Awesome Tech Stories From Around the Web (Through October 2)
ROBOTICS How DeepMind Is Reinventing the Robot Tom Chivers | IEEE Spectrum "Having conquered Go and protein folding, the company turns to a really hard problem. …To get to the next level, researchers are trying to fuse AI and robotics to create an intelligence that can make decisions and control a physical body in the messy, unpredictable, and unforgiving real world." NANOTECH Microscopic Metaveh
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Weekend reads: Paper mill sanctions; UT Austin suspends prof, repays grant funds; researchers in Mexico threatened with arrest
Before we present this week's Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured: Researcher leaves Wistar Institute as he retracts a Nature paper … Continue reading
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Participants needed for an online psycholinguistic experiment
Hello, Keith is my name, and I am a PhD researcher at Maynooth University`s Department of Psychology in Ireland. I am looking for people to participate in a language-related experiment that is running online, which takes approximately 15 minutes to complete. The only criteria are that participants are aged between 18-55, speak English as a first language, and have no severe visual or neurological
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Get the Brain Boost You Need With an Advanced Acetylcholine Supplement
Even if you've never heard of acetylcholine before, you've still got it on your mind … literally. That's because it's a neurotransmitter that your brain needs to perform vital functions and mental processing. And if you've been feeling at all hazy or in need of a brain boost lately, an acetylcholine supplement like Natural Stacks's Acetylcholine Brain Food might be just the thing. Research on the
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Unprecedented view of a single catalyst nanoparticle at work
A research team has been using high-intensity X-rays to observe a single catalyst nanoparticle at work. The experiment has revealed for the first time how the chemical composition of the surface of an individual nanoparticle changes under reaction conditions, making it more active. This study marks an important step towards a better understanding of real, industrial catalytic materials.
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Melting Arctic Could Release Nuclear Waste and Deadly Pathogens, Scientists Say
Sealed Away As Arctic ice melts away, it will likely raise the sea level and contribute to the devastation of ecosystems around the world. But it can also release chemical and biological hazards that had been safely sealed away. Those hazards can include ancient or undiscovered viruses and bacteria, toxic chemicals, and even nuclear waste, according to research published in the journal Nature Cli
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This Amazing Blanket Lets You Say Goodbye to Bug Repellent Once and for All
Depending on where you live, one of the worst things about hanging out on the patio at dusk is getting eaten alive by mosquitos or other insects. Of course, you could use insect repellent to ward off pesky insects, but it probably wouldn't help your cause. That's because a new study in the Journal of Insect Science has found, "many of the products … tested that were marketed as repellents do not
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Field-theoretic density estimation for biological sequence space with applications to 5' splice site diversity and aneuploidy in cancer [Biophysics and Computational Biology]
Density estimation in sequence space is a fundamental problem in machine learning that is also of great importance in computational biology. Due to the discrete nature and large dimensionality of sequence space, how best to estimate such probability distributions from a sample of observed sequences remains unclear. One common strategy…
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Earth history events shaped the evolution of uneven biodiversity across tropical moist forests [Evolution]
Far from a uniform band, the biodiversity found across Earth's tropical moist forests varies widely between the high diversity of the Neotropics and Indomalaya and the relatively lower diversity of the Afrotropics. Explanations for this variation across different regions, the "pantropical diversity disparity" (PDD), remain contentious, due to difficulty teasing…
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The impact of social isolation and changes in work patterns on ongoing thought during the first COVID-19 lockdown in the United Kingdom [Psychological and Cognitive Sciences]
The COVID-19 pandemic led to lockdowns in countries across the world, changing the lives of billions of people. The United Kingdom's first national lockdown, for example, restricted people's ability to socialize and work. The current study examined how changes to socializing and working during this lockdown impacted ongoing thought patterns…
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Surface densities prewet a near-critical membrane [Biophysics and Computational Biology]
Recent work has highlighted roles for thermodynamic phase behavior in diverse cellular processes. Proteins and nucleic acids can phase separate into three-dimensional liquid droplets in the cytoplasm and nucleus and the plasma membrane of animal cells appears tuned close to a two-dimensional liquid–liquid critical point. In some examples, cytoplasmic proteins…
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Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics [Physics]
Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of exhaled biomarkers. Here, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct-frequency comb spectroscopy (CE-DFCS) applied to breath analysis. We simultaneously detect and monitor as a function of time…
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Constitutive signal bias mediated by the human GHRHR splice variant 1 [Cell Biology]
Alternative splicing of G protein–coupled receptors has been observed, but their functions are largely unknown. Here, we report that a splice variant (SV1) of the human growth hormone–releasing hormone receptor (GHRHR) is capable of transducing biased signal. Differing only at the receptor N terminus, GHRHR predominantly activates Gs while SV1…
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Continuous measurements of volatile gases as detection of algae crop health [Agricultural Sciences]
