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The New Anti-comedy of Jon Stewart
It seems obvious now, in hindsight, that people expected too much from comedy in the first two decades of the new millennium—that it could make us better , make us healthier , undermine despots , change minds , enable progress , even save the republic . Those were enticing ideas, but Jon Stewart never seemed to fall for them. His job was making a comedy show, as he essentially told Tucker Carlson
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El Salvador Officially Starts Mining Bitcoin Using Power From an Actual Volcano
Volcano Mining El Salvador has officially begun to mine Bitcoin using the power harnessed from an honest-to-god volcano — and the so-called "volcanode" has already made 0.00599179 bitcoin, or about $269, according to a tweet by president Nayib Bukele . "We're still testing and installing, but this is officially the first Bitcoin mining from the volcanode," Bukele wrote. Relying on green geotherma
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BepiColombo spacecraft sends its first images of Mercury during flyby
European-Japanese probe swoops in to almost 200km above Sun's nearest planet, photographing its pock-marked features The European-Japanese BepiColombo spacecraft has sent back its first images of Mercury, as it swung by the solar system's innermost planet while on a mission to deliver two probes into orbit in 2025. The mission made the first of six flybys of Mercury at 11.34pm GMT on Friday, usin
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Neuralink Co-Founder Predicts That Humanity Will Get "Wrecked"
Departed Neuralink co-founder Max Hodak has a grim take on the fate of humanity: the robot uprising is inevitable, and they will leave humans in the dust. Key to his argument, which is admittedly a little hard to follow, is that AI will likely not adhere to humanity's preconceptions about political and economic models for society. "Humans are objectively bad with socialism (and on the contrary, c
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Doctors, receptionists and practice teams quit after wave of hostility over GP appointments
Fears of mass exodus as abuse by patients skyrockets over blood tests, jabs and face-to-face consultations Coronavirus – latest updates See all our coronavirus coverage Senior doctors have warned that practice staff and GPs are quitting after an unprecedented and escalating wave of abuse from patients that has followed weeks of public pressure over face-to-face appointments. Practice managers, re
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UK might not be over the worst, scientists warn, as Covid case numbers stay high
Inoculation programme must be stepped up before the onset of winter Coronavirus – latest updates See all our coronavirus coverage Britain is heading into winter with the number of Covid cases remaining at a worryingly high level. At the same time, the nation's vaccination programme appears to have stalled. That is the bleak view of leading epidemiologists who have warned that the worst effects of
10h
In Netflix's Squid Game, Debt Is a Double-Edged Sword
For the chance to escape severe debt, the characters in Netflix's hugely popular survival drama Squid Game would risk anything, even death. Take the protagonist Seong Gi-hun. Unemployed, he spends his days in Seoul gambling on horse races and has signed away his organs as collateral to his creditors. His deficits, both financial and personal, hurt the people closest to him: He hasn't paid child s
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Former Jeff Bezos Space Employee: "I Really Wished He Was the Person We All Thought He Was"
Just Disappointed Alexandra Abrams, the former Head of Employee Communications at Jeff Bezos' spaceflight company, Blue Origin, says she's disappointed in Bezos for allowing a toxic culture to take hold at the company. We previously covered a Lioness open letter written by Abrams and a cohort of other current and former Blue Origin employees in which they say the company's senior leadership foste
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Blockchain Company Accidentally Gives Out $90 Million, Begs People to Give It Back
It's just another day in the Wild West of cryptocurrency markets. Users of the blockchain startup Compound got an unusual surprise. Millions of dollars worth of COMP tokens, rewards for crypto mining, were mistakenly given out Wednesday night — and the exchange is now groveling and threatening for its money back. A decentralized finance or "DeFi" protocol like Compound allows investors to trade d
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Hackers Attacked a Hospital and Allegedly Killed a Newborn Baby
A woman who gave birth at a hospital that had been brought to its knees by a ransomware hack is now suing over the death of her newborn daughter. The death appears to mark the first official casualty of a ransomware hack, in which hackers seize control of a computer network and demand payment , usually in cryptocurrency, to restore it — a crime that, clearly, can be lifethreatening when directed
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Hyggesfritt skogsbruk vinner mark
Hyggesfritt skogsbruk är en av megatrenderna inom det globala skogsbruket. Det är hållbart, ekonomiskt fördelaktigt och ger rikare biodiversitet enligt förespråkare. Men forskare vid det svenska skogsbrukets forskningsinstitut är tveksamma till metoden. De vill inte överge kalhyggesbruket. – Svenskt skogsbruk är fantastiskt, och kalhyggen det bästa sättet att få fram virke till industrin, säger Ro
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Did Pfizer Peak Too Soon?
