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Hugh Laurie, Who Played Dr. House, Appears to Have Just Brutally Roasted Anti-Vaxxers
Hugh Laurie, the actor best known from hit TV drama "House MD," took to Twitter today to absolutely roast the anti-vaccination movement — or, at least, we're pretty sure he did. "I find the injunction 'think for yourself' very stirring — until I remember that I could never have conceived of 99 percent of the concepts I rely on every day to survive," a contemplative Laurie wrote . "I'm extremely g
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Researchers reconstruct major branches in the tree of language
The diversity of human languages can be likened to branches on a tree. If you're reading this in English, you're on a branch that traces back to a common ancestor with Scots, which traces back to a more distant ancestor that split off into German and Dutch. Moving further in, there's the European branch that gave rise to Germanic; Celtic; Albanian; the Slavic languages; the Romance languages like
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NSW Covid crisis: Brad Hazzard defends end to daily press conferences as cases and death toll worsen
NSW records 1,599 new coronavirus cases and eight more deaths, while ACT chief minister Andrew Barr reports 15 new infections Follow the Australian Covid blog Qld Covid update: five new cases as Annastacia Palaszczuk flags possible lockdown Restrictions: NSW ; Vic ; borders NSW Covid vaccination rate by postcode – check your suburb Vaccine rollout tracker ; get our free news app ; get our morning
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Genetics Papers Retracted Over Human Experimentation Scandal
Two genetics papers that had been published in prominent academic journals have been retracted in response to criticism that their subjects — persecuted Muslim Uyghurs from China — hadn't fully consented to the process. The studies reveal a bleak trend in which members of Chinese law enforcement or public security officials are listed as coauthors on genetics research papers, suggesting that the
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Virgin Galactic Dumped $500 Million in Stocks Before Bad News Dropped
Pilots in control of the suborbital plane that took Virgin Galactic founder Richard Branson high into the upper atmosphere earlier this summer had to make a split second decision. A beeping red light alerted them to a deviation of their planned trajectory, but they forged ahead at three times the sound of speed. As revealed in a New Yorker piece several weeks later, the flight did not go entirely
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SpaceX Space Tourists Say Elon Musk Has Barely Talked to Them
Cerebral Guy It's set up to be a historic moment: a crew of four civilians are about to rocket into space on board a SpaceX Crew Dragon capsule. The launch, dubbed Inspiration4, could soon mark the first time an all-non-professional team has ever gone for a trip around the Earth. Interestingly, SpaceX CEO Elon Musk isn't exactly basking in the limelight ahead of Wednesday's launch. According to I
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Don't Believe the Salad Millionaire
Jonathan Neman really seemed to think he was onto something. Last week, in a lengthy, now-deleted post on LinkedIn, the CEO and co-founder of the upscale salad chain Sweetgreen expounded on a topic that might seem a little far afield for a restaurant executive: how to end the pandemic. "No vaccine nor mask will save us," he wrote. (The vaccines, it should be noted, have so far proved to be near-m
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What Is Larry Elder Running For?
Larry Elder becoming governor of California would be a little like Bernie Sanders winning a Senate seat in Kansas, or Alexandria Ocasio-Cortez representing suburban Mississippi in the House, or Mike Pence ending his career as the mayor of Portland, Oregon. Yet in less than a week's time, there's some chance, albeit a diminishing one, that it might happen. Elder, a conservative talk-radio host fro
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A decade after she died, I can finally grieve the Amy Winehouse I knew and loved
Coming to terms with the loss of my friend Amy Winehouse, amid the media frenzy that surrounded her death, has taken me 10 years God knows what I must have looked like: a bedraggled 25-year-old dressed as a psychedelic game hunter with glitter smeared across my face crying hysterically in a Cambridgeshire field. It was 4pm on 23 July 2011, and a friend of mine had broken the news to me: Amy was de
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It Worked! NASA's Mars Rover Definitely Scooped up Rock Samples This Time
Mission Complete Huge news: NASA confirmed that its Mars-rock-scooping robot, Perseverance, has at long last managed to scoop up some Mars rocks. That also means that the rover has started to conduct some rudimentary geological research on its surroundings, according to a NASA press release . While the bulk of the study will be conducted once those and any future samples make their way back to Ea
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America Played Into Al-Qaeda's Hands
Alex Majoli / Magnum The United States today does not have so much as an embassy in Afghanistan, Iran, Libya, Syria, or Yemen. It demonstrably has little influence over nominal allies such as Pakistan, which has been aiding the Taliban for decades, and Saudi Arabia, which has prolonged the conflict in Yemen . In Iraq, where almost 5,000 U.S. and allied troops have died since 2003, America must en
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Image: Hubble captures a sparkling cluster