Algae cultivation in open raceway ponds is considered the most economical method for photosynthetically producing biomass for biofuels, chemical feedstocks, and other high-value products. One of the primary challenges for open ponds is diminished biomass yields due to attack by grazers, competitors, and infectious organisms. Higher-frequency observations are needed for…
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Nanoconfinement of microvilli alters gene expression and boosts T cell activation [Biophysics and Computational Biology]
T cells sense and respond to their local environment at the nanoscale by forming small actin-rich protrusions, called microvilli, which play critical roles in signaling and antigen recognition, particularly at the interface with the antigen presenting cells. However, the mechanism by which microvilli contribute to cell signaling and activation is…
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Listeriolysin S: A bacteriocin from Listeria monocytogenes that induces membrane permeabilization in a contact-dependent manner [Microbiology]
Listeriolysin S (LLS) is a thiazole/oxazole–modified microcin (TOMM) produced by hypervirulent clones of Listeria monocytogenes. LLS targets specific gram-positive bacteria and modulates the host intestinal microbiota composition. To characterize the mechanism of LLS transfer to target bacteria and its bactericidal function, we first investigated its subcellular distribution in LLS-producer bacter
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Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2 [Neuroscience]
Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal…
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Neural mechanisms underlying the temporal control of sequential saccade planning in the frontal eye field [Neuroscience]
Sequences of saccadic eye movements are instrumental in navigating our visual environment. While neural activity has been shown to ramp up to a threshold before single saccades, the neural underpinnings of multiple saccades is unknown. To understand the neural control of saccade sequences, we recorded from the frontal eye field…
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Structural origins of Escherichia coli RNA polymerase open promoter complex stability [Biophysics and Computational Biology]
The first step in gene expression in all organisms requires opening the DNA duplex to expose one strand for templated RNA synthesis. In Escherichia coli, promoter DNA sequence fundamentally determines how fast the RNA polymerase (RNAP) forms "open" complexes (RPo), whether RPo persists for seconds or hours, and how quickly…
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Chirality-matched catalyst-controlled macrocyclization reactions [Chemistry]
Macrocycles, formally defined as compounds that contain a ring with 12 or more atoms, continue to attract great interest due to their important applications in physical, pharmacological, and environmental sciences. In syntheses of macrocyclic compounds, promoting intramolecular over intermolecular reactions in the ring-closing step is often a key challenge. Furthermore,…
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The hippocampus weaves memories into stories
A new brain imaging study shows that the hippocampus is the brain's storyteller, connecting separate, distant events into a single narrative. "Things that happen in real life don't always connect directly, but we can remember the details of each event better if they form a coherent narrative," says Brendan Cohn-Sheehy, an MD/PhD student at the University of California, Davis and first author of t
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Intel's Loihi: Cool Even If You're Not In the C-Suite
Several years ago, Intel unveiled Loihi, its first public neuromorphic research processor. The term "neuromorphic" is essentially a catch-all for any type of processor that attempts to mimic the function of the brain. Because the brain is a complex organism, different chips can be neuromorphic in different ways, depending on which aspect of the brain's design they attempt to copy. Now, Intel has
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Highly active engineered IgG3 antibodies against SARS-CoV-2 [Applied Biological Sciences]
Monoclonal antibodies (mAbs) that efficiently neutralize SARS-CoV-2 have been developed at an unprecedented speed. Notwithstanding, there is a vague understanding of the various Ab functions induced beyond antigen binding by the heavy-chain constant domain. To explore the diverse roles of Abs in SARS-CoV-2 immunity, we expressed a SARS-CoV-2 spike protein…
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Tweak amps up cancer immunotherapy by 77 fold
Researchers have developed a new nanoparticle to deliver intravenous cancer immunotherapy. Cancer immunotherapy seeks to turn "cold" tumors into "hot" tumors—those that respond to immunotherapy—by awakening and enlisting the body's own immune system. Unfortunately, few people benefit from the most common form of immunotherapy, called immune checkpoint inhibitors, and scientists are actively seeki
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What you need to know about urinary tract infections
More than half of U.S. women will experience at least one urinary tract infection (UTI) in their lifetimes, while a quarter will have a subsequent infection. Recurrent urinary tract infections are defined as two or more infections in six months or three or more in a year.
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Can food ease symptoms for people with bipolar disorders?
Can specific dietary guidelines help people living with bipolar disorders better manage their health? Maybe someday, according to a new study. Clinical trial results show that a diet designed to alter levels of specific fatty acids consumed by participants may help patients have less variability in their mood. Bipolar disorders, which affect up to 2.4% of the population, are mental health conditi
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Powerful technique details brain tumors' formidable resiliency
A team led by researchers has profiled in unprecedented detail thousands of individual cells sampled from patients' brain tumors. The findings, along with the methods developed to obtain those findings, represent a significant advance in cancer research, and ultimately may lead to better ways of detecting, monitoring and treating cancers.
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The $100-billion toll of a pig epidemic in China
Nature, Published online: 01 October 2021; doi:10.1038/d41586-021-02642-z Researchers estimate that a 2018 outbreak of African swine fever virus led to the loss of at least 38 million more animals than officially acknowledged.
