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'Astounding' Roman statues unearthed at Norman church ruins on route of HS2
Heads of man, woman and child found on site of Stoke Mandeville church built in 1080 and abandoned 800 years later Roman statues of a man, woman and child have been uncovered by archaeologists at an abandoned medieval church on the route of the HS2 high-speed railway. The discovery was "utterly astounding", according to Rachel Wood, the lead archaeologist at the site in Stoke Mandeville, Buckingh
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Australia live Covid news update: NSW records 236 new cases and three deaths; crowds to test eased Melbourne restrictions
Melbourne and Victoria's regions reunited and major events to be held at Flemington Racecourse and Sidney Myer Music Bowl Victorian Covid restrictions: what rules and regulations have changed? Vaccine rollout tracker ; cases and data tracker Biden admits to Macron the US was 'clumsy' in Aukus submarine deal Get our free news app ; get our morning email briefing There have been 236 new locally-acq
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Is it worth trying to sway the most staunch climate deniers?
Thanks to algorithms that learn about social media users' content preferences, Facebook timelines, Twitter feeds, suggested YouTube videos, and other news streams can look startlingly different from one person's online account to the next. Media and communication experts often wrestle with how to rein in the forces that further polarize people with different views, especially people who sit on opp
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Morro Bay seagrass loss causes change in fish populations
The loss of seagrass habitat caused a dramatic shift in fish species in Morro Bay. Areas once covered with lush seagrass meadows and unique fish species are now home to muddy-seafloor-loving flatfish, according to a paper by Cal Poly researchers published in the October 2021 print edition of Estuaries and Coasts.
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This squirrel watches its neighbor's back
Unlike meerkats that take individual turns watching for predators while the rest forage, Barbary ground squirrels found off the coast of Africa stand sentry together — a behavior called synchronous vigilance, according to a new study.
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Harvard Student Strike a Warning to University
Graduate students planned a three-day-long strike to demand fair pay, union security, and improved protections against sexual harassment and discrimination. If an agreement isn't met, the union says they may strike longer, potentially disrupting university research.
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Play Hundreds Of Retro Video Games With 59% Off This Mini Gaming Console
These days, you can play modern video games in a car's dashboard , but it wasn't so long ago that video games were confined to huge bulky consoles in the den. If you're missing that feeling of playing a 2D classic on the rug downstairs, the Mini Game Entertainment System with 620 Built-In Classic Games brings back that feeling, in a much smaller package. The Feeling You Remember As you can see ab
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Man Who Coined the Term "Cyberspace" Says He Can't Send Emails
Emailmancer Influential sci-fi author William Gibson, widely credited with coining the term "cyberspace" and imagining an ahead-of-its time vision of the internet back in his 1984 novel "Neuromancer," is having computer trouble. "Current contact info," he tweeted today . "If you email me, I receive it, but a glitch is making it impossible for me to email you my reply. If you text me at my usual n
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Innovative chip resolves quantum headache
Quantum physicists are reporting an international achievement for Denmark in the field of quantum technology. By simultaneously operating multiple spin qubits on the same quantum chip, they surmounted a key obstacle on the road to the supercomputer of the future. The result bodes well for the use of semiconductor materials as a platform for solid-state quantum computers.