The Delta variant's arrival this summer delivered a blow to the nation's entire coronavirus arsenal, but its impact on the champion of last year's vaccine race—Pfizer—has been particularly humbling. Compared with Moderna's competing shot, Pfizer's vaccine seems to induce half the amount of virus-fighting antibodies , and is associated with nearly twice as many breakthrough infections , according
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Where Is My Mother's Safety Net?
M y dad didn't believe my mom when she announced that she was leaving him. Desperate, after years spent begging him to accept treatment for a worsening mental illness, she threatened to move out if he didn't comply with his doctor's recommendations. "Where will you go?" he asked. A former stay-at-home parent of five grown children, all just beginning their careers around the country, my mom had n
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Blue Origin Employees Say They Don't Think Its Rocket Is Safe, Wouldn't Ride In It
Hard Pass A small cohort of current and former employees of Blue Origin, Jeff Bezos's spaceflight company, recently penned an article questioning the company's commitment to safety. We wrote yesterday about the employees' claims that Blue Origin harbors a shockingly sexist work culture. Another alarming takeaway from the letter , though, comes from a completely different direction, claiming that
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Big Business Is Bankrolling an Effort to Kill the Democratic Climate Bill
Four years ago, when President Donald Trump announced that he would take the United States out of the Paris Agreement , the world's largest companies leapt into action. Tim Cook, Apple's CEO, personally beseeched Trump to remain in the pact. Bob Iger, Disney's chief executive, resigned from a White House advisory council in protest. Goldman Sachs's CEO, Lloyd Blankfein, sent his first-ever tweet
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A novel method for installing sulfur into complex molecules
A group of highly reactive compounds called persulfides have provoked great curiosity among biochemists, because of their role in nature, and how they interact with proteins to change their structure and function, affecting health, aging and disease processes.
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Check Out This Awesome Drone Footage From Inside a Hurricane
Eye of the Hurricane The National Oceanic and Atmospheric Administration (NOAA) has released dramatic footage from inside a hurricane recorded by a "Saildrone," a wind-powered and uncrewed boat developed by a company of the same name. The daredevil watercraft is equipped with a "hurricane wing," allowing it to take a huge battering and survive Hurricane Sam's 50-foot waves and winds of over 120 m
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Inspired by photosynthesis, scientists double reaction quantum efficiency
Drawing on inspiration from photosynthesis and the way it can achieve high efficiency in plants, Regents Professors Tom Moore and Ana Moore in Arizona State University's School of Molecular Sciences and their groups, together with colleagues from the Department of Chemistry at Princeton University (including Professors Gregory Scholes and Robert Knowles), have introduced a bioinspired catalyst tha
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How flawed diamonds 'lead' to flawless quantum networks
The color in a diamond comes from a defect, or "vacancy," where there is a missing carbon atom in the crystal lattice. Vacancies have long been of interest to electronics researchers because they can be used as 'quantum nodes' or points that make up a quantum network for the transfer of data. One of the ways of introducing a defect into a diamond is by implanting it with other elements, like nitro
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Grimes Spotted Reading Karl Marx After Breaking Up With Elon Musk
Rebound Guy Just a week after breaking up with SpaceX and Tesla CEO Elon Musk, acclaimed musician Claire "Grimes" Boucher has been spotted with a new guy. The lucky fellow? German economist Karl Marx, best known as one of the key thinkers behind communism during the mid-1800s. In shots published by Page Six , in fact, Grimes can be seen leafing through Marx's influential volume " The Communist Ma
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Cake was my first love – it sees me through life's highs and lows
There should be no guilt with cake, only romance – in the making, the display, the history… and, of course, the eating The Great British Bake Off is back! Sales of baking utensils skyrocket when the amateur baking show is on. It appears we're all cake mad. But I've always been mad as a box of doughnuts for cake, long before the GBBO started. In fact, it's one of my loves – not one of my vices. Cak