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Predicting trail choices based on off-highway vehicle drivers' motivations
It's certainly easy to do, but not very useful, to stereotype outdoorsy people based on the types of recreation they choose. What kind of person takes a side-by-side vehicle up a dusty mountain road, for instance? And why? In reality, off-highway vehicle (OHV) recreation attracts a variety of people with diverse motivations for hitting the trail. And those motivations define, in part, the way they
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An open-source smartphone application to monitor drying events in river networks
Citizens can play a major role in helping scientists to understand drying river networks, by reporting drying events in rivers and streams. To do so, DRYvER has created the DRYRivERS app, which citizens can use to map drying events. The collected data will improve scientific predictions of the future impacts of climate change in these ecosystems. Moreover, DRYRivERS will raise awareness of the imp
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China's Population Projected to Fall by Half Within 30 Years
Half-Life 30 If a new study is to be believed, China could face a disastrous drop in its population within just 30 years. China's aging population and decreasing birth rate have had its government on high alarm lately, with new census data revealing an even more significant drop in new births than expected, the South China Morning Post reports . Based on that data and an overall reluctance to hav
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Save 15% Off The Drones Of Your Dreams In This Exclusive Sale
Drones are driving new science , racing in new sports leagues, and generally reminding us why we love robots. And if you want in on the drone action, we've got plenty, all for 15% off with code VIP15, Micro Drone 3.0 – Combo Pack Pictured above, this tiny drone can go up to 45 mph and offers instant video with a 720p camera. Get the Micro Drone 3.0 – Combo Pack for $110.47 (reg. $215) with code V
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Apple Watch Better At Finding Arrhythmias Than We Thought
A new analysis of data from Apple's joint heart study with Stanford has found that the Apple Watch is capable of detecting more rhythm abnormalities than we thought it could. The Apple Heart Study was designed to test the Apple Watch's ability to detect abnormal heart rhythms. Participants whose Watches notified them of potential arrhythmias received an ECG patch that would monitor their heart rh
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Just how important is the appliance of science to decisions on public policy? | Letters
Governments need to develop more citizen forums for discussing options and making choices in open dialogue with experts, writes Prof Peter Calow The answer to Philip Ball ( Should scientists run the country?, 27 September ) is that it is the process, not the people, that should run the country. Science gets things right, despite the biases of its practitioners, by requiring that it be evidence-ba
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Translucent, fingernail-sized fish is a brand new species
A fish that has been swimming in the tanks of neuroscientists for years has just been classified as a brand new species. Scientists identify and name new fish species around the globe practically every week. Some turn up in unlikely places, and others display unusual characteristics and behaviors. But it's rare for an unidentified and unnamed fish to have played an important role in scientific re
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Regulation of prefrontal patterning and connectivity by retinoic acid
Nature, Published online: 01 October 2021; doi:10.1038/s41586-021-03953-x Studies in mice, humans and macaques show that retinoic acid signalling has an important role in the development of the prefrontal cortex (PFC) in primates and may also underlie the evolutionary diversification of the PFC.
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New models may upend the origins of ocean animals
A study offers new context for a pivotal step in the evolution of life on Earth: the dramatic proliferation of animal life, hundreds of millions of years ago, in the ancient sea. The prevailing scientific theory has been that ancient waters were filled with nutrient-rich particulate matter, giving the oceans a soup-like consistency. In that scenario, early animal life—living on the seafloor and s
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New Documents Heighten Debate Over Coronavirus Origin
The dispute over the origins of the Covid-19 pandemic grew more heated this week, as a pair of papers — one a scientific study that has yet to undergo peer review, the other a leaked grant proposal — fueled speculation about the origin of a coronavirus that has killed millions of people around the world.
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Researchers shed new light on mechanical regulation of epithelial tissue homeostasis
An international team of scientists, led by Professor Ana-Sunčane Smith from the Croatian Ruđer Bošković Institute (RBI) and the Friedrich-Alexander University of Erlangen-Nürnberg in Germany, provided fresh insights on the impact of mechanical properties on the organization and growth of cell tissues. These results could contribute to a better understanding of tissue regeneration as well as in di
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Scientists Testify in Holmes Trial: Theranos Tech Was Downright Bad
Just a few short years ago, biomed startup Theranos was a media darling, and founder Elizabeth Holmes was being lauded as a self-made billionaire. All it took to topple Theranos was an article from John Carreyrou asking some tough questions about the company's Edison blood testing machine. With the company now shuttered, former CEO Holmes is facing charges for defrauding investors. According to l
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AI kan bedöma risk för återfall i bröstcancer
Med hjälp av artificiell intelligens kan cancertumörer graderas utifrån låg eller hög risk för återfall. Det gör det lättare att anpassa behandlingen till patienten. I Sverige drabbas ungefär 9 000 kvinnor varje år av bröstcancer och globalt handlar det om cirka två miljoner kvinnor. När diagnosen ställs tas vävnadsprover av tumören, som graderas av en patolog och delas in i lågrisktumör (grad 1)
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Pruning the dendritic tree
Researchers have shed light on the function of the enzyme SLK for the development of nerve cells in the brain. If it is missing, the neurons' branches are less abundant. In addition, it is then more difficult to inhibit the activity of the cells. This is consistent with the fact that there is less SLK in diseased brain tissue from epilepsy patients. Epileptic seizures are characterized by overexci
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Using dunes to interpret wind on Mars
Dunes develop when wind-blown sand organizes into patterns, most often in deserts and arid or semi-arid parts of the world. Every continent on Earth has dune fields, but dunes and dune-like sand patterns are also found across the solar system: on Mars, Venus, Titan, Comet 67P, and Pluto. On Earth, weather stations measure the wind speed and direction, allowing us to predict and understand airflow
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Fans Get Naked in the Arizona Wilderness | Naked and Afraid
Stream Naked and Afraid on discovery+ ► https://www.discoveryplus.com/show/naked-and-afraid About Naked and Afraid: What happens when you put two complete strangers – sans clothes – in some of the most extreme environments on Earth? Each male-female duo is left with no food, no water, no clothes, and only one survival item. #NakedAndAfraid #Discovery #NakedAndAfraidFanEdition Subscribe to Discove
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Sandeep Jauhar: How do emotions affect the heart?
Cardiologist Sandeep Jauhar explains a case where deep grief caused takotsubo cardiomyopathy—also called "broken heart syndrome." He examines the connection emotions have with our most vital organ. (Image credit: Bret Hartman/Courtesy of TED)
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Scientists Created Holograms You Can Touch—You Could Soon Shake a Virtual Colleague's Hand
The TV show Star Trek: The Next Generation introduced millions of people to the idea of a holodeck: an immersive, realistic 3D holographic projection of a complete environment that you could interact with and even touch. In the 21st century, holograms are already being used in a variety of ways, such as medical systems, education, art, security and defense. Scientists are still developing ways to
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Speak more Spanish in public, urge scholars, to combat stigma in US
In 2018, a Montana border patrol agent asked two U.S. citizens in a grocery store parking lot for their government IDs. "I saw that you guys were speaking Spanish, which is very unheard of up here," he reportedly told them. A week later in New York, a white lawyer threatened to call U.S. Immigration and Customs Enforcement agents on restaurant staff who were speaking Spanish with one another.