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Drones show promise in speeding up communication with underwater robots for ocean surveys
Researchers have investigated the performance capability of unmanned aerial vehicles (UAVs) as a communication platform with autonomous underwater vehicles (AUVs) for ocean and seafloor monitoring research. Studies suggest that UAVs exhibit suitable communication performance for underwater measurement up to approximately 1 km from the shore, owing to their operation speed, robust hovering control,
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Two provably consistent divide-and-conquer clustering algorithms for large networks [Applied Mathematics]
In this article, we advance divide-and-conquer strategies for solving the community detection problem in networks. We propose two algorithms that perform clustering on several small subgraphs and finally patch the results into a single clustering. The main advantage of these algorithms is that they significantly bring down the computational cost…
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MDM2, MDMX, and p73 regulate cell-cycle progression in the absence of wild-type p53 [Cell Biology]
The p53 tumor suppressor protein, known to be critically important in several processes including cell-cycle arrest and apoptosis, is highly regulated by multiple mechanisms, most certifiably the Murine Double Minute 2–Murine Double Minute X (MDM2–MDMX) heterodimer. The role of MDM2–MDMX in cell-cycle regulation through inhibition of p53 has been well…
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Power spectra reveal distinct BOLD resting-state time courses in white matter [Neuroscience]
Accurate characterization of the time courses of blood-oxygen-level–dependent (BOLD) signal changes is crucial for the analysis and interpretation of functional MRI data. While several studies have shown that white matter (WM) exhibits distinct BOLD responses evoked by tasks, there have been no comprehensive investigations into the time courses of spontaneous…
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Yersiniabactin contributes to overcoming zinc restriction during Yersinia pestis infection of mammalian and insect hosts [Microbiology]
Yersinia pestis causes human plague and colonizes both a mammalian host and a flea vector during its transmission cycle. A key barrier to bacterial infection is the host's ability to actively sequester key biometals (e.g., iron, zinc, and manganese) required for bacterial growth. This is referred to as nutritional immunity….
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SARS-CoV-2 evolution in animals suggests mechanisms for rapid variant selection [Microbiology]
SARS-CoV-2 spillback from humans into domestic and wild animals has been well documented, and an accumulating number of studies illustrate that human-to-animal transmission is widespread in cats, mink, deer, and other species. Experimental inoculations of cats, mink, and ferrets have perpetuated transmission cycles. We sequenced full genomes of Vero cell–expanded…
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Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics [Microbiology]
Bacterial cell wall peptidoglycan is essential, maintaining both cellular integrity and morphology, in the face of internal turgor pressure. Peptidoglycan synthesis is important, as it is targeted by cell wall antibiotics, including methicillin and vancomycin. Here, we have used the major human pathogen Staphylococcus aureus to elucidate both the cell…
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Mammalian sperm hyperactivation regulates navigation via physical boundaries and promotes pseudo-chemotaxis [Developmental Biology]
Mammalian sperm migration within the complex and dynamic environment of the female reproductive tract toward the fertilization site requires navigational mechanisms, through which sperm respond to the tract environment and maintain the appropriate swimming behavior. In the oviduct (fallopian tube), sperm undergo a process called "hyperactivation," which involves switching from…
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Fevers and the social costs of acute infection in wild vervet monkeys [Environmental Sciences]
Fevers are considered an adaptive response by the host to infection. For gregarious animals, however, fever and the associated sickness behaviors may signal a temporary loss of capacity, offering other group members competitive opportunities. We implanted wild vervet monkeys (Chlorocebus pygerythrus) with miniature data loggers to obtain continuous measurements of…
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Serum apolipoprotein A-I depletion is causative to silica nanoparticles-induced cardiovascular damage [Environmental Sciences]
The rapid development of nanotechnology has greatly benefited modern science and engineering and also led to an increased environmental exposure to nanoparticles (NPs). While recent research has established a correlation between the exposure of NPs and cardiovascular diseases, the intrinsic mechanisms of such a connection remain unclear. Inhaled NPs can…
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Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating [Biochemistry]
