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Nyheder2022september12

House of the Dragon Had One Great Idea
This story contains spoilers for Season 1, Episode 4 of House of the Dragon . Like a court musician ordered to strum a princess's favorite tunes under a Weirwood tree, HBO's House of the Dragon knows how to play all the hits that satisfy Game of Thrones fans. The small-council meetings crackle with passive-aggressive tension. The sets look eye-popping, the dragons only more so. The battle sequenc
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Blood Sugar Sex Magick
"Don't we all want to poke pins into fabric mannequins labelled as our loved ones, or to deface their photographs or whatever? Umm, neither do I." – Smut Clyde
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Street Epistemology
Att ifrågasätta och diskutera djupt troende personers övertygelse med dem är svårt. Om man direkt konfronterar någon med att deras ståndpunkt är felaktig så är den naturliga motreaktionen att gå … Continued Inlägget dök först upp på Vetenskap och Folkbildning .
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Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices
Nature Communications, Published online: 12 September 2022; doi:10.1038/s41467-022-33081-7 Zwitterionic hydrogels are nonfouling and hemocompatibility but several key challenges such as weak mechanical strength and low adhesion hamper their application as coating materials for devices. Here, the authors report a microgel reinforced zwitterionic hydrogel with excellent mechanical robustness and an
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Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis
Nature Communications, Published online: 12 September 2022; doi:10.1038/s41467-022-33006-4 Huang et al. discover a binding site on soluble RANKL that is not found on its membrane-bound homologue. A drug screening identified a small molecule (S3-15) that can target this binding site and has anti-osteoporotic but not immunosuppressive effects.
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SREBP2-dependent lipid gene transcription enhances the infection of human dendritic cells by Zika virus
Nature Communications, Published online: 12 September 2022; doi:10.1038/s41467-022-33041-1 Zika virus (ZIKV) infection suppresses the induction of dendritic cell (DC)-derived immunity, but the underlying mechanistical insights are still lacking. Here the authors show, using in vitro systems profiling of DC transcriptome and epigenome, that ZIKV specifically alters SREBP2-related expression of inf
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Life at high temperature observed in vitro upon laser heating of gold nanoparticles
Nature Communications, Published online: 12 September 2022; doi:10.1038/s41467-022-33074-6 Studying microorganisms at high temperatures is challenging on conventional optical microscopes. Here, the authors introduce the concept of microscale laser heating over the full field of view by using gold nanoparticles as light absorbers, and study thermophile species up to 80 °C.
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Xinjiang lockdown: Chinese censors drown out posts about food and medicine shortages
'Internet commentary personnel' told to deluge social media with thoughts on anything from cooking to their personal mood See all our coronavirus coverage Chinese censors have reportedly been ordered to flood social media with innocuous posts about Xinjiang to drown out mounting complaints of food and medication shortages in a region under lockdown for more than a month. The Ili Kazakh autonomous
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How to Fix Science's Code Problem
Despite increasingly strict journal policies requiring the release of computational code files along with research papers, many scientists remain reluctant to share—underscoring the need for better solutions.
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Massive California fire eases with rains
California firefighters were able to beat back a massive wildfire outside Los Angeles after a tropical storm brought rains and cooler temperatures, US authorities said on Saturday.
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It's Time to Prepare for a Ukrainian Victory
Over the past six days, Ukraine's armed forces have broken through the Russian lines in the northeastern corner of the country, swept eastward, and liberated town after town in what had been occupied territory. First Balakliya, then Kupyansk, then Izium, a city that sits on major supply routes. These names won't mean much to a foreign audience, but they are places that have been beyond reach, imp
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Study: Four major climate tipping points close to triggering
Even if the world somehow manages to limit future warming to the strictest international temperature goal, four Earth-changing climate "tipping points" are still likely to be triggered with a lot more looming as the planet heats more after that, a new study said.