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Thermal storage for energy transition
In Germany, 55 percent of final energy consumption goes towards heating and cooling. However, a lot of heat dissipates unused because it is not generated as and when required. Thermal storage using zeolite material allows heat to be stored for long periods of time without losing any. Fraunhofer researchers are now working on significantly improving the thermal conductivity of zeolites.
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Making companies crisis-proof
Companies today face a variety of increasingly complex risks. Not least the pandemic has shown how crises can pose an existential threat to companies. The FReE tool of the Fraunhofer Institute for High-Speed Dynamics, Ernst-Mach-Institut, EMI, allows companies to measure their resilience and subsequently be prepared for upcoming crisis scenarios.
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Decadal climate variability in the tropical Pacific
From devastating floods to raging wildfires, climate variability on a global scale is apparent. These extreme weather events, and the world's climate system as a whole, are heavily influenced by the Tropical Pacific, an expanse that stretches from Australia to the Americas.
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The Atlantic Daily: Start Planning Your Holidays Now
In 2020, the fall and winter holidays fell amid a prolonged and terrifying surge in coronavirus cases. Americans were instructed to stay home and hope for a better outlook next year. This year could indeed be brighter, at least for those who got inoculated. Vaccines offer Americans more options for celebrating, two public-health experts told me. But both cautioned that the picture will somewhat d
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Method by which cells exchange vesicles to synchronize their activities.
Much like an ant colony or even people in an office, cells in the body must work together to accomplish their tasks. In all cases, this cooperation depends on communication. Ants do it by smell, people by sound, and, as shown in a new study by CiRA researchers, cells do it by passing vesicles through a system called phenotypic synchrony of cells, or PSyC.
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Early accumulation of tau in the brain predicts memory decline in Alzheimer's disease
Researchers have compared how well different Alzheimer's biomarkers predict the progression of the disease and its effect on the memory. They found that early accumulation of tau proteins in the brain as measured by PET scanner was more effective at predicting memory impairment than biomarkers in the cerebrospinal fluid or amyloid plaque in the brain.
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Virtual care with remote monitoring catches drug errors and reduces patient pain
The study looked at patient outcomes from virtual care and remote automated monitoring (RAM) — video calls with nurses and doctors, and self-monitoring of vital signs using wearable devices. Half of 905 post-surgery patients at nine sites in Hamilton, Kingston, London, Ottawa and Edmonton in Canada were randomized to use technology at home — a cellular tablet and RAM equipment to measure their h
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Without a password
Nature, Published online: 01 October 2021; doi:10.1038/d41586-021-02687-0 Making connections.
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App to link trans patients with safe healthcare providers
A new app called TranZap aims to connect trans people with gender-affirming healthcare providers. The TranZap, the first of its kind in the area of healthcare technology, will collate shared experiences, either good or bad, of healthcare providers that trans people have visited. Other trans patients will rate and review these experiences, building a platform to provide the necessary information t
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On birds—feathered messengers from deep time
When I experienced a great loss in in my early forties—almost a year to the day after another—I went to see my mother in the family home. She wasn't a hugger or giver of advice, so instead we fed the birds. As she had when I was a child, she stood behind me in the kitchen with her shoulder propped against the back door, passing slices of apple and small balls of minced meat into my hand.
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Floating sensors predict plastic on Galapagos beaches
As part of their Galapagos Plastic Free project, physicists Stefanie Ypma and Erik van Sebille are developing an app that tells park rangers on the Galapagos Islands where they can clean up plastic every day. The researchers use drifters, or "floating sensors," to create a model of the complicated ocean currents in and around the archipelago. The first batch of drifters was put to sea from a boat
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Responsible investment is not enough to combat climate change
In their new book on responsible investment, Professor Vesa Puttonen and Bachelor of Science Tatu Puttonen state that politicians cannot outsource their responsibility for combating climate change to asset managers and investors. The book has been published as part of the Aalto University publication series.
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The principle of aquaponics clearly defined
It is one of the big topics in sustainable food production: aquaponics—the combination of fish farming in aquaculture and plant cultivation in hydroponics. That is the short definition. What convinces consumers is the resource-saving approach that saves water, energy and artificial fertilizer. That is the theory. Missing or vague definitions and standards make it difficult to plan and evaluate pla
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Indigenous knowledge and the persistence of the 'wilderness' myth
Aboriginal people in Australia view wilderness, or what is called "wild country," as sick land that's been neglected and not cared for. This is the opposite of the romantic understanding of wilderness as pristine and healthy—a view which underpins much non-Indigenous conservation effort.
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Finerenone imponerer ved EASD
Finerenone kan være på vej til at blive godkendt i blandt andet Danmark inden for kort tid. Nye resultater fra forsøg med lægemidlet indikerer, at det er både hjerte- og nyrebeskyttende.
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Debat: Skal vi have atomkraft i Danmark?