The human ERG (hERG) K+ channel has a crucial function in cardiac repolarization, and mutations or channel block can give rise to long QT syndrome and catastrophic ventricular arrhythmias. The cytosolic assembly formed by the Per-Arnt-Sim (PAS) and cyclic nucleotide binding homology (CNBh) domains is the defining structural feature of…
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Configurational fingerprints of multicellular living systems [Biophysics and Computational Biology]
Cells cooperate as groups to achieve structure and function at the tissue level, during which specific material characteristics emerge. Analogous to phase transitions in classical physics, transformations in the material characteristics of multicellular assemblies are essential for a variety of vital processes including morphogenesis, wound healing, and cancer. In this…
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Live agent preference and social action monitoring in the macaque mid-superior temporal sulcus region [Neuroscience]
Mentalizing, the ability to infer the mental states of others, is a cornerstone of adaptive social intelligence. While functional brain mapping of human mentalizing has progressed considerably, its evolutionary signature in nonhuman primates remains debated. The discovery that the middle part of the macaque superior temporal sulcus (mid-STS) region has…
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Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors [Plant Biology]
Plants and animals use cell surface receptors to sense and interpret environmental signals. In legume symbiosis with nitrogen-fixing bacteria, the specific recognition of bacterial lipochitooligosaccharide (LCO) signals by single-pass transmembrane receptor kinases determines compatibility. Here, we determine the structural basis for LCO perception from the crystal structures of two lysin…
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The middle cingulate cortex and dorso-central insula: A mirror circuit encoding observation and execution of vitality forms [Psychological and Cognitive Sciences]
Actions with identical goals can be executed in different ways (gentle, rude, vigorous, etc.), which D. N. Stern called vitality forms [D. N. Stern, Forms of Vitality Exploring Dynamic Experience in Psychology, Arts, Psychotherapy, and Development (2010)]. Vitality forms express the agent's attitudes toward others. In a series of fMRI…
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Accurate model of liquid-liquid phase behavior of intrinsically disordered proteins from optimization of single-chain properties [Biophysics and Computational Biology]
Many intrinsically disordered proteins (IDPs) may undergo liquid–liquid phase separation (LLPS) and participate in the formation of membraneless organelles in the cell, thereby contributing to the regulation and compartmentalization of intracellular biochemical reactions. The phase behavior of IDPs is sequence dependent, and its investigation through molecular simulations requires protein models..
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Flexible complementary circuits operating at sub-0.5 V via hybrid organic-inorganic electrolyte-gated transistors [Chemistry]
Electrolyte-gated transistors (EGTs) hold great promise for next-generation printed logic circuitry, biocompatible integrated sensors, and neuromorphic devices. However, EGT-based complementary circuits with high voltage gain and ultralow driving voltage (<0.5 V) are currently unrealized, because achieving balanced electrical output for both the p- and n-type EGT components has not been…
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Phase separation in the outer membrane of Escherichia coli [Biophysics and Computational Biology]
Gram-negative bacteria are surrounded by a protective outer membrane (OM) with phospholipids in its inner leaflet and lipopolysaccharides (LPS) in its outer leaflet. The OM is also populated with many β-barrel outer-membrane proteins (OMPs), some of which have been shown to cluster into supramolecular assemblies. However, it remains unknown how…
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Concept2 RowErg review
Robust and reliable, the Concept2 RowErg (formerly called the Concept2 Model D) deserves its reputation as one of the world's most popular rowing machines
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Best All-in-One Printer to Meet Your Work-From-Home Needs
If you're working from a home office or, well, an office-office, a printer is still a must-buy gadget. While 3D printers offer more creative possibility, all-in-one printers are a great blend of form and functionality, as a printer, scanner, copier, and sometimes a fax into one device. All-in-one printers are typically either use inkjet or laser technology, with the addition of a copier/scanner o
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Linking the past and present: Reconstructing the dragonfly and damselfly family tree
Researchers used transcriptomics (a type of gene sequencing) calibrated using information from the fossil record to create the first phylogenetic reconstruction of the insect order Odonata (dragonflies and damselflies), covering 105 species. This reconstruction of the evolutionary history allowed robust estimations of the species divergence time (or first appearance, around 200 million years ago)
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Abdul Qadeer Khan (1936–2021)
Nature, Published online: 29 October 2021; doi:10.1038/d41586-021-02997-3 Materials scientist behind Pakistan's nuclear-weapons business.