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Concern Grows Around Billionaire Peter Thiel's Period-Tracking App
Peter Thiel — the billionaire venture capitalist, Gawker destroyer and top dollar conservative campaign donor — is now backing a "femtech" app called 28, according to Vice News . The app, created by a controversial women's publication called Evie Magazine , claims to be a "cycle-based" nutrition and wellness program that helps women "reclaim control of [their] bodies, in the most natural way poss
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Guy Sentenced to Prison for Changing People's Cash Into Bitcoin
A US law originally enacted in 1992 was just used to sentence Mark Alexander Hopkins, also known as Doctor Bitcoin and the handle Rizzn, to federal prison. Last week, the crypto enthusiast posted a lengthy Twitter thread about the charges and describing an FBI raid on their home. " I'm going offline for an indeterminate amount of time," Hopkins said online . "I'm headed down to Beaumont FCI, wher
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The Biden Administration Wants to Cut Geothermal Energy Costs by 90 Percent
Heating Up The Biden administration has announced an ambitious new goal to make the use geothermal energy "widespread," underlining the administration's efforts to phase out the country's reliance on fossil fuels. The US Department of Energy (DOE) said in a Thursday statement that US President Joe Biden hopes to make enhanced geothermal systems (EGS) "a widespread renewable energy option" by cutt
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The Disgraced Uber Guy Is Back With a Fun New Plan to Kill Restaurants
Hot Girl Summer is officially over. Make way for… Disgraced Executives Fall? Hot on the heels of Adam Neumann and Martin Shkreli's cursed re-entries into startup world, Travis Kalanick — the former CEO of Uber who resigned from the ride-share app amid a firestorm of privacy concerns, allegations of widespread sexual harassment and gender discrimination within the company, and even the alleged m
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Young People Are Getting Way More Cancer Than Old People Did
You'd expect that cancer rates would be going down. But tough luck — it looks like that's not the case. Instead, early-onset cancer is an increasing threat to the global population, according to a new report published in the journal Nature Reviews Clinical Oncology this week. "Over the past several decades, the incidence of early-onset cancers, often defined as cancers diagnosed in adults less th
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Scientists Are Working on a Gene-Hacking Drug That Could Treat Baldness
Using gene modification techniques, a team of researchers have come up with a new treatment for balding, Wired reports — a condition experienced to varying degrees by two-thirds of American men by age 35 . The team, associated with the University of California, Irvine and a biotech company called Amplifica, believes they've identified the signaling pathway that drive hair growth to find new ways
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T cells that 'nibble' tumors unwittingly help cancer evade the immune response
T cells are capable of killing cancer cells, but tumors have tricks to evade their might. New research details one of these strategies, known as trogocytosis, in which T cells ingest a piece of cancer cell membrane, taking on a bit of cancerous identity. Blocking this process could improve the effectiveness of CAR T cell therapy.
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Where Our Sense of Self Comes From
W e accept as self-evident that each of us is free to think and form our own opinions, that we have autonomous selves. Western societies and institutions are founded on this spirit of individual freedom and self-determination. But it is becoming clear that this very core of Western democratic culture is being undermined—be it by Russia's cyber interference in elections or the widespread dissemina
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Blood test spots multiple cancers without clear symptoms, study finds
Doctors hail new era for cancer screening as major research shows effectiveness of Galleri test Doctors have told health services to prepare for a new era of cancer screening after a study found a simple blood test could spot multiple cancer types in patients before they develop clear symptoms. The Pathfinder study offered the blood test to more than 6,600 adults aged 50 and over, and detected do
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Small Cut Almost Makes Them Tap Out! | Naked and Afraid XL
Stream Naked and Afraid XL on discovery+ ► https://www.discoveryplus.com/show/naked-and-afraid-xl #NakedAndAfraid #Discovery #NakedAndAfraidXL Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitte
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Scientists Use CRISPR to Condense a Million Years of Evolution Into Mere Months
With its inquisitive eyes, furry snout, and lush pelt, the mouse—nicknamed Xiao Zhu, or Little Bamboo—nimbly perched on a bamboo stalk, striking a pretty pose for the camera. But this mouse doesn't exist in nature. Made in a lab in Beijing, Xiao Zhu pushes the boundary of what's possible for genetic engineering and synthetic biology. Rather than harboring the usual 20 pairs of chromosomes, the mo
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What causes bloating?