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The truth about artificial intelligence? It isn't that honest | John Naughton
Tests of natural language processing models show that the bigger they are, the bigger liars they are. Should we be worried? We are, as the critic George Steiner observed, "language animals". Perhaps that's why we are fascinated by other creatures that appear to have language – dolphins, whales, apes, birds and so on. In her fascinating book, Atlas of AI , Kate Crawford relates how, at the end of
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Jeff Bezos Is Being Knocked Back Down to Earth
On the night he went to space, Jeff Bezos threw a party for his employees. The hotel restaurant in Van Horn, a town in West Texas not far from the launch site, was thrumming. Inside, someone had cut into the frosted Blue of Blue Origin on a big vanilla sheet cake. Outside, a live band jammed beneath a tent skimmed with café lights. Everyone was a little buzzed and a lot relieved. They had just la
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Company Claims Pill Cuts Risk of Dying of COVID-19 in Half
Pharmaceutical company Merck claims its new COVID-19 pill, called molnupiravir, can reduce the risk of hospitalization and even death from the coronavirus by half, according to newly announced Phase III clinical trial results. The company is now applying for Emergency Use Authorization from the US Food and Drug Administration. It's a promising development for new treatments against severe cases o
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Coronavirus treatments: the potential 'game-changers' in development
After positive clinical trials for antiviral drug Molnupiravir, it joins other medicines that have shown promise Coronavirus – latest updates See all our coronavirus coverage The first clinical trial results showing a positive effect for a pill that can be taken at home has been hailed as a potential gamechanger that could provide a new way to protect the most vulnerable people from the worst eff
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Employers Have Been Offering the Wrong Office Amenities
Before you read any further, take a long, slow, deep breath. Congratulations! If you're sitting in a typical American home, office building, or school, about 3 percent of the air you breathed in recently came out of the lungs of the people in the room with you right now. Breathing in one another's air is kind of nasty when you think about it. We would never drink from the same cup of water that e
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Universities Are Shunning Their Responsibility to Democracy
I was born in Canada , and my sense of national identity, like that of many Canadians, was formed in direct relation—perhaps in opposition—to the great colossus to the south. We were a country that aspired not to the lofty abstractions of "life, liberty, and the pursuit of happiness" but to the more prosaic benefits of "peace, order, and good government." I have always been proud of Canada's basi
7h
Gene editing will just perpetuate disastrous factory farming | Letters
Instead of trying to cosh nature into submission, our farmers should be improving the health of the soil and the diversity of their crops and animals A quotation leapt to mind when reading " Gene editing 'would allow us to create hardier farm breeds ' (News): "For every complex problem there is an answer that is clear, simple, and wrong" (HL Mencken). Application of magic bullet "solutions" has go
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Now Explain What the Problem Is
Academics like me love to describe things as "problematic." But what do we mean? We're not saying that the thing in question is unsolvable or even difficult. We're saying—or implying—that it is objectionable in some way, that it rests uneasily with our prior moral or political commitments. For instance, when I described applying Ancient Greek free-speech ideals to social media as "problematic" in
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The Power of Artistic Exile
The filmmaker and polymath Melvin Van Peebles died last week at the age of 89 at his home in New York. He is best known as the auteur behind the first hit blaxploitation film, Sweet Sweetback's Baadasssss Song (1971), but he was an artist of great breadth and versatility: sculptor; poet; painter; composer and, with Gil Scott-Heron, progenitor of rap and hip-hop; playwright; gifted novelist. I wou
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Spin polarization induced by shear flow
Chinese researchers recently discovered a new effect that can generate spin-polarization in fluid. The new effect, which is called "shear-induced polarization (SIP)," predicts that shear flow can induce polarization in the momentum space.