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Blasting the 'zombie' out of water-saving tech
Scientists suggest that reliance on modern irrigation technologies as a water-use efficiency strategy is a 'zombie idea' — one that persists no matter how much evidence is thrown against it. Technology adoption as a water-saving method for improving irrigation efficiency is ineffective, and can actually worsen water scarcity, according to researchers.
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Inflation uncertainty highest in four decades
Consumer sentiment has remained virtually unchanged in the past three months, at levels comparable to the pandemic low point in April 2020, according to the University of Michigan Surveys of Consumers.
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World Bank report recognises importance of measurement beyond GDP
The World Bank's flagship report, The Changing Wealth of Nations/ for the first time emphasizes the importance of social capital to sustainability. By including the role of trust, social norms and community cohesiveness in securing a sustainable future, it represents a major advance in the international effort to go beyond GDP for the measurement of progress.
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California lawmakers call for changes after Orange County oil spill
Weeks after a massive oil spill marred the Orange County coast with significant environmental and economic damage, state lawmakers met in Sacramento on Thursday to demand that those responsible "be held accountable," with one legislator calling for an end to offshore drilling in California.
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Unlocking molecular shape puzzles to build better chemosensors
We live in times when technology has become a regular part of our lives. Besides many portable devices, smartphones or wrist-worn fitness trackers are equipped with sensors to measure health parameters like pulse or blood saturation with oxygen. The appearance of such devices on the market made our lives easier. It revolutionized medicine, enabling us to check even the glucose level at home.
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Drug-like molecule points to novel strategies for cancer therapy
A decade ago, genome sequencing revealed a big surprise: about 50 percent of human cancers are linked to mutations in what are known as epigenetic regulators, which control the activity of genes. Medical researchers have now developed a new drug-like molecule that can counteract the effects of mutated epigenetic regulators, which are known to drive certain types of cancer including lymphoma.
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Sparring Over Fauci Turns to Puppies
Right-wing backlash against National Institute of Allergy and Infectious Diseases head Anthony Fauci intensified this week over an unexpected issue: beagle puppies. The dispute was sparked last Friday by a letter to Fauci from a bipartisan group of legislators, who criticized NIAID for using dogs in research.
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Horse riding confirmed as a viable mobility treatment for cerebral palsy
Cerebral palsy (CP) affects around two out of every 1000 children born worldwide. Physical therapy is the foremost way of improving movement, balance, and posture in children with CP. Research has shown that hippotherapy, a form of physical therapy involving horse riding, is effective for treating CP. But how exactly does it help? In a recent study, researchers explore this question and provide in
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New speed record set for measurements of water-air flows
For the first time, researchers at D-BAUG have measured air-water flows with velocities exceeding 40 m/s. To this end, two challenging measurement campaigns were carried out in the tunnel spillway of a 225 m high dam, for which special probes first had to be developed. With the new data, existing design guidelines can be validated, and so-called scale effects can be assessed more accurately. This
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The goal in mind
Scientists discover the brain's internal goal map enabling animals to navigate precisely to a chosen destination.