A bloated and gassy stomach can be uncomfortable — but what causes bloating in the first place? We asked the experts
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Researchers find source of gamma rays in small neighboring galaxy
Through giant lobes of gamma radiation, an international team of researchers have found a small satellite galaxy of the Milky Way filled with dark matter, but whose emissions are more likely the result of millisecond pulsars blasting out cosmic particles, reports a new study in Nature Astronomy.
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If every person in the world isolated for a month, would all transmissible diseases disappear?
The long-running series in which readers answer other readers' questions on subjects ranging from trivial flights of fancy to profound scientific and philosophical concepts If every person in the world isolated from each other for a certain period of time, say a month, would all transmissible diseases disappear? Lily Pauls Post your answers (and new questions) below or send them to nq@theguardian
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There's Nothing Quite Like the Wrath of Losing Your Fantasy League
At first, Damon DuBois's fantasy-football league kept the punishment for the last-place finisher fairly tame. The loser would have to let the champion select their team name for the following year, take care of the housekeeping at the next draft, or, at worst, sport an I suck at fantasy football license plate all off-season. Nothing crazy. But by the final weeks of each season, league members alr
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Mourning rituals help people cope with grief, say scientists
Experts agree on importance of traditions seen after Queen's death in enabling bereaved to process loss The death of Queen Elizabeth II has plunged the royal household and much of the country into a period of mourning, with black armbands and flags at half mast. While such traditions may seem far removed from everyday experiences of bereavement, experts say rituals can help us cope with death. "M
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Cloud labs and remote research aren't the future of science – they're here
At high-end labs in the US and UK, anybody, anywhere, can conduct experiments by remote control cheaply and efficiently. Is the rise of the robot researcher now inevitable? It's 1am on the west coast of America, but the Emerald Cloud Lab , just south of San Francisco, is still busy. Here, more than 100 items of high-end bioscience equipment whirr away on workbenches largely unmanned, 24 hours a d
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After the Queen, What Is Britain?
It wasn't exactly a shock. The ancient and beloved Queen, who had reigned much longer than most of her subjects had lived, was 96 and visibly failing. Leaning on a stick, she managed a smile last week as she invited Liz Truss, Britain's new prime minister, to form a government. And within 48 hours, she was dead. A huge and complex contraption of official mourning, rehearsed to exhaustion over the
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Trump Opened Pandora's Prosecutorial Box
One of Donald Trump's biggest effects on American politics has been bringing ideas that used to be considered fringe into the mainstream. Although the most glaring examples include things like election subversion or cozying up to white supremacists, this summer has seen another previously outré idea become more common: prosecuting a former president. For more than two centuries, law-enforcement a
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Floaters
Magpies fly from branch to branch. In the slow tide of the afternoon, you sleep in my arms; we drift to shore, as sea turtles beach; the ocean surf breaks; an incoming wave foams up on sand then subsides. Stepping into daylight after weeks of smoke, we smell rain before it begins to rain; in the open garage, we exude an aroma of juniper bark, roll a Ping-Pong table into place, and, lowering the l
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The neurocentric worldview – please turn around!