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The relationship sabotage scale: quantifying why we undermine ourselves in love
Developed over the course of five studies, the relationship sabotage scale is designed to give analytical rigour to a term more common in pop culture Do you feel constantly criticised by your partner? Do you sometimes check their social media profiles? Will you admit to them if you know you're wrong about something? If you strongly agree or disagree with some of these statements, you might find y
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Rules and advice don't slow the spread of the virus – human behaviour does | David Spiegelhalter and Anthony Masters
Surveys can help us understand how the pandemic is influenced by our choices Recent queues for fuel have shown the consequences of abrupt changes in behaviour. Almost as sudden were the changes around the first lockdown in March 2020, when close meetings between people plummeted by about three-quarters. We know this through the CoMix contact survey from the London School of Hygiene & Tropical Medi
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The Atlantic Daily: Five Podcasts for the Weekend
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox. Fall is here, and the air is getting crisp, which means it's the perfect time to snuggle up and press play on a new work of audio storytelling. I asked writers and editors from around our newsroom
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A non-invasive way to image Wigner crystals directly
A team of researchers at the University of California at Berkeley, working with a group at Lawrence Berkeley National Laboratory, has developed a non-invasive way to image Wigner crystals directly. In their paper published in the journal Nature, the group describes their approach and explain how it could be used to advance research regarding Wigner crystal states. Carmen Rubio-Verdú with Columbia
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The 'Magical Episode 4' Theory
What feels like eons ago, a friend asked for my advice on an important subject: He was trying to decide whether to start Friday Night Lights or Breaking Bad , both of which had recently become available on Netflix. Specifically, he wanted to know how many episodes he should watch of each to see which would hook him faster. My mind short-circuited. Although both are modern classics, the two series
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The Books Briefing: The Essential Qualities of a Book
What is a book? Is it simply the text we read, whether on bound pages or on a screen? Or is it a tangible object, something held with human hands and made richer by the way we physically interact with it? These are questions that Atlantic writers have been considering for at least a decade, and they don't have easy, definitive answers. Recently, the Atlantic contributing writer Ian Bogost made th
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Covid: scientists warn UK may have worst to come; Israel tightens vaccine passport rules – as it happened
Fears the indoor socialising will spread virus in UK ; Israel says people only eligible for green pass if they have received a booster jab . This live blog has closed – for the latest on the global Covid situation, please see our dedicated page UK might not be over the worst, scientists warn New Zealand widens Covid lockdown as Delta spreads UK to slash international travel 'red list' to just nin
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Marine heatwaves could wipe out an extra six per cent of a country's fish catches, costing millions their jobs
Extremely hot years will wipe out hundreds of thousands of tons of fish available for catch in a country's waters in this century, on top of projected decreases to fish stocks from long-term climate change, a new study predicts. Modelling a worst-case scenario where no action is taken to mitigate greenhouse gas emissions they projected a six per cent drop in the amount of potential catches per yea
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Directly into the brain: A 3D multifunctional and flexible neural interface
Although measuring the electrical activity of neurons is useful in many disciplines, making durable neural interfacing brain chip implants with negligible adverse effects has proven challenging. Now, scientists have developed a flexible multifunctional neural interface that can not only register local brain activity in real time, but also deliver a steady flow of drugs through innovative microflui
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Gene therapy can restore vision after stroke
Vision loss can be a side effect from stroke. Neurons don't regenerate, and stem cell therapy is costly, difficult, and chancy. Researchers have figured out a way to use gene therapy to recover lost vision after a stroke in a mouse model.