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The early bird gets…the truffle? Birds hunt for fungi, too
Scientists used to think that only mammals sought out truffles, but a new study shows that birds also pursue these underground fungi. The researchers collected the feces of two common ground-dwelling bird species in Patagonia and found they contained truffle DNA and viable truffle spores. The spread of truffles is important to the health of forest ecosystems, where truffle species and other mycorr
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Lifting the veil over mysterious desert truffles: Terfezia's ecology and diversity towards cultivation
Developing below the soil surface, desert truffles are hard to find. Recently, researchers updated the number of known species of the desert truffle genus Terfezia occurring in Portugal from three to ten species. They thoroughly characterized their ecological preferences, adding new knowledge on Terfezia's cryptic lifestyle. These findings are of major importance, as desert truffles have a high ec
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Behavioral synchronization in complex societies of feral horses
Scientists used a drone and a multi-agent computerized system for complex social structure modeling to test, for example, whether individuals in a herd of feral horses synchronize according to their social network. For this hypothesis, two sub-models were created, one of which only takes into an account the same unit group members. The other sub-model applies to the entire herd. The simulation and
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A new perspective on the journey to net-zero | Amina J. Mohammed
Climate action can be a vehicle to deliver dignity, opportunity and equality for all. UN Deputy Secretary-General Amina J. Mohammed invites us to reimagine what the journey to net-zero could look like if we invest in people's climate efforts while prioritizing the 17 Sustainable Development Goals — a blueprint of interlinked global goals to protect humanity and our warming planet. "It's time to m
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Journal study suggests forcing open peer review could lead to more bias
An entomologist at the University of Kentucky has found that requiring peer review reviewers to sign their names to their review comments could bias their results. In his paper published in Proceedings of the Royal Society B: Biological Sciences, Charles Fox, describe how he studied peer-reviewed articles for one prominent journal and what he learned about the process.
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Assembling materials using charged polymers
Soft matter can be found in many everyday materials, such as food, cosmetics, and the cells in our own bodies. The structure of these tiny, soft materials is determined by various interactions, one of which is electrostatic interaction. For his Ph.D. research, Christian Sproncken used electrostatic interactions to assemble soft materials into various structures consisting of charged polymer chains
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Runoff, sediment flux in High Mountain Asia could limit food, energy for millions
Rivers flowing from the Tibetan Plateau and the surrounding high Asian mountains which support one-third of the world's population have experienced rapid increases in annual water and sediment runoff since the 1990s, and the volume of sediment washed downstream could more than double by 2050 under the worst-case scenario, a team of scientists has found.
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A novel way to generate visible light
Visible light is extremely important in nature. Seen by the human eye, it is the most intense light emitted by the sun to reach the earth's surface and is an essential element for fundamental biological processes underlying life. However, it is difficult to generate coherent visible light, like the light of a laser, that is intense for a short amount of time, in the order of the femtosecond.
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Keller Rinaudo: How can delivery drones save lives?
In rural areas, basic health care can be out of reach. Keller Rinaudo founded Zipline, a delivery company that uses drones to deliver necessary medical supplies within hours, even minutes. (Image credit: Ryan Lash/Ryan Lash / TED)
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Integrated edge localized mode suppression and divertor power flux control for ITER
Using Resonant Magnetic Perturbations (RMP), researchers led by Prof. Sun Youwen from the Institute of Plasma Physics of the Chinese Academy of Sciences took the lead in demonstrating the integrated Edge Localized Mode (ELM) and divertor power flux control in target plasmas with parameters close to International Thermonuclear Experimental Reactor (ITER) high fusion gain (Q) operation.
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Severe heatwaves on the rise
Extreme heatwaves that may have happened once every decade are in danger of becoming an annual occurrence unless steps are taken to address climate change, a study suggests.