The #neurocentric #worldview – please turn around! 3rd stop: "The #turning #point in the #neurocentric #worldview" In the previous part of the essay "The change in the old, dualistic, reductionist worldviews in the neurosciences" is treated . Now it will be about the practical implementation of the change in the form of structural realism and the resulting turn in the neurocentric worldview. More
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The Move to Eradicate Disagreement
Discovering a point of agreement with a colleague is always alarming. The Atlantic wants more readers rather than fewer, after all, and agreement is poisonous for a subscription base, just as it is for intellectual culture. But here we are: Adam Serwer, in a counterargument to Caitlin Flanagan's essay and my essay after last month's attack on Salman Rushdie, agrees that the attack was ghastly and
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How Masking Changed My Experience of Being Deaf
"I' m sorry for participating in the deaf apocalypse." For a hearing friend and me, this line, delivered in sign language, became a running gag early in the pandemic. She and I had moved in as temporary "corona-roomies" during the spring of 2020. When we left our apartment and pulled our masks over our mouths, she would apologize for having to make communication even harder for me. As we ventured
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Experiencing the perimenopause has many alarming downsides. But it can be sexy, too…
When Christie Watson put on an HRT patch she found herself thinking about sex, all the time. What was going on? I began using HRT patches at 42, after a seemingly catastrophic breakdown that resulted in my climbing into a Sainsbury's fish-finger freezer. My mental health was horrendous. I felt totally outside my own skin, dissociated, and that I'd lost my sense of self. I told a therapist that I
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2022 SkS Weekly Climate Change & Global Warming News Roundup #36
Listing of articles linked to on the Skeptical Science Facebook Page during the past week: Sun, September 4, 2022 through Sat, September 10, 2022. The following articles sparked above average interest during the week (bolded articles are from SkS authors): CNN Exclusive: Scientists make major breakthrough in race to save Caribbean coral , Elon Musk might have it backwards when he talks about the
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Triple ionization and fragmentation of benzene trimers following ultrafast intermolecular Coulombic decay
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-33032-2 Higher-order aromatic clusters are prevalent in biochemical systems, but a full understanding of their structural and dynamical properties is lacking. Here, the authors demonstrate that inner-valence ionization can induce ultrafast relaxation and further fragmentation mechanisms in benzene trimers.
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Identifying and tailoring C–N coupling site for efficient urea synthesis over diatomic Fe–Ni catalyst
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-33066-6 The direct electrocatalytic synthesis of urea via C–N coupling is of great significance. The authors report a diatomic catalyst with bonded Fe–Ni pairs to improve the efficiency of electrochemical urea synthesis from nitrate and CO2.
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Identifying interpretable gene-biomarker associations with functionally informed kernel-based tests in 190,000 exomes
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-32864-2 Genetic association studies for rare variants suffer from lack of power and thus there is a need for methods to improve rare variant discovery. Here, the authors present functionally informed association tests with increased statistical power to aid discovery and interpretation of rare variants.
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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-32811-1 Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering of T cell engaging bispecific protein able to selectively
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Disney+'s Pinocchio Is a Zombie
Robert Zemeckis has always been a director fascinated by avant-garde technology. His biggest films of the '80s and '90s— Who Framed Roger Rabbit , Back to the Future , Forrest Gump —were all revolutionary in their use of visual effects and CGI. In the 2000s, he dove into the nascent field of motion capture to produce the animated movies The Polar Express , Beowulf , and A Christmas Carol . But as
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Record high-Tc and large practical utilization level of electric polarization in metal-free molecular antiferroelectric solid solutions
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-33039-9 Molecular ferroic materials receive considerable interest in view of field-induced switchable polar/magnetic orders. Here, the authors exploit metal-free antiferroelectrics in molecular solid solutions to assemble high-performance ferroic materials.
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Unconventional interfacial water structure of highly concentrated aqueous electrolytes at negative electrode polarizations
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-33129-8 Water-in-salt electrolytes can be useful for future electrochemical energy storage systems. Here, the authors investigate the potential-dependent double-layer structures at the interface between a gold electrode and a highly concentrated aqueous electrolyte solution via in situ Raman measurements.
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Wilkes subglacial basin ice sheet response to Southern Ocean warming during late Pleistocene interglacials
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-32847-3 Crotti et al. reconstructed the dynamics of the Wilkes Subglacial Basin (Antarctica) during the past 350,000 years. Their study reveals that a portion of the East Antarctic ice sheet experienced an extensive retreat 330,000 years ago.