This star-studded image from the NASA/ESA Hubble Space Telescope depicts NGC 6717, which lies more than 20,000 light-years from Earth in the constellation Sagittarius. NGC 6717 is a globular cluster, a roughly spherical collection of stars tightly bound together by gravity. Globular clusters contain more stars in their centers than their outer fringes, as this image aptly demonstrates; the sparsel
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The Atlantic Daily: The Roe v. Wade Baby Tells Her Story
Every weekday evening, our editors guide you through the biggest stories of the day, help you discover new ideas, and surprise you with moments of delight. Subscribe to get this delivered to your inbox. Tracy Nguyen for The Atlantic In 1973, American women won the constitutional right to abortion through Roe v. Wade . But the Supreme Court's ruling did not come in time for its anonymous plaintiff
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The Third Revolution in Warfare
On the 20th anniversary of 9/11, against the backdrop of the rushed U.S.-allied Afghanistan withdrawal, the grisly reality of armed combat and the challenge posed by asymmetric suicide terror attacks grow harder to ignore. But weapons technology has changed substantially over the past two decades. And thinking ahead to the not-so-distant future, we must ask: What if these assailants were able to
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SpaceX Tourist Spacecraft Will Be Loaded With Dozens of NFTs
Easy Lift Next week, the Inspiration4 mission, an all-civilian crew of space tourists, will careen into space on board a SpaceX Crew Dragon module. And flying with them will be dozens of non-fungible tokens (NFTs), according to Space.com , in an attempt to raise money for charity by capitalizing on the trendy digital certifications of authentication being bought, sold, and traded over the blockch
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A year that changed the world – and medical companies' fortunes
While Covid sent many firms to the wall, others prospered by spotting opportunities, from test kits to mask coatings The pandemic has taken a heavy toll on business, gutting high streets as familiar names fell into receivership. But for some less well-known firms, the past 18 months have been transformational. Those that have thrived did so by carving out a new niche – with products as varied as
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Sophia the Robot will be mass-produced this year
This article was originally published on our sister site, Freethink. When Sophia the robot debuted in 2016, she was one of a kind. She had a remarkably lifelike appearance and demeanor for a robot, and her ability to interact with people was unlike anything most had ever seen in a machine. Since then, Sophia has spoken to audiences across the globe (in multiple languages), been interviewed on cou
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The Atlantic Daily: 20 Years of Grief
Tomorrow marks 20 years since the attacks on September 11, 2001. The adrenaline shock of that morning has long worn off, leaving behind only the horror, the loss, and two decades' worth of grief. It's tempting to use this anniversary to consider the attacks as a greater political or cultural moment, to analyze where the country went right or wrong in its response. And doing so is important. But f
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This Modern Online Therapy Provider Will Help You Find Your Inner Calm
Outmoded social taboos notwithstanding, it's now a matter of common sense that mental health is just as vital and important to a person's wellbeing as physical health. But even though most of us know this to be true, it's still not easy to find a good mental health therapist, and the obstacles to finding one remain stubbornly high. And if you have a medical condition or some other reason for not
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First 10 Minutes of Season 1 | Gold Rush: Winter's Fortune
Stream Full Episodes of Gold Rush: discovery+ ► https://www.discoveryplus.com/show/gold-rush #Discovery #GoldRush #GoldRushWintersFortune Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitter.com
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This Week's Awesome Tech Stories From Around the Web (Through September 11)
LONGEVITY Meet Altos Labs, Silicon Valley's Latest Wild Bet on Living Forever Antonio Regalado | MIT Technology Review "Altos is pursuing biological reprogramming technology, a way to rejuvenate cells in the lab that some scientists think could be extended to revitalize entire animal bodies, ultimately prolonging human life. …The new company…is recruiting a large cadre of university scientists wi
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Twenty years after 9/11, hindsight is 20/20
The 20th anniversary of 9/11 arrives with pessimism and a sense of defeat. 9/11 caused a national trauma that lasted for years. We should remember this when analyzing the mistakes that America made in its war on terrorism during the subsequent 20 years. As the 20th anniversary of the 9/11 terrorist attack approached, I was disappointed to see how negative the media coverage is. The overall report
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The term 'AI' overpromises: Here's how to make it work for humans instead
One of the popular memes in literature, movies and tech journalism is that man's creation will rise and destroy it. Lately, this has taken the form of a fear of AI becoming omnipotent, rising up and annihilating mankind. The economy has jumped on the AI bandwagon; for a certain period, if you did not have "AI" in your investor pitch, you could forget about funding. (Tip: If you are just using a G
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20 år sedan 11 september­attackerna
Idag, 11 september 2021, är det precis tjugo år sedan attackerna mot USA, iscensatta av terror­organisationen al Qaeda. Fyra passagerarplan kapades och användes som självmords­missiler mot mål i USA. De … Continued Inlägget dök först upp på Vetenskap och Folkbildning .