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Jumping out of a Plane with DB Cooper's Parachute | Expedition Unknown
Stream Expedition Unknown on discovery+ ► https://www.discoveryplus.com/show/expedition-unknown #Discovery #ExpeditionUnknown #DBCooper Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitter.com/D
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Extremt mansideal bakom gängvåldet
En stark maskulinitet där vapen och våld romantiseras är vanligt i kriminella gäng. Men ofta är denna machokultur en kompensation för ett tidigt utanförskap. Att jobba med manlig identitet kan vara en del av lösningen. Bilderna är medvetet förnedrande. Den unge mannen sitter på golvet i en lägenhet påtvingad typiska "kvinnokläder". Det var i april 2020 som rapparen Nils Grönberg, med artistnamnet
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COVID lockdowns gave some teen girls a break from stress
While lockdowns in the early days of the COVID-19 pandemic were challenging for teen girls' mental health, they also offered a respite from their packed everyday lives. That's a warning sign for how stressful the lives of teens have become, researchers say. Even before the pandemic, experts sounded the alarm about teen mental health. "Over the last decade, we've been seeing these really skyrocket
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When just a few termites take the bait, it kills the whole colony
Less is more when it comes to just how many subterranean termites have to eat a chemical known as a chitin synthesis inhibitor before the entire colony is eliminated, a study of 1.68 million termites shows. For the study, which appears in the Journal of Pest Science , researchers took a closer look at how much bait it takes to eliminate a subterranean colony. As a prominent industry standard used
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Facebook Teases New High-End 'Project Cambria' VR Headset
Facebook's current Oculus headsets clock in at much lower prices than the headsets of yesteryear, and yet they're still impressive pieces of hardware. However, the social media giant is working on a headset that isn't going to compete on price. The company teased the upcoming Project Cambria VR headset at the Connect conference, saying it will be a high-end experience rather than a replacement fo
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EEG helps predict if treatment will benefit people with epilepsy
Combining electroencephalogram data with clinical observations can help doctors to better determine if generalized epilepsy patients will respond to treatment, according to a new study. For the study researchers used a new statistical model that is 80% accurate in distinguishing between drug-resistant and drug-responsive generalized epilepsy. "Traditionally, we had few tools available to help us
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Proposed Centaur mission could catch comets in the act of formation
From Mercury to the depths of the distant Kuiper Belt, there aren't many unexplored corners of the solar system out there. One class of object, however, remains to be visited: the transitional Centaurs out beyond the orbit of Jupiter. Now, a new study from the University of Chicago recently accepted in The Planetary Science Journal looks at the feasibility of sending a mission by mid-century to in
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What Kind of Problem is Global Warming
Framing is important, and often exists below our conscious awareness. If we are not even aware that we are framing an issue in a certain way, and that other framings are possible, this will influence our thinking in ways that we cannot anticipate or correct for. Sometimes a particular framing is deliberate, a strategy for propaganda and rhetorical advantage. This is often done in order to win a d
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Studying Terfezia, the mysterious desert truffles, with an eye toward ecology and cultivation
In a caring, symbiotic relationship, mycorrhizal fungi live and feed in the roots of specific plants, while providing water and nutrients to their "companion." In arid and semi-arid environments, mycorrhization processes are essential to the survival of both plants and fungi. Moreover, the fungus' hyphal network, which spreads within the soil connecting several plant individuals, is of utmost impo
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How echolocation adapts to environments
Eran Amichai, a postdoctoral fellow in ecology, evolution, environment and society, studies how echolocation signals differ within a population of big brown bats. Amichai records echolocation signals to identify specific bats, and then films the individuals in a large chamber with open and wooded areas to see whether the unique sensory signals are optimized for open or wooded environments.
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Lithium metal batteries with diluted high concentration electrolytes to power the future
Researchers from Daegu Gyeongbuk Institute of Science and Technology investigate the impact of high concentration electrolyte (HCE) dilution on lithium metal battery (LMB) cycling over a wide temperature. Their comprehensive study reveals that dilution of HCE significantly improves Li+ ion transport at lower temperatures and thermal stability of solid-electrolyte interface at higher temperatures,
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Including small, sharp landscape contrasts refines weather forecasts
By leveraging a popular weather forecasting model, environmental engineers at Duke University have demonstrated that sharp contrasts in relatively small land features play an outsized role in local weather developments, which can in turn influence larger climate trends. The study indicates that the addition of such detailed data, which is currently overlooked in climate and weather forecast models
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Are you really smart, or is it just Google?
The ability to quickly google the answer to just about any question changes how people perceive their own intelligence, research finds. People lose sight of where their memory ends and where the internet begins, the findings indicate. "When we're constantly connected to knowledge, the boundaries between internal and external knowledge begin to blur and fade," says Adrian Ward, assistant professor
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Beware of rainbows
Nature, Published online: 29 October 2021; doi:10.1038/d41586-021-02961-1 The sacred and profane.