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Hit All the Right Notes with the Best Keyboards for Beginners in 2022
Whether you're an adult looking to pick up some jazz chops, or you're shopping for a great keyboard for your child's practice sessions, keyboards for beginners offer remarkable tool sets for learning piano. Most keyboards come with multiple voices that will let you flip from baby grand to harpsichord, as well as midi connections that can sync your keys with your digital audio workstation if you'r
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Hundreds of Thousands of American Homes Will Be Swallowed by the Sea, Scientists Say
New Atlantis Owners of coveted coastal properties , beware. According to a new analysis published this week by the research nonprofit Climate Central, roughly 4.4 million acres of land and 650,000 individual properties will be below sea level by the year 2050, based on current emission levels. Needless to say, that's a staggering amount of lost land and money — a shocking illustration of the deva
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Study Finds LSD Therapy Strikingly Effective at Reducing Anxiety and Depression
According to new research, psychedelic-assisted therapy could be a surprisingly effective and long-lasting treatment for anxiety and depression-related symptoms. As detailed in a new study published in the journal Biological Psychiatry , a team of Swiss researchers administered 20 participants, who were diagnosed with a life-threatening illness, and a further 22 participants with a mental disorde
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Vice President Shows Up Late, Gets Cut Off From Astronauts Mid-Call
Cut Off Vice President Kamala Harris' call with astronauts on the International Space Station was cut short earlier today when the ISS passed out of communication range. Unfortunately, that snafu appears to be self-inflicted — the veep was apparently late for the appointment. And space waits for no one. "ISS passed out of range in the middle of the discussion," Space Policy Online editor Marcia S
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Sorry, But Biden's New Monkeypox Doctor Seems Absolutely Awesome
The doctor helping spearhead President Joe Biden's monkeypox response is an openly gay man who's posed for many a thirst trap in tasteful leather — and sorry, but that means he's an absolutely perfect choice for the job. In early August, the White House appointed top FEMA official Robert Fenton as the National Monkeypox Response Coordinator. But it was his deputy appointee, Dr. Demetre Daskalakis
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Battle-Scarred Ukraine Nuclear Plant Cooling Systems Hanging by a Thread, Officials Say
Not Good Put bluntly, the situation at Ukraine's Zaporizhzhia nuclear power plant is bad. Really bad. The New York Times reports that shelling around the Russia-controlled plant has destroyed the power infrastructure fueling the surrounding town of Enerhodar, where the facility's dogged workers reside — leading to widespread blackouts, no running water or sewage, and, dangerously, no offsite powe
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NASA's Webb catches Tarantula Nebula
A stellar nursery nicknamed the Tarantula Nebula has been captured in crisp detail by NASA's Webb telescope, revealing hitherto unseen features that deepen scientific understanding, the agency said Tuesday.
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I Wish My Friend Could Have Read Her Own Obituary
I wish my friend Anne Garrels could have lived just a few days longer. She died early last Wednesday, but if she'd held on a few more hours, I like to imagine that she would have been able to enjoy (even while pretending to dismiss) the torrent of admiration from colleagues and listeners for her work as a foreign correspondent with National Public Radio. I wish she'd been able to read the glowing
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The Angels of Lviv
Photographs by Elena Subach As soon as the first air-raid sirens sounded last winter, Elena Subach, a photographer and curator in Lviv, began to worry. "Lviv is itself an open-air museum," she told me. "You cannot hide it in a bomb shelter." All over Ukraine, curators mobilized to try to protect what they could and transfer movable items for safekeeping. In Lviv, museum staff and volunteers rushe
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Parker is Torn on Buying this Gold Producing Plant | Gold Rush: Parker's Trail
Stream Gold Rush: Parker's Trail on discovery+ ▶︎ https://www.discoveryplus.com/show/gold-rush-parkers-trail #GoldRush #discovery #ParkersTrail Subscribe to Discovery: http://bit.ly/SubscribeDiscovery Follow Us on TikTok: https://www.tiktok.com/@Discovery We're on Instagram! https://instagram.com/Discovery Join Us on Facebook: https://www.facebook.com/Discovery Follow Us on Twitter: https://twitt
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Weekend reads: Fake reproductive health data alleged; 'bad brains;' 'heinous' misconduct
Would you consider a donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured: Physics publisher retracting nearly 500 likely paper mill papers Exclusive: NIH researcher resigned amid retractions, including Nature paper Didier Raoult papers earn expressions of concern as criminal investigation gets underway Brain tumor researchers retract pape
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Små jordgubbar när bekämpningsmedel gör bin slöa
Vilda bin som får i sig växtskyddsmedlet klotianidin från behandlad raps blir långsammare. De tar längre tid på sig att pollinera jordgubbsblommor och bären blir mindre, visar en studie från Lunds universitet. Inlägget dök först upp på forskning.se .