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Enzyme could be major driver of preeclampsia
A new study indicates that an enzyme called protein phosphatase 2 (PP2A) appears to be a major driver of preeclampsia, a dangerous pregnancy complication characterized by the development of high blood pressure and excess protein in the urine. The finding could lead to new treatments for preeclampsia other than premature delivery, which is often the only option.
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What the brain shows: The benefits of virtual reality in creative arts therapies
Researchers examined the differences in prefrontal cortex (PFC) activation between two distinct drawing tasks in virtual reality. Results of the study indicated significant differences between a rote tracing task and a creative self-expression task, with the rote tracing task showing an increase in PFC activity. It also showed there was reduced PFC activation for creative self-expressive tasks, in
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People with Parkinson's may benefit from seven walking strategies
Various strategies can help people with Parkinson's who have difficulty walking, but a new study finds that many people have never heard of or tried these strategies. The study also found that how well different compensation strategies worked depended on the context in which they were used, such as indoors versus outdoors, under time pressure or not.
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Potential indicator for obesity risk detected during sleep
Researchers have shown that people with inflexible metabolisms burn less fat at night than those with flexible metabolism. The team measured the respiratory quotient throughout the night and found that despite equal ages, BMIs, and amount of fat, people with inflexible metabolisms burned more carbohydrates and less fat than did people with flexible metabolisms. The higher sleep-time quotient could
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New study on COVID-19 vaccinations in the largest US cities finds stark inequities
In a study of the nine largest U.S. cities, researchers found stark racial, ethnic, and socioeconomic inequities in COVID-19 vaccination rates across neighborhoods. The study showed that high vaccination neighborhoods had more white residents, fewer people of color, higher incomes, and lower poverty rates. These high vaccination neighborhoods also had lower historical COVID-19 death rates, showing
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Transforming marine biodiversity discovery and monitoring
A new system for sampling fragments of DNA from marine organisms drifting in the ocean is set to create new opportunities for research on biodiversity and ways of supporting conservation activities. The results showed the ferry-collected samples had traces of DNA from all parts of the vertebrate ecosystem, ranging from small prey fish at the base of the food chain, such as anchovies and sardines,
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Firefighter exposure to wildfire smoke compounds varies, depending on duties
Every summer, wildfires rage across the western U.S., and wildland firefighters are tasked with putting them out. But in the process, they inhale smoke and all the compounds in it, which can be harmful at high amounts. Now, researchers have evaluated the presence of particulate matter and volatile organic compounds (VOCs) around firefighters actively combating blazes, finding the highest exposures
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A recent reversal in the response of western Greenland's ice caps to climate change
Greenland may be best known for its enormous continental scale ice sheet that soars up to 3,000 meters above sea level, whose rapid melting is a leading contributor to global sea level rise. But surrounding this massive ice sheet, which covers 79% of the world's largest island, is Greenland's rugged coastline dotted with ice capped mountainous peaks. These peripheral glaciers and ice caps are now
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Disease genes help developing brains
If the cerebral hemispheres of the forebrain fail to divide properly in an unborn child, this results in holoprosencephaly. A team has discovered candidate genes that can positively influence the severity of this congenital malformation of the forebrain.
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Hand pollination of crops is of major importance
Pollinators — such as bees, butterflies and birds — are essential for agricultural production. However, natural pollination can also fail or be insufficient, which can lead to lower yields and poorer quality. This means alternative solutions are needed. Hand pollination, in which pollen is applied manually or mechanically to the flower, can supplement or replace pollination by animals. Researche
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'Anti-rust' coating for plants protects against disease with cellulose nanofiber
Researchers have found that coating soybean plant leaves with cellulose nanofiber (CNF) gives protection against an aggressive fungal disease. The CNF coating changed leaf surfaces from water repellent to water absorbent, and suppressed pathogen gene expression associated with infection mechanisms, offering resistance to the destructive Asian rust disease. This is the first study to examine CNF ap
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Engineered E. coli could make carbohydrates, renewable fuel, from CO2
Researchers from Newcastle University, UK have engineered Escherichia coli bacteria to capture carbon dioxide (CO2) using hydrogen gas (H2) to convert it into formic acid. The research, published today in Applied and Environmental Microbiology raises the possibility of converting atmospheric CO2 to commodity chemicals.