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Färre resistenta tarmbakterier med bortglömt antibiotikum
Ett bortglömt antibiotikum, temocillin, gav färre resistenta tarmbakterier jämfört med standardbehandling mot urinvägsinfektion med feber. Temocillin kan vara ett bra alternativ för behandling vid svår urinvägsinfektion och bidra till minskad spridning av resistenta bakterier på sjukhus. Den kliniska effekten var lika bra för temocillin som för standardbehandlingen med cefotaxim, och även biverkn
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The importance of electrode interfaces and interphases for rechargeable metal batteries
Nature Communications, Published online: 29 October 2021; doi:10.1038/s41467-021-26481-8 Metal electrode interfaces and interphases are critical for the development of future high-energy metal batteries. Here, Dr Jelena Popovic-Neuber discusses the state of the art, issues and strategies to improve the stability of metal electrodes toward practical battery systems.
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Magnetic memory driven by topological insulators
Nature Communications, Published online: 29 October 2021; doi:10.1038/s41467-021-26478-3 It remains challenging to integrate topological insulators (TI) with magnetic tunnel junctions (MTJ) for spintronics applications. Here, the authors achieve a large tunneling magnetoresistance ratio and a low switching current density in a TI-MTJ device at room temperature, very promising for TI-driven magnet
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Normal & reversed spin mobility in a diradical by electron-vibration coupling
Nature Communications, Published online: 29 October 2021; doi:10.1038/s41467-021-26368-8 In this manuscript, Negri, Zheng, Casado et al develop a stable and flexible diradical. Using a combination of experimental and theoretical techniques, they show how heating leads to change in the electronic and spin delocalizations ocurring between quinoidal and aromatic forms, and elucidate a unique spin-vi
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Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
Nature Communications, Published online: 29 October 2021; doi:10.1038/s41467-021-26519-x Whether microglial activation constitutes a primary pathological event in synucleinopathies is not known. Here, the authors generated a mouse model over-expressing α-synuclein in microglial cells and found these mice developed progressive dopaminergic neuron degeneration and microglia developed a reactive, pr
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Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse
Nature Communications, Published online: 29 October 2021; doi:10.1038/s41467-021-26489-0 Biomarkers of prostate cancer metastasis have been difficult to determine with confidence. Here the authors analyse mutation prevalence in 1844 prostate cancers and show that ZNRF3 loss is enriched in metastatic, castration-resistant prostate cancer and associated with metastasis of localized disease.
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Book Excerpt: Sounding the First Alarm on Covid-19
Shanghai scientist Zhang Yongzhen faced an agonizing decision after his team mapped the genome of a mysterious new coronavirus from Wuhan. Each day the genetic information wasn't publicly available meant another day before tests for the infection could be developed, potentially jeopardizing global health.
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Scientists join international push to ban harmful fisheries subsidies
Three hundred scientists from 255 institutions in 46 countries, including Professor Dirk Zeller and Ph.D. candidate Lincoln Hood from The University of Western Australia, are asking members of the World Trade Organization (WTO) to ban harmful fisheries subsidies at the 12th Ministerial Conference to be held in Geneva, Switzerland next month.
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Hjemmetræning har positiv effekt for lungepatienter
Når personer med lungesygdomme træner i og omkring eget hjem, har det en positiv effekt, viser statusartikel. Reservelæge håber, at hjemmetræning kan være et tilbud til dem, der ikke er interesseret eller er forhindret i at deltage i strukturel rehabilitering.