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Cancer breakthrough is a 'wake-up' call on danger of air pollution
Scientists uncover link between car fumes and lung cancer that helps explain why so many non-smokers develop disease Scientists have uncovered how air pollution causes lung cancer in groundbreaking research that promises to rewrite our understanding of the disease. The findings outline how fine particulates contained in car fumes "awaken" dormant mutations in lung cells and tip them into a cancer
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The Right's Brittney Griner Obsession
Brittney Griner is still detained in Russia. The WNBA star has now been imprisoned for 205 long days. In August, Griner was found guilty of drug possession and smuggling for traveling with less than a gram of cannabis oil, and sentenced to nine years in a Russian penal colony. During her trial, lawyers argued that she had a medical note for the cannabis oil, but it did no good. Ironically, this i
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Why go back to the Moon?
On September 12, 1962, then US president John F Kennedy informed the public of his plan to put a man on the Moon by the end of the decade.
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Artificial ocean cooling to weaken hurricanes is futile, study finds
A new study found that even if we did have the infinite power to artificially cool enough of the oceans to weaken a hurricane, the benefits would be minimal. The study led by scientists at the University of Miami (UM) Rosenstiel School of Marine, Atmospheric and Earth Science showed that the energy alone that is needed to use intervention technology to weaken a hurricane before landfall makes it a
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New study on financial management in higher ed shows that budgeting flexibility is the key to security
The decades-long decline in U.S. college enrollment experienced its largest two-year decrease in more than 50 years this spring. Universities increasingly face stiffer competition with less money from state budgets, which does not bode well for their financial security. A new study from the Strategic Management Journal (SMJ) finds that the universities thriving in this environment are doing more w
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Purpose beyond profit: How brands can benefit consumer well-being
Researchers from The Wharton School of the University of Pennsylvania and the Owen Graduate School of Management at Vanderbilt University have published a new paper in the Journal of Consumer Psychology that offers fresh insights into "brand purpose" and its potential benefits to consumers.
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7 fun facts about sweat
Perspiration can be a stinky nuisance as temperatures climb, but scientists say we shouldn't sell sweat short. There's so much more to the briny stuff than meets the eye. (Image credit: Werayuth Tessrimuang/EyeEm/Getty Images)
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1934: Nimbus genoptager produktionen af motorcykler
Den nyopførte motorcyklefabrik på Peter Bangsvej er udstyret med de mest moderne specialmaskiner og kan producere 1.000 maskiner om året. Den nye konstruktion er topventilet med et kompressionsforhold på 1:5 og kan udvikle ca. 18 HK.