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The secret to how scorpions, spiders, and ants puncture tough skin
Many small animals grow their teeth, claws and other "tools" out of materials that are filled with zinc, bromine and manganese, reaching up to 20% of the material's weight. My colleagues and I call these "heavy element biomaterials," and in a new paper , we suggest that these materials make it possible for animals to grow scalpel-sharp and precisely shaped tools that are resistant to breaking, de
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What are the ethics of getting a COVID-19 vaccine booster?
After the Biden administration's announcement on COVID-19 booster shots, questions came up about the ethics of vaccinated people in the US getting a booster when so many people around the world are still waiting for their first dose. And while we're pondering ethics, is there a selfish argument for the US to lead efforts to vaccinate people around the world? What about vaccine mandates? And when
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Predator-induced maternal effects determine adaptive antipredator behaviors via egg composition [Evolution]
In high-risk environments with frequent predator encounters, efficient antipredator behavior is key to survival. Parental effects are a powerful mechanism to prepare offspring for coping with such environments, yet clear evidence for adaptive parental effects on offspring antipredator behaviors is missing. Rapid escape reflexes, or "C-start reflexes," are a key…
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Scaffolding mechanism of arrestin-2 in the cRaf/MEK1/ERK signaling cascade [Biophysics and Computational Biology]
Arrestins were initially identified for their role in homologous desensitization and internalization of G protein–coupled receptors. Receptor-bound arrestins also initiate signaling by interacting with other signaling proteins. Arrestins scaffold MAPK signaling cascades, MAPK kinase kinase (MAP3K), MAPK kinase (MAP2K), and MAPK. In particular, arrestins facilitate ERK1/2 activation by scaffolding
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Near-germline human monoclonal antibodies neutralize and protect against multiple arthritogenic alphaviruses [Microbiology]
Arthritogenic alphaviruses are globally distributed, mosquito-transmitted viruses that cause rheumatological disease in humans and include Chikungunya virus (CHIKV), Mayaro virus (MAYV), and others. Although serological evidence suggests that some antibody-mediated heterologous immunity may be afforded by alphavirus infection, the extent to which broadly neutralizing antibodies that protect agains
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Self-mediated positive selection of T cells sets an obstacle to the recognition of nonself [Immunology and Inflammation]
Adaptive immune recognition is mediated by the binding of peptide–human leukocyte antigen complexes by T cells. Positive selection of T cells in the thymus is a fundamental step in the generation of a responding T cell repertoire: only those T cells survive that recognize human peptides presented on the surface…
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CREBA and CREBB in two identified neurons gate long-term memory formation in Drosophila [Neuroscience]
Episodic events are frequently consolidated into labile memory but are not necessarily transferred to persistent long-term memory (LTM). Regulatory mechanisms leading to LTM formation are poorly understood, however, especially at the resolution of identified neurons. Here, we demonstrate enhanced LTM following aversive olfactory conditioning in Drosophila when the transcription factor…
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Increasing and decreasing interregional brain coupling increases and decreases oscillatory activity in the human brain [Psychological and Cognitive Sciences]
The origins of oscillatory activity in the brain are currently debated, but common to many hypotheses is the notion that they reflect interactions between brain areas. Here, we examine this possibility by manipulating the strength of coupling between two human brain regions, ventral premotor cortex (PMv) and primary motor cortex…
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Actin filament debranching regulates cell polarity during cell migration and asymmetric cell division [Cell Biology]
The formation of the branched actin networks is essential for cell polarity, but it remains unclear how the debranching activity of actin filaments contributes to this process. Here, we showed that an evolutionarily conserved coronin family protein, the Caenorhabditis elegans POD-1, debranched the Arp2/3-nucleated actin filaments in vitro. By fluorescence…
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Secure human attachment can promote support for climate change mitigation [Sustainability Science]
Attachment theory is an ethological approach to the development of durable, affective ties between humans. We propose that secure attachment is crucial for understanding climate change mitigation, because the latter is inherently a communal phenomenon resulting from joint action and requiring collective behavioral change. Here, we show that priming attachment…
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Cancer-associated mutations in the p85{alpha} N-terminal SH2 domain activate a spectrum of receptor tyrosine kinases [Cell Biology]