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Is your machine learning training set biased? How to develop new drugs based on merged datasets
Polymorphs are molecules that have different molecular packing arrangements despite identical chemical compositions. In a recent paper, researchers at GlaxoSmithKline (GSK) and the Cambridge Crystallographic Data Centre (CCDC) combined their proprietary (GSK) and published (CCDC) datasets to better train machine learning (ML) models to predict stable polymorphs to use in new drug candidates.
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'Time machine' reverses pancreatic cancer progression
What makes pancreatic cancer so deadly is its covert and quick spread. Now, a "time machine" has shown a way to reverse the course of cancer before it spreads throughout the pancreas. "These findings open up the possibility of designing a new gene therapy or drug because now we can convert cancerous cells back into their normal state," says Bumsoo Han, a professor of mechanical engineering at Pur
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The End of Bias by Jessica Nordell review – how to remove your blinkers
This thoughtful case for mounting a lifelong challenge to our own assumptions focuses on unconscious bias – but leaves overt prejudice largely unexamined We often think of bias as a problem that other people have. It's harder to find someone willing to admit to it in themselves. That was what struck me reading American journalist Jessica Nordell's thoughtful book, The End of Bias, which I picked
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Reading Between the Lines of the New Biden Impression on SNL
Saturday Night Live began its 47th season with a brand-new cast member staring down the camera lens, a pointed announcement that the show is looking to stay ahead of the curve. That actor was James Austin Johnson, a comedian who gained a Twitter following for his short, surreal impressions, most famously of Donald Trump, during which he rambled through the streets while delivering strange soliloq
28min
Sir Antony Hewish obituary
Radio astronomer who won the Nobel prize for physics for his role in the discovery of pulsars In 1967, a team led by the radio astronomer Antony Hewish, who has died aged 97, discovered pulsars, rapidly pulsating radio sources that turned out to be due to rotating, magnetised neutron stars, the ultra-dense collapsed remnants of massive stars. This was one of the most exciting astronomical events o
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With Bitcoin IRA, It's Easy to Use Crypto to Invest for the Future
It's the most basic financial advice there is, but it bears repeating: it's always a good idea to save up for retirement . If you were lucky enough to be an early adopter in Bitcoin, you already know that it presented a great opportunity to build up a decent nest egg. But using bitcoins or other cryptocurrencies to save up for retirement isn't exactly traditional financial planning. Not, that is,
53min
The Music of Proteins Is Made Audible Through a Computer Program That Learns From Chopin
With the right computer program, proteins become pleasant music. There are many surprising analogies between proteins , the basic building blocks of life, and musical notation. These analogies can be used not only to help advance research, but also to make the complexity of proteins accessible to the public. We're computational biologists who believe that hearing the sound of life at the molecula
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This Infrared Sauna Blanket Helps Fight Seasonal Affective Disorder
Thanks to Seasonal Affective Disorder, better known as SAD, winter can be a pretty trying time for most people. Psychology Today reports SAD affects 10-million Americans with another 10-to-20 percent of people suffering from a milder form of the disorder. Compound that with the limitations set by the pandemic, and winter can truly feel like a never-ending hell. However, one of the best ways to co
3h
Jim Townsley obituary
My father, Jim Townsley, who has died aged 85, was a gentle, generous and thoughtful man who spent his working life as an industrial chemist. In retirement, his aptitude for listening, understanding and supporting the emotional needs of others found expression through voluntary work as a trained counsellor. Born in Ilford, east London, to Jim Sr, a post office worker, and Gertrude (nee Knight), a