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September full moon 2022: how to take a good photograph of the harvest moon tonight on your phone or camera
Guardian Australia picture editor Carly Earl explains the dos and don'ts of photographing the moon Get our free news app , morning email briefing or daily news podcast With the September 2022 full moon rising, also known as the harvest moon, many people will pull out their mobile phones to try and get an Instagram-worthy photograph, but unfortunately the moon is really challenging to get a great
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Intelligent toaster and a 'nappy fullness sensor' among UK inventions in 2021
Other inventions include a humane insect remover, a gas-flushing toilet and a collar that stops dogs fighting An artificial intelligence-driven toaster that gets the perfect level of brownness each time, a device to humanely remove flying insects from a room, and a sensor that tells you when a nappy needs changing. These were just three of the new things created by UK based inventors last year. A
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The primeval optical evolving matter by optical binding inside and outside the photon beam
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-33070-w Optical binding enables light-induced assembly of many particles within a focus area. Here, the authors demonstrate that optical binding can occur outside the irradiated area by scattered light interacting with the particles outside the focus, generating arc-shape potential wells for particle trapping.
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Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-33063-9 Myofibroblasts contribute to the development of liver fibrosis. Here, the authors report that the transcription factor Basonuclin 2 (BNC2) integrates fibrogenic signals and drives myofibroblastic transcriptional activation in liver fibrosis.
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Genome-scale RNA interference profiling of Trypanosoma brucei cell cycle progression defects
Nature Communications, Published online: 10 September 2022; doi:10.1038/s41467-022-33109-y Progression of the canonical eukaryotic cell cycle is tightly regulated. While the cell cycle control of flagellated protozoa Trypanosoma brucei shares conserved features with other eukaryotes certain cell cycle checkpoints are absent. Here, Marques et al. provide a genome-scale RNAi screen followed by sort
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Så fungerar unika jätteteleskopet James Webb
På juldagen 2021 sköts superteleskopet James Webb ut i rymden. Inuti rymdraketen fanns en hopvikt spegel på 6,5 meter i diameter och en solsköld som båda skulle vikas ut i rymden. I en ny dokumentär berättar forskarna om de nagelbitande dagarna när teleskopet skjutits i väg. – Det som är utmanande är att det aldrig har gjorts förut, säger Carl Starr som var ansvarig för att teleskopet skulle fälla
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Se hur galaxkrocken tänder stjärnor
Nu strömmar de första bilderna från det nya James Webb-teleskopet in och astronomer fascineras över detaljrikedomen i dem. En av bilderna föreställer Stephans kvintett, en grupp avlägsna galaxer som har fångats i en våldsam dans runt varandra. – Första gången jag såg den här bilden tyckte jag den såg organisk ut, som om en navelsträng rörde sig mellan de här galaxerna, säger professorn Susanne Aal
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Food insecurity has lasting impacts on the brains and behavior of mice
The pandemic saw an increase in the number of food-insecure households with children in America, but what are the consequences? A new study, conducted in mice, is among the first to look at impacts on the brain and behavior of food insecurity apart from other adversities in the environment. Mice raised with uncertain food resources exhibited changes in adulthood in the brain's dopamine network and
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Why the Russian Military Brutalizes Ukraine
This is an edition of The Atlantic Daily, a newsletter that guides you through the biggest stories of the day, helps you discover new ideas, and recommends the best in culture. Sign up for it here . War is always a brutal business, but why is the Russian military so determined to inflict civilian casualties on neighboring Ukraine? I talked with a fellow Russia expert. But first, here are three ne
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Surprising discovery shows a slowing of continental plate movement controlled the timing of Earth's largest volcanic events
Scientists have shed new light on the timing and likely cause of major volcanic events that occurred millions of years ago and caused such climatic and biological upheaval that they drove some of the most devastating extinction events in Earth's history. Surprisingly the new research suggests a slowing of continental plate movement was the critical event that enabled magma to rise to the Earth's s
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The roots of biodiversity: How proteins differ across species
In a new study, Yale researchers have compared the proteomes of skin cells from 11 mammals, which, they say, will help scientists understand the molecular drivers of biodiversity and how these factors have evolved over time. They found that while many proteins are similarly variable both across and within species, some are more variable between species, providing clues about which proteins might b
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