The phosphoinositide 3-kinase regulatory subunit p85α is a key regulator of kinase signaling and is frequently mutated in cancers. In the present study, we showed that in addition to weakening the inhibitory interaction between p85α and p110α, a group of driver mutations in the p85α N-terminal SH2 domain activated EGFR,…
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NMDARs in granule cells contribute to parallel fiber-Purkinȷe cell synaptic plasticity and motor learning [Neuroscience]
Long-term synaptic plasticity is believed to be the cellular substrate of learning and memory. Synaptic plasticity rules are defined by the specific complement of receptors at the synapse and the associated downstream signaling mechanisms. In young rodents, at the cerebellar synapse between granule cells (GC) and Purkinje cells (PC), bidirectional…
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Local thermodynamics govern formation and dissolution of Caenorhabditis elegans P granule condensates [Applied Physical Sciences]
Membraneless compartments, also known as condensates, provide chemically distinct environments and thus spatially organize the cell. A well-studied example of condensates is P granules in the roundworm Caenorhabditis elegans that play an important role in the development of the germline. P granules are RNA-rich protein condensates that share the key…
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Growth-defense trade-offs shape population genetic composition in an iconic forest tree species [Ecology]
All organisms experience fundamental conflicts between divergent metabolic processes. In plants, a pivotal conflict occurs between allocation to growth, which accelerates resource acquisition, and to defense, which protects existing tissue against herbivory. Trade-offs between growth and defense traits are not universally observed, and a central prediction of plant evolutionary ecology…
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IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca2+ through the noncanonical STAT3 pathway [Immunology and Inflammation]
Interleukin 6 (IL-6) is known to regulate the CD4 T cell function by inducing gene expression of a number of cytokines through activation of Stat3 transcription factor. Here, we reveal that IL-6 strengthens the mechanics of CD4 T cells. The presence of IL-6 during activation of mouse and human CD4…
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Optimal ligand discrimination by asymmetric dimerization and turnover of interferon receptors [Biophysics and Computational Biology]
In multicellular organisms, antiviral defense mechanisms evoke a reliable collective immune response despite the noisy nature of biochemical communication between tissue cells. A molecular hub of this response, the interferon I receptor (IFNAR), discriminates between ligand types by their affinity regardless of concentration. To understand how ligand type can be…
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Rational design of ASCT2 inhibitors using an integrated experimental-computational approach [Biophysics and Computational Biology]
ASCT2 (SLC1A5) is a sodium-dependent neutral amino acid transporter that controls amino acid homeostasis in peripheral tissues. In cancer, ASCT2 is up-regulated where it modulates intracellular glutamine levels, fueling cell proliferation. Nutrient deprivation via ASCT2 inhibition provides a potential strategy for cancer therapy. Here, we rationally designed stereospecific inhibitors exploiting…
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The global effectiveness of fact-checking: Evidence from simultaneous experiments in Argentina, Nigeria, South Africa, and the United Kingdom [Social Sciences]
The spread of misinformation is a global phenomenon, with implications for elections, state-sanctioned violence, and health outcomes. Yet, even though scholars have investigated the capacity of fact-checking to reduce belief in misinformation, little evidence exists on the global effectiveness of this approach. We describe fact-checking experiments conducted simultaneously in Argentina,…
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Complement C5 inhibition protects against hemolytic anemia and acute kidney injury in anthrax peptidoglycan-induced sepsis in baboons [Immunology and Inflammation]
Late-stage anthrax infections are characterized by dysregulated immune responses and hematogenous spread of Bacillus anthracis, leading to extreme bacteremia, sepsis, multiple organ failure, and, ultimately, death. Despite the bacterium being nonhemolytic, some fulminant anthrax patients develop a secondary atypical hemolytic uremic syndrome (aHUS) through unknown mechanisms. We recapitulated the
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Diphthamide promotes TOR signaling by increasing the translation of proteins in the TORC1 pathway [Biochemistry]
Diphthamide, a modification found only on translation elongation factor 2 (EF2), was proposed to suppress −1 frameshifting in translation. Although diphthamide is conserved among all eukaryotes, exactly what proteins are affected by diphthamide deletion is not clear in cells. Through genome-wide profiling for a potential −1 frameshifting site, we identified…
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MSX2 safeguards syncytiotrophoblast fate of human trophoblast stem cells [Cell Biology]