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Put Microsoft Excel At Your Fingertips With 40% Off These Training Bundles
Data is everywhere , and increasingly central to our lives. You can put it at your fingertips with these courses from our VIP Sale, 40% off with code VIP40 for a limited time. The Premium 2021 Microsoft Excel & Data Certification Bundle Looking to use Excel for more than simple functions? This 24-course bundle touches every possible aspect, from data visualization to day-to-day automation tips to
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The Last Stop
Illustrations by Miki Lowe The poet Adam Zagajewski spent his life trying to make meaning of what he had lived through. When he was a child, his family was relocated within Poland after World War II; as a young man, he was exiled from the country altogether for writing protest poems against the country's authoritarian government. "I lost two homelands," he once said , "but I sought a third: a spa
5h
Master The Blockchain With 40% Off These FinTech Training Classes
Cryptocurrency, blockchain, and fintech have gone from buzzwords to supposedly so effective, a hamster can make a fortune . Whether or not that's true, you'll need to know what you're doing before you invest, and you can save 40% on each of these courses to learn how with the code VIP40. The Complete Cryptocurrency Investment Bundle This 5-course bundle is a perfect starting point for new investo
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Rick Hits 6 Figures in Just 3 Days! | Gold Rush
Stream Gold Rush on discovery+: https://www.discoveryplus.com/show/gold-rush #Discovery #GoldRush #Gold Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitter.com/Discovery From: Discovery
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Tony Beets Wants a $2,500,000 Bulldozer | Gold Rush: Winter's Fortune
Stream Full Episodes of Gold Rush: Winter's Fortune: discovery+ ► https://www.discoveryplus.com/show/gold-rush-winters-fortune-us #Discovery #GoldRush #GoldRushWintersFortune Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Foll
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This Week's Awesome Tech Stories From Around the Web (Through October 2)
ROBOTICS How DeepMind Is Reinventing the Robot Tom Chivers | IEEE Spectrum "Having conquered Go and protein folding, the company turns to a really hard problem. …To get to the next level, researchers are trying to fuse AI and robotics to create an intelligence that can make decisions and control a physical body in the messy, unpredictable, and unforgiving real world." NANOTECH Microscopic Metaveh
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Weekend reads: Paper mill sanctions; UT Austin suspends prof, repays grant funds; researchers in Mexico threatened with arrest
Before we present this week's Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured: Researcher leaves Wistar Institute as he retracts a Nature paper … Continue reading
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Participants needed for an online psycholinguistic experiment
Hello, Keith is my name, and I am a PhD researcher at Maynooth University`s Department of Psychology in Ireland. I am looking for people to participate in a language-related experiment that is running online, which takes approximately 15 minutes to complete. The only criteria are that participants are aged between 18-55, speak English as a first language, and have no severe visual or neurological
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Get the Brain Boost You Need With an Advanced Acetylcholine Supplement
Even if you've never heard of acetylcholine before, you've still got it on your mind … literally. That's because it's a neurotransmitter that your brain needs to perform vital functions and mental processing. And if you've been feeling at all hazy or in need of a brain boost lately, an acetylcholine supplement like Natural Stacks's Acetylcholine Brain Food might be just the thing. Research on the
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Unprecedented view of a single catalyst nanoparticle at work
A research team has been using high-intensity X-rays to observe a single catalyst nanoparticle at work. The experiment has revealed for the first time how the chemical composition of the surface of an individual nanoparticle changes under reaction conditions, making it more active. This study marks an important step towards a better understanding of real, industrial catalytic materials.