PLUS. Er atomkraft bedre til at afværge klimakrisen end vind, sol, biomasse og andre VE-teknologier? En ny forening anbefaler, at vi dropper alle planer og i stedet bygger 12 atomkraftværker – IDA mener i sit Klimasvar 2045, at en udbygning med VE kan nå klimaneutralitet i 2045. Vi bedt parterne om e…
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T-cellstest osäkra indikatorer på tidigare covid-19
Det finns risk för falskt positivt svar vid T-cellstester som ska visa tidigare infektion i covid-19. T-cellerna kan i vissa fall ha aktiverats av vanligt förkylningsvirus. Det är svårt att få testerna tillräcklig specifika och känsliga. – Även om ett T-cellsvar normalt utvecklas även vid en mild infektion så kunde vi se att de med mild initial sjukdom inte alltid hade ett mätbart SARS-CoV-2-spec
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Long-term sea-level rise requires a worldwide commitment to adaptation
Without adaptation, sea-level rise will put millions more people at risk of flooding, scientists have warned. This requires a timely and adequate commitment to adaptation. Using a novel "scenario-neutral" approach researchers from Deltares, together with Utrecht University, IVM, Newcastle University, Tyndall Centre and Bournemouth University, assess when, where, and how fast coastal areas need to
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Unforced Variations: Oct 2021
Fall is here (in the northern hemisphere at least), along with articles about the impact of climate change on autumnal colors. LandSat9 successfully launched to continue an almost 50 year long series of remote sensing (since 1972!), and the World Economic Forum has proposed and Earth Operations Center to monitor greenhouse gases and climate change. Please stick to climate science topics, and reme
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How to power electronics using mechanical motion
The push toward low powered, energy-saving devices has been a direction the electronics industry has always pursued. The switch to low powered LED lighting is a good example of this trend. Another avenue is the development of energy harvesting, self-sufficient devices. The idea here is to use materials that display piezoelectric and triboelectric effects to convert mechanical energy into electrica
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Active Learning Is Best
There is pretty broad agreement that the pandemic was a net negative for learning among children. Schools are an obvious breeding ground for viruses, with hundreds or thousands of students crammed into the same building, moving to different groups in different classes, and with teachers being systematically exposed to many different students while they spray them with their possibly virus-laden d
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Daily briefing: Jupiter's Great Red Spot is swirling faster
Nature, Published online: 30 September 2021; doi:10.1038/d41586-021-02683-4 The Great Red Spot storm on Jupiter is mysteriously rotating faster and shrinking. Plus, see the first images of a solid made of electrons and learn how Microsoft plans to offset all the carbon it ever emitted.
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A primer for academic entrepreneurs on academic-industrial partnerships
Nature Communications, Published online: 01 October 2021; doi:10.1038/s41467-021-26103-3 Partnerships between academic investigators and industry can accelerate the translation of research findings into life-saving products. The healthcare industry has witnessed heightened interest from universities in capitalizing on the discoveries made by faculty to create intellectual property, form new compa
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In-situ anodic precipitation process for highly efficient separation of aluminum alloys
Nature Communications, Published online: 01 October 2021; doi:10.1038/s41467-021-26119-9 Traditional electrorefining process is limited by deposition potential of the metal itself. Here, the authors explore an in-situ anodic precipitation process based on different solubility of target metal chlorides that can efficiently separate components of aluminum alloys.
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The growing need for controlled data access models in clinical proteomics and metabolomics
Nature Communications, Published online: 01 October 2021; doi:10.1038/s41467-021-26110-4 More and more clinical studies include potentially sensitive human proteomics or metabolomics datasets, but bioinformatics resources for managing the access to these data are not yet available. This commentary discusses current best practices and future perspectives for the responsible handling of clinical pr
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Efficient propyne/propadiene separation by microporous crystalline physiadsorbents
Nature Communications, Published online: 01 October 2021; doi:10.1038/s41467-021-25980-y The separation of propadiene from propyne/propadiene mixtures remains challenging. Here, the authors report a sorbent screening protocol and show that metal-organic frameworks (MOFs) with open metal sites and cage-based molecule traps exhibit high performance for propyne/propadiene separation.
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Boson-peak-like anomaly caused by transverse phonon softening in strain glass
Nature Communications, Published online: 01 October 2021; doi:10.1038/s41467-021-26029-w Strain glass is a new glassy state characterized by frozen ferroelastic nanodomains. Here, the authors discover a low-temperature feature in the specific heat of a strain glass, which is similar to the well-known boson peak anomaly of structural glasses, but cannot be explained by existing mechanisms.
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Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP–PKA signaling
Nature Communications, Published online: 01 October 2021; doi:10.1038/s41467-021-26031-2 The molecular mechanism by which clock neurons transmit timing information to non-clock neurons is poorly understood. Here, the authors show that circadian clocks drive rhythmic expression of hundreds of genes in mushroom body neurons and drive calcium rhythms via NF1-cAMP/PKAC1 signalling in Drosophila.
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Complex small-world regulatory networks emerge from the 3D organisation of the human genome
Nature Communications, Published online: 01 October 2021; doi:10.1038/s41467-021-25875-y Gene-regulatory networks are thought to be complex, and yet perturbation of just a few transcription factors (TFs) can have major consequences. Here the authors apply DNA polymer modelling and simulations to predict how 3D genome structure and TF-DNA interactions can give rise to transcriptional regulation op
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PODCAST: Vi kigger hackerne over skulderen på det mørke internet
Dark web – eller det mørke internet – er en afkrog, hvor de færreste brugere bevæger sig rundt med reelle hensigter. Her handles våben, narko og børneporno, og i ugens Transformator fortæller Version2's journalist Mads Lorenzen om, hvad han fandt, da han fik mulighed for at se sig om i denne sump…
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Simulationstræning klæder psykiatrien bedre på
Ansatte i Psykiatrien i Region Hovedstaden er de første i Danmark, der har mulighed for at øve sig på selvmordsforebyggelse i et sikkert simulationsmiljø. Træning på det nyåbnede Campus for Psykiatrisk Simulation kan hæve det faglige niveau til gavn for patienterne. En god mulighed for at afprøve nye strategier, siger en kursist.
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Hawaii's Kilauea volcano erupts
Hawaii's Kilauea volcano, one of the world's most active, has erupted but its lava so far is limited to its central crater and not threatening inhabited areas, authorities said Thursday.