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Retspsykiatriske patienter får helende omgivelser
Det har været mere end ti år undervejs, men nu står den fysiske fremtid for retspsykiatrien i Roskilde klar, og i løbet af november flytter patienter fra det gamle Sct. Hans og Glostrup retspsykiatri ind i nybyggede omgivelser. Nybyggeriet skal blandt andet give bedre mulighed for rehabilitering og for at have en meningsfyldt hverdag under opholdet. Håbet er, at det betyder hurtigere bedring og k
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Schneider Shorts 29.10.2021 – Down by Law
Schneider Shorts 29.10.2021 – fluvoxamine officially a COVID-19 game-changer, lab leak still just a conspiracy theory, Retraction Watchdogs catch a cheating student, papermill customers get sanctioned, and lawsuits everywhere: Sabatini sues Whitehead, Macchiarini trial begins in Sweden, Athira Pharma separates from cheating CEO while facing investor lawsuits, and Raoult finally facing criminal cha
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Glansbilledet af Doktor Hansen krakelerer
LEDER: Det er oplagt at spørge, hvor solidariteten er henne hos alle dem, der hylder glansbilledet af familielægen? Solidariteten med patienterne og med de læger, der skal dække de mindre attraktive områder?
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Topdirektører fra Roche og Biogen: Vi har brug for en ny demenshandlingsplan
DEBAT: Det går ikke godt nok på demensområdet. Hverken i forhold til opsporing, diagnosticering eller behandling. Så hvad sker der, når der i fremtiden kommer 50 pct. flere patienter med en demenssygdom? Der er behov for en ny handlingsplan for demens, så vi sammen kan håndtere udfordringerne, skriver de to adm. direktører for hhv. Roche Pharmaceuticals i Danmark og Biogen i et fælles debatindlæg.
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The search for people who never get COVID
Nature, Published online: 29 October 2021; doi:10.1038/d41586-021-02978-6 An international team of researchers wants to find people who are genetically resistant to SARS-CoV-2, in the hope of developing new drugs and treatments.
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Microorganisms produce elemental carbon
Carbon occurs on the Earth in a variety of structures and forms. Elemental Carbon is usually formed under conditions of high pressure and temperature. Researchers have now, for the first time, identified microorganisms that produce elemental carbon.
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Unlocking the technology to produce unbreakable screens
Cracked phone screens could become a thing of the past thanks to breakthrough research The researchers have unlocked the technology to produce next-generation composite glass for lighting LEDs and smartphone, television and computer screens. The findings will enable the manufacture of glass screens that are not only unbreakable but also deliver crystal clear image quality.
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How legumes give oxygen to symbiotic bacteria in their roots
Scientists discover the genetics inside legumes that control the production of an oxygen-carrying molecule, crucial to the plant's close relationships with nitrogen-fixing bacteria. The finding offers the potential to give other plants the ability to produce ammonia from bacteria — reducing the need for the fossil fuel-dependent and polluting practice of applying synthetic fertiliser to crops.
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Warming climate will increase number of harmful algae blooms
A new study shows how changes in light conditions have a significant influence on the growth and impact of harmful algae blooms. The bottom line: a warming climate looks good for the growth of toxic algae and may disrupt other organisms that are part of the food web — whether they graze on this algae or are consumed by it.
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Technology's impact on worker well-being
In the traditional narrative of the evolving 21st century workplace, technological substitution of human employees is treated as a serious concern, while technological complementarity — the use of automation and artificial intelligence to complement workers — is viewed as a good thing. But a new study tells a more nuanced story, demonstrating that the integration of automation and AI in the work
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NASA Employee Says SpaceX's Starship Is About to Change Everything
NASA Jet Propulsion Lab system architect Casey Handmer is impressed with SpaceX's progress toward developing a rocket capable of sending astronauts to the Moon and even Mars. "Two years ago Starship was a design concept and a mock up," Handmer wrote in a lengthy post on his personal blog about the hyper-ambitious rocket. "Today it's a 95 percent complete prototype that will soon fly to space and
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NASA Wants Your Help Improving Perseverance Rover's AI
NASA's Perseverance rover is the most advanced machine ever sent to the red planet with a boatload of cameras and a refined design that should stand the test of time. Still, it's just a robot, and sometimes human intuition can help a robot smarten up. If you're interested in helping out, NASA is calling on any interested humans to contribute to the machine learning algorithms that help Perseveran
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