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Melting Arctic Could Release Nuclear Waste and Deadly Pathogens, Scientists Say
Sealed Away As Arctic ice melts away, it will likely raise the sea level and contribute to the devastation of ecosystems around the world. But it can also release chemical and biological hazards that had been safely sealed away. Those hazards can include ancient or undiscovered viruses and bacteria, toxic chemicals, and even nuclear waste, according to research published in the journal Nature Cli
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This Amazing Blanket Lets You Say Goodbye to Bug Repellent Once and for All
Depending on where you live, one of the worst things about hanging out on the patio at dusk is getting eaten alive by mosquitos or other insects. Of course, you could use insect repellent to ward off pesky insects, but it probably wouldn't help your cause. That's because a new study in the Journal of Insect Science has found, "many of the products … tested that were marketed as repellents do not
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Field-theoretic density estimation for biological sequence space with applications to 5' splice site diversity and aneuploidy in cancer [Biophysics and Computational Biology]
Density estimation in sequence space is a fundamental problem in machine learning that is also of great importance in computational biology. Due to the discrete nature and large dimensionality of sequence space, how best to estimate such probability distributions from a sample of observed sequences remains unclear. One common strategy…
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Earth history events shaped the evolution of uneven biodiversity across tropical moist forests [Evolution]
Far from a uniform band, the biodiversity found across Earth's tropical moist forests varies widely between the high diversity of the Neotropics and Indomalaya and the relatively lower diversity of the Afrotropics. Explanations for this variation across different regions, the "pantropical diversity disparity" (PDD), remain contentious, due to difficulty teasing…
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The impact of social isolation and changes in work patterns on ongoing thought during the first COVID-19 lockdown in the United Kingdom [Psychological and Cognitive Sciences]
The COVID-19 pandemic led to lockdowns in countries across the world, changing the lives of billions of people. The United Kingdom's first national lockdown, for example, restricted people's ability to socialize and work. The current study examined how changes to socializing and working during this lockdown impacted ongoing thought patterns…
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Surface densities prewet a near-critical membrane [Biophysics and Computational Biology]
Recent work has highlighted roles for thermodynamic phase behavior in diverse cellular processes. Proteins and nucleic acids can phase separate into three-dimensional liquid droplets in the cytoplasm and nucleus and the plasma membrane of animal cells appears tuned close to a two-dimensional liquid–liquid critical point. In some examples, cytoplasmic proteins…
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Ultrasensitive multispecies spectroscopic breath analysis for real-time health monitoring and diagnostics [Physics]
Breath analysis enables rapid, noninvasive diagnostics, as well as long-term monitoring of human health, through the identification and quantification of exhaled biomarkers. Here, we demonstrate the remarkable capabilities of mid-infrared (mid-IR) cavity-enhanced direct-frequency comb spectroscopy (CE-DFCS) applied to breath analysis. We simultaneously detect and monitor as a function of time…
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Constitutive signal bias mediated by the human GHRHR splice variant 1 [Cell Biology]
Alternative splicing of G protein–coupled receptors has been observed, but their functions are largely unknown. Here, we report that a splice variant (SV1) of the human growth hormone–releasing hormone receptor (GHRHR) is capable of transducing biased signal. Differing only at the receptor N terminus, GHRHR predominantly activates Gs while SV1…
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Continuous measurements of volatile gases as detection of algae crop health [Agricultural Sciences]
Algae cultivation in open raceway ponds is considered the most economical method for photosynthetically producing biomass for biofuels, chemical feedstocks, and other high-value products. One of the primary challenges for open ponds is diminished biomass yields due to attack by grazers, competitors, and infectious organisms. Higher-frequency observations are needed for…
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Nanoconfinement of microvilli alters gene expression and boosts T cell activation [Biophysics and Computational Biology]
T cells sense and respond to their local environment at the nanoscale by forming small actin-rich protrusions, called microvilli, which play critical roles in signaling and antigen recognition, particularly at the interface with the antigen presenting cells. However, the mechanism by which microvilli contribute to cell signaling and activation is…
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Listeriolysin S: A bacteriocin from Listeria monocytogenes that induces membrane permeabilization in a contact-dependent manner [Microbiology]