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A Curious Case of Auditory-Gustatory Synesthesia… in someone who can't smell
A fascinating case study from 1907 describes the self-reported sensory "taste" experiences evoked by hearing specific words, names, or sounds ( Pierce, 1907 ). The subject was a young woman about to graduate from college. As far as she could tell, she's always had these experiences, and for most of her life she didn't know they were unusual. This surprise upon discovering the uniqueness of one's
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Black Americans are most likely to experience fatal police violence
More than 55% of deaths from police violence in the USA from 1980-2018 were misclassified or unreported in official vital statistics reports according to a new study in The Lancet. The highest rate of deaths from police violence occurred for Black Americans, who were estimated to be 3.5 times more likely to experience fatal police violence than white Americans.
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Mange patienter med mistænkt prostatakræft har ikke adgang til den bedste diagnostik
Regionerne kæmper med at få MR-skannere på plads, og få uddannet radiologer og urologer, der kan sikre, at patienter med mistænkt prostatacancer kan få en mere præcis diagnostik. Det betyder, at mens nogle patienter får den bedst mulige behandling, så må andre lade sig nøjes med den markant mindre præcise ultralydsskanning. Formanden for patientforeningen for prostatakræftramte fortæller om et st
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Lang vej endnu til en national MR-diagnostik af prostatacancer
De fem regioner befinder sig vidt forskellige steder i forhold til, hvor langt de er nået med implementering af nye kliniske retningslinjer for prostatacancerdiagnostik. Mens man i hovedstaden i flere år har tilbudt MR-skanning til alle relevante patienter, har man i Region Midtjylland indført en øvre aldersgrænse på 65 år.
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Få styr på influenzavaccinerne
Gennem de seneste år er der dog kommet så mange administrative forhindringer, at mange praktiserende læger overvejer helt at droppe den service, det er, at vaccinere egne patienter.
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Hvis det var brystkræft, var der rullet hoveder
Selvom ulighed i sundhed er blevet det prisme, som sundhedsvæsenet ofte bedømmes gennem, så handler det her ikke kun om ulighed. Det handler om, at alle – også prostatakræftpatienter – skal have lige adgang til den bedste diagnostik og behandling.
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Falling Water, Rising Rocks, 1834
Intrigued by an optical illusion he experienced while traveling in Scotland, Robert Addams wrote what is now considered one of the definitive observational accounts of so-called motion aftereffects.
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Ulighed i børnesundhed i Danmark
Alle børn i Danmark har lige ret til sundhed, men for en udsat gruppe børn og unge med anden etnisk baggrund holder det ikke i praksis. Vi har ikke tilbud til dem. Kun til deres forældre.
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Husk at spørge os unge, inden I laver regler for vores forbrug af alkohol
Det er naivt at tro, at man f.eks. på ungdomsuddannelserne kan forbyde sig til en bedre alkoholkultur blandt unge. Hvis festerne omdannes til rene sodavandsdiskoteker, risikerer man i stedet, at de rykker væk fra det trygge rum på ungdomsuddannelserne, hvilket både vil skabe større utryghed og ødelægge en central del af det at være ung på et gymnasium eller en erhvervsskole.
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Looking beyond DNA to see cancer with new clarity
Researchers have mapped out how hundreds of mutations involved in two types of cancer affect the activity of proteins that are the ultimate actors behind the disease. The work points the way to identifying new precision treatments that may avoid the side effects common with much current chemotherapy.
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More effective treatment of Alzheimer's
Researchers have designed new antibodies that might provide more effective treatment methods for Alzheimer's disease. By designing antibodies that bind even to the smaller aggregates, or clumps, of the amyloid-beta protein, it may be possible to check the progress of the disease.
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AMD: Reading ability crucial indicator of functional loss
In geographic atrophy, a late form of age-related macular degeneration (AMD), reading ability is closely related to the altered retinal structure. Reading speed makes everyday functional impairment measurable, which the most common functional test in ophthalmology — the best-corrected visual acuity assessment – cannot reflect. Retinal imaging can be used to assess loss of reading ability even whe
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Bioengineers develop new class of human-powered bioelectronics
A team of bioengineers has invented a novel soft and flexible self-powered bioelectronic device. The technology converts human body motions — from bending an elbow to subtle movements such as a pulse on one's wrist — into electricity that could be used to power wearable and implantable diagnostic sensors.
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China's clampdown on fake-paper factories picks up speed
Nature, Published online: 01 October 2021; doi:10.1038/d41586-021-02587-3 As part of a misconduct crackdown, Chinese funders are penalizing researchers who commission sham journal articles from 'paper mills', but some say the measures still don't go far enough.
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Coral microbiome is key to surviving climate change
The microbiomes of corals — which comprise bacteria, fungi and viruses — play an important role in the ability of corals to tolerate rising ocean temperatures, according to new research. The team also identified several genes within certain corals and the symbiotic photosynthetic algae that live inside their tissues that may play a role in their response to heat stress. The findings could inform
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Most cases of never-smokers' lung cancer treatable with mutation-targeting drugs
Despite smoking's well-known role in causing lung cancer, a significant number of patients who develop lung tumors have never smoked. While scientists are still working to understand what spurs cancer in so-called 'never-smokers,' a study suggests that 78% to 92% of lung cancers in patients who have never smoked can be treated with precision drugs already approved by the Food and Drug Administrati
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New treatment for inflammatory bowel disease: Opioids may cure that 'bad gut feeling'
Opioid receptors play key roles in regulating our senses and emotions. Recently, their discovery outside the nervous system raised several questions about the effects of opioids on the immune system. Now, researchers have shown that KNT-127 — a drug that targets delta opioid receptors — can reduce pro-inflammatory signals in the colon. Their research highlights the immunomodulatory properties of
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Salt stress alters legume responses to symbiotic rhizobacteria by modulating gene expression
Crop legumes are an integral part of sustainable agriculture, as several of these species represent an important protein source for both human and animal populations. Legumes engage in a unique and beneficial interaction with a group of soil bacteria, collectively called rhizobia. Rhizobium-legume symbioses lead to the development of new plant organs on the roots called nodules, which host rhizobi
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Study: Just 1 of 5 people with disabilities works from home; millions still do not have the option
Working from home could revolutionize job opportunities for people with mobility impairments, chronic medical conditions, and other disabilities, but a towering obstacle still stands in the way more than 18 months into the pandemic. A report by the Rutgers Program for Disability Research finds a disproportionate number of people with disabilities work in places like factories, restaurants, and ret
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Grimes Says She's Being Harassed After Elon Musk Breakup
Hate and Harassment Claire "Grimes" Boucher has had a rough time after breaking up with Elon Musk last week. "I wrote and produced this song this week in response to all the privacy invasion, bad press, online hate and harassment by paparazzis I've experienced this week," Grimes wrote in the caption of a new song she posted to Instagram today . View this post on Instagram A post shared by ︎𝔊𝔯𝔦
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Dynamic pregnancy intentions
A study found that pregnancy intentions often change over as short as a 12-month time period, and that they specifically vary with partner status, household income, and employment status.