Multiple placental pathologies are associated with failures in trophoblast differentiation, yet the underlying transcriptional regulation is poorly understood. Here, we discovered msh homeobox 2 (MSX2) as a key transcriptional regulator of trophoblast identity using the human trophoblast stem cell model. Depletion of MSX2 resulted in activation of the syncytiotrophoblast transcriptional…
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All-or-none disconnection of pyramidal inputs onto parvalbumin-positive interneurons gates ocular dominance plasticity [Neuroscience]
Disinhibition is an obligatory initial step in the remodeling of cortical circuits by sensory experience. Our investigation on disinhibitory mechanisms in the classical model of ocular dominance plasticity uncovered an unexpected form of experience-dependent circuit plasticity. In the layer 2/3 of mouse visual cortex, monocular deprivation triggers a complete, "all-or-none,"…
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Discovery of complex oxides via automated experiments and data science [Chemistry]
The quest to identify materials with tailored properties is increasingly expanding into high-order composition spaces, with a corresponding combinatorial explosion in the number of candidate materials. A key challenge is to discover regions in composition space where materials have novel properties. Traditional predictive models for material properties are not accurate…
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One-dimensional van der Waals heterostructures: Growth mechanism and handedness correlation revealed by nondestructive TEM [Applied Physical Sciences]
We recently synthesized one-dimensional (1D) van der Waals heterostructures in which different atomic layers (e.g., boron nitride or molybdenum disulfide) seamlessly wrap around a single-walled carbon nanotube (SWCNT) and form a coaxial, crystalized heteronanotube. The growth process of 1D heterostructure is unconventional—different crystals need to nucleate on a highly curved…
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Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs [Physiology]
β cells produce, store, and secrete insulin upon elevated blood glucose levels. Insulin secretion is a highly regulated process. The probability for insulin secretory granules to undergo fusion with the plasma membrane or being degraded is correlated with their age. However, the molecular features and stimuli connected to this behavior…
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Pharmacodynamic measures within tumors expose differential activity of PD(L)-1 antibody therapeutics [Medical Sciences]
Macromolecules such as monoclonal antibodies (mAbs) are likely to experience poor tumor penetration because of their large size, and thus low drug exposure of target cells within a tumor could contribute to suboptimal responses. Given the challenge of inadequate quantitative tools to assess mAb activity within tumors, we hypothesized that…
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Regulation of P2X1 receptors by modulators of the cAMP effectors PKA and EPAC [Cell Biology]
P2X1 receptors are adenosine triphosphate (ATP)-gated cation channels that are functionally important for male fertility, bladder contraction, and platelet aggregation. The activity of P2X1 receptors is modulated by lipids and intracellular messengers such as cAMP, which can stimulate protein kinase A (PKA). Exchange protein activated by cAMP (EPAC) is another…
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COVID-19 and mental health of individuals with different personalities [Economic Sciences]
Several studies have been devoted to establishing the effects of the COVID-19 pandemic on mental health across gender, age, and ethnicity. However, much less attention has been paid to the differential effect of COVID-19 according to different personalities. We do this using the UK Household Longitudinal Study (UKHLS), a large-scale…
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Two-step deswelling in the Volume Phase Transition of thermoresponsive microgels [Applied Physical Sciences]
Thermoresponsive microgels are one of the most investigated types of soft colloids, thanks to their ability to undergo a Volume Phase Transition (VPT) close to ambient temperature. However, this fundamental phenomenon still lacks a detailed microscopic understanding, particularly regarding the presence and the role of charges in the deswelling process….
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Monolayer graphene membranes for molecular separation in high-temperature harsh organic solvents [Engineering]
The excellent thermal and chemical stability of monolayer graphene makes it an ideal material for separations at high temperatures and in harsh organic solvents. Here, based on understanding of solvent permeation through nanoporous graphene via molecular dynamics simulation, a resistance model was established to guide the design of a defect-tolerant…
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The 50th anniversary of the Konopka and Benzer 1971 paper in PNAS: "Clock Mutants of Drosophila melanogaster" [Genetics]
On September 1, 1971, unknowingly to most, the world changed for the fields of behavioral genetics and circadian clocks. Ronald Konopka, a graduate student with Seymour Benzer at Caltech, published a paper (1) that I would argue is the most important discovery ultimately leading to our current molecular understanding of…
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