Listeriolysin S (LLS) is a thiazole/oxazole–modified microcin (TOMM) produced by hypervirulent clones of Listeria monocytogenes. LLS targets specific gram-positive bacteria and modulates the host intestinal microbiota composition. To characterize the mechanism of LLS transfer to target bacteria and its bactericidal function, we first investigated its subcellular distribution in LLS-producer bacter
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Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2 [Neuroscience]
Circuit formation in the central nervous system has been historically studied during development, after which cell-autonomous and nonautonomous wiring factors inactivate. In principle, balanced reactivation of such factors could enable further wiring in adults, but their relative contributions may be circuit dependent and are largely unknown. Here, we investigated hippocampal…
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Neural mechanisms underlying the temporal control of sequential saccade planning in the frontal eye field [Neuroscience]
Sequences of saccadic eye movements are instrumental in navigating our visual environment. While neural activity has been shown to ramp up to a threshold before single saccades, the neural underpinnings of multiple saccades is unknown. To understand the neural control of saccade sequences, we recorded from the frontal eye field…
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Structural origins of Escherichia coli RNA polymerase open promoter complex stability [Biophysics and Computational Biology]
The first step in gene expression in all organisms requires opening the DNA duplex to expose one strand for templated RNA synthesis. In Escherichia coli, promoter DNA sequence fundamentally determines how fast the RNA polymerase (RNAP) forms "open" complexes (RPo), whether RPo persists for seconds or hours, and how quickly…
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Chirality-matched catalyst-controlled macrocyclization reactions [Chemistry]
Macrocycles, formally defined as compounds that contain a ring with 12 or more atoms, continue to attract great interest due to their important applications in physical, pharmacological, and environmental sciences. In syntheses of macrocyclic compounds, promoting intramolecular over intermolecular reactions in the ring-closing step is often a key challenge. Furthermore,…
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The hippocampus weaves memories into stories
A new brain imaging study shows that the hippocampus is the brain's storyteller, connecting separate, distant events into a single narrative. "Things that happen in real life don't always connect directly, but we can remember the details of each event better if they form a coherent narrative," says Brendan Cohn-Sheehy, an MD/PhD student at the University of California, Davis and first author of t
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Intel's Loihi: Cool Even If You're Not In the C-Suite
Several years ago, Intel unveiled Loihi, its first public neuromorphic research processor. The term "neuromorphic" is essentially a catch-all for any type of processor that attempts to mimic the function of the brain. Because the brain is a complex organism, different chips can be neuromorphic in different ways, depending on which aspect of the brain's design they attempt to copy. Now, Intel has
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Highly active engineered IgG3 antibodies against SARS-CoV-2 [Applied Biological Sciences]
Monoclonal antibodies (mAbs) that efficiently neutralize SARS-CoV-2 have been developed at an unprecedented speed. Notwithstanding, there is a vague understanding of the various Ab functions induced beyond antigen binding by the heavy-chain constant domain. To explore the diverse roles of Abs in SARS-CoV-2 immunity, we expressed a SARS-CoV-2 spike protein…
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Tweak amps up cancer immunotherapy by 77 fold
Researchers have developed a new nanoparticle to deliver intravenous cancer immunotherapy. Cancer immunotherapy seeks to turn "cold" tumors into "hot" tumors—those that respond to immunotherapy—by awakening and enlisting the body's own immune system. Unfortunately, few people benefit from the most common form of immunotherapy, called immune checkpoint inhibitors, and scientists are actively seeki
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What you need to know about urinary tract infections
More than half of U.S. women will experience at least one urinary tract infection (UTI) in their lifetimes, while a quarter will have a subsequent infection. Recurrent urinary tract infections are defined as two or more infections in six months or three or more in a year.
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Can food ease symptoms for people with bipolar disorders?
Can specific dietary guidelines help people living with bipolar disorders better manage their health? Maybe someday, according to a new study. Clinical trial results show that a diet designed to alter levels of specific fatty acids consumed by participants may help patients have less variability in their mood. Bipolar disorders, which affect up to 2.4% of the population, are mental health conditi
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Powerful technique details brain tumors' formidable resiliency
A team led by researchers has profiled in unprecedented detail thousands of individual cells sampled from patients' brain tumors. The findings, along with the methods developed to obtain those findings, represent a significant advance in cancer research, and ultimately may lead to better ways of detecting, monitoring and treating cancers.
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