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Xbox Head Phil Spencer Claims Supply Issues Will Continue Deep Into 2022
The word from an increasing number of voices in the semiconductor industry is that shortages and production problems are here to stay for the foreseeable future. Xbox head Phil Hughes is the latest executive to sound off on the problem, and he agrees with assessments from Lisa Su and Jensen Huang: "I think it's probably too isolated to talk about it as just a chip problem," Hughes told TheWrap .
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Florida Man Returns Missing NASA Moon Rock he Bought at Garage Sale
Finders Keepers A missing Moon rock originally gifted to the state of Louisiana by then-President Richard Nixon has been returned after a man in Florida found it sitting in an old box in his home. The man told CollectSPACE that he must have bought the rock, which vanished without a trace years ago, at some garage sale within the last 15 or so years — and that he never realized that he had bought
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Signaling from neighboring cells provides power boost within axons
Nerve cells (neurons) send signals throughout the brain and the body along long processes called axons; these communication and information processes consume high levels of energy. A recent study shows that the support cells around axons provide a way to boost local energy production. The new findings help explain how long axons maintain sufficient energy levels and could have implications for the
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Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs [Cell Biology]
Approximately 40% of human messenger RNAs (mRNAs) contain upstream open reading frames (uORFs) in their 5′ untranslated regions. Some of these uORF sequences, thought to attenuate scanning ribosomes or lead to mRNA degradation, were recently shown to be translated, although the function of the encoded peptides remains unknown. Here, we…
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Automated design of pulse sequences for magnetic resonance fingerprinting using physics-inspired optimization [Engineering]
Magnetic resonance fingerprinting (MRF) is a method to extract quantitative tissue properties such as T1 and T2 relaxation rates from arbitrary pulse sequences using conventional MRI hardware. MRF pulse sequences have thousands of tunable parameters, which can be chosen to maximize precision and minimize scan time. Here, we perform de…
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Topological spin/structure couplings in layered chiral magnet Cr1/3TaS2: The discovery of spiral magnetic superstructure [Physics]
Chiral magnets have recently emerged as hosts for topological spin textures and related transport phenomena, which can find use in next-generation spintronic devices. The coupling between structural chirality and noncollinear magnetism is crucial for the stabilization of complex spin structures such as magnetic skyrmions. Most studies have been focused on…
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Circuit-specific enteric glia regulate intestinal motor neurocircuits [Neuroscience]
Glia in the central nervous system exert precise spatial and temporal regulation over neural circuitry on a synapse-specific basis, but it is unclear if peripheral glia share this exquisite capacity to sense and modulate circuit activity. In the enteric nervous system (ENS), glia control gastrointestinal motility through bidirectional communication with…
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Fe-catalyzed sulfide oxidation in hydrothermal plumes is a source of reactive oxygen species to the ocean [Earth, Atmospheric, and Planetary Sciences]
Historically, the production of reactive oxygen species (ROS) in the ocean has been attributed to photochemical and biochemical reactions. However, hydrothermal vents emit globally significant inventories of reduced Fe and S species that should react rapidly with oxygen in bottom water and serve as a heretofore unmeasured source of ROS….
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Ecological diversification reveals routes of pathogen emergence in endemic Vibrio vulnificus populations [Microbiology]
Pathogen emergence is a complex phenomenon that, despite its public health relevance, remains poorly understood. Vibrio vulnificus, an emergent human pathogen, can cause a deadly septicaemia with over 50% mortality rate. To date, the ecological drivers that lead to the emergence of clinical strains and the unique genetic traits that…
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Intermolecular latency regulates the essential C-terminal signal peptidase and sortase of the Porphyromonas gingivalis type-IX secretion system [Biochemistry]
Porphyromonas gingivalis is a keystone pathogen of the human dysbiotic oral microbiome that causes severe periodontitis. It employs a type-IX secretion system (T9SS) to shuttle proteins across the outer membrane (OM) for virulence. Uniquely, T9SS cargoes carry a C-terminal domain (CTD) as a secretion signal, which is cleaved and replaced…
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Computational modeling identifies multitargeted kinase inhibitors as effective therapies for metastatic, castration-resistant prostate cancer [Applied Biological Sciences]
Castration-resistant prostate cancer (CRPC) is an advanced subtype of prostate cancer with limited therapeutic options. Here, we applied a systems-based modeling approach called kinome regularization (KiR) to identify multitargeted kinase inhibitors (KIs) that abrogate CRPC growth. Two predicted KIs, PP121 and SC-1, suppressed CRPC growth in two-dimensional in vitro experiments…
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The nuclear ubiquitin ligase adaptor SPOP is a conserved regulator of C9orf72 dipeptide toxicity [Neuroscience]
A hexanucleotide repeat expansion in the C9orf72 gene is the most common cause of inherited amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Unconventional translation of the C9orf72 repeat produces dipeptide repeat proteins (DPRs). Previously, we showed that the DPRs PR50 and GR50 are highly toxic when expressed in Caenorhabditis…
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Structural and energetic analysis of metastable intermediate states in the E1P-E2P transition of Ca2+-ATPase [Biophysics and Computational Biology]
Sarcoplasmic reticulum (SR) Ca2+-ATPase transports two Ca2+ ions from the cytoplasm to the SR lumen against a large concentration gradient. X-ray crystallography has revealed the atomic structures of the protein before and after the dissociation of Ca2+, while biochemical studies have suggested the existence of intermediate states in the transition…
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PRAMEF2-mediated dynamic regulation of YAP signaling promotes tumorigenesis [Medical Sciences]
PRAMEF2 is a member of the PRAME multigene family of cancer testis antigens, which serve as prognostic markers for several cancers. However, molecular mechanisms underlying its role in tumorigenesis remain poorly understood. Here, we report that PRAMEF2 is repressed under conditions of altered metabolic homeostasis in a FOXP3-dependent manner. We…
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Altered effective connectivity in sensorimotor cortices is a signature of severity and clinical course in depression [Psychological and Cognitive Sciences]
Functional neuroimaging research on depression has traditionally targeted neural networks associated with the psychological aspects of depression. In this study, instead, we focus on alterations of sensorimotor function in depression. We used resting-state functional MRI data and dynamic causal modeling (DCM) to assess the hypothesis that depression is associated with…
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Encoding hierarchical assembly pathways of proteins with DNA [Chemistry]
The structural and functional diversity of materials in nature depends on the controlled assembly of discrete building blocks into complex architectures via specific, multistep, hierarchical assembly pathways. Achieving similar complexity in synthetic materials through hierarchical assembly is challenging due to difficulties with defining multiple recognition areas on synthetic building blocks…
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High-performance AEM unitized regenerative fuel cell using Pt-pyrochlore as bifunctional oxygen electrocatalyst [Engineering]
The performance of fixed-gas unitized regenerative fuel cells (FG-URFCs) are limited by the bifunctional activity of the oxygen electrocatalyst. It is essential to have a good bifunctional oxygen electrocatalyst which can exhibit high activity for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). In this regard, Pt-Pb2Ru2O7-x is synthesized…
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Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-{alpha}/hepcidin axis [Physiology]
Iron is an essential biometal, but is toxic if it exists in excess. Therefore, iron content is tightly regulated at cellular and systemic levels to meet metabolic demands but to avoid toxicity. We have recently reported that adaptive thermogenesis, a critical metabolic pathway to maintain whole-body energy homeostasis, is an…
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Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition [Microbiology]
The coronaviruses responsible for severe acute respiratory syndrome (SARS-CoV), COVID-19 (SARS-CoV-2), Middle East respiratory syndrome-CoV, and other coronavirus infections express a nucleocapsid protein (N) that is essential for viral replication, transcription, and virion assembly. Phosphorylation of N from SARS-CoV by glycogen synthase kinase 3 (GSK-3) is required for its function…
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Can math make redistricting more fair?
Just before midnight on Tuesday, Sept. 28, an independent, bipartisan commission voted to approve a new map for Colorado's congressional districts––dividing the state into eight territories with roughly equal populations.
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Fungal transplants from close relatives help endangered plants fight off disease
For the endangered Hawaiian plant Eugenia koolauensis, fungi could be both its demise and its savior. The fungal pathogen myrtle rust (Austropuccinia psidii) has been devastating populations of the endemic tree, along with many other native and cultivated plants. However, researcher Mason Kamalani Chock thinks part of the solution might be more fungi.
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Radiation makes heart cells young again to treat arrhythmia
Radiation therapy can reprogram heart muscle cells to what appears to be a younger state, fixing electrical problems that cause a life-threatening arrhythmia without the need for a long-used, invasive procedure, new research suggests. In that invasive procedure—catheter ablation—a catheter is threaded into the heart, and the tissue that triggers the life-threatening irregular heart rhythm—called
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When will the COVID pandemic end?
The worst of the pandemic may finally be over, according to new modeling results from a consortium of researchers advising the US Centers for Disease Control and Prevention. The team's COVID-19 Scenario Modeling Hub , which is co-coordinated by researchers at Penn State, projects that COVID-19 cases will decrease across the United States, barring the emergence of any new variants or major changes
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Fewer people used city parks during first COVID-19 summer
Contrary to anecdotal reports of a spike in new users during the COVID-19 pandemic, fewer people used outdoor parks and trails in urban areas of North Carolina during two summer months of 2020, according to a new study. The study also found that that the drop-off in urban park access was more likely to affect minorities and people from lower-income backgrounds. "Visitation declined in urban and c
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This Noise Cancelling App Uses AI To Eliminate Unwanted Sounds From Calls and Meetings
More people are working from home now than ever, which means that more of us have become painfully aware just how noisy everybody's homes can be. Online work meetings can be convenient and safer than meeting in an office conference room but not anywhere near as quiet, unless of course the participants in that meeting are using Krisp , an incredible (and free to use) noise cancelling app that uses
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Scientists create material that can both move and block heat
Scientists have invented a new way to funnel heat around at the microscopic level: a thermal insulator made using an innovative technique. They stack ultra-thin layers of crystalline sheets on top of each other, but rotate each layer slightly, creating a material with atoms that are aligned in one direction but not in the other. The result is a material that is extremely good at both containing he
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